---
_id: '9454'
article_processing_charge: No
article_type: original
author:
- first_name: Simon W.-L.
full_name: Chan, Simon W.-L.
last_name: Chan
- first_name: Daniel
full_name: Zilberman, Daniel
id: 6973db13-dd5f-11ea-814e-b3e5455e9ed1
last_name: Zilberman
orcid: 0000-0002-0123-8649
- first_name: ' Zhixin'
full_name: Xie, Zhixin
last_name: Xie
- first_name: ' Lisa K.'
full_name: Johansen, Lisa K.
last_name: Johansen
- first_name: James C.
full_name: Carrington, James C.
last_name: Carrington
- first_name: Steven E.
full_name: Jacobsen, Steven E.
last_name: Jacobsen
citation:
ama: Chan SW-L, Zilberman D, Xie Zhixin, Johansen Lisa K., Carrington JC, Jacobsen
SE. RNA silencing genes control de novo DNA methylation. Science. 2004;303(5662):1336.
doi:10.1126/science.1095989
apa: Chan, S. W.-L., Zilberman, D., Xie, Zhixin, Johansen, Lisa K., Carrington,
J. C., & Jacobsen, S. E. (2004). RNA silencing genes control de novo DNA methylation.
Science. American Association for the Advancement of Science. https://doi.org/10.1126/science.1095989
chicago: Chan, Simon W.-L., Daniel Zilberman, Zhixin Xie, Lisa K. Johansen, James
C. Carrington, and Steven E. Jacobsen. “RNA Silencing Genes Control de Novo DNA
Methylation.” Science. American Association for the Advancement of Science,
2004. https://doi.org/10.1126/science.1095989.
ieee: S. W.-L. Chan, D. Zilberman, Zhixin Xie, Lisa K. Johansen, J. C. Carrington,
and S. E. Jacobsen, “RNA silencing genes control de novo DNA methylation,” Science,
vol. 303, no. 5662. American Association for the Advancement of Science, p. 1336,
2004.
ista: Chan SW-L, Zilberman D, Xie Zhixin, Johansen Lisa K., Carrington JC, Jacobsen
SE. 2004. RNA silencing genes control de novo DNA methylation. Science. 303(5662),
1336.
mla: Chan, Simon W. L., et al. “RNA Silencing Genes Control de Novo DNA Methylation.”
Science, vol. 303, no. 5662, American Association for the Advancement of
Science, 2004, p. 1336, doi:10.1126/science.1095989.
short: S.W.-L. Chan, D. Zilberman, Zhixin Xie, Lisa K. Johansen, J.C. Carrington,
S.E. Jacobsen, Science 303 (2004) 1336.
date_created: 2021-06-04T11:12:35Z
date_published: 2004-02-27T00:00:00Z
date_updated: 2021-12-14T09:13:53Z
day: '27'
department:
- _id: DaZi
doi: 10.1126/science.1095989
extern: '1'
external_id:
pmid:
- '14988555'
intvolume: ' 303'
issue: '5662'
keyword:
- Multidisciplinary
language:
- iso: eng
month: '02'
oa_version: None
page: '1336'
pmid: 1
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: RNA silencing genes control de novo DNA methylation
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 303
year: '2004'
...
---
_id: '9455'
abstract:
- lang: eng
text: Proteins of the ARGONAUTE family are important in diverse posttranscriptional
RNA-mediated gene-silencing systems as well as in transcriptional gene silencing
in Drosophila and fission yeast and in programmed DNA elimination in Tetrahymena.
We cloned ARGONAUTE4 (AGO4) from a screen for mutants that suppress silencing
of the Arabidopsis SUPERMAN(SUP) gene. The ago4-1 mutant reactivated silentSUP
alleles and decreased CpNpG and asymmetric DNA methylation as well as histone
H3 lysine-9 methylation. In addition,ago4-1 blocked histone and DNA methylation
and the accumulation of 25-nucleotide small interfering RNAs (siRNAs) that correspond
to the retroelement AtSN1. These results suggest that AGO4 and long siRNAs direct
chromatin modifications, including histone methylation and non-CpG DNA methylation.
article_processing_charge: No
article_type: original
author:
- first_name: Daniel
full_name: Zilberman, Daniel
id: 6973db13-dd5f-11ea-814e-b3e5455e9ed1
last_name: Zilberman
orcid: 0000-0002-0123-8649
- first_name: ' Xiaofeng'
full_name: Cao, Xiaofeng
last_name: Cao
- first_name: Steven E.
full_name: Jacobsen, Steven E.
last_name: Jacobsen
citation:
ama: Zilberman D, Cao Xiaofeng, Jacobsen SE. ARGONAUTE4 control of locus-specific
siRNA accumulation and DNA and histone methylation. Science. 2003;299(5607):716-719.
doi:10.1126/science.1079695
apa: Zilberman, D., Cao, Xiaofeng, & Jacobsen, S. E. (2003). ARGONAUTE4 control
of locus-specific siRNA accumulation and DNA and histone methylation. Science.
American Association for the Advancement of Science. https://doi.org/10.1126/science.1079695
chicago: Zilberman, Daniel, Xiaofeng Cao, and Steven E. Jacobsen. “ARGONAUTE4 Control
of Locus-Specific SiRNA Accumulation and DNA and Histone Methylation.” Science.
