[{"date_created":"2018-12-11T12:08:02Z","date_published":"1998-10-01T00:00:00Z","month":"10","doi":"10.1038/27338","year":"1998","language":[{"iso":"eng"}],"publisher":"Nature Publishing Group","scopus_import":"1","title":"The geometry of adaptation","volume":395,"date_updated":"2022-08-24T13:50:49Z","publist_id":"1802","page":"751 - 752","article_processing_charge":"No","issue":"6704","publication":"Nature","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","quality_controlled":"1","oa_version":"None","_id":"4283","extern":"1","publication_identifier":{"issn":["0028-0836"]},"type":"review","publication_status":"published","citation":{"mla":"Barton, Nicholas H. “The Geometry of Adaptation.” <i>Nature</i>, vol. 395, no. 6704, Nature Publishing Group, 1998, pp. 751–52, doi:<a href=\"https://doi.org/10.1038/27338\">10.1038/27338</a>.","ama":"Barton NH. The geometry of adaptation. <i>Nature</i>. 1998;395(6704):751-752. doi:<a href=\"https://doi.org/10.1038/27338\">10.1038/27338</a>","ista":"Barton NH. 1998. The geometry of adaptation. Nature. 395(6704), 751–752.","short":"N.H. Barton, Nature 395 (1998) 751–752.","apa":"Barton, N. H. (1998). The geometry of adaptation. <i>Nature</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/27338\">https://doi.org/10.1038/27338</a>","ieee":"N. H. Barton, “The geometry of adaptation,” <i>Nature</i>, vol. 395, no. 6704. Nature Publishing Group, pp. 751–752, 1998.","chicago":"Barton, Nicholas H. “The Geometry of Adaptation.” <i>Nature</i>. Nature Publishing Group, 1998. <a href=\"https://doi.org/10.1038/27338\">https://doi.org/10.1038/27338</a>."},"day":"01","author":[{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","full_name":"Barton, Nicholas H","last_name":"Barton","orcid":"0000-0002-8548-5240","first_name":"Nicholas H"}],"status":"public","intvolume":"       395"},{"_id":"2570","pmid":1,"publication_identifier":{"issn":["0028-0836"]},"extern":"1","acknowledgement":"We thank E. Molnar for help in immunoblotting; A. D. Smith for comments on the manuscript; D. Latawiec fortechnical assistance; and P. Jays and F. Kennedy for photographic assistance. This work was partly supported by the Ministry of Education, Science and Culture of Japan. AK. is supported by the MHB MagyarTudomanyert Foundation and the OTKA Foundation of the Hungarian Government. ","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","oa_version":"None","quality_controlled":"1","publist_id":"4328","volume":381,"date_updated":"2022-08-11T14:45:35Z","article_processing_charge":"No","abstract":[{"text":"The probability of synaptic neurotransmitter release from nerve terminals is regulated by presynaptic receptors responding to transmitters released from the same nerve terminal or from terminals of other neurons. The release of glutamate, the major excitatory neurotransmitter, is suppressed by presynaptic auto receptors. Here we show that a metabotropic glutamate receptor (mGluR7) in the rat hippocampus is restricted to the presynaptic grid, the site of synaptic vesicle fusion. Pyramidal cell terminals presynaptic to mGluR1α-expressing interneurons have at least a ten-fold higher level of presynaptic mGluR7 than terminals making synapses with pyramidal cells and other types of interneuron. Distinct levels of mGluR7 are found at different synapses made by individual pyramidal axons or even single boutons. These results raise the possibility that presynaptic neurons could regulate the probability of transmitter release at individual synapses according to the postsynaptic