---
_id: '8818'
abstract:
- lang: eng
text: The hippocampus has a major role in encoding and consolidating long-term memories,
and undergoes plastic changes during sleep1. These changes require precise homeostatic
control by subcortical neuromodulatory structures2. The underlying mechanisms
of this phenomenon, however, remain unknown. Here, using multi-structure recordings
in macaque monkeys, we show that the brainstem transiently modulates hippocampal
network events through phasic pontine waves known as pontogeniculooccipital waves
(PGO waves). Two physiologically distinct types of PGO wave appear to occur sequentially,
selectively influencing high-frequency ripples and low-frequency theta events,
respectively. The two types of PGO wave are associated with opposite hippocampal
spike-field coupling, prompting periods of high neural synchrony of neural populations
during periods of ripple and theta instances. The coupling between PGO waves and
ripples, classically associated with distinct sleep stages, supports the notion
that a global coordination mechanism of hippocampal sleep dynamics by cholinergic
pontine transients may promote systems and synaptic memory consolidation as well
as synaptic homeostasis.
acknowledgement: We thank O. Eschenko and M. Constantinou for providing feedback on
earlier versions of this work, and J. Werner and M. Schnabel for technical support
during the development of this study. This research was supported by the Max Planck
Society.
article_processing_charge: No
article_type: original
author:
- first_name: Juan F
full_name: Ramirez Villegas, Juan F
id: 44B06F76-F248-11E8-B48F-1D18A9856A87
last_name: Ramirez Villegas
- first_name: Michel
full_name: Besserve, Michel
last_name: Besserve
- first_name: Yusuke
full_name: Murayama, Yusuke
last_name: Murayama
- first_name: Henry C.
full_name: Evrard, Henry C.
last_name: Evrard
- first_name: Axel
full_name: Oeltermann, Axel
last_name: Oeltermann
- first_name: Nikos K.
full_name: Logothetis, Nikos K.
last_name: Logothetis
citation:
ama: Ramirez Villegas JF, Besserve M, Murayama Y, Evrard HC, Oeltermann A, Logothetis
NK. Coupling of hippocampal theta and ripples with pontogeniculooccipital waves.
Nature. 2021;589(7840):96-102. doi:10.1038/s41586-020-2914-4
apa: Ramirez Villegas, J. F., Besserve, M., Murayama, Y., Evrard, H. C., Oeltermann,
A., & Logothetis, N. K. (2021). Coupling of hippocampal theta and ripples
with pontogeniculooccipital waves. Nature. Springer Nature. https://doi.org/10.1038/s41586-020-2914-4
chicago: Ramirez Villegas, Juan F, Michel Besserve, Yusuke Murayama, Henry C. Evrard,
Axel Oeltermann, and Nikos K. Logothetis. “Coupling of Hippocampal Theta and Ripples
with Pontogeniculooccipital Waves.” Nature. Springer Nature, 2021. https://doi.org/10.1038/s41586-020-2914-4.
ieee: J. F. Ramirez Villegas, M. Besserve, Y. Murayama, H. C. Evrard, A. Oeltermann,
and N. K. Logothetis, “Coupling of hippocampal theta and ripples with pontogeniculooccipital
waves,” Nature, vol. 589, no. 7840. Springer Nature, pp. 96–102, 2021.
ista: Ramirez Villegas JF, Besserve M, Murayama Y, Evrard HC, Oeltermann A, Logothetis
NK. 2021. Coupling of hippocampal theta and ripples with pontogeniculooccipital
waves. Nature. 589(7840), 96–102.
mla: Ramirez Villegas, Juan F., et al. “Coupling of Hippocampal Theta and Ripples
with Pontogeniculooccipital Waves.” Nature, vol. 589, no. 7840, Springer
Nature, 2021, pp. 96–102, doi:10.1038/s41586-020-2914-4.
short: J.F. Ramirez Villegas, M. Besserve, Y. Murayama, H.C. Evrard, A. Oeltermann,
N.K. Logothetis, Nature 589 (2021) 96–102.
date_created: 2020-11-29T23:01:19Z
date_published: 2021-01-07T00:00:00Z
date_updated: 2023-08-04T11:13:08Z
day: '07'
department:
- _id: JoCs
doi: 10.1038/s41586-020-2914-4
external_id:
isi:
- '000591047800005'
pmid:
- '33208951'
intvolume: ' 589'
isi: 1
issue: '7840'
language:
- iso: eng
month: '01'
oa_version: None
page: 96-102
pmid: 1
publication: Nature
publication_identifier:
eissn:
- '14764687'
issn:
- '00280836'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- relation: erratum
url: https://doi.org/10.1038/s41586-020-03068-9
scopus_import: '1'
status: public
title: Coupling of hippocampal theta and ripples with pontogeniculooccipital waves
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 589
year: '2021'
...
---
_id: '10223'
abstract:
- lang: eng
text: Growth regulation tailors development in plants to their environment. A prominent
example of this is the response to gravity, in which shoots bend up and roots
bend down1. This paradox is based on opposite effects of the phytohormone auxin,
which promotes cell expansion in shoots while inhibiting it in roots via a yet
unknown cellular mechanism2. Here, by combining microfluidics, live imaging, genetic
engineering and phosphoproteomics in Arabidopsis thaliana, we advance understanding
of how auxin inhibits root growth. We show that auxin activates two distinct,
antagonistically acting signalling pathways that converge on rapid regulation
of apoplastic pH, a causative determinant of growth. Cell surface-based TRANSMEMBRANE
KINASE1 (TMK1) interacts with and mediates phosphorylation and activation of plasma
membrane H+-ATPases for apoplast acidification, while intracellular canonical
auxin signalling promotes net cellular H+ influx, causing apoplast alkalinization.