American Association for the Advancement of Science, 2003. https://doi.org/10.1126/science.1079695.
ieee: D. Zilberman, Xiaofeng Cao, and S. E. Jacobsen, “ARGONAUTE4 control of locus-specific
siRNA accumulation and DNA and histone methylation,” Science, vol. 299,
no. 5607. American Association for the Advancement of Science, pp. 716–719, 2003.
ista: Zilberman D, Cao Xiaofeng, Jacobsen SE. 2003. ARGONAUTE4 control of locus-specific
siRNA accumulation and DNA and histone methylation. Science. 299(5607), 716–719.
mla: Zilberman, Daniel, et al. “ARGONAUTE4 Control of Locus-Specific SiRNA Accumulation
and DNA and Histone Methylation.” Science, vol. 299, no. 5607, American
Association for the Advancement of Science, 2003, pp. 716–19, doi:10.1126/science.1079695.
short: D. Zilberman, Xiaofeng Cao, S.E. Jacobsen, Science 299 (2003) 716–719.
date_created: 2021-06-04T11:26:26Z
date_published: 2003-01-31T00:00:00Z
date_updated: 2021-12-14T08:43:30Z
day: '31'
department:
- _id: DaZi
doi: 10.1126/science.1079695
extern: '1'
external_id:
pmid:
- '12522258'
intvolume: ' 299'
issue: '5607'
keyword:
- Multidisciplinary
language:
- iso: eng
month: '01'
oa_version: None
page: 716-719
pmid: 1
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone
methylation
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 299
year: '2003'
...
---
_id: '4255'
abstract:
- lang: eng
text: 'Humans and their closest evolutionary relatives, the chimpanzees, differ
in ∼1.24% of their genomic DNA sequences. The fraction of these changes accumulated
during the speciation processes that have separated the two lineages may be of
special relevance in understanding the basis of their differences. We analyzed
human and chimpanzee sequence data to search for the patterns of divergence and
polymorphism predicted by a theoretical model of speciation. According to the
model, positively selected changes should accumulate in chromosomes that present
fixed structural differences, such as inversions, between the two species. Protein
evolution was more than 2.2 times faster in chromosomes that had undergone structural
rearrangements compared with colinear chromosomes. Also, nucleotide variability
is slightly lower in rearranged chromosomes. These patterns of divergence and
polymorphism may be, at least in part, the molecular footprint of speciation events
in the human and chimpanzee lineages. '
article_processing_charge: No
article_type: original
author:
- first_name: Arcadio
full_name: Navarro, Arcadio
last_name: Navarro
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Navarro A, Barton NH. Chromosomal speciation and molecular divergence -- Accelerated
evolution in rearranged chromosomes. Science. 2003;300(5617):321-324. doi:10.1126/science.1080600
apa: Navarro, A., & Barton, N. H. (2003). Chromosomal speciation and molecular
divergence -- Accelerated evolution in rearranged chromosomes. Science.
American Association for the Advancement of Science. https://doi.org/10.1126/science.1080600
chicago: Navarro, Arcadio, and Nicholas H Barton. “Chromosomal Speciation and Molecular
Divergence -- Accelerated Evolution in Rearranged Chromosomes.” Science.
American Association for the Advancement of Science, 2003. https://doi.org/10.1126/science.1080600 .
ieee: A. Navarro and N. H. Barton, “Chromosomal speciation and molecular divergence
-- Accelerated evolution in rearranged chromosomes,” Science, vol. 300,
no. 5617. American Association for the Advancement of Science, pp. 321–324, 2003.
ista: Navarro A, Barton NH. 2003. Chromosomal speciation and molecular divergence
-- Accelerated evolution in rearranged chromosomes. Science. 300(5617), 321–324.
mla: Navarro, Arcadio, and Nicholas H. Barton. “Chromosomal Speciation and Molecular
Divergence -- Accelerated Evolution in Rearranged Chromosomes.” Science,
vol. 300, no. 5617, American Association for the Advancement of Science, 2003,
pp. 321–24, doi:10.1126/science.1080600
.
short: A. Navarro, N.H. Barton, Science 300 (2003) 321–324.
date_created: 2018-12-11T12:07:53Z
date_published: 2003-04-11T00:00:00Z
date_updated: 2024-02-26T13:37:51Z
day: '11'
doi: '10.1126/science.1080600 '
extern: '1'
external_id:
pmid:
- ' 12690198'
intvolume: ' 300'
issue: '5617'
language:
- iso: eng
month: '04'
oa_version: None
page: 321 - 324
pmid: 1
publication: Science
publication_identifier:
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '1841'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Chromosomal speciation and molecular divergence -- Accelerated evolution in
rearranged chromosomes
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 300
year: '2003'
...
---
_id: '3757'
abstract:
- lang: eng
text: A central problem in biology is determining how genes interact as parts of
functional networks. Creation and analysis of synthetic networks, composed of
well-characterized genetic elements, provide a framework for theoretical modeling.
