---
_id: '4210'
abstract:
- lang: eng
  text: Mutations causing a visible phenotype in the adult serve as valuable visible
    genetic markers in multicellular genetic model organisms such as Drosophila melanogaster,
    Caenorhabditis elegans and Arabidopsis thaliana. In a large scale screen for mutations
    affecting early development of the zebrafish, we identified a number of mutations
    that are homozygous viable or semiviable. Here we describe viable mutations which
    produce visible phenotypes in the adult fish. These predominantly affect the fins
    and pigmentation, but also the eyes and body length of the adult. A number of
    dominant mutations caused visible phenotypes in the adult fish, Mutations in three
    genes, long fin, another long fin and wanda affected fin formation in the adult.
    Four mutations were found to cause a dominant reduction of the overall body length
    in the adult. The adult pigment pattern was found to be changed by dominant mutations
    in wanda, asterix, obelix, leopard, salz and pfeffer. Among the recessive mutations
    producing visible phenotypes in the homozygous adult, a group of mutations that
    failed to produce melanin was assayed for tyrosinase activity. Mutations in sandy
    produced embryos that failed to express tyrosinase activity. These are potentially
    useful for using tyrosinase as a marker for the generation of transgenic lines
    of zebrafish.
article_processing_charge: No
article_type: original
author:
- first_name: Pascal
  full_name: Haffter, Pascal
  last_name: Haffter
- first_name: Jörg
  full_name: Odenthal, Jörg
  last_name: Odenthal
- first_name: Mary
  full_name: Mullins, Mary
  last_name: Mullins
- first_name: Shuo
  full_name: Lin, Shuo
  last_name: Lin
- first_name: Michael
  full_name: Farrell, Michael
  last_name: Farrell
- first_name: Elisabeth
  full_name: Vogelsang, Elisabeth
  last_name: Vogelsang
- first_name: Fabian
  full_name: Haas, Fabian
  last_name: Haas
- first_name: Michael
  full_name: Brand, Michael
  last_name: Brand
- first_name: Fredericus
  full_name: Van Eeden, Fredericus
  last_name: Van Eeden
- first_name: Makoto
  full_name: Furutani Seiki, Makoto
  last_name: Furutani Seiki
- first_name: Michael
  full_name: Granato, Michael
  last_name: Granato
- first_name: Matthias
  full_name: Hammerschmidt, Matthias
  last_name: Hammerschmidt
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
- first_name: Yunjin
  full_name: Jiang, Yunjin
  last_name: Jiang
- first_name: Donald
  full_name: Kane, Donald
  last_name: Kane
- first_name: Robert
  full_name: Kelsh, Robert
  last_name: Kelsh
- first_name: Nancy
  full_name: Hopkins, Nancy
  last_name: Hopkins
- first_name: Christiane
  full_name: Nüsslein Volhard, Christiane
  last_name: Nüsslein Volhard
citation:
  ama: Haffter P, Odenthal J, Mullins M, et al. Mutations affecting pigmentation and
    shape of the adult zebrafish. <i>Development Genes and Evolution</i>. 1996;206(4):260-276.
    doi:<a href="https://doi.org/10.1007/s004270050051">10.1007/s004270050051</a>
  apa: Haffter, P., Odenthal, J., Mullins, M., Lin, S., Farrell, M., Vogelsang, E.,
    … Nüsslein Volhard, C. (1996). Mutations affecting pigmentation and shape of the
    adult zebrafish. <i>Development Genes and Evolution</i>. Springer. <a href="https://doi.org/10.1007/s004270050051">https://doi.org/10.1007/s004270050051</a>
  chicago: Haffter, Pascal, Jörg Odenthal, Mary Mullins, Shuo Lin, Michael Farrell,
    Elisabeth Vogelsang, Fabian Haas, et al. “Mutations Affecting Pigmentation and
    Shape of the Adult Zebrafish.” <i>Development Genes and Evolution</i>. Springer,
    1996. <a href="https://doi.org/10.1007/s004270050051">https://doi.org/10.1007/s004270050051</a>.
  ieee: P. Haffter <i>et al.</i>, “Mutations affecting pigmentation and shape of the
    adult zebrafish,” <i>Development Genes and Evolution</i>, vol. 206, no. 4. Springer,
    pp. 260–276, 1996.
  ista: Haffter P, Odenthal J, Mullins M, Lin S, Farrell M, Vogelsang E, Haas F, Brand
    M, Van Eeden F, Furutani Seiki M, Granato M, Hammerschmidt M, Heisenberg C-PJ,
    Jiang Y, Kane D, Kelsh R, Hopkins N, Nüsslein Volhard C. 1996. Mutations affecting
    pigmentation and shape of the adult zebrafish. Development Genes and Evolution.
    206(4), 260–276.
  mla: Haffter, Pascal, et al. “Mutations Affecting Pigmentation and Shape of the
    Adult Zebrafish.” <i>Development Genes and Evolution</i>, vol. 206, no. 4, Springer,
    1996, pp. 260–76, doi:<a href="https://doi.org/10.1007/s004270050051">10.1007/s004270050051</a>.
  short: P. Haffter, J. Odenthal, M. Mullins, S. Lin, M. Farrell, E. Vogelsang, F.
    Haas, M. Brand, F. Van Eeden, M. Furutani Seiki, M. Granato, M. Hammerschmidt,
    C.-P.J. Heisenberg, Y. Jiang, D. Kane, R. Kelsh, N. Hopkins, C. Nüsslein Volhard,
    Development Genes and Evolution 206 (1996) 260–276.
date_created: 2018-12-11T12:07:36Z
date_published: 1996-11-27T00:00:00Z
date_updated: 2022-08-04T14:45:21Z
day: '27'
doi: 10.1007/s004270050051
extern: '1'
external_id:
  pmid:
  - '24173565'
intvolume: '       206'
issue: '4'
language:
- iso: eng
month: '11'
oa_version: None
page: 260 - 276
pmid: 1
publication: Development Genes and Evolution
publication_identifier:
  issn:
  - 0043-5546
publication_status: published
publisher: Springer
publist_id: '1906'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mutations affecting pigmentation and shape of the adult zebrafish
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 206
year: '1996'
...