Simultaneous activation of these two counteracting mechanisms poises roots for
rapid, fine-tuned growth modulation in navigating complex soil environments.
acknowledged_ssus:
- _id: LifeSc
- _id: M-Shop
- _id: Bio
acknowledgement: We thank N. Gnyliukh and L. Hörmayer for technical assistance and
N. Paris for sharing PM-Cyto seeds. We gratefully acknowledge the Life Science,
Machine Shop and Bioimaging Facilities of IST Austria. This project has received
funding from the European Research Council Advanced Grant (ETAP-742985) and the
Austrian Science Fund (FWF) under I 3630-B25 to J.F., the National Institutes of
Health (GM067203) to W.M.G., the Netherlands Organization for Scientific Research
(NWO; VIDI-864.13.001), Research Foundation-Flanders (FWO; Odysseus II G0D0515N)
and a European Research Council Starting Grant (TORPEDO-714055) to W.S. and B.D.R.,
the VICI grant (865.14.001) from the Netherlands Organization for Scientific Research
to M.R. and D.W., the Australian Research Council and China National Distinguished
Expert Project (WQ20174400441) to S.S., the MEXT/JSPS KAKENHI to K.T. (20K06685)
and T.K. (20H05687 and 20H05910), the European Union’s Horizon 2020 research and
innovation programme under Marie Skłodowska-Curie grant agreement no. 665385 and
the DOC Fellowship of the Austrian Academy of Sciences to L.L., and the China Scholarship
Council to J.C.
article_processing_charge: No
article_type: original
author:
- first_name: Lanxin
full_name: Li, Lanxin
id: 367EF8FA-F248-11E8-B48F-1D18A9856A87
last_name: Li
orcid: 0000-0002-5607-272X
- first_name: Inge
full_name: Verstraeten, Inge
id: 362BF7FE-F248-11E8-B48F-1D18A9856A87
last_name: Verstraeten
orcid: 0000-0001-7241-2328
- first_name: Mark
full_name: Roosjen, Mark
last_name: Roosjen
- first_name: Koji
full_name: Takahashi, Koji
last_name: Takahashi
- first_name: Lesia
full_name: Rodriguez Solovey, Lesia
id: 3922B506-F248-11E8-B48F-1D18A9856A87
last_name: Rodriguez Solovey
orcid: 0000-0002-7244-7237
- first_name: Jack
full_name: Merrin, Jack
id: 4515C308-F248-11E8-B48F-1D18A9856A87
last_name: Merrin
orcid: 0000-0001-5145-4609
- first_name: Jian
full_name: Chen, Jian
last_name: Chen
- first_name: Lana
full_name: Shabala, Lana
last_name: Shabala
- first_name: Wouter
full_name: Smet, Wouter
last_name: Smet
- first_name: Hong
full_name: Ren, Hong
last_name: Ren
- first_name: Steffen
full_name: Vanneste, Steffen
last_name: Vanneste
- first_name: Sergey
full_name: Shabala, Sergey
last_name: Shabala
- first_name: Bert
full_name: De Rybel, Bert
last_name: De Rybel
- first_name: Dolf
full_name: Weijers, Dolf
last_name: Weijers
- first_name: Toshinori
full_name: Kinoshita, Toshinori
last_name: Kinoshita
- first_name: William M.
full_name: Gray, William M.
last_name: Gray
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Li L, Verstraeten I, Roosjen M, et al. Cell surface and intracellular auxin
signalling for H+ fluxes in root growth. Nature. 2021;599(7884):273-277.
doi:10.1038/s41586-021-04037-6
apa: Li, L., Verstraeten, I., Roosjen, M., Takahashi, K., Rodriguez Solovey, L.,
Merrin, J., … Friml, J. (2021). Cell surface and intracellular auxin signalling
for H+ fluxes in root growth. Nature. Springer Nature. https://doi.org/10.1038/s41586-021-04037-6
chicago: Li, Lanxin, Inge Verstraeten, Mark Roosjen, Koji Takahashi, Lesia Rodriguez
Solovey, Jack Merrin, Jian Chen, et al. “Cell Surface and Intracellular Auxin
Signalling for H+ Fluxes in Root Growth.” Nature. Springer Nature,
2021. https://doi.org/10.1038/s41586-021-04037-6.
ieee: L. Li et al., “Cell surface and intracellular auxin signalling for
H+ fluxes in root growth,” Nature, vol. 599, no. 7884. Springer
Nature, pp. 273–277, 2021.
ista: Li L, Verstraeten I, Roosjen M, Takahashi K, Rodriguez Solovey L, Merrin J,
Chen J, Shabala L, Smet W, Ren H, Vanneste S, Shabala S, De Rybel B, Weijers D,
Kinoshita T, Gray WM, Friml J. 2021. Cell surface and intracellular auxin signalling
for H+ fluxes in root growth. Nature. 599(7884), 273–277.
mla: Li, Lanxin, et al. “Cell Surface and Intracellular Auxin Signalling for H+
Fluxes in Root Growth.” Nature, vol. 599, no. 7884, Springer Nature, 2021,
pp. 273–77, doi:10.1038/s41586-021-04037-6.
short: L. Li, I. Verstraeten, M. Roosjen, K. Takahashi, L. Rodriguez Solovey, J.
Merrin, J. Chen, L. Shabala, W. Smet, H. Ren, S. Vanneste, S. Shabala, B. De Rybel,
D. Weijers, T. Kinoshita, W.M. Gray, J. Friml, Nature 599 (2021) 273–277.
date_created: 2021-11-07T23:01:25Z
date_published: 2021-11-11T00:00:00Z
date_updated: 2024-10-29T10:22:45Z
day: '11'
department:
- _id: JiFr
- _id: NanoFab
doi: 10.1038/s41586-021-04037-6
ec_funded: 1
external_id:
isi:
- '000713338100006'
pmid:
- '34707283'
intvolume: ' 599'
isi: 1
issue: '7884'
keyword:
- Multidisciplinary
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.doi.org/10.21203/rs.3.rs-266395/v3
month: '11'
oa: 1
oa_version: Preprint
page: 273-277
pmid: 1
project:
- _id: 261099A6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '742985'
name: Tracing Evolution of Auxin Transport and Polarity in Plants
- _id: 26538374-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I03630
name: Molecular mechanisms of endocytic cargo recognition in plants
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
- _id: 26B4D67E-B435-11E9-9278-68D0E5697425
grant_number: '25351'
name: 'A Case Study of Plant Growth Regulation: Molecular Mechanism of Auxin-mediated
Rapid Growth Inhibition in Arabidopsis Root'
publication: Nature
publication_identifier:
eissn:
- '14764687'
issn:
- '00280836'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on IST Webpage
relation: press_release
url: https://ist.ac.at/en/news/stop-and-grow/
record:
- id: '10095'
relation: earlier_version
status: public
scopus_import: '1'
status: public
title: Cell surface and intracellular auxin signalling for H+ fluxes in
root growth
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 599
year: '2021'
...