Here, with the use of a combinatorial method, a library of networks with varying
connectivity was generated in Escherichia coli. These networks were composed of
genes encoding the transcriptional regulators Lacl, TetR, and lambda Cl, as well
as the corresponding promoters. They displayed phenotypic behaviors resembling
binary logical circuits, with two chemical “inputs” and a fluorescent protein
“output.” Within this simple system, diverse computational functions arose through
changes in network connectivity. Combinatorial synthesis provides an alternative
approach for studying biological networks, as well as an efficient method for
producing diverse phenotypes in vivo.
article_processing_charge: No
article_type: original
author:
- first_name: Calin C
full_name: Guet, Calin C
id: 47F8433E-F248-11E8-B48F-1D18A9856A87
last_name: Guet
orcid: 0000-0001-6220-2052
- first_name: Michael
full_name: Elowitz, Michael
last_name: Elowitz
- first_name: Weihong
full_name: Hsing, Weihong
last_name: Hsing
- first_name: Stanislas
full_name: Leibler, Stanislas
last_name: Leibler
citation:
ama: Guet CC, Elowitz M, Hsing W, Leibler S. Combinatorial synthesis of genetic
networks. Science. 2002;296(5572):1466-1470. doi:10.1126/science.1067407
apa: Guet, C. C., Elowitz, M., Hsing, W., & Leibler, S. (2002). Combinatorial
synthesis of genetic networks. Science. American Association for the Advancement
of Science. https://doi.org/10.1126/science.1067407
chicago: Guet, Calin C, Michael Elowitz, Weihong Hsing, and Stanislas Leibler. “Combinatorial
Synthesis of Genetic Networks.” Science. American Association for the Advancement
of Science, 2002. https://doi.org/10.1126/science.1067407.
ieee: C. C. Guet, M. Elowitz, W. Hsing, and S. Leibler, “Combinatorial synthesis
of genetic networks,” Science, vol. 296, no. 5572. American Association
for the Advancement of Science, pp. 1466–1470, 2002.
ista: Guet CC, Elowitz M, Hsing W, Leibler S. 2002. Combinatorial synthesis of genetic
networks. Science. 296(5572), 1466–1470.
mla: Guet, Calin C., et al. “Combinatorial Synthesis of Genetic Networks.” Science,
vol. 296, no. 5572, American Association for the Advancement of Science, 2002,
pp. 1466–70, doi:10.1126/science.1067407.
short: C.C. Guet, M. Elowitz, W. Hsing, S. Leibler, Science 296 (2002) 1466–1470.
date_created: 2018-12-11T12:05:00Z
date_published: 2002-05-24T00:00:00Z
date_updated: 2023-07-11T12:48:53Z
day: '24'
doi: 10.1126/science.1067407
extern: '1'
external_id:
pmid:
- '12029133'
intvolume: ' 296'
issue: '5572'
language:
- iso: eng
month: '05'
oa_version: None
page: 1466 - 1470
pmid: 1
publication: Science
publication_identifier:
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '2471'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Combinatorial synthesis of genetic networks
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 296
year: '2002'
...
---
_id: '9444'
abstract:
- lang: eng
text: Epigenetic silenced alleles of the Arabidopsis SUPERMANlocus (the clark kent
alleles) are associated with dense hypermethylation at noncanonical cytosines
(CpXpG and asymmetric sites, where X = A, T, C, or G). A genetic screen for suppressors
of a hypermethylated clark kent mutant identified nine loss-of-function alleles
of CHROMOMETHYLASE3(CMT3), a novel cytosine methyltransferase homolog. These cmt3
mutants display a wild-type morphology but exhibit decreased CpXpG methylation
of the SUP gene and of other sequences throughout the genome. They also show reactivated
expression of endogenous retrotransposon sequences. These results show that a
non-CpG DNA methyltransferase is responsible for maintaining epigenetic gene silencing.
article_processing_charge: No
article_type: original
author:
- first_name: A. M.
full_name: Lindroth, A. M.
last_name: Lindroth
- first_name: Xiaofeng
full_name: Cao, Xiaofeng
last_name: Cao
- first_name: James P.
full_name: Jackson, James P.
last_name: Jackson
- first_name: Daniel
full_name: Zilberman, Daniel
id: 6973db13-dd5f-11ea-814e-b3e5455e9ed1
last_name: Zilberman
orcid: 0000-0002-0123-8649
- first_name: Claire M.
full_name: McCallum, Claire M.
last_name: McCallum
- first_name: Steven
full_name: Henikoff, Steven
last_name: Henikoff
- first_name: Steven E.
full_name: Jacobsen, Steven E.
last_name: Jacobsen
citation:
ama: Lindroth AM, Cao X, Jackson JP, et al. Requirement of CHROMOMETHYLASE3 for
maintenance of CpXpG methylation. Science. 2001;292(5524):2077-2080. doi:10.1126/science.1059745
apa: Lindroth, A. M., Cao, X., Jackson, J. P., Zilberman, D., McCallum, C. M., Henikoff,
S., & Jacobsen, S. E. (2001). Requirement of CHROMOMETHYLASE3 for maintenance
of CpXpG methylation. Science. American Association for the Advancement
of Science. https://doi.org/10.1126/science.1059745
chicago: Lindroth, A. M., Xiaofeng Cao, James P. Jackson, Daniel Zilberman, Claire
M. McCallum, Steven Henikoff, and Steven E. Jacobsen. “Requirement of CHROMOMETHYLASE3
for Maintenance of CpXpG Methylation.” Science. American Association for
the Advancement of Science, 2001. https://doi.org/10.1126/science.1059745.
ieee: A. M. Lindroth et al., “Requirement of CHROMOMETHYLASE3 for maintenance
of CpXpG methylation,” Science, vol. 292, no. 5524. American Association
for the Advancement of Science, pp. 2077–2080, 2001.
ista: Lindroth AM, Cao X, Jackson JP, Zilberman D, McCallum CM, Henikoff S, Jacobsen
SE. 2001. Requirement of CHROMOMETHYLASE3 for maintenance of CpXpG methylation.
