[{"department":[{"_id":"JoFi"}],"degree_awarded":"PhD","date_created":"2023-05-31T11:39:24Z","date_published":"2023-05-18T00:00:00Z","month":"05","language":[{"iso":"eng"}],"publisher":"American Association for the Advancement of Science","page":"718-721","type":"dissertation","day":"18","status":"public","intvolume":"       380","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2301.03315","open_access":"1"}],"isi":1,"related_material":{"record":[{"status":"public","id":"13122","relation":"research_data"}],"link":[{"relation":"press_release","description":"News on ISTA Website","url":"https://ista.ac.at/en/news/wiring-up-quantum-circuits-with-light/"}]},"ec_funded":1,"year":"2023","doi":"10.1126/science.adg3812","external_id":{"arxiv":["2301.03315"],"isi":["000996515200004"]},"title":"Entangling microwaves with light","date_updated":"2025-07-15T09:17:40Z","oa":1,"volume":380,"article_processing_charge":"No","arxiv":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","acknowledgement":"This work was supported by the European Research Council (grant no. 758053, ERC StG QUNNECT) and the European Union’s Horizon 2020 Research and Innovation Program (grant no. 899354, FETopen SuperQuLAN). L.Q. acknowledges generous support from the ISTFELLOW program. W.H. is the recipient of an ISTplus postdoctoral fellowship with funding from the European Union’s Horizon 2020 Research and Innovation Program (Marie Sklodowska-Curie grant no. 754411). G.A. is the recipient of a DOC fellowship of the Austrian Academy of Sciences at IST Austria. J.M.F. acknowledges support from the Austrian Science Fund (FWF) through BeyondC (grant no. F7105) and the European Union’s Horizon 2020 Research and Innovation Program (grant no. 862644, FETopen QUARTET).","project":[{"call_identifier":"H2020","_id":"26336814-B435-11E9-9278-68D0E5697425","name":"A Fiber Optic Transceiver for Superconducting Qubits","grant_number":"758053"},{"grant_number":"899354","call_identifier":"H2020","_id":"9B868D20-BA93-11EA-9121-9846C619BF3A","name":"Quantum Local Area Networks with Superconducting Qubits"},{"grant_number":"754411","call_identifier":"H2020","_id":"260C2330-B435-11E9-9278-68D0E5697425","name":"ISTplus - Postdoctoral Fellowships"},{"grant_number":"F07105","call_identifier":"FWF","name":"Integrating superconducting quantum circuits","_id":"26927A52-B435-11E9-9278-68D0E5697425"},{"grant_number":"862644","_id":"237CBA6C-32DE-11EA-91FC-C7463DDC885E","name":"Quantum readout techniques and technologies","call_identifier":"H2020"},{"_id":"2671EB66-B435-11E9-9278-68D0E5697425","name":"Coherent on-chip conversion of superconducting qubit signals from microwaves to optical frequencies"}],"oa_version":"Preprint","_id":"13106","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"publication_status":"published","citation":{"chicago":"Sahu, Rishabh, Liu Qiu, William J Hease, Georg M Arnold, Y. Minoguchi, P. Rabl, and Johannes M Fink. “Entangling Microwaves with Light.” American Association for the Advancement of Science, 2023. <a href=\"https://doi.org/10.1126/science.adg3812\">https://doi.org/10.1126/science.adg3812</a>.","apa":"Sahu, R., Qiu, L., Hease, W. J., Arnold, G. M., Minoguchi, Y., Rabl, P., &#38; Fink, J. M. (2023). <i>Entangling microwaves with light</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.adg3812\">https://doi.org/10.1126/science.adg3812</a>","ieee":"R. Sahu <i>et al.</i>, “Entangling microwaves with light,” American Association for the Advancement of Science, 2023.","short":"R. Sahu, L. Qiu, W.J. Hease, G.M. Arnold, Y. Minoguchi, P. Rabl, J.M. Fink, Entangling Microwaves with Light, American Association for the Advancement of Science, 2023.","ista":"Sahu R, Qiu L, Hease WJ, Arnold GM, Minoguchi Y, Rabl P, Fink JM. 2023. Entangling microwaves with light. American Association for the Advancement of Science.","mla":"Sahu, Rishabh, et al. <i>Entangling Microwaves with Light</i>. Vol. 380, American Association for the Advancement of Science, 2023, pp. 718–21, doi:<a href=\"https://doi.org/10.1126/science.adg3812\">10.1126/science.adg3812</a>.","ama":"Sahu R, Qiu L, Hease WJ, et al. Entangling microwaves with light. 2023;380:718-721. doi:<a href=\"https://doi.org/10.1126/science.adg3812\">10.1126/science.adg3812</a>"},"keyword":["Multidisciplinary"],"author":[{"id":"47D26E34-F248-11E8-B48F-1D18A9856A87","first_name":"Rishabh","orcid":"0000-0001-6264-2162","full_name":"Sahu, Rishabh","last_name":"Sahu"},{"id":"45e99c0d-1eb1-11eb-9b96-ed8ab2983cac","orcid":"0000-0003-4345-4267","last_name":"Qiu","full_name":"Qiu, Liu","first_name":"Liu"},{"id":"29705398-F248-11E8-B48F-1D18A9856A87","first_name":"William J","last_name":"Hease","full_name":"Hease, William J","orcid":"0000-0001-9868-2166"},{"first_name":"Georg M","full_name":"Arnold, Georg M","last_name":"Arnold","orcid":"0000-0003-1397-7876","id":"3770C838-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Y.","last_name":"Minoguchi","full_name":"Minoguchi, Y."},{"last_name":"Rabl","full_name":"Rabl, P.","first_name":"P."},{"first_name":"Johannes M","orcid":"0000-0001-8112-028X","last_name":"Fink","full_name":"Fink, Johannes M","id":"4B591CBA-F248-11E8-B48F-1D18A9856A87"}],"abstract":[{"lang":"eng","text":"Quantum entanglement is a key resource in currently developed quantum technologies. Sharing this fragile property between superconducting microwave circuits and optical or atomic systems would enable new functionalities, but this has been hindered by an energy scale mismatch of >104 and the resulting mutually imposed loss and noise. In this work, we created and verified entanglement between microwave and optical fields in a millikelvin environment. Using an optically pulsed superconducting electro-optical device, we show entanglement between propagating microwave and optical fields in the continuous variable domain. This achievement not only paves the way for entanglement between superconducting circuits and telecom wavelength light, but also has wide-ranging implications for hybrid quantum networks in the context of modularization, scaling, sensing, and cross-platform verification."}]},{"article_processing_charge":"No","date_updated":"2023-11-07T12:42:09Z","volume":381,"extern":"1","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"pmid":1,"_id":"14281","quality_controlled":"1","oa_version":"None","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"ama":"Praetorius FM, Leung PJY, Tessmer MH, et al. Design of stimulus-responsive two-state hinge proteins. <i>Science</i>. 2023;381(6659):754-760. doi:<a href=\"https://doi.org/10.1126/science.adg7731\">10.1126/science.adg7731</a>","mla":"Praetorius, Florian M., et al. “Design of Stimulus-Responsive Two-State Hinge Proteins.” <i>Science</i>, vol. 381, no. 6659, American Association for the Advancement of Science, 2023, pp. 754–60, doi:<a href=\"https://doi.org/10.1126/science.adg7731\">10.1126/science.adg7731</a>.","short":"F.M. Praetorius, P.J.Y. Leung, M.H. Tessmer, A. Broerman, C. Demakis, A.F. Dishman, A. Pillai, A. Idris, D. Juergens, J. Dauparas, X. Li, P.M. Levine, M. Lamb, R.K. Ballard, S.R. Gerben, H. Nguyen, A. Kang, B. Sankaran, A.K. Bera, B.F. Volkman, J. Nivala, S. Stoll, D. Baker, Science 381 (2023) 754–760.","ista":"Praetorius FM, Leung PJY, Tessmer MH, Broerman A, Demakis C, Dishman AF, Pillai A, Idris A, Juergens D, Dauparas J, Li X, Levine PM, Lamb M, Ballard RK, Gerben SR, Nguyen H, Kang A, Sankaran B, Bera AK, Volkman BF, Nivala J, Stoll S, Baker D. 2023. Design of stimulus-responsive two-state hinge proteins. Science. 381(6659), 754–760.","ieee":"F. M. Praetorius <i>et al.</i>, “Design of stimulus-responsive two-state hinge proteins,” <i>Science</i>, vol. 381, no. 6659. American Association for the Advancement of Science, pp. 754–760, 2023.","apa":"Praetorius, F. M., Leung, P. J. Y., Tessmer, M. H., Broerman, A., Demakis, C., Dishman, A. F., … Baker, D. (2023). Design of stimulus-responsive two-state hinge proteins. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.adg7731\">https://doi.org/10.1126/science.adg7731</a>","chicago":"Praetorius, Florian M, Philip J. Y. Leung, Maxx H. Tessmer, Adam Broerman, Cullen Demakis, Acacia F. Dishman, Arvind Pillai, et al. “Design of Stimulus-Responsive Two-State Hinge Proteins.” <i>Science</i>. American Association for the Advancement of Science, 2023. <a href=\"https://doi.org/10.1126/science.adg7731\">https://doi.org/10.1126/science.adg7731</a>."},"publication_status":"published","abstract":[{"lang":"eng","text":"In nature, proteins that switch between two conformations in response to environmental stimuli structurally transduce biochemical information in a manner analogous to how transistors control information flow in computing devices. Designing proteins with two distinct but fully structured conformations is a challenge for protein design as it requires sculpting an energy landscape with two distinct minima. Here we describe the design of “hinge” proteins that populate one designed state in the absence of ligand and a second designed state in the presence of ligand. X-ray crystallography, electron microscopy, double electron-electron resonance spectroscopy, and binding measurements demonstrate that despite the significant structural differences the two states are designed with atomic level accuracy and that the conformational and binding equilibria are closely coupled."}],"author":[{"last_name":"Praetorius","full_name":"Praetorius, Florian M","first_name":"Florian M","id":"dfec9381-4341-11ee-8fd8-faa02bba7d62"},{"first_name":"Philip J. Y.","full_name":"Leung, Philip J. Y.","last_name":"Leung"},{"first_name":"Maxx H.","full_name":"Tessmer, Maxx H.","last_name":"Tessmer"},{"full_name":"Broerman, Adam","last_name":"Broerman","first_name":"Adam"},{"full_name":"Demakis, Cullen","last_name":"Demakis","first_name":"Cullen"},{"full_name":"Dishman, Acacia F.","last_name":"Dishman","first_name":"Acacia F."},{"first_name":"Arvind","last_name":"Pillai","full_name":"Pillai, Arvind"},{"first_name":"Abbas","full_name":"Idris, Abbas","last_name":"Idris"},{"full_name":"Juergens, David","last_name":"Juergens","first_name":"David"},{"first_name":"Justas","last_name":"Dauparas","full_name":"Dauparas, Justas"},{"full_name":"Li, Xinting","last_name":"Li","first_name":"Xinting"},{"first_name":"Paul M.","full_name":"Levine, Paul M.","last_name":"Levine"},{"first_name":"Mila","full_name":"Lamb, Mila","last_name":"Lamb"},{"first_name":"Ryanne K.","last_name":"Ballard","full_name":"Ballard, Ryanne K."},{"first_name":"Stacey R.","full_name":"Gerben, Stacey R.","last_name":"Gerben"},{"full_name":"Nguyen, Hannah","last_name":"Nguyen","first_name":"Hannah"},{"first_name":"Alex","last_name":"Kang","full_name":"Kang, Alex"},{"first_name":"Banumathi","full_name":"Sankaran, Banumathi","last_name":"Sankaran"},{"first_name":"Asim K.","full_name":"Bera, Asim K.","last_name":"Bera"},{"last_name":"Volkman","full_name":"Volkman, Brian F.","first_name":"Brian F."},{"last_name":"Nivala","full_name":"Nivala, Jeff","first_name":"Jeff"},{"last_name":"Stoll","full_name":"Stoll, Stefan","first_name":"Stefan"},{"first_name":"David","last_name":"Baker","full_name":"Baker, David"}],"year":"2023","doi":"10.1126/science.adg7731","title":"Design of stimulus-responsive two-state hinge proteins","external_id":{"pmid":["37590357"]},"publication":"Science","issue":"6659","page":"754-760","day":"17","type":"journal_article","intvolume":"       381","status":"public","date_created":"2023-09-06T12:04:23Z","month":"08","article_type":"original","date_published":"2023-08-17T00:00:00Z","scopus_import":"1","publisher":"American Association for the Advancement of Science","language":[{"iso":"eng"}]},{"language":[{"iso":"eng"}],"publisher":"American Association for the Advancement of Science","article_type":"original","date_published":"2022-04-22T00:00:00Z","month":"04","date_created":"2022-02-01T11:23:18Z","department":[{"_id":"DaSi"}],"status":"public","intvolume":"       376","type":"journal_article","day":"22","page":"394-396","publication":"Science","issue":"6591","title":"Cell division in tissues enables macrophage infiltration","external_id":{"pmid":["35446632"],"isi":["000788553700039"]},"doi":"10.1126/science.abj0425","year":"2022","acknowledged_ssus":[{"_id":"Bio"}],"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1101/2021.04.19.438995"}],"isi":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)"},"author":[{"first_name":"Maria","orcid":"0000-0003-1522-3162","full_name":"Akhmanova, Maria","last_name":"Akhmanova","id":"3425EC26-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Shamsi","orcid":"0000-0001-6981-6938","full_name":"Emtenani, Shamsi","last_name":"Emtenani","id":"49D32318-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Krueger","full_name":"Krueger, Daniel","first_name":"Daniel"},{"first_name":"Attila","last_name":"György","full_name":"György, Attila","orcid":"0000-0002-1819-198X","id":"3BCEDBE0-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Pereira Guarda","full_name":"Pereira Guarda, Mariana","first_name":"Mariana","id":"6de81d9d-e2f2-11eb-945a-af8bc2a60b26"},{"last_name":"Vlasov","full_name":"Vlasov, Mikhail","first_name":"Mikhail"},{"first_name":"Fedor","last_name":"Vlasov","full_name":"Vlasov, Fedor"},{"first_name":"Andrei","last_name":"Akopian","full_name":"Akopian, Andrei"},{"id":"2F064CFE-F248-11E8-B48F-1D18A9856A87","first_name":"Aparna","full_name":"Ratheesh, Aparna","last_name":"Ratheesh"},{"full_name":"De Renzis, Stefano","last_name":"De Renzis","first_name":"Stefano"},{"id":"3D224B9E-F248-11E8-B48F-1D18A9856A87","first_name":"Daria E","last_name":"Siekhaus","full_name":"Siekhaus, Daria E","orcid":"0000-0001-8323-8353"}],"abstract":[{"lang":"eng","text":"Cells migrate through crowded microenvironments within tissues during normal development, immune response, and cancer metastasis. Although migration through pores and tracks in the extracellular matrix (ECM) has been well studied, little is known about cellular traversal into confining cell-dense tissues. We find that embryonic tissue invasion by Drosophila macrophages requires division of an epithelial ectodermal cell at the site of entry. Dividing ectodermal cells disassemble ECM attachment formed by integrin-mediated focal adhesions next to mesodermal cells, allowing macrophages to move their nuclei ahead and invade between two immediately adjacent tissues. Invasion efficiency depends on division frequency, but reduction of adhesion strength allows macrophage entry independently of division. This work demonstrates that tissue dynamics can regulate cellular infiltration."