---
_id: '7885'
abstract:
- lang: eng
text: Eukaryotic cells migrate by coupling the intracellular force of the actin
cytoskeleton to the environment. While force coupling is usually mediated by transmembrane
adhesion receptors, especially those of the integrin family, amoeboid cells such
as leukocytes can migrate extremely fast despite very low adhesive forces1. Here
we show that leukocytes cannot only migrate under low adhesion but can also transmit
forces in the complete absence of transmembrane force coupling. When confined
within three-dimensional environments, they use the topographical features of
the substrate to propel themselves. Here the retrograde flow of the actin cytoskeleton
follows the texture of the substrate, creating retrograde shear forces that are
sufficient to drive the cell body forwards. Notably, adhesion-dependent and adhesion-independent
migration are not mutually exclusive, but rather are variants of the same principle
of coupling retrograde actin flow to the environment and thus can potentially
operate interchangeably and simultaneously. As adhesion-free migration is independent
of the chemical composition of the environment, it renders cells completely autonomous
in their locomotive behaviour.
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
- _id: M-Shop
acknowledgement: We thank A. Leithner and J. Renkawitz for discussion and critical
reading of the manuscript; J. Schwarz and M. Mehling for establishing the microfluidic
setups; the Bioimaging Facility of IST Austria for excellent support, as well as
the Life Science Facility and the Miba Machine Shop of IST Austria; and F. N. Arslan,
L. E. Burnett and L. Li for their work during their rotation in the IST PhD programme.
This work was supported by the European Research Council (ERC StG 281556 and CoG
724373) to M.S. and grants from the Austrian Science Fund (FWF P29911) and the WWTF
to M.S. M.H. was supported by the European Regional Development Fund Project (CZ.02.1.01/0.0/0.0/15_003/0000476).
F.G. received funding from the European Union’s Horizon 2020 research and innovation
programme under the Marie Skłodowska-Curie grant agreement no. 747687.
article_processing_charge: No
article_type: original
author:
- first_name: Anne
full_name: Reversat, Anne
id: 35B76592-F248-11E8-B48F-1D18A9856A87
last_name: Reversat
orcid: 0000-0003-0666-8928
- first_name: Florian R
full_name: Gärtner, Florian R
id: 397A88EE-F248-11E8-B48F-1D18A9856A87
last_name: Gärtner
orcid: 0000-0001-6120-3723
- first_name: Jack
full_name: Merrin, Jack
id: 4515C308-F248-11E8-B48F-1D18A9856A87
last_name: Merrin
orcid: 0000-0001-5145-4609
- first_name: Julian A
full_name: Stopp, Julian A
id: 489E3F00-F248-11E8-B48F-1D18A9856A87
last_name: Stopp
- first_name: Saren
full_name: Tasciyan, Saren
id: 4323B49C-F248-11E8-B48F-1D18A9856A87
last_name: Tasciyan
orcid: 0000-0003-1671-393X
- first_name: Juan L
full_name: Aguilera Servin, Juan L
id: 2A67C376-F248-11E8-B48F-1D18A9856A87
last_name: Aguilera Servin
orcid: 0000-0002-2862-8372
- first_name: Ingrid
full_name: De Vries, Ingrid
id: 4C7D837E-F248-11E8-B48F-1D18A9856A87
last_name: De Vries
- first_name: Robert
full_name: Hauschild, Robert
id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
last_name: Hauschild
orcid: 0000-0001-9843-3522
- first_name: Miroslav
full_name: Hons, Miroslav
id: 4167FE56-F248-11E8-B48F-1D18A9856A87
last_name: Hons
orcid: 0000-0002-6625-3348
- first_name: Matthieu
full_name: Piel, Matthieu
last_name: Piel
- first_name: Andrew
full_name: Callan-Jones, Andrew
last_name: Callan-Jones
- first_name: Raphael
full_name: Voituriez, Raphael
last_name: Voituriez
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
citation:
ama: Reversat A, Gärtner FR, Merrin J, et al. Cellular locomotion using environmental
topography. Nature. 2020;582:582–585. doi:10.1038/s41586-020-2283-z
apa: Reversat, A., Gärtner, F. R., Merrin, J., Stopp, J. A., Tasciyan, S., Aguilera
Servin, J. L., … Sixt, M. K. (2020). Cellular locomotion using environmental topography.
Nature. Springer Nature. https://doi.org/10.1038/s41586-020-2283-z
chicago: Reversat, Anne, Florian R Gärtner, Jack Merrin, Julian A Stopp, Saren Tasciyan,
Juan L Aguilera Servin, Ingrid de Vries, et al. “Cellular Locomotion Using Environmental
Topography.” Nature. Springer Nature, 2020. https://doi.org/10.1038/s41586-020-2283-z.
ieee: A. Reversat et al., “Cellular locomotion using environmental topography,”
Nature, vol. 582. Springer Nature, pp. 582–585, 2020.
ista: Reversat A, Gärtner FR, Merrin J, Stopp JA, Tasciyan S, Aguilera Servin JL,
de Vries I, Hauschild R, Hons M, Piel M, Callan-Jones A, Voituriez R, Sixt MK.
2020. Cellular locomotion using environmental topography. Nature. 582, 582–585.
mla: Reversat, Anne, et al. “Cellular Locomotion Using Environmental Topography.”
Nature, vol. 582, Springer Nature, 2020, pp. 582–585, doi:10.1038/s41586-020-2283-z.
short: A. Reversat, F.R. Gärtner, J. Merrin, J.A. Stopp, S. Tasciyan, J.L. Aguilera
Servin, I. de Vries, R. Hauschild, M. Hons, M. Piel, A. Callan-Jones, R. Voituriez,
M.K. Sixt, Nature 582 (2020) 582–585.
date_created: 2020-05-24T22:01:01Z
date_published: 2020-06-25T00:00:00Z
date_updated: 2024-03-25T23:30:12Z
day: '25'
department:
- _id: NanoFab
- _id: Bio
- _id: MiSi
doi: 10.1038/s41586-020-2283-z
ec_funded: 1
external_id:
isi:
- '000532688300008'
intvolume: ' 582'
isi: 1
language:
- iso: eng
month: '06'
oa_version: None
page: 582–585
project:
- _id: 25A603A2-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '281556'
name: Cytoskeletal force generation and force transduction of migrating leukocytes
- _id: 25FE9508-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '724373'
name: Cellular navigation along spatial gradients
- _id: 26018E70-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P29911
name: Mechanical adaptation of lamellipodial actin
- _id: 260AA4E2-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '747687'
name: Mechanical Adaptation of Lamellipodial Actin Networks in Migrating Cells
publication: Nature
publication_identifier:
eissn:
- '14764687'
issn:
- '00280836'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/off-road-mode-enables-mobile-cells-to-move-freely/
record:
- id: '14697'
relation: dissertation_contains
status: public
- id: '12401'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Cellular locomotion using environmental topography
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 582
year: '2020'
...