Science. 292(5524), 2077–2080.
mla: Lindroth, A. M., et al. “Requirement of CHROMOMETHYLASE3 for Maintenance of
CpXpG Methylation.” Science, vol. 292, no. 5524, American Association for
the Advancement of Science, 2001, pp. 2077–80, doi:10.1126/science.1059745.
short: A.M. Lindroth, X. Cao, J.P. Jackson, D. Zilberman, C.M. McCallum, S. Henikoff,
S.E. Jacobsen, Science 292 (2001) 2077–2080.
date_created: 2021-06-02T13:35:16Z
date_published: 2001-06-15T00:00:00Z
date_updated: 2021-12-14T08:40:32Z
day: '15'
department:
- _id: DaZi
doi: 10.1126/science.1059745
extern: '1'
external_id:
pmid:
- '11349138'
intvolume: ' 292'
issue: '5524'
keyword:
- Multidisciplinary
language:
- iso: eng
month: '06'
oa_version: None
page: 2077-2080
pmid: 1
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Requirement of CHROMOMETHYLASE3 for maintenance of CpXpG methylation
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 292
year: '2001'
...
---
_id: '3438'
abstract:
- lang: eng
text: As a discipline, phylogenetics is becoming transformed by a flood of molecular
data. These data allow broad questions to be asked about the history of life,
but also present difficult statistical and computational problems. Bayesian inference
of phylogeny brings a new perspective to a number of outstanding issues in evolutionary
biology, including the analysis of large phylogenetic trees and complex evolutionary
models and the detection of the footprint of natural selection in DNA sequences.
article_processing_charge: No
author:
- first_name: John
full_name: Huelsenbeck, John
last_name: Huelsenbeck
- first_name: Fredrik
full_name: Ronquist, Fredrik
last_name: Ronquist
- first_name: Rasmus
full_name: Nielsen, Rasmus
last_name: Nielsen
- first_name: Jonathan P
full_name: Bollback, Jonathan P
id: 2C6FA9CC-F248-11E8-B48F-1D18A9856A87
last_name: Bollback
orcid: 0000-0002-4624-4612
citation:
ama: Huelsenbeck J, Ronquist F, Nielsen R, Bollback JP. Bayesian inference of phylogeny
and its impact on evolutionary biology. Science. 2001;294(5550):2310-2314.
doi:10.1126/science.1065889
apa: Huelsenbeck, J., Ronquist, F., Nielsen, R., & Bollback, J. P. (2001). Bayesian
inference of phylogeny and its impact on evolutionary biology. Science.
American Association for the Advancement of Science. https://doi.org/10.1126/science.1065889
chicago: Huelsenbeck, John, Fredrik Ronquist, Rasmus Nielsen, and Jonathan P Bollback.
“Bayesian Inference of Phylogeny and Its Impact on Evolutionary Biology.” Science.
American Association for the Advancement of Science, 2001. https://doi.org/10.1126/science.1065889.
ieee: J. Huelsenbeck, F. Ronquist, R. Nielsen, and J. P. Bollback, “Bayesian inference
of phylogeny and its impact on evolutionary biology,” Science, vol. 294,
no. 5550. American Association for the Advancement of Science, pp. 2310–2314,
2001.
ista: Huelsenbeck J, Ronquist F, Nielsen R, Bollback JP. 2001. Bayesian inference
of phylogeny and its impact on evolutionary biology. Science. 294(5550), 2310–2314.
mla: Huelsenbeck, John, et al. “Bayesian Inference of Phylogeny and Its Impact on
Evolutionary Biology.” Science, vol. 294, no. 5550, American Association
for the Advancement of Science, 2001, pp. 2310–14, doi:10.1126/science.1065889.
short: J. Huelsenbeck, F. Ronquist, R. Nielsen, J.P. Bollback, Science 294 (2001)
2310–2314.
date_created: 2018-12-11T12:03:20Z
date_published: 2001-12-14T00:00:00Z
date_updated: 2023-05-15T14:10:13Z
day: '14'
doi: 10.1126/science.1065889
extern: '1'
external_id:
pmid:
- '11743192 '
intvolume: ' 294'
issue: '5550'
language:
- iso: eng
month: '12'
oa_version: None
page: 2310 - 2314
pmid: 1
publication: Science
publication_identifier:
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '2962'
quality_controlled: '1'
status: public
title: Bayesian inference of phylogeny and its impact on evolutionary biology
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 294
year: '2001'
...
