---
_id: '47'
abstract:
- lang: eng
text: Plant hormones as signalling molecules play an essential role in the control
of plant growth and development. Typically, sites of hormonal action are usually
distant from the site of biosynthesis thus relying on efficient transport mechanisms.
Over the last decades, molecular identification of proteins and protein complexes
involved in hormonal transport has started. Advanced screens for genes involved
in hormonal transport in combination with transport assays using heterologous
systems such as yeast, insect, or tobacco BY2 cells or Xenopus oocytes provided
important insights into mechanisms underlying distribution of hormones in plant
body and led to identification of principal transporters for each hormone. This
review gives a short overview of the mechanisms of hormonal transport and transporters
identified in Arabidopsis thaliana.
article_processing_charge: No
author:
- first_name: Rashed
full_name: Abualia, Rashed
id: 4827E134-F248-11E8-B48F-1D18A9856A87
last_name: Abualia
orcid: 0000-0002-9357-9415
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
- first_name: Benoît
full_name: Lacombe, Benoît
last_name: Lacombe
citation:
ama: Abualia R, Benková E, Lacombe B. Transporters and mechanisms of hormone transport
in arabidopsis. Advances in Botanical Research. 2018;87:115-138. doi:10.1016/bs.abr.2018.09.007
apa: Abualia, R., Benková, E., & Lacombe, B. (2018). Transporters and mechanisms
of hormone transport in arabidopsis. Advances in Botanical Research. Elsevier.
https://doi.org/10.1016/bs.abr.2018.09.007
chicago: Abualia, Rashed, Eva Benková, and Benoît Lacombe. “Transporters and Mechanisms
of Hormone Transport in Arabidopsis.” Advances in Botanical Research. Elsevier,
2018. https://doi.org/10.1016/bs.abr.2018.09.007.
ieee: R. Abualia, E. Benková, and B. Lacombe, “Transporters and mechanisms of hormone
transport in arabidopsis,” Advances in Botanical Research, vol. 87. Elsevier,
pp. 115–138, 2018.
ista: Abualia R, Benková E, Lacombe B. 2018. Transporters and mechanisms of hormone
transport in arabidopsis. Advances in Botanical Research. 87, 115–138.
mla: Abualia, Rashed, et al. “Transporters and Mechanisms of Hormone Transport in
Arabidopsis.” Advances in Botanical Research, vol. 87, Elsevier, 2018,
pp. 115–38, doi:10.1016/bs.abr.2018.09.007.
short: R. Abualia, E. Benková, B. Lacombe, Advances in Botanical Research 87 (2018)
115–138.
date_created: 2018-12-11T11:44:20Z
date_published: 2018-01-01T00:00:00Z
date_updated: 2024-03-25T23:30:22Z
day: '01'
department:
- _id: EvBe
doi: 10.1016/bs.abr.2018.09.007
external_id:
isi:
- '000453657800006'
intvolume: ' 87'
isi: 1
language:
- iso: eng
month: '01'
oa_version: None
page: 115 - 138
publication: Advances in Botanical Research
publication_status: published
publisher: Elsevier
publist_id: '8007'
quality_controlled: '1'
related_material:
record:
- id: '10303'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Transporters and mechanisms of hormone transport in arabidopsis
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 87
year: '2018'
...
---
_id: '48'
abstract:
- lang: eng
text: 'The hippocampus is a key brain region for spatial memory and navigation and
is needed at all stages of memory, including encoding, consolidation, and recall.
Hippocampal place cells selectively discharge at specific locations of the environment
to form a cognitive map of the space. During the rest period and sleep following
spatial navigation and/or learning, the waking activity of the place cells is
reactivated within high synchrony events. This reactivation is thought to be important
for memory consolidation and stabilization of the spatial representations. The
aim of my thesis was to directly test whether the reactivation content encoded
in firing patterns of place cells is important for consolidation of spatial memories.
In particular, I aimed to test whether, in cases when multiple spatial memory
traces are acquired during learning, the specific disruption of the reactivation
of a subset of these memories leads to the selective disruption of the corresponding
memory traces or through memory interference the other learned memories are disrupted
as well. In this thesis, using a modified cheeseboard paradigm and a closed-loop
recording setup with feedback optogenetic stimulation, I examined how the disruption
of the reactivation of specific spiking patterns affects consolidation of the
corresponding memory traces. To obtain multiple distinctive memories, animals
had to perform a spatial task in two distinct cheeseboard environments and the
reactivation of spiking patterns associated with one of the environments (target)
was disrupted after learning during four hours rest period using a real-time decoding
method. This real-time decoding method was capable of selectively affecting the
firing rates and cofiring correlations of the target environment-encoding cells.
The selective disruption led to behavioural impairment in the memory tests after
the rest periods in the target environment but not in the other undisrupted control
environment. In addition, the map of the target environment was less stable in
the impaired memory tests compared to the learning session before than the map
of the control environment. However, when the animal relearned the task, the same
map recurred in the target environment that was present during learning before
the disruption. Altogether my work demonstrated that the reactivation content
is important: assembly-related disruption of reactivation can lead to a selective
memory impairment and deficiency in map stability. These findings indeed suggest
that reactivated assembly patterns reflect processes associated with the consolidation
of memory traces. '
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Igor
full_name: Gridchyn, Igor
id: 4B60654C-F248-11E8-B48F-1D18A9856A87
last_name: Gridchyn
orcid: 0000-0002-1807-1929
citation:
ama: Gridchyn I. Reactivation content is important for consolidation of spatial
memory. 2018. doi:10.15479/AT:ISTA:th_1042
apa: Gridchyn, I. (2018). Reactivation content is important for consolidation
of spatial memory. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:th_1042
chicago: Gridchyn, Igor. “Reactivation Content Is Important for Consolidation of
Spatial Memory.” Institute of Science and Technology Austria, 2018. https://doi.org/10.15479/AT:ISTA:th_1042.
ieee: I. Gridchyn, “Reactivation content is important for consolidation of spatial
memory,” Institute of Science and Technology Austria, 2018.
ista: Gridchyn I. 2018. Reactivation content is important for consolidation of spatial
memory. Institute of Science and Technology Austria.
mla: Gridchyn, Igor. Reactivation Content Is Important for Consolidation of Spatial
Memory. Institute of Science and Technology Austria, 2018, doi:10.15479/AT:ISTA:th_1042.
short: I. Gridchyn, Reactivation Content Is Important for Consolidation of Spatial
Memory, Institute of Science and Technology Austria, 2018.
date_created: 2018-12-11T11:44:21Z
date_published: 2018-08-27T00:00:00Z
date_updated: 2023-09-07T12:42:44Z
day: '27'
ddc:
- '573'
degree_awarded: PhD
department:
- _id: JoCs
doi: 10.15479/AT:ISTA:th_1042
file:
- access_level: closed
checksum: 7db4415e435590fa33542c7b0a0321d7
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: dernst
date_created: 2019-04-08T13:36:01Z
date_updated: 2021-02-11T23:30:22Z
embargo_to: open_access
file_id: '6236'
file_name: 2018_Thesis_Gridchyn_source.docx
file_size: 7666687
relation: source_file
- access_level: open_access
checksum: f96f3fe8979f7b1e6db6acaca962b10c
content_type: application/pdf
creator: dernst
date_created: 2019-04-08T13:36:01Z
date_updated: 2021-02-11T11:17:18Z
embargo: 2019-08-29
file_id: '6237'
file_name: 2018_Thesis_Gridchyn.pdf
file_size: 6034153
relation: main_file
file_date_updated: 2021-02-11T23:30:22Z
has_accepted_license: '1'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '08'
oa: 1
oa_version: Published Version
page: '104'
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
publist_id: '8006'
pubrep_id: '1042'
status: public
supervisor:
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
title: Reactivation content is important for consolidation of spatial memory
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2018'
...
---
_id: '49'
abstract:
- lang: eng
text: Nowadays, quantum computation is receiving more and more attention as an alternative
to the classical way of computing. For realizing a quantum computer, different
devices are investigated as potential quantum bits. In this thesis, the focus
is on Ge hut wires, which turned out to be promising candidates for implementing
hole spin quantum bits. The advantages of Ge as a material system are the low
hyperfine interaction for holes and the strong spin orbit coupling, as well as
the compatibility with the highly developed CMOS processes in industry. In addition,
Ge can also be isotopically purified which is expected to boost the spin coherence
times. The strong spin orbit interaction for holes in Ge on the one hand enables
the full electrical control of the quantum bit and on the other hand should allow
short spin manipulation times. Starting with a bare Si wafer, this work covers
the entire process reaching from growth over the fabrication and characterization
of hut wire devices up to the demonstration of hole spin resonance. From experiments
with single quantum dots, a large g-factor anisotropy between the in-plane and
the out-of-plane direction was found. A comparison to a theoretical model unveiled
the heavy-hole character of the lowest energy states. The second part of the thesis
addresses double quantum dot devices, which were realized by adding two gate electrodes
to a hut wire. In such devices, Pauli spin blockade was observed, which can serve
as a read-out mechanism for spin quantum bits. Applying oscillating electric fields
in spin blockade allowed the demonstration of continuous spin rotations and the
extraction of a lower bound for the spin dephasing time. Despite the strong spin
orbit coupling in Ge, the obtained value for the dephasing time is comparable
to what has been recently reported for holes in Si. All in all, the presented
results point out the high potential of Ge hut wires as a platform for long-lived,
fast and fully electrically tunable hole spin quantum bits.
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Hannes
full_name: Watzinger, Hannes
id: 35DF8E50-F248-11E8-B48F-1D18A9856A87
last_name: Watzinger
citation:
ama: Watzinger H. Ge hut wires - from growth to hole spin resonance. 2018. doi:10.15479/AT:ISTA:th_1033
apa: Watzinger, H. (2018). Ge hut wires - from growth to hole spin resonance.
Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:th_1033
chicago: Watzinger, Hannes. “Ge Hut Wires - from Growth to Hole Spin Resonance.”
Institute of Science and Technology Austria, 2018. https://doi.org/10.15479/AT:ISTA:th_1033.
ieee: H. Watzinger, “Ge hut wires - from growth to hole spin resonance,” Institute
of Science and Technology Austria, 2018.
ista: Watzinger H. 2018. Ge hut wires - from growth to hole spin resonance. Institute
of Science and Technology Austria.
mla: Watzinger, Hannes. Ge Hut Wires - from Growth to Hole Spin Resonance.
Institute of Science and Technology Austria, 2018, doi:10.15479/AT:ISTA:th_1033.
short: H. Watzinger, Ge Hut Wires - from Growth to Hole Spin Resonance, Institute
of Science and Technology Austria, 2018.
date_created: 2018-12-11T11:44:21Z
date_published: 2018-07-30T00:00:00Z
date_updated: 2023-09-07T12:27:43Z
day: '30'
ddc:
- '530'
degree_awarded: PhD
department:
- _id: GeKa
doi: 10.15479/AT:ISTA:th_1033
file:
- access_level: open_access
checksum: b653b5216251f938ddbeafd1de88667c
content_type: application/pdf
creator: dernst
date_created: 2019-04-09T07:13:28Z
date_updated: 2020-07-14T12:46:35Z
file_id: '6249'
file_name: 2018_Thesis_Watzinger.pdf
file_size: 85539748
relation: main_file
- access_level: closed
checksum: 39bcf8de7ac5b1bb516b11ce2f966785
content_type: application/zip
creator: dernst
date_created: 2019-04-09T07:13:27Z
date_updated: 2020-07-14T12:46:35Z
file_id: '6250'
file_name: 2018_Thesis_Watzinger_source.zip
file_size: 21830697
relation: source_file
file_date_updated: 2020-07-14T12:46:35Z
has_accepted_license: '1'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: '77'
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
publist_id: '8005'
pubrep_id: '1033'
status: public
supervisor:
- first_name: Georgios
full_name: Katsaros, Georgios
id: 38DB5788-F248-11E8-B48F-1D18A9856A87
last_name: Katsaros
orcid: 0000-0001-8342-202X
title: Ge hut wires - from growth to hole spin resonance
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2018'
...
