---
_id: '7744'
article_processing_charge: No
article_type: original
author:
- first_name: Matthew Richard
  full_name: Robinson, Matthew Richard
  id: E5D42276-F5DA-11E9-8E24-6303E6697425
  last_name: Robinson
  orcid: 0000-0001-8982-8813
- first_name: Naomi R.
  full_name: Wray, Naomi R.
  last_name: Wray
- first_name: Peter M.
  full_name: Visscher, Peter M.
  last_name: Visscher
citation:
  ama: Robinson MR, Wray NR, Visscher PM. Explaining additional genetic variation
    in complex traits. <i>Trends in Genetics</i>. 2014;30(4):124-132. doi:<a href="https://doi.org/10.1016/j.tig.2014.02.003">10.1016/j.tig.2014.02.003</a>
  apa: Robinson, M. R., Wray, N. R., &#38; Visscher, P. M. (2014). Explaining additional
    genetic variation in complex traits. <i>Trends in Genetics</i>. Elsevier. <a href="https://doi.org/10.1016/j.tig.2014.02.003">https://doi.org/10.1016/j.tig.2014.02.003</a>
  chicago: Robinson, Matthew Richard, Naomi R. Wray, and Peter M. Visscher. “Explaining
    Additional Genetic Variation in Complex Traits.” <i>Trends in Genetics</i>. Elsevier,
    2014. <a href="https://doi.org/10.1016/j.tig.2014.02.003">https://doi.org/10.1016/j.tig.2014.02.003</a>.
  ieee: M. R. Robinson, N. R. Wray, and P. M. Visscher, “Explaining additional genetic
    variation in complex traits,” <i>Trends in Genetics</i>, vol. 30, no. 4. Elsevier,
    pp. 124–132, 2014.
  ista: Robinson MR, Wray NR, Visscher PM. 2014. Explaining additional genetic variation
    in complex traits. Trends in Genetics. 30(4), 124–132.
  mla: Robinson, Matthew Richard, et al. “Explaining Additional Genetic Variation
    in Complex Traits.” <i>Trends in Genetics</i>, vol. 30, no. 4, Elsevier, 2014,
    pp. 124–32, doi:<a href="https://doi.org/10.1016/j.tig.2014.02.003">10.1016/j.tig.2014.02.003</a>.
  short: M.R. Robinson, N.R. Wray, P.M. Visscher, Trends in Genetics 30 (2014) 124–132.
date_created: 2020-04-30T10:58:58Z
date_published: 2014-04-01T00:00:00Z
date_updated: 2021-01-12T08:15:14Z
day: '01'
doi: 10.1016/j.tig.2014.02.003
extern: '1'
intvolume: '        30'
issue: '4'
language:
- iso: eng
month: '04'
oa_version: None
page: 124-132
publication: Trends in Genetics
publication_identifier:
  issn:
  - 0168-9525
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Explaining additional genetic variation in complex traits
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 30
year: '2014'
...
---
_id: '6135'
abstract:
- lang: eng
  text: Many organisms have stress response pathways, components of which share homology
    with players in complex human disease pathways. Research on stress response in
    the nematode worm Caenorhabditis elegans has provided detailed insights into the
    genetic and molecular mechanisms underlying complex human diseases. In this review
    we focus on four different types of environmental stress responses – heat shock,
    oxidative stress, hypoxia, and osmotic stress – and on how these can be used to
    study the genetics of complex human diseases. All four types of responses involve
    the genetic machineries that underlie a number of complex human diseases such
    as cancer and neurodegenerative diseases, including Alzheimer's and Parkinson's.
    We highlight the types of stress response experiments required to detect the genes
    and pathways underlying human disease and suggest that studying stress biology
    in worms can be translated to understanding human disease and provide potential
    targets for drug discovery.
author:
- first_name: Miriam
  full_name: Rodriguez, Miriam
  last_name: Rodriguez
- first_name: L. Basten
  full_name: Snoek, L. Basten
  last_name: Snoek
- first_name: Mario
  full_name: de Bono, Mario
  id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
  last_name: de Bono
  orcid: 0000-0001-8347-0443
- first_name: Jan E.
  full_name: Kammenga, Jan E.
  last_name: Kammenga
citation:
  ama: 'Rodriguez M, Snoek LB, de Bono M, Kammenga JE. Worms under stress: C. elegans
    stress response and its relevance to complex human disease and aging. <i>Trends
    in Genetics</i>. 2013;29(6):367-374. doi:<a href="https://doi.org/10.1016/j.tig.2013.01.010">10.1016/j.tig.2013.01.010</a>'
  apa: 'Rodriguez, M., Snoek, L. B., de Bono, M., &#38; Kammenga, J. E. (2013). Worms
    under stress: C. elegans stress response and its relevance to complex human disease
    and aging. <i>Trends in Genetics</i>. Elsevier. <a href="https://doi.org/10.1016/j.tig.2013.01.010">https://doi.org/10.1016/j.tig.2013.01.010</a>'
  chicago: 'Rodriguez, Miriam, L. Basten Snoek, Mario de Bono, and Jan E. Kammenga.