---
_id: '2601'
abstract:
- lang: eng
text: Targeted deletion of metabotropic glutamate receptor-subtype 1 (mGluR1) gene
can cause defects in development and function in the cerebellum. We introduced
the mGluR1α transgene into mGluR1-null mutant [mGluR1 (-/-)] mice with a Purkinje
cell (PC)-specific promoter. mGluR1-rescue mice showed normal cerebellar long-term
depression and regression of multiple climbing fiber innervation, events significantly
impaired in mGluR1 (-/-) mice. The impaired motor coordination was rescued by
this transgene, in a dose-dependent manner. We propose that mGluR1 in PCs is a
key molecule for normal synapse formation, synaptic plasticity, and motor control
in the cerebellum.
article_processing_charge: No
article_type: original
author:
- first_name: Taeko
full_name: Ichise, Taeko
last_name: Ichise
- first_name: Masanobu
full_name: Kano, Masanobu
last_name: Kano
- first_name: Kouichi
full_name: Hashimoto, Kouichi
last_name: Hashimoto
- first_name: Dai
full_name: Yanagihara, Dai
last_name: Yanagihara
- first_name: Kazuki
full_name: Nakao, Kazuki
last_name: Nakao
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Motoya
full_name: Katsuki, Motoya
last_name: Katsuki
- first_name: Atsu
full_name: Aiba, Atsu
last_name: Aiba
citation:
ama: Ichise T, Kano M, Hashimoto K, et al. mGluR1 in cerebellar Purkinje cells essential
for long-term depression, synapse elimination, and motor coordination. Science.
2000;288(5472):1832-1835. doi:10.1126/science.288.5472.1832
apa: Ichise, T., Kano, M., Hashimoto, K., Yanagihara, D., Nakao, K., Shigemoto,
R., … Aiba, A. (2000). mGluR1 in cerebellar Purkinje cells essential for long-term
depression, synapse elimination, and motor coordination. Science. American
Association for the Advancement of Science. https://doi.org/10.1126/science.288.5472.1832
chicago: Ichise, Taeko, Masanobu Kano, Kouichi Hashimoto, Dai Yanagihara, Kazuki
Nakao, Ryuichi Shigemoto, Motoya Katsuki, and Atsu Aiba. “MGluR1 in Cerebellar
Purkinje Cells Essential for Long-Term Depression, Synapse Elimination, and Motor
Coordination.” Science. American Association for the Advancement of Science,
2000. https://doi.org/10.1126/science.288.5472.1832.
ieee: T. Ichise et al., “mGluR1 in cerebellar Purkinje cells essential for
long-term depression, synapse elimination, and motor coordination,” Science,
vol. 288, no. 5472. American Association for the Advancement of Science, pp. 1832–1835,
2000.
ista: Ichise T, Kano M, Hashimoto K, Yanagihara D, Nakao K, Shigemoto R, Katsuki
M, Aiba A. 2000. mGluR1 in cerebellar Purkinje cells essential for long-term depression,
synapse elimination, and motor coordination. Science. 288(5472), 1832–1835.
mla: Ichise, Taeko, et al. “MGluR1 in Cerebellar Purkinje Cells Essential for Long-Term
Depression, Synapse Elimination, and Motor Coordination.” Science, vol.
288, no. 5472, American Association for the Advancement of Science, 2000, pp.
1832–35, doi:10.1126/science.288.5472.1832.
short: T. Ichise, M. Kano, K. Hashimoto, D. Yanagihara, K. Nakao, R. Shigemoto,
M. Katsuki, A. Aiba, Science 288 (2000) 1832–1835.
date_created: 2018-12-11T11:58:36Z
date_published: 2000-06-09T00:00:00Z
date_updated: 2023-05-03T09:53:38Z
day: '09'
doi: 10.1126/science.288.5472.1832
extern: '1'
external_id:
pmid:
- '10846166 '
intvolume: ' 288'
issue: '5472'
language:
- iso: eng
month: '06'
oa_version: None
page: 1832 - 1835
pmid: 1
publication: Science
publication_identifier:
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '4297'
quality_controlled: '1'
scopus_import: '1'
status: public
title: mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse
elimination, and motor coordination
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 288
year: '2000'
...
---
_id: '3491'
abstract:
- lang: eng
text: Fast and reliable activation of inhibitory interneurons is critical for the
stability of cortical neuronal networks. Active conductances in dendrites may
facilitate interneuron activation, but direct experimental evidence was unavailable.
Patch-clamp recordings from dendrites of hippocampal oriens- alveus interneurons
revealed high densities of voltage-gated sodium and potassium ion channels. Simultaneous
recordings from dendrites and somata suggested that action potential initiation
occurs preferentially in the axon with long threshold stimuli, but can be shifted
to somatodendritic sites when brief stimuli are applied. After initiation, action
potentials propagate over the somatodendritic domain with constant amplitude,
high velocity, and reliability, even during high-frequency trains.
article_processing_charge: No
article_type: original
author:
- first_name: Marco
full_name: Martina, Marco
last_name: Martina
- first_name: Imre
full_name: Vida, Imre
last_name: Vida
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Martina M, Vida I, Jonas PM. Distal initiation and active propagation of action
potentials in interneuron dendrites. Science. 2000;287(5451):295-300. doi:10.1126/science.287.5451.295
apa: Martina, M., Vida, I., & Jonas, P. M. (2000). Distal initiation and active
propagation of action potentials in interneuron dendrites. Science. American
Association for the Advancement of Science. https://doi.org/10.1126/science.287.5451.295
chicago: Martina, Marco, Imre Vida, and Peter M Jonas. “Distal Initiation and Active
Propagation of Action Potentials in Interneuron Dendrites.” Science. American
Association for the Advancement of Science, 2000. https://doi.org/10.1126/science.287.5451.295.
ieee: M. Martina, I. Vida, and P. M. Jonas, “Distal initiation and active propagation
of action potentials in interneuron dendrites,” Science, vol. 287, no.