---
_id: '50'
abstract:
- lang: eng
text: The Wnt/planar cell polarity (Wnt/PCP) pathway determines planar polarity
of epithelial cells in both vertebrates and invertebrates. The role that Wnt/PCP
signaling plays in mesenchymal contexts, however, is only poorly understood. While
previous studies have demonstrated the capacity of Wnt/PCP signaling to polarize
and guide directed migration of mesenchymal cells, it remains unclear whether
endogenous Wnt/PCP signaling performs these functions instructively, as it does
in epithelial cells. Here we developed a light-switchable version of the Wnt/PCP
receptor Frizzled 7 (Fz7) to unambiguously distinguish between an instructive
and a permissive role of Wnt/PCP signaling for the directional collective migration
of mesendoderm progenitor cells during zebrafish gastrulation. We show that prechordal
plate (ppl) cell migration is defective in maternal-zygotic fz7a and fz7b (MZ
fz7a,b) double mutant embryos, and that Fz7 functions cell-autonomously in this
process by promoting ppl cell protrusion formation and directed migration. We
further show that local activation of Fz7 can direct ppl cell migration both in
vitro and in vivo. Surprisingly, however, uniform Fz7 activation is sufficient
to fully rescue the ppl cell migration defect in MZ fz7a,b mutant embryos, indicating
that Wnt/PCP signaling functions permissively rather than instructively in directed
mesendoderm cell migration during zebrafish gastrulation.
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Daniel
full_name: Capek, Daniel
id: 31C42484-F248-11E8-B48F-1D18A9856A87
last_name: Capek
orcid: 0000-0001-5199-9940
citation:
ama: Capek D. Optogenetic Frizzled 7 reveals a permissive function of Wnt/PCP signaling
in directed mesenchymal cell migration. 2018. doi:10.15479/AT:ISTA:TH_1031
apa: Capek, D. (2018). Optogenetic Frizzled 7 reveals a permissive function of
Wnt/PCP signaling in directed mesenchymal cell migration. Institute of Science
and Technology Austria. https://doi.org/10.15479/AT:ISTA:TH_1031
chicago: Capek, Daniel. “Optogenetic Frizzled 7 Reveals a Permissive Function of
Wnt/PCP Signaling in Directed Mesenchymal Cell Migration.” Institute of Science
and Technology Austria, 2018. https://doi.org/10.15479/AT:ISTA:TH_1031.
ieee: D. Capek, “Optogenetic Frizzled 7 reveals a permissive function of Wnt/PCP
signaling in directed mesenchymal cell migration,” Institute of Science and Technology
Austria, 2018.
ista: Capek D. 2018. Optogenetic Frizzled 7 reveals a permissive function of Wnt/PCP
signaling in directed mesenchymal cell migration. Institute of Science and Technology
Austria.
mla: Capek, Daniel. Optogenetic Frizzled 7 Reveals a Permissive Function of Wnt/PCP
Signaling in Directed Mesenchymal Cell Migration. Institute of Science and
Technology Austria, 2018, doi:10.15479/AT:ISTA:TH_1031.
short: D. Capek, Optogenetic Frizzled 7 Reveals a Permissive Function of Wnt/PCP
Signaling in Directed Mesenchymal Cell Migration, Institute of Science and Technology
Austria, 2018.
date_created: 2018-12-11T11:44:21Z
date_published: 2018-06-22T00:00:00Z
date_updated: 2023-09-07T12:48:16Z
day: '22'
ddc:
- '570'
- '591'
- '596'
degree_awarded: PhD
department:
- _id: CaHe
doi: 10.15479/AT:ISTA:TH_1031
file:
- access_level: open_access
checksum: d3eca3dcacb67bffdde6e6609c31cdd0
content_type: application/pdf
creator: dernst
date_created: 2019-04-08T13:42:26Z
date_updated: 2021-02-11T11:17:17Z
embargo: 2019-06-25
file_id: '6238'
file_name: 2018_Thesis_Capek.pdf
file_size: 31576521
relation: main_file
- access_level: closed
checksum: 876deb14067e638aba65d209668bd821
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: dernst
date_created: 2019-04-08T13:42:27Z
date_updated: 2021-02-11T23:30:21Z
embargo_to: open_access
file_id: '6239'
file_name: 2018_Thesis_Capek_source.docx
file_size: 38992956
relation: source_file
file_date_updated: 2021-02-11T23:30:21Z
has_accepted_license: '1'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: '95'
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
publist_id: '8004'
pubrep_id: '1031'
related_material:
record:
- id: '1100'
relation: part_of_dissertation
status: public
- id: '661'
relation: part_of_dissertation
status: public
- id: '676'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
title: Optogenetic Frizzled 7 reveals a permissive function of Wnt/PCP signaling in
directed mesenchymal cell migration
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2018'
...
---
_id: '503'
abstract:
- lang: eng
text: Buffers are essential for diluting bacterial cultures for flow cytometry analysis
in order to study bacterial physiology and gene expression parameters based on
fluorescence signals. Using a variety of constitutively expressed fluorescent
proteins in Escherichia coli K-12 strain MG1655, we found strong artifactual changes
in fluorescence levels after dilution into the commonly used flow cytometry buffer
phosphate-buffered saline (PBS) and two other buffer solutions, Tris-HCl and M9
salts. These changes appeared very rapidly after dilution, and were linked to
increased membrane permeability and loss in cell viability. We observed buffer-related
effects in several different E. coli strains, K-12, C and W, but not E. coli B,
which can be partially explained by differences in lipopolysaccharide (LPS) and
outer membrane composition. Supplementing the buffers with divalent cations responsible
for outer membrane stability, Mg2+ and Ca2+, preserved fluorescence signals, membrane
integrity and viability of E. coli. Thus, stabilizing the bacterial outer membrane
is essential for precise and unbiased measurements of fluorescence parameters
using flow cytometry.
acknowledged_ssus:
- _id: Bio
acknowledgement: "We thank R Chait and M Lagator for sharing Bacillus subtilis CR_Y1
and pZS*_2R-cIPtet-Venus-Prm, respectively. We are grateful to T Pilizota and all
members of the Guet lab for critically reading the manuscript. We also thank the
Bioimaging facility at IST Austria for assistance using the FACSAria III system.\r\n\r\n"
article_processing_charge: No
author:
- first_name: Kathrin
full_name: Tomasek, Kathrin
id: 3AEC8556-F248-11E8-B48F-1D18A9856A87
last_name: Tomasek
orcid: 0000-0003-3768-877X
- first_name: Tobias
full_name: Bergmiller, Tobias
id: 2C471CFA-F248-11E8-B48F-1D18A9856A87
last_name: Bergmiller
orcid: 0000-0001-5396-4346
- first_name: Calin C
full_name: Guet, Calin C
id: 47F8433E-F248-11E8-B48F-1D18A9856A87
last_name: Guet
orcid: 0000-0001-6220-2052
citation:
ama: Tomasek K, Bergmiller T, Guet CC. Lack of cations in flow cytometry buffers
affect fluorescence signals by reducing membrane stability and viability of Escherichia
coli strains. Journal of Biotechnology. 2018;268:40-52. doi:10.1016/j.jbiotec.2018.01.008
apa: Tomasek, K., Bergmiller, T., & Guet, C. C. (2018). Lack of cations in flow
cytometry buffers affect fluorescence signals by reducing membrane stability and
viability of Escherichia coli strains. Journal of Biotechnology. Elsevier.
https://doi.org/10.1016/j.jbiotec.2018.01.008
chicago: Tomasek, Kathrin, Tobias Bergmiller, and Calin C Guet. “Lack of Cations
in Flow Cytometry Buffers Affect Fluorescence Signals by Reducing Membrane Stability
and Viability of Escherichia Coli Strains.” Journal of Biotechnology. Elsevier,
2018. https://doi.org/10.1016/j.jbiotec.2018.01.008.
ieee: K. Tomasek, T. Bergmiller, and C. C. Guet, “Lack of cations in flow cytometry
buffers affect fluorescence signals by reducing membrane stability and viability
of Escherichia coli strains,” Journal of Biotechnology, vol. 268. Elsevier,
pp. 40–52, 2018.
ista: Tomasek K, Bergmiller T, Guet CC. 2018. Lack of cations in flow cytometry
buffers affect fluorescence signals by reducing membrane stability and viability
of Escherichia coli strains. Journal of Biotechnology. 268, 40–52.
mla: Tomasek, Kathrin, et al. “Lack of Cations in Flow Cytometry Buffers Affect
Fluorescence Signals by Reducing Membrane Stability and Viability of Escherichia
Coli Strains.” Journal of Biotechnology, vol. 268, Elsevier, 2018, pp.
40–52, doi:10.1016/j.jbiotec.2018.01.008.
short: K. Tomasek, T. Bergmiller, C.C. Guet, Journal of Biotechnology 268 (2018)
40–52.
date_created: 2018-12-11T11:46:50Z
date_published: 2018-02-20T00:00:00Z
date_updated: 2023-09-13T08:24:51Z
day: '20'
department:
- _id: CaGu
doi: 10.1016/j.jbiotec.2018.01.008
external_id:
isi:
- '000425715100006'
intvolume: ' 268'
isi: 1
language:
- iso: eng
month: '02'
oa_version: None
page: 40 - 52
publication: Journal of Biotechnology
publication_status: published
publisher: Elsevier
publist_id: '7317'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Lack of cations in flow cytometry buffers affect fluorescence signals by reducing
membrane stability and viability of Escherichia coli strains
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 268
year: '2018'
...
---
_id: '51'
abstract:
- lang: eng
text: Asymmetries have long been known about in the central nervous system. From
gross anatomical differences, such as the presence of the parapineal organ in
only one hemisphere of the developing zebrafish, to more subtle differences in
activity between both hemispheres, as seen in freely roaming animals or human
participants under PET and fMRI imaging analysis. The presence of asymmetries
has been demonstrated to have huge behavioural implications, with their disruption
often leading to the generation of neurological disorders, memory problems, changes
in personality, and in an organism's health and well-being. For my Ph.D. work
I aimed to tackle two important avenues of research. The first being the process
of input-side dependency in the hippocampus, with the goal of finding a key gene
responsible for its development (Gene X). The second project was to do with experience-induced
laterality formation in the hippocampus. Specifically, how laterality in the synapse
density of the CA1 stratum radiatum (s.r.) could be induced purely through environmental
enrichment. Through unilateral tracer injections into the CA3, I was able to selectively
measure the properties of synapses within the CA1 and investigate how they differed
based upon which hemisphere the presynaptic neurone originated. Having found the
existence of a previously unreported reversed (left-isomerism) i.v. mutant, through
morpholocal examination of labelled terminals in the CA1 s.r., I aimed to elucidate
a key gene responsible for the process of left or right determination of inputs
to the CA1 s.r.. This work relates to the previous finding of input-side dependent
asymmetry in the wild-type rodent, where the origin of the projecting neurone
to the CA1 will determine the morphology of a synapse, to a greater degree than
the hemisphere in which the projection terminates. Using left- and right-isomerism
i.v. mice, in combination with whole genome sequence analysis, I highlight Ena/VASP-like
(Evl) as a potential target for Gene X. In relation to this topic, I also highlight
my work in the recently published paper of how knockout of PirB can lead to a
lack of input-side dependency in the murine hippocampus. For the second question,
I show that the environmental enrichment paradigm will lead to an asymmetry in
the synapse densities in the hippocampus of mice. I also highlight that the nature
of the enrichment is of less consequence than the process of enrichment itself.
