---
_id: '5787'
abstract:
- lang: eng
  text: "Branching  morphogenesis  remains  a  subject  of  abiding  interest.  Although
    \ much  is  \r\nknown about the gene regulatory programs and signaling pathways
    that operate at \r\nthe cellular scale, it has remained unclear how the macroscopic
    features of branched \r\norgans,  including  their  size,  network  topology  and
    \ spatial  patterning,  are  encoded.  \r\nLately, it has been proposed that,
    these features can be explained quantitatively in \r\nseveral organs within a
    single unifying framework. Based on large-\r\nscale organ recon\r\n-\r\nstructions
    \ and  cell  lineage  tracing,  it  has  been  argued  that  morphogenesis  follows
    \ \r\nfrom the collective dynamics of sublineage- \r\nrestricted self- \r\nrenewing
    progenitor cells, \r\nlocalized at ductal tips, that act cooperatively to drive
    a serial process of ductal elon\r\n-\r\ngation and stochastic tip bifurcation.
    By correlating differentiation or cell cycle exit \r\nwith proximity to maturing
    ducts, this dynamic results in the specification of a com-\r\nplex  network  of
    \ defined  density  and  statistical  organization.  These  results  suggest  \r\nthat,
    for several mammalian tissues, branched epithelial structures develop as a self-
    \r\norganized  process,  reliant  upon  a  strikingly  simple,  but  generic,
    \ set  of  local  rules,  \r\nwithout  recourse  to  a  rigid  and  deterministic
    \ sequence  of  genetically  programmed  \r\nevents. Here, we review the basis
    of these findings and discuss their implications."
article_processing_charge: No
author:
- first_name: Edouard B
  full_name: Hannezo, Edouard B
  id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
  last_name: Hannezo
  orcid: 0000-0001-6005-1561
- first_name: Benjamin D.
  full_name: Simons, Benjamin D.
  last_name: Simons
citation:
  ama: Hannezo EB, Simons BD. Statistical theory of branching morphogenesis. <i>Development
    Growth and Differentiation</i>. 2018;60(9):512-521. doi:<a href="https://doi.org/10.1111/dgd.12570">10.1111/dgd.12570</a>
  apa: Hannezo, E. B., &#38; Simons, B. D. (2018). Statistical theory of branching
    morphogenesis. <i>Development Growth and Differentiation</i>. Wiley. <a href="https://doi.org/10.1111/dgd.12570">https://doi.org/10.1111/dgd.12570</a>
  chicago: Hannezo, Edouard B, and Benjamin D. Simons. “Statistical Theory of Branching
    Morphogenesis.” <i>Development Growth and Differentiation</i>. Wiley, 2018. <a
    href="https://doi.org/10.1111/dgd.12570">https://doi.org/10.1111/dgd.12570</a>.
  ieee: E. B. Hannezo and B. D. Simons, “Statistical theory of branching morphogenesis,”
    <i>Development Growth and Differentiation</i>, vol. 60, no. 9. Wiley, pp. 512–521,
    2018.
  ista: Hannezo EB, Simons BD. 2018. Statistical theory of branching morphogenesis.
    Development Growth and Differentiation. 60(9), 512–521.
  mla: Hannezo, Edouard B., and Benjamin D. Simons. “Statistical Theory of Branching
    Morphogenesis.” <i>Development Growth and Differentiation</i>, vol. 60, no. 9,
    Wiley, 2018, pp. 512–21, doi:<a href="https://doi.org/10.1111/dgd.12570">10.1111/dgd.12570</a>.
  short: E.B. Hannezo, B.D. Simons, Development Growth and Differentiation 60 (2018)
    512–521.
date_created: 2018-12-30T22:59:14Z
date_published: 2018-12-09T00:00:00Z
date_updated: 2023-09-19T09:32:49Z
day: '09'
ddc:
- '570'
department:
- _id: EdHa
doi: 10.1111/dgd.12570
external_id:
  isi:
  - '000453555100002'
file:
- access_level: open_access
  checksum: a6d30b0785db902c734a84fecb2eadd9
  content_type: application/pdf
  creator: dernst
  date_created: 2019-02-06T10:40:46Z
  date_updated: 2020-07-14T12:47:11Z
  file_id: '5933'
  file_name: 2018_DevGrowh_Hannezo.pdf
  file_size: 1313606
  relation: main_file
file_date_updated: 2020-07-14T12:47:11Z
has_accepted_license: '1'
intvolume: '        60'
isi: 1
issue: '9'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: 512-521
publication: Development Growth and Differentiation
publication_identifier:
  issn:
  - '00121592'
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Statistical theory of branching morphogenesis
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 60
year: '2018'
...