target","lang":"eng"}],"author":[{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","first_name":"Ryuichi"},{"first_name":"Ákos","last_name":"Kulik","full_name":"Kulik, Ákos"},{"last_name":"Roberts","full_name":"Roberts, John","first_name":"John"},{"first_name":"Hitoshi","last_name":"Ohishi","full_name":"Ohishi, Hitoshi"},{"last_name":"Nusser","full_name":"Nusser, Zoltán","first_name":"Zoltán"},{"first_name":"Takeshi","full_name":"Kaneko, Takeshi","last_name":"Kaneko"},{"first_name":"Péter","last_name":"Somogyi","full_name":"Somogyi, Péter"}],"publication_status":"published","citation":{"apa":"Shigemoto, R., Kulik, Á., Roberts, J., Ohishi, H., Nusser, Z., Kaneko, T., &#38; Somogyi, P. (1996). Target-cell-specific concentration of a metabotropic glutamate receptor in the presynaptic active zone. <i>Nature</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/381523a0\">https://doi.org/10.1038/381523a0</a>","ieee":"R. Shigemoto <i>et al.</i>, “Target-cell-specific concentration of a metabotropic glutamate receptor in the presynaptic active zone,” <i>Nature</i>, vol. 381, no. 6582. Nature Publishing Group, pp. 523–525, 1996.","chicago":"Shigemoto, Ryuichi, Ákos Kulik, John Roberts, Hitoshi Ohishi, Zoltán Nusser, Takeshi Kaneko, and Péter Somogyi. “Target-Cell-Specific Concentration of a Metabotropic Glutamate Receptor in the Presynaptic Active Zone.” <i>Nature</i>. Nature Publishing Group, 1996. <a href=\"https://doi.org/10.1038/381523a0\">https://doi.org/10.1038/381523a0</a>.","mla":"Shigemoto, Ryuichi, et al. “Target-Cell-Specific Concentration of a Metabotropic Glutamate Receptor in the Presynaptic Active Zone.” <i>Nature</i>, vol. 381, no. 6582, Nature Publishing Group, 1996, pp. 523–25, doi:<a href=\"https://doi.org/10.1038/381523a0\">10.1038/381523a0</a>.","ama":"Shigemoto R, Kulik Á, Roberts J, et al. Target-cell-specific concentration of a metabotropic glutamate receptor in the presynaptic active zone. <i>Nature</i>. 1996;381(6582):523-525. doi:<a href=\"https://doi.org/10.1038/381523a0\">10.1038/381523a0</a>","ista":"Shigemoto R, Kulik Á, Roberts J, Ohishi H, Nusser Z, Kaneko T, Somogyi P. 1996. Target-cell-specific concentration of a metabotropic glutamate receptor in the presynaptic active zone. Nature. 381(6582), 523–525.","short":"R. Shigemoto, Á. Kulik, J. Roberts, H. Ohishi, Z. Nusser, T. Kaneko, P. Somogyi, Nature 381 (1996) 523–525."},"external_id":{"pmid":["8632825 "]},"title":"Target-cell-specific concentration of a metabotropic glutamate receptor in the presynaptic active zone","year":"1996","doi":"10.1038/381523a0","issue":"6582","publication":"Nature","page":"523 - 525","intvolume":"       381","status":"public","day":"06","type":"journal_article","date_created":"2018-12-11T11:58:26Z","publisher":"Nature Publishing Group","scopus_import":"1","language":[{"iso":"eng"}],"month":"06","article_type":"original","date_published":"1996-06-06T00:00:00Z"},{"date_created":"2018-12-11T12:04:09Z","main_file_link":[{"url":"https://www.nature.com/articles/377388a0"}],"external_id":{"pmid":["7566112 "]},"title":"Déjà vu all over again","publisher":"Nature Publishing Group","language":[{"iso":"eng"}],"month":"10","year":"1995","doi":"10.1038/377388a0","date_published":"1995-10-05T00:00:00Z","publication_identifier":{"issn":["0028-0836"]},"extern":"1","_id":"3597","pmid":1,"quality_controlled":"1","oa_version":"None","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication":"Nature","article_processing_charge":"No","page":"388 - 389","publist_id":"2786","date_updated":"2022-06-27T13:00:10Z","volume":377,"intvolume":"       