---
_id: '10628'
abstract:
- lang: eng
text: The surface states of 3D topological insulators in general have negligible
quantum oscillations (QOs) when the chemical potential is tuned to the Dirac points.
In contrast, we find that topological Kondo insulators (TKIs) can support surface
states with an arbitrarily large Fermi surface (FS) when the chemical potential
is pinned to the Dirac point. We illustrate that these FSs give rise to finite-frequency
QOs, which can become comparable to the extremal area of the unhybridized bulk
bands. We show that this occurs when the crystal symmetry is lowered from cubic
to tetragonal in a minimal two-orbital model. We label such surface modes as 'shadow
surface states'. Moreover, we show that the sufficient next-nearest neighbor out-of-plane
hybridization leading to shadow surface states can be self-consistently stabilized
for tetragonal TKIs. Consequently, shadow surface states provide an important
example of high-frequency QOs beyond the context of cubic TKIs.
acknowledgement: PG acknowledges support from National Science Foundation Awards No.
DMR-1824265 for this work. AG acknowledges support from the European Union's Horizon
2020 research and innovation program under the Marie Skłodowska-Curie Grant Agreement
No. 754411. EMN is supported by ASU startup grant. OE is in part supported by NSF-DMR-1904716.
article_number: '123042'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Areg
full_name: Ghazaryan, Areg
id: 4AF46FD6-F248-11E8-B48F-1D18A9856A87
last_name: Ghazaryan
orcid: 0000-0001-9666-3543
- first_name: Emilian M.
full_name: Nica, Emilian M.
last_name: Nica
- first_name: Onur
full_name: Erten, Onur
last_name: Erten
- first_name: Pouyan
full_name: Ghaemi, Pouyan
last_name: Ghaemi
citation:
ama: Ghazaryan A, Nica EM, Erten O, Ghaemi P. Shadow surface states in topological
Kondo insulators. New Journal of Physics. 2021;23(12). doi:10.1088/1367-2630/ac4124
apa: Ghazaryan, A., Nica, E. M., Erten, O., & Ghaemi, P. (2021). Shadow surface
states in topological Kondo insulators. New Journal of Physics. IOP Publishing.
https://doi.org/10.1088/1367-2630/ac4124
chicago: Ghazaryan, Areg, Emilian M. Nica, Onur Erten, and Pouyan Ghaemi. “Shadow
Surface States in Topological Kondo Insulators.” New Journal of Physics.
IOP Publishing, 2021. https://doi.org/10.1088/1367-2630/ac4124.
ieee: A. Ghazaryan, E. M. Nica, O. Erten, and P. Ghaemi, “Shadow surface states
in topological Kondo insulators,” New Journal of Physics, vol. 23, no.
12. IOP Publishing, 2021.
ista: Ghazaryan A, Nica EM, Erten O, Ghaemi P. 2021. Shadow surface states in topological
Kondo insulators. New Journal of Physics. 23(12), 123042.
mla: Ghazaryan, Areg, et al. “Shadow Surface States in Topological Kondo Insulators.”
New Journal of Physics, vol. 23, no. 12, 123042, IOP Publishing, 2021,
doi:10.1088/1367-2630/ac4124.
short: A. Ghazaryan, E.M. Nica, O. Erten, P. Ghaemi, New Journal of Physics 23 (2021).
date_created: 2022-01-16T23:01:28Z
date_published: 2021-12-23T00:00:00Z
date_updated: 2023-08-17T06:54:54Z
day: '23'
ddc:
- '530'
department:
- _id: MiLe
doi: 10.1088/1367-2630/ac4124
ec_funded: 1
external_id:
arxiv:
- '2012.11625'
isi:
- '000734063700001'
file:
- access_level: open_access
checksum: 0c3cb6816242fa8afd1cc87a5fe77821
content_type: application/pdf
creator: cchlebak
date_created: 2022-01-17T10:01:58Z
date_updated: 2022-01-17T10:01:58Z
file_id: '10632'
file_name: 2021_NewJourPhys_Ghazaryan.pdf
file_size: 2533102
relation: main_file
success: 1
file_date_updated: 2022-01-17T10:01:58Z
has_accepted_license: '1'
intvolume: ' 23'
isi: 1
issue: '12'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '12'
oa: 1
oa_version: Published Version
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: New Journal of Physics
publication_identifier:
issn:
- 1367-2630
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: Shadow surface states in topological Kondo insulators
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 23
year: '2021'
...
---
_id: '10629'
abstract:
- lang: eng
text: "Product graphs arise naturally in formal verification and program analysis.
For example, the analysis of two concurrent threads requires the product of two
component control-flow graphs, and for language inclusion of deterministic automata
the product of two automata is constructed. In many cases, the component graphs
have constant treewidth, e.g., when the input contains control-flow graphs of
programs. We consider the algorithmic analysis of products of two constant-treewidth
graphs with respect to three classic specification languages, namely, (a) algebraic
properties, (b) mean-payoff properties, and (c) initial credit for energy properties.\r\nOur
main contributions are as follows. Consider a graph G that is the product of two
constant-treewidth graphs of size n each. First, given an idempotent semiring,
we present an algorithm that computes the semiring transitive closure of G in
time Õ(n⁴). Since the output has size Θ(n⁴), our algorithm is optimal (up to
polylog factors). Second, given a mean-payoff objective, we present an O(n³)-time
algorithm for deciding whether the value of a starting state is non-negative,
improving the previously known O(n⁴) bound. Third, given an initial credit for
energy objective, we present an O(n⁵)-time algorithm for computing the minimum
initial credit for all nodes of G, improving the previously known O(n⁸) bound.
At the heart of our approach lies an algorithm for the efficient construction
of strongly-balanced tree decompositions of constant-treewidth graphs. Given a
constant-treewidth graph G' of n nodes and a positive integer λ, our algorithm
constructs a binary tree decomposition of G' of width O(λ) with the property that
the size of each subtree decreases geometrically with rate (1/2 + 2^{-λ})."
alternative_title:
- LIPIcs
article_number: '42'
article_processing_charge: No
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Rasmus
full_name: Ibsen-Jensen, Rasmus
id: 3B699956-F248-11E8-B48F-1D18A9856A87
last_name: Ibsen-Jensen
orcid: 0000-0003-4783-0389
- first_name: Andreas
full_name: Pavlogiannis, Andreas
id: 49704004-F248-11E8-B48F-1D18A9856A87
last_name: Pavlogiannis
orcid: 0000-0002-8943-0722
citation:
ama: 'Chatterjee K, Ibsen-Jensen R, Pavlogiannis A. Quantitative verification on
product graphs of small treewidth. In: 41st IARCS Annual Conference on Foundations
of Software Technology and Theoretical Computer Science. Vol 213. Schloss
Dagstuhl - Leibniz-Zentrum für Informatik; 2021. doi:10.4230/LIPIcs.FSTTCS.2021.42'
apa: 'Chatterjee, K., Ibsen-Jensen, R., & Pavlogiannis, A. (2021). Quantitative
verification on product graphs of small treewidth. In 41st IARCS Annual Conference
on Foundations of Software Technology and Theoretical Computer Science (Vol.
213). Virtual: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. https://doi.org/10.4230/LIPIcs.FSTTCS.2021.42'
chicago: Chatterjee, Krishnendu, Rasmus Ibsen-Jensen, and Andreas Pavlogiannis.
“Quantitative Verification on Product Graphs of Small Treewidth.” In 41st IARCS
Annual Conference on Foundations of Software Technology and Theoretical Computer
Science, Vol. 213. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2021.
https://doi.org/10.4230/LIPIcs.FSTTCS.2021.42.
ieee: K. Chatterjee, R. Ibsen-Jensen, and A. Pavlogiannis, “Quantitative verification
on product graphs of small treewidth,” in 41st IARCS Annual Conference on Foundations
of Software Technology and Theoretical Computer Science, Virtual, 2021, vol.
213.
ista: 'Chatterjee K, Ibsen-Jensen R, Pavlogiannis A. 2021. Quantitative verification
on product graphs of small treewidth. 41st IARCS Annual Conference on Foundations
of Software Technology and Theoretical Computer Science. FSTTCS: Foundations of
Software Technology and Theoretical Computer Science, LIPIcs, vol. 213, 42.'
mla: Chatterjee, Krishnendu, et al. “Quantitative Verification on Product Graphs
of Small Treewidth.” 41st IARCS Annual Conference on Foundations of Software
Technology and Theoretical Computer Science, vol. 213, 42, Schloss Dagstuhl
- Leibniz-Zentrum für Informatik, 2021, doi:10.4230/LIPIcs.FSTTCS.2021.42.
short: K. Chatterjee, R. Ibsen-Jensen, A. Pavlogiannis, in:, 41st IARCS Annual Conference
on Foundations of Software Technology and Theoretical Computer Science, Schloss
Dagstuhl - Leibniz-Zentrum für Informatik, 2021.
conference:
end_date: 2021-12-17
location: Virtual
name: 'FSTTCS: Foundations of Software Technology and Theoretical Computer Science'
start_date: 2021-12-15
date_created: 2022-01-16T23:01:28Z
date_published: 2021-11-29T00:00:00Z
date_updated: 2022-01-17T10:39:40Z
day: '29'
ddc:
- '000'
department:
- _id: KrCh
doi: 10.4230/LIPIcs.FSTTCS.2021.42
file:
- access_level: open_access
checksum: 71141acdeffa9056f24d6dbef952d254
content_type: application/pdf
creator: cchlebak
date_created: 2022-01-17T10:36:08Z
date_updated: 2022-01-17T10:36:08Z
file_id: '10633'
file_name: 2021_LIPIcs_Chatterjee.pdf
file_size: 891566
relation: main_file
success: 1
file_date_updated: 2022-01-17T10:36:08Z
has_accepted_license: '1'
intvolume: ' 213'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
publication: 41st IARCS Annual Conference on Foundations of Software Technology and
Theoretical Computer Science
publication_identifier:
isbn:
- 978-3-9597-7215-0
issn:
- 1868-8969
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
quality_controlled: '1'
scopus_import: '1'
status: public
title: Quantitative verification on product graphs of small treewidth
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 213
year: '2021'
...
---
_id: '10630'
abstract:
- lang: eng
text: In the Intersection Non-emptiness problem, we are given a list of finite automata
A_1, A_2,… , A_m over a common alphabet Σ as input, and the goal is to determine
whether some string w ∈ Σ^* lies in the intersection of the languages accepted
by the automata in the list. We analyze the complexity of the Intersection Non-emptiness
problem under the promise that all input automata accept a language in some level
of the dot-depth hierarchy, or some level of the Straubing-Thérien hierarchy.
Automata accepting languages from the lowest levels of these hierarchies arise
naturally in the context of model checking. We identify a dichotomy in the dot-depth
hierarchy by showing that the problem is already NP-complete when all input automata
accept languages of the levels B_0 or B_{1/2} and already PSPACE-hard when all
automata accept a language from the level B_1. Conversely, we identify a tetrachotomy
in the Straubing-Thérien hierarchy. More precisely, we show that the problem is
in AC^0 when restricted to level L_0; complete for L or NL, depending on the input
representation, when restricted to languages in the level L_{1/2}; NP-complete
when the input is given as DFAs accepting a language in L_1 or L_{3/2}; and finally,
PSPACE-complete when the input automata accept languages in level L_2 or higher.
Moreover, we show that the proof technique used to show containment in NP for
DFAs accepting languages in L_1 or L_{3/2} does not generalize to the context
of NFAs. To prove this, we identify a family of languages that provide an exponential
separation between the state complexity of general NFAs and that of partially
ordered NFAs. To the best of our knowledge, this is the first superpolynomial
separation between these two models of computation.
acknowledgement: "We like to thank Lukas Fleischer and Michael Wehar for our discussions.
