[{"publication_status":"published","volume":55,"issue":"2","article_processing_charge":"No","_id":"859","abstract":[{"lang":"eng","text":"The polymeric ubiquitin (poly-u) genes are composed of tandem 228-bp repeats with no spacer sequences between individual monomer units. Ubiquitin is one of the most conserved proteins known to date, and the individual units within a number of poly-u genes are significantly more similar to each other than would be expected if each unit evolved independently. It has been proposed that the rather striking similarity among poly-u monomers in some lineages is caused by a series of homogenization events. Here we report the sequences of the polyubiquitin-C (Ubc) genes in two mouse strains. Analysis of these sequences, as well as those of the previously reported Chinese hamster and rat poly-u genes, supports the assertion that the homogenization of the ubiquitin-C gene in rodents is due to unequal crossing-over events. The sequence divergence of noncoding DNA was used to estimate the frequency of unequal crossing-over events (6.3 x 10-5 events per generation) in the Ubc gene, as well as to provide evidence of apparent selection in the poly-u gene."}],"date_published":"2002-01-01T00:00:00Z","date_updated":"2023-07-26T12:01:34Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","scopus_import":"1","external_id":{"pmid":["12107596"]},"publication_identifier":{"issn":["0022-2844"]},"publist_id":"6787","article_type":"original","year":"2002","oa_version":"None","publisher":"Springer","quality_controlled":"1","publication":"Journal of Molecular Evolution","intvolume":"        55","status":"public","page":"202 - 210","extern":"1","month":"01","date_created":"2018-12-11T11:48:53Z","acknowledgement":"We are thankful to J.A. Southerland and P.L. Jiang for technical assistance in DNA sequencing, as well as to Y.I. Pavlov for helpful discussions. This work was supported by public Health Service Research Grant AI45135 from the Institute of Allergy and Infectious Diseases, National Institutes of Health.","pmid":1,"language":[{"iso":"eng"}],"doi":"10.1007/s00239-002-2318-0","citation":{"mla":"Perelygin, Andrey, et al. “Evolution of the Mouse Polyubiquitin C Gene.” <i>Journal of Molecular Evolution</i>, vol. 55, no. 2, Springer, 2002, pp. 202–10, doi:<a href=\"https://doi.org/10.1007/s00239-002-2318-0\">10.1007/s00239-002-2318-0</a>.","ieee":"A. Perelygin, F. Kondrashov, I. Rogozin, and M. Brinton, “Evolution of the mouse polyubiquitin C gene,” <i>Journal of Molecular Evolution</i>, vol. 55, no. 2. Springer, pp. 202–210, 2002.","ista":"Perelygin A, Kondrashov F, Rogozin I, Brinton M. 2002. Evolution of the mouse polyubiquitin C gene. Journal of Molecular Evolution. 55(2), 202–210.","chicago":"Perelygin, Andrey, Fyodor Kondrashov, Igor Rogozin, and Margo Brinton. “Evolution of the Mouse Polyubiquitin C Gene.” <i>Journal of Molecular Evolution</i>. Springer, 2002. <a href=\"https://doi.org/10.1007/s00239-002-2318-0\">https://doi.org/10.1007/s00239-002-2318-0</a>.","apa":"Perelygin, A., Kondrashov, F., Rogozin, I., &#38; Brinton, M. (2002). Evolution of the mouse polyubiquitin C gene. <i>Journal of Molecular Evolution</i>. Springer. <a href=\"https://doi.org/10.1007/s00239-002-2318-0\">https://doi.org/10.1007/s00239-002-2318-0</a>","ama":"Perelygin A, Kondrashov F, Rogozin I, Brinton M. Evolution of the mouse polyubiquitin C gene. <i>Journal of Molecular Evolution</i>. 2002;55(2):202-210. doi:<a href=\"https://doi.org/10.1007/s00239-002-2318-0\">10.1007/s00239-002-2318-0</a>","short":"A. Perelygin, F. Kondrashov, I. Rogozin, M. Brinton, Journal of Molecular Evolution 55 (2002) 202–210."