377","author":[{"first_name":"Mark","full_name":"Kirkpatrick, Mark","last_name":"Kirkpatrick"},{"orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H","last_name":"Barton","first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"}],"status":"public","day":"05","citation":{"apa":"Kirkpatrick, M., &#38; Barton, N. H. (1995). Déjà vu all over again. <i>Nature</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/377388a0\">https://doi.org/10.1038/377388a0</a>","ieee":"M. Kirkpatrick and N. H. Barton, “Déjà vu all over again,” <i>Nature</i>, vol. 377. Nature Publishing Group, pp. 388–389, 1995.","chicago":"Kirkpatrick, Mark, and Nicholas H Barton. “Déjà vu All over Again.” <i>Nature</i>. Nature Publishing Group, 1995. <a href=\"https://doi.org/10.1038/377388a0\">https://doi.org/10.1038/377388a0</a>.","ama":"Kirkpatrick M, Barton NH. Déjà vu all over again. <i>Nature</i>. 1995;377:388-389. doi:<a href=\"https://doi.org/10.1038/377388a0\">10.1038/377388a0</a>","mla":"Kirkpatrick, Mark, and Nicholas H. Barton. “Déjà vu All over Again.” <i>Nature</i>, vol. 377, Nature Publishing Group, 1995, pp. 388–89, doi:<a href=\"https://doi.org/10.1038/377388a0\">10.1038/377388a0</a>.","ista":"Kirkpatrick M, Barton NH. 1995. Déjà vu all over again. Nature. 377, 388–389.","short":"M. Kirkpatrick, N.H. Barton, Nature 377 (1995) 388–389."},"publication_status":"published","type":"review"},{"date_published":"1993-01-01T00:00:00Z","article_type":"original","month":"01","language":[{"iso":"eng"}],"scopus_import":"1","publisher":"Nature Publishing Group","date_created":"2018-12-11T11:58:18Z","type":"journal_article","day":"01","status":"public","intvolume":"       366","page":"687 - 690","publication":"Nature","issue":"6456","year":"1993","doi":"10.1038/366687a0","external_id":{"pmid":["7903116 "]},"title":"Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb","main_file_link":[{"url":"https://www.nature.com/articles/366687a0"}],"citation":{"mla":"Hayashi, Yasunori, et al. “Role of a Metabotropic Glutamate Receptor in Synaptic Modulation in the Accessory Olfactory Bulb.” <i>Nature</i>, vol. 366, no. 6456, Nature Publishing Group, 1993, pp. 687–90, doi:<a href=\"https://doi.org/10.1038/366687a0\">10.1038/366687a0</a>.","ama":"Hayashi Y, Momiyama A, Takahashi T, et al. Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb. <i>Nature</i>. 1993;366(6456):687-690. doi:<a href=\"https://doi.org/10.1038/366687a0\">10.1038/366687a0</a>","ista":"Hayashi Y, Momiyama A, Takahashi T, Ohishi H, Ogawa Meguro R, Shigemoto R, Mizuno N, Nakanishi S. 1993. Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb. Nature. 366(6456), 687–690.","short":"Y. Hayashi, A. Momiyama, T. Takahashi, H. Ohishi, R. Ogawa Meguro, R. Shigemoto, N. Mizuno, S. Nakanishi, Nature 366 (1993) 687–690.","apa":"Hayashi, Y., Momiyama, A., Takahashi, T., Ohishi, H., Ogawa Meguro, R., Shigemoto, R., … Nakanishi, S. (1993). Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb. <i>Nature</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/366687a0\">https://doi.org/10.1038/366687a0</a>","ieee":"Y. Hayashi <i>et al.</i>, “Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb,” <i>Nature</i>, vol. 366, no. 6456. Nature Publishing Group, pp. 687–690, 1993.","chicago":"Hayashi, Yasunori, Akiko Momiyama, Tomoyuki Takahashi, Hitoshi Ohishi, Reiko Ogawa Meguro, Ryuichi Shigemoto, Noboru Mizuno, and Shigetada Nakanishi. “Role of a Metabotropic Glutamate Receptor in Synaptic Modulation in the Accessory Olfactory Bulb.” <i>Nature</i>. Nature Publishing Group, 1993. <a href=\"https://doi.org/10.1038/366687a0\">https://doi.org/10.1038/366687a0</a>."