This work started at the Schloss Dagstuhl Event 20483 Moderne Aspekte der Komplexitätstheorie
in der Automatentheorie https://www.dagstuhl.de/20483.\r\n"
alternative_title:
- LIPIcs
article_number: '34'
article_processing_charge: No
arxiv: 1
author:
- first_name: Emmanuel
full_name: Arrighi, Emmanuel
last_name: Arrighi
- first_name: Henning
full_name: Fernau, Henning
last_name: Fernau
- first_name: Stefan
full_name: Hoffmann, Stefan
last_name: Hoffmann
- first_name: Markus
full_name: Holzer, Markus
last_name: Holzer
- first_name: Ismael R
full_name: Jecker, Ismael R
id: 85D7C63E-7D5D-11E9-9C0F-98C4E5697425
last_name: Jecker
- first_name: Mateus
full_name: De Oliveira Oliveira, Mateus
last_name: De Oliveira Oliveira
- first_name: Petra
full_name: Wolf, Petra
last_name: Wolf
citation:
ama: 'Arrighi E, Fernau H, Hoffmann S, et al. On the complexity of intersection
non-emptiness for star-free language classes. In: 41st IARCS Annual Conference
on Foundations of Software Technology and Theoretical Computer Science. Vol
213. Schloss Dagstuhl - Leibniz Zentrum für Informatik; 2021. doi:10.4230/LIPIcs.FSTTCS.2021.34'
apa: 'Arrighi, E., Fernau, H., Hoffmann, S., Holzer, M., Jecker, I. R., De Oliveira
Oliveira, M., & Wolf, P. (2021). On the complexity of intersection non-emptiness
for star-free language classes. In 41st IARCS Annual Conference on Foundations
of Software Technology and Theoretical Computer Science (Vol. 213). Virtual:
Schloss Dagstuhl - Leibniz Zentrum für Informatik. https://doi.org/10.4230/LIPIcs.FSTTCS.2021.34'
chicago: Arrighi, Emmanuel, Henning Fernau, Stefan Hoffmann, Markus Holzer, Ismael
R Jecker, Mateus De Oliveira Oliveira, and Petra Wolf. “On the Complexity of Intersection
Non-Emptiness for Star-Free Language Classes.” In 41st IARCS Annual Conference
on Foundations of Software Technology and Theoretical Computer Science, Vol.
213. Schloss Dagstuhl - Leibniz Zentrum für Informatik, 2021. https://doi.org/10.4230/LIPIcs.FSTTCS.2021.34.
ieee: E. Arrighi et al., “On the complexity of intersection non-emptiness
for star-free language classes,” in 41st IARCS Annual Conference on Foundations
of Software Technology and Theoretical Computer Science, Virtual, 2021, vol.
213.
ista: 'Arrighi E, Fernau H, Hoffmann S, Holzer M, Jecker IR, De Oliveira Oliveira
M, Wolf P. 2021. On the complexity of intersection non-emptiness for star-free
language classes. 41st IARCS Annual Conference on Foundations of Software Technology
and Theoretical Computer Science. FSTTCS: Foundations of Software Technology and
Theoretical Computer Science, LIPIcs, vol. 213, 34.'
mla: Arrighi, Emmanuel, et al. “On the Complexity of Intersection Non-Emptiness
for Star-Free Language Classes.” 41st IARCS Annual Conference on Foundations
of Software Technology and Theoretical Computer Science, vol. 213, 34, Schloss
Dagstuhl - Leibniz Zentrum für Informatik, 2021, doi:10.4230/LIPIcs.FSTTCS.2021.34.
short: E. Arrighi, H. Fernau, S. Hoffmann, M. Holzer, I.R. Jecker, M. De Oliveira
Oliveira, P. Wolf, in:, 41st IARCS Annual Conference on Foundations of Software
Technology and Theoretical Computer Science, Schloss Dagstuhl - Leibniz Zentrum
für Informatik, 2021.
conference:
end_date: 2021-12-17
location: Virtual
name: 'FSTTCS: Foundations of Software Technology and Theoretical Computer Science'
start_date: 2021-12-15
date_created: 2022-01-16T23:01:29Z
date_published: 2021-11-29T00:00:00Z
date_updated: 2022-01-17T10:56:19Z
day: '29'
ddc:
- '000'
department:
- _id: KrCh
doi: 10.4230/LIPIcs.FSTTCS.2021.34
ec_funded: 1
external_id:
arxiv:
- '2110.01279'
file:
- access_level: open_access
checksum: d5a82ba893c3bc5da5914edbb3efb92b
content_type: application/pdf
creator: cchlebak
date_created: 2022-01-17T10:49:03Z
date_updated: 2022-01-17T10:49:03Z
file_id: '10634'
file_name: 2021_LIPIcs_Arrighi.pdf
file_size: 844224
relation: main_file
success: 1
file_date_updated: 2022-01-17T10:49:03Z
has_accepted_license: '1'
intvolume: ' 213'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: 41st IARCS Annual Conference on Foundations of Software Technology and
Theoretical Computer Science
publication_identifier:
isbn:
- 978-3-9597-7215-0
issn:
- 1868-8969
publication_status: published
publisher: Schloss Dagstuhl - Leibniz Zentrum für Informatik
quality_controlled: '1'
scopus_import: '1'
status: public
title: On the complexity of intersection non-emptiness for star-free language classes
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 213
year: '2021'
...
---
_id: '10631'
abstract:
- lang: eng
text: We combine experimental and theoretical approaches to explore excited rotational
states of molecules embedded in helium nanodroplets using CS2 and I2 as examples.
Laser-induced nonadiabatic molecular alignment is employed to measure spectral
lines for rotational states extending beyond those initially populated at the
0.37 K droplet temperature. We construct a simple quantum-mechanical model, based
on a linear rotor coupled to a single-mode bosonic bath, to determine the rotational
energy structure in its entirety. The calculated and measured spectral lines are
in good agreement. We show that the effect of the surrounding superfluid on molecular
rotation can be rationalized by a single quantity, the angular momentum, transferred
from the molecule to the droplet.
acknowledgement: I.C. acknowledges the support by the European Union’s Horizon 2020
research and innovation programme under the Marie Sklodowska-Curie Grant Agreement
No. 665385. G.B. acknowledges support from the Austrian Science Fund (FWF), under
project No. M2461-N27. M.L. acknowledges support by the Austrian Science Fund (FWF),
under project No. P29902-N27, and by the European Research Council (ERC) Starting
Grant No. 801770 (ANGULON). H.S acknowledges support from the European Research
Council-AdG (Project No. 320459, DropletControl) and from The Villum Foundation
through a Villum Investigator grant no. 25886.
article_number: L061303
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Igor
full_name: Cherepanov, Igor
id: 339C7E5A-F248-11E8-B48F-1D18A9856A87
last_name: Cherepanov
- first_name: Giacomo
full_name: Bighin, Giacomo
id: 4CA96FD4-F248-11E8-B48F-1D18A9856A87
last_name: Bighin
orcid: 0000-0001-8823-9777
- first_name: Constant A.
full_name: Schouder, Constant A.
last_name: Schouder
- first_name: Adam S.
full_name: Chatterley, Adam S.
last_name: Chatterley
- first_name: Simon H.
full_name: Albrechtsen, Simon H.
last_name: Albrechtsen
- first_name: Alberto Viñas
full_name: Muñoz, Alberto Viñas
last_name: Muñoz
- first_name: Lars
full_name: Christiansen, Lars
last_name: Christiansen
- first_name: Henrik
full_name: Stapelfeldt, Henrik
last_name: Stapelfeldt
- first_name: Mikhail
full_name: Lemeshko, Mikhail
id: 37CB05FA-F248-11E8-B48F-1D18A9856A87
last_name: Lemeshko
orcid: 0000-0002-6990-7802
citation:
ama: Cherepanov I, Bighin G, Schouder CA, et al. Excited rotational states of molecules
in a superfluid. Physical Review A. 2021;104(6). doi:10.1103/PhysRevA.104.L061303
apa: Cherepanov, I., Bighin, G., Schouder, C. A., Chatterley, A. S., Albrechtsen,
S. H., Muñoz, A. V., … Lemeshko, M. (2021). Excited rotational states of molecules
in a superfluid. Physical Review A. American Physical Society. https://doi.org/10.1103/PhysRevA.104.L061303
chicago: Cherepanov, Igor, Giacomo Bighin, Constant A. Schouder, Adam S. Chatterley,
Simon H. Albrechtsen, Alberto Viñas Muñoz, Lars Christiansen, Henrik Stapelfeldt,
and Mikhail Lemeshko. “Excited Rotational States of Molecules in a Superfluid.”
Physical Review A. American Physical Society, 2021. https://doi.org/10.1103/PhysRevA.104.L061303.
ieee: I. Cherepanov et al., “Excited rotational states of molecules in a
superfluid,” Physical Review A, vol. 104, no. 6. American Physical Society,
2021.
ista: Cherepanov I, Bighin G, Schouder CA, Chatterley AS, Albrechtsen SH, Muñoz
AV, Christiansen L, Stapelfeldt H, Lemeshko M. 2021. Excited rotational states
of molecules in a superfluid. Physical Review A. 104(6), L061303.
mla: Cherepanov, Igor, et al. “Excited Rotational States of Molecules in a Superfluid.”
Physical Review A, vol. 104, no. 6, L061303, American Physical Society,
2021, doi:10.1103/PhysRevA.104.L061303.
short: I. Cherepanov, G. Bighin, C.A. Schouder, A.S. Chatterley, S.H. Albrechtsen,
A.V. Muñoz, L. Christiansen, H. Stapelfeldt, M. Lemeshko, Physical Review A 104
(2021).
date_created: 2022-01-16T23:01:29Z
date_published: 2021-12-30T00:00:00Z
date_updated: 2024-08-07T07:16:52Z
day: '30'
department:
- _id: MiLe
doi: 10.1103/PhysRevA.104.L061303
ec_funded: 1
external_id:
arxiv:
- '2107.00468'
isi:
- '000739618300001'
intvolume: ' 104'
isi: 1
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://128.84.4.18/abs/2107.00468
month: '12'
oa: 1
oa_version: Preprint
project:
- _id: 26031614-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P29902
name: Quantum rotations in the presence of a many-body environment
- _id: 2688CF98-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '801770'
name: 'Angulon: physics and applications of a new quasiparticle'
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
- _id: 26986C82-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: M02641
name: A path-integral approach to composite impurities
publication: Physical Review A
publication_identifier:
eissn:
- 2469-9934
issn:
- 2469-9926
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Excited rotational states of molecules in a superfluid
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 104
year: '2021'
...
---
_id: '10635'
abstract:
- lang: eng
text: The brain efficiently performs nonlinear computations through its intricate
networks of spiking neurons, but how this is done remains elusive. While nonlinear
computations can be implemented successfully in spiking neural networks, this
requires supervised training and the resulting connectivity can be hard to interpret.
In contrast, the required connectivity for any computation in the form of a linear
dynamical system can be directly derived and understood with the spike coding
network (SCN) framework. These networks also have biologically realistic activity
patterns and are highly robust to cell death. Here we extend the SCN framework
to directly implement any polynomial dynamical system, without the need for training.