}],"citation":{"ista":"Akhmanova M, Emtenani S, Krueger D, György A, Pereira Guarda M, Vlasov M, Vlasov F, Akopian A, Ratheesh A, De Renzis S, Siekhaus DE. 2022. Cell division in tissues enables macrophage infiltration. Science. 376(6591), 394–396.","short":"M. Akhmanova, S. Emtenani, D. Krueger, A. György, M. Pereira Guarda, M. Vlasov, F. Vlasov, A. Akopian, A. Ratheesh, S. De Renzis, D.E. Siekhaus, Science 376 (2022) 394–396.","mla":"Akhmanova, Maria, et al. “Cell Division in Tissues Enables Macrophage Infiltration.” <i>Science</i>, vol. 376, no. 6591, American Association for the Advancement of Science, 2022, pp. 394–96, doi:<a href=\"https://doi.org/10.1126/science.abj0425\">10.1126/science.abj0425</a>.","ama":"Akhmanova M, Emtenani S, Krueger D, et al. Cell division in tissues enables macrophage infiltration. <i>Science</i>. 2022;376(6591):394-396. doi:<a href=\"https://doi.org/10.1126/science.abj0425\">10.1126/science.abj0425</a>","chicago":"Akhmanova, Maria, Shamsi Emtenani, Daniel Krueger, Attila György, Mariana Pereira Guarda, Mikhail Vlasov, Fedor Vlasov, et al. “Cell Division in Tissues Enables Macrophage Infiltration.” <i>Science</i>. American Association for the Advancement of Science, 2022. <a href=\"https://doi.org/10.1126/science.abj0425\">https://doi.org/10.1126/science.abj0425</a>.","ieee":"M. Akhmanova <i>et al.</i>, “Cell division in tissues enables macrophage infiltration,” <i>Science</i>, vol. 376, no. 6591. American Association for the Advancement of Science, pp. 394–396, 2022.","apa":"Akhmanova, M., Emtenani, S., Krueger, D., György, A., Pereira Guarda, M., Vlasov, M., … Siekhaus, D. E. (2022). Cell division in tissues enables macrophage infiltration. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.abj0425\">https://doi.org/10.1126/science.abj0425</a>"},"publication_status":"published","quality_controlled":"1","project":[{"grant_number":"M02379","name":"Modeling epithelial tissue mechanics during cell invasion","_id":"264CBBAC-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"}],"oa_version":"Preprint","acknowledgement":"We thank J. Friml, C. Guet, T. Hurd, M. Fendrych and members of the laboratory for comments on the manuscript; the Bioimaging Facility of IST Austria for excellent support and T. Lecuit, E. Hafen, R. Levayer and A. Martin for fly strains. This work was supported by a grant from the Austrian Science Fund FWF: Lise Meitner Fellowship M2379-B28 to M.A and D.S., and internal funding from IST Austria to D.S. and EMBL to S.D.R.","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publication_identifier":{"issn":["0036-8075"]},"_id":"10713","pmid":1,"article_processing_charge":"No","oa":1,"volume":376,"date_updated":"2023-08-02T14:06:15Z"},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","quality_controlled":"1","oa_version":"None","pmid":1,"_id":"14282","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"extern":"1","date_updated":"2023-11-07T12:39:56Z","volume":375,"article_processing_charge":"No","author":[{"first_name":"Danny D.","full_name":"Sahtoe, Danny D.","last_name":"Sahtoe"},{"last_name":"Praetorius","full_name":"Praetorius, Florian M","first_name":"Florian M","id":"dfec9381-4341-11ee-8fd8-faa02bba7d62"},{"first_name":"Alexis","last_name":"Courbet","full_name":"Courbet, Alexis"},{"last_name":"Hsia","full_name":"Hsia, Yang","first_name":"Yang"},{"first_name":"Basile I. M.","full_name":"Wicky, Basile I. M.","last_name":"Wicky"},{"last_name":"Edman","full_name":"Edman, Natasha I.","first_name":"Natasha I."},{"first_name":"Lauren M.","last_name":"Miller","full_name":"Miller, Lauren M."},{"first_name":"Bart J. R.","full_name":"Timmermans, Bart J. R.","last_name":"Timmermans"},{"last_name":"Decarreau","full_name":"Decarreau, Justin","first_name":"Justin"},{"full_name":"Morris, Hana M.","last_name":"Morris","first_name":"Hana M."},{"last_name":"Kang","full_name":"Kang, Alex","first_name":"Alex"},{"full_name":"Bera, Asim K.","last_name":"Bera","first_name":"Asim K."},{"last_name":"Baker","full_name":"Baker, David","first_name":"David"}],"abstract":[{"lang":"eng","text":"Asymmetric multiprotein complexes that undergo subunit exchange play central roles in biology but present a challenge for design because the components must not only contain interfaces that enable reversible association but also be stable and well behaved in isolation. We use implicit negative design to generate β sheet–mediated heterodimers that can be assembled into a wide variety of complexes. The designs are stable, folded, and soluble in isolation and rapidly assemble upon mixing, and crystal structures are close to the computational models. We construct linearly arranged hetero-oligomers with up to six different components, branched hetero-oligomers, closed C4-symmetric two-component rings, and hetero-oligomers assembled on a cyclic homo-oligomeric central hub and demonstrate that such complexes can readily reconfigure through subunit exchange. Our approach provides a general route to designing asymmetric reconfigurable protein systems."}],"publication_status":"published","citation":{"mla":"Sahtoe, Danny D., et al. “Reconfigurable Asymmetric Protein Assemblies through Implicit Negative Design.” <i>Science</i>, vol. 375, no. 6578, abj7662, American Association for the Advancement of Science, 2022, doi:<a href=\"https://doi.org/10.1126/science.abj7662\">10.1126/science.abj7662</a>.","ama":"Sahtoe DD, Praetorius FM, Courbet A, et al. Reconfigurable asymmetric protein assemblies through implicit negative design. <i>Science</i>. 2022;375(6578). doi:<a href=\"https://doi.org/10.1126/science.abj7662\">10.1126/science.abj7662</a>","ista":"Sahtoe DD, Praetorius FM, Courbet A, Hsia Y, Wicky BIM, Edman NI, Miller LM, Timmermans BJR, Decarreau J, Morris HM, Kang A, Bera AK, Baker D. 2022. Reconfigurable asymmetric protein assemblies through implicit negative design. Science. 375(6578), abj7662.","short":"D.D. Sahtoe, F.M. Praetorius, A. Courbet, Y. Hsia, B.I.M. Wicky, N.I. Edman, L.M. Miller, B.J.R. Timmermans, J. Decarreau, H.M. Morris, A. Kang, A.K. Bera, D. Baker, Science 375 (2022).","apa":"Sahtoe, D. D., Praetorius, F. M., Courbet, A., Hsia, Y., Wicky, B. I. M., Edman, N. I., … Baker, D. (2022). Reconfigurable asymmetric protein assemblies through implicit negative design. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.abj7662\">https://doi.org/10.1126/science.abj7662</a>","ieee":"D. D. Sahtoe <i>et al.</i>, “Reconfigurable asymmetric protein assemblies through implicit negative design,” <i>Science</i>, vol. 375, no. 6578. American Association for the Advancement of Science, 2022.","chicago":"Sahtoe, Danny D., Florian M Praetorius, Alexis Courbet, Yang Hsia, Basile I. M. Wicky, Natasha I. Edman, Lauren M. Miller, et al. “Reconfigurable Asymmetric Protein Assemblies through Implicit Negative Design.” <i>Science</i>. American Association for the Advancement of Science, 2022. <a href=\"https://doi.org/10.1126/science.abj7662\">https://doi.org/10.1126/science.abj7662</a>."},"article_number":"abj7662","external_id":{"pmid":["35050655"]},"title":"Reconfigurable asymmetric protein assemblies through implicit negative design","year":"2022","doi":"10.1126/science.abj7662","issue":"6578","publication":"Science","status":"public","intvolume":"       375","type":"journal_article","day":"21","date_created":"2023-09-06T12:05:42Z","language":[{"iso":"eng"}],"publisher":"American Association for the Advancement of Science","scopus_import":"1","date_published":"2022-01-21T00:00:00Z","article_type":"original","month":"01"},{"status":"public","intvolume":"       377","type":"journal_article","day":"12","page":"710-711","issue":"6607","publication":"Science","language":[{"iso":"eng"}],"publisher":"American Association for the Advancement of Science","scopus_import":"1","date_published":"2022-08-12T00:00:00Z","article_type":"letter_note","month":"08","date_created":"2022-08-28T22:02:00Z","department":[{"_id":"JePa"}],"author":[{"first_name":"Jérémie A","orcid":"0000-0002-7253-9465","full_name":"Palacci, Jérémie A","last_name":"Palacci","id":"8fb92548-2b22-11eb-b7c1-a3f0d08d7c7d"}],"abstract":[{"lang":"eng","text":"If you mix fruit syrups with alcohol to make a schnapps, the two liquids will remain perfectly blended forever. But if you mix oil with vinegar to make a vinaigrette, the oil and vinegar will soon separate back into their previous selves. Such liquid-liquid phase separation is a thermodynamically driven phenomenon and plays an important role in many biological processes (1). Although energy injection at the macroscale can reverse the phase separation—a strong shake is the normal response to a separated vinaigrette—little is known about the effect of energy added at the microscopic level on phase separation. This fundamental question has deep ramifications, notably in biology, because active processes also make the interior of a living cell different from a dead one. On page 768 of this issue, Adkins et al. (2) examine how mechanical activity at the microscopic scale affects liquid-liquid phase separation and allows liquids to climb surfaces."}],"publication_status":"published","citation":{"chicago":"Palacci, Jérémie A. “A Soft Active Matter That Can Climb Walls.” <i>Science</i>. American Association for the Advancement of Science, 2022. <a href=\"https://doi.org/10.1126/science.adc9202\">https://doi.org/10.1126/science.adc9202</a>.","ieee":"J. A. Palacci, “A soft active matter that can climb walls,” <i>Science</i>, vol. 377, no. 6607. American Association for the Advancement of Science, pp. 710–711, 2022.","apa":"Palacci, J. A. (2022). A soft active matter that can climb walls. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.adc9202\">https://doi.org/10.1126/science.adc9202</a>","ista":"Palacci JA. 2022. A soft active matter that can climb walls. Science. 377(6607), 710–711.","short":"J.A. Palacci, Science 377 (2022) 710–711.","ama":"Palacci JA. A soft active matter that can climb walls. <i>Science</i>. 2022;377(6607):710-711. doi:<a href=\"https://doi.org/10.1126/science.adc9202\">10.1126/science.adc9202</a>","mla":"Palacci, Jérémie A. “A Soft Active Matter That Can Climb Walls.” <i>Science</i>, vol. 377, no. 6607, American Association for the Advancement of Science, 2022, pp. 710–11, doi:<a href=\"https://doi.org/10.1126/science.adc9202\">10.1126/science.adc9202</a>."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","quality_controlled":"1","oa_version":"None","pmid":1,"_id":"11996","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"volume":377,"date_updated":"2022-09-05T07:37:37Z","article_processing_charge":"No","title":"A soft active matter that can climb walls","external_id":{"pmid":["35951689 "]},"year":"2022","doi":"10.1126/science.adc9202"},{"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1126/science.adg0797"}],"isi":1,"year":"2022","doi":"10.1126/science.adg0797","external_id":{"isi":["000963463700023"]},"title":"Remote opportunities for scholars in Ukraine","oa":1,"date_updated":"2023-10-03T11:01:06Z","volume":378,"article_processing_charge":"No","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","quality_controlled":"1","oa_version":"Published Version","_id":"12116","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"publication_status":"published","citation":{"short":"K. Chhugani, A. Frolova, Y. Salyha, A. Fiscutean, O. Zlenko, S. Reinsone, W.W. Wolfsberger, O.V. Ivashchenko, M. Maci, D. Dziuba, A. Parkhomenko, E. Bortz, F. Kondrashov, P.P. Łabaj, V. Romero, J. Hlávka, T.K. Oleksyk, S. Mangul, Science 378 (2022) 1285–1286.","ista":"Chhugani K, Frolova A, Salyha Y, Fiscutean A, Zlenko O, Reinsone S, Wolfsberger WW, Ivashchenko OV, Maci M, Dziuba D, Parkhomenko A, Bortz E, Kondrashov F, Łabaj PP, Romero V, Hlávka J, Oleksyk TK, Mangul S. 2022. Remote opportunities for scholars in Ukraine. Science. 