[{"issue":"1","page":"27 - 34","language":[{"iso":"eng"}],"_id":"1019","month":"07","author":[{"first_name":"Eliza","last_name":"Argyridou","full_name":"Argyridou, Eliza"},{"full_name":"Huylmans, Ann K","orcid":"0000-0001-8871-4961","first_name":"Ann K","last_name":"Huylmans","id":"4C0A3874-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Königer, Annabella","first_name":"Annabella","last_name":"Königer"},{"full_name":"Parsch, John","first_name":"John","last_name":"Parsch"}],"citation":{"ieee":"E. Argyridou, A. K. Huylmans, A. Königer, and J. Parsch, “X-linkage is not a general inhibitor of tissue-specific gene expression in Drosophila melanogaster,” <i>Heredity</i>, vol. 119, no. 1. Nature Publishing Group, pp. 27–34, 2017.","chicago":"Argyridou, Eliza, Ann K Huylmans, Annabella Königer, and John Parsch. “X-Linkage Is Not a General Inhibitor of Tissue-Specific Gene Expression in Drosophila Melanogaster.” <i>Heredity</i>. Nature Publishing Group, 2017. <a href=\"https://doi.org/10.1038/hdy.2017.12\">https://doi.org/10.1038/hdy.2017.12</a>.","short":"E. Argyridou, A.K. Huylmans, A. Königer, J. Parsch, Heredity 119 (2017) 27–34.","mla":"Argyridou, Eliza, et al. “X-Linkage Is Not a General Inhibitor of Tissue-Specific Gene Expression in Drosophila Melanogaster.” <i>Heredity</i>, vol. 119, no. 1, Nature Publishing Group, 2017, pp. 27–34, doi:<a href=\"https://doi.org/10.1038/hdy.2017.12\">10.1038/hdy.2017.12</a>.","ama":"Argyridou E, Huylmans AK, Königer A, Parsch J. X-linkage is not a general inhibitor of tissue-specific gene expression in Drosophila melanogaster. <i>Heredity</i>. 2017;119(1):27-34. doi:<a href=\"https://doi.org/10.1038/hdy.2017.12\">10.1038/hdy.2017.12</a>","apa":"Argyridou, E., Huylmans, A. K., Königer, A., &#38; Parsch, J. (2017). X-linkage is not a general inhibitor of tissue-specific gene expression in Drosophila melanogaster. <i>Heredity</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/hdy.2017.12\">https://doi.org/10.1038/hdy.2017.12</a>","ista":"Argyridou E, Huylmans AK, Königer A, Parsch J. 2017. X-linkage is not a general inhibitor of tissue-specific gene expression in Drosophila melanogaster. Heredity. 119(1), 27–34."},"year":"2017","related_material":{"record":[{"relation":"research_data","id":"9861","status":"public"}]},"article_processing_charge":"No","isi":1,"external_id":{"isi":["000405397800004"]},"title":"X-linkage is not a general inhibitor of tissue-specific gene expression in Drosophila melanogaster","doi":"10.1038/hdy.2017.12","date_updated":"2023-09-22T09:41:21Z","publication_identifier":{"issn":["0018067X"]},"day":"01","status":"public","date_published":"2017-07-01T00:00:00Z","publist_id":"6374","publication":"Heredity","abstract":[{"lang":"eng","text":"As a consequence of its difference in copy number between males and females, the X chromosome is subject to unique evolutionary forces and gene regulatory mechanisms. Previous studies of Drosophila melanogaster have shown that the expression of X-linked, testis-specific reporter genes is suppressed in the male germline. However, it is not known whether this phenomenon is restricted to testis-expressed genes or if it is a more general property of genes with tissue-specific expression, which are also underrepresented on the X chromosome. To test this, we compared the expression of three tissue-specific reporter genes (ovary, accessory gland and Malpighian tubule) inserted at various autosomal and X-chromosomal locations. In contrast to testis-specific reporter genes, we found no reduction of X-linked expression in any of the other tissues. In accessory gland and Malpighian tubule, we detected higher expression of the X-linked reporter genes, which suggests that they are at least partially dosage compensated. We found no difference in the tissue-specificity of X-linked and autosomal reporter genes. These findings indicate that, in general, the X chromosome is not a detrimental environment for tissue-specific gene expression and that the suppression of X-linked expression is limited to the male germline."}],"intvolume":"       119","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","oa_version":"None","date_created":"2018-12-11T11:49:43Z","scopus_import":"1","volume":119,"type":"journal_article","quality_controlled":"1","department":[{"_id":"BeVi"}],"publisher":"Nature Publishing Group","publication_status":"published"}]