---
_id: '2532'
abstract:
- lang: eng
  text: In the present study, we have investigated the expression of both the erythrocyte-type
    (GLUT1) and the brain-type (GLUT3) glucose transporter isoforms in primary human
    brain tumors. In situ hybridization made it possible to localize and semiquantify
    both GLUT1 and GLUT3 mRNAs of individual cells in all 18 samples examined. More
    signals for GLUT3 mRNA than for GLUT1 mRNA were found over astrocytoma cells,
    while the reverse was the case in all 6 meningiomas. In astrocytomas, for both
    mRNAs, the density of silver grains over tumor cells was well correlated with
    the malignancy of the cells. This correlation was, as was also confirmed by Northern
    blot analysis, more marked with GLUT3 mRNA than with GLUT1 mRNA. In 2 of 5 anaplastic
    astrocytomas and in all 3 glioblastomas, numerous tumor cells with large amounts
    of both mRNAs tended to surround the perivascular regions. 'Tumor vessels' with
    endothelial proliferation, an almost pathognomonic feature of glioblastomas, expressed
    much GLUT3 mRNA but no significant GLUT1 mRNA, while a single- or a few-layered
    capillary endothelium expressed much GLUT1 mRNA. The distribution of both mRNAs
    was in good accordance with that of both proteins. Our results suggest that the
    expression of both glucose transporter isoforms may contribute to the maintenance
    of human brain tumors and that the expression of the GLUT3 isoform may be closely
    related to the malignant change of astrocytomas and particularly related to the
    aberrant neovascularization which accompanies glioblastomas.
acknowledgement: 'We wish to acknowledge generous donations of human samples by the
  following neurosurgeons: Drs. Taro Fukumitsu. Akinori Kondo, Toyoshiro Yamamoto,
  Juji Takeuchi, Junya Hanakita, Syunichi Yoneda, and Michio Nishikawa. We are very
  grateful to Dr. G. I. Bell (The University of Chicago) for providing the cDNA clones
  of GLUTI and GLUT3. We thank Drs. Yoshifumi Yokota, Yuichiro Yamada. and Manabu
  Fukumoto for their helpful advice. We also thank Yoshinobu Toda and Hiroko Sato
  for their expert technical assistance. Supported in part by Grants in Aids for Basic
  Research on Radiation Therapy (03151034) and Special Project Research on Cancer
  Bio-Science from the Ministry of Education, Science, and Culture of Japan, by Takeda
  Medical Foundation, and by Monbusho International Scientific Research: Joint Research.'
article_processing_charge: No
article_type: original
author:
- first_name: Tatsuya
  full_name: Nishioka, Tatsuya
  last_name: Nishioka
- first_name: Yoshifumi
  full_name: Oda, Yoshifumi
  last_name: Oda
- first_name: Yutaka
  full_name: Seino, Yutaka
  last_name: Seino
- first_name: Taizo
  full_name: Yamamoto, Taizo
  last_name: Yamamoto
- first_name: Nobuya
  full_name: Inagaki, Nobuya
  last_name: Inagaki
- first_name: Hideki
  full_name: Yano, Hideki
  last_name: Yano
- first_name: Hiroo
  full_name: Imura, Hiroo
  last_name: Imura
- first_name: Ryuichi
  full_name: Shigemoto, Ryuichi
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
- first_name: Haruhiko
  full_name: Kikuchi, Haruhiko
  last_name: Kikuchi
citation:
  ama: Nishioka T, Oda Y, Seino Y, et al. Distribution of the glucose transporters
    in human brain tumors. <i>Cancer Research</i>. 1992;52(14):3972-3979.
  apa: Nishioka, T., Oda, Y., Seino, Y., Yamamoto, T., Inagaki, N., Yano, H., … Kikuchi,
    H. (1992). Distribution of the glucose transporters in human brain tumors. <i>Cancer
    Research</i>. American Association for Cancer Research.
  chicago: Nishioka, Tatsuya, Yoshifumi Oda, Yutaka Seino, Taizo Yamamoto, Nobuya
    Inagaki, Hideki Yano, Hiroo Imura, Ryuichi Shigemoto, and Haruhiko Kikuchi. “Distribution
    of the Glucose Transporters in Human Brain Tumors.” <i>Cancer Research</i>. American
    Association for Cancer Research, 1992.
  ieee: T. Nishioka <i>et al.</i>, “Distribution of the glucose transporters in human
    brain tumors,” <i>Cancer Research</i>, vol. 52, no. 14. American Association for
    Cancer Research, pp. 3972–3979, 1992.
  ista: Nishioka T, Oda Y, Seino Y, Yamamoto T, Inagaki N, Yano H, Imura H, Shigemoto
    R, Kikuchi H. 1992. Distribution of the glucose transporters in human brain tumors.
    Cancer Research. 52(14), 3972–3979.
  mla: Nishioka, Tatsuya, et al. “Distribution of the Glucose Transporters in Human
    Brain Tumors.” <i>Cancer Research</i>, vol. 52, no. 14, American Association for
    Cancer Research, 1992, pp. 3972–79.
  short: T. Nishioka, Y. Oda, Y. Seino, T. Yamamoto, N. Inagaki, H. Yano, H. Imura,
    R. Shigemoto, H. Kikuchi, Cancer Research 52 (1992) 3972–3979.
date_created: 2018-12-11T11:58:13Z
date_published: 1992-01-01T00:00:00Z
date_updated: 2022-03-17T15:38:42Z
day: '01'
extern: '1'
external_id:
  pmid:
  - '1617673'
intvolume: '        52'
issue: '14'
language:
- iso: eng
main_file_link:
- url: https://aacrjournals.org/cancerres/article/52/14/3972/497930/Distribution-of-the-Glucose-Transporters-in-Human
month: '01'
oa_version: None
page: 3972 - 3979
pmid: 1
publication: Cancer Research
publication_identifier:
  issn:
  - 0008-5472
publication_status: published
publisher: American Association for Cancer Research
publist_id: '4367'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Distribution of the glucose transporters in human brain tumors
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 52
year: '1992'
...