---
_id: '1945'
abstract:
- lang: eng
  text: The effects of ultra-low (10(-18)-10(-14) M) doses (ULD) of biologically active
    substances have been reviewed in terms of common regularities of ULD effects and
    peculiarities of action of various groups of compounds. The most common and at
    the same time paradoxical regularities of ULD action are bi- or polymodal patterns
    of dose dependence, absence or presence of an inverse effect at higher doses,
    and instability of ULD effect. Possible mechanisms of ULD action including the
    mechanism based on the adaptation theory are discussed.
article_processing_charge: No
article_type: original
author:
- first_name: Leonid A
  full_name: Sazanov, Leonid A
  id: 338D39FE-F248-11E8-B48F-1D18A9856A87
  last_name: Sazanov
  orcid: 0000-0002-0977-7989
- first_name: Sergei
  full_name: Zaǐtsev, Sergei
  last_name: Zaǐtsev
citation:
  ama: 'Sazanov LA, Zaǐtsev S. Effect of superlow doses (10(-18)-10-(-14) M) of biologically
    active substances: general rules, features, and possible mechanisms. <i>Biochemistry
    (Moscow)</i>. 1992;57(10):1443-1460.'
  apa: 'Sazanov, L. A., &#38; Zaǐtsev, S. (1992). Effect of superlow doses (10(-18)-10-(-14)
    M) of biologically active substances: general rules, features, and possible mechanisms.
    <i>Biochemistry (Moscow)</i>. Izdatel’stvo Nauka.'
  chicago: 'Sazanov, Leonid A, and Sergei Zaǐtsev. “Effect of Superlow Doses (10(-18)-10-(-14)
    M) of Biologically Active Substances: General Rules, Features, and Possible Mechanisms.”
    <i>Biochemistry (Moscow)</i>. Izdatel’stvo Nauka, 1992.'
  ieee: 'L. A. Sazanov and S. Zaǐtsev, “Effect of superlow doses (10(-18)-10-(-14)
    M) of biologically active substances: general rules, features, and possible mechanisms,”
    <i>Biochemistry (Moscow)</i>, vol. 57, no. 10. Izdatel’stvo Nauka, pp. 1443–1460,
    1992.'
  ista: 'Sazanov LA, Zaǐtsev S. 1992. Effect of superlow doses (10(-18)-10-(-14) M)
    of biologically active substances: general rules, features, and possible mechanisms.
    Biochemistry (Moscow). 57(10), 1443–1460.'
  mla: 'Sazanov, Leonid A., and Sergei Zaǐtsev. “Effect of Superlow Doses (10(-18)-10-(-14)
    M) of Biologically Active Substances: General Rules, Features, and Possible Mechanisms.”
    <i>Biochemistry (Moscow)</i>, vol. 57, no. 10, Izdatel’stvo Nauka, 1992, pp. 1443–60.'
  short: L.A. Sazanov, S. Zaǐtsev, Biochemistry (Moscow) 57 (1992) 1443–1460.
date_created: 2018-12-11T11:54:51Z
date_published: 1992-10-10T00:00:00Z
date_updated: 2022-03-21T10:47:19Z
day: '10'
extern: '1'
external_id:
  pmid:
  - '1457592 '
intvolume: '        57'
issue: '10'
language:
- iso: eng
main_file_link:
- url: https://europepmc.org/article/med/1457592
month: '10'
oa_version: None
page: 1443 - 1460
pmid: 1
publication: Biochemistry (Moscow)
publication_identifier:
  issn:
  - 0006-2979
publication_status: published
publisher: Izdatel'stvo Nauka
publist_id: '5138'
quality_controlled: '1'
status: public
title: 'Effect of superlow doses (10(-18)-10-(-14) M) of biologically active substances:
  general rules, features, and possible mechanisms'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 57
year: '1992'
...