},"publication_status":"published","author":[{"first_name":"Yasunori","full_name":"Hayashi, Yasunori","last_name":"Hayashi"},{"full_name":"Momiyama, Akiko","last_name":"Momiyama","first_name":"Akiko"},{"first_name":"Tomoyuki","full_name":"Takahashi, Tomoyuki","last_name":"Takahashi"},{"first_name":"Hitoshi","full_name":"Ohishi, Hitoshi","last_name":"Ohishi"},{"last_name":"Ogawa Meguro","full_name":"Ogawa Meguro, Reiko","first_name":"Reiko"},{"first_name":"Ryuichi","full_name":"Shigemoto, Ryuichi","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Mizuno","full_name":"Mizuno, Noboru","first_name":"Noboru"},{"first_name":"Shigetada","last_name":"Nakanishi","full_name":"Nakanishi, Shigetada"}],"abstract":[{"text":"VARIOUS functions of glutamate transmission are mediated by both ionotropic and metabotropic glutamate receptors1. The metabotropic glutamate receptors (mGluRs) consist of at least six different subtypes that are classified into three subgroups, mGluR1/mGluR5, mGluR2/mGluR3, and mGluR4/mGluR6 (refs 1-5), but their physiological roles are largely unknown. Here we report the identification of a very potent agonist for mGluR2/mGluR3, DCG-IV, and the specific localization of mGluR2 in granule cell dendrites that form dendrodendritic synapses with mitral cells in the accessory olfactory bulb. Using the DCG-IV agonist for mGluR2 in combination with slice patchrecording, we demonstrate that the granule cell mGluR2 presynaptically suppresses inhibitory GABA (γ-aminobutyrate) transmission to the mitral cell. Our results indicate that mGluR2 in granule cells plays an important role in the persistent excitation of olfactory sensory transmission in the accessory olfactory bulb by relieving mitral cells from the GABA inhibition.","lang":"eng"}],"article_processing_charge":"No","volume":366,"date_updated":"2022-03-31T09:36:00Z","publist_id":"4354","oa_version":"None","quality_controlled":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","acknowledgement":"We thank Y. Ohfune and K. Shimamoto for DCG-IV, M. Kuno for advice and A. Uesugi for photographic assistance. Partly supported by research grants from the Ministry of Education, Science and Culture of Japan, the Ministry of Health and Welfare of Japan and the Senri Life Science Foundation. ","publication_identifier":{"issn":["0028-0836"]},"extern":"1","_id":"2544","pmid":1},{"article_processing_charge":"No","date_updated":"2022-03-24T12:22:38Z","volume":362,"publist_id":"1766","extern":"1","publication_identifier":{"issn":["0028-0836"]},"_id":"4300","pmid":1,"quality_controlled":"1","oa_version":"None","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","acknowledgement":"We thank B. Charlesworth, T. Chapman. K. Dawson, K. S. Gale. P. Harvey. A. Kondrashov. J. Maynard Smith, M. J. Morgan, M. Slatkin and M. Turell/ for helpful comments and C. Roper for providing the data for Fig. 1. Our work was supported by grants from the NERC and SERC and by the Darwin Trust of Edinburgh.","citation":{"ieee":"L. Partridge and N. H. Barton, “Optimality, mutation and the evolution of ageing,” <i>Nature</i>, vol. 362. Nature Publishing Group, pp. 305–311, 1993.","apa":"Partridge, L., &#38; Barton, N. H. (1993). Optimality, mutation and the evolution of ageing. <i>Nature</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/362305a0\">https://doi.org/10.1038/362305a0</a>","chicago":"Partridge, Linda, and Nicholas H Barton. “Optimality, Mutation and the Evolution of Ageing.” <i>Nature</i>. Nature Publishing Group, 1993. <a href=\"https://doi.org/10.1038/362305a0\">https://doi.org/10.1038/362305a0</a>.","mla":"Partridge, Linda, and Nicholas H. Barton. “Optimality, Mutation and the Evolution of Ageing.” <i>Nature</i>, vol. 362, Nature Publishing Group, 1993, pp. 305–11, doi:<a href=\"https://doi.org/10.1038/362305a0\">10.1038/362305a0</a>.","ama":"Partridge L, Barton NH. Optimality, mutation and the evolution of ageing. <i>Nature</i>. 