---
_id: '8454'
abstract:
- lang: eng
  text: Magic-angle spinning solid-state NMR spectroscopy is an important technique
    to study molecular structure, dynamics and interactions, and is rapidly gaining
    importance in biomolecular sciences. Here we provide an overview of experimental
    approaches to study molecular dynamics by MAS solid-state NMR, with an emphasis
    on the underlying theoretical concepts and differences of MAS solid-state NMR
    compared to solution-state NMR. The theoretical foundations of nuclear spin relaxation
    are revisited, focusing on the particularities of spin relaxation in solid samples
    under magic-angle spinning. We discuss the range of validity of Redfield theory,
    as well as the inherent multi-exponential behavior of relaxation in solids. Experimental
    challenges for measuring relaxation parameters in MAS solid-state NMR and a few
    recently proposed relaxation approaches are discussed, which provide information
    about time scales and amplitudes of motions ranging from picoseconds to milliseconds.
    We also discuss the theoretical basis and experimental measurements of anisotropic
    interactions (chemical-shift anisotropies, dipolar and quadrupolar couplings),
    which give direct information about the amplitude of motions. The potential of
    combining relaxation data with such measurements of dynamically-averaged anisotropic
    interactions is discussed. Although the focus of this review is on the theoretical
    foundations of dynamics studies rather than their application, we close by discussing
    a small number of recent dynamics studies, where the dynamic properties of proteins
    in crystals are compared to those in solution.
article_processing_charge: No
article_type: original
author:
- first_name: Paul
  full_name: Schanda, Paul
  id: 7B541462-FAF6-11E9-A490-E8DFE5697425
  last_name: Schanda
  orcid: 0000-0002-9350-7606
- first_name: Matthias
  full_name: Ernst, Matthias
  last_name: Ernst
citation:
  ama: 'Schanda P, Ernst M. Studying dynamics by magic-angle spinning solid-state
    NMR spectroscopy: Principles and applications to biomolecules. <i>Progress in
    Nuclear Magnetic Resonance Spectroscopy</i>. 2016;96(8):1-46. doi:<a href="https://doi.org/10.1016/j.pnmrs.2016.02.001">10.1016/j.pnmrs.2016.02.001</a>'
  apa: 'Schanda, P., &#38; Ernst, M. (2016). Studying dynamics by magic-angle spinning
    solid-state NMR spectroscopy: Principles and applications to biomolecules. <i>Progress
    in Nuclear Magnetic Resonance Spectroscopy</i>. Elsevier. <a href="https://doi.org/10.1016/j.pnmrs.2016.02.001">https://doi.org/10.1016/j.pnmrs.2016.02.001</a>'
  chicago: 'Schanda, Paul, and Matthias Ernst. “Studying Dynamics by Magic-Angle Spinning
    Solid-State NMR Spectroscopy: Principles and Applications to Biomolecules.” <i>Progress
    in Nuclear Magnetic Resonance Spectroscopy</i>. Elsevier, 2016. <a href="https://doi.org/10.1016/j.pnmrs.2016.02.001">https://doi.org/10.1016/j.pnmrs.2016.02.001</a>.'
  ieee: 'P. Schanda and M. Ernst, “Studying dynamics by magic-angle spinning solid-state
    NMR spectroscopy: Principles and applications to biomolecules,” <i>Progress in
    Nuclear Magnetic Resonance Spectroscopy</i>, vol. 96, no. 8. Elsevier, pp. 1–46,
    2016.'
  ista: 'Schanda P, Ernst M. 2016. Studying dynamics by magic-angle spinning solid-state
    NMR spectroscopy: Principles and applications to biomolecules. Progress in Nuclear
    Magnetic Resonance Spectroscopy. 96(8), 1–46.'
  mla: 'Schanda, Paul, and Matthias Ernst. “Studying Dynamics by Magic-Angle Spinning
    Solid-State NMR Spectroscopy: Principles and Applications to Biomolecules.” <i>Progress
    in Nuclear Magnetic Resonance Spectroscopy</i>, vol. 96, no. 8, Elsevier, 2016,
    pp. 1–46, doi:<a href="https://doi.org/10.1016/j.pnmrs.2016.02.001">10.1016/j.pnmrs.2016.02.001</a>.'
