---
_id: '621'
abstract:
- lang: eng
  text: The mammalian cerebral cortex is responsible for higher cognitive functions
    such as perception, consciousness, and acquiring and processing information. The
    neocortex is organized into six distinct laminae, each composed of a rich diversity
    of cell types which assemble into highly complex cortical circuits. Radial glia
    progenitors (RGPs) are responsible for producing all neocortical neurons and certain
    glia lineages. Here, we discuss recent discoveries emerging from clonal lineage
    analysis at the single RGP cell level that provide us with an inaugural quantitative
    framework of RGP lineage progression. We further discuss the importance of the
    relative contribution of intrinsic gene functions and non-cell-autonomous or community
    effects in regulating RGP proliferation behavior and lineage progression.
article_processing_charge: Yes (in subscription journal)
author:
- first_name: Robert J
  full_name: Beattie, Robert J
  id: 2E26DF60-F248-11E8-B48F-1D18A9856A87
  last_name: Beattie
  orcid: 0000-0002-8483-8753
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
citation:
  ama: Beattie RJ, Hippenmeyer S. Mechanisms of radial glia progenitor cell lineage
    progression. <i>FEBS letters</i>. 2017;591(24):3993-4008. doi:<a href="https://doi.org/10.1002/1873-3468.12906">10.1002/1873-3468.12906</a>
  apa: Beattie, R. J., &#38; Hippenmeyer, S. (2017). Mechanisms of radial glia progenitor
    cell lineage progression. <i>FEBS Letters</i>. Wiley-Blackwell. <a href="https://doi.org/10.1002/1873-3468.12906">https://doi.org/10.1002/1873-3468.12906</a>
  chicago: Beattie, Robert J, and Simon Hippenmeyer. “Mechanisms of Radial Glia Progenitor
    Cell Lineage Progression.” <i>FEBS Letters</i>. Wiley-Blackwell, 2017. <a href="https://doi.org/10.1002/1873-3468.12906">https://doi.org/10.1002/1873-3468.12906</a>.
  ieee: R. J. Beattie and S. Hippenmeyer, “Mechanisms of radial glia progenitor cell
    lineage progression,” <i>FEBS letters</i>, vol. 591, no. 24. Wiley-Blackwell,
    pp. 3993–4008, 2017.
  ista: Beattie RJ, Hippenmeyer S. 2017. Mechanisms of radial glia progenitor cell
    lineage progression. FEBS letters. 591(24), 3993–4008.
  mla: Beattie, Robert J., and Simon Hippenmeyer. “Mechanisms of Radial Glia Progenitor
    Cell Lineage Progression.” <i>FEBS Letters</i>, vol. 591, no. 24, Wiley-Blackwell,
    2017, pp. 3993–4008, doi:<a href="https://doi.org/10.1002/1873-3468.12906">10.1002/1873-3468.12906</a>.
  short: R.J. Beattie, S. Hippenmeyer, FEBS Letters 591 (2017) 3993–4008.
date_created: 2018-12-11T11:47:32Z
date_published: 2017-12-01T00:00:00Z
date_updated: 2024-02-14T12:02:08Z
day: '01'
ddc:
- '571'
- '610'
department:
- _id: SiHi
doi: 10.1002/1873-3468.12906
ec_funded: 1
external_id:
  pmid:
  - '29121403'
file:
- access_level: open_access
  checksum: a46dadc84e0c28d389dd3e9e954464db
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:16:24Z
  date_updated: 2020-07-14T12:47:24Z
  file_id: '5211'
  file_name: IST-2018-928-v1+1_Beattie_et_al-2017-FEBS_Letters.pdf
  file_size: 644149
  relation: main_file
file_date_updated: 2020-07-14T12:47:24Z
has_accepted_license: '1'
intvolume: '       591'
issue: '24'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc/4.0/
month: '12'
oa: 1
oa_version: Published Version
page: 3993  - 4008
pmid: 1
project:
- _id: 25D7962E-B435-11E9-9278-68D0E5697425
  grant_number: RGP0053/2014
  name: Quantitative Structure-Function Analysis of Cerebral Cortex Assembly at Clonal
    Level
- _id: 25D61E48-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '618444'
  name: Molecular Mechanisms of Cerebral Cortex Development
publication: FEBS letters
publication_identifier:
  issn:
  - '00145793'
publication_status: published
publisher: Wiley-Blackwell
publist_id: '7183'
pubrep_id: '928'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mechanisms of radial glia progenitor cell lineage progression
tmp:
  image: /images/cc_by_nc.png
  legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
  short: CC BY-NC (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 591
year: '2017'
...
