---
_id: '6896'
abstract:
- lang: eng
  text: "Until recently, a great amount of brain studies have been conducted in human
    post mortem tissues, cell lines and model organisms. These researches provided
    useful insights regarding cell-cell interactions occurring in the brain. However,
    such approaches suffer from technical limitations and inaccurate modeling of the
    tissue 3D cytoarchitecture. Importantly, they might lack a human genetic background
    essential for disease modeling. With the development of protocols to generate
    human cerebral organoids, we are now closer to reproducing the early stages of
    human brain development in vitro. As a result, more relevant cell-cell interaction
    studies can be conducted.\r\n\r\nIn this review, we discuss the advantages of
    3D cultures over 2D in modulating brain cell-cell interactions during physiological
    and pathological development, as well as the progress made in developing organoids
    in which neurons, macroglia, microglia and vascularization are present. Finally,
    we debate the limitations of those models and possible future directions."
article_number: '146458'
article_processing_charge: No
article_type: original
author:
- first_name: Bárbara
  full_name: Oliveira, Bárbara
  id: 3B03AA1A-F248-11E8-B48F-1D18A9856A87
  last_name: Oliveira
- first_name: Aysan Çerağ
  full_name: Yahya, Aysan Çerağ
  id: 365A65F8-F248-11E8-B48F-1D18A9856A87
  last_name: Yahya
- first_name: Gaia
  full_name: Novarino, Gaia
  id: 3E57A680-F248-11E8-B48F-1D18A9856A87
  last_name: Novarino
  orcid: 0000-0002-7673-7178
citation:
  ama: Oliveira B, Yahya AÇ, Novarino G. Modeling cell-cell interactions in the brain
    using cerebral organoids. <i>Brain Research</i>. 2019;1724. doi:<a href="https://doi.org/10.1016/j.brainres.2019.146458">10.1016/j.brainres.2019.146458</a>
  apa: Oliveira, B., Yahya, A. Ç., &#38; Novarino, G. (2019). Modeling cell-cell interactions
    in the brain using cerebral organoids. <i>Brain Research</i>. Elsevier. <a href="https://doi.org/10.1016/j.brainres.2019.146458">https://doi.org/10.1016/j.brainres.2019.146458</a>
  chicago: Oliveira, Bárbara, Aysan Çerağ Yahya, and Gaia Novarino. “Modeling Cell-Cell
    Interactions in the Brain Using Cerebral Organoids.” <i>Brain Research</i>. Elsevier,
    2019. <a href="https://doi.org/10.1016/j.brainres.2019.146458">https://doi.org/10.1016/j.brainres.2019.146458</a>.
  ieee: B. Oliveira, A. Ç. Yahya, and G. Novarino, “Modeling cell-cell interactions
    in the brain using cerebral organoids,” <i>Brain Research</i>, vol. 1724. Elsevier,
    2019.
  ista: Oliveira B, Yahya AÇ, Novarino G. 2019. Modeling cell-cell interactions in
    the brain using cerebral organoids. Brain Research. 1724, 146458.
  mla: Oliveira, Bárbara, et al. “Modeling Cell-Cell Interactions in the Brain Using
    Cerebral Organoids.” <i>Brain Research</i>, vol. 1724, 146458, Elsevier, 2019,
    doi:<a href="https://doi.org/10.1016/j.brainres.2019.146458">10.1016/j.brainres.2019.146458</a>.
  short: B. Oliveira, A.Ç. Yahya, G. Novarino, Brain Research 1724 (2019).
date_created: 2019-09-22T22:00:35Z
date_published: 2019-12-01T00:00:00Z
date_updated: 2023-08-30T06:19:49Z
day: '01'
department:
- _id: GaNo
doi: 10.1016/j.brainres.2019.146458
external_id:
  isi:
  - '000491646600033'
  pmid:
  - '31521639'
intvolume: '      1724'
isi: 1
language:
- iso: eng
month: '12'
oa_version: None
pmid: 1
publication: Brain Research
publication_identifier:
  eissn:
  - '18726240'
  issn:
  - '00068993'
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Modeling cell-cell interactions in the brain using cerebral organoids
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 1724
year: '2019'
...