[{"citation":{"chicago":"Robinson, Matthew Richard, Naomi R. Wray, and Peter M. Visscher. “Explaining Additional Genetic Variation in Complex Traits.” <i>Trends in Genetics</i>. Elsevier, 2014. <a href=\"https://doi.org/10.1016/j.tig.2014.02.003\">https://doi.org/10.1016/j.tig.2014.02.003</a>.","ieee":"M. R. Robinson, N. R. Wray, and P. M. Visscher, “Explaining additional genetic variation in complex traits,” <i>Trends in Genetics</i>, vol. 30, no. 4. Elsevier, pp. 124–132, 2014.","ista":"Robinson MR, Wray NR, Visscher PM. 2014. Explaining additional genetic variation in complex traits. Trends in Genetics. 30(4), 124–132.","mla":"Robinson, Matthew Richard, et al. “Explaining Additional Genetic Variation in Complex Traits.” <i>Trends in Genetics</i>, vol. 30, no. 4, Elsevier, 2014, pp. 124–32, doi:<a href=\"https://doi.org/10.1016/j.tig.2014.02.003\">10.1016/j.tig.2014.02.003</a>.","short":"M.R. Robinson, N.R. Wray, P.M. Visscher, Trends in Genetics 30 (2014) 124–132.","ama":"Robinson MR, Wray NR, Visscher PM. Explaining additional genetic variation in complex traits. <i>Trends in Genetics</i>. 2014;30(4):124-132. doi:<a href=\"https://doi.org/10.1016/j.tig.2014.02.003\">10.1016/j.tig.2014.02.003</a>","apa":"Robinson, M. R., Wray, N. R., &#38; Visscher, P. M. (2014). Explaining additional genetic variation in complex traits. <i>Trends in Genetics</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.tig.2014.02.003\">https://doi.org/10.1016/j.tig.2014.02.003</a>"},"title":"Explaining additional genetic variation in complex traits","day":"01","article_type":"original","year":"2014","oa_version":"None","author":[{"orcid":"0000-0001-8982-8813","id":"E5D42276-F5DA-11E9-8E24-6303E6697425","full_name":"Robinson, Matthew Richard","first_name":"Matthew Richard","last_name":"Robinson"},{"last_name":"Wray","full_name":"Wray, Naomi R.","first_name":"Naomi R."},{"last_name":"Visscher","full_name":"Visscher, Peter M.","first_name":"Peter M."}],"type":"journal_article","date_updated":"2021-01-12T08:15:14Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","language":[{"iso":"eng"}],"doi":"10.1016/j.tig.2014.02.003","publication_identifier":{"issn":["0168-9525"]},"page":"124-132","issue":"4","article_processing_charge":"No","extern":"1","month":"04","_id":"7744","date_created":"2020-04-30T10:58:58Z","date_published":"2014-04-01T00:00:00Z","publisher":"Elsevier","publication_status":"published","quality_controlled":"1","publication":"Trends in Genetics","volume":30,"status":"public","intvolume":"        30"},{"publication_status":"published","publisher":"Elsevier","quality_controlled":"1","publication":"Trends in Genetics","volume":29,"status":"public","intvolume":"        29","page":"367-374","issue":"6","extern":"1","month":"06","date_created":"2019-03-20T14:17:42Z","_id":"6135","abstract":[{"text":"Many organisms have stress response pathways, components of which share homology with players in complex human disease pathways. Research on stress response in the nematode worm Caenorhabditis elegans has provided detailed insights into the genetic and molecular mechanisms underlying complex human diseases. In this review we focus on four different types of environmental stress responses – heat shock, oxidative stress, hypoxia, and osmotic stress – and on how these can be used to study the genetics of complex human diseases. All four types of responses involve the genetic machineries that underlie a number of complex human diseases such as cancer and neurodegenerative diseases, including Alzheimer's and Parkinson's. We highlight the types of stress response experiments required to detect the genes and pathways underlying human disease and suggest that studying stress biology in worms can be translated to understanding human disease and provide potential targets for drug discovery.","lang":"eng"}],"date_published":"2013-06-01T00:00:00Z","date_updated":"2021-01-12T08:06:17Z","language":[{"iso":"eng"}],"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","doi":"10.1016/j.tig.2013.01.010","publication_identifier":{"issn":["0168-9525"]},"citation":{"short":"M. Rodriguez, L.B. Snoek, M. de Bono, J.E. Kammenga, Trends in Genetics 29 (2013) 367–374.","apa":"Rodriguez, M., Snoek, L. B., de Bono, M., &#38; Kammenga, J. E. (2013). Worms under stress: C. elegans stress response and its relevance to complex human disease and aging. <i>Trends in Genetics</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.tig.2013.01.010\">https://doi.org/10.1016/j.tig.2013.01.010</a>","ama":"Rodriguez M, Snoek LB, de Bono M, Kammenga JE. Worms under stress: C. elegans stress response and its relevance to complex human disease and aging. <i>Trends in Genetics</i>. 