---
_id: '6836'
abstract:
- lang: eng
text: Direct reciprocity is a powerful mechanism for the evolution of cooperation
on the basis of repeated interactions1,2,3,4. It requires that interacting individuals
are sufficiently equal, such that everyone faces similar consequences when they
cooperate or defect. Yet inequality is ubiquitous among humans5,6 and is generally
considered to undermine cooperation and welfare7,8,9,10. Most previous models
of reciprocity do not include inequality11,12,13,14,15. These models assume that
individuals are the same in all relevant aspects. Here we introduce a general
framework to study direct reciprocity among unequal individuals. Our model allows
for multiple sources of inequality. Subjects can differ in their endowments, their
productivities and in how much they benefit from public goods. We find that extreme
inequality prevents cooperation. But if subjects differ in productivity, some
endowment inequality can be necessary for cooperation to prevail. Our mathematical
predictions are supported by a behavioural experiment in which we vary the endowments
and productivities of the subjects. We observe that overall welfare is maximized
when the two sources of heterogeneity are aligned, such that more productive individuals
receive higher endowments. By contrast, when endowments and productivities are
misaligned, cooperation quickly breaks down. Our findings have implications for
policy-makers concerned with equity, efficiency and the provisioning of public
goods.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Oliver P.
full_name: Hauser, Oliver P.
last_name: Hauser
- first_name: Christian
full_name: Hilbe, Christian
id: 2FDF8F3C-F248-11E8-B48F-1D18A9856A87
last_name: Hilbe
orcid: 0000-0001-5116-955X
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Martin A.
full_name: Nowak, Martin A.
last_name: Nowak
citation:
ama: Hauser OP, Hilbe C, Chatterjee K, Nowak MA. Social dilemmas among unequals.
Nature. 2019;572(7770):524-527. doi:10.1038/s41586-019-1488-5
apa: Hauser, O. P., Hilbe, C., Chatterjee, K., & Nowak, M. A. (2019). Social
dilemmas among unequals. Nature. Springer Nature. https://doi.org/10.1038/s41586-019-1488-5
chicago: Hauser, Oliver P., Christian Hilbe, Krishnendu Chatterjee, and Martin A.
Nowak. “Social Dilemmas among Unequals.” Nature. Springer Nature, 2019.
https://doi.org/10.1038/s41586-019-1488-5.
ieee: O. P. Hauser, C. Hilbe, K. Chatterjee, and M. A. Nowak, “Social dilemmas among
unequals,” Nature, vol. 572, no. 7770. Springer Nature, pp. 524–527, 2019.
ista: Hauser OP, Hilbe C, Chatterjee K, Nowak MA. 2019. Social dilemmas among unequals.
Nature. 572(7770), 524–527.
mla: Hauser, Oliver P., et al. “Social Dilemmas among Unequals.” Nature,
vol. 572, no. 7770, Springer Nature, 2019, pp. 524–27, doi:10.1038/s41586-019-1488-5.
short: O.P. Hauser, C. Hilbe, K. Chatterjee, M.A. Nowak, Nature 572 (2019) 524–527.
date_created: 2019-09-01T22:00:56Z
date_published: 2019-08-22T00:00:00Z
date_updated: 2023-08-29T07:42:54Z
day: '22'
ddc:
- '000'
department:
- _id: KrCh
doi: 10.1038/s41586-019-1488-5
ec_funded: 1
external_id:
isi:
- '000482219600045'
file:
- access_level: open_access
checksum: a6e0e3168bf62de624e7772cdfaeb26f
content_type: application/pdf
creator: dernst
date_created: 2020-05-14T10:00:32Z
date_updated: 2020-07-14T12:47:42Z
file_id: '7828'
file_name: 2019_Nature_Hauser.pdf
file_size: 18577756
relation: main_file
file_date_updated: 2020-07-14T12:47:42Z
has_accepted_license: '1'
intvolume: ' 572'
isi: 1
issue: '7770'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Submitted Version
page: 524-527
project:
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: Nature
publication_identifier:
eissn:
- '14764687'
issn:
- '00280836'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/too-much-inequality-impedes-support-for-public-goods-according-to-research-published-in-nature/
scopus_import: '1'
status: public
title: Social dilemmas among unequals
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 572
year: '2019'
...
---
_id: '6348'
abstract:
- lang: eng
text: 'High-speed optical telecommunication is enabled by wavelength-division multiplexing,
whereby hundreds of individually stabilized lasers encode information within a
single-mode optical fibre. Higher bandwidths require higher total optical power,
but the power sent into the fibre is limited by optical nonlinearities within
the fibre, and energy consumption by the light sources starts to become a substantial
cost factor1. Optical frequency combs have been suggested to remedy this problem
by generating numerous discrete, equidistant laser lines within a monolithic device;
however, at present their stability and coherence allow them to operate only within
small parameter ranges2,3,4. Here we show that a broadband frequency comb realized
through the electro-optic effect within a high-quality whispering-gallery-mode
resonator can operate at low microwave and optical powers. Unlike the usual third-order
Kerr nonlinear optical frequency combs, our combs rely on the second-order nonlinear
effect, which is much more efficient. Our result uses a fixed microwave signal
that is mixed with an optical-pump signal to generate a coherent frequency comb
with a precisely determined carrier separation. The resonant enhancement enables
us to work with microwave powers that are three orders of magnitude lower than
those in commercially available devices. We emphasize the practical relevance
of our results to high rates of data communication. To circumvent the limitations
imposed by nonlinear effects in optical communication fibres, one has to solve
two problems: to provide a compact and fully integrated, yet high-quality and
coherent, frequency comb generator; and to calculate nonlinear signal propagation
in real time5. We report a solution to the first problem.'
article_processing_charge: No
arxiv: 1
author:
- first_name: Alfredo R
full_name: Rueda Sanchez, Alfredo R
id: 3B82B0F8-F248-11E8-B48F-1D18A9856A87
last_name: Rueda Sanchez
orcid: 0000-0001-6249-5860
- first_name: Florian
full_name: Sedlmeir, Florian
last_name: Sedlmeir
- first_name: Madhuri
full_name: Kumari, Madhuri
last_name: Kumari
- first_name: Gerd
full_name: Leuchs, Gerd
last_name: Leuchs
- first_name: Harald G.L.
