---
_id: '2485'
abstract:
- lang: eng
  text: Endothelins (ETs) are very potent vasoconstrictive peptides and have diverse
    functions in both vascular and nonvascular tissues. This investigation concerns
    the tissue distribution and cellular localization of rat mRNAs encoding two different
    subtypes of ET receptors (ET(A) and ET(B)). We isolated 46 cDNA clones from a
    rat lung cDNA library by hybridization with the bovine ET(A) cDNA. The characterization
    of these cDNA clones indicated that they represent either the ET(A) or ET(B) cDNA.
    In situ and blot hybridization analyses revealed that the rat ET(A) mRNA is predominantly
    expressed in vascular smooth muscle cells of a variety of tissues, bronchial smooth
    muscle cells, myocardium, and the pituitary gland. There is no significant expression
    of ET(B) mRNA in vascular smooth muscle cells, and ET(A), thus, plays a primary
    role in ET-induced vascular contraction. ET(B) mRNA is more widely distributed
    in various cell types of many tissues. Its prominent expression is seen in glial
    cells throughout the brain regions, epithelial cells of the choroid plexus, ependymal
    cells lining the ventricle, myocardium, endothelial cells of glomeruli, and epithelial
    cells of the thin segments of Henle's loops. Our investigation demonstrates that
    the mRNAs for the two subtypes of rat ET receptors show specialized expression
    patterns of cell types in both brain and peripheral tissues.
article_processing_charge: No
article_type: original
author:
- first_name: Seiji
  full_name: Hori, Seiji
  last_name: Hori
- first_name: Yasato
  full_name: Komatsu, Yasato
  last_name: Komatsu
- first_name: Ryuichi
  full_name: Shigemoto, Ryuichi
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
- first_name: Noboru
  full_name: Mizuno, Noboru
  last_name: Mizuno
- first_name: Shigetada
  full_name: Nakanishi, Shigetada
  last_name: Nakanishi
citation:
  ama: Hori S, Komatsu Y, Shigemoto R, Mizuno N, Nakanishi S. Distinct tissue distribution
    and cellular localization of two messenger ribonucleic acids encoding different
    subtypes of rat endothelin receptors. <i>Endocrinology</i>. 1992;130(4):1885-1895.
    doi:<a href="https://doi.org/10.1210/endo.130.4.1312429">10.1210/endo.130.4.1312429</a>
  apa: Hori, S., Komatsu, Y., Shigemoto, R., Mizuno, N., &#38; Nakanishi, S. (1992).
    Distinct tissue distribution and cellular localization of two messenger ribonucleic
    acids encoding different subtypes of rat endothelin receptors. <i>Endocrinology</i>.
    The Endocrine Society. <a href="https://doi.org/10.1210/endo.130.4.1312429">https://doi.org/10.1210/endo.130.4.1312429</a>
  chicago: Hori, Seiji, Yasato Komatsu, Ryuichi Shigemoto, Noboru Mizuno, and Shigetada
    Nakanishi. “Distinct Tissue Distribution and Cellular Localization of Two Messenger
    Ribonucleic Acids Encoding Different Subtypes of Rat Endothelin Receptors.” <i>Endocrinology</i>.
    The Endocrine Society, 1992. <a href="https://doi.org/10.1210/endo.130.4.1312429">https://doi.org/10.1210/endo.130.4.1312429</a>.
  ieee: S. Hori, Y. Komatsu, R. Shigemoto, N. Mizuno, and S. Nakanishi, “Distinct
    tissue distribution and cellular localization of two messenger ribonucleic acids
    encoding different subtypes of rat endothelin receptors,” <i>Endocrinology</i>,
    vol. 130, no. 4. The Endocrine Society, pp. 1885–1895, 1992.
  ista: Hori S, Komatsu Y, Shigemoto R, Mizuno N, Nakanishi S. 1992. Distinct tissue
    distribution and cellular localization of two messenger ribonucleic acids encoding
    different subtypes of rat endothelin receptors. Endocrinology. 130(4), 1885–1895.
  mla: Hori, Seiji, et al. “Distinct Tissue Distribution and Cellular Localization
    of Two Messenger Ribonucleic Acids Encoding Different Subtypes of Rat Endothelin
    Receptors.” <i>Endocrinology</i>, vol. 130, no. 4, The Endocrine Society, 1992,
    pp. 1885–95, doi:<a href="https://doi.org/10.1210/endo.130.4.1312429">10.1210/endo.130.4.1312429</a>.
  short: S. Hori, Y. Komatsu, R. Shigemoto, N. Mizuno, S. Nakanishi, Endocrinology
    130 (1992) 1885–1895.
date_created: 2018-12-11T11:57:56Z
date_published: 1992-04-01T00:00:00Z
date_updated: 2022-03-21T09:54:59Z
day: '01'
doi: 10.1210/endo.130.4.1312429
extern: '1'
external_id:
  pmid:
  - '1312429'
intvolume: '       130'
issue: '4'
language:
- iso: eng
main_file_link:
- url: https://academic.oup.com/endo/article-abstract/130/4/1885/2535978
month: '04'
oa_version: None
page: 1885 - 1895
pmid: 1
publication: Endocrinology
publication_identifier:
  issn:
  - 0013-7227
publication_status: published
publisher: The Endocrine Society
publist_id: '4416'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Distinct tissue distribution and cellular localization of two messenger ribonucleic
  acids encoding different subtypes of rat endothelin receptors
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 130
year: '1992'
...