I demonstrate that the CA3 region will dramatically alter its projection targets,
in relation to environmental stimulation, with the asymmetry in synaptic density,
caused by enrichment, relying heavily on commissural fibres. I also highlight
the vital importance of input-side dependent asymmetry, as a necessary component
of experience-dependent laterality formation in the CA1 s.r.. However, my results
suggest that it isn't the only cause, as there appears to be a CA1 dependent mechanism
also at play. Upon further investigation, I highlight the significant, and highly
important, finding that the changes seen in the CA1 s.r. were predominantly caused
through projections from the left-CA3, with the right-CA3 having less involvement
in this mechanism.
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Matthew J
full_name: Case, Matthew J
id: 44B7CA5A-F248-11E8-B48F-1D18A9856A87
last_name: Case
citation:
ama: 'Case MJ. From the left to the right: A tale of asymmetries, environments,
and hippocampal development. 2018. doi:10.15479/AT:ISTA:th_1032'
apa: 'Case, M. J. (2018). From the left to the right: A tale of asymmetries,
environments, and hippocampal development. Institute of Science and Technology
Austria. https://doi.org/10.15479/AT:ISTA:th_1032'
chicago: 'Case, Matthew J. “From the Left to the Right: A Tale of Asymmetries, Environments,
and Hippocampal Development.” Institute of Science and Technology Austria, 2018.
https://doi.org/10.15479/AT:ISTA:th_1032.'
ieee: 'M. J. Case, “From the left to the right: A tale of asymmetries, environments,
and hippocampal development,” Institute of Science and Technology Austria, 2018.'
ista: 'Case MJ. 2018. From the left to the right: A tale of asymmetries, environments,
and hippocampal development. Institute of Science and Technology Austria.'
mla: 'Case, Matthew J. From the Left to the Right: A Tale of Asymmetries, Environments,
and Hippocampal Development. Institute of Science and Technology Austria,
2018, doi:10.15479/AT:ISTA:th_1032.'
short: 'M.J. Case, From the Left to the Right: A Tale of Asymmetries, Environments,
and Hippocampal Development, Institute of Science and Technology Austria, 2018.'
date_created: 2018-12-11T11:44:22Z
date_published: 2018-06-27T00:00:00Z
date_updated: 2023-09-07T12:39:22Z
day: '27'
ddc:
- '571'
- '576'
degree_awarded: PhD
department:
- _id: RySh
doi: 10.15479/AT:ISTA:th_1032
file:
- access_level: closed
checksum: dcc7b55619d8509dd62b8e99d6cdee44
content_type: application/msword
creator: dernst
date_created: 2019-04-09T07:16:26Z
date_updated: 2021-02-11T23:30:13Z
embargo_to: open_access
file_id: '6251'
file_name: 2018_Thesis_Case_Source.doc
file_size: 141270528
relation: source_file
- access_level: open_access
checksum: f69fdd5c8709c4e618aa8c1a1221153d
content_type: application/pdf
creator: dernst
date_created: 2019-04-09T07:16:23Z
date_updated: 2021-02-11T11:17:14Z
embargo: 2019-07-05
file_id: '6252'
file_name: 2018_Thesis_Case.pdf
file_size: 15193621
relation: main_file
file_date_updated: 2021-02-11T23:30:13Z
has_accepted_license: '1'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: '186'
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
publist_id: '8003'
pubrep_id: '1032'
related_material:
record:
- id: '682'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
title: 'From the left to the right: A tale of asymmetries, environments, and hippocampal
development'
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2018'
...
---
_id: '519'
abstract:
- lang: eng
text: 'This study treats with the influence of a symmetry-breaking transversal magnetic
field on the nonlinear dynamics of ferrofluidic Taylor-Couette flow – flow confined
between two concentric independently rotating cylinders. We detected alternating
‘flip’ solutions which are flow states featuring typical characteristics of slow-fast-dynamics
in dynamical systems. The flip corresponds to a temporal change in the axial wavenumber
and we find them to appear either as pure 2-fold axisymmetric (due to the symmetry-breaking
nature of the applied transversal magnetic field) or involving non-axisymmetric,
helical modes in its interim solution. The latter ones show features of typical
ribbon solutions. In any case the flip solutions have a preferential first axial
wavenumber which corresponds to the more stable state (slow dynamics) and second
axial wavenumber, corresponding to the short appearing more unstable state (fast
dynamics). However, in both cases the flip time grows exponential with increasing
the magnetic field strength before the flip solutions, living on 2-tori invariant
manifolds, cease to exist, with lifetime going to infinity. Further we show that
ferrofluidic flow turbulence differ from the classical, ordinary (usually at high
Reynolds number) turbulence. The applied magnetic field hinders the free motion
of ferrofluid partials and therefore smoothen typical turbulent quantities and
features so that speaking of mildly chaotic dynamics seems to be a more appropriate
expression for the observed motion. '
acknowledgement: S.Altmeyer is a Serra Húnter Fellow
article_processing_charge: No
article_type: original
author:
- first_name: Sebastian
full_name: Altmeyer, Sebastian
id: 2EE67FDC-F248-11E8-B48F-1D18A9856A87
last_name: Altmeyer
orcid: 0000-0001-5964-0203
citation:
ama: Altmeyer S. Non-linear dynamics and alternating ‘flip’ solutions in ferrofluidic
Taylor-Couette flow. Journal of Magnetism and Magnetic Materials. 2018;452:427-441.
doi:10.1016/j.jmmm.2017.12.073
apa: Altmeyer, S. (2018). Non-linear dynamics and alternating ‘flip’ solutions in
ferrofluidic Taylor-Couette flow. Journal of Magnetism and Magnetic Materials.
Elsevier. https://doi.org/10.1016/j.jmmm.2017.12.073
chicago: Altmeyer, Sebastian. “Non-Linear Dynamics and Alternating ‘Flip’ Solutions
in Ferrofluidic Taylor-Couette Flow.” Journal of Magnetism and Magnetic Materials.
Elsevier, 2018. https://doi.org/10.1016/j.jmmm.2017.12.073.
ieee: S. Altmeyer, “Non-linear dynamics and alternating ‘flip’ solutions in ferrofluidic
Taylor-Couette flow,” Journal of Magnetism and Magnetic Materials, vol.
452. Elsevier, pp. 427–441, 2018.
ista: Altmeyer S. 2018. Non-linear dynamics and alternating ‘flip’ solutions in
ferrofluidic Taylor-Couette flow. Journal of Magnetism and Magnetic Materials.
452, 427–441.
mla: Altmeyer, Sebastian. “Non-Linear Dynamics and Alternating ‘Flip’ Solutions
in Ferrofluidic Taylor-Couette Flow.” Journal of Magnetism and Magnetic Materials,
vol. 452, Elsevier, 2018, pp. 427–41, doi:10.1016/j.jmmm.2017.12.073.
short: S. Altmeyer, Journal of Magnetism and Magnetic Materials 452 (2018) 427–441.
date_created: 2018-12-11T11:46:56Z
date_published: 2018-04-15T00:00:00Z
date_updated: 2023-09-13T09:03:44Z
day: '15'
ddc:
- '530'
department:
- _id: BjHo
doi: 10.1016/j.jmmm.2017.12.073
external_id:
isi:
- '000425547700061'
file:
- access_level: open_access
checksum: 431f5cd4a628d7ca21161f82b14ccb4f
content_type: application/pdf
creator: dernst
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date_updated: 2020-07-14T12:46:37Z
file_id: '7838'
file_name: 2018_Magnetism_Altmeyer.pdf
file_size: 17309535
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file_date_updated: 2020-07-14T12:46:37Z
has_accepted_license: '1'
intvolume: ' 452'
isi: 1
language:
- iso: eng
month: '04'
oa: 1
oa_version: Submitted Version
page: 427 - 441
publication: Journal of Magnetism and Magnetic Materials
publication_status: published
publisher: Elsevier
publist_id: '7297'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Non-linear dynamics and alternating ‘flip’ solutions in ferrofluidic Taylor-Couette
flow
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 452
year: '2018'
...
---
_id: '52'
abstract:
- lang: eng
text: In this thesis we will discuss systems of point interacting fermions, their
stability and other spectral properties. Whereas for bosons a point interacting
system is always unstable this ques- tion is more subtle for a gas of two species
of fermions. In particular the answer depends on the mass ratio between these
two species. Most of this work will be focused on the N + M model which consists
of two species of fermions with N, M particles respectively which interact via
point interactions. We will introduce this model using a formal limit and discuss
the N + 1 system in more detail. In particular, we will show that for mass ratios
above a critical one, which does not depend on the particle number, the N + 1
system is stable. In the context of this model we will prove rigorous versions
of Tan relations which relate various quantities of the point-interacting model.
By restricting the N + 1 system to a box we define a finite density model with
point in- teractions. In the context of this system we will discuss the energy
change when introducing a point-interacting impurity into a system of non-interacting
fermions. We will see that this change in energy is bounded independently of the
particle number and in particular the bound only depends on the density and the
scattering length. As another special case of the N + M model we will show stability
of the 2 + 2 model for mass ratios in an interval around one. Further we will
investigate a different model of point interactions which was discussed before
in the literature and which is, contrary to the N + M model, not given by a limiting
procedure but is based on a Dirichlet form. We will show that this system behaves
trivially in the thermodynamic limit, i.e. the free energy per particle is the
same as the one of the non-interacting system.
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Thomas
full_name: Moser, Thomas
id: 2B5FC9A4-F248-11E8-B48F-1D18A9856A87
last_name: Moser
citation:
ama: Moser T. Point interactions in systems of fermions. 2018. doi:10.15479/AT:ISTA:th_1043
apa: Moser, T. (2018). Point interactions in systems of fermions. Institute
of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:th_1043
chicago: Moser, Thomas. “Point Interactions in Systems of Fermions.” Institute of
Science and Technology Austria, 2018. https://doi.org/10.15479/AT:ISTA:th_1043.
ieee: T. Moser, “Point interactions in systems of fermions,” Institute of Science
and Technology Austria, 2018.
ista: Moser T. 2018. Point interactions in systems of fermions. Institute of Science
and Technology Austria.
mla: Moser, Thomas. Point Interactions in Systems of Fermions. Institute
of Science and Technology Austria, 2018, doi:10.15479/AT:ISTA:th_1043.
short: T. Moser, Point Interactions in Systems of Fermions, Institute of Science
and Technology Austria, 2018.
date_created: 2018-12-11T11:44:22Z
date_published: 2018-09-04T00:00:00Z
date_updated: 2023-09-27T12:34:14Z
day: '04'
ddc:
- '515'
- '530'
- '519'
degree_awarded: PhD
department:
- _id: RoSe
doi: 10.15479/AT:ISTA:th_1043
file:
- access_level: open_access
checksum: fbd8c747d148b468a21213b7cf175225
content_type: application/pdf
creator: dernst
date_created: 2019-04-09T07:45:38Z
date_updated: 2020-07-14T12:46:37Z
file_id: '6256'
file_name: 2018_Thesis_Moser.pdf
file_size: 851164
relation: main_file
- access_level: closed
checksum: c28e16ecfc1126d3ce324ec96493c01e
content_type: application/zip
creator: dernst
date_created: 2019-04-09T07:45:38Z
date_updated: 2020-07-14T12:46:37Z
file_id: '6257'
file_name: 2018_Thesis_Moser_Source.zip
file_size: 1531516
relation: source_file
file_date_updated: 2020-07-14T12:46:37Z
has_accepted_license: '1'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: '115'
project:
- _id: 25C878CE-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P27533_N27
name: Structure of the Excitation Spectrum for Many-Body Quantum Systems
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
publist_id: '8002'
pubrep_id: '1043'
related_material:
record:
- id: '5856'
relation: part_of_dissertation
status: public
- id: '154'
relation: part_of_dissertation
status: public
- id: '1198'
relation: part_of_dissertation
status: public
- id: '741'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
title: Point interactions in systems of fermions
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2018'
...
