[{"pmid":1,"acknowledgement":"The authors would like to thank Feyza Nur Arslan, Suyash Naik, Diana Pinheiro, Alexandra Schauer, and Shayan Shamipour for their comments on the draft. N.M. is supported by an ISTplus postdoctoral fellowship (H2020 Marie-Sklodowska-Curie COFUND Action).","department":[{"_id":"CaHe"}],"date_created":"2021-12-05T23:01:41Z","keyword":["morphogenesis","forward genetics","high-resolution microscopy","biophysics","biochemistry","patterning"],"intvolume":"        55","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","article_processing_charge":"No","quality_controlled":"1","publication_identifier":{"eissn":["1545-2948"],"issn":["0066-4197"]},"month":"08","volume":55,"article_type":"original","isi":1,"publisher":"Annual Reviews","year":"2021","language":[{"iso":"eng"}],"doi":"10.1146/annurev-genet-071819-103748","type":"journal_article","_id":"10406","author":[{"orcid":"0000-0002-6425-5788","last_name":"Mishra","id":"C4D70E82-1081-11EA-B3ED-9A4C3DDC885E","first_name":"Nikhil","full_name":"Mishra, Nikhil"},{"first_name":"Carl-Philipp J","full_name":"Heisenberg, Carl-Philipp J","last_name":"Heisenberg","id":"39427864-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0912-4566"}],"date_published":"2021-08-30T00:00:00Z","project":[{"call_identifier":"H2020","grant_number":"754411","name":"ISTplus - Postdoctoral Fellowships","_id":"260C2330-B435-11E9-9278-68D0E5697425"}],"citation":{"apa":"Mishra, N., &#38; Heisenberg, C.-P. J. (2021). Dissecting organismal morphogenesis by bridging genetics and biophysics. <i>Annual Review of Genetics</i>. Annual Reviews. <a href=\"https://doi.org/10.1146/annurev-genet-071819-103748\">https://doi.org/10.1146/annurev-genet-071819-103748</a>","ista":"Mishra N, Heisenberg C-PJ. 2021. Dissecting organismal morphogenesis by bridging genetics and biophysics. Annual Review of Genetics. 55, 209–233.","short":"N. Mishra, C.-P.J. Heisenberg, Annual Review of Genetics 55 (2021) 209–233.","mla":"Mishra, Nikhil, and Carl-Philipp J. Heisenberg. “Dissecting Organismal Morphogenesis by Bridging Genetics and Biophysics.” <i>Annual Review of Genetics</i>, vol. 55, Annual Reviews, 2021, pp. 209–33, doi:<a href=\"https://doi.org/10.1146/annurev-genet-071819-103748\">10.1146/annurev-genet-071819-103748</a>.","ama":"Mishra N, Heisenberg C-PJ. Dissecting organismal morphogenesis by bridging genetics and biophysics. <i>Annual Review of Genetics</i>. 2021;55:209-233. doi:<a href=\"https://doi.org/10.1146/annurev-genet-071819-103748\">10.1146/annurev-genet-071819-103748</a>","chicago":"Mishra, Nikhil, and Carl-Philipp J Heisenberg. “Dissecting Organismal Morphogenesis by Bridging Genetics and Biophysics.” <i>Annual Review of Genetics</i>. Annual Reviews, 2021. <a href=\"https://doi.org/10.1146/annurev-genet-071819-103748\">https://doi.org/10.1146/annurev-genet-071819-103748</a>.","ieee":"N. Mishra and C.-P. J. Heisenberg, “Dissecting organismal morphogenesis by bridging genetics and biophysics,” <i>Annual Review of Genetics</i>, vol. 55. Annual Reviews, pp. 209–233, 2021."},"scopus_import":"1","external_id":{"isi":["000747220900010"],"pmid":["34460295"]},"title":"Dissecting organismal morphogenesis by bridging genetics and biophysics","publication":"Annual Review of Genetics","date_updated":"2023-08-14T13:05:13Z","status":"public","ec_funded":1,"abstract":[{"lang":"eng","text":"Multicellular organisms develop complex shapes from much simpler, single-celled zygotes through a process commonly called morphogenesis. Morphogenesis involves an interplay between several factors, ranging from the gene regulatory networks determining cell fate and differentiation to the mechanical processes underlying cell and tissue shape changes. Thus, the study of morphogenesis has historically been based on multidisciplinary approaches at the interface of biology with physics and mathematics. Recent technological advances have further improved our ability to study morphogenesis by bridging the gap between the genetic and biophysical factors through the development of new tools for visualizing, analyzing, and perturbing these factors and their biochemical intermediaries. Here, we review how a combination of genetic, microscopic, biophysical, and biochemical approaches has aided our attempts to understand morphogenesis and discuss potential approaches that may be beneficial to such an inquiry in the future."