---
_id: '2231'
abstract:
- lang: eng
  text: Based on the measurements of noise in gene expression performed during the
    past decade, it has become customary to think of gene regulation in terms of a
    two-state model, where the promoter of a gene can stochastically switch between
    an ON and an OFF state. As experiments are becoming increasingly precise and the
    deviations from the two-state model start to be observable, we ask about the experimental
    signatures of complex multistate promoters, as well as the functional consequences
    of this additional complexity. In detail, we i), extend the calculations for noise
    in gene expression to promoters described by state transition diagrams with multiple
    states, ii), systematically compute the experimentally accessible noise characteristics
    for these complex promoters, and iii), use information theory to evaluate the
    channel capacities of complex promoter architectures and compare them with the
    baseline provided by the two-state model. We find that adding internal states
    to the promoter generically decreases channel capacity, except in certain cases,
    three of which (cooperativity, dual-role regulation, promoter cycling) we analyze
    in detail.
author:
- first_name: Georg
  full_name: Rieckh, Georg
  id: 34DA8BD6-F248-11E8-B48F-1D18A9856A87
  last_name: Rieckh
- first_name: Gasper
  full_name: Tkacik, Gasper
  id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
  last_name: Tkacik
  orcid: 0000-0002-6699-1455
citation:
  ama: Rieckh G, Tkačik G. Noise and information transmission in promoters with multiple
    internal states. <i>Biophysical Journal</i>. 2014;106(5):1194-1204. doi:<a href="https://doi.org/10.1016/j.bpj.2014.01.014">10.1016/j.bpj.2014.01.014</a>
  apa: Rieckh, G., &#38; Tkačik, G. (2014). Noise and information transmission in
    promoters with multiple internal states. <i>Biophysical Journal</i>. Biophysical
    Society. <a href="https://doi.org/10.1016/j.bpj.2014.01.014">https://doi.org/10.1016/j.bpj.2014.01.014</a>
  chicago: Rieckh, Georg, and Gašper Tkačik. “Noise and Information Transmission in
    Promoters with Multiple Internal States.” <i>Biophysical Journal</i>. Biophysical
    Society, 2014. <a href="https://doi.org/10.1016/j.bpj.2014.01.014">https://doi.org/10.1016/j.bpj.2014.01.014</a>.
  ieee: G. Rieckh and G. Tkačik, “Noise and information transmission in promoters
    with multiple internal states,” <i>Biophysical Journal</i>, vol. 106, no. 5. Biophysical
    Society, pp. 1194–1204, 2014.
  ista: Rieckh G, Tkačik G. 2014. Noise and information transmission in promoters
    with multiple internal states. Biophysical Journal. 106(5), 1194–1204.
  mla: Rieckh, Georg, and Gašper Tkačik. “Noise and Information Transmission in Promoters
    with Multiple Internal States.” <i>Biophysical Journal</i>, vol. 106, no. 5, Biophysical
    Society, 2014, pp. 1194–204, doi:<a href="https://doi.org/10.1016/j.bpj.2014.01.014">10.1016/j.bpj.2014.01.014</a>.
  short: G. Rieckh, G. Tkačik, Biophysical Journal 106 (2014) 1194–1204.
date_created: 2018-12-11T11:56:28Z
date_published: 2014-03-04T00:00:00Z
date_updated: 2021-01-12T06:56:10Z
day: '04'
department:
- _id: GaTk
doi: 10.1016/j.bpj.2014.01.014
external_id:
  pmid:
  - '24606943'
intvolume: '       106'
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026790/
month: '03'
oa: 1
oa_version: Submitted Version
page: 1194 - 1204
pmid: 1
publication: Biophysical Journal
publication_identifier:
  issn:
  - '00063495'
publication_status: published
publisher: Biophysical Society
publist_id: '4730'
quality_controlled: '1'
scopus_import: 1
status: public
title: Noise and information transmission in promoters with multiple internal states
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 106
year: '2014'
...