378(6626), 1285–1286.","ama":"Chhugani K, Frolova A, Salyha Y, et al. Remote opportunities for scholars in Ukraine. <i>Science</i>. 2022;378(6626):1285-1286. doi:<a href=\"https://doi.org/10.1126/science.adg0797\">10.1126/science.adg0797</a>","mla":"Chhugani, Karishma, et al. “Remote Opportunities for Scholars in Ukraine.” <i>Science</i>, vol. 378, no. 6626, American Association for the Advancement of Science, 2022, pp. 1285–86, doi:<a href=\"https://doi.org/10.1126/science.adg0797\">10.1126/science.adg0797</a>.","chicago":"Chhugani, Karishma, Alina Frolova, Yuriy Salyha, Andrada Fiscutean, Oksana Zlenko, Sanita Reinsone, Walter W. Wolfsberger, et al. “Remote Opportunities for Scholars in Ukraine.” <i>Science</i>. American Association for the Advancement of Science, 2022. <a href=\"https://doi.org/10.1126/science.adg0797\">https://doi.org/10.1126/science.adg0797</a>.","ieee":"K. Chhugani <i>et al.</i>, “Remote opportunities for scholars in Ukraine,” <i>Science</i>, vol. 378, no. 6626. American Association for the Advancement of Science, pp. 1285–1286, 2022.","apa":"Chhugani, K., Frolova, A., Salyha, Y., Fiscutean, A., Zlenko, O., Reinsone, S., … Mangul, S. (2022). Remote opportunities for scholars in Ukraine. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.adg0797\">https://doi.org/10.1126/science.adg0797</a>"},"author":[{"full_name":"Chhugani, Karishma","last_name":"Chhugani","first_name":"Karishma"},{"first_name":"Alina","last_name":"Frolova","full_name":"Frolova, Alina"},{"first_name":"Yuriy","full_name":"Salyha, Yuriy","last_name":"Salyha"},{"first_name":"Andrada","last_name":"Fiscutean","full_name":"Fiscutean, Andrada"},{"last_name":"Zlenko","full_name":"Zlenko, Oksana","first_name":"Oksana"},{"first_name":"Sanita","full_name":"Reinsone, Sanita","last_name":"Reinsone"},{"full_name":"Wolfsberger, Walter W.","last_name":"Wolfsberger","first_name":"Walter W."},{"full_name":"Ivashchenko, Oleksandra V.","last_name":"Ivashchenko","first_name":"Oleksandra V."},{"first_name":"Megi","full_name":"Maci, Megi","last_name":"Maci"},{"first_name":"Dmytro","full_name":"Dziuba, Dmytro","last_name":"Dziuba"},{"first_name":"Andrii","full_name":"Parkhomenko, Andrii","last_name":"Parkhomenko"},{"first_name":"Eric","last_name":"Bortz","full_name":"Bortz, Eric"},{"id":"44FDEF62-F248-11E8-B48F-1D18A9856A87","first_name":"Fyodor","last_name":"Kondrashov","full_name":"Kondrashov, Fyodor","orcid":"0000-0001-8243-4694"},{"first_name":"Paweł P.","last_name":"Łabaj","full_name":"Łabaj, Paweł P."},{"last_name":"Romero","full_name":"Romero, Veronika","first_name":"Veronika"},{"first_name":"Jakub","full_name":"Hlávka, Jakub","last_name":"Hlávka"},{"first_name":"Taras K.","full_name":"Oleksyk, Taras K.","last_name":"Oleksyk"},{"first_name":"Serghei","full_name":"Mangul, Serghei","last_name":"Mangul"}],"abstract":[{"lang":"eng","text":"Russia’s unprovoked attack on Ukraine has destroyed civilian infrastructure, including universities, research centers, and other academic infrastructure (1). Many Ukrainian scholars and researchers remain in Ukraine, and their work has suffered from major setbacks (2–4). We call on international scientists and institutions to support them."}],"department":[{"_id":"FyKo"}],"date_created":"2023-01-12T11:56:30Z","date_published":"2022-12-22T00:00:00Z","article_type":"letter_note","month":"12","language":[{"iso":"eng"}],"publisher":"American Association for the Advancement of Science","scopus_import":"1","page":"1285-1286","issue":"6626","publication":"Science","type":"journal_article","day":"22","status":"public","intvolume":"       378"},{"page":"678-679","issue":"6530","publication":"Science","status":"public","intvolume":"       371","type":"journal_article","day":"12","date_created":"2022-03-03T09:51:48Z","department":[{"_id":"MaIb"}],"language":[{"iso":"eng"}],"publisher":"American Association for the Advancement of Science","scopus_import":"1","date_published":"2021-02-12T00:00:00Z","article_type":"letter_note","month":"02","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","quality_controlled":"1","oa_version":"None","pmid":1,"_id":"10809","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"volume":371,"date_updated":"2023-08-17T07:00:35Z","article_processing_charge":"No","keyword":["multidisciplinary"],"author":[{"id":"2A70014E-F248-11E8-B48F-1D18A9856A87","first_name":"Yu","orcid":"0000-0001-7313-6740","last_name":"Liu","full_name":"Liu, Yu"},{"first_name":"Maria","full_name":"Ibáñez, Maria","last_name":"Ibáñez","orcid":"0000-0001-5013-2843","id":"43C61214-F248-11E8-B48F-1D18A9856A87"}],"abstract":[{"lang":"eng","text":"Thermoelectric materials are engines that convert heat into an electrical current. Intuitively, the efficiency of this process depends on how many electrons (charge carriers) can move and how easily they do so, how much energy those moving electrons transport, and how easily the temperature gradient is maintained. In terms of material properties, an excellent thermoelectric material requires a high electrical conductivity σ, a high Seebeck coefficient S (a measure of the induced thermoelectric voltage as a function of temperature gradient), and a low thermal conductivity κ. The challenge is that these three properties are strongly interrelated in a conflicting manner (1). On page 722 of this issue, Roychowdhury et al. (2) have found a way to partially break these ties in silver antimony telluride (AgSbTe2) with the addition of cadmium (Cd) cations, which increase the ordering in this inherently disordered thermoelectric material."}],"publication_status":"published","citation":{"chicago":"Liu, Yu, and Maria Ibáñez. “Tidying up the Mess.” <i>Science</i>. American Association for the Advancement of Science, 2021. <a href=\"https://doi.org/10.1126/science.abg0886\">https://doi.org/10.1126/science.abg0886</a>.","ieee":"Y. Liu and M. Ibáñez, “Tidying up the mess,” <i>Science</i>, vol. 371, no. 6530. American Association for the Advancement of Science, pp. 678–679, 2021.","apa":"Liu, Y., &#38; Ibáñez, M. (2021). Tidying up the mess. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.abg0886\">https://doi.org/10.1126/science.abg0886</a>","ista":"Liu Y, Ibáñez M. 2021. Tidying up the mess. Science. 371(6530), 678–679.","short":"Y. Liu, M. Ibáñez, Science 371 (2021) 678–679.","mla":"Liu, Yu, and Maria Ibáñez. “Tidying up the Mess.” <i>Science</i>, vol. 371, no. 6530, American Association for the Advancement of Science, 2021, pp. 678–79, doi:<a href=\"https://doi.org/10.1126/science.abg0886\">10.1126/science.abg0886</a>.","ama":"Liu Y, Ibáñez M. Tidying up the mess. <i>Science</i>. 2021;371(6530):678-679. doi:<a href=\"https://doi.org/10.1126/science.abg0886\">10.1126/science.abg0886</a>"},"isi":1,"title":"Tidying up the mess","external_id":{"isi":["000617551600027"],"pmid":["33574201"]},"doi":"10.1126/science.abg0886","year":"2021"},{"intvolume":"       371","status":"public","day":"26","type":"journal_article","issue":"6536","publication":"Science","page":"1355-1359","file_date_updated":"2021-09-23T14:00:05Z","publisher":"AAAS","scopus_import":"1","language":[{"iso":"eng"}],"month":"03","article_type":"original","date_published":"2021-03-26T00:00:00Z","date_created":"2021-06-29T12:04:05Z","file":[{"content_type":"application/pdf","relation":"main_file","file_id":"10040","creator":"patrickd","success":1,"date_updated":"2021-09-23T14:00:05Z","access_level":"open_access","file_name":"scars_subharmonic_combined_manuscript_2_11_2021 (2)-1.pdf","file_size":3671159,"date_created":"2021-09-23T14:00:05Z","checksum":"0b356fd10ab9bb95177d4c047d4e9c1a"}],"has_accepted_license":"1","department":[{"_id":"MaSe"}],"abstract":[{"lang":"eng","text":"The control of nonequilibrium quantum dynamics in many-body systems is challenging because interactions typically lead to thermalization and a chaotic spreading throughout Hilbert space. We investigate nonequilibrium dynamics after rapid quenches in a many-body system composed of 3 to 200 strongly interacting qubits in one and two spatial dimensions. Using a programmable quantum simulator based on Rydberg atom arrays, we show that coherent revivals associated with so-called quantum many-body scars can be stabilized by periodic driving, which generates a robust subharmonic response akin to discrete time-crystalline order. We map Hilbert space dynamics, geometry dependence, phase diagrams, and system-size dependence of this emergent phenomenon, demonstrating new ways to steer complex dynamics in many-body systems and enabling potential applications in quantum information science."}],"keyword":["Multidisciplinary"],"author":[{"first_name":"D.","last_name":"Bluvstein","full_name":"Bluvstein, D."},{"full_name":"Omran, A.","last_name":"Omran","first_name":"A."},{"full_name":"Levine, H.","last_name":"Levine","first_name":"H."},{"first_name":"A.","full_name":"Keesling, A.","last_name":"Keesling"},{"full_name":"Semeghini, G.","last_name":"Semeghini","first_name":"G."},{"full_name":"Ebadi, S.","last_name":"Ebadi","first_name":"S."},{"first_name":"T. T.","full_name":"Wang, T. T.","last_name":"Wang"},{"id":"36EBAD38-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8443-1064","last_name":"Michailidis","full_name":"Michailidis, Alexios","first_name":"Alexios"},{"full_name":"Maskara, N.","last_name":"Maskara","first_name":"N."},{"full_name":"Ho, W. W.","last_name":"Ho","first_name":"W. W."},{"first_name":"S.","full_name":"Choi, S.","last_name":"Choi"},{"first_name":"Maksym","last_name":"Serbyn","full_name":"Serbyn, Maksym","orcid":"0000-0002-2399-5827","id":"47809E7E-F248-11E8-B48F-1D18A9856A87"},{"first_name":"M.","full_name":"Greiner, M.","last_name":"Greiner"},{"first_name":"V.","full_name":"Vuletić, V.","last_name":"Vuletić"},{"first_name":"M. D.","last_name":"Lukin","full_name":"Lukin, M. D."}],"publication_status":"published","citation":{"ista":"Bluvstein D, Omran A, Levine H, Keesling A, Semeghini G, Ebadi S, Wang TT, Michailidis A, Maskara N, Ho WW, Choi S, Serbyn M, Greiner M, Vuletić V, Lukin MD. 2021. Controlling quantum many-body dynamics in driven Rydberg atom arrays. Science. 371(6536), 1355–1359.","short":"D. Bluvstein, A. Omran, H. Levine, A. Keesling, G. Semeghini, S. Ebadi, T.T. Wang, A. Michailidis, N. Maskara, W.W. Ho, S. Choi, M. Serbyn, M. Greiner, V. Vuletić, M.D. Lukin, Science 371 (2021) 1355–1359.","mla":"Bluvstein, D., et al. “Controlling Quantum Many-Body Dynamics in Driven Rydberg Atom Arrays.” <i>Science</i>, vol. 371, no. 6536, AAAS, 2021, pp. 1355–59, doi:<a href=\"https://doi.org/10.1126/science.abg2530\">10.1126/science.abg2530</a>.","ama":"Bluvstein D, Omran A, Levine H, et al. Controlling quantum many-body dynamics in driven Rydberg atom arrays. <i>Science</i>. 2021;371(6536):1355-1359. doi:<a href=\"https://doi.org/10.1126/science.abg2530\">10.1126/science.abg2530</a>","chicago":"Bluvstein, D., A. Omran, H. Levine, A. Keesling, G. Semeghini, S. Ebadi, T. T. Wang, et al. “Controlling Quantum Many-Body Dynamics in Driven Rydberg Atom Arrays.” <i>Science</i>. AAAS, 2021. <a href=\"https://doi.org/10.1126/science.abg2530\">https://doi.org/10.1126/science.abg2530</a>.","ieee":"D. Bluvstein <i>et al.