2013;29(6):367-374. doi:<a href=\"https://doi.org/10.1016/j.tig.2013.01.010\">10.1016/j.tig.2013.01.010</a>","ista":"Rodriguez M, Snoek LB, de Bono M, Kammenga JE. 2013. Worms under stress: C. elegans stress response and its relevance to complex human disease and aging. Trends in Genetics. 29(6), 367–374.","ieee":"M. Rodriguez, L. B. Snoek, M. de Bono, and J. E. Kammenga, “Worms under stress: C. elegans stress response and its relevance to complex human disease and aging,” <i>Trends in Genetics</i>, vol. 29, no. 6. Elsevier, pp. 367–374, 2013.","chicago":"Rodriguez, Miriam, L. Basten Snoek, Mario de Bono, and Jan E. Kammenga. “Worms under Stress: C. Elegans Stress Response and Its Relevance to Complex Human Disease and Aging.” <i>Trends in Genetics</i>. Elsevier, 2013. <a href=\"https://doi.org/10.1016/j.tig.2013.01.010\">https://doi.org/10.1016/j.tig.2013.01.010</a>.","mla":"Rodriguez, Miriam, et al. “Worms under Stress: C. Elegans Stress Response and Its Relevance to Complex Human Disease and Aging.” <i>Trends in Genetics</i>, vol. 29, no. 6, Elsevier, 2013, pp. 367–74, doi:<a href=\"https://doi.org/10.1016/j.tig.2013.01.010\">10.1016/j.tig.2013.01.010</a>."},"title":"Worms under stress: C. elegans stress response and its relevance to complex human disease and aging","day":"01","oa_version":"None","year":"2013","type":"journal_article","author":[{"last_name":"Rodriguez","first_name":"Miriam","full_name":"Rodriguez, Miriam"},{"last_name":"Snoek","first_name":"L. Basten","full_name":"Snoek, L. Basten"},{"id":"4E3FF80E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8347-0443","first_name":"Mario","full_name":"de Bono, Mario","last_name":"de Bono"},{"full_name":"Kammenga, Jan E.","first_name":"Jan E.","last_name":"Kammenga"}]},{"publication":"Trends in Genetics","quality_controlled":"1","intvolume":"        24","status":"public","volume":24,"publication_status":"published","publisher":"Elsevier","month":"04","extern":"1","date_created":"2019-03-21T08:19:45Z","_id":"6148","date_published":"2008-04-01T00:00:00Z","page":"178-185","issue":"4","external_id":{"pmid":["18325626"]},"language":[{"iso":"eng"}],"date_updated":"2021-01-12T08:06:21Z","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"issn":["0168-9525"]},"doi":"10.1016/j.tig.2008.01.001","pmid":1,"day":"01","type":"journal_article","author":[{"first_name":"Jan E.","full_name":"Kammenga, Jan E.","last_name":"Kammenga"},{"last_name":"Phillips","full_name":"Phillips, Patrick C.","first_name":"Patrick C."},{"first_name":"Mario","full_name":"de Bono, Mario","last_name":"de Bono","id":"4E3FF80E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8347-0443"},{"first_name":"Agnieszka","full_name":"Doroszuk, Agnieszka","last_name":"Doroszuk"}],"oa_version":"None","year":"2008","citation":{"short":"J.E. Kammenga, P.C. Phillips, M. de Bono, A. Doroszuk, Trends in Genetics 24 (2008) 178–185.","ama":"Kammenga JE, Phillips PC, de Bono M, Doroszuk A. Beyond induced mutants: using worms to study natural variation in genetic pathways. <i>Trends in Genetics</i>. 2008;24(4):178-185. doi:<a href=\"https://doi.org/10.1016/j.tig.2008.01.001\">10.1016/j.tig.2008.01.001</a>","apa":"Kammenga, J. E., Phillips, P. C., de Bono, M., &#38; Doroszuk, A. (2008). Beyond induced mutants: using worms to study natural variation in genetic pathways. <i>Trends in Genetics</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.tig.2008.01.001\">https://doi.org/10.1016/j.tig.2008.01.001</a>","chicago":"Kammenga, Jan E., Patrick C. Phillips, Mario de Bono, and Agnieszka Doroszuk. “Beyond Induced Mutants: Using Worms to Study Natural Variation in Genetic Pathways.” <i>Trends in Genetics</i>. Elsevier, 2008. <a href=\"https://doi.org/10.1016/j.tig.2008.01.001\">https://doi.org/10.1016/j.tig.2008.01.001</a>.","ieee":"J. E. Kammenga, P. C. Phillips, M. de Bono, and A. Doroszuk, “Beyond induced mutants: using worms to study natural variation in genetic pathways,” <i>Trends in Genetics</i>, vol. 24, no. 4. Elsevier, pp. 178–185, 2008.","ista":"Kammenga JE, Phillips PC, de Bono M, Doroszuk A. 2008. Beyond induced mutants: using worms to study natural variation in genetic pathways. Trends in Genetics. 