---
_id: '2242'
abstract:
- lang: eng
  text: MicroRNAs (miRNAs) are small RNAs that play important regulatory roles in
    many cellular pathways. MiRNAs associate with members of the Argonaute protein
    family and bind to partially complementary sequences on mRNAs and induce translational
    repression or mRNA decay. Using deep sequencing and Northern blotting, we characterized
    miRNA expression in wild type and miR-155-deficient dendritic cells (DCs) and
    macrophages. Analysis of different stimuli (LPS, LDL, eLDL, oxLDL) reveals a direct
    influence of miR-155 on the expression levels of other miRNAs. For example, miR-455
    is negatively regulated in miR-155-deficient cells possibly due to inhibition
    of the transcription factor C/EBPbeta by miR-155. Based on our comprehensive data
    sets, we propose a model of hierarchical miRNA expression dominated by miR-155
    in DCs and macrophages.
author:
- first_name: Anne
  full_name: Dueck, Anne
  last_name: Dueck
- first_name: Alexander
  full_name: Eichner, Alexander
  id: 4DFA52AE-F248-11E8-B48F-1D18A9856A87
  last_name: Eichner
- first_name: Michael K
  full_name: Sixt, Michael K
  id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
  last_name: Sixt
  orcid: 0000-0002-6620-9179
- first_name: Gunter
  full_name: Meister, Gunter
  last_name: Meister
citation:
  ama: Dueck A, Eichner A, Sixt MK, Meister G. A miR-155-dependent microRNA hierarchy
    in dendritic cell maturation and macrophage activation. <i>FEBS Letters</i>. 2014;588(4):632-640.
    doi:<a href="https://doi.org/10.1016/j.febslet.2014.01.009">10.1016/j.febslet.2014.01.009</a>
  apa: Dueck, A., Eichner, A., Sixt, M. K., &#38; Meister, G. (2014). A miR-155-dependent
    microRNA hierarchy in dendritic cell maturation and macrophage activation. <i>FEBS
    Letters</i>. Elsevier. <a href="https://doi.org/10.1016/j.febslet.2014.01.009">https://doi.org/10.1016/j.febslet.2014.01.009</a>
  chicago: Dueck, Anne, Alexander Eichner, Michael K Sixt, and Gunter Meister. “A
    MiR-155-Dependent MicroRNA Hierarchy in Dendritic Cell Maturation and Macrophage
    Activation.” <i>FEBS Letters</i>. Elsevier, 2014. <a href="https://doi.org/10.1016/j.febslet.2014.01.009">https://doi.org/10.1016/j.febslet.2014.01.009</a>.
  ieee: A. Dueck, A. Eichner, M. K. Sixt, and G. Meister, “A miR-155-dependent microRNA
    hierarchy in dendritic cell maturation and macrophage activation,” <i>FEBS Letters</i>,
    vol. 588, no. 4. Elsevier, pp. 632–640, 2014.
  ista: Dueck A, Eichner A, Sixt MK, Meister G. 2014. A miR-155-dependent microRNA
    hierarchy in dendritic cell maturation and macrophage activation. FEBS Letters.
    588(4), 632–640.
  mla: Dueck, Anne, et al. “A MiR-155-Dependent MicroRNA Hierarchy in Dendritic Cell
    Maturation and Macrophage Activation.” <i>FEBS Letters</i>, vol. 588, no. 4, Elsevier,
    2014, pp. 632–40, doi:<a href="https://doi.org/10.1016/j.febslet.2014.01.009">10.1016/j.febslet.2014.01.009</a>.
  short: A. Dueck, A. Eichner, M.K. Sixt, G. Meister, FEBS Letters 588 (2014) 632–640.
date_created: 2018-12-11T11:56:31Z
date_published: 2014-02-14T00:00:00Z
date_updated: 2021-01-12T06:56:14Z
day: '14'
department:
- _id: MiSi
doi: 10.1016/j.febslet.2014.01.009
intvolume: '       588'
issue: '4'
language:
- iso: eng
month: '02'
oa_version: None
page: 632 - 640
publication: FEBS Letters
publication_identifier:
  issn:
  - '00145793'
publication_status: published
publisher: Elsevier
publist_id: '4714'
quality_controlled: '1'
scopus_import: 1
status: public
title: A miR-155-dependent microRNA hierarchy in dendritic cell maturation and macrophage
  activation
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 588
year: '2014'
...