</i>, “Controlling quantum many-body dynamics in driven Rydberg atom arrays,” <i>Science</i>, vol. 371, no. 6536. AAAS, pp. 1355–1359, 2021.","apa":"Bluvstein, D., Omran, A., Levine, H., Keesling, A., Semeghini, G., Ebadi, S., … Lukin, M. D. (2021). Controlling quantum many-body dynamics in driven Rydberg atom arrays. <i>Science</i>. AAAS. <a href=\"https://doi.org/10.1126/science.abg2530\">https://doi.org/10.1126/science.abg2530</a>"},"pmid":1,"_id":"9618","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"acknowledgement":"We thank many members of the Harvard AMO community, particularly E. Urbach, S. Dakoulas, and J. Doyle for their efforts enabling safe and productive operation of our laboratories during 2020. We thank D. Abanin, I. Cong, F. Machado, H. Pichler, N. Yao, B. Ye, and H. Zhou for stimulating discussions. Funding: We acknowledge financial support from the Center for Ultracold Atoms, the National Science Foundation, the Vannevar Bush Faculty Fellowship, the U.S. Department of Energy (LBNL QSA Center and grant no. DE-SC0021013), the Office of Naval Research, the Army Research Office MURI, the DARPA DRINQS program (grant no. D18AC00033), and the DARPA ONISQ program (grant no. W911NF2010021). The authors acknowledge support from the NSF Graduate Research Fellowship Program (grant DGE1745303) and The Fannie and John Hertz Foundation (D.B.); a National Defense Science and Engineering Graduate (NDSEG) fellowship (H.L.); a fellowship from the Max Planck/Harvard Research Center for Quantum Optics (G.S.); Gordon College (T.T.W.); the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement no. 850899) (A.A.M. and M.S.); a Department of Energy Computational Science Graduate Fellowship under award number DE-SC0021110 (N.M.); the Moore Foundation’s EPiQS Initiative grant no. GBMF4306, the NUS Development grant AY2019/2020, and the Stanford Institute of Theoretical Physics (W.W.H.); and the Miller Institute for Basic Research in Science (S.C.). Author contributions: D.B., A.O., H.L., A.K., G.S., S.E., and T.T.W. contributed to the building of the experimental setup, performed the measurements, and analyzed the data. A.A.M., N.M., W.W.H., S.C., and M.S. performed theoretical analysis. All work was supervised by M.G., V.V., and M.D.L. All authors discussed the results and contributed to the manuscript. Competing interests: M.G., V.V., and M.D.L. are co-founders and shareholders of QuEra Computing. A.O. is a shareholder of QuEra Computing. Data and materials availability: All data needed to evaluate the conclusions in the paper are present in the paper and the supplementary materials.","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","quality_controlled":"1","project":[{"call_identifier":"H2020","_id":"23841C26-32DE-11EA-91FC-C7463DDC885E","name":"Non-Ergodic Quantum Matter: Universality, Dynamics and Control","grant_number":"850899"}],"oa_version":"Preprint","arxiv":1,"date_updated":"2023-08-10T13:57:07Z","oa":1,"volume":371,"article_processing_charge":"No","external_id":{"isi":["000636043400048"],"arxiv":["2012.12276"],"pmid":["33632894"]},"title":"Controlling quantum many-body dynamics in driven Rydberg atom arrays","year":"2021","doi":"10.1126/science.abg2530","ec_funded":1,"ddc":["539"],"isi":1},{"month":"05","date_published":"2021-05-27T00:00:00Z","article_type":"original","scopus_import":"1","publisher":"American Association for the Advancement of Science","language":[{"iso":"eng"}],"date_created":"2022-01-13T12:17:45Z","day":"27","type":"journal_article","intvolume":"       372","status":"public","publication":"Science","issue":"6548","page":"1323-1327","year":"2021","doi":"10.1126/science.abd3190","external_id":{"pmid":["34045322"],"arxiv":["2006.08053"]},"title":"Imaging orbital ferromagnetism in a moiré Chern insulator","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2006.08053"}],"citation":{"short":"C.L. Tschirhart, M. Serlin, H. Polshyn, A. Shragai, Z. Xia, J. Zhu, Y. Zhang, K. Watanabe, T. Taniguchi, M.E. Huber, A.F. Young, Science 372 (2021) 1323–1327.","ista":"Tschirhart CL, Serlin M, Polshyn H, Shragai A, Xia Z, Zhu J, Zhang Y, Watanabe K, Taniguchi T, Huber ME, Young AF. 2021. Imaging orbital ferromagnetism in a moiré Chern insulator. Science. 372(6548), 1323–1327.","ama":"Tschirhart CL, Serlin M, Polshyn H, et al. Imaging orbital ferromagnetism in a moiré Chern insulator. <i>Science</i>. 2021;372(6548):1323-1327. doi:<a href=\"https://doi.org/10.1126/science.abd3190\">10.1126/science.abd3190</a>","mla":"Tschirhart, C. L., et al. “Imaging Orbital Ferromagnetism in a Moiré Chern Insulator.” <i>Science</i>, vol. 372, no. 6548, American Association for the Advancement of Science, 2021, pp. 1323–27, doi:<a href=\"https://doi.org/10.1126/science.abd3190\">10.1126/science.abd3190</a>.","chicago":"Tschirhart, C. L., M. Serlin, Hryhoriy Polshyn, A. Shragai, Z. Xia, J. Zhu, Y. Zhang, et al. “Imaging Orbital Ferromagnetism in a Moiré Chern Insulator.” <i>Science</i>. American Association for the Advancement of Science, 2021. <a href=\"https://doi.org/10.1126/science.abd3190\">https://doi.org/10.1126/science.abd3190</a>.","ieee":"C. L. Tschirhart <i>et al.</i>, “Imaging orbital ferromagnetism in a moiré Chern insulator,” <i>Science</i>, vol. 372, no. 6548. American Association for the Advancement of Science, pp. 1323–1327, 2021.","apa":"Tschirhart, C. L., Serlin, M., Polshyn, H., Shragai, A., Xia, Z., Zhu, J., … Young, A. F. (2021). Imaging orbital ferromagnetism in a moiré Chern insulator. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.abd3190\">https://doi.org/10.1126/science.abd3190</a>"},"publication_status":"published","abstract":[{"text":"Electrons in moiré flat band systems can spontaneously break time-reversal symmetry, giving rise to a quantized anomalous Hall effect. In this study, we use a superconducting quantum interference device to image stray magnetic fields in twisted bilayer graphene aligned to hexagonal boron nitride. We find a magnetization of several Bohr magnetons per charge carrier, demonstrating that the magnetism is primarily orbital in nature. Our measurements reveal a large change in the magnetization as the chemical potential is swept across the quantum anomalous Hall gap, consistent with the expected contribution of chiral edge states to the magnetization of an orbital Chern insulator. Mapping the spatial evolution of field-driven magnetic reversal, we find a series of reproducible micrometer-scale domains pinned to structural disorder.","lang":"eng"}],"keyword":["multidisciplinary"],"author":[{"last_name":"Tschirhart","full_name":"Tschirhart, C. L.","first_name":"C. L."},{"full_name":"Serlin, M.","last_name":"Serlin","first_name":"M."},{"last_name":"Polshyn","full_name":"Polshyn, Hryhoriy","orcid":"0000-0001-8223-8896","first_name":"Hryhoriy","id":"edfc7cb1-526e-11ec-b05a-e6ecc27e4e48"},{"first_name":"A.","last_name":"Shragai","full_name":"Shragai, A."},{"full_name":"Xia, Z.","last_name":"Xia","first_name":"Z."},{"first_name":"J.","last_name":"Zhu","full_name":"Zhu, J."},{"first_name":"Y.","full_name":"Zhang, Y.","last_name":"Zhang"},{"first_name":"K.","full_name":"Watanabe, K.","last_name":"Watanabe"},{"full_name":"Taniguchi, T.","last_name":"Taniguchi","first_name":"T."},{"full_name":"Huber, M. E.","last_name":"Huber","first_name":"M. E."},{"full_name":"Young, A. F.","last_name":"Young","first_name":"A. F."}],"arxiv":1,"article_processing_charge":"No","oa":1,"date_updated":"2022-01-13T14:11:36Z","volume":372,"publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"extern":"1","_id":"10616","pmid":1,"quality_controlled":"1","oa_version":"Preprint","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","acknowledgement":"We thank A. H. Macdonald, J. Zhu, M. Zaletel, and D. Xiao for discussions of the results and E. Lachman for comments on the manuscript. Funding: The work was primarily funded by the US Department of Energy under DE-SC0020043, with additional support for instrumentation development supported by the Army Research Office under grant W911NF-16-1-0361. K.W. and T.T. acknowledge support from the Elemental Strategy Initiative conducted by MEXT, Japan, grant JPMXP0112101001; JSPS KAKENHI grant JP20H00354 and CREST grant JPMJCR15F3, JST. C.L.T. acknowledges support from the Hertz Foundation and from the National Science Foundation Graduate Research Fellowship Program under grant 1650114. This project is funded in part by the Gordon and Betty Moore Foundation’s EPiQS Initiative, grant GBMF9471 to A.F.Y."},{"author":[{"first_name":"Jincheng","last_name":"Long","full_name":"Long, Jincheng"},{"full_name":"Walker, James","last_name":"Walker","first_name":"James"},{"full_name":"She, Wenjing","last_name":"She","first_name":"Wenjing"},{"last_name":"Aldridge","full_name":"Aldridge, Billy","first_name":"Billy"},{"first_name":"Hongbo","full_name":"Gao, Hongbo","last_name":"Gao"},{"last_name":"Deans","full_name":"Deans, Samuel","first_name":"Samuel"},{"last_name":"Vickers","full_name":"Vickers, Martin","first_name":"Martin"},{"id":"e0164712-22ee-11ed-b12a-d80fcdf35958","orcid":"0000-0002-4008-1234","full_name":"Feng, Xiaoqi","last_name":"Feng","first_name":"Xiaoqi"}],"keyword":["Multidisciplinary"],"abstract":[{"text":"Genomes of germ cells present an existential vulnerability to organisms because germ cell mutations will propagate to future generations. Transposable elements are one source of such mutations. In the small flowering plant Arabidopsis, Long et al. found that genome methylation in the male germline is directed by small interfering RNAs (siRNAs) imperfectly transcribed from transposons (see the Perspective by Mosher). These germline siRNAs silence germline transposons and establish inherited methylation patterns in sperm, thus maintaining the integrity of the plant genome across generations.","lang":"eng"}],"citation":{"chicago":"Long, Jincheng, James Walker, Wenjing She, Billy Aldridge, Hongbo Gao, Samuel Deans, Martin Vickers, and Xiaoqi Feng. “Nurse Cell--Derived Small RNAs Define Paternal Epigenetic Inheritance in Arabidopsis.” <i>Science</i>. American Association for the Advancement of Science (AAAS), 2021. <a href=\"https://doi.org/10.1126/science.abh0556\">https://doi.org/10.1126/science.abh0556</a>.","ieee":"J. Long <i>et al.</i>, “Nurse cell--derived small RNAs define paternal epigenetic inheritance in Arabidopsis,” <i>Science</i>, vol. 373, no. 6550. American Association for the Advancement of Science (AAAS), 2021.","apa":"Long, J., Walker, J., She, W., Aldridge, B., Gao, H., Deans, S., … Feng, X. (2021). Nurse cell--derived small RNAs define paternal epigenetic inheritance in Arabidopsis. <i>Science</i>. American Association for the Advancement of Science (AAAS). <a href=\"https://doi.org/10.1126/science.abh0556\">https://doi.org/10.1126/science.abh0556</a>","short":"J. Long, J. Walker, W. She, B. Aldridge, H. Gao, S. Deans, M. Vickers, X. Feng, Science 373 (2021).","ista":"Long J, Walker J, She W, Aldridge B, Gao H, Deans S, Vickers M, Feng X. 2021. Nurse cell--derived small RNAs define paternal epigenetic inheritance in Arabidopsis. Science. 373(6550).","ama":"Long J, Walker J, She W, et al. Nurse cell--derived small RNAs define paternal epigenetic inheritance in Arabidopsis. <i>Science</i>. 2021;373(6550). doi:<a href=\"https://doi.org/10.1126/science.abh0556\">10.1126/science.abh0556</a>","mla":"Long, Jincheng, et al. “Nurse Cell--Derived Small RNAs Define Paternal Epigenetic Inheritance in Arabidopsis.” <i>Science</i>, vol. 373, no. 6550, American Association for the Advancement of Science (AAAS), 2021, doi:<a href=\"https://doi.org/10.1126/science.abh0556\">10.1126/science.abh0556</a>."},"publication_status":"published","oa_version":"None","quality_controlled":"1","acknowledgement":"We thank the John Innes Centre Bioimaging Facility (S. Lopez, E. Wegel, and K. Findlay) for their assistance with microscopy and the Norwich BioScience Institute Partnership Computing Infrastructure for Science Group for high-performance computing resources. Funding: This work was funded by a European Research Council Starting Grant (“SexMeth” 804981; J.L., J.W., and X.F.), a Sainsbury Charitable Foundation studentship (J.W.), two Biotechnology and Biological Sciences Research Council (BBSRC) grants (BBS0096201 and BBP0135111; W.S., M.V., and X.F.), two John Innes Foundation studentships (B.A. and S.D.), and a BBSRC David Phillips Fellowship (BBL0250431; H.G. and X.F.). Author contributions: J.L., J.W., and X.F. designed the study and wrote the manuscript; J.L., W.S., B.A., H.G., and S.D. performed the experiments; and J.L., J.W., B.A., H.G., S.D., M.V., and X.F. analyzed the data. Competing interests: The authors declare no competing interests. Data and material availability: All sequencing data have been deposited in the Gene Expression Omnibus (GEO) under accession no. GSE161625. Accession nos. of published datasets used in this study are listed in table S6. Published software used in this study include Bowtie v1.2.2 (https://doi.org/10.1002/0471250953.bi1107s32), Bismark v0.22.2 (https://doi.org/10.1093/bioinformatics/btr167), Kallisto v0.43.0 (https://doi.org/10.1038/nbt0816-888d), Shortstack v3.8.5 (https://doi.org/10.1534/g3.116.030452), and Cutadapt v1.15 (https://doi.org/10.1089/cmb.2017.0096). TrimGalore v0.4.1 and MarkDuplicates v1.141 are available from https://github.com/FelixKrueger/TrimGalore and https://github.com/broadinstitute/picard, respectively. All remaining data are in the main paper or the supplementary materials.","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","extern":"1","publication_identifier":{"issn":["0036-8075","1095-9203"]},"_id":"12187","pmid":1,"article_processing_charge":"No","date_updated":"2023-05-08T10:56:39Z","volume":373,"title":"Nurse cell--derived small RNAs define paternal epigenetic inheritance in Arabidopsis","external_id":{"pmid":["34210850"]},"doi":"10.1126/science.abh0556","year":"2021","status":"public","intvolume":"       373","type":"journal_article","day":"02","publication":"Science","issue":"6550","language":[{"iso":"eng"}],"scopus_import":"1","publisher":"American Association for the Advancement of Science (AAAS)","date_published":"2021-07-02T00:00:00Z","article_type":"original","month":"07","date_created":"2023-01-16T09:15:14Z","department":[{"_id":"XiFe"}]},{"acknowledgement":"We thank the members of the Megason and Heisenberg labs for critical discussions of and technical assistance during the work and B. Appel, S. Holley, J. Jontes, and D. Gilmour for transgenic fish. This work is supported by the Damon Runyon Cancer Foundation, a NICHD K99 fellowship (1K99HD092623), a Travelling Fellowship of the Company of Biologists, a Collaborative Research grant from the Burroughs Wellcome Foundation (T.Y.-C.T.), NIH grant  01GM107733 (T.Y.-C.T. and S.G.M.), NIH grant R01NS102322 (T.C.-C. and H.K.), and an ERC advanced grant\r\n(MECSPEC) (C.