5451. American Association for the Advancement of Science, pp. 295–300, 2000.
ista: Martina M, Vida I, Jonas PM. 2000. Distal initiation and active propagation
of action potentials in interneuron dendrites. Science. 287(5451), 295–300.
mla: Martina, Marco, et al. “Distal Initiation and Active Propagation of Action
Potentials in Interneuron Dendrites.” Science, vol. 287, no. 5451, American
Association for the Advancement of Science, 2000, pp. 295–300, doi:10.1126/science.287.5451.295.
short: M. Martina, I. Vida, P.M. Jonas, Science 287 (2000) 295–300.
date_created: 2018-12-11T12:03:36Z
date_published: 2000-01-14T00:00:00Z
date_updated: 2023-05-03T07:55:32Z
day: '14'
doi: 10.1126/science.287.5451.295
extern: '1'
external_id:
pmid:
- '10634782'
intvolume: ' 287'
issue: '5451'
language:
- iso: eng
month: '01'
oa_version: None
page: 295 - 300
pmid: 1
publication: Science
publication_identifier:
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '2896'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Distal initiation and active propagation of action potentials in interneuron
dendrites
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 287
year: '2000'
...
---
_id: '3487'
abstract:
- lang: eng
text: It is widely accepted that individual neurons in the central nervous system
release only a single fast transmitter. The possibility of corelease of fast neurotransmitters
was examined by making paired recordings from synaptically connected neurons in
spinal cord slices. Unitary inhibitory postsynaptic currents generated at interneuron-motoneuron
synapses consisted of a strychnine-sensitive, glycine receptor-mediated component
and a bicuculline-sensitive, γ-aminobutyric acid (GABA)(A) receptor-mediated component.
These results indicate that spinal interneurons release both glycine and GABA
to activate functionally distinct receptors in their postsynaptic target cells.
A subset of miniature synaptic currents also showed both components, consistent
with corelease from individual synaptic vesicles.
acknowledgement: "See comment by Nicoll RA, Malenka RC (1998) Science 281:360-361\r\n"
article_processing_charge: No
article_type: original
author:
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Joseph
full_name: Bischofberger, Joseph
last_name: Bischofberger
- first_name: Jürgen
full_name: Sandkühler, Jürgen
last_name: Sandkühler
citation:
ama: Jonas PM, Bischofberger J, Sandkühler J. Corelease of two fast neurotransmitters
at a central synapse. Science. 1998;281(5375):419-424. doi:10.1126/science.281.5375.419
apa: Jonas, P. M., Bischofberger, J., & Sandkühler, J. (1998). Corelease of
two fast neurotransmitters at a central synapse. Science. American Association
for the Advancement of Science. https://doi.org/10.1126/science.281.5375.419
chicago: Jonas, Peter M, Joseph Bischofberger, and Jürgen Sandkühler. “Corelease
of Two Fast Neurotransmitters at a Central Synapse.” Science. American
Association for the Advancement of Science, 1998. https://doi.org/10.1126/science.281.5375.419.
ieee: P. M. Jonas, J. Bischofberger, and J. Sandkühler, “Corelease of two fast neurotransmitters
at a central synapse,” Science, vol. 281, no. 5375. American Association
for the Advancement of Science, pp. 419–424, 1998.
ista: Jonas PM, Bischofberger J, Sandkühler J. 1998. Corelease of two fast neurotransmitters
at a central synapse. Science. 281(5375), 419–424.
mla: Jonas, Peter M., et al. “Corelease of Two Fast Neurotransmitters at a Central
Synapse.” Science, vol. 281, no. 5375, American Association for the Advancement
of Science, 1998, pp. 419–24, doi:10.1126/science.281.5375.419.
short: P.M. Jonas, J. Bischofberger, J. Sandkühler, Science 281 (1998) 419–424.
date_created: 2018-12-11T12:03:35Z
date_published: 1998-07-17T00:00:00Z
date_updated: 2022-08-29T14:52:38Z
day: '17'
doi: 10.1126/science.281.5375.419
extern: '1'
external_id:
pmid:
- '9665886 '
intvolume: ' 281'
issue: '5375'
language:
- iso: eng
month: '07'
oa_version: None
page: 419 - 424
pmid: 1
publication: Science
publication_identifier:
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '2900'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Corelease of two fast neurotransmitters at a central synapse
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 281
year: '1998'
...
---
_id: '4281'
abstract:
- lang: eng
text: 'Most higher organisms reproduce sexually, despite the automatic reproductive
advantage experienced by asexual variants. This implies the operation of selective
forces that confer an advantage to sexuality and genetic recombination, at either
the population or individual level. The effect of sex and recombination in breaking
down negative correlations between favorable variants at different genetic loci,
which increases the efficiency of natural selection, is likely to be a major factor
favoring their evolution and maintenance. Various processes that can cause such
an effect have been studied theoretically. It has, however, so far proved hard
to discriminate among them empirically. '
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Brian
full_name: Charlesworth, Brian
last_name: Charlesworth
citation:
ama: Barton NH, Charlesworth B. Why sex and recombination? Science. 1998;281(5385):1986-1990.
doi:10.1126/science.281.5385.1986
apa: Barton, N. H., & Charlesworth, B. (1998). Why sex and recombination? Science.
