---
_id: '5672'
abstract:
- lang: eng
  text: The release of IgM is the first line of an antibody response and precedes
    the generation of high affinity IgG in germinal centers. Once secreted by freshly
    activated plasmablasts, IgM is released into the efferent lymph of reactive lymph
    nodes as early as 3 d after immunization. As pentameric IgM has an enormous size
    of 1,000 kD, its diffusibility is low, and one might wonder how it can pass through
    the densely lymphocyte-packed environment of a lymph node parenchyma in order
    to reach its exit. In this issue of JEM, Thierry et al. show that, in order to
    reach the blood stream, IgM molecules take a specific micro-anatomical route via
    lymph node conduits.
article_processing_charge: No
author:
- first_name: Anne
  full_name: Reversat, Anne
  id: 35B76592-F248-11E8-B48F-1D18A9856A87
  last_name: Reversat
  orcid: 0000-0003-0666-8928
- first_name: Michael K
  full_name: Sixt, Michael K
  id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
  last_name: Sixt
  orcid: 0000-0002-6620-9179
citation:
  ama: Reversat A, Sixt MK. IgM’s exit route. <i>Journal of Experimental Medicine</i>.
    2018;215(12):2959-2961. doi:<a href="https://doi.org/10.1084/jem.20181934">10.1084/jem.20181934</a>
  apa: Reversat, A., &#38; Sixt, M. K. (2018). IgM’s exit route. <i>Journal of Experimental
    Medicine</i>. Rockefeller University Press. <a href="https://doi.org/10.1084/jem.20181934">https://doi.org/10.1084/jem.20181934</a>
  chicago: Reversat, Anne, and Michael K Sixt. “IgM’s Exit Route.” <i>Journal of Experimental
    Medicine</i>. Rockefeller University Press, 2018. <a href="https://doi.org/10.1084/jem.20181934">https://doi.org/10.1084/jem.20181934</a>.
  ieee: A. Reversat and M. K. Sixt, “IgM’s exit route,” <i>Journal of Experimental
    Medicine</i>, vol. 215, no. 12. Rockefeller University Press, pp. 2959–2961, 2018.
  ista: Reversat A, Sixt MK. 2018. IgM’s exit route. Journal of Experimental Medicine.
    215(12), 2959–2961.
  mla: Reversat, Anne, and Michael K. Sixt. “IgM’s Exit Route.” <i>Journal of Experimental
    Medicine</i>, vol. 215, no. 12, Rockefeller University Press, 2018, pp. 2959–61,
    doi:<a href="https://doi.org/10.1084/jem.20181934">10.1084/jem.20181934</a>.
  short: A. Reversat, M.K. Sixt, Journal of Experimental Medicine 215 (2018) 2959–2961.
date_created: 2018-12-16T22:59:18Z
date_published: 2018-11-20T00:00:00Z
date_updated: 2023-09-11T14:12:06Z
day: '20'
ddc:
- '570'
department:
- _id: MiSi
doi: 10.1084/jem.20181934
external_id:
  isi:
  - '000451920600002'
file:
- access_level: open_access
  checksum: 687beea1d64c213f4cb9e3c29ec11a14
  content_type: application/pdf
  creator: dernst
  date_created: 2019-02-06T08:49:52Z
  date_updated: 2020-07-14T12:47:09Z
  file_id: '5931'
  file_name: 2018_JournalExperMed_Reversat.pdf
  file_size: 1216437
  relation: main_file
file_date_updated: 2020-07-14T12:47:09Z
has_accepted_license: '1'
intvolume: '       215'
isi: 1
issue: '12'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-sa/4.0/
month: '11'
oa: 1
oa_version: Published Version
page: 2959-2961
publication: Journal of Experimental Medicine
publication_identifier:
  issn:
  - '00221007'
publication_status: published
publisher: Rockefeller University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: IgM's exit route
tmp:
  image: /images/cc_by_nc_sa.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
    BY-NC-SA 4.0)
  short: CC BY-NC-SA (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 215
year: '2018'
...