---
_id: '2579'
abstract:
- lang: eng
  text: The localisation of the neurokinin 3 receptor (NK3r) in the rat gastrointestinal
    tract has been studied by using a polyclonal antiserum against the C-terminal
    portion (amino acids 388-452) of the rat NK3r. In the oesophagus, immunoreactivity
    for the NK3r was found on smooth muscle cells of the muscularis mucosae. NK3r
    immunoreactivity was not present on muscle cells of other regions. Nerve cell
    bodies immunoreactive for NK3r were seen in the myenteric and submucous plexuses
    of the small and large intestine, but not in the stomach or oesophagus. Immunoreactivity
    was largely confined to nerve cell surfaces. The reaction product was on the cell
    soma and initial parts of axons. Reactivity was not seen on nerve terminals. Immunoreactive
    nerve cells had Dogiel Type II morphology. Patterns of co-localisation of NK3r
    and immunoreactivity for other markers were examined in the ileum, to provide
    a basis from which to deduce the functional identity of NK3r-immunoreactive nerve
    cells. Most of the NK3r-immunoreactive nerve cells were also immunoreactive for
    the calcium-binding proteins, calretinin and calbindin, and all were immunoreactive
    for the NK1 receptor (NK1r). Nerve cells that were immunoreactive for nitric oxide
    synthase were not immunoreactive for either NK3r or NK1r. The projections of the
    calbindin and calretinin neurons were determined by nerve lesion studies. Their
    morphology, projections to the mucosa and other ganglia and immunoreactivity for
    the calcium-binding proteins suggest that the NK3r-immunoreactive neurons are
    intrinsic sensory neurons.
acknowledgement: This work was supported by grants from the National Health and Medical
  Research Council of Australia and the National Science Foundation of the Peoples
  Republic of China. Patricia Mann is a holder of a Gastroenterological Society of
  Australia Post-Graduate Scholarship.
article_processing_charge: No
article_type: original
author:
- first_name: Patricia
  full_name: Mann, Patricia
  last_name: Mann
- first_name: Bridget
  full_name: Southwell, Bridget
  last_name: Southwell
- first_name: Yu
  full_name: Ding, Yu
  last_name: Ding
- first_name: Ryuichi
  full_name: Shigemoto, Ryuichi
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
- first_name: Noboru
  full_name: Mizuno, Noboru
  last_name: Mizuno
- first_name: John
  full_name: Furness, John
  last_name: Furness
citation:
  ama: Mann P, Southwell B, Ding Y, Shigemoto R, Mizuno N, Furness J. Localisation
    of neurokinin 3 (NK3) receptor immunoreactivity in the rat gastrointestinal tract.
    <i>Cell and Tissue Research</i>. 1997;289(1):1-9. doi:<a href="https://doi.org/10.1007/s004410050846">10.1007/s004410050846</a>
  apa: Mann, P., Southwell, B., Ding, Y., Shigemoto, R., Mizuno, N., &#38; Furness,
    J. (1997). Localisation of neurokinin 3 (NK3) receptor immunoreactivity in the
    rat gastrointestinal tract. <i>Cell and Tissue Research</i>. Springer. <a href="https://doi.org/10.1007/s004410050846">https://doi.org/10.1007/s004410050846</a>
  chicago: Mann, Patricia, Bridget Southwell, Yu Ding, Ryuichi Shigemoto, Noboru Mizuno,
    and John Furness. “Localisation of Neurokinin 3 (NK3) Receptor Immunoreactivity
    in the Rat Gastrointestinal Tract.” <i>Cell and Tissue Research</i>. Springer,
    1997. <a href="https://doi.org/10.1007/s004410050846">https://doi.org/10.1007/s004410050846</a>.
  ieee: P. Mann, B. Southwell, Y. Ding, R. Shigemoto, N. Mizuno, and J. Furness, “Localisation
    of neurokinin 3 (NK3) receptor immunoreactivity in the rat gastrointestinal tract,”
    <i>Cell and Tissue Research</i>, vol. 289, no. 1. Springer, pp. 1–9, 1997.
  ista: Mann P, Southwell B, Ding Y, Shigemoto R, Mizuno N, Furness J. 1997. Localisation
    of neurokinin 3 (NK3) receptor immunoreactivity in the rat gastrointestinal tract.
    Cell and Tissue Research. 289(1), 1–9.
  mla: Mann, Patricia, et al. “Localisation of Neurokinin 3 (NK3) Receptor Immunoreactivity
    in the Rat Gastrointestinal Tract.” <i>Cell and Tissue Research</i>, vol. 289,
    no. 1, Springer, 1997, pp. 1–9, doi:<a href="https://doi.org/10.1007/s004410050846">10.1007/s004410050846</a>.
  short: P. Mann, B. Southwell, Y. Ding, R. Shigemoto, N. Mizuno, J. Furness, Cell
    and Tissue Research 289 (1997) 1–9.
date_created: 2018-12-11T11:58:29Z
date_published: 1997-06-01T00:00:00Z
date_updated: 2022-08-22T12:19:10Z
day: '01'
doi: 10.1007/s004410050846
extern: '1'
external_id:
  pmid:
  - '9182595'
intvolume: '       289'
issue: '1'
language:
- iso: eng
month: '06'
oa_version: None
page: 1 - 9
pmid: 1
publication: Cell and Tissue Research
publication_identifier:
  issn:
  - 0044-3794
publication_status: published
publisher: Springer
publist_id: '4319'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Localisation of neurokinin 3 (NK3) receptor immunoreactivity in the rat gastrointestinal
  tract
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 289
year: '1997'
...