},"title":"Evolution of the mouse polyubiquitin C gene","day":"01","type":"journal_article","author":[{"last_name":"Perelygin","first_name":"Andrey","full_name":"Perelygin, Andrey"},{"full_name":"Kondrashov, Fyodor","first_name":"Fyodor","last_name":"Kondrashov","id":"44FDEF62-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8243-4694"},{"last_name":"Rogozin","full_name":"Rogozin, Igor","first_name":"Igor"},{"full_name":"Brinton, Margo","first_name":"Margo","last_name":"Brinton"}]},{"language":[{"iso":"eng"}],"doi":"10.1007/s002390010140","acknowledgement":"We thank Kenneth G. Karol, Andrea J. Betancourt, Daven C. Presgraves, and Bret Larget for helpful comments and\r\nsuggestions. This work was supported by funding from the National Science Foundation (MCB-0075404 and DEB-0075406) to J.P.H.","pmid":1,"day":"01","type":"journal_article","author":[{"orcid":"0000-0002-4624-4612","id":"2C6FA9CC-F248-11E8-B48F-1D18A9856A87","last_name":"Bollback","full_name":"Bollback, Jonathan P","first_name":"Jonathan P"},{"last_name":"Huelsenbeck","first_name":"John","full_name":"Huelsenbeck, John"}],"citation":{"ieee":"J. P. Bollback and J. Huelsenbeck, “Phylogeny, genome evolution, and host specificity of single-stranded RNA bacteriophage (Family Leviviridae),” <i>Journal of Molecular Evolution</i>, vol. 52, no. 2. Springer, pp. 117–128, 2001.","ista":"Bollback JP, Huelsenbeck J. 2001. Phylogeny, genome evolution, and host specificity of single-stranded RNA bacteriophage (Family Leviviridae). Journal of Molecular Evolution. 52(2), 117–128.","chicago":"Bollback, Jonathan P, and John Huelsenbeck. “Phylogeny, Genome Evolution, and Host Specificity of Single-Stranded RNA Bacteriophage (Family Leviviridae).” <i>Journal of Molecular Evolution</i>. Springer, 2001. <a href=\"https://doi.org/10.1007/s002390010140\">https://doi.org/10.1007/s002390010140</a>.","mla":"Bollback, Jonathan P., and John Huelsenbeck. “Phylogeny, Genome Evolution, and Host Specificity of Single-Stranded RNA Bacteriophage (Family Leviviridae).” <i>Journal of Molecular Evolution</i>, vol. 52, no. 2, Springer, 2001, pp. 117–28, doi:<a href=\"https://doi.org/10.1007/s002390010140\">10.1007/s002390010140</a>.","short":"J.P. Bollback, J. Huelsenbeck, Journal of Molecular Evolution 52 (2001) 117–128.","apa":"Bollback, J. P., &#38; Huelsenbeck, J. (2001). Phylogeny, genome evolution, and host specificity of single-stranded RNA bacteriophage (Family Leviviridae). <i>Journal of Molecular Evolution</i>. Springer. <a href=\"https://doi.org/10.1007/s002390010140\">https://doi.org/10.1007/s002390010140</a>","ama":"Bollback JP, Huelsenbeck J. Phylogeny, genome evolution, and host specificity of single-stranded RNA bacteriophage (Family Leviviridae). <i>Journal of Molecular Evolution</i>. 2001;52(2):117-128. doi:<a href=\"https://doi.org/10.1007/s002390010140\">10.1007/s002390010140</a>"},"title":"Phylogeny, genome evolution, and host specificity of single-stranded RNA bacteriophage (Family Leviviridae)","quality_controlled":"1","publication":"Journal of Molecular Evolution","status":"public","intvolume":"        52","publisher":"Springer","extern":"1","month":"02","date_created":"2018-12-11T12:07:43Z","page":"117 - 128","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_updated":"2023-05-10T12:23:49Z","external_id":{"pmid":["11231891"]},"publication_identifier":{"issn":["0022-2844"]},"publist_id":"1886","article_type":"original","year":"2001","oa_version":"None","volume":52,"publication_status":"published","_id":"4229","abstract":[{"lang":"eng","text":"Bacteriophage of the family Leviviridae have played an important role in molecular biology where representative species, such as Qβ and MS2, have been studied as model systems for replication, translation, and the role of secondary structure in gene regulation. Using nucleotide sequences from the coat and replicase genes we present the first statistical estimate of phylogeny for the family Leviviridae using maximum-likelihood and Bayesian estimation. Our analyses reveal that the coliphage species are a monophyletic group consisting of two clades representing the genera Levivirus and Allolevivirus. The Pseudomonas species PP7 diverged from its common ancestor with the coliphage prior to the ancient split between these genera and their subsequent diversification. Differences in genome size, gene composition, and gene expression are shown with a high probability to have changed along the lineage leading to the Allolevivirus through gene expansion. The change in genome size of the Allolevivirus ancestor may have catalyzed subsequent changes that led to their current genome organization and gene expression."}],"date_published":"2001-02-01T00:00:00Z","issue":"2","article_processing_charge":"No"}]