-P.H.).","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","project":[{"grant_number":"742573","_id":"260F1432-B435-11E9-9278-68D0E5697425","name":"Interaction and feedback between cell mechanics and fate specification in vertebrate gastrulation","call_identifier":"H2020"}],"quality_controlled":"1","oa_version":"Preprint","_id":"8680","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"volume":370,"date_updated":"2023-08-22T10:36:35Z","oa":1,"article_processing_charge":"No","keyword":["Multidisciplinary"],"author":[{"last_name":"Tsai","full_name":"Tsai, Tony Y.-C.","first_name":"Tony Y.-C."},{"id":"2F74BCDE-F248-11E8-B48F-1D18A9856A87","first_name":"Mateusz K","last_name":"Sikora","full_name":"Sikora, Mateusz K"},{"last_name":"Xia","full_name":"Xia, Peng","orcid":"0000-0002-5419-7756","first_name":"Peng","id":"4AB6C7D0-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Tugba","full_name":"Colak-Champollion, Tugba","last_name":"Colak-Champollion"},{"full_name":"Knaut, Holger","last_name":"Knaut","first_name":"Holger"},{"id":"39427864-F248-11E8-B48F-1D18A9856A87","full_name":"Heisenberg, Carl-Philipp J","last_name":"Heisenberg","orcid":"0000-0002-0912-4566","first_name":"Carl-Philipp J"},{"last_name":"Megason","full_name":"Megason, Sean G.","first_name":"Sean G."}],"abstract":[{"text":"Animal development entails the organization of specific cell types in space and time, and spatial patterns must form in a robust manner. In the zebrafish spinal cord, neural progenitors form stereotypic patterns despite noisy morphogen signaling and large-scale cellular rearrangements during morphogenesis and growth. By directly measuring adhesion forces and preferences for three types of endogenous neural progenitors, we provide evidence for the differential adhesion model in which differences in intercellular adhesion mediate cell sorting. Cell type–specific combinatorial expression of different classes of cadherins (N-cadherin, cadherin 11, and protocadherin 19) results in homotypic preference ex vivo and patterning robustness in vivo. Furthermore, the differential adhesion code is regulated by the sonic hedgehog morphogen gradient. We propose that robust patterning during tissue morphogenesis results from interplay between adhesion-based self-organization and morphogen-directed patterning.","lang":"eng"}],"publication_status":"published","citation":{"mla":"Tsai, Tony Y. C., et al. “An Adhesion Code Ensures Robust Pattern Formation during Tissue Morphogenesis.” <i>Science</i>, vol. 370, no. 6512, American Association for the Advancement of Science, 2020, pp. 113–16, doi:<a href=\"https://doi.org/10.1126/science.aba6637\">10.1126/science.aba6637</a>.","ama":"Tsai TY-C, Sikora MK, Xia P, et al. An adhesion code ensures robust pattern formation during tissue morphogenesis. <i>Science</i>. 2020;370(6512):113-116. doi:<a href=\"https://doi.org/10.1126/science.aba6637\">10.1126/science.aba6637</a>","short":"T.Y.-C. Tsai, M.K. Sikora, P. Xia, T. Colak-Champollion, H. Knaut, C.-P.J. Heisenberg, S.G. Megason, Science 370 (2020) 113–116.","ista":"Tsai TY-C, Sikora MK, Xia P, Colak-Champollion T, Knaut H, Heisenberg C-PJ, Megason SG. 2020. An adhesion code ensures robust pattern formation during tissue morphogenesis. Science. 370(6512), 113–116.","apa":"Tsai, T. Y.-C., Sikora, M. K., Xia, P., Colak-Champollion, T., Knaut, H., Heisenberg, C.-P. J., &#38; Megason, S. G. (2020). An adhesion code ensures robust pattern formation during tissue morphogenesis. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.aba6637\">https://doi.org/10.1126/science.aba6637</a>","ieee":"T. Y.-C. Tsai <i>et al.</i>, “An adhesion code ensures robust pattern formation during tissue morphogenesis,” <i>Science</i>, vol. 370, no. 6512. American Association for the Advancement of Science, pp. 113–116, 2020.","chicago":"Tsai, Tony Y.-C., Mateusz K Sikora, Peng Xia, Tugba Colak-Champollion, Holger Knaut, Carl-Philipp J Heisenberg, and Sean G. Megason. “An Adhesion Code Ensures Robust Pattern Formation during Tissue Morphogenesis.” <i>Science</i>. American Association for the Advancement of Science, 2020. <a href=\"https://doi.org/10.1126/science.aba6637\">https://doi.org/10.1126/science.aba6637</a>."},"related_material":{"link":[{"relation":"press_release","description":"News on IST Homepage","url":"https://ist.ac.at/en/news/sticking-together/"}]},"isi":1,"main_file_link":[{"url":"https://www.biorxiv.org/content/10.1101/803635v1","open_access":"1"}],"external_id":{"isi":["000579169000053"]},"title":"An adhesion code ensures robust pattern formation during tissue morphogenesis","ec_funded":1,"doi":"10.1126/science.aba6637","year":"2020","page":"113-116","issue":"6512","publication":"Science","status":"public","intvolume":"       370","type":"journal_article","day":"02","date_created":"2020-10-19T14:09:38Z","department":[{"_id":"CaHe"}],"language":[{"iso":"eng"}],"publisher":"American Association for the Advancement of Science","scopus_import":"1","article_type":"original","date_published":"2020-10-02T00:00:00Z","month":"10"},{"page":"550-557","publication":"Science","issue":"6516","type":"journal_article","day":"30","status":"public","intvolume":"       370","department":[{"_id":"JiFr"}],"date_created":"2020-11-02T10:04:46Z","article_type":"original","date_published":"2020-10-30T00:00:00Z","month":"10","language":[{"iso":"eng"}],"scopus_import":"1","publisher":"American Association for the Advancement of Science","article_processing_charge":"No","volume":370,"date_updated":"2023-09-05T12:02:35Z","oa":1,"quality_controlled":"1","project":[{"call_identifier":"H2020","name":"Tracing Evolution of Auxin Transport and Polarity in Plants","_id":"261099A6-B435-11E9-9278-68D0E5697425","grant_number":"742985"},{"name":"Molecular mechanisms of endocytic cargo recognition in plants","_id":"26538374-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","grant_number":"I03630"},{"name":"Cell surface receptor complexes for PIN polarity and auxin-mediated development","_id":"2699E3D2-B435-11E9-9278-68D0E5697425","grant_number":"25239"}],"oa_version":"Published Version","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","acknowledgement":"We acknowledge M. Glanc and Y. Zhang for providing entryclones; Vienna Biocenter Core Facilities (VBCF) for recombinantprotein production and purification; Vienna Biocenter Massspectrometry Facility, Bioimaging, and Life Science Facilities at IST Austria and Proteomics Core Facility CEITEC for a great assistance.Funding:This project received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement 742985) and Austrian Science Fund (FWF): I 3630-B25 to J.F.and by grants from the Austrian Academy of Science through the Gregor Mendel Institute (Y.B.) and the Austrian Agency for International Cooperation in Education and Research (D.D.); the Netherlands Organization for Scientific Research (NWO; VIDI-864.13.001) (W.S.); the Research Foundation–Flanders (FWO;Odysseus II G0D0515N) and a European Research Council grant (ERC; StG TORPEDO; 714055) to B.D.R., B.Y., and E.M.; and the Hertha Firnberg Programme postdoctoral fellowship (T-947) from the FWF Austrian Science Fund to E.S.-L.; J.H. is the recipient of a DOC Fellowship of the Austrian Academy of Sciences at IST Austria.","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"_id":"8721","pmid":1,"citation":{"ista":"Hajny J, Prat T, Rydza N, Rodriguez Solovey L, Tan S, Verstraeten I, Domjan D, Mazur E, Smakowska-Luzan E, Smet W, Mor E, Nolf J, Yang B, Grunewald W, Molnar G, Belkhadir Y, De Rybel B, Friml J. 2020. Receptor kinase module targets PIN-dependent auxin transport during canalization. Science. 370(6516), 550–557.","short":"J. Hajny, T. Prat, N. Rydza, L. Rodriguez Solovey, S. Tan, I. Verstraeten, D. Domjan, E. Mazur, E. Smakowska-Luzan, W. Smet, E. Mor, J. Nolf, B. Yang, W. Grunewald, G. Molnar, Y. Belkhadir, B. De Rybel, J. Friml, Science 370 (2020) 550–557.","ama":"Hajny J, Prat T, Rydza N, et al. Receptor kinase module targets PIN-dependent auxin transport during canalization. <i>Science</i>. 2020;370(6516):550-557. doi:<a href=\"https://doi.org/10.1126/science.aba3178\">10.1126/science.aba3178</a>","mla":"Hajny, Jakub, et al. “Receptor Kinase Module Targets PIN-Dependent Auxin Transport during Canalization.” <i>Science</i>, vol. 370, no. 6516, American Association for the Advancement of Science, 2020, pp. 550–57, doi:<a href=\"https://doi.org/10.1126/science.aba3178\">10.1126/science.aba3178</a>.","chicago":"Hajny, Jakub, Tomas Prat, N Rydza, Lesia Rodriguez Solovey, Shutang Tan, Inge Verstraeten, David Domjan, et al. “Receptor Kinase Module Targets PIN-Dependent Auxin Transport during Canalization.” <i>Science</i>. American Association for the Advancement of Science, 2020. <a href=\"https://doi.org/10.1126/science.aba3178\">https://doi.org/10.1126/science.aba3178</a>.","ieee":"J. Hajny <i>et al.</i>, “Receptor kinase module targets PIN-dependent auxin transport during canalization,” <i>Science</i>, vol. 370, no. 6516. American Association for the Advancement of Science, pp. 550–557, 2020.","apa":"Hajny, J., Prat, T., Rydza, N., Rodriguez Solovey, L., Tan, S., Verstraeten, I., … Friml, J. (2020). Receptor kinase module targets PIN-dependent auxin transport during canalization. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.aba3178\">https://doi.org/10.1126/science.aba3178</a>"},"publication_status":"published","author":[{"last_name":"Hajny","full_name":"Hajny, Jakub","orcid":"0000-0003-2140-7195","first_name":"Jakub","id":"4800CC20-F248-11E8-B48F-1D18A9856A87"},{"id":"3DA3BFEE-F248-11E8-B48F-1D18A9856A87","full_name":"Prat, Tomas","last_name":"Prat","first_name":"Tomas"},{"last_name":"Rydza","full_name":"Rydza, N","first_name":"N"},{"id":"3922B506-F248-11E8-B48F-1D18A9856A87","first_name":"Lesia","orcid":"0000-0002-7244-7237","full_name":"Rodriguez Solovey, Lesia","last_name":"Rodriguez Solovey"},{"first_name":"Shutang","orcid":"0000-0002-0471-8285","full_name":"Tan, Shutang","last_name":"Tan","id":"2DE75584-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Inge","last_name":"Verstraeten","full_name":"Verstraeten, Inge","orcid":"0000-0001-7241-2328","id":"362BF7FE-F248-11E8-B48F-1D18A9856A87"},{"first_name":"David","orcid":"0000-0003-2267-106X","full_name":"Domjan, David","last_name":"Domjan","id":"C684CD7A-257E-11EA-9B6F-D8588B4F947F"},{"first_name":"E","last_name":"Mazur","full_name":"Mazur, E"},{"last_name":"Smakowska-Luzan","full_name":"Smakowska-Luzan, E","first_name":"E"},{"first_name":"W","last_name":"Smet","full_name":"Smet, W"},{"full_name":"Mor, E","last_name":"Mor","first_name":"E"},{"last_name":"Nolf","full_name":"Nolf, J","first_name":"J"},{"first_name":"B","last_name":"Yang","full_name":"Yang, B"},{"last_name":"Grunewald","full_name":"Grunewald, W","first_name":"W"},{"id":"34F1AF46-F248-11E8-B48F-1D18A9856A87","first_name":"Gergely","full_name":"Molnar, Gergely","last_name":"Molnar"},{"last_name":"Belkhadir","full_name":"Belkhadir, Y","first_name":"Y"},{"first_name":"B","full_name":"De Rybel, B","last_name":"De Rybel"},{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","first_name":"Jiří","orcid":"0000-0002-8302-7596","last_name":"Friml","full_name":"Friml, Jiří"}],"abstract":[{"lang":"eng","text":"Spontaneously arising channels that transport the phytohormone auxin provide positional cues for self-organizing aspects of plant development such as flexible vasculature regeneration or its patterning during leaf venation. The auxin canalization hypothesis proposes a feedback between auxin signaling and transport as the underlying mechanism, but molecular players await discovery. We identified part of the machinery that routes auxin transport. The auxin-regulated receptor CAMEL (Canalization-related Auxin-regulated Malectin-type RLK) together with CANAR (Canalization-related Receptor-like kinase) interact with and phosphorylate PIN auxin transporters. camel and canar mutants are impaired in PIN1 subcellular trafficking and auxin-mediated PIN polarization, which macroscopically manifests as defects in leaf venation and vasculature regeneration after wounding. The CAMEL-CANAR receptor complex is part of the auxin feedback that coordinates polarization of individual cells during auxin canalization."}],"main_file_link":[{"url":"https://europepmc.org/article/MED/33122378#free-full-text","open_access":"1"}],"isi":1,"related_material":{"link":[{"url":"https://ist.ac.at/en/news/molecular-compass-for-cell-orientation/","relation":"press_release","description":"News on IST Homepage"}]},"ec_funded":1,"year":"2020","doi":"10.1126/science.aba3178","acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}],"title":"Receptor kinase module targets PIN-dependent auxin transport during canalization","external_id":{"pmid":["33122378"],"isi":["000583031800041"]}},{"publication_status":"published","citation":{"mla":"Tarrason Risa, Gabriel, et al. “The Proteasome Controls ESCRT-III–Mediated Cell Division in an Archaeon.” <i>Science</i>, vol. 369, no. 6504, American Association for the Advancement of Science, 2020, doi:<a href=\"https://doi.org/10.1126/science.aaz2532\">10.1126/science.aaz2532</a>.","ama":"Tarrason Risa G, Hurtig F, Bray S, et al. The proteasome controls ESCRT-III–mediated cell division in an archaeon. <i>Science</i>. 