full_name: Schwefel, Harald G.L.
last_name: Schwefel
citation:
ama: Rueda Sanchez AR, Sedlmeir F, Kumari M, Leuchs G, Schwefel HGL. Resonant electro-optic
frequency comb. Nature. 2019;568(7752):378-381. doi:10.1038/s41586-019-1110-x
apa: Rueda Sanchez, A. R., Sedlmeir, F., Kumari, M., Leuchs, G., & Schwefel,
H. G. L. (2019). Resonant electro-optic frequency comb. Nature. Springer
Nature. https://doi.org/10.1038/s41586-019-1110-x
chicago: Rueda Sanchez, Alfredo R, Florian Sedlmeir, Madhuri Kumari, Gerd Leuchs,
and Harald G.L. Schwefel. “Resonant Electro-Optic Frequency Comb.” Nature.
Springer Nature, 2019. https://doi.org/10.1038/s41586-019-1110-x.
ieee: A. R. Rueda Sanchez, F. Sedlmeir, M. Kumari, G. Leuchs, and H. G. L. Schwefel,
“Resonant electro-optic frequency comb,” Nature, vol. 568, no. 7752. Springer
Nature, pp. 378–381, 2019.
ista: Rueda Sanchez AR, Sedlmeir F, Kumari M, Leuchs G, Schwefel HGL. 2019. Resonant
electro-optic frequency comb. Nature. 568(7752), 378–381.
mla: Rueda Sanchez, Alfredo R., et al. “Resonant Electro-Optic Frequency Comb.”
Nature, vol. 568, no. 7752, Springer Nature, 2019, pp. 378–81, doi:10.1038/s41586-019-1110-x.
short: A.R. Rueda Sanchez, F. Sedlmeir, M. Kumari, G. Leuchs, H.G.L. Schwefel, Nature
568 (2019) 378–381.
date_created: 2019-04-28T21:59:13Z
date_published: 2019-04-18T00:00:00Z
date_updated: 2023-08-25T10:15:25Z
day: '18'
department:
- _id: JoFi
doi: 10.1038/s41586-019-1110-x
external_id:
arxiv:
- '1808.10608'
isi:
- '000464950700053'
intvolume: ' 568'
isi: 1
issue: '7752'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1808.10608
month: '04'
oa: 1
oa_version: Preprint
page: 378-381
publication: Nature
publication_identifier:
eissn:
- '14764687'
issn:
- '00280836'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- relation: erratum
url: https://doi.org/10.1038/s41586-019-1220-5
scopus_import: '1'
status: public
title: Resonant electro-optic frequency comb
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 568
year: '2019'
...
---
_id: '6513'
abstract:
- lang: eng
text: Adult intestinal stem cells are located at the bottom of crypts of Lieberkühn,
where they express markers such as LGR5 1,2 and fuel the constant replenishment
of the intestinal epithelium1. Although fetal LGR5-expressing cells can give rise
to adult intestinal stem cells3,4, it remains unclear whether this population
in the patterned epithelium represents unique intestinal stem-cell precursors.
Here we show, using unbiased quantitative lineage-tracing approaches, biophysical
modelling and intestinal transplantation, that all cells of the mouse intestinal
epithelium—irrespective of their location and pattern of LGR5 expression in the
fetal gut tube—contribute actively to the adult intestinal stem cell pool. Using
3D imaging, we find that during fetal development the villus undergoes gross remodelling
and fission. This brings epithelial cells from the non-proliferative villus into
the proliferative intervillus region, which enables them to contribute to the
adult stem-cell niche. Our results demonstrate that large-scale remodelling of
the intestinal wall and cell-fate specification are closely linked. Moreover,
these findings provide a direct link between the observed plasticity and cellular
reprogramming of differentiating cells in adult tissues following damage5,6,7,8,9,
revealing that stem-cell identity is an induced rather than a hardwired property.
article_processing_charge: No
article_type: original
author:
- first_name: Jordi
full_name: Guiu, Jordi
last_name: Guiu
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Shiro
full_name: Yui, Shiro
last_name: Yui
- first_name: Samuel
full_name: Demharter, Samuel
last_name: Demharter
- first_name: Svetlana
full_name: Ulyanchenko, Svetlana
last_name: Ulyanchenko
- first_name: Martti
full_name: Maimets, Martti
last_name: Maimets
- first_name: Anne
full_name: Jørgensen, Anne
last_name: Jørgensen
- first_name: Signe
full_name: Perlman, Signe
last_name: Perlman
- first_name: Lene
full_name: Lundvall, Lene
last_name: Lundvall
- first_name: Linn Salto
full_name: Mamsen, Linn Salto
last_name: Mamsen
- first_name: Agnete
full_name: Larsen, Agnete
last_name: Larsen
- first_name: Rasmus H.
full_name: Olesen, Rasmus H.
last_name: Olesen
- first_name: Claus Yding
full_name: Andersen, Claus Yding
last_name: Andersen
- first_name: Lea Langhoff
full_name: Thuesen, Lea Langhoff
last_name: Thuesen
- first_name: Kristine Juul
full_name: Hare, Kristine Juul
last_name: Hare
- first_name: Tune H.
full_name: Pers, Tune H.
last_name: Pers
- first_name: Konstantin
full_name: Khodosevich, Konstantin
last_name: Khodosevich
- first_name: Benjamin D.
full_name: Simons, Benjamin D.
last_name: Simons
- first_name: Kim B.
full_name: Jensen, Kim B.
last_name: Jensen
citation:
ama: Guiu J, Hannezo EB, Yui S, et al. Tracing the origin of adult intestinal stem
cells. Nature. 2019;570:107-111. doi:10.1038/s41586-019-1212-5
apa: Guiu, J., Hannezo, E. B., Yui, S., Demharter, S., Ulyanchenko, S., Maimets,
M., … Jensen, K. B. (2019). Tracing the origin of adult intestinal stem cells.