American Association for the Advancement of Science. https://doi.org/10.1126/science.281.5385.1986
chicago: Barton, Nicholas H, and Brian Charlesworth. “Why Sex and Recombination?”
Science. American Association for the Advancement of Science, 1998. https://doi.org/10.1126/science.281.5385.1986.
ieee: N. H. Barton and B. Charlesworth, “Why sex and recombination?,” Science,
vol. 281, no. 5385. American Association for the Advancement of Science, pp. 1986–1990,
1998.
ista: Barton NH, Charlesworth B. 1998. Why sex and recombination? Science. 281(5385),
1986–1990.
mla: Barton, Nicholas H., and Brian Charlesworth. “Why Sex and Recombination?” Science,
vol. 281, no. 5385, American Association for the Advancement of Science, 1998,
pp. 1986–90, doi:10.1126/science.281.5385.1986.
short: N.H. Barton, B. Charlesworth, Science 281 (1998) 1986–1990.
date_created: 2018-12-11T12:08:01Z
date_published: 1998-09-25T00:00:00Z
date_updated: 2022-08-25T11:53:29Z
day: '25'
doi: 10.1126/science.281.5385.1986
extern: '1'
external_id:
pmid:
- '9748151'
intvolume: ' 281'
issue: '5385'
language:
- iso: eng
month: '09'
oa_version: None
page: 1986 - 1990
pmid: 1
publication: Science
publication_identifier:
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '1804'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Why sex and recombination?
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 281
year: '1998'
...
---
_id: '2571'
abstract:
- lang: eng
text: Subtype 2 of the metabotropic glutamate receptor (mGluR2) is expressed in
the presynaptic elements of hippocampal mossy fiber-CA3 synapses. Knockout mice
deficient in mGluR2 showed no histological changes and no alterations in basal
synaptic transmission, paired-pulse facilitation, or tetanus-induced long-term
potentiation (LTP) at the mossy fiber-CA3 synapses. Long-term depression (LTD)
induced by low-frequency stimulation, however, was almost fully abolished. The
mutant mice performed normally in water maze learning tasks. Thus, the presynaptic
mGluR2 is essential for inducing LTD at the mossy fiber-CA3 synapses, but this
hippocampal LTD does not seem to be required for spatial learning.
article_processing_charge: No
article_type: original
author:
- first_name: Mineto
full_name: Yokoi, Mineto
last_name: Yokoi
- first_name: Kazuto
full_name: Kobayashi, Kazuto
last_name: Kobayashi
- first_name: Toshiya
full_name: Manabe, Toshiya
last_name: Manabe
- first_name: Tomoyuki
full_name: Takahashi, Tomoyuki
last_name: Takahashi
- first_name: Isako
full_name: Sakaguchi, Isako
last_name: Sakaguchi
- first_name: Goro
full_name: Katsuura, Goro
last_name: Katsuura
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Sakashi
full_name: Nomura, Sakashi
last_name: Nomura
- first_name: Kenji
full_name: Nakamura, Kenji
last_name: Nakamura
- first_name: Kazuki
full_name: Nakao, Kazuki
last_name: Nakao
- first_name: Motoya
full_name: Katsuki, Motoya
last_name: Katsuki
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
citation:
ama: Yokoi M, Kobayashi K, Manabe T, et al. Impairment of hippocampal mossy fiber
LTD in mice lacking mGluR2. Science. 1996;273:645-647. doi:10.1126/science.273.5275.645
apa: Yokoi, M., Kobayashi, K., Manabe, T., Takahashi, T., Sakaguchi, I., Katsuura,
G., … Nakanishi, S. (1996). Impairment of hippocampal mossy fiber LTD in mice
lacking mGluR2. Science. American Association for the Advancement of Science.
https://doi.org/10.1126/science.273.5275.645
chicago: Yokoi, Mineto, Kazuto Kobayashi, Toshiya Manabe, Tomoyuki Takahashi, Isako
Sakaguchi, Goro Katsuura, Ryuichi Shigemoto, et al. “Impairment of Hippocampal
Mossy Fiber LTD in Mice Lacking MGluR2.” Science. American Association
for the Advancement of Science, 1996. https://doi.org/10.1126/science.273.5275.645.
ieee: M. Yokoi et al., “Impairment of hippocampal mossy fiber LTD in mice
lacking mGluR2,” Science, vol. 273. American Association for the Advancement
of Science, pp. 645–647, 1996.
ista: Yokoi M, Kobayashi K, Manabe T, Takahashi T, Sakaguchi I, Katsuura G, Shigemoto
R, Ohishi H, Nomura S, Nakamura K, Nakao K, Katsuki M, Nakanishi S. 1996. Impairment
of hippocampal mossy fiber LTD in mice lacking mGluR2. Science. 273, 645–647.