This results in networks requiring a mix of synapse types (fast, slow, and multiplicative),
which we term multiplicative spike coding networks (mSCNs). Using mSCNs, we demonstrate
how to directly derive the required connectivity for several nonlinear dynamical
systems. We also show how to carry out higher-order polynomials with coupled networks
that use only pair-wise multiplicative synapses, and provide expected numbers
of connections for each synapse type. Overall, our work demonstrates a novel method
for implementing nonlinear computations in spiking neural networks, while keeping
the attractive features of standard SCNs (robustness, realistic activity patterns,
and interpretable connectivity). Finally, we discuss the biological plausibility
of our approach, and how the high accuracy and robustness of the approach may
be of interest for neuromorphic computing.
acknowledgement: "A preprint version of this article has been peer-reviewed and recommended
by Peer Community In Neuroscience (DOI link to the recommendation: https://doi.org/10.24072/pci.cneuro.100003).\r\nWe
thank Christian Machens and Nuno Calaim for useful discussions on the project. This
report\r\ncame out of a collaboration started at the CAJAL Advanced Neuroscience
Training Programme in\r\nComputational Neuroscience in Lisbon, Portugal, during
the 2019 summer. The authors would\r\nlike to thank the participants, TAs, lecturers,
and organizers of the summer school. SWK was\r\nsupported by the Simons Collaboration
on the Global Brain (543009). WFP was supported by\r\nFCT (032077). MN was supported
by European Union Horizon 2020 (665385).\r\n"
article_number: e68
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Michele
full_name: Nardin, Michele
id: 30BD0376-F248-11E8-B48F-1D18A9856A87
last_name: Nardin
orcid: 0000-0001-8849-6570
- first_name: James W.
full_name: Phillips, James W.
last_name: Phillips
- first_name: William F.
full_name: Podlaski, William F.
last_name: Podlaski
- first_name: Sander W.
full_name: Keemink, Sander W.
last_name: Keemink
citation:
ama: Nardin M, Phillips JW, Podlaski WF, Keemink SW. Nonlinear computations in spiking
neural networks through multiplicative synapses. Peer Community Journal.
2021;1. doi:10.24072/pcjournal.69
apa: Nardin, M., Phillips, J. W., Podlaski, W. F., & Keemink, S. W. (2021).
Nonlinear computations in spiking neural networks through multiplicative synapses.
Peer Community Journal. Centre Mersenne ; Peer Community In. https://doi.org/10.24072/pcjournal.69
chicago: Nardin, Michele, James W. Phillips, William F. Podlaski, and Sander W.
Keemink. “Nonlinear Computations in Spiking Neural Networks through Multiplicative
Synapses.” Peer Community Journal. Centre Mersenne ; Peer Community In,
2021. https://doi.org/10.24072/pcjournal.69.
ieee: M. Nardin, J. W. Phillips, W. F. Podlaski, and S. W. Keemink, “Nonlinear computations
in spiking neural networks through multiplicative synapses,” Peer Community
Journal, vol. 1. Centre Mersenne ; Peer Community In, 2021.
ista: Nardin M, Phillips JW, Podlaski WF, Keemink SW. 2021. Nonlinear computations
in spiking neural networks through multiplicative synapses. Peer Community Journal.
1, e68.
mla: Nardin, Michele, et al. “Nonlinear Computations in Spiking Neural Networks
through Multiplicative Synapses.” Peer Community Journal, vol. 1, e68,
Centre Mersenne ; Peer Community In, 2021, doi:10.24072/pcjournal.69.
short: M. Nardin, J.W. Phillips, W.F. Podlaski, S.W. Keemink, Peer Community Journal
1 (2021).
date_created: 2022-01-17T11:12:40Z
date_published: 2021-12-15T00:00:00Z
date_updated: 2022-01-17T13:30:01Z
day: '15'
ddc:
- '519'
department:
- _id: GradSch
- _id: JoCs
doi: 10.24072/pcjournal.69
ec_funded: 1
external_id:
arxiv:
- '2009.03857'
file:
- access_level: open_access
checksum: cd9af6b331918608f2e3d1c7940cbf4f
content_type: application/pdf
creator: mnardin
date_created: 2022-01-17T11:15:26Z
date_updated: 2022-01-17T11:15:26Z
file_id: '10636'
file_name: 10_24072_pcjournal_69.pdf
file_size: 3311494
relation: main_file
success: 1
file_date_updated: 2022-01-17T11:15:26Z
has_accepted_license: '1'
intvolume: ' 1'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication: Peer Community Journal
publication_identifier:
eissn:
- 2804-3871
publication_status: published
publisher: Centre Mersenne ; Peer Community In
quality_controlled: '1'
status: public
title: Nonlinear computations in spiking neural networks through multiplicative synapses
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 1
year: '2021'
...
---
_id: '10644'
abstract:
- lang: eng
text: The purpose of this application note is to demonstrate a working example of
a superconducting qubit measurement in a Bluefors cryostat using the Keysight
quantum control hardware. Our motivation is twofold. First, we provide pre-qualification
data that the Bluefors cryostat, including filtering and wiring, can support long-lived
qubits. Second, we demonstrate that the Keysight system (controlled using Labber)
provides a straightforward solution to perform these characterization measurements.
This document is intended as a brief guide for starting an experimental platform
for testing superconducting qubits. The setup described here is an immediate jumping
off point for a suite of applications including testing quantum logical gates,
quantum optics with microwaves, or even using the qubit itself as a sensitive
probe of local electromagnetic fields. Qubit measurements rely on high performance
of both the physical sample environment and the measurement electronics. An overview
of the cryogenic system is shown in Figure 1, and an overview of the integration
between the electronics and cryostat (including wiring details) is shown in Figure
2.
alternative_title:
- Bluefors Blog
article_processing_charge: No
author:
- first_name: Russell
full_name: Lake, Russell
last_name: Lake
- first_name: Slawomir
full_name: Simbierowicz, Slawomir
last_name: Simbierowicz
- first_name: Philip
full_name: Krantz, Philip
last_name: Krantz
- first_name: Farid
full_name: Hassani, Farid
id: 2AED110C-F248-11E8-B48F-1D18A9856A87
last_name: Hassani
- first_name: Johannes M
full_name: Fink, Johannes M
id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
last_name: Fink
orcid: 0000-0001-8112-028X
citation:
ama: 'Lake R, Simbierowicz S, Krantz P, Hassani F, Fink JM. The Bluefors Dilution
Refrigerator as an Integrated Quantum Measurement System. Helsinki, Finland:
Bluefors Oy; 2021.'
apa: 'Lake, R., Simbierowicz, S., Krantz, P., Hassani, F., & Fink, J. M. (2021).
The Bluefors dilution refrigerator as an integrated quantum measurement system.
Helsinki, Finland: Bluefors Oy.'
chicago: 'Lake, Russell, Slawomir Simbierowicz, Philip Krantz, Farid Hassani, and
Johannes M Fink. The Bluefors Dilution Refrigerator as an Integrated Quantum
Measurement System. Helsinki, Finland: Bluefors Oy, 2021.'
ieee: 'R. Lake, S. Simbierowicz, P. Krantz, F. Hassani, and J. M. Fink, The Bluefors
dilution refrigerator as an integrated quantum measurement system. Helsinki,
Finland: Bluefors Oy, 2021.'
ista: 'Lake R, Simbierowicz S, Krantz P, Hassani F, Fink JM. 2021. The Bluefors
dilution refrigerator as an integrated quantum measurement system, Helsinki, Finland:
Bluefors Oy, 9p.'
mla: Lake, Russell, et al. The Bluefors Dilution Refrigerator as an Integrated
Quantum Measurement System. Bluefors Oy, 2021.
short: R. Lake, S. Simbierowicz, P. Krantz, F. Hassani, J.M. Fink, The Bluefors
Dilution Refrigerator as an Integrated Quantum Measurement System, Bluefors Oy,
Helsinki, Finland, 2021.
date_created: 2022-01-19T08:29:57Z
date_published: 2021-04-20T00:00:00Z
date_updated: 2022-01-19T09:11:33Z
day: '20'
department:
- _id: JoFi
keyword:
- Application note
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://bluefors.com/blog/integrated-quantum-measurement-system/
month: '04'
oa: 1
oa_version: Published Version
page: '9'
place: Helsinki, Finland
publication_status: published
publisher: Bluefors Oy
quality_controlled: '1'
status: public
title: The Bluefors dilution refrigerator as an integrated quantum measurement system
type: other_academic_publication
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2021'
...
---
_id: '10645'
abstract:
- lang: eng
text: "Superconducting qubits have emerged as a highly versatile and useful platform
for quantum technological applications [1]. Bluefors and Zurich Instruments have
supported the growth of this field from the 2010s onwards by providing well-engineered
and reliable measurement infrastructure [2]– [6]. Having a long and stable qubit
lifetime is a critical system property. Therefore, considerable effort has already
gone into measuring qubit energy-relaxation timescales and their fluctuations,
see Refs. [7]–[10] among others. Accurately extracting the statistics of a quantum
device requires users to perform time consuming measurements. One measurement
challenge is that the detection of the state-dependent\r\nresponse of a superconducting
resonator due to a dispersively-coupled qubit requires an inherently low signal
level. Consequently, measurements must be performed using a microwave probe that
contains only a few microwave photons. Improving the signal-to-noise ratio (SNR)
by using near-quantum limited parametric amplifiers as well as the use of optimized
signal processing enabled by efficient room temperature instrumentation help to
reduce measurement time. An empirical observation for fixed frequency transmons
from recent literature is that as the energy-relaxation time \U0001D447\U0001D4471
increases, so do its natural temporal fluctuations [7], [10]. This necessitates
many repeated measurements to understand the statistics (see for example, Ref.
[10]). In addition, as state-of-the-art qubits increase in lifetime, longer\r\nmeasurement
times are expected to obtain accurate statistics. As described below, the scaling
of the widths of the qubit energy-relaxation distributions also reveal clues about
the origin of the energy-relaxation."
alternative_title:
- Bluefors Blog
article_processing_charge: No
author:
- first_name: Slawomir
full_name: Simbierowicz, Slawomir
last_name: Simbierowicz
- first_name: Chunyan
full_name: Shi, Chunyan
last_name: Shi
- first_name: Michele
full_name: Collodo, Michele
last_name: Collodo
- first_name: Moritz
full_name: Kirste, Moritz
last_name: Kirste
- first_name: Farid
full_name: Hassani, Farid
id: 2AED110C-F248-11E8-B48F-1D18A9856A87
last_name: Hassani
- first_name: Johannes M
full_name: Fink, Johannes M
id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
last_name: Fink
orcid: 0000-0001-8112-028X
- first_name: Jonas
full_name: Bylander, Jonas
last_name: Bylander
- first_name: Daniel
full_name: Perez Lozano, Daniel
last_name: Perez Lozano
- first_name: Russell
full_name: Lake, Russell
last_name: Lake
citation:
ama: 'Simbierowicz S, Shi C, Collodo M, et al. Qubit Energy-Relaxation Statistics
in the Bluefors Quantum Measurement System. Helsinki, Finland: Bluefors Oy;
2021.'
apa: 'Simbierowicz, S., Shi, C., Collodo, M., Kirste, M., Hassani, F., Fink, J.
M., … Lake, R. (2021). Qubit energy-relaxation statistics in the Bluefors quantum
measurement system. Helsinki, Finland: Bluefors Oy.'
chicago: 'Simbierowicz, Slawomir, Chunyan Shi, Michele Collodo, Moritz Kirste, Farid
Hassani, Johannes M Fink, Jonas Bylander, Daniel Perez Lozano, and Russell Lake.
Qubit Energy-Relaxation Statistics in the Bluefors Quantum Measurement System.
Helsinki, Finland: Bluefors Oy, 2021.'
ieee: 'S. Simbierowicz et al., Qubit energy-relaxation statistics in the
Bluefors quantum measurement system. Helsinki, Finland: Bluefors Oy, 2021.'
ista: 'Simbierowicz S, Shi C, Collodo M, Kirste M, Hassani F, Fink JM, Bylander
J, Perez Lozano D, Lake R. 2021. Qubit energy-relaxation statistics in the Bluefors
quantum measurement system, Helsinki, Finland: Bluefors Oy, 8p.'
mla: Simbierowicz, Slawomir, et al. Qubit Energy-Relaxation Statistics in the
Bluefors Quantum Measurement System. Bluefors Oy, 2021.
short: S. Simbierowicz, C. Shi, M. Collodo, M. Kirste, F. Hassani, J.M. Fink, J.