Nature. Springer Nature. https://doi.org/10.1038/s41586-019-1212-5
chicago: Guiu, Jordi, Edouard B Hannezo, Shiro Yui, Samuel Demharter, Svetlana Ulyanchenko,
Martti Maimets, Anne Jørgensen, et al. “Tracing the Origin of Adult Intestinal
Stem Cells.” Nature. Springer Nature, 2019. https://doi.org/10.1038/s41586-019-1212-5.
ieee: J. Guiu et al., “Tracing the origin of adult intestinal stem cells,”
Nature, vol. 570. Springer Nature, pp. 107–111, 2019.
ista: Guiu J, Hannezo EB, Yui S, Demharter S, Ulyanchenko S, Maimets M, Jørgensen
A, Perlman S, Lundvall L, Mamsen LS, Larsen A, Olesen RH, Andersen CY, Thuesen
LL, Hare KJ, Pers TH, Khodosevich K, Simons BD, Jensen KB. 2019. Tracing the origin
of adult intestinal stem cells. Nature. 570, 107–111.
mla: Guiu, Jordi, et al. “Tracing the Origin of Adult Intestinal Stem Cells.” Nature,
vol. 570, Springer Nature, 2019, pp. 107–11, doi:10.1038/s41586-019-1212-5.
short: J. Guiu, E.B. Hannezo, S. Yui, S. Demharter, S. Ulyanchenko, M. Maimets,
A. Jørgensen, S. Perlman, L. Lundvall, L.S. Mamsen, A. Larsen, R.H. Olesen, C.Y.
Andersen, L.L. Thuesen, K.J. Hare, T.H. Pers, K. Khodosevich, B.D. Simons, K.B.
Jensen, Nature 570 (2019) 107–111.
date_created: 2019-06-02T21:59:14Z
date_published: 2019-06-06T00:00:00Z
date_updated: 2023-08-28T09:30:23Z
day: '06'
department:
- _id: EdHa
doi: 10.1038/s41586-019-1212-5
external_id:
isi:
- '000470149000048'
pmid:
- '31092921'
intvolume: ' 570'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986928
month: '06'
oa: 1
oa_version: Submitted Version
page: 107-111
pmid: 1
publication: Nature
publication_identifier:
eissn:
- '14764687'
issn:
- '00280836'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Tracing the origin of adult intestinal stem cells
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 570
year: '2019'
...
---
_id: '651'
abstract:
- lang: eng
text: "Superhydrophobic surfaces reduce the frictional drag between water and solid
materials, but this effect is often temporary. The realization of sustained drag
reduction has applications for water vehicles and pipeline flows.\r\n\r\n"
author:
- first_name: Björn
full_name: Hof, Björn
id: 3A374330-F248-11E8-B48F-1D18A9856A87
last_name: Hof
orcid: 0000-0003-2057-2754
citation:
ama: 'Hof B. Fluid dynamics: Water flows out of touch. Nature. 2017;541(7636):161-162.
doi:10.1038/541161a'
apa: 'Hof, B. (2017). Fluid dynamics: Water flows out of touch. Nature. Nature
Publishing Group. https://doi.org/10.1038/541161a'
chicago: 'Hof, Björn. “Fluid Dynamics: Water Flows out of Touch.” Nature.
Nature Publishing Group, 2017. https://doi.org/10.1038/541161a.'
ieee: 'B. Hof, “Fluid dynamics: Water flows out of touch,” Nature, vol. 541,
no. 7636. Nature Publishing Group, pp. 161–162, 2017.'
ista: 'Hof B. 2017. Fluid dynamics: Water flows out of touch. Nature. 541(7636),
161–162.'
mla: 'Hof, Björn. “Fluid Dynamics: Water Flows out of Touch.” Nature, vol.
541, no. 7636, Nature Publishing Group, 2017, pp. 161–62, doi:10.1038/541161a.'
short: B. Hof, Nature 541 (2017) 161–162.
date_created: 2018-12-11T11:47:43Z
date_published: 2017-01-11T00:00:00Z
date_updated: 2021-01-12T08:07:49Z
day: '11'
department:
- _id: BjHo
doi: 10.1038/541161a
intvolume: ' 541'
issue: '7636'
language:
- iso: eng
month: '01'
oa_version: None
page: 161 - 162
publication: Nature
publication_identifier:
issn:
- '00280836'
publication_status: published
publisher: Nature Publishing Group
publist_id: '7116'
quality_controlled: '1'
scopus_import: 1
status: public
title: 'Fluid dynamics: Water flows out of touch'
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 541
year: '2017'
...
---
_id: '934'
abstract:
- lang: eng
text: During puberty, the mouse mammary gland develops into a highly branched epithelial
network. Owing to the absence of exclusive stem cell markers, the location, multiplicity,
dynamics and fate of mammary stem cells (MaSCs), which drive branching morphogenesis,
are unknown. Here we show that morphogenesis is driven by proliferative terminal
end buds that terminate or bifurcate with near equal probability, in a stochastic
and time-invariant manner, leading to a heterogeneous epithelial network. We show
that the majority of terminal end bud cells function as highly proliferative,
lineage-committed MaSCs that are heterogeneous in their expression profile and
short-term contribution to ductal extension. Yet, through cell rearrangements
during terminal end bud bifurcation, each MaSC is able to contribute actively
to long-term growth. Our study shows that the behaviour of MaSCs is not directly
linked to a single expression profile. Instead, morphogenesis relies upon lineage-restricted
heterogeneous MaSC populations that function as single equipotent pools in the
long term.
author:
- first_name: Colinda
full_name: Scheele, Colinda
last_name: Scheele
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Mauro
full_name: Muraro, Mauro
last_name: Muraro
- first_name: Anoek
full_name: Zomer, Anoek
last_name: Zomer
- first_name: Nathalia
full_name: Langedijk, Nathalia
last_name: Langedijk
- first_name: Alexander
full_name: Van Oudenaarden, Alexander
last_name: Van Oudenaarden
- first_name: Benjamin
full_name: Simons, Benjamin
last_name: Simons
- first_name: Jacco
full_name: Van Rheenen, Jacco
last_name: Van Rheenen
citation:
ama: Scheele C, Hannezo EB, Muraro M, et al. Identity and dynamics of mammary stem
cells during branching morphogenesis. Nature. 2017;542(7641):313-317. doi:10.1038/nature21046
apa: Scheele, C., Hannezo, E. B., Muraro, M., Zomer, A., Langedijk, N., Van Oudenaarden,
A., … Van Rheenen, J. (2017). Identity and dynamics of mammary stem cells during
branching morphogenesis. Nature. Nature Publishing Group. https://doi.org/10.1038/nature21046
chicago: Scheele, Colinda, Edouard B Hannezo, Mauro Muraro, Anoek Zomer, Nathalia
Langedijk, Alexander Van Oudenaarden, Benjamin Simons, and Jacco Van Rheenen.
