---
_id: '7410'
abstract:
- lang: eng
  text: 'Epiboly is a conserved gastrulation movement describing the thinning and
    spreading of a sheet or multi-layer of cells. The zebrafish embryo has emerged
    as a vital model system to address the cellular and molecular mechanisms that
    drive epiboly. In the zebrafish embryo, the blastoderm, consisting of a simple
    squamous epithelium (the enveloping layer) and an underlying mass of deep cells,
    as well as a yolk nuclear syncytium (the yolk syncytial layer) undergo epiboly
    to internalize the yolk cell during gastrulation. The major events during zebrafish
    epiboly are: expansion of the enveloping layer and the internal yolk syncytial
    layer, reduction and removal of the yolk membrane ahead of the advancing blastoderm
    margin and deep cell rearrangements between the enveloping layer and yolk syncytial
    layer to thin the blastoderm. Here, work addressing the cellular and molecular
    mechanisms as well as the sources of the mechanical forces that underlie these
    events is reviewed. The contribution of recent findings to the current model of
    epiboly as well as open questions and future prospects are also discussed.'
article_processing_charge: No
author:
- first_name: Ashley E.E.
  full_name: Bruce, Ashley E.E.
  last_name: Bruce
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
citation:
  ama: 'Bruce AEE, Heisenberg C-PJ. Mechanisms of zebrafish epiboly: A current view.
    In: Solnica-Krezel L, ed. <i>Gastrulation: From Embryonic Pattern to Form</i>.
    Vol 136. Current Topics in Developmental Biology. Elsevier; 2020:319-341. doi:<a
    href="https://doi.org/10.1016/bs.ctdb.2019.07.001">10.1016/bs.ctdb.2019.07.001</a>'
  apa: 'Bruce, A. E. E., &#38; Heisenberg, C.-P. J. (2020). Mechanisms of zebrafish
    epiboly: A current view. In L. Solnica-Krezel (Ed.), <i>Gastrulation: From Embryonic
    Pattern to Form</i> (Vol. 136, pp. 319–341). Elsevier. <a href="https://doi.org/10.1016/bs.ctdb.2019.07.001">https://doi.org/10.1016/bs.ctdb.2019.07.001</a>'
  chicago: 'Bruce, Ashley E.E., and Carl-Philipp J Heisenberg. “Mechanisms of Zebrafish
    Epiboly: A Current View.” In <i>Gastrulation: From Embryonic Pattern to Form</i>,
    edited by Lilianna  Solnica-Krezel, 136:319–41. Current Topics in Developmental
    Biology. Elsevier, 2020. <a href="https://doi.org/10.1016/bs.ctdb.2019.07.001">https://doi.org/10.1016/bs.ctdb.2019.07.001</a>.'
  ieee: 'A. E. E. Bruce and C.-P. J. Heisenberg, “Mechanisms of zebrafish epiboly:
    A current view,” in <i>Gastrulation: From Embryonic Pattern to Form</i>, vol.
    136, L. Solnica-Krezel, Ed. Elsevier, 2020, pp. 319–341.'
  ista: 'Bruce AEE, Heisenberg C-PJ. 2020.Mechanisms of zebrafish epiboly: A current
    view. In: Gastrulation: From Embryonic Pattern to Form. vol. 136, 319–341.'
  mla: 'Bruce, Ashley E. E., and Carl-Philipp J. Heisenberg. “Mechanisms of Zebrafish
    Epiboly: A Current View.” <i>Gastrulation: From Embryonic Pattern to Form</i>,
    edited by Lilianna  Solnica-Krezel, vol. 136, Elsevier, 2020, pp. 319–41, doi:<a
    href="https://doi.org/10.1016/bs.ctdb.2019.07.001">10.1016/bs.ctdb.2019.07.001</a>.'
  short: 'A.E.E. Bruce, C.-P.J. Heisenberg, in:, L. Solnica-Krezel (Ed.), Gastrulation:
    From Embryonic Pattern to Form, Elsevier, 2020, pp. 319–341.'
date_created: 2020-01-30T09:24:06Z
date_published: 2020-01-01T00:00:00Z
date_updated: 2024-02-22T13:23:09Z
day: '01'
department:
- _id: CaHe
doi: 10.1016/bs.ctdb.2019.07.001
editor:
- first_name: 'Lilianna '
  full_name: 'Solnica-Krezel, Lilianna '
  last_name: Solnica-Krezel
external_id:
  isi:
  - '000611830600012'
intvolume: '       136'
isi: 1
language:
- iso: eng
month: '01'
oa_version: None
page: 319-341
publication: 'Gastrulation: From Embryonic Pattern to Form'
publication_identifier:
  isbn:
  - '9780128127988'
  issn:
  - 0070-2153
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
series_title: Current Topics in Developmental Biology
status: public
title: 'Mechanisms of zebrafish epiboly: A current view'
type: book_chapter
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 136
year: '2020'
...