mla: Yokoi, Mineto, et al. “Impairment of Hippocampal Mossy Fiber LTD in Mice Lacking
MGluR2.” Science, vol. 273, American Association for the Advancement of
Science, 1996, pp. 645–47, doi:10.1126/science.273.5275.645.
short: M. Yokoi, K. Kobayashi, T. Manabe, T. Takahashi, I. Sakaguchi, G. Katsuura,
R. Shigemoto, H. Ohishi, S. Nomura, K. Nakamura, K. Nakao, M. Katsuki, S. Nakanishi,
Science 273 (1996) 645–647.
date_created: 2018-12-11T11:58:27Z
date_published: 1996-08-02T00:00:00Z
date_updated: 2022-08-11T13:53:55Z
day: '02'
doi: 10.1126/science.273.5275.645
extern: '1'
external_id:
pmid:
- '8662555 '
intvolume: ' 273'
language:
- iso: eng
month: '08'
oa_version: None
page: 645 - 647
pmid: 1
publication: Science
publication_identifier:
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '4327'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 273
year: '1996'
...
---
_id: '3469'
abstract:
- lang: eng
text: Glutamate-operated ion channels (GluR channels) of the L-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic
acid (AMPA)-kainate subtype are found in both neurons and glial cells of the central
nervous system. These channels are assembled from the GluR-A, -B, -C, and -D subunits;
channels containing a GluR-B subunit show an outwardly rectifying current-voltage
relation and low calcium permeability, whereas channels lacking the GluR-B subunit
are characterized by a doubly rectifying current-voltage relation and high calcium
permeability. Most cell types in the central nervous system coexpress several
subunits, including GluR-B. However, Bergmann glia in rat cerebellum do not express
GluR-B subunit genes. In a subset of cultured cerebellar glial cells, likely derived
from Bergmann glial cells. GluR channels exhibit doubly rectifying current-voltage
relations and high calcium permeability, whereas GluR channels of cerebellar neurons
have low calcium permeability. Thus, differential expression of the GluR-B subunit
gene in neurons and glia is one mechanism by which functional properties of native
GluR channels are regulated.
article_processing_charge: No
article_type: original
author:
- first_name: Nail
full_name: Burnashev, Nail
last_name: Burnashev
- first_name: Alla
full_name: Khodorova, Alla
last_name: Khodorova
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: P.
full_name: Helm, P.
last_name: Helm
- first_name: William
full_name: Wisden, William
last_name: Wisden
- first_name: Hannah
full_name: Monyer, Hannah
last_name: Monyer
- first_name: Peter
full_name: Seeburg, Peter
last_name: Seeburg
- first_name: Bert
full_name: Sakmann, Bert
last_name: Sakmann
citation:
ama: Burnashev N, Khodorova A, Jonas PM, et al. Calcium-permeable AMPA-kainate receptors
in fusiform cerebellar glial cells. Science. 1992;256(5063):1566-1570.
doi:10.1126/science.1317970
apa: Burnashev, N., Khodorova, A., Jonas, P. M., Helm, P., Wisden, W., Monyer, H.,
… Sakmann, B. (1992). Calcium-permeable AMPA-kainate receptors in fusiform cerebellar
glial cells. Science. American Association for the Advancement of Science.
https://doi.org/10.1126/science.1317970
chicago: Burnashev, Nail, Alla Khodorova, Peter M Jonas, P. Helm, William Wisden,
Hannah Monyer, Peter Seeburg, and Bert Sakmann. “Calcium-Permeable AMPA-Kainate
Receptors in Fusiform Cerebellar Glial Cells.” Science. American Association
for the Advancement of Science, 1992. https://doi.org/10.1126/science.1317970.
ieee: N. Burnashev et al., “Calcium-permeable AMPA-kainate receptors in fusiform
cerebellar glial cells.,” Science, vol. 256, no. 5063. American Association
for the Advancement of Science, pp. 1566–1570, 1992.
ista: Burnashev N, Khodorova A, Jonas PM, Helm P, Wisden W, Monyer H, Seeburg P,
Sakmann B. 1992. Calcium-permeable AMPA-kainate receptors in fusiform cerebellar
glial cells. Science. 256(5063), 1566–1570.
mla: Burnashev, Nail, et al. “Calcium-Permeable AMPA-Kainate Receptors in Fusiform
Cerebellar Glial Cells.” Science, vol. 256, no. 5063, American Association
for the Advancement of Science, 1992, pp. 1566–70, doi:10.1126/science.1317970.
short: N. Burnashev, A. Khodorova, P.M. Jonas, P. Helm, W. Wisden, H. Monyer, P.
Seeburg, B. Sakmann, Science 256 (1992) 1566–1570.
date_created: 2018-12-11T12:03:30Z
date_published: 1992-06-12T00:00:00Z
date_updated: 2022-03-16T13:24:52Z
day: '12'
doi: 10.1126/science.1317970
extern: '1'
external_id:
pmid:
- '1317970'
intvolume: ' 256'
issue: '5063'
language:
- iso: eng
main_file_link:
- url: https://www.science.org/doi/10.1126/science.1317970
month: '06'
oa_version: None
page: 1566 - 1570
pmid: 1
publication: Science
publication_identifier:
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '2918'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Calcium-permeable AMPA-kainate receptors in fusiform cerebellar glial cells.
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 256
year: '1992'
...