---
_id: '53'
abstract:
- lang: eng
text: In 2013, a publication repository was implemented at IST Austria and 2015
after a thorough preparation phase a data repository was implemented - both based
on the Open Source Software EPrints. In this text, designed as field report, we
will reflect on our experiences with Open Source Software in general and specifically
with EPrints regarding technical aspects but also regarding their characteristics
of the user community. The second part is a pleading for including the end users
in the process of implementation, adaption and evaluation.
author:
- first_name: Barbara
full_name: Petritsch, Barbara
id: 406048EC-F248-11E8-B48F-1D18A9856A87
last_name: Petritsch
orcid: 0000-0003-2724-4614
- first_name: Jana
full_name: Porsche, Jana
id: 3252EDC2-F248-11E8-B48F-1D18A9856A87
last_name: Porsche
citation:
ama: 'Petritsch B, Porsche J. IST PubRep and IST DataRep: the institutional repositories
at IST Austria. VÖB Mitteilungen. 2018;71(1):199-206. doi:10.31263/voebm.v71i1.1993'
apa: 'Petritsch, B., & Porsche, J. (2018). IST PubRep and IST DataRep: the institutional
repositories at IST Austria. VÖB Mitteilungen. Vereinigung Österreichischer
Bibliothekarinnen und Bibliothekare. https://doi.org/10.31263/voebm.v71i1.1993'
chicago: 'Petritsch, Barbara, and Jana Porsche. “IST PubRep and IST DataRep: The
Institutional Repositories at IST Austria.” VÖB Mitteilungen. Vereinigung
Österreichischer Bibliothekarinnen und Bibliothekare, 2018. https://doi.org/10.31263/voebm.v71i1.1993.'
ieee: 'B. Petritsch and J. Porsche, “IST PubRep and IST DataRep: the institutional
repositories at IST Austria,” VÖB Mitteilungen, vol. 71, no. 1. Vereinigung
Österreichischer Bibliothekarinnen und Bibliothekare, pp. 199–206, 2018.'
ista: 'Petritsch B, Porsche J. 2018. IST PubRep and IST DataRep: the institutional
repositories at IST Austria. VÖB Mitteilungen. 71(1), 199–206.'
mla: 'Petritsch, Barbara, and Jana Porsche. “IST PubRep and IST DataRep: The Institutional
Repositories at IST Austria.” VÖB Mitteilungen, vol. 71, no. 1, Vereinigung
Österreichischer Bibliothekarinnen und Bibliothekare, 2018, pp. 199–206, doi:10.31263/voebm.v71i1.1993.'
short: B. Petritsch, J. Porsche, VÖB Mitteilungen 71 (2018) 199–206.
date_created: 2018-12-11T11:44:22Z
date_published: 2018-10-01T00:00:00Z
date_updated: 2021-01-12T08:01:26Z
day: '01'
ddc:
- '020'
department:
- _id: E-Lib
doi: 10.31263/voebm.v71i1.1993
file:
- access_level: open_access
checksum: 7ac61bade5f37db011ca435ebcf86797
content_type: application/pdf
creator: dernst
date_created: 2018-12-17T12:40:27Z
date_updated: 2020-07-14T12:46:38Z
file_id: '5702'
file_name: 2018_VOEB_Petritsch.pdf
file_size: 509434
relation: main_file
file_date_updated: 2020-07-14T12:46:38Z
has_accepted_license: '1'
intvolume: ' 71'
issue: '1'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
page: 199 - 206
publication: VÖB Mitteilungen
publication_status: published
publisher: Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare
publist_id: '8001'
scopus_import: 1
status: public
title: 'IST PubRep and IST DataRep: the institutional repositories at IST Austria'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 71
year: '2018'
...
---
_id: '530'
abstract:
- lang: eng
text: Inclusion–exclusion is an effective method for computing the volume of a union
of measurable sets. We extend it to multiple coverings, proving short inclusion–exclusion
formulas for the subset of Rn covered by at least k balls in a finite set. We
implement two of the formulas in dimension n=3 and report on results obtained
with our software.
article_processing_charge: No
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Mabel
full_name: Iglesias Ham, Mabel
id: 41B58C0C-F248-11E8-B48F-1D18A9856A87
last_name: Iglesias Ham
citation:
ama: 'Edelsbrunner H, Iglesias Ham M. Multiple covers with balls I: Inclusion–exclusion.
Computational Geometry: Theory and Applications. 2018;68:119-133. doi:10.1016/j.comgeo.2017.06.014'
apa: 'Edelsbrunner, H., & Iglesias Ham, M. (2018). Multiple covers with balls
I: Inclusion–exclusion. Computational Geometry: Theory and Applications.
Elsevier. https://doi.org/10.1016/j.comgeo.2017.06.014'
chicago: 'Edelsbrunner, Herbert, and Mabel Iglesias Ham. “Multiple Covers with Balls
I: Inclusion–Exclusion.” Computational Geometry: Theory and Applications.
Elsevier, 2018. https://doi.org/10.1016/j.comgeo.2017.06.014.'
ieee: 'H. Edelsbrunner and M. Iglesias Ham, “Multiple covers with balls I: Inclusion–exclusion,”
Computational Geometry: Theory and Applications, vol. 68. Elsevier, pp.
119–133, 2018.'
ista: 'Edelsbrunner H, Iglesias Ham M. 2018. Multiple covers with balls I: Inclusion–exclusion.
Computational Geometry: Theory and Applications. 68, 119–133.'
mla: 'Edelsbrunner, Herbert, and Mabel Iglesias Ham. “Multiple Covers with Balls
I: Inclusion–Exclusion.” Computational Geometry: Theory and Applications,
vol. 68, Elsevier, 2018, pp. 119–33, doi:10.1016/j.comgeo.2017.06.014.'
short: 'H. Edelsbrunner, M. Iglesias Ham, Computational Geometry: Theory and Applications
68 (2018) 119–133.'
date_created: 2018-12-11T11:46:59Z
date_published: 2018-03-01T00:00:00Z
date_updated: 2023-09-13T08:59:00Z
day: '01'
ddc:
- '000'
department:
- _id: HeEd
doi: 10.1016/j.comgeo.2017.06.014
ec_funded: 1
external_id:
isi:
- '000415778300010'
file:
- access_level: open_access
checksum: 1c8d58cd489a66cd3e2064c1141c8c5e
content_type: application/pdf
creator: dernst
date_created: 2019-02-12T06:47:52Z
date_updated: 2020-07-14T12:46:38Z
file_id: '5953'
file_name: 2018_Edelsbrunner.pdf
file_size: 708357
relation: main_file
file_date_updated: 2020-07-14T12:46:38Z
has_accepted_license: '1'
intvolume: ' 68'
isi: 1
language:
- iso: eng
month: '03'
oa: 1
oa_version: Preprint
page: 119 - 133
project:
- _id: 255D761E-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '318493'
name: Topological Complex Systems
publication: 'Computational Geometry: Theory and Applications'
publication_status: published
publisher: Elsevier
publist_id: '7289'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Multiple covers with balls I: Inclusion–exclusion'
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 68
year: '2018'
...
---
_id: '536'
abstract:
- lang: eng
text: 'We consider the problem of consensus in the challenging classic model. In
this model, the adversary is adaptive; it can choose which processors crash at
any point during the course of the algorithm. Further, communication is via asynchronous
message passing: there is no known upper bound on the time to send a message from
one processor to another, and all messages and coin flips are seen by the adversary.
We describe a new randomized consensus protocol with expected message complexity
O(n2log2n) when fewer than n / 2 processes may fail by crashing. This is an almost-linear
improvement over the best previously known protocol, and within logarithmic factors
of a known Ω(n2) message lower bound. The protocol further ensures that no process
sends more than O(nlog3n) messages in expectation, which is again within logarithmic
factors of optimal. We also present a generalization of the algorithm to an arbitrary
number of failures t, which uses expected O(nt+t2log2t) total messages. Our approach
is to build a message-efficient, resilient mechanism for aggregating individual
processor votes, implementing the message-passing equivalent of a weak shared
coin. Roughly, in our protocol, a processor first announces its votes to small
groups, then propagates them to increasingly larger groups as it generates more
and more votes. To bound the number of messages that an individual process might
have to send or receive, the protocol progressively increases the weight of generated
votes. The main technical challenge is bounding the impact of votes that are still
“in flight” (generated, but not fully propagated) on the final outcome of the
shared coin, especially since such votes might have different weights. We achieve
this by leveraging the structure of the algorithm, and a technical argument based
on martingale concentration bounds. Overall, we show that it is possible to build
an efficient message-passing implementation of a shared coin, and in the process
(almost-optimally) solve the classic consensus problem in the asynchronous message-passing
model.'
article_processing_charge: Yes (via OA deal)
author:
- first_name: Dan-Adrian
full_name: Alistarh, Dan-Adrian
id: 4A899BFC-F248-11E8-B48F-1D18A9856A87
last_name: Alistarh
orcid: 0000-0003-3650-940X
- first_name: James
full_name: Aspnes, James
last_name: Aspnes
- first_name: Valerie
full_name: King, Valerie
last_name: King
- first_name: Jared
full_name: Saia, Jared
last_name: Saia
citation:
ama: Alistarh D-A, Aspnes J, King V, Saia J. Communication-efficient randomized
consensus. Distributed Computing. 2018;31(6):489-501. doi:10.1007/s00446-017-0315-1
apa: Alistarh, D.-A., Aspnes, J., King, V., & Saia, J. (2018). Communication-efficient
randomized consensus. Distributed Computing. Springer. https://doi.org/10.1007/s00446-017-0315-1
chicago: Alistarh, Dan-Adrian, James Aspnes, Valerie King, and Jared Saia. “Communication-Efficient
Randomized Consensus.” Distributed Computing. Springer, 2018. https://doi.org/10.1007/s00446-017-0315-1.
ieee: D.-A. Alistarh, J. Aspnes, V. King, and J. Saia, “Communication-efficient
randomized consensus,” Distributed Computing, vol. 31, no. 6. Springer,
pp. 489–501, 2018.
ista: Alistarh D-A, Aspnes J, King V, Saia J. 2018. Communication-efficient randomized
consensus. Distributed Computing. 31(6), 489–501.
mla: Alistarh, Dan-Adrian, et al. “Communication-Efficient Randomized Consensus.”
Distributed Computing, vol. 31, no. 6, Springer, 2018, pp. 489–501, doi:10.1007/s00446-017-0315-1.
short: D.-A. Alistarh, J. Aspnes, V. King, J. Saia, Distributed Computing 31 (2018)
489–501.
date_created: 2018-12-11T11:47:01Z
date_published: 2018-11-01T00:00:00Z
date_updated: 2023-02-23T12:23:25Z
day: '01'
ddc:
- '000'
department:
- _id: DaAl
doi: 10.1007/s00446-017-0315-1
file:
- access_level: open_access
checksum: 69b46e537acdcac745237ddb853fcbb5
content_type: application/pdf
creator: dernst
date_created: 2019-01-22T07:25:51Z
date_updated: 2020-07-14T12:46:38Z
file_id: '5867'
file_name: 2017_DistribComp_Alistarh.pdf
file_size: 595707
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file_date_updated: 2020-07-14T12:46:38Z
has_accepted_license: '1'
intvolume: ' 31'
issue: '6'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
page: 489-501
project:
- _id: B67AFEDC-15C9-11EA-A837-991A96BB2854
name: IST Austria Open Access Fund
publication: Distributed Computing
publication_identifier:
issn:
- '01782770'
publication_status: published
publisher: Springer
publist_id: '7281'
quality_controlled: '1'
scopus_import: 1
status: public
title: Communication-efficient randomized consensus
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 31
year: '2018'
...
