---
_id: '859'
abstract:
- lang: eng
text: The polymeric ubiquitin (poly-u) genes are composed of tandem 228-bp repeats
with no spacer sequences between individual monomer units. Ubiquitin is one of
the most conserved proteins known to date, and the individual units within a number
of poly-u genes are significantly more similar to each other than would be expected
if each unit evolved independently. It has been proposed that the rather striking
similarity among poly-u monomers in some lineages is caused by a series of homogenization
events. Here we report the sequences of the polyubiquitin-C (Ubc) genes in two
mouse strains. Analysis of these sequences, as well as those of the previously
reported Chinese hamster and rat poly-u genes, supports the assertion that the
homogenization of the ubiquitin-C gene in rodents is due to unequal crossing-over
events. The sequence divergence of noncoding DNA was used to estimate the frequency
of unequal crossing-over events (6.3 x 10-5 events per generation) in the Ubc
gene, as well as to provide evidence of apparent selection in the poly-u gene.
acknowledgement: We are thankful to J.A. Southerland and P.L. Jiang for technical
assistance in DNA sequencing, as well as to Y.I. Pavlov for helpful discussions.
This work was supported by public Health Service Research Grant AI45135 from the
Institute of Allergy and Infectious Diseases, National Institutes of Health.
article_processing_charge: No
article_type: original
author:
- first_name: Andrey
full_name: Perelygin, Andrey
last_name: Perelygin
- first_name: Fyodor
full_name: Kondrashov, Fyodor
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
- first_name: Igor
full_name: Rogozin, Igor
last_name: Rogozin
- first_name: Margo
full_name: Brinton, Margo
last_name: Brinton
citation:
ama: Perelygin A, Kondrashov F, Rogozin I, Brinton M. Evolution of the mouse polyubiquitin
C gene. Journal of Molecular Evolution. 2002;55(2):202-210. doi:10.1007/s00239-002-2318-0
apa: Perelygin, A., Kondrashov, F., Rogozin, I., & Brinton, M. (2002). Evolution
of the mouse polyubiquitin C gene. Journal of Molecular Evolution. Springer.
https://doi.org/10.1007/s00239-002-2318-0
chicago: Perelygin, Andrey, Fyodor Kondrashov, Igor Rogozin, and Margo Brinton.
“Evolution of the Mouse Polyubiquitin C Gene.” Journal of Molecular Evolution.
Springer, 2002. https://doi.org/10.1007/s00239-002-2318-0.
ieee: A. Perelygin, F. Kondrashov, I. Rogozin, and M. Brinton, “Evolution of the
mouse polyubiquitin C gene,” Journal of Molecular Evolution, vol. 55, no.
2. Springer, pp. 202–210, 2002.
ista: Perelygin A, Kondrashov F, Rogozin I, Brinton M. 2002. Evolution of the mouse
polyubiquitin C gene. Journal of Molecular Evolution. 55(2), 202–210.
mla: Perelygin, Andrey, et al. “Evolution of the Mouse Polyubiquitin C Gene.” Journal
of Molecular Evolution, vol. 55, no. 2, Springer, 2002, pp. 202–10, doi:10.1007/s00239-002-2318-0.
short: A. Perelygin, F. Kondrashov, I. Rogozin, M. Brinton, Journal of Molecular
Evolution 55 (2002) 202–210.
date_created: 2018-12-11T11:48:53Z
date_published: 2002-01-01T00:00:00Z
date_updated: 2023-07-26T12:01:34Z
day: '01'
doi: 10.1007/s00239-002-2318-0
extern: '1'
external_id:
pmid:
- '12107596'
intvolume: ' 55'
issue: '2'
language:
- iso: eng
month: '01'
oa_version: None
page: 202 - 210
pmid: 1
publication: Journal of Molecular Evolution
publication_identifier:
issn:
- 0022-2844
publication_status: published
publisher: Springer
publist_id: '6787'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Evolution of the mouse polyubiquitin C gene
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 55
year: '2002'
...
