---
_id: '14411'
abstract:
- lang: eng
  text: "Partially specified Boolean networks (PSBNs) represent a promising framework
    for the qualitative modelling of biological systems in which the logic of interactions
    is not completely known. Phenotype control aims to stabilise the network in states
    exhibiting specific traits.\r\nIn this paper, we define the phenotype control
    problem in the context of asynchronous PSBNs and propose a novel semi-symbolic
    algorithm for solving this problem with permanent variable perturbations."
acknowledgement: This work was supported by the Czech Foundation grant No. GA22-10845S,
  Grant Agency of Masaryk University grant No. MUNI/G/1771/2020, and the European
  Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie
  Grant Agreement No. 101034413.
alternative_title:
- LNBI
article_processing_charge: No
author:
- first_name: Nikola
  full_name: Beneš, Nikola
  last_name: Beneš
- first_name: Luboš
  full_name: Brim, Luboš
  last_name: Brim
- first_name: Samuel
  full_name: Pastva, Samuel
  id: 07c5ea74-f61c-11ec-a664-aa7c5d957b2b
  last_name: Pastva
  orcid: 0000-0003-1993-0331
- first_name: David
  full_name: Šafránek, David
  last_name: Šafránek
- first_name: Eva
  full_name: Šmijáková, Eva
  last_name: Šmijáková
citation:
  ama: 'Beneš N, Brim L, Pastva S, Šafránek D, Šmijáková E. Phenotype control of partially
    specified boolean networks. In: <i>21st International Conference on Computational
    Methods in Systems Biology</i>. Vol 14137. Springer Nature; 2023:18-35. doi:<a
    href="https://doi.org/10.1007/978-3-031-42697-1_2">10.1007/978-3-031-42697-1_2</a>'
  apa: 'Beneš, N., Brim, L., Pastva, S., Šafránek, D., &#38; Šmijáková, E. (2023).
    Phenotype control of partially specified boolean networks. In <i>21st International
    Conference on Computational Methods in Systems Biology</i> (Vol. 14137, pp. 18–35).
    Luxembourg City, Luxembourg: Springer Nature. <a href="https://doi.org/10.1007/978-3-031-42697-1_2">https://doi.org/10.1007/978-3-031-42697-1_2</a>'
  chicago: Beneš, Nikola, Luboš Brim, Samuel Pastva, David Šafránek, and Eva Šmijáková.
    “Phenotype Control of Partially Specified Boolean Networks.” In <i>21st International
    Conference on Computational Methods in Systems Biology</i>, 14137:18–35. Springer
    Nature, 2023. <a href="https://doi.org/10.1007/978-3-031-42697-1_2">https://doi.org/10.1007/978-3-031-42697-1_2</a>.
  ieee: N. Beneš, L. Brim, S. Pastva, D. Šafránek, and E. Šmijáková, “Phenotype control
    of partially specified boolean networks,” in <i>21st International Conference
    on Computational Methods in Systems Biology</i>, Luxembourg City, Luxembourg,
    2023, vol. 14137, pp. 18–35.
  ista: 'Beneš N, Brim L, Pastva S, Šafránek D, Šmijáková E. 2023. Phenotype control
    of partially specified boolean networks. 21st International Conference on Computational
    Methods in Systems Biology. CMSB: Computational Methods in Systems Biology, LNBI,
    vol. 14137, 18–35.'
  mla: Beneš, Nikola, et al. “Phenotype Control of Partially Specified Boolean Networks.”
    <i>21st International Conference on Computational Methods in Systems Biology</i>,
    vol. 14137, Springer Nature, 2023, pp. 18–35, doi:<a href="https://doi.org/10.1007/978-3-031-42697-1_2">10.1007/978-3-031-42697-1_2</a>.
  short: N. Beneš, L. Brim, S. Pastva, D. Šafránek, E. Šmijáková, in:, 21st International
    Conference on Computational Methods in Systems Biology, Springer Nature, 2023,
    pp. 18–35.
conference:
  end_date: 2023-09-15
  location: Luxembourg City, Luxembourg
  name: 'CMSB: Computational Methods in Systems Biology'
  start_date: 2023-09-13
date_created: 2023-10-08T22:01:18Z
date_published: 2023-09-09T00:00:00Z
date_updated: 2024-02-20T09:02:04Z
day: '09'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.1007/978-3-031-42697-1_2
ec_funded: 1
file:
- access_level: open_access
  checksum: 6f71bdaedb770b52380222fd9f4d7937
  content_type: application/pdf
  creator: spastva
  date_created: 2024-02-16T08:26:32Z
  date_updated: 2024-02-16T08:26:32Z
  file_id: '14997'
  file_name: cmsb2023.pdf
  file_size: 691582
  relation: main_file
  success: 1
file_date_updated: 2024-02-16T08:26:32Z
has_accepted_license: '1'
intvolume: '     14137'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Submitted Version
page: 18-35
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
  call_identifier: H2020
  grant_number: '101034413'
  name: 'IST-BRIDGE: International postdoctoral program'
publication: 21st International Conference on Computational Methods in Systems Biology
publication_identifier:
  eissn:
  - 1611-3349
  isbn:
  - '9783031426964'
  issn:
  - 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Phenotype control of partially specified boolean networks
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 14137
year: '2023'
...