2020;369(6504). doi:<a href=\"https://doi.org/10.1126/science.aaz2532\">10.1126/science.aaz2532</a>","ista":"Tarrason Risa G, Hurtig F, Bray S, Hafner AE, Harker-Kirschneck L, Faull P, Davis C, Papatziamou D, Mutavchiev DR, Fan C, Meneguello L, Arashiro Pulschen A, Dey G, Culley S, Kilkenny M, Souza DP, Pellegrini L, de Bruin RAM, Henriques R, Snijders AP, Šarić A, Lindås A-C, Robinson NP, Baum B. 2020. The proteasome controls ESCRT-III–mediated cell division in an archaeon. Science. 369(6504).","short":"G. Tarrason Risa, F. Hurtig, S. Bray, A.E. Hafner, L. Harker-Kirschneck, P. Faull, C. Davis, D. Papatziamou, D.R. Mutavchiev, C. Fan, L. Meneguello, A. Arashiro Pulschen, G. Dey, S. Culley, M. Kilkenny, D.P. Souza, L. Pellegrini, R.A.M. de Bruin, R. Henriques, A.P. Snijders, A. Šarić, A.-C. Lindås, N.P. Robinson, B. Baum, Science 369 (2020).","apa":"Tarrason Risa, G., Hurtig, F., Bray, S., Hafner, A. E., Harker-Kirschneck, L., Faull, P., … Baum, B. (2020). The proteasome controls ESCRT-III–mediated cell division in an archaeon. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.aaz2532\">https://doi.org/10.1126/science.aaz2532</a>","ieee":"G. Tarrason Risa <i>et al.</i>, “The proteasome controls ESCRT-III–mediated cell division in an archaeon,” <i>Science</i>, vol. 369, no. 6504. American Association for the Advancement of Science, 2020.","chicago":"Tarrason Risa, Gabriel, Fredrik Hurtig, Sian Bray, Anne E. Hafner, Lena Harker-Kirschneck, Peter Faull, Colin Davis, et al. “The Proteasome Controls ESCRT-III–Mediated Cell Division in an Archaeon.” <i>Science</i>. American Association for the Advancement of Science, 2020. <a href=\"https://doi.org/10.1126/science.aaz2532\">https://doi.org/10.1126/science.aaz2532</a>."},"author":[{"first_name":"Gabriel","last_name":"Tarrason Risa","full_name":"Tarrason Risa, Gabriel"},{"full_name":"Hurtig, Fredrik","last_name":"Hurtig","first_name":"Fredrik"},{"first_name":"Sian","last_name":"Bray","full_name":"Bray, Sian"},{"first_name":"Anne E.","full_name":"Hafner, Anne E.","last_name":"Hafner"},{"first_name":"Lena","last_name":"Harker-Kirschneck","full_name":"Harker-Kirschneck, Lena"},{"first_name":"Peter","full_name":"Faull, Peter","last_name":"Faull"},{"first_name":"Colin","last_name":"Davis","full_name":"Davis, Colin"},{"first_name":"Dimitra","last_name":"Papatziamou","full_name":"Papatziamou, Dimitra"},{"last_name":"Mutavchiev","full_name":"Mutavchiev, Delyan R.","first_name":"Delyan R."},{"full_name":"Fan, Catherine","last_name":"Fan","first_name":"Catherine"},{"first_name":"Leticia","full_name":"Meneguello, Leticia","last_name":"Meneguello"},{"full_name":"Arashiro Pulschen, Andre","last_name":"Arashiro Pulschen","first_name":"Andre"},{"last_name":"Dey","full_name":"Dey, Gautam","first_name":"Gautam"},{"full_name":"Culley, Siân","last_name":"Culley","first_name":"Siân"},{"full_name":"Kilkenny, Mairi","last_name":"Kilkenny","first_name":"Mairi"},{"first_name":"Diorge P.","full_name":"Souza, Diorge P.","last_name":"Souza"},{"first_name":"Luca","full_name":"Pellegrini, Luca","last_name":"Pellegrini"},{"last_name":"de Bruin","full_name":"de Bruin, Robertus A. M.","first_name":"Robertus A. M."},{"first_name":"Ricardo","last_name":"Henriques","full_name":"Henriques, Ricardo"},{"first_name":"Ambrosius P.","full_name":"Snijders, Ambrosius P.","last_name":"Snijders"},{"id":"bf63d406-f056-11eb-b41d-f263a6566d8b","full_name":"Šarić, Anđela","last_name":"Šarić","orcid":"0000-0002-7854-2139","first_name":"Anđela"},{"first_name":"Ann-Christin","full_name":"Lindås, Ann-Christin","last_name":"Lindås"},{"first_name":"Nicholas P.","full_name":"Robinson, Nicholas P.","last_name":"Robinson"},{"first_name":"Buzz","last_name":"Baum","full_name":"Baum, Buzz"}],"keyword":["multidisciplinary"],"abstract":[{"lang":"eng","text":"Sulfolobus acidocaldarius is the closest experimentally tractable archaeal relative of eukaryotes and, despite lacking obvious cyclin-dependent kinase and cyclin homologs, has an ordered eukaryote-like cell cycle with distinct phases of DNA replication and division. Here, in exploring the mechanism of cell division in S. acidocaldarius, we identify a role for the archaeal proteasome in regulating the transition from the end of one cell cycle to the beginning of the next. Further, we identify the archaeal ESCRT-III homolog, CdvB, as a key target of the proteasome and show that its degradation triggers division by allowing constriction of the CdvB1:CdvB2 ESCRT-III division ring. These findings offer a minimal mechanism for ESCRT-III–mediated membrane remodeling and point to a conserved role for the proteasome in eukaryotic and archaeal cell cycle control."}],"date_updated":"2021-11-26T08:58:33Z","oa":1,"volume":369,"article_processing_charge":"No","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","acknowledgement":"We thank the MRC LMCB at UCL for their support; the flow cytometry STP at the Francis Crick Institute for assistance, with special thanks to S. Purewal and D. Davis; C. Bertoli for mentorship\r\nand advice; J. M. Garcia-Arcos for help early on in this project; the entire Baum lab for their input throughout the project; the Albers lab for advice and reagents, with special thanks to M. Van Wolferen and S. Albers; the members of the Wellcome consortium for archaeal cytoskeleton studies for advice and comments; and J. Löwe, S. Oliferenko, M. Balasubramanian, and D. Gerlich for discussions and advice on the manuscript. N.P.R. and S.B. would like to thank N. Rzechorzek, A. Simon, and S. Anjum for discussion and advice.","quality_controlled":"1","oa_version":"Preprint","pmid":1,"_id":"10349","extern":"1","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"year":"2020","doi":"10.1126/science.aaz2532","external_id":{"pmid":["32764038"]},"title":"The proteasome controls ESCRT-III–mediated cell division in an archaeon","main_file_link":[{"open_access":"1","url":"https://www.biorxiv.org/content/10.1101/774273v1"}],"type":"journal_article","day":"07","status":"public","intvolume":"       369","issue":"6504","publication":"Science","date_published":"2020-08-07T00:00:00Z","article_type":"original","month":"08","language":[{"iso":"eng"}],"publisher":"American Association for the Advancement of Science","scopus_import":"1","date_created":"2021-11-26T08:21:34Z"},{"doi":"10.1126/science.aaw9144","year":"2019","acknowledged_ssus":[{"_id":"ScienComp"}],"title":"Structure and conformational plasticity of the intact Thermus thermophilus V/A-type ATPase","external_id":{"isi":["000482464000043"],"pmid":["31439765"]},"isi":1,"article_number":"eaaw9144","related_material":{"link":[{"url":"https://ist.ac.at/en/news/structure-of-protein-nano-turbine-revealed/","relation":"press_release","description":"News on IST Website"}]},"citation":{"ieee":"L. Zhou and L. A. Sazanov, “Structure and conformational plasticity of the intact Thermus thermophilus V/A-type ATPase,” <i>Science</i>, vol. 365, no. 6455. AAAS, 2019.","apa":"Zhou, L., &#38; Sazanov, L. A. (2019). Structure and conformational plasticity of the intact Thermus thermophilus V/A-type ATPase. <i>Science</i>. AAAS. <a href=\"https://doi.org/10.1126/science.aaw9144\">https://doi.org/10.1126/science.aaw9144</a>","chicago":"Zhou, Long, and Leonid A Sazanov. “Structure and Conformational Plasticity of the Intact Thermus Thermophilus V/A-Type ATPase.” <i>Science</i>. AAAS, 2019. <a href=\"https://doi.org/10.1126/science.aaw9144\">https://doi.org/10.1126/science.aaw9144</a>.","mla":"Zhou, Long, and Leonid A. Sazanov. “Structure and Conformational Plasticity of the Intact Thermus Thermophilus V/A-Type ATPase.” <i>Science</i>, vol. 365, no. 6455, eaaw9144, AAAS, 2019, doi:<a href=\"https://doi.org/10.1126/science.aaw9144\">10.1126/science.aaw9144</a>.","ama":"Zhou L, Sazanov LA. Structure and conformational plasticity of the intact Thermus thermophilus V/A-type ATPase. <i>Science</i>. 2019;365(6455). doi:<a href=\"https://doi.org/10.1126/science.aaw9144\">10.1126/science.aaw9144</a>","ista":"Zhou L, Sazanov LA. 2019. Structure and conformational plasticity of the intact Thermus thermophilus V/A-type ATPase. Science. 365(6455), eaaw9144.","short":"L. Zhou, L.A. Sazanov, Science 365 (2019)."},"publication_status":"published","abstract":[{"lang":"eng","text":"V (vacuolar)/A (archaeal)-type adenosine triphosphatases (ATPases), found in archaeaand eubacteria, couple ATP hydrolysis or synthesis to proton translocation across theplasma membrane using the rotary-catalysis mechanism. They belong to the V-typeATPase family, which differs from the mitochondrial/chloroplast F-type ATP synthasesin overall architecture. We solved cryo–electron microscopy structures of the intactThermus thermophilusV/A-ATPase, reconstituted into lipid nanodiscs, in three rotationalstates and two substates. These structures indicate substantial flexibility betweenV1and Voin a working enzyme, which results from mechanical competition between centralshaft rotation and resistance from the peripheral stalks. We also describedetails of adenosine diphosphate inhibition release, V1-Votorque transmission, andproton translocation, which are relevant for the entire V-type ATPase family."}],"author":[{"orcid":"0000-0002-1864-8951","last_name":"Zhou","full_name":"Zhou, Long","first_name":"Long","id":"3E751364-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Leonid A","full_name":"Sazanov, Leonid A","last_name":"Sazanov","orcid":"0000-0002-0977-7989","id":"338D39FE-F248-11E8-B48F-1D18A9856A87"}],"article_processing_charge":"No","volume":365,"date_updated":"2023-08-29T07:52:02Z","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"pmid":1,"_id":"6859","quality_controlled":"1","oa_version":"None","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","month":"08","date_published":"2019-08-23T00:00:00Z","scopus_import":"1","publisher":"AAAS","language":[{"iso":"eng"}],"department":[{"_id":"LeSa"}],"date_created":"2019-09-07T19:04:45Z","day":"23","type":"journal_article","intvolume":"       365","status":"public","publication":"Science","issue":"6455"},{"language":[{"iso":"eng"}],"title":"Spatial control of heavy-fermion superconductivity in CeIrIn5","publisher":"AAAS","article_type":"original","date_published":"2019-10-11T00:00:00Z","month":"10","year":"2019","doi":"10.1126/science.aao6640","date_created":"2019-11-19T13:55:58Z","author":[{"last_name":"Bachmann","full_name":"Bachmann, Maja D.","first_name":"Maja D."},{"first_name":"G. M.","last_name":"Ferguson","full_name":"Ferguson, G. M."},{"first_name":"Florian","last_name":"Theuss","full_name":"Theuss, Florian"},{"first_name":"Tobias","full_name":"Meng, Tobias","last_name":"Meng"},{"last_name":"Putzke","full_name":"Putzke, Carsten","first_name":"Carsten"},{"first_name":"Toni","last_name":"Helm","full_name":"Helm, Toni"},{"last_name":"Shirer","full_name":"Shirer, K. R.","first_name":"K. R."},{"first_name":"You-Sheng","last_name":"Li","full_name":"Li, You-Sheng"},{"first_name":"Kimberly A","orcid":"0000-0001-9760-3147","last_name":"Modic","full_name":"Modic, Kimberly A","id":"13C26AC0-EB69-11E9-87C6-5F3BE6697425"},{"full_name":"Nicklas, Michael","last_name":"Nicklas","first_name":"Michael"},{"full_name":"König, Markus","last_name":"König","first_name":"Markus"},{"first_name":"D.","last_name":"Low","full_name":"Low, D."},{"last_name":"Ghosh","full_name":"Ghosh, Sayak","first_name":"Sayak"},{"first_name":"Andrew P.","full_name":"Mackenzie, Andrew P.","last_name":"Mackenzie"},{"first_name":"Frank","full_name":"Arnold, Frank","last_name":"Arnold"},{"full_name":"Hassinger, Elena","last_name":"Hassinger","first_name":"Elena"},{"full_name":"McDonald, Ross D.","last_name":"McDonald","first_name":"Ross D."},{"first_name":"Laurel E.","last_name":"Winter","full_name":"Winter, Laurel E."},{"first_name":"Eric D.","last_name":"Bauer","full_name":"Bauer, Eric D."},{"first_name":"Filip","full_name":"Ronning, Filip","last_name":"Ronning"},{"first_name":"B. J.","full_name":"Ramshaw, B. J.","last_name":"Ramshaw"},{"last_name":"Nowack","full_name":"Nowack, Katja C.","first_name":"Katja C."},{"last_name":"Moll","full_name":"Moll, Philip J. W.","first_name":"Philip J. W."}],"status":"public","abstract":[{"text":"Although crystals of strongly correlated metals exhibit a diverse set of electronic ground states, few approaches exist for spatially modulating their properties. In this study, we demonstrate disorder-free control, on the micrometer scale, over the superconducting state in samples of the heavy-fermion superconductor CeIrIn5. We pattern crystals by focused ion beam milling to tailor the boundary conditions for the elastic deformation upon thermal contraction during cooling. The resulting nonuniform strain fields induce complex patterns of superconductivity, owing to the strong dependence of the transition temperature on the strength and direction of strain. These results showcase a generic approach to manipulating electronic order on micrometer length scales in strongly correlated matter without compromising the cleanliness, stoichiometry, or mean free path.","lang":"eng"}],"intvolume":"       366","type":"journal_article","citation":{"ista":"Bachmann MD, Ferguson GM, Theuss F, Meng T, Putzke C, Helm T, Shirer KR, Li Y-S, Modic KA, Nicklas M, König M, Low D, Ghosh S, Mackenzie AP, Arnold F, Hassinger E, McDonald RD, Winter LE, Bauer ED, Ronning F, Ramshaw BJ, Nowack KC, Moll PJW. 2019. Spatial control of heavy-fermion superconductivity in CeIrIn5. Science. 