Bylander, D. Perez Lozano, R. Lake, Qubit Energy-Relaxation Statistics in the
Bluefors Quantum Measurement System, Bluefors Oy, Helsinki, Finland, 2021.
date_created: 2022-01-19T08:41:14Z
date_published: 2021-06-03T00:00:00Z
date_updated: 2022-01-19T09:11:39Z
day: '03'
department:
- _id: JoFi
keyword:
- Application note
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://bluefors.com/blog/application-note-qubit-energy-relaxation-statistics-bluefors-quantum-measurement-system/
month: '06'
oa: 1
oa_version: Published Version
page: '8'
place: Helsinki, Finland
publication_status: published
publisher: Bluefors Oy
quality_controlled: '1'
status: public
title: Qubit energy-relaxation statistics in the Bluefors quantum measurement system
type: other_academic_publication
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2021'
...
---
_id: '10655'
abstract:
- lang: eng
text: "Adeno-associated viruses (AAVs) are widely used to deliver genetic material
in vivo to distinct cell types such as neurons or glial cells, allowing for targeted
manipulation. Transduction of microglia is mostly excluded from this strategy,
likely due to the cells’ heterogeneous state upon environmental changes, which
makes AAV design challenging. Here, we established the retina as a model system
for microglial AAV validation and optimization. First, we show that AAV2/6 transduced
microglia in both synaptic layers, where layer preference corresponds to the intravitreal
or subretinal delivery method. Surprisingly, we observed significantly enhanced
microglial transduction during photoreceptor degeneration. Thus, we modified the
AAV6 capsid to reduce heparin binding by introducing four point mutations (K531E,
R576Q, K493S, and K459S), resulting in increased microglial transduction in the
outer plexiform layer. Finally, to improve microglial-specific transduction, we
validated a Cre-dependent transgene delivery cassette for use in combination with
the Cx3cr1CreERT2 mouse line. Together, our results provide a foundation for future
studies optimizing AAV-mediated microglia transduction and highlight that environmental
conditions influence microglial transduction efficiency.\r\n"
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
- _id: PreCl
acknowledgement: This project has received funding from the European Research Council
(ERC) under the European Union’s Horizon 2020 research and innovation programme
(grant agreement no. 715571). The research was supported by the Scientific Service
Units (SSU) of IST Austria through resources provided by the Bioimaging Facility,
the Life Science Facility, and the Pre-Clinical Facility, namely Sonja Haslinger
and Michael Schunn for their animal colony management and support. We would also
like to thank Chakrabarty Lab for sharing the plasmids for AAV2/6 production. Finally,
we would like to thank the Siegert team members for discussion about the manuscript.
article_processing_charge: Yes
article_type: original
author:
- first_name: Margaret E
full_name: Maes, Margaret E
id: 3838F452-F248-11E8-B48F-1D18A9856A87
last_name: Maes
orcid: 0000-0001-9642-1085
- first_name: Gabriele M.
full_name: Wögenstein, Gabriele M.
last_name: Wögenstein
- first_name: Gloria
full_name: Colombo, Gloria
id: 3483CF6C-F248-11E8-B48F-1D18A9856A87
last_name: Colombo
orcid: 0000-0001-9434-8902
- first_name: Raquel
full_name: Casado Polanco, Raquel
id: 15240fc1-dbcd-11ea-9d1d-ac5a786425fd
last_name: Casado Polanco
orcid: 0000-0001-8293-4568
- first_name: Sandra
full_name: Siegert, Sandra
id: 36ACD32E-F248-11E8-B48F-1D18A9856A87
last_name: Siegert
orcid: 0000-0001-8635-0877
citation:
ama: Maes ME, Wögenstein GM, Colombo G, Casado Polanco R, Siegert S. Optimizing
AAV2/6 microglial targeting identified enhanced efficiency in the photoreceptor
degenerative environment. Molecular Therapy - Methods and Clinical Development.
2021;23:210-224. doi:10.1016/j.omtm.2021.09.006
apa: Maes, M. E., Wögenstein, G. M., Colombo, G., Casado Polanco, R., & Siegert,
S. (2021). Optimizing AAV2/6 microglial targeting identified enhanced efficiency
in the photoreceptor degenerative environment. Molecular Therapy - Methods
and Clinical Development. Elsevier. https://doi.org/10.1016/j.omtm.2021.09.006
chicago: Maes, Margaret E, Gabriele M. Wögenstein, Gloria Colombo, Raquel Casado
Polanco, and Sandra Siegert. “Optimizing AAV2/6 Microglial Targeting Identified
Enhanced Efficiency in the Photoreceptor Degenerative Environment.” Molecular
Therapy - Methods and Clinical Development. Elsevier, 2021. https://doi.org/10.1016/j.omtm.2021.09.006.
ieee: M. E. Maes, G. M. Wögenstein, G. Colombo, R. Casado Polanco, and S. Siegert,
“Optimizing AAV2/6 microglial targeting identified enhanced efficiency in the
photoreceptor degenerative environment,” Molecular Therapy - Methods and Clinical
Development, vol. 23. Elsevier, pp. 210–224, 2021.
ista: Maes ME, Wögenstein GM, Colombo G, Casado Polanco R, Siegert S. 2021. Optimizing
AAV2/6 microglial targeting identified enhanced efficiency in the photoreceptor
degenerative environment. Molecular Therapy - Methods and Clinical Development.
23, 210–224.
mla: Maes, Margaret E., et al. “Optimizing AAV2/6 Microglial Targeting Identified
Enhanced Efficiency in the Photoreceptor Degenerative Environment.” Molecular
Therapy - Methods and Clinical Development, vol. 23, Elsevier, 2021, pp. 210–24,
doi:10.1016/j.omtm.2021.09.006.
short: M.E. Maes, G.M. Wögenstein, G. Colombo, R. Casado Polanco, S. Siegert, Molecular
Therapy - Methods and Clinical Development 23 (2021) 210–224.
date_created: 2022-01-23T23:01:28Z
date_published: 2021-12-10T00:00:00Z
date_updated: 2023-11-16T13:12:03Z
day: '10'
ddc:
- '570'
department:
- _id: SaSi
- _id: SiHi
doi: 10.1016/j.omtm.2021.09.006
ec_funded: 1
external_id:
isi:
- '000748748500019'
file:
- access_level: open_access
checksum: 77dc540e8011c5475031bdf6ccef20a6
content_type: application/pdf
creator: cchlebak
date_created: 2022-01-24T07:43:09Z
date_updated: 2022-01-24T07:43:09Z
file_id: '10657'
file_name: 2021_MolTherMethodsClinDev_Maes.pdf
file_size: 4794147
relation: main_file
success: 1
file_date_updated: 2022-01-24T07:43:09Z
has_accepted_license: '1'
intvolume: ' 23'
isi: 1
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: 210-224
project:
- _id: 25D4A630-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '715571'
name: Microglia action towards neuronal circuit formation and function in health
and disease
publication: Molecular Therapy - Methods and Clinical Development
publication_identifier:
eissn:
- 2329-0501
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Optimizing AAV2/6 microglial targeting identified enhanced efficiency in the
photoreceptor degenerative environment
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 23
year: '2021'
...
---
_id: '12076'
abstract:
- lang: eng
text: We find an asymptotic formula for the number of primitive vectors $(z_1,\ldots,z_4)\in
(\mathbb{Z}_{\neq 0})^4$ such that $z_1,\ldots, z_4$ are all squareful and bounded
by $B$, and $z_1+\cdots + z_4 = 0$. Our result agrees in the power of $B$ and
$\log B$ with the Campana-Manin conjecture of Pieropan, Smeets, Tanimoto and V\'{a}rilly-Alvarado.
article_number: '2104.06966'
article_processing_charge: No
arxiv: 1
author:
- first_name: Alec L
full_name: Shute, Alec L
id: 440EB050-F248-11E8-B48F-1D18A9856A87
last_name: Shute
orcid: 0000-0002-1812-2810
citation:
ama: Shute AL. Sums of four squareful numbers. arXiv. doi:10.48550/arXiv.2104.06966
apa: Shute, A. L. (n.d.). Sums of four squareful numbers. arXiv. https://doi.org/10.48550/arXiv.2104.06966
chicago: Shute, Alec L. “Sums of Four Squareful Numbers.” ArXiv, n.d. https://doi.org/10.48550/arXiv.2104.06966.
ieee: A. L. Shute, “Sums of four squareful numbers,” arXiv. .
ista: Shute AL. Sums of four squareful numbers. arXiv, 2104.06966.
mla: Shute, Alec L. “Sums of Four Squareful Numbers.” ArXiv, 2104.06966,
doi:10.48550/arXiv.2104.06966.
short: A.L. Shute, ArXiv (n.d.).
date_created: 2022-09-09T10:42:51Z
date_published: 2021-04-15T00:00:00Z
date_updated: 2023-02-21T16:37:30Z
day: '15'
department:
- _id: TiBr
doi: 10.48550/arXiv.2104.06966
external_id:
arxiv:
- '2104.06966'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2104.06966
month: '04'
oa: 1
oa_version: Preprint
publication: arXiv
publication_status: submitted
related_material:
record:
- id: '12072'
relation: dissertation_contains
status: public
status: public
title: Sums of four squareful numbers
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2021'
...
---
_id: '12077'
abstract:
- lang: eng
text: "We compare the Manin-type conjecture for Campana points recently formulated\r\nby
Pieropan, Smeets, Tanimoto and V\\'{a}rilly-Alvarado with an alternative\r\nprediction
of Browning and Van Valckenborgh in the special case of the orbifold\r\n$(\\mathbb{P}^1,D)$,
where $D =\\frac{1}{2}[0]+\\frac{1}{2}[1]+\\frac{1}{2}[\\infty]$. We find that
the two predicted leading constants do not agree, and we discuss whether thin
sets\r\ncould explain this discrepancy. Motivated by this, we provide a counterexample\r\nto
the Manin-type conjecture for Campana points, by considering orbifolds\r\ncorresponding
to squareful values of binary quadratic forms."
acknowledgement: The author would like to thank Damaris Schindler and Florian Wilsch
for their helpful comments on the heights and Tamagawa measures used in Section
3, together with Marta Pieropan, Sho Tanimoto and Sam Streeter for providing valuable
feedback on an earlier version of this paper, and Tim Browning for many useful comments
and discussions during the development of this work. The author is also grateful
to the anonymous referee for providing many valuable comments and suggestions that
improved the quality of the paper.
article_number: '2104.14946'
article_processing_charge: No
arxiv: 1
author:
- first_name: Alec L
full_name: Shute, Alec L
id: 440EB050-F248-11E8-B48F-1D18A9856A87
last_name: Shute
orcid: 0000-0002-1812-2810
citation:
ama: Shute AL. On the leading constant in the Manin-type conjecture for Campana
points. arXiv. doi:10.48550/arXiv.2104.14946
apa: Shute, A. L. (n.d.). On the leading constant in the Manin-type conjecture for
Campana points. arXiv. https://doi.org/10.48550/arXiv.2104.14946
chicago: Shute, Alec L. “On the Leading Constant in the Manin-Type Conjecture for
Campana Points.” ArXiv, n.d. https://doi.org/10.48550/arXiv.2104.14946.
ieee: A. L. Shute, “On the leading constant in the Manin-type conjecture for Campana
points,” arXiv. .
ista: Shute AL. On the leading constant in the Manin-type conjecture for Campana
points. arXiv, 2104.14946.
mla: Shute, Alec L. “On the Leading Constant in the Manin-Type Conjecture for Campana
Points.” ArXiv, 2104.14946, doi:10.48550/arXiv.2104.14946.
short: A.L. Shute, ArXiv (n.d.).
date_created: 2022-09-09T10:43:17Z
date_published: 2021-04-30T00:00:00Z
date_updated: 2023-02-21T16:37:30Z
day: '30'
department:
- _id: TiBr
doi: 10.48550/arXiv.2104.14946
external_id:
arxiv:
- '2104.14946'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2104.14946
month: '04'
oa: 1
oa_version: Preprint
publication: arXiv
publication_status: submitted
related_material:
record:
- id: '12072'
relation: dissertation_contains
status: public
status: public
title: On the leading constant in the Manin-type conjecture for Campana points
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2021'
...