    “Worms under Stress: C. Elegans Stress Response and Its Relevance to Complex Human
    Disease and Aging.” <i>Trends in Genetics</i>. Elsevier, 2013. <a href="https://doi.org/10.1016/j.tig.2013.01.010">https://doi.org/10.1016/j.tig.2013.01.010</a>.'
  ieee: 'M. Rodriguez, L. B. Snoek, M. de Bono, and J. E. Kammenga, “Worms under stress:
    C. elegans stress response and its relevance to complex human disease and aging,”
    <i>Trends in Genetics</i>, vol. 29, no. 6. Elsevier, pp. 367–374, 2013.'
  ista: 'Rodriguez M, Snoek LB, de Bono M, Kammenga JE. 2013. Worms under stress:
    C. elegans stress response and its relevance to complex human disease and aging.
    Trends in Genetics. 29(6), 367–374.'
  mla: 'Rodriguez, Miriam, et al. “Worms under Stress: C. Elegans Stress Response
    and Its Relevance to Complex Human Disease and Aging.” <i>Trends in Genetics</i>,
    vol. 29, no. 6, Elsevier, 2013, pp. 367–74, doi:<a href="https://doi.org/10.1016/j.tig.2013.01.010">10.1016/j.tig.2013.01.010</a>.'
  short: M. Rodriguez, L.B. Snoek, M. de Bono, J.E. Kammenga, Trends in Genetics 29
    (2013) 367–374.
date_created: 2019-03-20T14:17:42Z
date_published: 2013-06-01T00:00:00Z
date_updated: 2021-01-12T08:06:17Z
day: '01'
doi: 10.1016/j.tig.2013.01.010
extern: '1'
intvolume: '        29'
issue: '6'
language:
- iso: eng
month: '06'
oa_version: None
page: 367-374
publication: Trends in Genetics
publication_identifier:
  issn:
  - 0168-9525
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: 'Worms under stress: C. elegans stress response and its relevance to complex
  human disease and aging'
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 29
year: '2013'
...
---
_id: '6148'
author:
- first_name: Jan E.
  full_name: Kammenga, Jan E.
  last_name: Kammenga
- first_name: Patrick C.
  full_name: Phillips, Patrick C.
  last_name: Phillips
- first_name: Mario
  full_name: de Bono, Mario
  id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
  last_name: de Bono
  orcid: 0000-0001-8347-0443
- first_name: Agnieszka
  full_name: Doroszuk, Agnieszka
  last_name: Doroszuk
citation:
  ama: 'Kammenga JE, Phillips PC, de Bono M, Doroszuk A. Beyond induced mutants: using
    worms to study natural variation in genetic pathways. <i>Trends in Genetics</i>.
    2008;24(4):178-185. doi:<a href="https://doi.org/10.1016/j.tig.2008.01.001">10.1016/j.tig.2008.01.001</a>'
  apa: 'Kammenga, J. E., Phillips, P. C., de Bono, M., &#38; Doroszuk, A. (2008).
    Beyond induced mutants: using worms to study natural variation in genetic pathways.
    <i>Trends in Genetics</i>. Elsevier. <a href="https://doi.org/10.1016/j.tig.2008.01.001">https://doi.org/10.1016/j.tig.2008.01.001</a>'
  chicago: 'Kammenga, Jan E., Patrick C. Phillips, Mario de Bono, and Agnieszka Doroszuk.
    “Beyond Induced Mutants: Using Worms to Study Natural Variation in Genetic Pathways.”
    <i>Trends in Genetics</i>. Elsevier, 2008. <a href="https://doi.org/10.1016/j.tig.2008.01.001">https://doi.org/10.1016/j.tig.2008.01.001</a>.'
  ieee: 'J. E. Kammenga, P. C. Phillips, M. de Bono, and A. Doroszuk, “Beyond induced
    mutants: using worms to study natural variation in genetic pathways,” <i>Trends
    in Genetics</i>, vol. 24, no. 4. Elsevier, pp. 178–185, 2008.'
  ista: 'Kammenga JE, Phillips PC, de Bono M, Doroszuk A. 2008. Beyond induced mutants:
    using worms to study natural variation in genetic pathways. Trends in Genetics.