---
_id: '4229'
abstract:
- lang: eng
text: Bacteriophage of the family Leviviridae have played an important role in molecular
biology where representative species, such as Qβ and MS2, have been studied as
model systems for replication, translation, and the role of secondary structure
in gene regulation. Using nucleotide sequences from the coat and replicase genes
we present the first statistical estimate of phylogeny for the family Leviviridae
using maximum-likelihood and Bayesian estimation. Our analyses reveal that the
coliphage species are a monophyletic group consisting of two clades representing
the genera Levivirus and Allolevivirus. The Pseudomonas species PP7 diverged from
its common ancestor with the coliphage prior to the ancient split between these
genera and their subsequent diversification. Differences in genome size, gene
composition, and gene expression are shown with a high probability to have changed
along the lineage leading to the Allolevivirus through gene expansion. The change
in genome size of the Allolevivirus ancestor may have catalyzed subsequent changes
that led to their current genome organization and gene expression.
acknowledgement: "We thank Kenneth G. Karol, Andrea J. Betancourt, Daven C. Presgraves,
and Bret Larget for helpful comments and\r\nsuggestions. This work was supported
by funding from the National Science Foundation (MCB-0075404 and DEB-0075406) to
J.P.H."
article_processing_charge: No
article_type: original
author:
- first_name: Jonathan P
full_name: Bollback, Jonathan P
id: 2C6FA9CC-F248-11E8-B48F-1D18A9856A87
last_name: Bollback
orcid: 0000-0002-4624-4612
- first_name: John
full_name: Huelsenbeck, John
last_name: Huelsenbeck
citation:
ama: Bollback JP, Huelsenbeck J. Phylogeny, genome evolution, and host specificity
of single-stranded RNA bacteriophage (Family Leviviridae). Journal of Molecular
Evolution. 2001;52(2):117-128. doi:10.1007/s002390010140
apa: Bollback, J. P., & Huelsenbeck, J. (2001). Phylogeny, genome evolution,
and host specificity of single-stranded RNA bacteriophage (Family Leviviridae).
Journal of Molecular Evolution. Springer. https://doi.org/10.1007/s002390010140
chicago: Bollback, Jonathan P, and John Huelsenbeck. “Phylogeny, Genome Evolution,
and Host Specificity of Single-Stranded RNA Bacteriophage (Family Leviviridae).”
Journal of Molecular Evolution. Springer, 2001. https://doi.org/10.1007/s002390010140.
ieee: J. P. Bollback and J. Huelsenbeck, “Phylogeny, genome evolution, and host
specificity of single-stranded RNA bacteriophage (Family Leviviridae),” Journal
of Molecular Evolution, vol. 52, no. 2. Springer, pp. 117–128, 2001.
ista: Bollback JP, Huelsenbeck J. 2001. Phylogeny, genome evolution, and host specificity
of single-stranded RNA bacteriophage (Family Leviviridae). Journal of Molecular
Evolution. 52(2), 117–128.
mla: Bollback, Jonathan P., and John Huelsenbeck. “Phylogeny, Genome Evolution,
and Host Specificity of Single-Stranded RNA Bacteriophage (Family Leviviridae).”
Journal of Molecular Evolution, vol. 52, no. 2, Springer, 2001, pp. 117–28,
doi:10.1007/s002390010140.
short: J.P. Bollback, J. Huelsenbeck, Journal of Molecular Evolution 52 (2001) 117–128.
date_created: 2018-12-11T12:07:43Z
date_published: 2001-02-01T00:00:00Z
date_updated: 2023-05-10T12:23:49Z
day: '01'
doi: 10.1007/s002390010140
extern: '1'
external_id:
pmid:
- '11231891'
intvolume: ' 52'
issue: '2'
language:
- iso: eng
month: '02'
oa_version: None
page: 117 - 128
pmid: 1
publication: Journal of Molecular Evolution
publication_identifier:
issn:
- 0022-2844
publication_status: published
publisher: Springer
publist_id: '1886'
quality_controlled: '1'
status: public
title: Phylogeny, genome evolution, and host specificity of single-stranded RNA bacteriophage
(Family Leviviridae)
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 52
year: '2001'
...