---
_id: '12767'
abstract:
- lang: eng
text: "Several problems in planning and reactive synthesis can be reduced to the
analysis of two-player quantitative graph games. Optimization is one form of analysis.
We argue that in many cases it may be better to replace the optimization problem
with the satisficing problem, where instead of searching for optimal solutions,
the goal is to search for solutions that adhere to a given threshold bound.\r\nThis
work defines and investigates the satisficing problem on a two-player graph game
with the discounted-sum cost model. We show that while the satisficing problem
can be solved using numerical methods just like the optimization problem, this
approach does not render compelling benefits over optimization. When the discount
factor is, however, an integer, we present another approach to satisficing, which
is purely based on automata methods. We show that this approach is algorithmically
more performant – both theoretically and empirically – and demonstrates the broader
applicability of satisficing over optimization."
acknowledgement: We thank anonymous reviewers for valuable inputs. This work is supported
in part by NSF grant 2030859 to the CRA for the CIFellows Project, NSF grants IIS-1527668,
CCF-1704883, IIS-1830549, the ERC CoG 863818 (ForM-SMArt), and an award from the
Maryland Procurement Office.
alternative_title:
- LNCS
article_processing_charge: No
arxiv: 1
author:
- first_name: Suguman
full_name: Bansal, Suguman
last_name: Bansal
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Moshe Y.
full_name: Vardi, Moshe Y.
last_name: Vardi
citation:
ama: 'Bansal S, Chatterjee K, Vardi MY. On satisficing in quantitative games. In:
27th International Conference on Tools and Algorithms for the Construction
and Analysis of Systems. Vol 12651. Springer Nature; 2021:20-37. doi:10.1007/978-3-030-72016-2'
apa: 'Bansal, S., Chatterjee, K., & Vardi, M. Y. (2021). On satisficing in quantitative
games. In 27th International Conference on Tools and Algorithms for the Construction
and Analysis of Systems (Vol. 12651, pp. 20–37). Luxembourg City, Luxembourg:
Springer Nature. https://doi.org/10.1007/978-3-030-72016-2'
chicago: Bansal, Suguman, Krishnendu Chatterjee, and Moshe Y. Vardi. “On Satisficing
in Quantitative Games.” In 27th International Conference on Tools and Algorithms
for the Construction and Analysis of Systems, 12651:20–37. Springer Nature,
2021. https://doi.org/10.1007/978-3-030-72016-2.
ieee: S. Bansal, K. Chatterjee, and M. Y. Vardi, “On satisficing in quantitative
games,” in 27th International Conference on Tools and Algorithms for the Construction
and Analysis of Systems, Luxembourg City, Luxembourg, 2021, vol. 12651, pp.
20–37.
ista: 'Bansal S, Chatterjee K, Vardi MY. 2021. On satisficing in quantitative games.
27th International Conference on Tools and Algorithms for the Construction and
Analysis of Systems. TACAS: Tools and Algorithms for the Construction and Analysis
of Systems, LNCS, vol. 12651, 20–37.'
mla: Bansal, Suguman, et al. “On Satisficing in Quantitative Games.” 27th International
Conference on Tools and Algorithms for the Construction and Analysis of Systems,
vol. 12651, Springer Nature, 2021, pp. 20–37, doi:10.1007/978-3-030-72016-2.
short: S. Bansal, K. Chatterjee, M.Y. Vardi, in:, 27th International Conference
on Tools and Algorithms for the Construction and Analysis of Systems, Springer
Nature, 2021, pp. 20–37.
conference:
end_date: 2021-04-01
location: Luxembourg City, Luxembourg
name: 'TACAS: Tools and Algorithms for the Construction and Analysis of Systems'
start_date: 2021-03-27
date_created: 2023-03-26T22:01:09Z
date_published: 2021-03-21T00:00:00Z
date_updated: 2025-07-14T09:09:51Z
day: '21'
ddc:
- '000'
department:
- _id: KrCh
doi: 10.1007/978-3-030-72016-2
ec_funded: 1
external_id:
arxiv:
- '2101.02594'
file:
- access_level: open_access
checksum: b020b78b23587ce7610b1aafb4e63438
content_type: application/pdf
creator: dernst
date_created: 2023-03-28T11:00:33Z
date_updated: 2023-03-28T11:00:33Z
file_id: '12777'
file_name: 2021_LNCS_Bansal.pdf
file_size: 747418
relation: main_file
success: 1
file_date_updated: 2023-03-28T11:00:33Z
has_accepted_license: '1'
intvolume: ' 12651'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 20-37
project:
- _id: 0599E47C-7A3F-11EA-A408-12923DDC885E
call_identifier: H2020
grant_number: '863818'
name: 'Formal Methods for Stochastic Models: Algorithms and Applications'
publication: 27th International Conference on Tools and Algorithms for the Construction
and Analysis of Systems
publication_identifier:
eissn:
- 1611-3349
isbn:
- '9783030720155'
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: On satisficing in quantitative games
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12651
year: '2021'
...
---
_id: '12909'
article_processing_charge: No
author:
- first_name: Alois
full_name: Schlögl, Alois
id: 45BF87EE-F248-11E8-B48F-1D18A9856A87
last_name: Schlögl
orcid: 0000-0002-5621-8100
- first_name: Stefano
full_name: Elefante, Stefano
id: 490F40CE-F248-11E8-B48F-1D18A9856A87
last_name: Elefante
- first_name: Andrei
full_name: Hornoiu, Andrei
id: 77129392-B450-11EA-8745-D4653DDC885E
last_name: Hornoiu
- first_name: Stephan
full_name: Stadlbauer, Stephan
id: 4D0BC184-F248-11E8-B48F-1D18A9856A87
last_name: Stadlbauer
citation:
ama: 'Schlögl A, Elefante S, Hornoiu A, Stadlbauer S. Managing software on a heterogenous
HPC cluster. In: ASHPC21 – Austrian-Slovenian HPC Meeting 2021. University
of Ljubljana; 2021:5. doi:10.3359/2021hpc'
apa: 'Schlögl, A., Elefante, S., Hornoiu, A., & Stadlbauer, S. (2021). Managing
software on a heterogenous HPC cluster. In ASHPC21 – Austrian-Slovenian HPC
Meeting 2021 (p. 5). Virtual: University of Ljubljana. https://doi.org/10.3359/2021hpc'
chicago: Schlögl, Alois, Stefano Elefante, Andrei Hornoiu, and Stephan Stadlbauer.
“Managing Software on a Heterogenous HPC Cluster.” In ASHPC21 – Austrian-Slovenian
HPC Meeting 2021, 5. University of Ljubljana, 2021. https://doi.org/10.3359/2021hpc.
ieee: A. Schlögl, S. Elefante, A. Hornoiu, and S. Stadlbauer, “Managing software
on a heterogenous HPC cluster,” in ASHPC21 – Austrian-Slovenian HPC Meeting
2021, Virtual, 2021, p. 5.
ista: Schlögl A, Elefante S, Hornoiu A, Stadlbauer S. 2021. Managing software on
a heterogenous HPC cluster. ASHPC21 – Austrian-Slovenian HPC Meeting 2021. ASHPC
- Austrian-Slovenian HPC Meeting, 5.
mla: Schlögl, Alois, et al. “Managing Software on a Heterogenous HPC Cluster.” ASHPC21
– Austrian-Slovenian HPC Meeting 2021, University of Ljubljana, 2021, p. 5,
doi:10.3359/2021hpc.
short: A. Schlögl, S. Elefante, A. Hornoiu, S. Stadlbauer, in:, ASHPC21 – Austrian-Slovenian
HPC Meeting 2021, University of Ljubljana, 2021, p. 5.
conference:
end_date: 2021-06-02
location: Virtual
name: ASHPC - Austrian-Slovenian HPC Meeting
start_date: 2021-05-31
date_created: 2023-05-05T13:17:36Z
date_published: 2021-06-02T00:00:00Z
date_updated: 2023-05-16T07:43:54Z
day: '02'
ddc:
- '000'
department:
- _id: ScienComp
doi: 10.3359/2021hpc
file:
- access_level: open_access
checksum: ba73f85858fb9d5737ebc7724646dd45
content_type: application/pdf
creator: dernst
date_created: 2023-05-16T07:36:34Z
date_updated: 2023-05-16T07:36:34Z
file_id: '12971'
file_name: 2021_ASHPC_Schloegl.pdf
file_size: 422761
relation: main_file
success: 1
file_date_updated: 2023-05-16T07:36:34Z
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://vsc.ac.at/fileadmin/user_upload/vsc/conferences/ashpc21/BOOKLET_ASHPC21.pdf
month: '06'
oa: 1
oa_version: Published Version
page: '5'
publication: ASHPC21 – Austrian-Slovenian HPC Meeting 2021
publication_identifier:
isbn:
- 978-961-6980-77-7
- 978-961-6133-48-7
publication_status: published
publisher: University of Ljubljana
status: public
title: Managing software on a heterogenous HPC cluster
type: conference_abstract
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2021'
...
---
_id: '12987'
abstract:
- lang: eng
text: Chromosomal inversion polymorphisms, segments of chromosomes that are flipped
in orientation and occur in reversed order in some individuals, have long been
recognized to play an important role in local adaptation. They can reduce recombination
in heterozygous individuals and thus help to maintain sets of locally adapted
alleles. In a wide range of organisms, populations adapted to different habitats
differ in frequency of inversion arrangements. However, getting a full understanding
of the importance of inversions for adaptation requires confirmation of their
influence on traits under divergent selection. Here, we studied a marine snail,
Littorina saxatilis, that has evolved ecotypes adapted to wave exposure or crab
predation. These two types occur in close proximity on different parts of the
shore. Gene flow between them exists in contact zones. However, they exhibit strong
phenotypic divergence in several traits under habitat-specific selection, including
size, shape and behaviour. We used crosses between these ecotypes to identify
genomic regions that explain variation in these traits by using QTL analysis and
variance partitioning across linkage groups. We could show that previously detected
inversion regions contribute to adaptive divergence. Some inversions influenced
multiple traits suggesting that they contain sets of locally adaptive alleles.
Our study also identified regions without known inversions that are important
for phenotypic divergence. Thus, we provide a more complete overview of the importance
of inversions in relation to the remaining genome.
article_processing_charge: No
author:
- first_name: Eva
full_name: Koch, Eva
last_name: Koch
- first_name: Hernán E.
full_name: Morales, Hernán E.
last_name: Morales
- first_name: Jenny
full_name: Larsson, Jenny
last_name: Larsson
- first_name: Anja M
full_name: Westram, Anja M
id: 3C147470-F248-11E8-B48F-1D18A9856A87
last_name: Westram
orcid: 0000-0003-1050-4969
- first_name: Rui
full_name: Faria, Rui
last_name: Faria
- first_name: Alan R.
full_name: Lemmon, Alan R.
last_name: Lemmon
- first_name: E. Moriarty
full_name: Lemmon, E. Moriarty
last_name: Lemmon
- first_name: Kerstin
full_name: Johannesson, Kerstin
last_name: Johannesson
- first_name: Roger K.
full_name: Butlin, Roger K.
last_name: Butlin
citation:
ama: 'Koch E, Morales HE, Larsson J, et al. Data from: Genetic variation for adaptive
traits is associated with polymorphic inversions in Littorina saxatilis. 2021.
doi:10.5061/DRYAD.ZGMSBCCB4'
apa: 'Koch, E., Morales, H. E., Larsson, J., Westram, A. M., Faria, R., Lemmon,
A. R., … Butlin, R. K. (2021). Data from: Genetic variation for adaptive traits
is associated with polymorphic inversions in Littorina saxatilis. Dryad. https://doi.org/10.5061/DRYAD.ZGMSBCCB4'
chicago: 'Koch, Eva, Hernán E. Morales, Jenny Larsson, Anja M Westram, Rui Faria,
Alan R. Lemmon, E. Moriarty Lemmon, Kerstin Johannesson, and Roger K. Butlin.