---
_id: '21'
abstract:
- lang: eng
text: Parvalbumin-positive (PV+) GABAergic interneurons in hippocampal microcircuits
are thought to play a key role in several higher network functions, such as feedforward
and feedback inhibition, network oscillations, and pattern separation. Fast lateral
inhibition mediated by GABAergic interneurons may implement a winner-takes-all
mechanism in the hippocampal input layer. However, it is not clear whether the
functional connectivity rules of granule cells (GCs) and interneurons in the dentate
gyrus are consistent with such a mechanism. Using simultaneous patch-clamp recordings
from up to seven GCs and up to four PV+ interneurons in the dentate gyrus, we
find that connectivity is structured in space, synapse-specific, and enriched
in specific disynaptic motifs. In contrast to the neocortex, lateral inhibition
in the dentate gyrus (in which a GC inhibits neighboring GCs via a PV+ interneuron)
is ~ 10-times more abundant than recurrent inhibition (in which a GC inhibits
itself). Thus, unique connectivity rules may enable the dentate gyrus to perform
specific higher-order computations
acknowledgement: This project received funding from the European Research Council
(ERC) under the European Union’s Horizon 2020 research and innovation programme
(grant agreement No 692692) and the Fond zur Förderung der Wissenschaftlichen Forschung
(Z 312-B27, Wittgenstein award), both to P.J..
article_number: '4605'
article_processing_charge: No
article_type: original
author:
- first_name: 'Claudia '
full_name: 'Espinoza Martinez, Claudia '
id: 31FFEE2E-F248-11E8-B48F-1D18A9856A87
last_name: Espinoza Martinez
orcid: 0000-0003-4710-2082
- first_name: José
full_name: Guzmán, José
id: 30CC5506-F248-11E8-B48F-1D18A9856A87
last_name: Guzmán
orcid: 0000-0003-2209-5242
- first_name: Xiaomin
full_name: Zhang, Xiaomin
id: 423EC9C2-F248-11E8-B48F-1D18A9856A87
last_name: Zhang
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Espinoza Martinez C, Guzmán J, Zhang X, Jonas PM. Parvalbumin+ interneurons
obey unique connectivity rules and establish a powerful lateral-inhibition microcircuit
in dentate gyrus. Nature Communications. 2018;9(1). doi:10.1038/s41467-018-06899-3
apa: Espinoza Martinez, C., Guzmán, J., Zhang, X., & Jonas, P. M. (2018). Parvalbumin+
interneurons obey unique connectivity rules and establish a powerful lateral-inhibition
microcircuit in dentate gyrus. Nature Communications. Nature Publishing
Group. https://doi.org/10.1038/s41467-018-06899-3
chicago: Espinoza Martinez, Claudia , José Guzmán, Xiaomin Zhang, and Peter M Jonas.
“Parvalbumin+ Interneurons Obey Unique Connectivity Rules and Establish a Powerful
Lateral-Inhibition Microcircuit in Dentate Gyrus.” Nature Communications.
Nature Publishing Group, 2018. https://doi.org/10.1038/s41467-018-06899-3.
ieee: C. Espinoza Martinez, J. Guzmán, X. Zhang, and P. M. Jonas, “Parvalbumin+
interneurons obey unique connectivity rules and establish a powerful lateral-inhibition
microcircuit in dentate gyrus,” Nature Communications, vol. 9, no. 1. Nature
Publishing Group, 2018.
ista: Espinoza Martinez C, Guzmán J, Zhang X, Jonas PM. 2018. Parvalbumin+ interneurons
obey unique connectivity rules and establish a powerful lateral-inhibition microcircuit
in dentate gyrus. Nature Communications. 9(1), 4605.
mla: Espinoza Martinez, Claudia, et al. “Parvalbumin+ Interneurons Obey Unique Connectivity
Rules and Establish a Powerful Lateral-Inhibition Microcircuit in Dentate Gyrus.”
Nature Communications, vol. 9, no. 1, 4605, Nature Publishing Group, 2018,
doi:10.1038/s41467-018-06899-3.
short: C. Espinoza Martinez, J. Guzmán, X. Zhang, P.M. Jonas, Nature Communications
9 (2018).
date_created: 2018-12-11T11:44:12Z
date_published: 2018-11-02T00:00:00Z
date_updated: 2024-03-25T23:30:16Z
day: '02'
ddc:
- '570'
department:
- _id: PeJo
doi: 10.1038/s41467-018-06899-3
ec_funded: 1
external_id:
isi:
- '000449069700009'
file:
- access_level: open_access
checksum: 9fe2a63bd95a5067d896c087d07998f3
content_type: application/pdf
creator: dernst
date_created: 2018-12-17T15:41:57Z
date_updated: 2020-07-14T12:45:28Z
file_id: '5715'
file_name: 2018_NatureComm_Espinoza.pdf
file_size: 4651930
relation: main_file
file_date_updated: 2020-07-14T12:45:28Z
has_accepted_license: '1'
intvolume: ' 9'
isi: 1
issue: '1'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
project:
- _id: 25B7EB9E-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '692692'
name: Biophysics and circuit function of a giant cortical glumatergic synapse
- _id: 25C5A090-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z00312
name: The Wittgenstein Prize
publication: Nature Communications
publication_status: published
publisher: Nature Publishing Group
publist_id: '8034'
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/lateral-inhibition-keeps-similar-memories-apart/
record:
- id: '6363'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Parvalbumin+ interneurons obey unique connectivity rules and establish a powerful
lateral-inhibition microcircuit in dentate gyrus
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 9
year: '2018'
...
---
_id: '22'
abstract:
- lang: eng
text: Conventional ultra-high sensitivity detectors in the millimeter-wave range
are usually cooled as their own thermal noise at room temperature would mask the
weak received radiation. The need for cryogenic systems increases the cost and
complexity of the instruments, hindering the development of, among others, airborne
and space applications. In this work, the nonlinear parametric upconversion of
millimeter-wave radiation to the optical domain inside high-quality (Q) lithium
niobate whispering-gallery mode (WGM) resonators is proposed for ultra-low noise
detection. We experimentally demonstrate coherent upconversion of millimeter-wave
signals to a 1550 nm telecom carrier, with a photon conversion efficiency surpassing
the state-of-the-art by 2 orders of magnitude. Moreover, a theoretical model shows
that the thermal equilibrium of counterpropagating WGMs is broken by overcoupling
the millimeter-wave WGM, effectively cooling the upconverted mode and allowing
ultra-low noise detection. By theoretically estimating the sensitivity of a correlation
radiometer based on the presented scheme, it is found that room-temperature radiometers
with better sensitivity than state-of-the-art high-electron-mobility transistor
(HEMT)-based radiometers can be designed. This detection paradigm can be used
to develop room-temperature instrumentation for radio astronomy, earth observation,
planetary missions, and imaging systems.
article_processing_charge: No
article_type: original
author:
- first_name: Gabriel
full_name: Botello, Gabriel
last_name: Botello
- first_name: Florian
full_name: Sedlmeir, Florian
last_name: Sedlmeir
- first_name: Alfredo R
full_name: Rueda Sanchez, Alfredo R
id: 3B82B0F8-F248-11E8-B48F-1D18A9856A87
last_name: Rueda Sanchez
orcid: 0000-0001-6249-5860
- first_name: Kerlos
full_name: Abdalmalak, Kerlos
last_name: Abdalmalak
- first_name: Elliott
full_name: Brown, Elliott
last_name: Brown
- first_name: Gerd
full_name: Leuchs, Gerd
last_name: Leuchs
- first_name: Sascha
full_name: Preu, Sascha
last_name: Preu
- first_name: Daniel
full_name: Segovia Vargas, Daniel
last_name: Segovia Vargas
- first_name: Dmitry
full_name: Strekalov, Dmitry
last_name: Strekalov
- first_name: Luis
full_name: Munoz, Luis
last_name: Munoz
- first_name: Harald
full_name: Schwefel, Harald
last_name: Schwefel
citation:
ama: Botello G, Sedlmeir F, Rueda Sanchez AR, et al. Sensitivity limits of millimeter-wave
photonic radiometers based on efficient electro-optic upconverters. Optica.
2018;5(10):1210-1219. doi:10.1364/OPTICA.5.001210
apa: Botello, G., Sedlmeir, F., Rueda Sanchez, A. R., Abdalmalak, K., Brown, E.,
Leuchs, G., … Schwefel, H. (2018). Sensitivity limits of millimeter-wave photonic
radiometers based on efficient electro-optic upconverters. Optica. https://doi.org/10.1364/OPTICA.5.001210
chicago: Botello, Gabriel, Florian Sedlmeir, Alfredo R Rueda Sanchez, Kerlos Abdalmalak,
Elliott Brown, Gerd Leuchs, Sascha Preu, et al. “Sensitivity Limits of Millimeter-Wave
Photonic Radiometers Based on Efficient Electro-Optic Upconverters.” Optica,
2018. https://doi.org/10.1364/OPTICA.5.001210.
ieee: G. Botello et al., “Sensitivity limits of millimeter-wave photonic
radiometers based on efficient electro-optic upconverters,” Optica, vol.
5, no. 10. pp. 1210–1219, 2018.
ista: Botello G, Sedlmeir F, Rueda Sanchez AR, Abdalmalak K, Brown E, Leuchs G,
Preu S, Segovia Vargas D, Strekalov D, Munoz L, Schwefel H. 2018. Sensitivity
limits of millimeter-wave photonic radiometers based on efficient electro-optic
upconverters. Optica. 5(10), 1210–1219.
mla: Botello, Gabriel, et al. “Sensitivity Limits of Millimeter-Wave Photonic Radiometers
Based on Efficient Electro-Optic Upconverters.” Optica, vol. 5, no. 10,
2018, pp. 1210–19, doi:10.1364/OPTICA.5.001210.
short: G. Botello, F. Sedlmeir, A.R. Rueda Sanchez, K. Abdalmalak, E. Brown, G.
Leuchs, S. Preu, D. Segovia Vargas, D. Strekalov, L. Munoz, H. Schwefel, Optica
5 (2018) 1210–1219.
date_created: 2018-12-11T11:44:12Z
date_published: 2018-10-20T00:00:00Z
date_updated: 2023-10-17T12:12:40Z
day: '20'
department:
- _id: JoFi
doi: 10.1364/OPTICA.5.001210
external_id:
isi:
- '000447853100007'
intvolume: ' 5'
isi: 1
issue: '10'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: 'www.doi.org/10.1364/OPTICA.5.001210 '
month: '10'
oa: 1
oa_version: Published Version
page: 1210 - 1219
publication: Optica
publication_identifier:
issn:
- '23342536'
publication_status: published
publist_id: '8033'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Sensitivity limits of millimeter-wave photonic radiometers based on efficient
electro-optic upconverters
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5
year: '2018'
...