366(6462), 221–226.","short":"M.D. Bachmann, G.M. Ferguson, F. Theuss, T. Meng, C. Putzke, T. Helm, K.R. Shirer, Y.-S. Li, K.A. Modic, M. Nicklas, M. König, D. Low, S. Ghosh, A.P. Mackenzie, F. Arnold, E. Hassinger, R.D. McDonald, L.E. Winter, E.D. Bauer, F. Ronning, B.J. Ramshaw, K.C. Nowack, P.J.W. Moll, Science 366 (2019) 221–226.","mla":"Bachmann, Maja D., et al. “Spatial Control of Heavy-Fermion Superconductivity in CeIrIn5.” <i>Science</i>, vol. 366, no. 6462, AAAS, 2019, pp. 221–26, doi:<a href=\"https://doi.org/10.1126/science.aao6640\">10.1126/science.aao6640</a>.","ama":"Bachmann MD, Ferguson GM, Theuss F, et al. Spatial control of heavy-fermion superconductivity in CeIrIn5. <i>Science</i>. 2019;366(6462):221-226. doi:<a href=\"https://doi.org/10.1126/science.aao6640\">10.1126/science.aao6640</a>","chicago":"Bachmann, Maja D., G. M. Ferguson, Florian Theuss, Tobias Meng, Carsten Putzke, Toni Helm, K. R. Shirer, et al. “Spatial Control of Heavy-Fermion Superconductivity in CeIrIn5.” <i>Science</i>. AAAS, 2019. <a href=\"https://doi.org/10.1126/science.aao6640\">https://doi.org/10.1126/science.aao6640</a>.","ieee":"M. D. Bachmann <i>et al.</i>, “Spatial control of heavy-fermion superconductivity in CeIrIn5,” <i>Science</i>, vol. 366, no. 6462. AAAS, pp. 221–226, 2019.","apa":"Bachmann, M. D., Ferguson, G. M., Theuss, F., Meng, T., Putzke, C., Helm, T., … Moll, P. J. W. (2019). Spatial control of heavy-fermion superconductivity in CeIrIn5. <i>Science</i>. AAAS. <a href=\"https://doi.org/10.1126/science.aao6640\">https://doi.org/10.1126/science.aao6640</a>"},"day":"11","publication_status":"published","quality_controlled":"1","oa_version":"None","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"extern":"1","_id":"7082","page":"221-226","article_processing_charge":"No","date_updated":"2021-01-12T08:11:46Z","volume":366,"publication":"Science","issue":"6462"},{"isi":1,"related_material":{"record":[{"status":"public","relation":"popular_science","id":"6062"},{"status":"public","relation":"dissertation_contains","id":"11932"}],"link":[{"url":"https://ist.ac.at/en/news/grid-cells-create-treasure-map-in-rat-brain/","relation":"press_release","description":"News on IST Homepage"}]},"ddc":["570"],"year":"2019","doi":"10.1126/science.aav4837","ec_funded":1,"title":"The entorhinal cognitive map is attracted to goals","external_id":{"isi":["000462738000034"]},"date_updated":"2024-03-25T23:30:09Z","volume":363,"oa":1,"article_processing_charge":"No","_id":"6194","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","oa_version":"Submitted Version","project":[{"name":"Memory-related information processing in neuronal circuits of the hippocampus and entorhinal cortex","_id":"257A4776-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","grant_number":"281511"},{"call_identifier":"H2020","name":"International IST Doctoral Program","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","grant_number":"665385"}],"quality_controlled":"1","publication_status":"published","citation":{"chicago":"Boccara, Charlotte N., Michele Nardin, Federico Stella, Joseph O’Neill, and Jozsef L Csicsvari. “The Entorhinal Cognitive Map Is Attracted to Goals.” <i>Science</i>. American Association for the Advancement of Science, 2019. <a href=\"https://doi.org/10.1126/science.aav4837\">https://doi.org/10.1126/science.aav4837</a>.","apa":"Boccara, C. N., Nardin, M., Stella, F., O’Neill, J., &#38; Csicsvari, J. L. (2019). The entorhinal cognitive map is attracted to goals. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.aav4837\">https://doi.org/10.1126/science.aav4837</a>","ieee":"C. N. Boccara, M. Nardin, F. Stella, J. O’Neill, and J. L. Csicsvari, “The entorhinal cognitive map is attracted to goals,” <i>Science</i>, vol. 363, no. 6434. American Association for the Advancement of Science, pp. 1443–1447, 2019.","ista":"Boccara CN, Nardin M, Stella F, O’Neill J, Csicsvari JL. 2019. The entorhinal cognitive map is attracted to goals. Science. 363(6434), 1443–1447.","short":"C.N. Boccara, M. Nardin, F. Stella, J. O’Neill, J.L. Csicsvari, Science 363 (2019) 1443–1447.","mla":"Boccara, Charlotte N., et al. “The Entorhinal Cognitive Map Is Attracted to Goals.” <i>Science</i>, vol. 363, no. 6434, American Association for the Advancement of Science, 2019, pp. 1443–47, doi:<a href=\"https://doi.org/10.1126/science.aav4837\">10.1126/science.aav4837</a>.","ama":"Boccara CN, Nardin M, Stella F, O’Neill J, Csicsvari JL. The entorhinal cognitive map is attracted to goals. <i>Science</i>. 2019;363(6434):1443-1447. doi:<a href=\"https://doi.org/10.1126/science.aav4837\">10.1126/science.aav4837</a>"},"abstract":[{"lang":"eng","text":"Grid cells with their rigid hexagonal firing fields are thought to provide an invariant metric to the hippocampal cognitive map, yet environmental geometrical features have recently been shown to distort the grid structure. Given that the hippocampal role goes beyond space, we tested the influence of nonspatial information on the grid organization. We trained rats to daily learn three new reward locations on a cheeseboard maze while recording from the medial entorhinal cortex and the hippocampal CA1 region. Many grid fields moved toward goal location, leading to long-lasting deformations of the entorhinal map. Therefore, distortions in the grid structure contribute to goal representation during both learning and recall, which demonstrates that grid cells participate in mnemonic coding and do not merely provide a simple metric of space."}],"author":[{"full_name":"Boccara, Charlotte N.","last_name":"Boccara","orcid":"0000-0001-7237-5109","first_name":"Charlotte N.","id":"3FC06552-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0001-8849-6570","full_name":"Nardin, Michele","last_name":"Nardin","first_name":"Michele","id":"30BD0376-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Stella","full_name":"Stella, Federico","orcid":"0000-0001-9439-3148","first_name":"Federico","id":"39AF1E74-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Joseph","full_name":"O'Neill, Joseph","last_name":"O'Neill","id":"426376DC-F248-11E8-B48F-1D18A9856A87"},{"id":"3FA14672-F248-11E8-B48F-1D18A9856A87","full_name":"Csicsvari, Jozsef L","last_name":"Csicsvari","orcid":"0000-0002-5193-4036","first_name":"Jozsef L"}],"has_accepted_license":"1","department":[{"_id":"JoCs"}],"date_created":"2019-04-04T08:39:30Z","file":[{"file_id":"7826","creator":"dernst","content_type":"application/pdf","relation":"main_file","date_updated":"2020-07-14T12:47:23Z","access_level":"open_access","date_created":"2020-05-14T09:11:10Z","checksum":"5e6b16742cde10a560cfaf2130764da1","file_name":"2019_Science_Boccara.pdf","file_size":9045923}],"month":"03","article_type":"original","date_published":"2019-03-29T00:00:00Z","publisher":"American Association for the Advancement of Science","scopus_import":"1","language":[{"iso":"eng"}],"issue":"6434","publication":"Science","file_date_updated":"2020-07-14T12:47:23Z","page":"1443-1447","day":"29","type":"journal_article","intvolume":"       363","status":"public"},{"publisher":"AAAS","scopus_import":"1","language":[{"iso":"eng"}],"month":"05","date_published":"2019-05-10T00:00:00Z","article_type":"original","date_created":"2019-05-14T13:07:47Z","department":[{"_id":"SiHi"}],"intvolume":"       364","status":"public","day":"10","type":"journal_article","issue":"6440","publication":"Science","title":"Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex","external_id":{"pmid":["31073041"],"isi":["000467631800034"]},"year":"2019","doi":"10.1126/science.aav2522","ec_funded":1,"related_material":{"link":[{"description":"News on IST Homepage","relation":"press_release","url":"https://ist.ac.at/en/news/how-to-generate-a-brain-of-correct-size-and-composition/"}]},"article_number":"eaav2522","isi":1,"main_file_link":[{"open_access":"1","url":"https://orbi.uliege.be/bitstream/2268/239604/1/Telley_Agirman_Science2019.pdf"}],"abstract":[{"lang":"eng","text":"During corticogenesis, distinct subtypes of neurons are sequentially born from ventricular zone progenitors. How these cells are molecularly temporally patterned is poorly understood. We used single-cell RNA sequencing at high temporal resolution to trace the lineage of the molecular identities of successive generations of apical progenitors (APs) and their daughter neurons in mouse embryos. We identified a core set of evolutionarily conserved, temporally patterned genes that drive APs from internally driven to more exteroceptive states. We found that the Polycomb repressor complex 2 (PRC2) epigenetically regulates AP temporal progression. Embryonic age–dependent AP molecular states are transmitted to their progeny as successive ground states, onto which essentially conserved early postmitotic differentiation programs are applied, and are complemented by later-occurring environment-dependent signals. Thus, epigenetically regulated temporal molecular birthmarks present in progenitors act in their postmitotic progeny to seed adult neuronal diversity."}],"author":[{"full_name":"Telley, L","last_name":"Telley","first_name":"L"},{"first_name":"G","last_name":"Agirman","full_name":"Agirman, G"},{"first_name":"J","full_name":"Prados, J","last_name":"Prados"},{"orcid":"0000-0002-3183-8207","last_name":"Amberg","full_name":"Amberg, Nicole","first_name":"Nicole","id":"4CD6AAC6-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Fièvre, S","last_name":"Fièvre","first_name":"S"},{"last_name":"Oberst","full_name":"Oberst, P","first_name":"P"},{"first_name":"G","full_name":"Bartolini, G","last_name":"Bartolini"},{"first_name":"I","last_name":"Vitali","full_name":"Vitali, I"},{"first_name":"C","full_name":"Cadilhac, C","last_name":"Cadilhac"},{"first_name":"Simon","orcid":"0000-0003-2279-1061","last_name":"Hippenmeyer","full_name":"Hippenmeyer, Simon","id":"37B36620-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Nguyen","full_name":"Nguyen, L","first_name":"L"},{"full_name":"Dayer, A","last_name":"Dayer","first_name":"A"},{"first_name":"D","full_name":"Jabaudon, D","last_name":"Jabaudon"}],"publication_status":"published","citation":{"ieee":"L. Telley <i>et al.</i>, “Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex,” <i>Science</i>, vol. 364, no. 6440. AAAS, 2019.","apa":"Telley, L., Agirman, G., Prados, J., Amberg, N., Fièvre, S., Oberst, P., … Jabaudon, D. (2019). Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex. <i>Science</i>. AAAS. <a href=\"https://doi.org/10.1126/science.aav2522\">https://doi.org/10.1126/science.aav2522</a>","chicago":"Telley, L, G Agirman, J Prados, Nicole Amberg, S Fièvre, P Oberst, G Bartolini, et al. “Temporal Patterning of Apical Progenitors and Their Daughter Neurons in the Developing Neocortex.” <i>Science</i>. AAAS, 2019. <a href=\"https://doi.org/10.1126/science.aav2522\">https://doi.org/10.1126/science.aav2522</a>.","mla":"Telley, L., et al. “Temporal Patterning of Apical Progenitors and Their Daughter Neurons in the Developing Neocortex.” <i>Science</i>, vol. 364, no. 6440, eaav2522, AAAS, 2019, doi:<a href=\"https://doi.org/10.1126/science.aav2522\">10.1126/science.aav2522</a>.","ama":"Telley L, Agirman G, Prados J, et al. Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex. <i>Science</i>. 2019;364(6440). doi:<a href=\"https://doi.org/10.1126/science.aav2522\">10.1126/science.aav2522</a>","short":"L. Telley, G. Agirman, J. Prados, N. Amberg, S. Fièvre, P. Oberst, G. Bartolini, I. Vitali, C. Cadilhac, S. Hippenmeyer, L. Nguyen, A. Dayer, D. Jabaudon, Science 364 (2019).","ista":"Telley L, Agirman G, Prados J, Amberg N, Fièvre S, Oberst P, Bartolini G, Vitali I, Cadilhac C, Hippenmeyer S, Nguyen L, Dayer A, Jabaudon D. 2019. Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex. Science. 364(6440), eaav2522."},"_id":"6455","pmid":1,"publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","project":[{"grant_number":"725780","call_identifier":"H2020","name":"Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development","_id":"260018B0-B435-11E9-9278-68D0E5697425"},{"name":"Role of Eed in neural stem cell lineage progression","_id":"268F8446-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","grant_number":"T0101031"}],"quality_controlled":"1","oa_version":"Published Version","oa":1,"volume":364,"date_updated":"2023-09-05T11:51:09Z","article_processing_charge":"No"},{"external_id":{"pmid":["31857492"],"arxiv":["1907.00261"]},"title":"Intrinsic quantized anomalous Hall effect in a moiré heterostructure","doi":"10.1126/science.aay5533","year":"2019","related_material":{"record":[{"status":"public","relation":"other","id":"10697"},{"relation":"other","id":"10698","status":"public"},{"status":"public","id":"10699","relation":"other"}]},"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1907.00261"}],"author":[{"last_name":"Serlin","full_name":"Serlin, M.","first_name":"M."},{"last_name":"Tschirhart","full_name":"Tschirhart, C. L.","first_name":"C. L."