“Data from: Genetic Variation for Adaptive Traits Is Associated with Polymorphic
Inversions in Littorina Saxatilis.” Dryad, 2021. https://doi.org/10.5061/DRYAD.ZGMSBCCB4.'
ieee: 'E. Koch et al., “Data from: Genetic variation for adaptive traits
is associated with polymorphic inversions in Littorina saxatilis.” Dryad, 2021.'
ista: 'Koch E, Morales HE, Larsson J, Westram AM, Faria R, Lemmon AR, Lemmon EM,
Johannesson K, Butlin RK. 2021. Data from: Genetic variation for adaptive traits
is associated with polymorphic inversions in Littorina saxatilis, Dryad, 10.5061/DRYAD.ZGMSBCCB4.'
mla: 'Koch, Eva, et al. Data from: Genetic Variation for Adaptive Traits Is Associated
with Polymorphic Inversions in Littorina Saxatilis. Dryad, 2021, doi:10.5061/DRYAD.ZGMSBCCB4.'
short: E. Koch, H.E. Morales, J. Larsson, A.M. Westram, R. Faria, A.R. Lemmon, E.M.
Lemmon, K. Johannesson, R.K. Butlin, (2021).
date_created: 2023-05-16T12:34:09Z
date_published: 2021-04-10T00:00:00Z
date_updated: 2023-08-08T13:34:07Z
day: '10'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.5061/DRYAD.ZGMSBCCB4
has_accepted_license: '1'
license: https://creativecommons.org/publicdomain/zero/1.0/
main_file_link:
- open_access: '1'
url: https://doi.org/10.5061/dryad.zgmsbccb4
month: '04'
oa: 1
oa_version: Published Version
publisher: Dryad
related_material:
record:
- id: '9394'
relation: used_in_publication
status: public
status: public
title: 'Data from: Genetic variation for adaptive traits is associated with polymorphic
inversions in Littorina saxatilis'
tmp:
image: /images/cc_0.png
legal_code_url: https://creativecommons.org/publicdomain/zero/1.0/legalcode
name: Creative Commons Public Domain Dedication (CC0 1.0)
short: CC0 (1.0)
type: research_data_reference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2021'
...
---
_id: '9728'
abstract:
- lang: eng
text: "Most real-world flows are multiphase, yet we know little about them compared
to their single-phase counterparts. Multiphase flows are more difficult to investigate
as their dynamics occur in large parameter space and involve complex phenomena
such as preferential concentration, turbulence modulation, non-Newtonian rheology,
etc. Over the last few decades, experiments in particle-laden flows have taken
a back seat in favour of ever-improving computational resources. However, computers
are still not powerful enough to simulate a real-world fluid with millions of
finite-size particles. Experiments are essential not only because they offer a
reliable way to investigate real-world multiphase flows but also because they
serve to validate numerical studies and steer the research in a relevant direction.
In this work, we have experimentally investigated particle-laden flows in pipes,
and in particular, examined the effect of particles on the laminar-turbulent transition
and the drag scaling in turbulent flows.\r\n\r\nFor particle-laden pipe flows,
an earlier study [Matas et al., 2003] reported how the sub-critical (i.e., hysteretic)
transition that occurs via localised turbulent structures called puffs is affected
by the addition of particles. In this study, in addition to this known transition,
we found a super-critical transition to a globally fluctuating state with increasing
particle concentration. At the same time, the Newtonian-type transition via puffs
is delayed to larger Reynolds numbers. At an even higher concentration, only the
globally fluctuating state is found. The dynamics of particle-laden flows are
hence determined by two competing instabilities that give rise to three flow regimes:
Newtonian-type turbulence at low, a particle-induced globally fluctuating state
at high, and a coexistence state at intermediate concentrations.\r\n\r\nThe effect
of particles on turbulent drag is ambiguous, with studies reporting drag reduction,
no net change, and even drag increase. The ambiguity arises because, in addition
to particle concentration, particle shape, size, and density also affect the net
drag. Even similar particles might affect the flow dissimilarly in different Reynolds
number and concentration ranges. In the present study, we explored a wide range
of both Reynolds number and concentration, using spherical as well as cylindrical
particles. We found that the spherical particles do not reduce drag while the
cylindrical particles are drag-reducing within a specific Reynolds number interval.
The interval strongly depends on the particle concentration and the relative size
of the pipe and particles. Within this interval, the magnitude of drag reduction
reaches a maximum. These drag reduction maxima appear to fall onto a distinct
power-law curve irrespective of the pipe diameter and particle concentration,
and this curve can be considered as the maximum drag reduction asymptote for a
given fibre shape. Such an asymptote is well known for polymeric flows but had
not been identified for particle-laden flows prior to this work."
acknowledged_ssus:
- _id: M-Shop
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Nishchal
full_name: Agrawal, Nishchal
id: 469E6004-F248-11E8-B48F-1D18A9856A87
last_name: Agrawal
citation:
ama: Agrawal N. Transition to turbulence and drag reduction in particle-laden pipe
flows. 2021. doi:10.15479/at:ista:9728
apa: Agrawal, N. (2021). Transition to turbulence and drag reduction in particle-laden
pipe flows. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:9728
chicago: Agrawal, Nishchal. “Transition to Turbulence and Drag Reduction in Particle-Laden
Pipe Flows.” Institute of Science and Technology Austria, 2021. https://doi.org/10.15479/at:ista:9728.
ieee: N. Agrawal, “Transition to turbulence and drag reduction in particle-laden
pipe flows,” Institute of Science and Technology Austria, 2021.
ista: Agrawal N. 2021. Transition to turbulence and drag reduction in particle-laden
pipe flows. Institute of Science and Technology Austria.
mla: Agrawal, Nishchal. Transition to Turbulence and Drag Reduction in Particle-Laden
Pipe Flows. Institute of Science and Technology Austria, 2021, doi:10.15479/at:ista:9728.
short: N. Agrawal, Transition to Turbulence and Drag Reduction in Particle-Laden
Pipe Flows, Institute of Science and Technology Austria, 2021.
date_created: 2021-07-27T13:40:30Z
date_published: 2021-07-29T00:00:00Z
date_updated: 2024-02-28T13:14:39Z
day: '29'
ddc:
- '532'
degree_awarded: PhD
department:
- _id: GradSch
- _id: BjHo
doi: 10.15479/at:ista:9728
file:
- access_level: closed
checksum: 77436be3563a90435024307b1b5ee7e8
content_type: application/x-zip-compressed
creator: nagrawal
date_created: 2021-07-28T13:32:02Z
date_updated: 2022-07-29T22:30:05Z
embargo_to: open_access
file_id: '9744'
file_name: Transition to Turbulence and Drag Reduction in Particle-Laden Pipe Flows.zip
file_size: 22859658
relation: source_file
- access_level: open_access
checksum: 72a891d7daba85445c29b868c22575ed
content_type: application/pdf
creator: nagrawal
date_created: 2021-07-28T13:32:05Z
date_updated: 2022-07-29T22:30:05Z
embargo: 2022-07-28
file_id: '9745'
file_name: Transition to Turbulence and Drag Reduction in Particle-Laden Pipe Flows.pdf
file_size: 18658048
relation: main_file
file_date_updated: 2022-07-29T22:30:05Z
has_accepted_license: '1'
keyword:
- Drag Reduction
- Transition to Turbulence
- Multiphase Flows
- particle Laden Flows
- Complex Flows
- Experiments
- Fluid Dynamics
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: '118'
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '6189'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Björn
full_name: Hof, Björn
id: 3A374330-F248-11E8-B48F-1D18A9856A87
last_name: Hof
orcid: 0000-0003-2057-2754
title: Transition to turbulence and drag reduction in particle-laden pipe flows
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2021'
...
---
_id: '9733'
abstract:
- lang: eng
text: This thesis is the result of the research carried out by the author during
his PhD at IST Austria between 2017 and 2021. It mainly focuses on the Fröhlich
polaron model, specifically to its regime of strong coupling. This model, which
is rigorously introduced and discussed in the introduction, has been of great
interest in condensed matter physics and field theory for more than eighty years.
It is used to describe an electron interacting with the atoms of a solid material
(the strength of this interaction is modeled by the presence of a coupling constant
α in the Hamiltonian of the system). The particular regime examined here, which
is mathematically described by considering the limit α →∞, displays many interesting
features related to the emergence of classical behavior, which allows for a simplified
effective description of the system under analysis. The properties, the range
of validity and a quantitative analysis of the precision of such classical approximations
are the main object of the present work. We specify our investigation to the study
of the ground state energy of the system, its dynamics and its effective mass.
For each of these problems, we provide in the introduction an overview of the
previously known results and a detailed account of the original contributions
by the author.
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Dario
full_name: Feliciangeli, Dario
id: 41A639AA-F248-11E8-B48F-1D18A9856A87
last_name: Feliciangeli
orcid: 0000-0003-0754-8530
citation:
ama: Feliciangeli D. The polaron at strong coupling. 2021. doi:10.15479/at:ista:9733
apa: Feliciangeli, D. (2021). The polaron at strong coupling. Institute of
Science and Technology Austria. https://doi.org/10.15479/at:ista:9733
chicago: Feliciangeli, Dario. “The Polaron at Strong Coupling.” Institute of Science
and Technology Austria, 2021. https://doi.org/10.15479/at:ista:9733.
ieee: D. Feliciangeli, “The polaron at strong coupling,” Institute of Science and
Technology Austria, 2021.
ista: Feliciangeli D. 2021. The polaron at strong coupling. Institute of Science
and Technology Austria.
mla: Feliciangeli, Dario. The Polaron at Strong Coupling. Institute of Science
and Technology Austria, 2021, doi:10.15479/at:ista:9733.
short: D. Feliciangeli, The Polaron at Strong Coupling, Institute of Science and
Technology Austria, 2021.
date_created: 2021-07-27T15:48:30Z
date_published: 2021-08-20T00:00:00Z
date_updated: 2024-03-06T12:30:44Z
day: '20'
ddc:
- '515'
- '519'
- '539'
degree_awarded: PhD
department:
- _id: GradSch
- _id: RoSe
- _id: JaMa
doi: 10.15479/at:ista:9733
ec_funded: 1
file:
- access_level: open_access
checksum: e88bb8ca43948abe060eb2d2fa719881
content_type: application/pdf
creator: dfelicia
date_created: 2021-08-19T14:03:48Z
date_updated: 2021-09-06T09:28:56Z
file_id: '9944'
file_name: Thesis_FeliciangeliA.pdf
file_size: 1958710
relation: main_file
- access_level: closed
checksum: 72810843abee83705853505b3f8348aa
content_type: application/octet-stream
creator: dfelicia
date_created: 2021-08-19T14:06:35Z
date_updated: 2022-03-10T12:13:57Z
file_id: '9945'
file_name: thesis.7z
file_size: 3771669
relation: source_file
file_date_updated: 2022-03-10T12:13:57Z
has_accepted_license: '1'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nd/4.0/
month: '08'
oa: 1
oa_version: Published Version
page: '180'
project:
- _id: 256E75B8-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '716117'
name: Optimal Transport and Stochastic Dynamics
- _id: 25C6DC12-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '694227'
name: Analysis of quantum many-body systems
- _id: fc31cba2-9c52-11eb-aca3-ff467d239cd2
grant_number: F6504
name: Taming Complexity in Partial Differential Systems
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '9787'
relation: part_of_dissertation
status: public
- id: '9792'
relation: part_of_dissertation
status: public
- id: '9225'
relation: part_of_dissertation
status: public
- id: '9781'
relation: part_of_dissertation
status: public
- id: '9791'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
- first_name: Jan
full_name: Maas, Jan
id: 4C5696CE-F248-11E8-B48F-1D18A9856A87
last_name: Maas
orcid: 0000-0002-0845-1338
title: The polaron at strong coupling
tmp:
image: /image/cc_by_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nd/4.0/legalcode
name: Creative Commons Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0)
short: CC BY-ND (4.0)
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2021'
...