1993;362:305-311. doi:<a href=\"https://doi.org/10.1038/362305a0\">10.1038/362305a0</a>","ista":"Partridge L, Barton NH. 1993. Optimality, mutation and the evolution of ageing. Nature. 362, 305–311.","short":"L. Partridge, N.H. Barton, Nature 362 (1993) 305–311."},"publication_status":"published","abstract":[{"text":"Evolutionary explanations of ageing fall into two classes. Organisms might have evolved the optimal life history, in which survival and fertility late in life are sacrificed for the sake of early reproduction and survival. Alternatively, the life history might be depressed below this optimal compromise by deleterious mutations: because selection against late-acting mutations is weaker, these will impose a greater load on late life. Evidence for the importance of both is emerging, and unravelling their relative importance presents experimentalists with a major challenge.","lang":"eng"}],"author":[{"first_name":"Linda","last_name":"Partridge","full_name":"Partridge, Linda"},{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","full_name":"Barton, Nicholas H","last_name":"Barton","orcid":"0000-0002-8548-5240","first_name":"Nicholas H"}],"main_file_link":[{"url":"https://www.nature.com/articles/362305a0"}],"year":"1993","doi":"10.1038/362305a0","external_id":{"pmid":["8455716"]},"title":"Optimality, mutation and the evolution of ageing","publication":"Nature","page":"305 - 311","day":"25","type":"journal_article","intvolume":"       362","status":"public","date_created":"2018-12-11T12:08:07Z","month":"03","date_published":"1993-03-25T00:00:00Z","article_type":"original","publisher":"Nature Publishing Group","language":[{"iso":"eng"}]},{"external_id":{"pmid":["1847995 "]},"title":"Sequence and expression of a metabotropic glutamate receptor","doi":"10.1038/349760a0","year":"1991","main_file_link":[{"url":"https://www.nature.com/articles/349760a0"}],"abstract":[{"text":"The complementary DNA of a metabotropic glutamate receptor coupled to inositol phosphate/Ca2+ signal transduction has been cloned and characterized. This receptor shows no sequence similarity to conventional G protein-coupled receptors and has a unique structure with large hydrophilic sequences at both sides of seven putative membrane-spanning domains. Abundant expression of this messenger RNA is observed in neuronal cells in hippocampal dentate gyrus and CA2-3 and in cerebellar Purkinje cells, suggesting the importance of this receptor in specific hippocampal and cerebellar functions.","lang":"eng"}],"author":[{"first_name":"Masayuki","last_name":"Masu","full_name":"Masu, Masayuki"},{"full_name":"Tanabe, Yasuto","last_name":"Tanabe","first_name":"Yasuto"},{"last_name":"Tsuchida","full_name":"Tsuchida, Kunihiro","first_name":"Kunihiro"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi"},{"first_name":"Shigetada","last_name":"Nakanishi","full_name":"Nakanishi, Shigetada"}],"citation":{"chicago":"Masu, Masayuki, Yasuto Tanabe, Kunihiro Tsuchida, Ryuichi Shigemoto, and Shigetada Nakanishi. “Sequence and Expression of a Metabotropic Glutamate Receptor.” <i>Nature</i>. Nature Publishing Group, 1991. <a