  short: P. Schanda, M. Ernst, Progress in Nuclear Magnetic Resonance Spectroscopy
    96 (2016) 1–46.
date_created: 2020-09-18T10:07:17Z
date_published: 2016-08-01T00:00:00Z
date_updated: 2021-01-12T08:19:23Z
day: '01'
doi: 10.1016/j.pnmrs.2016.02.001
extern: '1'
intvolume: '        96'
issue: '8'
language:
- iso: eng
month: '08'
oa_version: None
page: 1-46
publication: Progress in Nuclear Magnetic Resonance Spectroscopy
publication_identifier:
  issn:
  - 0079-6565
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: 'Studying dynamics by magic-angle spinning solid-state NMR spectroscopy: Principles
  and applications to biomolecules'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 96
year: '2016'
...
---
_id: '8475'
article_processing_charge: No
article_type: original
author:
- first_name: Paul
  full_name: Schanda, Paul
  id: 7B541462-FAF6-11E9-A490-E8DFE5697425
  last_name: Schanda
  orcid: 0000-0002-9350-7606
citation:
  ama: 'Schanda P. Fast-pulsing longitudinal relaxation optimized techniques: Enriching
    the toolbox of fast biomolecular NMR spectroscopy. <i>Progress in Nuclear Magnetic
    Resonance Spectroscopy</i>. 2009;55(3):238-265. doi:<a href="https://doi.org/10.1016/j.pnmrs.2009.05.002">10.1016/j.pnmrs.2009.05.002</a>'
  apa: 'Schanda, P. (2009). Fast-pulsing longitudinal relaxation optimized techniques:
    Enriching the toolbox of fast biomolecular NMR spectroscopy. <i>Progress in Nuclear
    Magnetic Resonance Spectroscopy</i>. Elsevier. <a href="https://doi.org/10.1016/j.pnmrs.2009.05.002">https://doi.org/10.1016/j.pnmrs.2009.05.002</a>'
  chicago: 'Schanda, Paul. “Fast-Pulsing Longitudinal Relaxation Optimized Techniques:
    Enriching the Toolbox of Fast Biomolecular NMR Spectroscopy.” <i>Progress in Nuclear
    Magnetic Resonance Spectroscopy</i>. Elsevier, 2009. <a href="https://doi.org/10.1016/j.pnmrs.2009.05.002">https://doi.org/10.1016/j.pnmrs.2009.05.002</a>.'
  ieee: 'P. Schanda, “Fast-pulsing longitudinal relaxation optimized techniques: Enriching
    the toolbox of fast biomolecular NMR spectroscopy,” <i>Progress in Nuclear Magnetic
    Resonance Spectroscopy</i>, vol. 55, no. 3. Elsevier, pp. 238–265, 2009.'
  ista: 'Schanda P. 2009. Fast-pulsing longitudinal relaxation optimized techniques:
    Enriching the toolbox of fast biomolecular NMR spectroscopy. Progress in Nuclear
    Magnetic Resonance Spectroscopy. 55(3), 238–265.'
  mla: 'Schanda, Paul. “Fast-Pulsing Longitudinal Relaxation Optimized Techniques:
    Enriching the Toolbox of Fast Biomolecular NMR Spectroscopy.” <i>Progress in Nuclear
    Magnetic Resonance Spectroscopy</i>, vol. 55, no. 3, Elsevier, 2009, pp. 238–65,
    doi:<a href="https://doi.org/10.1016/j.pnmrs.2009.05.002">10.1016/j.pnmrs.2009.05.002</a>.'
  short: P. Schanda, Progress in Nuclear Magnetic Resonance Spectroscopy 55 (2009)
    238–265.
date_created: 2020-09-18T10:11:42Z
date_published: 2009-10-01T00:00:00Z
date_updated: 2021-01-12T08:19:32Z
day: '01'
doi: 10.1016/j.pnmrs.2009.05.002
extern: '1'
intvolume: '        55'
issue: '3'
language:
- iso: eng
month: '10'
oa_version: None
page: 238-265
publication: Progress in Nuclear Magnetic Resonance Spectroscopy
publication_identifier:
  issn:
  - 0079-6565
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: 'Fast-pulsing longitudinal relaxation optimized techniques: Enriching the toolbox
  of fast biomolecular NMR spectroscopy'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 55
year: '2009'
...