---
_id: '9746'
abstract:
- lang: eng
text: Evolutionary adaptation is a major source of antibiotic resistance in bacterial
pathogens. Evolution-informed therapy aims to constrain resistance by accounting
for bacterial evolvability. Sequential treatments with antibiotics that target
different bacterial processes were previously shown to limit adaptation through
genetic resistance trade-offs and negative hysteresis. Treatment with homogeneous
sets of antibiotics is generally viewed to be disadvantageous, as it should rapidly
lead to cross-resistance. We here challenged this assumption by determining the
evolutionary response of Pseudomonas aeruginosa to experimental sequential treatments
involving both heterogenous and homogeneous antibiotic sets. To our surprise,
we found that fast switching between only β-lactam antibiotics resulted in increased
extinction of bacterial populations. We demonstrate that extinction is favored
by low rates of spontaneous resistance emergence and low levels of spontaneous
cross-resistance among the antibiotics in sequence. The uncovered principles may
help to guide the optimized use of available antibiotics in highly potent, evolution-informed
treatment designs.
acknowledgement: We would like to thank Leif Tueffers and João Botelho for discussions
and suggestions as well as Kira Haas and Julia Bunk for technical support. We acknowledge
financial support from the German Science Foundation (grant SCHU 1415/12-2 to HS,
and funding under Germany’s Excellence Strategy EXC 2167–390884018 as well as the
Research Training Group 2501 TransEvo to HS and SN), the Max Planck Society (IMPRS
scholarship to AB; Max-Planck fellowship to HS), and the Leibniz Science Campus
Evolutionary Medicine of the Lung (EvoLUNG, to HS and SN). This work was further
supported by the German Science Foundation Research Infrastructure NGS_CC (project
407495230) as part of the Next Generation Sequencing Competence Network (project
423957469). NGS analyses were carried out at the Competence Centre for Genomic Analysis
Kiel (CCGA Kiel).
article_number: e68876
article_processing_charge: No
article_type: original
author:
- first_name: Aditi
full_name: Batra, Aditi
last_name: Batra
- first_name: Roderich
full_name: Römhild, Roderich
id: 68E56E44-62B0-11EA-B963-444F3DDC885E
last_name: Römhild
orcid: 0000-0001-9480-5261
- first_name: Emilie
full_name: Rousseau, Emilie
last_name: Rousseau
- first_name: Sören
full_name: Franzenburg, Sören
last_name: Franzenburg
- first_name: Stefan
full_name: Niemann, Stefan
last_name: Niemann
- first_name: Hinrich
full_name: Schulenburg, Hinrich
last_name: Schulenburg
citation:
ama: Batra A, Römhild R, Rousseau E, Franzenburg S, Niemann S, Schulenburg H. High
potency of sequential therapy with only beta-lactam antibiotics. eLife.
2021;10. doi:10.7554/elife.68876
apa: Batra, A., Römhild, R., Rousseau, E., Franzenburg, S., Niemann, S., & Schulenburg,
H. (2021). High potency of sequential therapy with only beta-lactam antibiotics.
ELife. eLife Sciences Publications. https://doi.org/10.7554/elife.68876
chicago: Batra, Aditi, Roderich Römhild, Emilie Rousseau, Sören Franzenburg, Stefan
Niemann, and Hinrich Schulenburg. “High Potency of Sequential Therapy with Only
Beta-Lactam Antibiotics.” ELife. eLife Sciences Publications, 2021. https://doi.org/10.7554/elife.68876.
ieee: A. Batra, R. Römhild, E. Rousseau, S. Franzenburg, S. Niemann, and H. Schulenburg,
“High potency of sequential therapy with only beta-lactam antibiotics,” eLife,
vol. 10. eLife Sciences Publications, 2021.
ista: Batra A, Römhild R, Rousseau E, Franzenburg S, Niemann S, Schulenburg H. 2021.
High potency of sequential therapy with only beta-lactam antibiotics. eLife. 10,
e68876.
mla: Batra, Aditi, et al. “High Potency of Sequential Therapy with Only Beta-Lactam
Antibiotics.” ELife, vol. 10, e68876, eLife Sciences Publications, 2021,
doi:10.7554/elife.68876.
short: A. Batra, R. Römhild, E. Rousseau, S. Franzenburg, S. Niemann, H. Schulenburg,
ELife 10 (2021).
date_created: 2021-07-28T13:36:57Z
date_published: 2021-07-28T00:00:00Z
date_updated: 2023-08-11T10:26:29Z
day: '28'
department:
- _id: CaGu
doi: 10.7554/elife.68876
external_id:
isi:
- '000692027800001'
pmid:
- '34318749'
intvolume: ' 10'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.7554/eLife.68876
month: '07'
oa: 1
oa_version: Published Version
pmid: 1
publication: eLife
publication_identifier:
eissn:
- 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: High potency of sequential therapy with only beta-lactam antibiotics
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 10
year: '2021'
...
---
_id: '9756'
abstract:
- lang: eng
text: High-resolution visualization and quantification of membrane proteins contribute
to the understanding of their functions and the roles they play in physiological
and pathological conditions. Sodium dodecyl sulfate-digested freeze-fracture replica
labeling (SDS-FRL) is a powerful electron microscopy method to study quantitatively
the two-dimensional distribution of transmembrane proteins and their tightly associated
proteins. During treatment with SDS, intracellular organelles and proteins not
anchored to the replica are dissolved, whereas integral membrane proteins captured
and stabilized by carbon/platinum deposition remain on the replica. Their intra-
and extracellular domains become exposed on the surface of the replica, facilitating
the accessibility of antibodies and, therefore, providing higher labeling efficiency
than those obtained with other immunoelectron microscopy techniques. In this chapter,
we describe the protocols of SDS-FRL adapted for mammalian brain samples, and
optimization of the SDS treatment to increase the labeling efficiency for quantification
of Cav2.1, the alpha subunit of P/Q-type voltage-dependent calcium channels utilizing
deep learning algorithms.
acknowledgement: This work was supported by the European Union (European Research
Council Advanced grant no. 694539 and Human Brain Project Ref. 720270 to R. S.)
and the Austrian Academy of Sciences (DOC fellowship to D.K.).
alternative_title:
- Neuromethods
article_processing_charge: No
author:
- first_name: Walter
full_name: Kaufmann, Walter
id: 3F99E422-F248-11E8-B48F-1D18A9856A87
last_name: Kaufmann
orcid: 0000-0001-9735-5315
- first_name: David
full_name: Kleindienst, David
id: 42E121A4-F248-11E8-B48F-1D18A9856A87
last_name: Kleindienst
- first_name: Harumi
full_name: Harada, Harumi
id: 2E55CDF2-F248-11E8-B48F-1D18A9856A87
last_name: Harada
orcid: 0000-0001-7429-7896
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
citation:
ama: 'Kaufmann W, Kleindienst D, Harada H, Shigemoto R. High-Resolution localization
and quantitation of membrane proteins by SDS-digested freeze-fracture replica
labeling (SDS-FRL). In: Receptor and Ion Channel Detection in the Brain.
Vol 169. Neuromethods. New York: Humana; 2021:267-283. doi:10.1007/978-1-0716-1522-5_19'
apa: 'Kaufmann, W., Kleindienst, D., Harada, H., & Shigemoto, R. (2021). High-Resolution
localization and quantitation of membrane proteins by SDS-digested freeze-fracture
replica labeling (SDS-FRL). In Receptor and Ion Channel Detection in the Brain
(Vol. 169, pp. 267–283). New York: Humana. https://doi.org/10.1007/978-1-0716-1522-5_19'
chicago: 'Kaufmann, Walter, David Kleindienst, Harumi Harada, and Ryuichi Shigemoto.
“High-Resolution Localization and Quantitation of Membrane Proteins by SDS-Digested
Freeze-Fracture Replica Labeling (SDS-FRL).” In Receptor and Ion Channel Detection
in the Brain, 169:267–83. Neuromethods. New York: Humana, 2021. https://doi.org/10.1007/978-1-0716-1522-5_19.'
ieee: 'W. Kaufmann, D. Kleindienst, H. Harada, and R. Shigemoto, “High-Resolution
localization and quantitation of membrane proteins by SDS-digested freeze-fracture
replica labeling (SDS-FRL),” in Receptor and Ion Channel Detection in the
Brain, vol. 169, New York: Humana, 2021, pp. 267–283.'
ista: 'Kaufmann W, Kleindienst D, Harada H, Shigemoto R. 2021.High-Resolution localization
and quantitation of membrane proteins by SDS-digested freeze-fracture replica
labeling (SDS-FRL). In: Receptor and Ion Channel Detection in the Brain. Neuromethods,
vol. 169, 267–283.'
mla: Kaufmann, Walter, et al. “High-Resolution Localization and Quantitation of
Membrane Proteins by SDS-Digested Freeze-Fracture Replica Labeling (SDS-FRL).”
Receptor and Ion Channel Detection in the Brain, vol. 169, Humana, 2021,
pp. 267–83, doi:10.1007/978-1-0716-1522-5_19.
short: W. Kaufmann, D. Kleindienst, H. Harada, R. Shigemoto, in:, Receptor and
Ion Channel Detection in the Brain, Humana, New York, 2021, pp. 267–283.
date_created: 2021-07-30T09:34:56Z
date_published: 2021-07-27T00:00:00Z
date_updated: 2024-03-25T23:30:16Z
day: '27'
ddc:
- '573'
department:
- _id: RySh
- _id: EM-Fac
doi: 10.1007/978-1-0716-1522-5_19
ec_funded: 1
has_accepted_license: '1'
intvolume: ' 169'
keyword:
- 'Freeze-fracture replica: Deep learning'
- Immunogold labeling
- Integral membrane protein
- Electron microscopy
language:
- iso: eng
month: '07'
oa_version: None
page: 267-283
place: New York
project:
- _id: 25CA28EA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '694539'
name: 'In situ analysis of single channel subunit composition in neurons: physiological
implication in synaptic plasticity and behaviour'
- _id: 25CBA828-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '720270'
name: Human Brain Project Specific Grant Agreement 1 (HBP SGA 1)
publication: ' Receptor and Ion Channel Detection in the Brain'
publication_identifier:
eisbn:
- '9781071615225'
isbn:
- '9781071615218'
publication_status: published
publisher: Humana
quality_controlled: '1'
related_material:
record:
- id: '9562'
relation: dissertation_contains
status: public
series_title: Neuromethods
status: public
title: High-Resolution localization and quantitation of membrane proteins by SDS-digested
freeze-fracture replica labeling (SDS-FRL)
type: book_chapter
user_id: D865714E-FA4E-11E9-B85B-F5C5E5697425
volume: 169
year: '2021'
...