---
_id: '23'
abstract:
- lang: eng
text: The strong atomistic spin–orbit coupling of holes makes single-shot spin readout
measurements difficult because it reduces the spin lifetimes. By integrating the
charge sensor into a high bandwidth radio frequency reflectometry setup, we were
able to demonstrate single-shot readout of a germanium quantum dot hole spin and
measure the spin lifetime. Hole spin relaxation times of about 90 μs at 500 mT
are reported, with a total readout visibility of about 70%. By analyzing separately
the spin-to-charge conversion and charge readout fidelities, we have obtained
insight into the processes limiting the visibilities of hole spins. The analyses
suggest that high hole visibilities are feasible at realistic experimental conditions,
underlying the potential of hole spins for the realization of viable qubit devices.
acknowledged_ssus:
- _id: M-Shop
- _id: NanoFab
article_processing_charge: No
author:
- first_name: Lada
full_name: Vukušić, Lada
id: 31E9F056-F248-11E8-B48F-1D18A9856A87
last_name: Vukušić
orcid: 0000-0003-2424-8636
- first_name: Josip
full_name: Kukucka, Josip
id: 3F5D8856-F248-11E8-B48F-1D18A9856A87
last_name: Kukucka
- first_name: Hannes
full_name: Watzinger, Hannes
id: 35DF8E50-F248-11E8-B48F-1D18A9856A87
last_name: Watzinger
- first_name: Joshua M
full_name: Milem, Joshua M
id: 4CDE0A96-F248-11E8-B48F-1D18A9856A87
last_name: Milem
- first_name: Friedrich
full_name: Schäffler, Friedrich
last_name: Schäffler
- first_name: Georgios
full_name: Katsaros, Georgios
id: 38DB5788-F248-11E8-B48F-1D18A9856A87
last_name: Katsaros
orcid: 0000-0001-8342-202X
citation:
ama: Vukušić L, Kukucka J, Watzinger H, Milem JM, Schäffler F, Katsaros G. Single-shot
readout of hole spins in Ge. Nano Letters. 2018;18(11):7141-7145. doi:10.1021/acs.nanolett.8b03217
apa: Vukušić, L., Kukucka, J., Watzinger, H., Milem, J. M., Schäffler, F., &
Katsaros, G. (2018). Single-shot readout of hole spins in Ge. Nano Letters.
American Chemical Society. https://doi.org/10.1021/acs.nanolett.8b03217
chicago: Vukušić, Lada, Josip Kukucka, Hannes Watzinger, Joshua M Milem, Friedrich
Schäffler, and Georgios Katsaros. “Single-Shot Readout of Hole Spins in Ge.” Nano
Letters. American Chemical Society, 2018. https://doi.org/10.1021/acs.nanolett.8b03217.
ieee: L. Vukušić, J. Kukucka, H. Watzinger, J. M. Milem, F. Schäffler, and G. Katsaros,
“Single-shot readout of hole spins in Ge,” Nano Letters, vol. 18, no. 11.
American Chemical Society, pp. 7141–7145, 2018.
ista: Vukušić L, Kukucka J, Watzinger H, Milem JM, Schäffler F, Katsaros G. 2018.
Single-shot readout of hole spins in Ge. Nano Letters. 18(11), 7141–7145.
mla: Vukušić, Lada, et al. “Single-Shot Readout of Hole Spins in Ge.” Nano Letters,
vol. 18, no. 11, American Chemical Society, 2018, pp. 7141–45, doi:10.1021/acs.nanolett.8b03217.
short: L. Vukušić, J. Kukucka, H. Watzinger, J.M. Milem, F. Schäffler, G. Katsaros,
Nano Letters 18 (2018) 7141–7145.
date_created: 2018-12-11T11:44:13Z
date_published: 2018-10-25T00:00:00Z
date_updated: 2023-09-18T09:30:37Z
day: '25'
ddc:
- '530'
department:
- _id: GeKa
doi: 10.1021/acs.nanolett.8b03217
ec_funded: 1
external_id:
isi:
- '000451102100064'
pmid:
- '30359041'
file:
- access_level: open_access
checksum: 3e6034a94c6b5335e939145d88bdb371
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:16:08Z
date_updated: 2020-07-14T12:45:37Z
file_id: '5194'
file_name: IST-2018-1065-v1+1_ACS_nanoletters_8b03217.pdf
file_size: 1361441
relation: main_file
file_date_updated: 2020-07-14T12:45:37Z
has_accepted_license: '1'
intvolume: ' 18'
isi: 1
issue: '11'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
page: 7141 - 7145
pmid: 1
project:
- _id: 25517E86-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '335497'
name: Towards Spin qubits and Majorana fermions in Germanium selfassembled hut-wires
publication: Nano Letters
publication_identifier:
issn:
- '15306984'
publication_status: published
publisher: American Chemical Society
publist_id: '8032'
pubrep_id: '1065'
quality_controlled: '1'
related_material:
record:
- id: '7977'
relation: popular_science
- id: '69'
relation: dissertation_contains
status: public
- id: '7996'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Single-shot readout of hole spins in Ge
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 18
year: '2018'
...
---
_id: '24'
abstract:
- lang: eng
text: Partially-observable Markov decision processes (POMDPs) with discounted-sum
payoff are a standard framework to model a wide range of problems related to decision
making under uncertainty. Traditionally, the goal has been to obtain policies
that optimize the expectation of the discounted-sum payoff. A key drawback of
the expectation measure is that even low probability events with extreme payoff
can significantly affect the expectation, and thus the obtained policies are not
necessarily risk-averse. An alternate approach is to optimize the probability
that the payoff is above a certain threshold, which allows obtaining risk-averse
policies, but ignores optimization of the expectation. We consider the expectation
optimization with probabilistic guarantee (EOPG) problem, where the goal is to
optimize the expectation ensuring that the payoff is above a given threshold with
at least a specified probability. We present several results on the EOPG problem,
including the first algorithm to solve it.
acknowledgement: "This research was supported by the Vienna Science and Technology
Fund (WWTF) grant ICT15-003; Austrian Science Fund (FWF): S11407-N23(RiSE/SHiNE);and
an ERC Start Grant (279307:Graph Games).\r\n"
article_processing_charge: No
arxiv: 1
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Adrian
full_name: Elgyütt, Adrian
id: 4A2E9DBA-F248-11E8-B48F-1D18A9856A87
last_name: Elgyütt
- first_name: Petr
full_name: Novotny, Petr
id: 3CC3B868-F248-11E8-B48F-1D18A9856A87
last_name: Novotny
- first_name: Owen
full_name: Rouillé, Owen
last_name: Rouillé
citation:
ama: 'Chatterjee K, Elgyütt A, Novotný P, Rouillé O. Expectation optimization with
probabilistic guarantees in POMDPs with discounted-sum objectives. In: Vol 2018.
IJCAI; 2018:4692-4699. doi:10.24963/ijcai.2018/652'
apa: 'Chatterjee, K., Elgyütt, A., Novotný, P., & Rouillé, O. (2018). Expectation
optimization with probabilistic guarantees in POMDPs with discounted-sum objectives
(Vol. 2018, pp. 4692–4699). Presented at the IJCAI: International Joint Conference
on Artificial Intelligence, Stockholm, Sweden: IJCAI. https://doi.org/10.24963/ijcai.2018/652'
chicago: Chatterjee, Krishnendu, Adrian Elgyütt, Petr Novotný, and Owen Rouillé.
“Expectation Optimization with Probabilistic Guarantees in POMDPs with Discounted-Sum
Objectives,” 2018:4692–99. IJCAI, 2018. https://doi.org/10.24963/ijcai.2018/652.
ieee: 'K. Chatterjee, A. Elgyütt, P. Novotný, and O. Rouillé, “Expectation optimization
with probabilistic guarantees in POMDPs with discounted-sum objectives,” presented
at the IJCAI: International Joint Conference on Artificial Intelligence, Stockholm,
Sweden, 2018, vol. 2018, pp. 4692–4699.'
ista: 'Chatterjee K, Elgyütt A, Novotný P, Rouillé O. 2018. Expectation optimization
with probabilistic guarantees in POMDPs with discounted-sum objectives. IJCAI:
International Joint Conference on Artificial Intelligence vol. 2018, 4692–4699.'
mla: Chatterjee, Krishnendu, et al. Expectation Optimization with Probabilistic
Guarantees in POMDPs with Discounted-Sum Objectives. Vol. 2018, IJCAI, 2018,
pp. 4692–99, doi:10.24963/ijcai.2018/652.
short: K. Chatterjee, A. Elgyütt, P. Novotný, O. Rouillé, in:, IJCAI, 2018, pp.
4692–4699.
conference:
end_date: 2018-07-19
location: Stockholm, Sweden
name: 'IJCAI: International Joint Conference on Artificial Intelligence'
start_date: 2018-07-13
date_created: 2018-12-11T11:44:13Z
date_published: 2018-07-01T00:00:00Z
date_updated: 2025-06-02T08:53:48Z
day: '01'
department:
- _id: KrCh
- _id: ToHe
doi: 10.24963/ijcai.2018/652
ec_funded: 1
external_id:
arxiv:
- '1804.10601'
isi:
- '000764175404117'
intvolume: ' 2018'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1804.10601
month: '07'
oa: 1
oa_version: Preprint
page: 4692 - 4699
project:
- _id: 25892FC0-B435-11E9-9278-68D0E5697425
grant_number: ICT15-003
name: Efficient Algorithms for Computer Aided Verification
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
publication_status: published
publisher: IJCAI
publist_id: '8031'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Expectation optimization with probabilistic guarantees in POMDPs with discounted-sum
objectives
type: conference
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 2018
year: '2018'
...
---
_id: '25'
abstract:
- lang: eng
text: 'Partially observable Markov decision processes (POMDPs) are the standard
models for planning under uncertainty with both finite and infinite horizon. Besides
the well-known discounted-sum objective, indefinite-horizon objective (aka Goal-POMDPs)
is another classical objective for POMDPs. In this case, given a set of target
states and a positive cost for each transition, the optimization objective is
to minimize the expected total cost until a target state is reached. In the literature,
RTDP-Bel or heuristic search value iteration (HSVI) have been used for solving
Goal-POMDPs. Neither of these algorithms has theoretical convergence guarantees,
and HSVI may even fail to terminate its trials. We give the following contributions:
(1) We discuss the challenges introduced in Goal-POMDPs and illustrate how they
prevent the original HSVI from converging. (2) We present a novel algorithm inspired
by HSVI, termed Goal-HSVI, and show that our algorithm has convergence guarantees.
(3) We show that Goal-HSVI outperforms RTDP-Bel on a set of well-known examples.'
acknowledgement: '∗This work has been supported by Vienna Science and Technology Fund
(WWTF) Project ICT15-003, Austrian Science Fund (FWF) NFN Grant No S11407-N23 (RiSE/SHiNE),
and ERC Starting grant (279307: Graph Games). This research was sponsored by the
Army Research Laboratory and was accomplished under Cooperative Agreement Number
W911NF-13-2-0045 (ARL Cyber Security CRA). '
article_processing_charge: No
author:
- first_name: Karel
full_name: Horák, Karel
last_name: Horák
- first_name: Branislav
full_name: Bošanský, Branislav
last_name: Bošanský
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
citation:
ama: 'Horák K, Bošanský B, Chatterjee K. Goal-HSVI: Heuristic search value iteration
for goal-POMDPs. In: Proceedings of the Twenty-Seventh International Joint
Conference on Artificial Intelligence. Vol 2018-July. IJCAI; 2018:4764-4770.
doi:10.24963/ijcai.2018/662'
apa: 'Horák, K., Bošanský, B., & Chatterjee, K. (2018). Goal-HSVI: Heuristic
search value iteration for goal-POMDPs. In Proceedings of the Twenty-Seventh
International Joint Conference on Artificial Intelligence (Vol. 2018–July,
pp. 4764–4770). Stockholm, Sweden: IJCAI. https://doi.org/10.24963/ijcai.2018/662'
chicago: 'Horák, Karel, Branislav Bošanský, and Krishnendu Chatterjee. “Goal-HSVI:
Heuristic Search Value Iteration for Goal-POMDPs.” In Proceedings of the Twenty-Seventh
International Joint Conference on Artificial Intelligence, 2018–July:4764–70.
