@article{7744,
  author       = {Robinson, Matthew Richard and Wray, Naomi R. and Visscher, Peter M.},
  issn         = {0168-9525},
  journal      = {Trends in Genetics},
  number       = {4},
  pages        = {124--132},
  publisher    = {Elsevier},
  title        = {{Explaining additional genetic variation in complex traits}},
  doi          = {10.1016/j.tig.2014.02.003},
  volume       = {30},
  year         = {2014},
}

@article{6135,
  abstract     = {Many organisms have stress response pathways, components of which share homology with players in complex human disease pathways. Research on stress response in the nematode worm Caenorhabditis elegans has provided detailed insights into the genetic and molecular mechanisms underlying complex human diseases. In this review we focus on four different types of environmental stress responses – heat shock, oxidative stress, hypoxia, and osmotic stress – and on how these can be used to study the genetics of complex human diseases. All four types of responses involve the genetic machineries that underlie a number of complex human diseases such as cancer and neurodegenerative diseases, including Alzheimer's and Parkinson's. We highlight the types of stress response experiments required to detect the genes and pathways underlying human disease and suggest that studying stress biology in worms can be translated to understanding human disease and provide potential targets for drug discovery.},
  author       = {Rodriguez, Miriam and Snoek, L. Basten and de Bono, Mario and Kammenga, Jan E.},
  issn         = {0168-9525},
  journal      = {Trends in Genetics},
  number       = {6},
  pages        = {367--374},
  publisher    = {Elsevier},
  title        = {{Worms under stress: C. elegans stress response and its relevance to complex human disease and aging}},
  doi          = {10.1016/j.tig.2013.01.010},
  volume       = {29},
  year         = {2013},
}

@article{6148,
  author       = {Kammenga, Jan E. and Phillips, Patrick C. and de Bono, Mario and Doroszuk, Agnieszka},
  issn         = {0168-9525},
  journal      = {Trends in Genetics},
  number       = {4},
  pages        = {178--185},
  publisher    = {Elsevier},
  title        = {{Beyond induced mutants: using worms to study natural variation in genetic pathways}},
  doi          = {10.1016/j.tig.2008.01.001},
  volume       = {24},
  year         = {2008},
}

@article{12201,
  abstract     = {The development of plant lateral organs is interesting because, although many of the same genes seem to be involved in the early growth of primordia, completely different gene combinations are required for the complete development of organs such as leaves and stamens. Thus, the genes common to the development of most organs, which generally form and polarize the primordial ‘envelope’, must at some stage interact with those that ‘install’ the functional content of the organ – in the case of the stamen, the four microsporangia. Although distinct genetic pathways of organ initiation, polarity establishment and setting up the reproductive cell line can readily be recognized, they do not occur sequentially. Rather, they are activated early and run in parallel. There is evidence for continuing crosstalk between these pathways.},
  author       = {Feng, Xiaoqi and Dickinson, Hugh G.},
  issn         = {0168-9525},
  journal      = {Trends in Genetics},
  keywords     = {Genetics},
  number       = {10},
  pages        = {503--510},
  publisher    = {Elsevier BV},
  title        = {{Packaging the male germline in plants}},
  doi          = {10.1016/j.tig.2007.08.005},
  volume       = {23},
  year         = {2007},
}