@misc{4283,
  author       = {Barton, Nicholas H},
  booktitle    = {Nature},
  issn         = {0028-0836},
  number       = {6704},
  pages        = {751 -- 752},
  publisher    = {Nature Publishing Group},
  title        = {{The geometry of adaptation}},
  doi          = {10.1038/27338},
  volume       = {395},
  year         = {1998},
}

@article{2570,
  abstract     = {The probability of synaptic neurotransmitter release from nerve terminals is regulated by presynaptic receptors responding to transmitters released from the same nerve terminal or from terminals of other neurons. The release of glutamate, the major excitatory neurotransmitter, is suppressed by presynaptic auto receptors. Here we show that a metabotropic glutamate receptor (mGluR7) in the rat hippocampus is restricted to the presynaptic grid, the site of synaptic vesicle fusion. Pyramidal cell terminals presynaptic to mGluR1α-expressing interneurons have at least a ten-fold higher level of presynaptic mGluR7 than terminals making synapses with pyramidal cells and other types of interneuron. Distinct levels of mGluR7 are found at different synapses made by individual pyramidal axons or even single boutons. These results raise the possibility that presynaptic neurons could regulate the probability of transmitter release at individual synapses according to the postsynaptic target},
  author       = {Shigemoto, Ryuichi and Kulik, Ákos and Roberts, John and Ohishi, Hitoshi and Nusser, Zoltán and Kaneko, Takeshi and Somogyi, Péter},
  issn         = {0028-0836},
  journal      = {Nature},
  number       = {6582},
  pages        = {523 -- 525},
  publisher    = {Nature Publishing Group},
  title        = {{Target-cell-specific concentration of a metabotropic glutamate receptor in the presynaptic active zone}},
  doi          = {10.1038/381523a0},
  volume       = {381},
  year         = {1996},
}

@misc{3597,
  author       = {Kirkpatrick, Mark and Barton, Nicholas H},
  booktitle    = {Nature},
  issn         = {0028-0836},
  pages        = {388 -- 389},
  publisher    = {Nature Publishing Group},
  title        = {{Déjà vu all over again}},
  doi          = {10.1038/377388a0},
  volume       = {377},
  year         = {1995},
}

@article{2544,
  abstract     = {VARIOUS functions of glutamate transmission are mediated by both ionotropic and metabotropic glutamate receptors1. The metabotropic glutamate receptors (mGluRs) consist of at least six different subtypes that are classified into three subgroups, mGluR1/mGluR5, mGluR2/mGluR3, and mGluR4/mGluR6 (refs 1-5), but their physiological roles are largely unknown. Here we report the identification of a very potent agonist for mGluR2/mGluR3, DCG-IV, and the specific localization of mGluR2 in granule cell dendrites that form dendrodendritic synapses with mitral cells in the accessory olfactory bulb. Using the DCG-IV agonist for mGluR2 in combination with slice patchrecording, we demonstrate that the granule cell mGluR2 presynaptically suppresses inhibitory GABA (γ-aminobutyrate) transmission to the mitral cell. Our results indicate that mGluR2 in granule cells plays an important role in the persistent excitation of olfactory sensory transmission in the accessory olfactory bulb by relieving mitral cells from the GABA inhibition.},
  author       = {Hayashi, Yasunori and Momiyama, Akiko and Takahashi, Tomoyuki and Ohishi, Hitoshi and Ogawa Meguro, Reiko and Shigemoto, Ryuichi and Mizuno, Noboru and Nakanishi, Shigetada},
  issn         = {0028-0836},
  journal      = {Nature},
  number       = {6456},
  pages        = {687 -- 690},
  publisher    = {Nature Publishing Group},
  title        = {{Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb}},
  doi          = {10.1038/366687a0},
  volume       = {366},
  year         = {1993},
}

@article{4300,
  abstract     = {Evolutionary explanations of ageing fall into two classes. Organisms might have evolved the optimal life history, in which survival and fertility late in life are sacrificed for the sake of early reproduction and survival. Alternatively, the life history might be depressed below this optimal compromise by deleterious mutations: because selection against late-acting mutations is weaker, these will impose a greater load on late life. Evidence for the importance of both is emerging, and unravelling their relative importance presents experimentalists with a major challenge.},
  author       = {Partridge, Linda and Barton, Nicholas H},
  issn         = {0028-0836},
  journal      = {Nature},
  pages        = {305 -- 311},
  publisher    = {Nature Publishing Group},
  title        = {{Optimality, mutation and the evolution of ageing}},
  doi          = {10.1038/362305a0},
  volume       = {362},
  year         = {1993},
}

