---
_id: '6987'
abstract:
- lang: eng
  text: Cells are arranged into species-specific patterns during early embryogenesis.
    Such cell division patterns are important since they often reflect the distribution
    of localized cortical factors from eggs/fertilized eggs to specific cells as well
    as the emergence of organismal form. However, it has proven difficult to reveal
    the mechanisms that underlie the emergence of cell positioning patterns that underlie
    embryonic shape, likely because a systems-level approach is required that integrates
    cell biological, genetic, developmental, and mechanical parameters. The choice
    of organism to address such questions is also important. Because ascidians display
    the most extreme form of invariant cleavage pattern among the metazoans, we have
    been analyzing the cell biological mechanisms that underpin three aspects of cell
    division (unequal cell division (UCD), oriented cell division (OCD), and asynchronous
    cell cycles) which affect the overall shape of the blastula-stage ascidian embryo
    composed of 64 cells. In ascidians, UCD creates two small cells at the 16-cell
    stage that in turn undergo two further successive rounds of UCD. Starting at the
    16-cell stage, the cell cycle becomes asynchronous, whereby the vegetal half divides
    before the animal half, thus creating 24-, 32-, 44-, and then 64-cell stages.
    Perturbing either UCD or the alternate cell division rhythm perturbs cell position.
    We propose that dynamic cell shape changes propagate throughout the embryo via
    cell-cell contacts to create the ascidian-specific invariant cleavage pattern.
alternative_title:
- RESULTS
article_processing_charge: No
author:
- first_name: Alex
  full_name: McDougall, Alex
  last_name: McDougall
- first_name: Janet
  full_name: Chenevert, Janet
  last_name: Chenevert
- first_name: Benoit G
  full_name: Godard, Benoit G
  id: 33280250-F248-11E8-B48F-1D18A9856A87
  last_name: Godard
- first_name: Remi
  full_name: Dumollard, Remi
  last_name: Dumollard
citation:
  ama: 'McDougall A, Chenevert J, Godard BG, Dumollard R. Emergence of embryo shape
    during cleavage divisions. In: Tworzydlo W, Bilinski SM, eds. <i>Evo-Devo: Non-Model
    Species in Cell and Developmental Biology</i>. Vol 68. Springer Nature; 2019:127-154.
    doi:<a href="https://doi.org/10.1007/978-3-030-23459-1_6">10.1007/978-3-030-23459-1_6</a>'
  apa: 'McDougall, A., Chenevert, J., Godard, B. G., &#38; Dumollard, R. (2019). Emergence
    of embryo shape during cleavage divisions. In W. Tworzydlo &#38; S. M. Bilinski
    (Eds.), <i>Evo-Devo: Non-model species in cell and developmental biology</i> (Vol.
    68, pp. 127–154). Springer Nature. <a href="https://doi.org/10.1007/978-3-030-23459-1_6">https://doi.org/10.1007/978-3-030-23459-1_6</a>'
  chicago: 'McDougall, Alex, Janet Chenevert, Benoit G Godard, and Remi Dumollard.
    “Emergence of Embryo Shape during Cleavage Divisions.” In <i>Evo-Devo: Non-Model
    Species in Cell and Developmental Biology</i>, edited by Waclaw Tworzydlo and
    Szczepan M. Bilinski, 68:127–54. Springer Nature, 2019. <a href="https://doi.org/10.1007/978-3-030-23459-1_6">https://doi.org/10.1007/978-3-030-23459-1_6</a>.'
  ieee: 'A. McDougall, J. Chenevert, B. G. Godard, and R. Dumollard, “Emergence of
    embryo shape during cleavage divisions,” in <i>Evo-Devo: Non-model species in
    cell and developmental biology</i>, vol. 68, W. Tworzydlo and S. M. Bilinski,
    Eds. Springer Nature, 2019, pp. 127–154.'
  ista: 'McDougall A, Chenevert J, Godard BG, Dumollard R. 2019.Emergence of embryo
    shape during cleavage divisions. In: Evo-Devo: Non-model species in cell and developmental
    biology. RESULTS, vol. 68, 127–154.'
  mla: 'McDougall, Alex, et al. “Emergence of Embryo Shape during Cleavage Divisions.”
    <i>Evo-Devo: Non-Model Species in Cell and Developmental Biology</i>, edited by
    Waclaw Tworzydlo and Szczepan M. Bilinski, vol. 68, Springer Nature, 2019, pp.
    127–54, doi:<a href="https://doi.org/10.1007/978-3-030-23459-1_6">10.1007/978-3-030-23459-1_6</a>.'
  short: 'A. McDougall, J. Chenevert, B.G. Godard, R. Dumollard, in:, W. Tworzydlo,
    S.M. Bilinski (Eds.), Evo-Devo: Non-Model Species in Cell and Developmental Biology,
    Springer Nature, 2019, pp. 127–154.'
date_created: 2019-11-04T16:20:19Z
date_published: 2019-10-10T00:00:00Z
date_updated: 2023-09-05T15:01:12Z
day: '10'
ddc:
- '570'
department:
- _id: CaHe
doi: 10.1007/978-3-030-23459-1_6
editor:
- first_name: Waclaw
  full_name: Tworzydlo, Waclaw
  last_name: Tworzydlo
- first_name: Szczepan M.
  full_name: Bilinski, Szczepan M.
  last_name: Bilinski
external_id:
  pmid:
  - '31598855'
file:
- access_level: open_access
  checksum: 7f43e1e3706d15061475c5c57efc2786
  content_type: application/pdf
  creator: dernst
  date_created: 2020-05-14T10:09:30Z
  date_updated: 2020-07-14T12:47:46Z
  file_id: '7829'
  file_name: 2019_RESULTS_McDougall.pdf
  file_size: 19317348
  relation: main_file
file_date_updated: 2020-07-14T12:47:46Z
has_accepted_license: '1'
intvolume: '        68'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Submitted Version
page: 127-154
pmid: 1
publication: 'Evo-Devo: Non-model species in cell and developmental biology'
publication_identifier:
  eissn:
  - 1861-0412
  isbn:
  - '9783030234584'
  - '9783030234591'
  issn:
  - 0080-1844
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Emergence of embryo shape during cleavage divisions
type: book_chapter
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 68
year: '2019'
...