“Identity and Dynamics of Mammary Stem Cells during Branching Morphogenesis.”
Nature. Nature Publishing Group, 2017. https://doi.org/10.1038/nature21046.
ieee: C. Scheele et al., “Identity and dynamics of mammary stem cells during
branching morphogenesis,” Nature, vol. 542, no. 7641. Nature Publishing
Group, pp. 313–317, 2017.
ista: Scheele C, Hannezo EB, Muraro M, Zomer A, Langedijk N, Van Oudenaarden A,
Simons B, Van Rheenen J. 2017. Identity and dynamics of mammary stem cells during
branching morphogenesis. Nature. 542(7641), 313–317.
mla: Scheele, Colinda, et al. “Identity and Dynamics of Mammary Stem Cells during
Branching Morphogenesis.” Nature, vol. 542, no. 7641, Nature Publishing
Group, 2017, pp. 313–17, doi:10.1038/nature21046.
short: C. Scheele, E.B. Hannezo, M. Muraro, A. Zomer, N. Langedijk, A. Van Oudenaarden,
B. Simons, J. Van Rheenen, Nature 542 (2017) 313–317.
date_created: 2018-12-11T11:49:17Z
date_published: 2017-02-16T00:00:00Z
date_updated: 2021-01-12T08:22:01Z
day: '16'
doi: 10.1038/nature21046
extern: '1'
intvolume: ' 542'
issue: '7641'
language:
- iso: eng
month: '02'
oa_version: None
page: 313 - 317
publication: Nature
publication_identifier:
issn:
- '00280836'
publication_status: published
publisher: Nature Publishing Group
publist_id: '6505'
quality_controlled: '1'
status: public
title: Identity and dynamics of mammary stem cells during branching morphogenesis
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 542
year: '2017'
...
---
_id: '937'
abstract:
- lang: eng
text: During epithelial cytokinesis, the remodelling of adhesive cell-cell contacts
between the dividing cell and its neighbours has profound implications for the
integrity, arrangement and morphogenesis of proliferative tissues. In both vertebrates
and invertebrates, this remodelling requires the activity of non-muscle myosin
II (MyoII) in the interphasic cells neighbouring the dividing cell. However, the
mechanisms that coordinate cytokinesis and MyoII activity in the neighbours are
unknown. Here we show that in the Drosophila notum epithelium, each cell division
is associated with a mechanosensing and transmission event that controls MyoII
dynamics in neighbouring cells. We find that the ring pulling forces promote local
junction elongation, which results in local E-cadherin dilution at the ingressing
adherens junction. In turn, the reduction in E-cadherin concentration and the
contractility of the neighbouring cells promote self-organized actomyosin flows,
ultimately leading to accumulation of MyoII at the base of the ingressing junction.
Although force transduction has been extensively studied in the context of adherens
junction reinforcement to stabilize adhesive cell-cell contacts, we propose an
alternative mechanosensing mechanism that coordinates actomyosin dynamics between
epithelial cells and sustains the remodelling of the adherens junction in response
to mechanical forces.
author:
- first_name: Diana
full_name: Pinheiro, Diana
last_name: Pinheiro
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Sophie
full_name: Herszterg, Sophie
last_name: Herszterg
- first_name: Floris
full_name: Bosveld, Floris
last_name: Bosveld
- first_name: Isabelle
full_name: Gaugué, Isabelle
last_name: Gaugué
- first_name: Maria
full_name: Balakireva, Maria
last_name: Balakireva
- first_name: Zhimin
full_name: Wang, Zhimin
last_name: Wang
- first_name: Inês
full_name: Cristo, Inês
last_name: Cristo
- first_name: Stéphane
full_name: Rigaud, Stéphane
last_name: Rigaud
- first_name: Olga
full_name: Markova, Olga
last_name: Markova
- first_name: Yohanns
full_name: Bellaïche, Yohanns
last_name: Bellaïche
citation:
ama: Pinheiro D, Hannezo EB, Herszterg S, et al. Transmission of cytokinesis forces
via E cadherin dilution and actomyosin flows. Nature. 2017;545(7652):103-107.
doi:10.1038/nature22041
apa: Pinheiro, D., Hannezo, E. B., Herszterg, S., Bosveld, F., Gaugué, I., Balakireva,
M., … Bellaïche, Y. (2017). Transmission of cytokinesis forces via E cadherin
dilution and actomyosin flows. Nature. Nature Publishing Group. https://doi.org/10.1038/nature22041
chicago: Pinheiro, Diana, Edouard B Hannezo, Sophie Herszterg, Floris Bosveld, Isabelle
Gaugué, Maria Balakireva, Zhimin Wang, et al. “Transmission of Cytokinesis Forces
via E Cadherin Dilution and Actomyosin Flows.” Nature. Nature Publishing
Group, 2017. https://doi.org/10.1038/nature22041.
ieee: D. Pinheiro et al., “Transmission of cytokinesis forces via E cadherin
dilution and actomyosin flows,” Nature, vol. 545, no. 7652. Nature Publishing
Group, pp. 103–107, 2017.
ista: Pinheiro D, Hannezo EB, Herszterg S, Bosveld F, Gaugué I, Balakireva M, Wang
Z, Cristo I, Rigaud S, Markova O, Bellaïche Y. 2017. Transmission of cytokinesis
forces via E cadherin dilution and actomyosin flows. Nature. 545(7652), 103–107.
mla: Pinheiro, Diana, et al. “Transmission of Cytokinesis Forces via E Cadherin
Dilution and Actomyosin Flows.” Nature, vol. 545, no. 7652, Nature Publishing
Group, 2017, pp. 103–07, doi:10.1038/nature22041.
short: D. Pinheiro, E.B. Hannezo, S. Herszterg, F. Bosveld, I. Gaugué, M. Balakireva,
Z. Wang, I. Cristo, S. Rigaud, O. Markova, Y. Bellaïche, Nature 545 (2017) 103–107.
date_created: 2018-12-11T11:49:18Z
date_published: 2017-05-04T00:00:00Z
date_updated: 2021-01-12T08:22:02Z
day: '04'
doi: 10.1038/nature22041
extern: '1'
intvolume: ' 545'
issue: '7652'
language:
- iso: eng
month: '05'
oa_version: None
page: 103 - 107
publication: Nature
publication_identifier:
issn:
- '00280836'
publication_status: published
publisher: Nature Publishing Group
publist_id: '6504'
quality_controlled: '1'
status: public
title: Transmission of cytokinesis forces via E cadherin dilution and actomyosin flows
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 545
year: '2017'
...