@article{2482,
  abstract     = {The complementary DNA of a metabotropic glutamate receptor coupled to inositol phosphate/Ca2+ signal transduction has been cloned and characterized. This receptor shows no sequence similarity to conventional G protein-coupled receptors and has a unique structure with large hydrophilic sequences at both sides of seven putative membrane-spanning domains. Abundant expression of this messenger RNA is observed in neuronal cells in hippocampal dentate gyrus and CA2-3 and in cerebellar Purkinje cells, suggesting the importance of this receptor in specific hippocampal and cerebellar functions.},
  author       = {Masu, Masayuki and Tanabe, Yasuto and Tsuchida, Kunihiro and Shigemoto, Ryuichi and Nakanishi, Shigetada},
  issn         = {1476-4687},
  journal      = {Nature},
  number       = {6312},
  pages        = {760 -- 765},
  publisher    = {Nature Publishing Group},
  title        = {{Sequence and expression of a metabotropic glutamate receptor}},
  doi          = {10.1038/349760a0},
  volume       = {349},
  year         = {1991},
}

@article{2483,
  abstract     = {A complementary DNA encoding the rat NMDA receptor has been cloned and characterized. The single protein encoded by the cDNA forms a receptor-channel complex that has electrophysiological and pharmacological properties characteristic of the NMDA receptor. This protein has a significant sequence similarity to the AMPA/kainate receptors and contains four putative transmembrane segments following a large extracellular domain. The NMDA receptor messenger RNA is expressed in neuronal cells throughout the brain regions, particularly in the hippocampus, cerebral cortex and cerebellum.},
  author       = {Moriyoshi, Koki and Masu, Masayuki and Ishii, Takahiro and Shigemoto, Ryuichi and Mizuno, Noboru and Nakanishi, Shigetada},
  issn         = {1476-4687},
  journal      = {Nature},
  number       = {6348},
  pages        = {31 -- 37},
  publisher    = {Nature Publishing Group},
  title        = {{Molecular cloning and characterization of the rat NMDA receptor}},
  doi          = {10.1038/354031a0},
  volume       = {353},
  year         = {1991},
}

@article{4310,
  author       = {Barton, Nicholas H and Jones, Steve},
  issn         = {1476-4687},
  journal      = {Nature},
  pages        = {415 -- 416},
  publisher    = {Nature Publishing Group},
  title        = {{The language of the genes}},
  doi          = {10.1038/346415a0},
  volume       = {346},
  year         = {1990},
}

@article{3654,
  abstract     = {Many species are divided into a mosaic of genetically distinct populations, separated by narrow zones of hybridization. Studies of hybrid zones allow us to quantify the genetic differences responsible for speciation, to measure the diffusion of genes between diverging taxa, and to understand the spread of alternative adaptations.},
  author       = {Barton, Nicholas H and Hewitt, Godfrey},
  issn         = {1476-4687},
  journal      = {Nature},
  pages        = {497 -- 503},
  publisher    = {Nature Publishing Group},
  title        = {{Adaptation, speciation and hybrid zones}},
  doi          = {10.1038/341497a0},
  volume       = {341},
  year         = {1989},
}

@misc{4315,
  author       = {Coyne, Jerry and Barton, Nicholas H},
  booktitle    = {Nature},
  issn         = {1476-4687},
  pages        = {485 -- 486},
  publisher    = {Nature Publishing Group},
  title        = {{What do we know about speciation?}},
  doi          = {10.1038/331485a0},
  volume       = {331},
  year         = {1988},
}

@misc{4316,
  author       = {Barton, Nicholas H and Jones, Steve},
  booktitle    = {Nature},
  issn         = {1476-4687},
  pages        = {597 -- 597},
  publisher    = {Springer Nature},
  title        = {{Molecular evolutionary genetics}},
  doi          = {10.1038/332597a0},
  volume       = {332},
  year         = {1988},
}

@misc{4318,
  author       = {Barton, Nicholas H and Jones, Steve and Mallet, James},
  booktitle    = {Nature},
  issn         = {1476-4687},
  pages        = {13 -- 14},
  publisher    = {Springer Nature},
  title        = {{No barriers to speciation}},
  doi          = {10.1038/336013a0},
  volume       = {336},
  year         = {1988},
}

@article{3598,
  author       = {Barton, Nicholas H and Jones, Steve},
  issn         = {1476-4687},
  journal      = {Nature},
  pages        = {317 -- 318},
  publisher    = {Springer Nature},
  title        = {{Mitochondrial DNA: new clues about evolution}},
  doi          = {10.1038/306317a0},
  volume       = {306},
  year         = {1983},
}