---
_id: '1019'
abstract:
- lang: eng
  text: As a consequence of its difference in copy number between males and females,
    the X chromosome is subject to unique evolutionary forces and gene regulatory
    mechanisms. Previous studies of Drosophila melanogaster have shown that the expression
    of X-linked, testis-specific reporter genes is suppressed in the male germline.
    However, it is not known whether this phenomenon is restricted to testis-expressed
    genes or if it is a more general property of genes with tissue-specific expression,
    which are also underrepresented on the X chromosome. To test this, we compared
    the expression of three tissue-specific reporter genes (ovary, accessory gland
    and Malpighian tubule) inserted at various autosomal and X-chromosomal locations.
    In contrast to testis-specific reporter genes, we found no reduction of X-linked
    expression in any of the other tissues. In accessory gland and Malpighian tubule,
    we detected higher expression of the X-linked reporter genes, which suggests that
    they are at least partially dosage compensated. We found no difference in the
    tissue-specificity of X-linked and autosomal reporter genes. These findings indicate
    that, in general, the X chromosome is not a detrimental environment for tissue-specific
    gene expression and that the suppression of X-linked expression is limited to
    the male germline.
article_processing_charge: No
author:
- first_name: Eliza
  full_name: Argyridou, Eliza
  last_name: Argyridou
- first_name: Ann K
  full_name: Huylmans, Ann K
  id: 4C0A3874-F248-11E8-B48F-1D18A9856A87
  last_name: Huylmans
  orcid: 0000-0001-8871-4961
- first_name: Annabella
  full_name: Königer, Annabella
  last_name: Königer
- first_name: John
  full_name: Parsch, John
  last_name: Parsch
citation:
  ama: Argyridou E, Huylmans AK, Königer A, Parsch J. X-linkage is not a general inhibitor
    of tissue-specific gene expression in Drosophila melanogaster. <i>Heredity</i>.
    2017;119(1):27-34. doi:<a href="https://doi.org/10.1038/hdy.2017.12">10.1038/hdy.2017.12</a>
  apa: Argyridou, E., Huylmans, A. K., Königer, A., &#38; Parsch, J. (2017). X-linkage
    is not a general inhibitor of tissue-specific gene expression in Drosophila melanogaster.
    <i>Heredity</i>. Nature Publishing Group. <a href="https://doi.org/10.1038/hdy.2017.12">https://doi.org/10.1038/hdy.2017.12</a>
  chicago: Argyridou, Eliza, Ann K Huylmans, Annabella Königer, and John Parsch. “X-Linkage
    Is Not a General Inhibitor of Tissue-Specific Gene Expression in Drosophila Melanogaster.”
    <i>Heredity</i>. Nature Publishing Group, 2017. <a href="https://doi.org/10.1038/hdy.2017.12">https://doi.org/10.1038/hdy.2017.12</a>.
  ieee: E. Argyridou, A. K. Huylmans, A. Königer, and J. Parsch, “X-linkage is not
    a general inhibitor of tissue-specific gene expression in Drosophila melanogaster,”
    <i>Heredity</i>, vol. 119, no. 1. Nature Publishing Group, pp. 27–34, 2017.
  ista: Argyridou E, Huylmans AK, Königer A, Parsch J. 2017. X-linkage is not a general
    inhibitor of tissue-specific gene expression in Drosophila melanogaster. Heredity.
    119(1), 27–34.
  mla: Argyridou, Eliza, et al. “X-Linkage Is Not a General Inhibitor of Tissue-Specific
    Gene Expression in Drosophila Melanogaster.” <i>Heredity</i>, vol. 119, no. 1,
    Nature Publishing Group, 2017, pp. 27–34, doi:<a href="https://doi.org/10.1038/hdy.2017.12">10.1038/hdy.2017.12</a>.
  short: E. Argyridou, A.K. Huylmans, A. Königer, J. Parsch, Heredity 119 (2017) 27–34.
date_created: 2018-12-11T11:49:43Z
date_published: 2017-07-01T00:00:00Z
date_updated: 2023-09-22T09:41:21Z
day: '01'
department:
- _id: BeVi
doi: 10.1038/hdy.2017.12
external_id:
  isi:
  - '000405397800004'
intvolume: '       119'
isi: 1
issue: '1'
language:
- iso: eng
month: '07'
oa_version: None
page: 27 - 34
publication: Heredity
publication_identifier:
  issn:
  - 0018067X
publication_status: published
publisher: Nature Publishing Group
publist_id: '6374'
quality_controlled: '1'
related_material:
  record:
  - id: '9861'
    relation: research_data
    status: public
scopus_import: '1'
status: public
title: X-linkage is not a general inhibitor of tissue-specific gene expression in
  Drosophila melanogaster
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 119
year: '2017'
...