24(4), 178–185.","mla":"Kammenga, Jan E., et al. “Beyond Induced Mutants: Using Worms to Study Natural Variation in Genetic Pathways.” <i>Trends in Genetics</i>, vol. 24, no. 4, Elsevier, 2008, pp. 178–85, doi:<a href=\"https://doi.org/10.1016/j.tig.2008.01.001\">10.1016/j.tig.2008.01.001</a>."},"title":"Beyond induced mutants: using worms to study natural variation in genetic pathways"},{"publication_status":"published","volume":23,"article_processing_charge":"No","issue":"10","_id":"12201","abstract":[{"lang":"eng","text":"The development of plant lateral organs is interesting because, although many of the same genes seem to be involved in the early growth of primordia, completely different gene combinations are required for the complete development of organs such as leaves and stamens. Thus, the genes common to the development of most organs, which generally form and polarize the primordial ‘envelope’, must at some stage interact with those that ‘install’ the functional content of the organ – in the case of the stamen, the four microsporangia. Although distinct genetic pathways of organ initiation, polarity establishment and setting up the reproductive cell line can readily be recognized, they do not occur sequentially. Rather, they are activated early and run in parallel. There is evidence for continuing crosstalk between these pathways."}],"date_published":"2007-10-01T00:00:00Z","external_id":{"pmid":["17825943"]},"scopus_import":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2023-05-08T10:58:47Z","publication_identifier":{"issn":["0168-9525"]},"article_type":"original","oa_version":"None","year":"2007","publisher":"Elsevier BV","publication":"Trends in Genetics","department":[{"_id":"XiFe"}],"quality_controlled":"1","intvolume":"        23","status":"public","page":"503-510","month":"10","extern":"1","date_created":"2023-01-16T09:22:44Z","pmid":1,"acknowledgement":"X.F. holds a Clarendon Scholarship from the University of Oxford. We thank Angela Hay and Jill Harrison for helpful advice and discussion.","keyword":["Genetics"],"language":[{"iso":"eng"}],"doi":"10.1016/j.tig.2007.08.005","citation":{"mla":"Feng, Xiaoqi, and Hugh G. Dickinson. “Packaging the Male Germline in Plants.” <i>Trends in Genetics</i>, vol. 23, no. 10, Elsevier BV, 2007, pp. 503–10, doi:<a href=\"https://doi.org/10.1016/j.tig.2007.08.005\">10.1016/j.tig.2007.08.005</a>.","ieee":"X. Feng and H. G. Dickinson, “Packaging the male germline in plants,” <i>Trends in Genetics</i>, vol. 23, no. 10. Elsevier BV, pp. 503–510, 2007.","ista":"Feng X, Dickinson HG. 2007. Packaging the male germline in plants. Trends in Genetics. 23(10), 503–510.","chicago":"Feng, Xiaoqi, and Hugh G. Dickinson. “Packaging the Male Germline in Plants.” <i>Trends in Genetics</i>. Elsevier BV, 2007. <a href=\"https://doi.org/10.1016/j.tig.2007.08.005\">https://doi.org/10.1016/j.tig.2007.08.005</a>.","apa":"Feng, X., &#38; Dickinson, H. G. (2007). Packaging the male germline in plants. <i>Trends in Genetics</i>. Elsevier BV. <a href=\"https://doi.org/10.1016/j.tig.2007.08.005\">https://doi.org/10.1016/j.tig.2007.08.005</a>","ama":"Feng X, Dickinson HG. Packaging the male germline in plants. <i>Trends in Genetics</i>. 2007;23(10):503-510. doi:<a href=\"https://doi.org/10.1016/j.tig.2007.08.005\">10.1016/j.tig.2007.08.005</a>","short":"X. Feng, H.G. Dickinson, Trends in Genetics 23 (2007) 503–510."},"title":"Packaging the male germline in plants","author":[{"orcid":"0000-0002-4008-1234","id":"e0164712-22ee-11ed-b12a-d80fcdf35958","first_name":"Xiaoqi","full_name":"Feng, Xiaoqi","last_name":"Feng"},{"last_name":"Dickinson","full_name":"Dickinson, Hugh G.","first_name":"Hugh G."}],"type":"journal_article"}]