href=\"https://doi.org/10.1038/349760a0\">https://doi.org/10.1038/349760a0</a>.","apa":"Masu, M., Tanabe, Y., Tsuchida, K., Shigemoto, R., &#38; Nakanishi, S. (1991). Sequence and expression of a metabotropic glutamate receptor. <i>Nature</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/349760a0\">https://doi.org/10.1038/349760a0</a>","ieee":"M. Masu, Y. Tanabe, K. Tsuchida, R. Shigemoto, and S. Nakanishi, “Sequence and expression of a metabotropic glutamate receptor,” <i>Nature</i>, vol. 349, no. 6312. Nature Publishing Group, pp. 760–765, 1991.","ista":"Masu M, Tanabe Y, Tsuchida K, Shigemoto R, Nakanishi S. 1991. Sequence and expression of a metabotropic glutamate receptor. Nature. 349(6312), 760–765.","short":"M. Masu, Y. Tanabe, K. Tsuchida, R. Shigemoto, S. Nakanishi, Nature 349 (1991) 760–765.","ama":"Masu M, Tanabe Y, Tsuchida K, Shigemoto R, Nakanishi S. Sequence and expression of a metabotropic glutamate receptor. <i>Nature</i>. 1991;349(6312):760-765. doi:<a href=\"https://doi.org/10.1038/349760a0\">10.1038/349760a0</a>","mla":"Masu, Masayuki, et al. “Sequence and Expression of a Metabotropic Glutamate Receptor.” <i>Nature</i>, vol. 349, no. 6312, Nature Publishing Group, 1991, pp. 760–65, doi:<a href=\"https://doi.org/10.1038/349760a0\">10.1038/349760a0</a>."},"publication_status":"published","extern":"1","publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"_id":"2482","pmid":1,"oa_version":"None","quality_controlled":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","publist_id":"4419","date_updated":"2022-03-03T15:37:36Z","volume":349,"scopus_import":"1","publisher":"Nature Publishing Group","language":[{"iso":"eng"}],"month":"02","article_type":"original","date_published":"1991-02-28T00:00:00Z","date_created":"2018-12-11T11:57:55Z","intvolume":"       349","status":"public","day":"28","type":"journal_article","publication":"Nature","issue":"6312","page":"760 - 765"},{"main_file_link":[{"url":"https://www.nature.com/articles/354031a0"}],"doi":"10.1038/354031a0","year":"1991","title":"Molecular cloning and characterization of the rat NMDA receptor","external_id":{"pmid":["1834949"]},"publist_id":"4418","date_updated":"2022-03-03T15:25:04Z","volume":353,"article_processing_charge":"No","_id":"2483","pmid":1,"extern":"1","publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","oa_version":"None","quality_controlled":"1","publication_status":"published","citation":{"mla":"Moriyoshi, Koki, et al. “Molecular Cloning and Characterization of the Rat NMDA Receptor.” <i>Nature</i>, vol. 353, no. 6348, Nature Publishing Group, 1991, pp. 31–37, doi:<a href=\"https://doi.org/10.1038/354031a0\">10.1038/354031a0</a>.","ama":"Moriyoshi K, Masu M, Ishii T, Shigemoto R, Mizuno N, Nakanishi S. Molecular cloning and characterization of the rat NMDA receptor. <i>Nature</i>. 1991;353(6348):31-37. doi:<a href=\"https://doi.org/10.1038/354031a0\">10.1038/354031a0</a>","short":"K. Moriyoshi, M. Masu, T. Ishii, R. Shigemoto, N. Mizuno, S. Nakanishi, Nature 353 (1991) 31–37.","ista":"Moriyoshi K, Masu M, Ishii T, Shigemoto R, Mizuno N, Nakanishi S. 1991. Molecular cloning and characterization of the rat NMDA receptor. Nature. 353(6348), 31–37.","apa":"Moriyoshi, K., Masu, M., Ishii, T., Shigemoto, R., Mizuno, N., &#38; Nakanishi, S. (1991). Molecular cloning and characterization of the rat NMDA receptor. <i>Nature</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/354031a0\">https://doi.org/10.1038/354031a0</a>","ieee":"K. Moriyoshi, M. Masu, T. Ishii, R. Shigemoto, N. Mizuno, and S. Nakanishi, “Molecular cloning and characterization of the rat NMDA receptor,” <i>Nature</i>, vol. 353, no. 6348. Nature Publishing Group, pp. 31–37, 1991.","chicago":"Moriyoshi, Koki, Masayuki Masu, Takahiro Ishii, Ryuichi Shigemoto, Noboru Mizuno, and Shigetada Nakanishi. “Molecular Cloning and Characterization of the Rat NMDA Receptor.” <i>Nature</i>. Nature Publishing Group, 1991. <a href=\"https://doi.org/10.1038/354031a0\">https://doi.org/10.1038/354031a0</a>."