},{"first_name":"Hryhoriy","orcid":"0000-0001-8223-8896","full_name":"Polshyn, Hryhoriy","last_name":"Polshyn","id":"edfc7cb1-526e-11ec-b05a-e6ecc27e4e48"},{"full_name":"Zhang, Y.","last_name":"Zhang","first_name":"Y."},{"first_name":"J.","full_name":"Zhu, J.","last_name":"Zhu"},{"last_name":"Watanabe","full_name":"Watanabe, K.","first_name":"K."},{"first_name":"T.","full_name":"Taniguchi, T.","last_name":"Taniguchi"},{"first_name":"L.","full_name":"Balents, L.","last_name":"Balents"},{"full_name":"Young, A. F.","last_name":"Young","first_name":"A. F."}],"keyword":["multidisciplinary"],"abstract":[{"lang":"eng","text":"The quantum anomalous Hall (QAH) effect combines topology and magnetism to produce precisely quantized Hall resistance at zero magnetic field. We report the observation of a QAH effect in twisted bilayer graphene aligned to hexagonal boron nitride. The effect is driven by intrinsic strong interactions, which polarize the electrons into a single spin- and valley-resolved moiré miniband with Chern number C = 1. In contrast to magnetically doped systems, the measured transport energy gap is larger than the Curie temperature for magnetic ordering, and quantization to within 0.1% of the von Klitzing constant persists to temperatures of several kelvin at zero magnetic field. Electrical currents as small as 1 nanoampere controllably switch the magnetic order between states of opposite polarization, forming an electrically rewritable magnetic memory."}],"citation":{"mla":"Serlin, M., et al. “Intrinsic Quantized Anomalous Hall Effect in a Moiré Heterostructure.” <i>Science</i>, vol. 367, no. 6480, American Association for the Advancement of Science, 2019, pp. 900–03, doi:<a href=\"https://doi.org/10.1126/science.aay5533\">10.1126/science.aay5533</a>.","ama":"Serlin M, Tschirhart CL, Polshyn H, et al. Intrinsic quantized anomalous Hall effect in a moiré heterostructure. <i>Science</i>. 2019;367(6480):900-903. doi:<a href=\"https://doi.org/10.1126/science.aay5533\">10.1126/science.aay5533</a>","short":"M. Serlin, C.L. Tschirhart, H. Polshyn, Y. Zhang, J. Zhu, K. Watanabe, T. Taniguchi, L. Balents, A.F. Young, Science 367 (2019) 900–903.","ista":"Serlin M, Tschirhart CL, Polshyn H, Zhang Y, Zhu J, Watanabe K, Taniguchi T, Balents L, Young AF. 2019. Intrinsic quantized anomalous Hall effect in a moiré heterostructure. Science. 367(6480), 900–903.","apa":"Serlin, M., Tschirhart, C. L., Polshyn, H., Zhang, Y., Zhu, J., Watanabe, K., … Young, A. F. (2019). Intrinsic quantized anomalous Hall effect in a moiré heterostructure. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.aay5533\">https://doi.org/10.1126/science.aay5533</a>","ieee":"M. Serlin <i>et al.</i>, “Intrinsic quantized anomalous Hall effect in a moiré heterostructure,” <i>Science</i>, vol. 367, no. 6480. American Association for the Advancement of Science, pp. 900–903, 2019.","chicago":"Serlin, M., C. L. Tschirhart, Hryhoriy Polshyn, Y. Zhang, J. Zhu, K. Watanabe, T. Taniguchi, L. Balents, and A. F. Young. “Intrinsic Quantized Anomalous Hall Effect in a Moiré Heterostructure.” <i>Science</i>. American Association for the Advancement of Science, 2019. <a href=\"https://doi.org/10.1126/science.aay5533\">https://doi.org/10.1126/science.aay5533</a>."},"publication_status":"published","oa_version":"Preprint","quality_controlled":"1","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","acknowledgement":"The authors acknowledge discussions with A. Macdonald, Y. Saito, and M. Zaletel.","extern":"1","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"pmid":1,"_id":"10619","article_processing_charge":"No","oa":1,"volume":367,"date_updated":"2023-02-21T16:00:09Z","arxiv":1,"language":[{"iso":"eng"}],"scopus_import":"1","publisher":"American Association for the Advancement of Science","article_type":"original","date_published":"2019-12-19T00:00:00Z","month":"12","date_created":"2022-01-13T14:21:32Z","status":"public","intvolume":"       367","type":"journal_article","day":"19","page":"900-903","publication":"Science","issue":"6480"},{"publisher":"American Association for the Advancement of Science (AAAS)","scopus_import":"1","language":[{"iso":"eng"}],"month":"01","date_published":"2019-01-24T00:00:00Z","article_type":"original","date_created":"2022-01-14T12:14:58Z","intvolume":"       363","status":"public","day":"24","type":"journal_article","issue":"6431","publication":"Science","page":"1059-1064","title":"Tuning superconductivity in twisted bilayer graphene","external_id":{"arxiv":["1808.07865"],"pmid":["30679385 "]},"doi":"10.1126/science.aav1910","year":"2019","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1808.07865"}],"abstract":[{"lang":"eng","text":"The discovery of superconductivity and exotic insulating phases in twisted bilayer graphene has established this material as a model system of strongly correlated electrons. To achieve superconductivity, the two layers of graphene need to be at a very precise angle with respect to each other. Yankowitz et al. now show that another experimental knob, hydrostatic pressure, can be used to tune the phase diagram of twisted bilayer graphene (see the Perspective by Feldman). Applying pressure increased the coupling between the layers, which shifted the superconducting transition to higher angles and somewhat higher temperatures."}],"keyword":["multidisciplinary"],"author":[{"full_name":"Yankowitz, Matthew","last_name":"Yankowitz","first_name":"Matthew"},{"first_name":"Shaowen","last_name":"Chen","full_name":"Chen, Shaowen"},{"orcid":"0000-0001-8223-8896","full_name":"Polshyn, Hryhoriy","last_name":"Polshyn","first_name":"Hryhoriy","id":"edfc7cb1-526e-11ec-b05a-e6ecc27e4e48"},{"last_name":"Zhang","full_name":"Zhang, Yuxuan","first_name":"Yuxuan"},{"full_name":"Watanabe, K.","last_name":"Watanabe","first_name":"K."},{"last_name":"Taniguchi","full_name":"Taniguchi, T.","first_name":"T."},{"first_name":"David","full_name":"Graf, David","last_name":"Graf"},{"last_name":"Young","full_name":"Young, Andrea F.","first_name":"Andrea F."},{"first_name":"Cory R.","last_name":"Dean","full_name":"Dean, Cory R."}],"publication_status":"published","citation":{"ama":"Yankowitz M, Chen S, Polshyn H, et al. Tuning superconductivity in twisted bilayer graphene. <i>Science</i>. 2019;363(6431):1059-1064. doi:<a href=\"https://doi.org/10.1126/science.aav1910\">10.1126/science.aav1910</a>","mla":"Yankowitz, Matthew, et al. “Tuning Superconductivity in Twisted Bilayer Graphene.” <i>Science</i>, vol. 363, no. 6431, American Association for the Advancement of Science (AAAS), 2019, pp. 1059–64, doi:<a href=\"https://doi.org/10.1126/science.aav1910\">10.1126/science.aav1910</a>.","short":"M. Yankowitz, S. Chen, H. Polshyn, Y. Zhang, K. Watanabe, T. Taniguchi, D. Graf, A.F. Young, C.R. Dean, Science 363 (2019) 1059–1064.","ista":"Yankowitz M, Chen S, Polshyn H, Zhang Y, Watanabe K, Taniguchi T, Graf D, Young AF, Dean CR. 2019. Tuning superconductivity in twisted bilayer graphene. Science. 363(6431), 1059–1064.","apa":"Yankowitz, M., Chen, S., Polshyn, H., Zhang, Y., Watanabe, K., Taniguchi, T., … Dean, C. R. (2019). Tuning superconductivity in twisted bilayer graphene. <i>Science</i>. American Association for the Advancement of Science (AAAS). <a href=\"https://doi.org/10.1126/science.aav1910\">https://doi.org/10.1126/science.aav1910</a>","ieee":"M. Yankowitz <i>et al.</i>, “Tuning superconductivity in twisted bilayer graphene,” <i>Science</i>, vol. 363, no. 6431. American Association for the Advancement of Science (AAAS), pp. 1059–1064, 2019.","chicago":"Yankowitz, Matthew, Shaowen Chen, Hryhoriy Polshyn, Yuxuan Zhang, K. Watanabe, T. Taniguchi, David Graf, Andrea F. Young, and Cory R. Dean. “Tuning Superconductivity in Twisted Bilayer Graphene.” <i>Science</i>. American Association for the Advancement of Science (AAAS), 2019. <a href=\"https://doi.org/10.1126/science.aav1910\">https://doi.org/10.1126/science.aav1910</a>."},"pmid":1,"_id":"10625","extern":"1","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"acknowledgement":"We thank J. Zhu and H. Zhou for experimental assistance and D. Shahar, A. Millis, O. Vafek, M. Zaletel, L. Balents, C. Xu, A. Bernevig, L. Fu, M. Koshino, and P. Moon for helpful discussions.","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","quality_controlled":"1","oa_version":"Preprint","arxiv":1,"oa":1,"date_updated":"2022-01-14T13:48:32Z","volume":363,"article_processing_charge":"No"},{"date_created":"2019-11-19T13:03:16Z","language":[{"iso":"eng"}],"title":"Scale-invariant magnetoresistance in a cuprate superconductor","publisher":"AAAS","article_type":"original","date_published":"2018-08-03T00:00:00Z","month":"08","doi":"10.1126/science.aan3178","year":"2018","oa_version":"None","quality_controlled":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","extern":"1","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"_id":"7060","article_processing_charge":"No","page":"479-481","date_updated":"2021-01-12T08:11:37Z","volume":361,"publication":"Science","issue":"6401","status":"public","author":[{"first_name":"P.","full_name":"Giraldo-Gallo, P.","last_name":"Giraldo-Gallo"},{"last_name":"Galvis","full_name":"Galvis, J. A.","first_name":"J. A."},{"first_name":"Z.","full_name":"Stegen, Z.","last_name":"Stegen"},{"id":"13C26AC0-EB69-11E9-87C6-5F3BE6697425","first_name":"Kimberly A","orcid":"0000-0001-9760-3147","full_name":"Modic, Kimberly A","last_name":"Modic"},{"first_name":"F. F.","last_name":"Balakirev","full_name":"Balakirev, F. F."},{"first_name":"J. B.","full_name":"Betts, J. B.","last_name":"Betts"},{"last_name":"Lian","full_name":"Lian, X.","first_name":"X."},{"first_name":"C.","full_name":"Moir, C.","last_name":"Moir"},{"last_name":"Riggs","full_name":"Riggs, S. C.","first_name":"S. C."},{"full_name":"Wu, J.","last_name":"Wu","first_name":"J."},{"first_name":"A. T.","full_name":"Bollinger, A. T.","last_name":"Bollinger"},{"last_name":"He","full_name":"He, X.","first_name":"X."},{"full_name":"Božović, I.","last_name":"Božović","first_name":"I."},{"full_name":"Ramshaw, B. J.","last_name":"Ramshaw","first_name":"B. J."},{"first_name":"R. D.","full_name":"McDonald, R. D.","last_name":"McDonald"},{"last_name":"Boebinger","full_name":"Boebinger, G. S.","first_name":"G. S."},{"first_name":"A.","full_name":"Shekhter, A.","last_name":"Shekhter"}],"intvolume":"       361","abstract":[{"text":"The anomalous metallic state in the high-temperature superconducting cuprates is masked by superconductivity near a quantum critical point. Applying high magnetic fields to suppress superconductivity has enabled detailed studies of the normal state, yet the direct effect of strong magnetic fields on the metallic state is poorly understood. We report the high-field magnetoresistance of thin-film La2–xSrxCuO4 cuprate in the vicinity of the critical doping, 0.161 ≤ p ≤ 0.190. We find that the metallic state exposed by suppressing superconductivity is characterized by magnetoresistance that is linear in magnetic fields up to 80 tesla. The magnitude of the linear-in-field resistivity mirrors the magnitude and doping evolution of the well-known linear-in-temperature resistivity that has been associated with quantum criticality in high-temperature superconductors.","lang":"eng"}],"type":"journal_article","citation":{"ama":"Giraldo-Gallo P, Galvis JA, Stegen Z, et al. Scale-invariant magnetoresistance in a cuprate superconductor. <i>Science</i>. 2018;361(6401):479-481. doi:<a href=\"https://doi.org/10.1126/science.aan3178\">10.1126/science.aan3178</a>","mla":"Giraldo-Gallo, P., et al. “Scale-Invariant Magnetoresistance in a Cuprate Superconductor.” <i>Science</i>, vol. 361, no. 6401, AAAS, 2018, pp. 479–81, doi:<a href=\"https://doi.org/10.1126/science.aan3178\">10.1126/science.aan3178</a>.","ista":"Giraldo-Gallo P, Galvis JA, Stegen Z, Modic KA, Balakirev FF, Betts JB, Lian X, Moir C, Riggs SC, Wu J, Bollinger AT, He X, Božović I, Ramshaw BJ, McDonald RD, Boebinger GS, Shekhter A. 2018. Scale-invariant magnetoresistance in a cuprate superconductor. Science. 361(6401), 479–481.","short":"P. Giraldo-Gallo, J.A. Galvis, Z. Stegen, K.A. Modic, F.F. Balakirev, J.B. Betts, X. Lian, C. Moir, S.C. Riggs, J. Wu, A.T. Bollinger, X. He, I. Božović, B.J. Ramshaw, R.D. McDonald, G.S. Boebinger, A. Shekhter, Science 361 (2018) 479–481.","apa":"Giraldo-Gallo, P., Galvis, J. A., Stegen, Z., Modic, K. A., Balakirev, F. F., Betts, J. B., … Shekhter, A. (2018). Scale-invariant magnetoresistance in a cuprate superconductor. <i>Science</i>. AAAS. <a href=\"https://doi.org/10.1126/science.aan3178\">https://doi.org/10.1126/science.aan3178</a>","ieee":"P. Giraldo-Gallo <i>et al.</i>, “Scale-invariant magnetoresistance in a cuprate superconductor,” <i>Science</i>, vol. 361, no. 6401. AAAS, pp. 479–481, 2018.","chicago":"Giraldo-Gallo, P., J. A. Galvis, Z. Stegen, Kimberly A Modic, F. F. Balakirev, J. B. Betts, X. Lian, et al. “Scale-Invariant Magnetoresistance in a Cuprate Superconductor.” <i>Science</i>. AAAS, 2018. <a href=\"https://doi.org/10.1126/science.aan3178\">https://doi.org/10.1126/science.aan3178</a>."},"day":"03","publication_status":"published"}]