IJCAI, 2018. https://doi.org/10.24963/ijcai.2018/662.'
ieee: 'K. Horák, B. Bošanský, and K. Chatterjee, “Goal-HSVI: Heuristic search value
iteration for goal-POMDPs,” in Proceedings of the Twenty-Seventh International
Joint Conference on Artificial Intelligence, Stockholm, Sweden, 2018, vol.
2018–July, pp. 4764–4770.'
ista: 'Horák K, Bošanský B, Chatterjee K. 2018. Goal-HSVI: Heuristic search value
iteration for goal-POMDPs. Proceedings of the Twenty-Seventh International Joint
Conference on Artificial Intelligence. IJCAI: International Joint Conference on
Artificial Intelligence vol. 2018–July, 4764–4770.'
mla: 'Horák, Karel, et al. “Goal-HSVI: Heuristic Search Value Iteration for Goal-POMDPs.”
Proceedings of the Twenty-Seventh International Joint Conference on Artificial
Intelligence, vol. 2018–July, IJCAI, 2018, pp. 4764–70, doi:10.24963/ijcai.2018/662.'
short: K. Horák, B. Bošanský, K. Chatterjee, in:, Proceedings of the Twenty-Seventh
International Joint Conference on Artificial Intelligence, IJCAI, 2018, pp. 4764–4770.
conference:
end_date: 2018-07-19
location: Stockholm, Sweden
name: 'IJCAI: International Joint Conference on Artificial Intelligence'
start_date: 2018-07-13
date_created: 2018-12-11T11:44:13Z
date_published: 2018-07-01T00:00:00Z
date_updated: 2025-06-02T08:53:40Z
day: '01'
department:
- _id: KrCh
doi: 10.24963/ijcai.2018/662
ec_funded: 1
external_id:
isi:
- '000764175404127'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.24963/ijcai.2018/662
month: '07'
oa: 1
oa_version: Published Version
page: 4764 - 4770
project:
- _id: 25892FC0-B435-11E9-9278-68D0E5697425
grant_number: ICT15-003
name: Efficient Algorithms for Computer Aided Verification
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
publication: Proceedings of the Twenty-Seventh International Joint Conference on Artificial
Intelligence
publication_status: published
publisher: IJCAI
publist_id: '8030'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Goal-HSVI: Heuristic search value iteration for goal-POMDPs'
type: conference
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 2018-July
year: '2018'
...
---
_id: '26'
abstract:
- lang: eng
text: Expression of genes is a fundamental molecular phenotype that is subject to
evolution by different types of mutations. Both the rate and the effect of mutations
may depend on the DNA sequence context of a particular gene or a particular promoter
sequence. In this thesis I investigate the nature of this dependence using simple
genetic systems in Escherichia coli. With these systems I explore the evolution
of constitutive gene expression from random starting sequences at different loci
on the chromosome and at different locations in sequence space. First, I dissect
chromosomal neighborhood effects that underlie locus-dependent differences in
the potential of a gene under selection to become more highly expressed. Next,
I find that the effects of point mutations in promoter sequences are dependent
on sequence context, and that an existing energy matrix model performs poorly
in predicting relative expression of unrelated sequences. Finally, I show that
a substantial fraction of random sequences contain functional promoters and I
present an extended thermodynamic model that predicts promoter strength in full
sequence space. Taken together, these results provide new insights and guides
on how to integrate information on sequence context to improve our qualitative
and quantitative understanding of bacterial gene expression, with implications
for rapid evolution of drug resistance, de novo evolution of genes, and horizontal
gene transfer.
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Magdalena
full_name: Steinrück, Magdalena
id: 2C023F40-F248-11E8-B48F-1D18A9856A87
last_name: Steinrück
orcid: 0000-0003-1229-9719
citation:
ama: Steinrück M. The influence of sequence context on the evolution of bacterial
gene expression. 2018. doi:10.15479/AT:ISTA:th1059
apa: Steinrück, M. (2018). The influence of sequence context on the evolution
of bacterial gene expression. Institute of Science and Technology Austria.
https://doi.org/10.15479/AT:ISTA:th1059
chicago: Steinrück, Magdalena. “The Influence of Sequence Context on the Evolution
of Bacterial Gene Expression.” Institute of Science and Technology Austria, 2018.
https://doi.org/10.15479/AT:ISTA:th1059.
ieee: M. Steinrück, “The influence of sequence context on the evolution of bacterial
gene expression,” Institute of Science and Technology Austria, 2018.
ista: Steinrück M. 2018. The influence of sequence context on the evolution of bacterial
gene expression. Institute of Science and Technology Austria.
mla: Steinrück, Magdalena. The Influence of Sequence Context on the Evolution
of Bacterial Gene Expression. Institute of Science and Technology Austria,
2018, doi:10.15479/AT:ISTA:th1059.
short: M. Steinrück, The Influence of Sequence Context on the Evolution of Bacterial
Gene Expression, Institute of Science and Technology Austria, 2018.
date_created: 2018-12-11T11:44:14Z
date_published: 2018-10-30T00:00:00Z
date_updated: 2023-09-07T12:48:43Z
day: '30'
ddc:
- '576'
- '579'
degree_awarded: PhD
department:
- _id: CaGu
doi: 10.15479/AT:ISTA:th1059
file:
- access_level: closed
checksum: 413cbce1cd1debeae3abe2a25dbc70d1
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: dernst
date_created: 2019-02-08T10:51:22Z
date_updated: 2020-07-14T12:45:43Z
embargo_to: open_access
file_id: '5941'
file_name: Thesis_Steinrueck_final.docx
file_size: 9190845
relation: source_file
- access_level: open_access
checksum: 3def8b7854c8b42d643597ce0215efac
content_type: application/pdf
creator: dernst
date_created: 2019-02-08T10:51:22Z
date_updated: 2021-02-11T11:17:14Z
embargo: 2019-11-02
file_id: '5942'
file_name: Thesis_Steinrueck_final.pdf
file_size: 7521973
relation: main_file
file_date_updated: 2021-02-11T11:17:14Z
has_accepted_license: '1'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
page: '109'
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
publist_id: '8029'
pubrep_id: '1059'
related_material:
record:
- id: '704'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Calin C
full_name: Guet, Calin C
id: 47F8433E-F248-11E8-B48F-1D18A9856A87
last_name: Guet
orcid: 0000-0001-6220-2052
title: The influence of sequence context on the evolution of bacterial gene expression
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2018'
...
---
_id: '273'
abstract:
- lang: eng
text: The accuracy of information retrieval systems is often measured using complex
loss functions such as the average precision (AP) or the normalized discounted
cumulative gain (NDCG). Given a set of positive and negative samples, the parameters
of a retrieval system can be estimated by minimizing these loss functions. However,
the non-differentiability and non-decomposability of these loss functions does
not allow for simple gradient based optimization algorithms. This issue is generally
circumvented by either optimizing a structured hinge-loss upper bound to the loss
function or by using asymptotic methods like the direct-loss minimization framework.
Yet, the high computational complexity of loss-augmented inference, which is necessary
for both the frameworks, prohibits its use in large training data sets. To alleviate
this deficiency, we present a novel quicksort flavored algorithm for a large class
of non-decomposable loss functions. We provide a complete characterization of
the loss functions that are amenable to our algorithm, and show that it includes
both AP and NDCG based loss functions. Furthermore, we prove that no comparison
based algorithm can improve upon the computational complexity of our approach
asymptotically. We demonstrate the effectiveness of our approach in the context
of optimizing the structured hinge loss upper bound of AP and NDCG loss for learning
models for a variety of vision tasks. We show that our approach provides significantly
better results than simpler decomposable loss functions, while requiring a comparable
training time.
article_processing_charge: No
arxiv: 1
author:
- first_name: Pritish
full_name: Mohapatra, Pritish
last_name: Mohapatra
- first_name: Michal
full_name: Rolinek, Michal
id: 3CB3BC06-F248-11E8-B48F-1D18A9856A87
last_name: Rolinek
- first_name: C V
full_name: Jawahar, C V
last_name: Jawahar
- first_name: Vladimir
full_name: Kolmogorov, Vladimir
id: 3D50B0BA-F248-11E8-B48F-1D18A9856A87
last_name: Kolmogorov
- first_name: M Pawan
full_name: Kumar, M Pawan
last_name: Kumar
citation:
ama: 'Mohapatra P, Rolinek M, Jawahar CV, Kolmogorov V, Kumar MP. Efficient optimization
for rank-based loss functions. In: 2018 IEEE/CVF Conference on Computer Vision
and Pattern Recognition. IEEE; 2018:3693-3701. doi:10.1109/cvpr.2018.00389'
apa: 'Mohapatra, P., Rolinek, M., Jawahar, C. V., Kolmogorov, V., & Kumar, M.
P. (2018). Efficient optimization for rank-based loss functions. In 2018 IEEE/CVF
Conference on Computer Vision and Pattern Recognition (pp. 3693–3701). Salt
Lake City, UT, USA: IEEE. https://doi.org/10.1109/cvpr.2018.00389'
chicago: Mohapatra, Pritish, Michal Rolinek, C V Jawahar, Vladimir Kolmogorov, and
M Pawan Kumar. “Efficient Optimization for Rank-Based Loss Functions.” In 2018
IEEE/CVF Conference on Computer Vision and Pattern Recognition, 3693–3701.
IEEE, 2018. https://doi.org/10.1109/cvpr.2018.00389.
ieee: P. Mohapatra, M. Rolinek, C. V. Jawahar, V. Kolmogorov, and M. P. Kumar, “Efficient
optimization for rank-based loss functions,” in 2018 IEEE/CVF Conference on
Computer Vision and Pattern Recognition, Salt Lake City, UT, USA, 2018, pp.
3693–3701.
ista: 'Mohapatra P, Rolinek M, Jawahar CV, Kolmogorov V, Kumar MP. 2018. Efficient
optimization for rank-based loss functions. 2018 IEEE/CVF Conference on Computer
Vision and Pattern Recognition. CVPR: Conference on Computer Vision and Pattern
Recognition, 3693–3701.'
mla: Mohapatra, Pritish, et al. “Efficient Optimization for Rank-Based Loss Functions.”
2018 IEEE/CVF Conference on Computer Vision and Pattern Recognition, IEEE,
2018, pp. 3693–701, doi:10.1109/cvpr.2018.00389.
short: P. Mohapatra, M. Rolinek, C.V. Jawahar, V. Kolmogorov, M.P. Kumar, in:, 2018
IEEE/CVF Conference on Computer Vision and Pattern Recognition, IEEE, 2018, pp.
3693–3701.
conference:
end_date: 2018-06-22
location: Salt Lake City, UT, USA
name: 'CVPR: Conference on Computer Vision and Pattern Recognition'
start_date: 2018-06-18
date_created: 2018-12-11T11:45:33Z
date_published: 2018-06-28T00:00:00Z
date_updated: 2023-09-11T13:24:43Z
day: '28'
department:
- _id: VlKo
doi: 10.1109/cvpr.2018.00389
ec_funded: 1
external_id:
arxiv:
- '1604.08269'
isi:
- '000457843603087'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1604.08269
month: '06'
oa: 1
oa_version: Preprint
page: 3693-3701
project:
- _id: 25FBA906-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '616160'
name: 'Discrete Optimization in Computer Vision: Theory and Practice'
publication: 2018 IEEE/CVF Conference on Computer Vision and Pattern Recognition
publication_identifier:
isbn:
- '9781538664209'
publication_status: published
publisher: IEEE
quality_controlled: '1'
scopus_import: '1'
status: public
title: Efficient optimization for rank-based loss functions
type: conference
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2018'
...