---
_id: '1025'
abstract:
- lang: eng
text: Many organ surfaces are covered by a protective epithelial-cell layer. It
emerges that such layers are maintained by cell stretching that triggers cell
division mediated by the force-sensitive ion-channel protein Piezo1. See Letter
p.118
article_processing_charge: No
author:
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: 'Heisenberg C-PJ. Cell biology: Stretched divisions. Nature. 2017;543(7643):43-44.
doi:10.1038/nature21502'
apa: 'Heisenberg, C.-P. J. (2017). Cell biology: Stretched divisions. Nature.
Nature Publishing Group. https://doi.org/10.1038/nature21502'
chicago: 'Heisenberg, Carl-Philipp J. “Cell Biology: Stretched Divisions.” Nature.
Nature Publishing Group, 2017. https://doi.org/10.1038/nature21502.'
ieee: 'C.-P. J. Heisenberg, “Cell biology: Stretched divisions,” Nature,
vol. 543, no. 7643. Nature Publishing Group, pp. 43–44, 2017.'
ista: 'Heisenberg C-PJ. 2017. Cell biology: Stretched divisions. Nature. 543(7643),
43–44.'
mla: 'Heisenberg, Carl-Philipp J. “Cell Biology: Stretched Divisions.” Nature,
vol. 543, no. 7643, Nature Publishing Group, 2017, pp. 43–44, doi:10.1038/nature21502.'
short: C.-P.J. Heisenberg, Nature 543 (2017) 43–44.
date_created: 2018-12-11T11:49:45Z
date_published: 2017-03-02T00:00:00Z
date_updated: 2023-09-22T09:26:59Z
day: '02'
department:
- _id: CaHe
doi: 10.1038/nature21502
external_id:
isi:
- '000395671500025'
intvolume: ' 543'
isi: 1
issue: '7643'
language:
- iso: eng
month: '03'
oa_version: None
page: 43 - 44
publication: Nature
publication_identifier:
issn:
- '00280836'
publication_status: published
publisher: Nature Publishing Group
publist_id: '6367'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Cell biology: Stretched divisions'
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 543
year: '2017'
...
---
_id: '2235'
abstract:
- lang: eng
text: Emerging infectious diseases (EIDs) pose a risk to human welfare, both directly
and indirectly, by affecting managed livestock and wildlife that provide valuable
resources and ecosystem services, such as the pollination of crops. Honeybees
(Apis mellifera), the prevailing managed insect crop pollinator, suffer from a
range of emerging and exotic high-impact pathogens, and population maintenance
requires active management by beekeepers to control them. Wild pollinators such
as bumblebees (Bombus spp.) are in global decline, one cause of which may be pathogen
spillover from managed pollinators like honeybees or commercial colonies of bumblebees.
Here we use a combination of infection experiments and landscape-scale field data
to show that honeybee EIDs are indeed widespread infectious agents within the
pollinator assemblage. The prevalence of deformed wing virus (DWV) and the exotic
parasite Nosema ceranae in honeybees and bumblebees is linked; as honeybees have
higher DWV prevalence, and sympatric bumblebees and honeybees are infected by
the same DWV strains, Apis is the likely source of at least one major EID in wild
pollinators. Lessons learned from vertebrates highlight the need for increased
pathogen control in managed bee species to maintain wild pollinators, as declines
in native pollinators may be caused by interspecies pathogen transmission originating
from managed pollinators.
author:
- first_name: Matthias
full_name: Fürst, Matthias
id: 393B1196-F248-11E8-B48F-1D18A9856A87
last_name: Fürst
orcid: 0000-0002-3712-925X
- first_name: Dino
full_name: Mcmahon, Dino
last_name: Mcmahon
- first_name: Juliet
full_name: Osborne, Juliet
last_name: Osborne
- first_name: Robert
full_name: Paxton, Robert
last_name: Paxton
- first_name: Mark
full_name: Brown, Mark
last_name: Brown
citation:
ama: Fürst M, Mcmahon D, Osborne J, Paxton R, Brown M. Disease associations between
honeybees and bumblebees as a threat to wild pollinators. Nature. 2014;506(7488):364-366.
doi:10.1038/nature12977
apa: Fürst, M., Mcmahon, D., Osborne, J., Paxton, R., & Brown, M. (2014). Disease
associations between honeybees and bumblebees as a threat to wild pollinators.
Nature. Nature Publishing Group. https://doi.org/10.1038/nature12977
chicago: Fürst, Matthias, Dino Mcmahon, Juliet Osborne, Robert Paxton, and Mark
Brown. “Disease Associations between Honeybees and Bumblebees as a Threat to Wild
Pollinators.” Nature. Nature Publishing Group, 2014. https://doi.org/10.1038/nature12977.
ieee: M. Fürst, D. Mcmahon, J. Osborne, R. Paxton, and M. Brown, “Disease associations
between honeybees and bumblebees as a threat to wild pollinators,” Nature,
vol. 506, no. 7488. Nature Publishing Group, pp. 364–366, 2014.
ista: Fürst M, Mcmahon D, Osborne J, Paxton R, Brown M. 2014. Disease associations
between honeybees and bumblebees as a threat to wild pollinators. Nature. 506(7488),
364–366.
mla: Fürst, Matthias, et al. “Disease Associations between Honeybees and Bumblebees
as a Threat to Wild Pollinators.” Nature, vol. 506, no. 7488, Nature Publishing
Group, 2014, pp. 364–66, doi:10.1038/nature12977.
short: M. Fürst, D. Mcmahon, J. Osborne, R. Paxton, M. Brown, Nature 506 (2014)
364–366.
date_created: 2018-12-11T11:56:29Z
date_published: 2014-02-20T00:00:00Z
date_updated: 2021-01-12T06:56:11Z
day: '20'
department:
- _id: SyCr
doi: 10.1038/nature12977
intvolume: ' 506'
issue: '7488'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985068/
month: '02'
oa: 1
oa_version: Submitted Version
page: 364 - 366
publication: Nature
publication_identifier:
issn:
- '00280836'
publication_status: published
publisher: Nature Publishing Group
publist_id: '4726'
quality_controlled: '1'
scopus_import: 1
status: public
title: Disease associations between honeybees and bumblebees as a threat to wild pollinators
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 506
year: '2014'
...