---
_id: '7721'
abstract:
- lang: eng
  text: 'The availability of genome-wide genetic data on hundreds of thousands of
    people has led to an equally rapid growth in methodologies available to analyse
    these data. While the motivation for undertaking genome-wide association studies
    (GWAS) is identification of genetic markers associated with complex traits, once
    generated these data can be used for many other analyses. GWAS have demonstrated
    that complex traits exhibit a highly polygenic genetic architecture, often with
    shared genetic risk factors across traits. New methods to analyse data from GWAS
    are increasingly being used to address a diverse set of questions about the aetiology
    of complex traits and diseases, including psychiatric disorders. Here, we give
    an overview of some of these methods and present examples of how they have contributed
    to our understanding of psychiatric disorders. We consider: (i) estimation of
    the extent of genetic influence on traits, (ii) uncovering of shared genetic control
    between traits, (iii) predictions of genetic risk for individuals, (iv) uncovering
    of causal relationships between traits, (v) identifying causal single-nucleotide
    polymorphisms and genes or (vi) the detection of genetic heterogeneity. This classification
    helps organise the large number of recently developed methods, although some could
    be placed in more than one category. While some methods require GWAS data on individual
    people, others simply use GWAS summary statistics data, allowing novel well-powered
    analyses to be conducted at a low computational burden.'
article_processing_charge: No
article_type: original
author:
- first_name: R. M.
  full_name: Maier, R. M.
  last_name: Maier
- first_name: P. M.
  full_name: Visscher, P. M.
  last_name: Visscher
- first_name: Matthew Richard
  full_name: Robinson, Matthew Richard
  id: E5D42276-F5DA-11E9-8E24-6303E6697425
  last_name: Robinson
  orcid: 0000-0001-8982-8813
- first_name: N. R.
  full_name: Wray, N. R.
  last_name: Wray
citation:
  ama: 'Maier RM, Visscher PM, Robinson MR, Wray NR. Embracing polygenicity: A review
    of methods and tools for psychiatric genetics research. <i>Psychological Medicine</i>.
    2018;48(7):1055-1067. doi:<a href="https://doi.org/10.1017/s0033291717002318">10.1017/s0033291717002318</a>'
  apa: 'Maier, R. M., Visscher, P. M., Robinson, M. R., &#38; Wray, N. R. (2018).
    Embracing polygenicity: A review of methods and tools for psychiatric genetics
    research. <i>Psychological Medicine</i>. Cambridge University Press. <a href="https://doi.org/10.1017/s0033291717002318">https://doi.org/10.1017/s0033291717002318</a>'
  chicago: 'Maier, R. M., P. M. Visscher, Matthew Richard Robinson, and N. R. Wray.
    “Embracing Polygenicity: A Review of Methods and Tools for Psychiatric Genetics
    Research.” <i>Psychological Medicine</i>. Cambridge University Press, 2018. <a
    href="https://doi.org/10.1017/s0033291717002318">https://doi.org/10.1017/s0033291717002318</a>.'
  ieee: 'R. M. Maier, P. M. Visscher, M. R. Robinson, and N. R. Wray, “Embracing polygenicity:
    A review of methods and tools for psychiatric genetics research,” <i>Psychological
    Medicine</i>, vol. 48, no. 7. Cambridge University Press, pp. 1055–1067, 2018.'
  ista: 'Maier RM, Visscher PM, Robinson MR, Wray NR. 2018. Embracing polygenicity:
    A review of methods and tools for psychiatric genetics research. Psychological
    Medicine. 48(7), 1055–1067.'
  mla: 'Maier, R. M., et al. “Embracing Polygenicity: A Review of Methods and Tools
    for Psychiatric Genetics Research.” <i>Psychological Medicine</i>, vol. 48, no.
    7, Cambridge University Press, 2018, pp. 1055–67, doi:<a href="https://doi.org/10.1017/s0033291717002318">10.1017/s0033291717002318</a>.'
  short: R.M. Maier, P.M. Visscher, M.R. Robinson, N.R. Wray, Psychological Medicine
    48 (2018) 1055–1067.
date_created: 2020-04-30T10:44:35Z
date_published: 2018-05-01T00:00:00Z
date_updated: 2021-01-12T08:15:05Z
day: '01'
doi: 10.1017/s0033291717002318
extern: '1'
intvolume: '        48'
issue: '7'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1017/s0033291717002318
month: '05'
oa: 1
oa_version: Published Version
page: 1055-1067
publication: Psychological Medicine
publication_identifier:
  issn:
  - 0033-2917
  - 1469-8978
publication_status: published
publisher: Cambridge University Press
quality_controlled: '1'
status: public
title: 'Embracing polygenicity: A review of methods and tools for psychiatric genetics
  research'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 48
year: '2018'
...