---
_id: '2573'
abstract:
- lang: eng
  text: Developmental changes of the distribution pattern of substance P receptor
    (SPR) were investigated immunohistochemically in the rat striatum. The SPR immunoreactivity
    in the striatum first emerged at postnatal day 1 and transiently showed a patchy
    pattern of distribution until it displayed the adult pattern of homogeneous distribution
    by the end of the third postnatal week. The SPR-immunoreactive patches were most
    marked in the medial and dorsolateral parts of the striatum, as well as in the
    subcallosal streak. They matched tyrosine hydroxylase-enriched areas and, conversely,
    avoided calbindin-enriched zones. No neurons within the SPR-immunoreactive patches
    contained either choline acetyltransferase or somatostatin, which is known to
    be contained in intrinsic neurons in the striatum. The vast majority of SPR-immunoreactive
    patch neurons also contained DARPP-32, a phosphoprotein that is expressed in striatal
    projection neurons with D1 dopamine receptor. The results indicate that SPR-immunoreactive
    patches which appear transiently in the developing striatum are in register with
    the striatal patch compartment, and that SPR immunoreactivity within these patches
    may be expressed on projection neurons rather than intrinsic neurons. Such SPR
    immunoreactivity in projection neurons in striatal patches may fade out in adulthood.
acknowledgement: "We thank Mr. Akira Uesugi and Ms. Miao-Li Zhang for their photographic
  help. We are also grateful for the support of Dr. Kajitaro Morita in the Morita
  Clinic of Internal Medicine and Pediatrics at Kadoma, Osaka, Japan, and for the
  support of Drs. Satoru Fukuchi, Ritsu Hayashi, Sozaburo Hayashi, Mizuho Katsurada,
  Yutaka Kitani, Keiko Kumagai, Toshihiko Kuroda., Hiroshi Matsubara, Hiroshi Matsushita,
  Chisato Minakuchi, Gonpei Niwa, Hajime Oda, Masahiko Ohbayashi, Sei-ichi Ohbayashi,
  Hiroyasu Ohtsuka, Shigeo Tamaki, Eizo Watanabe, Kazuo Yoshino, and Toshiaki Yoshino.
  This work was supported in part by Grants-in-Aid for Special Research on Priority
  Areas 05267104, Scientific Research (B) \r\n5454658, and Scientific Research (C)
  05680658 and 06680735 from the Ministry of Education, Science and Culture of Japan."
article_processing_charge: No
article_type: original
author:
- first_name: Hironobu
  full_name: Tokuno, Hironobu
  last_name: Tokuno
- first_name: Masahiko
  full_name: Takada, Masahiko
  last_name: Takada
- first_name: Takeshi
  full_name: Kaneko, Takeshi
  last_name: Kaneko
- first_name: Ryuichi
  full_name: Shigemoto, Ryuichi
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
- first_name: Noboru
  full_name: Mizuno, Noboru
  last_name: Mizuno
citation:
  ama: Tokuno H, Takada M, Kaneko T, Shigemoto R, Mizuno N. Patchy distribution of
    substance P receptor immunoreactivity in the developing rat striatum. <i>Developmental
    Brain Research</i>. 1996;95(1):107-117. doi:<a href="https://doi.org/10.1016/0165-3806(96)00080-6">10.1016/0165-3806(96)00080-6</a>
  apa: Tokuno, H., Takada, M., Kaneko, T., Shigemoto, R., &#38; Mizuno, N. (1996).
    Patchy distribution of substance P receptor immunoreactivity in the developing
    rat striatum. <i>Developmental Brain Research</i>. Elsevier. <a href="https://doi.org/10.1016/0165-3806(96)00080-6">https://doi.org/10.1016/0165-3806(96)00080-6</a>
  chicago: Tokuno, Hironobu, Masahiko Takada, Takeshi Kaneko, Ryuichi Shigemoto, and
    Noboru Mizuno. “Patchy Distribution of Substance P Receptor Immunoreactivity in
    the Developing Rat Striatum.” <i>Developmental Brain Research</i>. Elsevier, 1996.
    <a href="https://doi.org/10.1016/0165-3806(96)00080-6">https://doi.org/10.1016/0165-3806(96)00080-6</a>.
  ieee: H. Tokuno, M. Takada, T. Kaneko, R. Shigemoto, and N. Mizuno, “Patchy distribution
    of substance P receptor immunoreactivity in the developing rat striatum,” <i>Developmental
    Brain Research</i>, vol. 95, no. 1. Elsevier, pp. 107–117, 1996.
  ista: Tokuno H, Takada M, Kaneko T, Shigemoto R, Mizuno N. 1996. Patchy distribution
    of substance P receptor immunoreactivity in the developing rat striatum. Developmental
    Brain Research. 95(1), 107–117.
  mla: Tokuno, Hironobu, et al. “Patchy Distribution of Substance P Receptor Immunoreactivity
    in the Developing Rat Striatum.” <i>Developmental Brain Research</i>, vol. 95,
    no. 1, Elsevier, 1996, pp. 107–17, doi:<a href="https://doi.org/10.1016/0165-3806(96)00080-6">10.1016/0165-3806(96)00080-6</a>.
  short: H. Tokuno, M. Takada, T. Kaneko, R. Shigemoto, N. Mizuno, Developmental Brain
    Research 95 (1996) 107–117.
date_created: 2018-12-11T11:58:28Z
date_published: 1996-08-20T00:00:00Z
date_updated: 2022-08-11T12:07:34Z
day: '20'
doi: 10.1016/0165-3806(96)00080-6
extern: '1'
external_id:
  pmid:
  - '8873981 '
intvolume: '        95'
issue: '1'
language:
- iso: eng
month: '08'
oa_version: None
page: 107 - 117
pmid: 1
publication: Developmental Brain Research
publication_identifier:
  issn:
  - 0165-3806
publication_status: published
publisher: Elsevier
publist_id: '4325'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Patchy distribution of substance P receptor immunoreactivity in the developing
  rat striatum
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 95
year: '1996'
...