---
_id: '275'
abstract:
- lang: eng
text: Lymphatic endothelial cells (LECs) release extracellular chemokines to guide
the migration of dendritic cells. In this study, we report that LECs also release
basolateral exosome-rich endothelial vesicles (EEVs) that are secreted in greater
numbers in the presence of inflammatory cytokines and accumulate in the perivascular
stroma of small lymphatic vessels in human chronic inflammatory diseases. Proteomic
analyses of EEV fractions identified > 1,700 cargo proteins and revealed a
dominant motility-promoting protein signature. In vitro and ex vivo EEV fractions
augmented cellular protrusion formation in a CX3CL1/fractalkine-dependent fashion
and enhanced the directional migratory response of human dendritic cells along
guidance cues. We conclude that perilymphatic LEC exosomes enhance exploratory
behavior and thus promote directional migration of CX3CR1-expressing cells in
complex tissue environments.
acknowledgement: M. Brown was supported by the Cell Communication in Health and Disease
Graduate Study Program of the Austrian Science Fund and Medizinische Universität
Wien, M. Sixt by the European Research Council (ERC GA 281556) and an Austrian Science
Fund START award, K.L. Bennett by the Austrian Academy of Sciences, D.G. Jackson
and L.A. Johnson by Unit Funding (MC_UU_12010/2) and project grants from the Medical
Research Council (G1100134 and MR/L008610/1), and M. Detmar by the Schweizerischer
Nationalfonds zur Förderung der Wissenschaftlichen Forschung and Advanced European
Research Council grant LYVICAM. K. Vaahtomeri was supported by an Academy of Finland
postdoctoral research grant (287853). This project has received funding from the
European Union’s Horizon 2020 research and innovation program under grant agreement
No. 668036 (RELENT).
article_processing_charge: No
author:
- first_name: Markus
full_name: Brown, Markus
id: 3DAB9AFC-F248-11E8-B48F-1D18A9856A87
last_name: Brown
- first_name: Louise
full_name: Johnson, Louise
last_name: Johnson
- first_name: Dario
full_name: Leone, Dario
last_name: Leone
- first_name: Peter
full_name: Májek, Peter
last_name: Májek
- first_name: Kari
full_name: Vaahtomeri, Kari
id: 368EE576-F248-11E8-B48F-1D18A9856A87
last_name: Vaahtomeri
orcid: 0000-0001-7829-3518
- first_name: Daniel
full_name: Senfter, Daniel
last_name: Senfter
- first_name: Nora
full_name: Bukosza, Nora
last_name: Bukosza
- first_name: Helga
full_name: Schachner, Helga
last_name: Schachner
- first_name: Gabriele
full_name: Asfour, Gabriele
last_name: Asfour
- first_name: Brigitte
full_name: Langer, Brigitte
last_name: Langer
- first_name: Robert
full_name: Hauschild, Robert
id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
last_name: Hauschild
orcid: 0000-0001-9843-3522
- first_name: Katja
full_name: Parapatics, Katja
last_name: Parapatics
- first_name: Young
full_name: Hong, Young
last_name: Hong
- first_name: Keiryn
full_name: Bennett, Keiryn
last_name: Bennett
- first_name: Renate
full_name: Kain, Renate
last_name: Kain
- first_name: Michael
full_name: Detmar, Michael
last_name: Detmar
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
- first_name: David
full_name: Jackson, David
last_name: Jackson
- first_name: Dontscho
full_name: Kerjaschki, Dontscho
last_name: Kerjaschki
citation:
ama: Brown M, Johnson L, Leone D, et al. Lymphatic exosomes promote dendritic cell
migration along guidance cues. Journal of Cell Biology. 2018;217(6):2205-2221.
doi:10.1083/jcb.201612051
apa: Brown, M., Johnson, L., Leone, D., Májek, P., Vaahtomeri, K., Senfter, D.,
… Kerjaschki, D. (2018). Lymphatic exosomes promote dendritic cell migration along
guidance cues. Journal of Cell Biology. Rockefeller University Press. https://doi.org/10.1083/jcb.201612051
chicago: Brown, Markus, Louise Johnson, Dario Leone, Peter Májek, Kari Vaahtomeri,
Daniel Senfter, Nora Bukosza, et al. “Lymphatic Exosomes Promote Dendritic Cell
Migration along Guidance Cues.” Journal of Cell Biology. Rockefeller University
Press, 2018. https://doi.org/10.1083/jcb.201612051.
ieee: M. Brown et al., “Lymphatic exosomes promote dendritic cell migration
along guidance cues,” Journal of Cell Biology, vol. 217, no. 6. Rockefeller
University Press, pp. 2205–2221, 2018.
ista: Brown M, Johnson L, Leone D, Májek P, Vaahtomeri K, Senfter D, Bukosza N,
Schachner H, Asfour G, Langer B, Hauschild R, Parapatics K, Hong Y, Bennett K,
Kain R, Detmar M, Sixt MK, Jackson D, Kerjaschki D. 2018. Lymphatic exosomes promote
dendritic cell migration along guidance cues. Journal of Cell Biology. 217(6),
2205–2221.
mla: Brown, Markus, et al. “Lymphatic Exosomes Promote Dendritic Cell Migration
along Guidance Cues.” Journal of Cell Biology, vol. 217, no. 6, Rockefeller
University Press, 2018, pp. 2205–21, doi:10.1083/jcb.201612051.
short: M. Brown, L. Johnson, D. Leone, P. Májek, K. Vaahtomeri, D. Senfter, N. Bukosza,
H. Schachner, G. Asfour, B. Langer, R. Hauschild, K. Parapatics, Y. Hong, K. Bennett,
R. Kain, M. Detmar, M.K. Sixt, D. Jackson, D. Kerjaschki, Journal of Cell Biology
217 (2018) 2205–2221.
date_created: 2018-12-11T11:45:33Z
date_published: 2018-04-12T00:00:00Z
date_updated: 2023-09-13T08:51:29Z
day: '12'
ddc:
- '570'
department:
- _id: MiSi
- _id: Bio
doi: 10.1083/jcb.201612051
ec_funded: 1
external_id:
isi:
- '000438077800026'
pmid:
- '29650776'
file:
- access_level: open_access
checksum: 9c7eba51a35c62da8c13f98120b64df4
content_type: application/pdf
creator: dernst
date_created: 2018-12-17T12:50:07Z
date_updated: 2020-07-14T12:45:45Z
file_id: '5704'
file_name: 2018_JournalCellBiology_Brown.pdf
file_size: 2252043
relation: main_file
file_date_updated: 2020-07-14T12:45:45Z
has_accepted_license: '1'
intvolume: ' 217'
isi: 1
issue: '6'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 2205 - 2221
pmid: 1
project:
- _id: 25A8E5EA-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Y 564-B12
name: Cytoskeletal force generation and transduction of leukocytes (FWF)
- _id: 25A603A2-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '281556'
name: Cytoskeletal force generation and force transduction of migrating leukocytes
(EU)
publication: Journal of Cell Biology
publication_status: published
publisher: Rockefeller University Press
publist_id: '7627'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Lymphatic exosomes promote dendritic cell migration along guidance cues
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 217
year: '2018'
...
---
_id: '276'
abstract:
- lang: eng
text: Directed migration of cells relies on their ability to sense directional guidance
cues and to interact with pericellular structures in order to transduce contractile
cytoskeletal- into mechanical forces. These biomechanical processes depend highly
on microenvironmental factors such as exposure to 2D surfaces or 3D matrices.
In vivo, the majority of cells are exposed to 3D environments. Data on 3D cell
migration are mostly derived from intravital microscopy or collagen-based in vitro
assays. Both approaches offer only limited controlla-bility of experimental conditions.
Here, we developed an automated microfluidic system that allows positioning of
cells in 3D microenvironments containing highly controlled diffusion-based chemokine
gradients. Tracking migration in such gradients was feasible in real time at the
single cell level. Moreover, the setup allowed on-chip immunocytochemistry and
thus linking of functional with phenotypical properties in individual cells. Spatially
defined retrieval of cells from the device allows down-stream off-chip analysis.
Using dendritic cells as a model, our setup specifically allowed us for the first
time to quantitate key migration characteristics of cells exposed to identical
gradients of the chemokine CCL19 yet placed on 2D vs in 3D environments. Migration
properties between 2D and 3D migration were distinct. Morphological features of
cells migrating in an in vitro 3D environment were similar to those of cells migrating
in animal tissues, but different from cells migrating on a surface. Our system
thus offers a highly controllable in vitro-mimic of a 3D environment that cells
traffic in vivo.
acknowledgement: This work was supported by the Swiss National Science Foundation
(MD-PhD fellowships, 323530_164221 to C.F.; and 323630_151483 to A.J.; grant PZ00P3_144863
to M.R, grant 31003A_156431 to T.S.; PZ00P3_148000 to C.T.B.; PZ00P3_154733 to M.M.),
a Novartis “FreeNovation” grant to M.M. and T.S. and an EMBO long-term fellowship
(ALTF 1396-2014) co-funded by the European Commission (LTFCOFUND2013, GA-2013-609409)
to J.R.. M.R. was supported by the Gebert Rüf Foundation (GRS 058/14). The funders
had no role in study design, data collection and analysis, decision to publish,
or preparation of the manuscript.
article_number: e0198330
article_processing_charge: No
article_type: original
author:
- first_name: Corina
full_name: Frick, Corina
last_name: Frick
- first_name: Philip
full_name: Dettinger, Philip
last_name: Dettinger
- first_name: Jörg
full_name: Renkawitz, Jörg
id: 3F0587C8-F248-11E8-B48F-1D18A9856A87
last_name: Renkawitz
orcid: 0000-0003-2856-3369
- first_name: Annaïse
full_name: Jauch, Annaïse
last_name: Jauch
- first_name: Christoph
full_name: Berger, Christoph
last_name: Berger
- first_name: Mike
full_name: Recher, Mike
last_name: Recher
- first_name: Timm
full_name: Schroeder, Timm
last_name: Schroeder
- first_name: Matthias
full_name: Mehling, Matthias
last_name: Mehling
citation:
ama: Frick C, Dettinger P, Renkawitz J, et al. Nano-scale microfluidics to study
3D chemotaxis at the single cell level. PLoS One. 2018;13(6). doi:10.1371/journal.pone.0198330
apa: Frick, C., Dettinger, P., Renkawitz, J., Jauch, A., Berger, C., Recher, M.,
… Mehling, M. (2018). Nano-scale microfluidics to study 3D chemotaxis at the single
cell level. PLoS One. Public Library of Science. https://doi.org/10.1371/journal.pone.0198330
chicago: Frick, Corina, Philip Dettinger, Jörg Renkawitz, Annaïse Jauch, Christoph
Berger, Mike Recher, Timm Schroeder, and Matthias Mehling. “Nano-Scale Microfluidics
to Study 3D Chemotaxis at the Single Cell Level.” PLoS One. Public Library
of Science, 2018. https://doi.org/10.1371/journal.pone.0198330.
ieee: C. Frick et al., “Nano-scale microfluidics to study 3D chemotaxis at
the single cell level,” PLoS One, vol. 13, no. 6. Public Library of Science,
2018.
ista: Frick C, Dettinger P, Renkawitz J, Jauch A, Berger C, Recher M, Schroeder
T, Mehling M. 2018. Nano-scale microfluidics to study 3D chemotaxis at the single
cell level. PLoS One. 13(6), e0198330.
mla: Frick, Corina, et al. “Nano-Scale Microfluidics to Study 3D Chemotaxis at the
Single Cell Level.” PLoS One, vol. 13, no. 6, e0198330, Public Library
of Science, 2018, doi:10.1371/journal.pone.0198330.
short: C. Frick, P. Dettinger, J. Renkawitz, A. Jauch, C. Berger, M. Recher, T.
Schroeder, M. Mehling, PLoS One 13 (2018).
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