},"abstract":[{"lang":"eng","text":"A complementary DNA encoding the rat NMDA receptor has been cloned and characterized. The single protein encoded by the cDNA forms a receptor-channel complex that has electrophysiological and pharmacological properties characteristic of the NMDA receptor. This protein has a significant sequence similarity to the AMPA/kainate receptors and contains four putative transmembrane segments following a large extracellular domain. The NMDA receptor messenger RNA is expressed in neuronal cells throughout the brain regions, particularly in the hippocampus, cerebral cortex and cerebellum."}],"author":[{"first_name":"Koki","last_name":"Moriyoshi","full_name":"Moriyoshi, Koki"},{"first_name":"Masayuki","full_name":"Masu, Masayuki","last_name":"Masu"},{"full_name":"Ishii, Takahiro","last_name":"Ishii","first_name":"Takahiro"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi","last_name":"Shigemoto","first_name":"Ryuichi"},{"last_name":"Mizuno","full_name":"Mizuno, Noboru","first_name":"Noboru"},{"first_name":"Shigetada","last_name":"Nakanishi","full_name":"Nakanishi, Shigetada"}],"date_created":"2018-12-11T11:57:56Z","month":"11","article_type":"original","date_published":"1991-11-07T00:00:00Z","publisher":"Nature Publishing Group","scopus_import":"1","language":[{"iso":"eng"}],"issue":"6348","publication":"Nature","page":"31 - 37","day":"07","type":"journal_article","intvolume":"       353","status":"public"},{"language":[{"iso":"eng"}],"title":"The language of the genes","scopus_import":"1","publisher":"Nature Publishing Group","article_type":"original","date_published":"1990-08-02T00:00:00Z","month":"08","year":"1990","doi":"10.1038/346415a0","date_created":"2018-12-11T12:08:11Z","main_file_link":[{"url":"https://www.nature.com/articles/346415a0"}],"author":[{"orcid":"0000-0002-8548-5240","last_name":"Barton","full_name":"Barton, Nicholas H","first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Steve","last_name":"Jones","full_name":"Jones, Steve"}],"status":"public","intvolume":"       346","type":"journal_article","day":"02","citation":{"chicago":"Barton, Nicholas H, and Steve Jones. “The Language of the Genes.” <i>Nature</i>. 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Studies of hybrid zones allow us to quantify the genetic differences responsible for speciation, to measure the diffusion of genes between diverging taxa, and to understand the spread of alternative adaptations."}],"author":[{"orcid":"0000-0002-8548-5240","last_name":"Barton","full_name":"Barton, Nicholas H","first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Hewitt","full_name":"Hewitt, Godfrey","first_name":"Godfrey"}],"publication_status":"published","citation":{"short":"N.H. Barton, G. Hewitt, Nature 341 (1989) 497–503.","ista":"Barton NH, Hewitt G. 1989. Adaptation, speciation and hybrid zones. Nature. 341, 497–503.","mla":"Barton, Nicholas H., and Godfrey Hewitt. “Adaptation, Speciation and Hybrid Zones.” <i>Nature</i>, vol. 341, Nature Publishing Group, 1989, pp. 497–503, doi:<a href=\"https://doi.org/10.1038/341497a0\">10.1038/341497a0</a>.","ama":"Barton NH, Hewitt G. 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