    24(4), 178–185.'
  mla: 'Kammenga, Jan E., et al. “Beyond Induced Mutants: Using Worms to Study Natural
    Variation in Genetic Pathways.” <i>Trends in Genetics</i>, vol. 24, no. 4, Elsevier,
    2008, pp. 178–85, doi:<a href="https://doi.org/10.1016/j.tig.2008.01.001">10.1016/j.tig.2008.01.001</a>.'
  short: J.E. Kammenga, P.C. Phillips, M. de Bono, A. Doroszuk, Trends in Genetics
    24 (2008) 178–185.
date_created: 2019-03-21T08:19:45Z
date_published: 2008-04-01T00:00:00Z
date_updated: 2021-01-12T08:06:21Z
day: '01'
doi: 10.1016/j.tig.2008.01.001
extern: '1'
external_id:
  pmid:
  - '18325626'
intvolume: '        24'
issue: '4'
language:
- iso: eng
month: '04'
oa_version: None
page: 178-185
pmid: 1
publication: Trends in Genetics
publication_identifier:
  issn:
  - 0168-9525
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: 'Beyond induced mutants: using worms to study natural variation in genetic
  pathways'
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 24
year: '2008'
...
---
_id: '12201'
abstract:
- lang: eng
  text: The development of plant lateral organs is interesting because, although many
    of the same genes seem to be involved in the early growth of primordia, completely
    different gene combinations are required for the complete development of organs
    such as leaves and stamens. Thus, the genes common to the development of most
    organs, which generally form and polarize the primordial ‘envelope’, must at some
    stage interact with those that ‘install’ the functional content of the organ –
    in the case of the stamen, the four microsporangia. Although distinct genetic
    pathways of organ initiation, polarity establishment and setting up the reproductive
    cell line can readily be recognized, they do not occur sequentially. Rather, they
    are activated early and run in parallel. There is evidence for continuing crosstalk
    between these pathways.
acknowledgement: X.F. holds a Clarendon Scholarship from the University of Oxford.
  We thank Angela Hay and Jill Harrison for helpful advice and discussion.
article_processing_charge: No
article_type: original
author:
- first_name: Xiaoqi
  full_name: Feng, Xiaoqi
  id: e0164712-22ee-11ed-b12a-d80fcdf35958
  last_name: Feng
  orcid: 0000-0002-4008-1234
- first_name: Hugh G.
  full_name: Dickinson, Hugh G.
  last_name: Dickinson
citation:
  ama: Feng X, Dickinson HG. Packaging the male germline in plants. <i>Trends in Genetics</i>.
    2007;23(10):503-510. doi:<a href="https://doi.org/10.1016/j.tig.2007.08.005">10.1016/j.tig.2007.08.005</a>
  apa: Feng, X., &#38; Dickinson, H. G. (2007). Packaging the male germline in plants.
    <i>Trends in Genetics</i>. Elsevier BV. <a href="https://doi.org/10.1016/j.tig.2007.08.005">https://doi.org/10.1016/j.tig.2007.08.005</a>
  chicago: Feng, Xiaoqi, and Hugh G. Dickinson. “Packaging the Male Germline in Plants.”
    <i>Trends in Genetics</i>. Elsevier BV, 2007. <a href="https://doi.org/10.1016/j.tig.2007.08.005">https://doi.org/10.1016/j.tig.2007.08.005</a>.
  ieee: X. Feng and H. G. Dickinson, “Packaging the male germline in plants,” <i>Trends
    in Genetics</i>, vol. 23, no. 10. Elsevier BV, pp. 503–510, 2007.
  ista: Feng X, Dickinson HG. 2007. Packaging the male germline in plants. Trends
    in Genetics. 23(10), 503–510.
  mla: Feng, Xiaoqi, and Hugh G. Dickinson. “Packaging the Male Germline in Plants.”
    <i>Trends in Genetics</i>, vol. 23, no. 10, Elsevier BV, 2007, pp. 503–10, doi:<a
    href="https://doi.org/10.1016/j.tig.2007.08.005">10.1016/j.tig.2007.08.005</a>.
  short: X. Feng, H.G. Dickinson, Trends in Genetics 23 (2007) 503–510.
date_created: 2023-01-16T09:22:44Z
date_published: 2007-10-01T00:00:00Z
date_updated: 2023-05-08T10:58:47Z
department:
- _id: XiFe
doi: 10.1016/j.tig.2007.08.005
extern: '1'
external_id:
  pmid:
  - '17825943'
intvolume: '        23'
issue: '10'
keyword:
- Genetics
language:
- iso: eng
month: '10'
oa_version: None
page: 503-510
pmid: 1
publication: Trends in Genetics
publication_identifier:
  issn:
  - 0168-9525
publication_status: published
publisher: Elsevier BV
quality_controlled: '1'
scopus_import: '1'
status: public
title: Packaging the male germline in plants
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 23
year: '2007'
...