}],"page":"209-233","oa_version":"None","publication_status":"published","day":"30"},{"date_published":"1989-01-01T00:00:00Z","oa_version":"None","publication_status":"published","page":"337 - 370","day":"01","_id":"4312","author":[{"full_name":"Barton, Nicholas H","first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","last_name":"Barton","orcid":"0000-0002-8548-5240"},{"last_name":"Turelli","full_name":"Turelli, Michael","first_name":"Michael"}],"type":"journal_article","status":"public","publisher":"Annual Reviews","date_updated":"2022-02-09T16:01:46Z","year":"1989","language":[{"iso":"eng"}],"doi":"10.1146/annurev.ge.23.120189.002005","volume":23,"article_type":"original","title":"Evolutionary quantitative genetics: how little do we know?","publication":"Annual Review of Genetics","quality_controlled":"1","main_file_link":[{"url":"https://www.annualreviews.org/doi/10.1146/annurev.ge.23.120189.002005"}],"publist_id":"1744","publication_identifier":{"issn":["0066-4197"],"eissn":["1545-2948"]},"month":"01","intvolume":"        23","extern":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","citation":{"mla":"Barton, Nicholas H., and Michael Turelli. “Evolutionary Quantitative Genetics: How Little Do We Know?” <i>Annual Review of Genetics</i>, vol. 23, Annual Reviews, 1989, pp. 337–70, doi:<a href=\"https://doi.org/10.1146/annurev.ge.23.120189.002005\">10.1146/annurev.ge.23.120189.002005</a>.","short":"N.H. Barton, M. Turelli, Annual Review of Genetics 23 (1989) 337–370.","ista":"Barton NH, Turelli M. 1989. Evolutionary quantitative genetics: how little do we know? Annual Review of Genetics. 23, 337–370.","apa":"Barton, N. H., &#38; Turelli, M. (1989). Evolutionary quantitative genetics: how little do we know? <i>Annual Review of Genetics</i>. Annual Reviews. <a href=\"https://doi.org/10.1146/annurev.ge.23.120189.002005\">https://doi.org/10.1146/annurev.ge.23.120189.002005</a>","ama":"Barton NH, Turelli M. Evolutionary quantitative genetics: how little do we know? <i>Annual Review of Genetics</i>. 1989;23:337-370. doi:<a href=\"https://doi.org/10.1146/annurev.ge.23.120189.002005\">10.1146/annurev.ge.23.120189.002005</a>","chicago":"Barton, Nicholas H, and Michael Turelli. “Evolutionary Quantitative Genetics: How Little Do We Know?” <i>Annual Review of Genetics</i>. Annual Reviews, 1989. <a href=\"https://doi.org/10.1146/annurev.ge.23.120189.002005\">https://doi.org/10.1146/annurev.ge.23.120189.002005</a>.","ieee":"N. H. Barton and M. Turelli, “Evolutionary quantitative genetics: how little do we know?,” <i>Annual Review of Genetics</i>, vol. 23. Annual Reviews, pp. 337–370, 1989."},"acknowledgement":"We thank G. E. Bradford, B. Charlesworth, J. A. Coyne, D. Currie, H. Dingle, J. H. Gillespie, A. Gimelfarb, W. G. Hill, A. A. Hoffmann, K. S. Jackson, J. S. Jones, A. Liebowiz, T. Mitchell-aids , T. A. Mousseau, J. Peck, T. Prout, B. Riska, D. A. Roff, H. B. Shaffer, and M. Slatkin for helpful discussions and comments on earlier drafts. Our research is supported\r\nin part by grants from the Science and Engineering Research Council, the National Science Foundation (BSR-8866548), and the Institute of Theoretical Dynamics at University of California, Davis.","date_created":"2018-12-11T12:08:11Z"}]