---
_id: '9759'
acknowledgement: The authors thank Inez Lam of Johns Hopkins University for valuable
comments on an earlier version of the manuscript. We also thank the facilitators
of the 2019–2020 eLife Community Ambassador program.
article_number: e1009124
article_processing_charge: Yes
article_type: letter_note
author:
- first_name: Michael John
full_name: Bartlett, Michael John
last_name: Bartlett
- first_name: Feyza N
full_name: Arslan, Feyza N
id: 49DA7910-F248-11E8-B48F-1D18A9856A87
last_name: Arslan
orcid: 0000-0001-5809-9566
- first_name: Adriana
full_name: Bankston, Adriana
last_name: Bankston
- first_name: Sarvenaz
full_name: Sarabipour, Sarvenaz
last_name: Sarabipour
citation:
ama: Bartlett MJ, Arslan FN, Bankston A, Sarabipour S. Ten simple rules to improve
academic work- life balance. PLoS Computational Biology. 2021;17(7). doi:10.1371/journal.pcbi.1009124
apa: Bartlett, M. J., Arslan, F. N., Bankston, A., & Sarabipour, S. (2021).
Ten simple rules to improve academic work- life balance. PLoS Computational
Biology. Public Library of Science. https://doi.org/10.1371/journal.pcbi.1009124
chicago: Bartlett, Michael John, Feyza N Arslan, Adriana Bankston, and Sarvenaz
Sarabipour. “Ten Simple Rules to Improve Academic Work- Life Balance.” PLoS
Computational Biology. Public Library of Science, 2021. https://doi.org/10.1371/journal.pcbi.1009124.
ieee: M. J. Bartlett, F. N. Arslan, A. Bankston, and S. Sarabipour, “Ten simple
rules to improve academic work- life balance,” PLoS Computational Biology,
vol. 17, no. 7. Public Library of Science, 2021.
ista: Bartlett MJ, Arslan FN, Bankston A, Sarabipour S. 2021. Ten simple rules to
improve academic work- life balance. PLoS Computational Biology. 17(7), e1009124.
mla: Bartlett, Michael John, et al. “Ten Simple Rules to Improve Academic Work-
Life Balance.” PLoS Computational Biology, vol. 17, no. 7, e1009124, Public
Library of Science, 2021, doi:10.1371/journal.pcbi.1009124.
short: M.J. Bartlett, F.N. Arslan, A. Bankston, S. Sarabipour, PLoS Computational
Biology 17 (2021).
date_created: 2021-08-01T22:01:21Z
date_published: 2021-07-15T00:00:00Z
date_updated: 2023-08-10T14:16:46Z
day: '15'
ddc:
- '613'
department:
- _id: CaHe
doi: 10.1371/journal.pcbi.1009124
external_id:
isi:
- '000677713500008'
pmid:
- '34264932'
file:
- access_level: open_access
checksum: e56d91f0eeadb36f143a90e2c1b3ab63
content_type: application/pdf
creator: cchlebak
date_created: 2021-08-05T12:06:49Z
date_updated: 2021-08-05T12:06:49Z
file_id: '9771'
file_name: 2021_PlosCompBio_Bartlett.pdf
file_size: 693633
relation: main_file
file_date_updated: 2021-08-05T12:06:49Z
has_accepted_license: '1'
intvolume: ' 17'
isi: 1
issue: '7'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
pmid: 1
publication: PLoS Computational Biology
publication_identifier:
eissn:
- '15537358'
issn:
- 1553734X
publication_status: published
publisher: Public Library of Science
scopus_import: '1'
status: public
title: Ten simple rules to improve academic work- life balance
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 17
year: '2021'
...
---
_id: '9760'
abstract:
- lang: eng
text: "The quantum approximate optimization algorithm (QAOA) is a prospective near-term
quantum algorithm due to its modest circuit depth and promising benchmarks. However,
an external parameter optimization required in the QAOA could become a performance
bottleneck. This motivates studies of the optimization landscape and search for
heuristic ways of parameter initialization. In this work we visualize the optimization
landscape of the QAOA applied to the MaxCut problem on random graphs, demonstrating
that random initialization of the QAOA is prone to converging to local minima
with suboptimal performance. We introduce the initialization of QAOA parameters
based on the Trotterized quantum annealing (TQA) protocol, parameterized by the
Trotter time step. We find that the TQA initialization allows to circumvent\r\nthe
issue of false minima for a broad range of time steps, yielding the same performance
as the best result out of an exponentially scaling number of random initializations.
Moreover, we demonstrate that the optimal value of the time step coincides with
the point of proliferation of Trotter errors in quantum annealing. Our results
suggest practical ways of initializing QAOA protocols on near-term quantum devices
and reveal new connections between QAOA and quantum annealing."
acknowledgement: We would like to thank D. Abanin and R. Medina for fruitful discussions
and A. Smith and I. Kim for valuable feedback on the manuscript. We acknowledge
support by the European Research Council (ERC) under the European Union’s Horizon
2020 research and innovation program (Grant Agreement No. 850899).
article_number: '491'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Stefan
full_name: Sack, Stefan
id: dd622248-f6e0-11ea-865d-ce382a1c81a5
last_name: Sack
orcid: 0000-0001-5400-8508
- first_name: Maksym
full_name: Serbyn, Maksym
id: 47809E7E-F248-11E8-B48F-1D18A9856A87
last_name: Serbyn
orcid: 0000-0002-2399-5827
citation:
ama: Sack S, Serbyn M. Quantum annealing initialization of the quantum approximate
optimization algorithm. Quantum. 2021;5. doi:10.22331/Q-2021-07-01-491
apa: Sack, S., & Serbyn, M. (2021). Quantum annealing initialization of the
quantum approximate optimization algorithm. Quantum. Verein zur Förderung
des Open Access Publizierens in den Quantenwissenschaften. https://doi.org/10.22331/Q-2021-07-01-491
chicago: Sack, Stefan, and Maksym Serbyn. “Quantum Annealing Initialization of the
Quantum Approximate Optimization Algorithm.” Quantum. Verein zur Förderung
des Open Access Publizierens in den Quantenwissenschaften, 2021. https://doi.org/10.22331/Q-2021-07-01-491.
ieee: S. Sack and M. Serbyn, “Quantum annealing initialization of the quantum approximate
optimization algorithm,” Quantum, vol. 5. Verein zur Förderung des Open
Access Publizierens in den Quantenwissenschaften, 2021.
ista: Sack S, Serbyn M. 2021. Quantum annealing initialization of the quantum approximate
optimization algorithm. Quantum. 5, 491.
mla: Sack, Stefan, and Maksym Serbyn. “Quantum Annealing Initialization of the Quantum
Approximate Optimization Algorithm.” Quantum, vol. 5, 491, Verein zur Förderung
des Open Access Publizierens in den Quantenwissenschaften, 2021, doi:10.22331/Q-2021-07-01-491.
short: S. Sack, M. Serbyn, Quantum 5 (2021).
date_created: 2021-08-01T22:01:21Z
date_published: 2021-07-01T00:00:00Z
date_updated: 2023-12-13T14:47:25Z
day: '01'
ddc:
- '530'
department:
- _id: GradSch
- _id: MaSe
doi: 10.22331/Q-2021-07-01-491
ec_funded: 1
external_id:
arxiv:
- '2101.05742'
isi:
- '000669830600001'
file:
- access_level: open_access
checksum: 9706c2bb8e748e9b5b138381995a7f6f
content_type: application/pdf
creator: cchlebak
date_created: 2021-08-06T06:44:31Z
date_updated: 2021-08-06T06:44:31Z
file_id: '9774'
file_name: 2021_Quantum_Sack.pdf
file_size: 2312482
relation: main_file
file_date_updated: 2021-08-06T06:44:31Z
has_accepted_license: '1'
intvolume: ' 5'
isi: 1
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
project:
- _id: 23841C26-32DE-11EA-91FC-C7463DDC885E
call_identifier: H2020
grant_number: '850899'
name: 'Non-Ergodic Quantum Matter: Universality, Dynamics and Control'
publication: Quantum
publication_identifier:
eissn:
- 2521-327X
publication_status: published
publisher: Verein zur Förderung des Open Access Publizierens in den Quantenwissenschaften
quality_controlled: '1'
related_material:
record:
- id: '14622'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Quantum annealing initialization of the quantum approximate optimization algorithm
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5
year: '2021'
...
---
_id: '9761'
abstract:
- lang: eng
text: 'The important roles of mitochondrial function and dysfunction in the process
of neurodegeneration are widely acknowledged. Retinal ganglion cells (RGCs) appear
to be a highly vulnerable neuronal cell type in the central nervous system with
respect to mitochondrial dysfunction but the actual reasons for this are still
incompletely understood. These cells have a unique circumstance where unmyelinated
axons must bend nearly 90° to exit the eye and then cross a translaminar pressure
gradient before becoming myelinated in the optic nerve. This region, the optic
nerve head, contains some of the highest density of mitochondria present in these
cells. Glaucoma represents a perfect storm of events occurring at this location,
with a combination of changes in the translaminar pressure gradient and reassignment
of the metabolic support functions of supporting glia, which appears to apply
increased metabolic stress to the RGC axons leading to a failure of axonal transport
mechanisms. However, RGCs themselves are also extremely sensitive to genetic mutations,
particularly in genes affecting mitochondrial dynamics and mitochondrial clearance.
These mutations, which systemically affect the mitochondria in every cell, often
lead to an optic neuropathy as the sole pathologic defect in affected patients.
This review summarizes knowledge of mitochondrial structure and function, the
known energy demands of neurons in general, and places these in the context of
normal and pathological characteristics of mitochondria attributed to RGCs. '
acknowledgement: The authors are grateful to Kazuya Oikawa and Gillian McLellan for
generously sharing some of their data for this review, and to Janis Eells for helpful
comments on the manuscript.
article_number: '1593'
article_processing_charge: Yes
article_type: original
author:
- first_name: Nicole A.
full_name: Muench, Nicole A.
last_name: Muench
- first_name: Sonia
full_name: Patel, Sonia
last_name: Patel
- first_name: Margaret E
full_name: Maes, Margaret E
id: 3838F452-F248-11E8-B48F-1D18A9856A87
last_name: Maes
orcid: 0000-0001-9642-1085
- first_name: Ryan J.
full_name: Donahue, Ryan J.
last_name: Donahue
- first_name: Akihiro
full_name: Ikeda, Akihiro
last_name: Ikeda
- first_name: Robert W.
full_name: Nickells, Robert W.
last_name: Nickells
citation:
ama: Muench NA, Patel S, Maes ME, Donahue RJ, Ikeda A, Nickells RW. The influence
of mitochondrial dynamics and function on retinal ganglion cell susceptibility
in optic nerve disease. Cells. 2021;10(7). doi:10.3390/cells10071593
apa: Muench, N. A., Patel, S., Maes, M. E., Donahue, R. J., Ikeda, A., & Nickells,
R. W. (2021). The influence of mitochondrial dynamics and function on retinal
ganglion cell susceptibility in optic nerve disease. Cells. MDPI. https://doi.org/10.3390/cells10071593
chicago: Muench, Nicole A., Sonia Patel, Margaret E Maes, Ryan J. Donahue, Akihiro
Ikeda, and Robert W. Nickells. “The Influence of Mitochondrial Dynamics and Function
on Retinal Ganglion Cell Susceptibility in Optic Nerve Disease.” Cells.
MDPI, 2021. https://doi.org/10.3390/cells10071593.
ieee: N. A. Muench, S. Patel, M. E. Maes, R. J. Donahue, A. Ikeda, and R. W. Nickells,
“The influence of mitochondrial dynamics and function on retinal ganglion cell
susceptibility in optic nerve disease,” Cells, vol. 10, no. 7. MDPI, 2021.
ista: Muench NA, Patel S, Maes ME, Donahue RJ, Ikeda A, Nickells RW. 2021. The influence
of mitochondrial dynamics and function on retinal ganglion cell susceptibility
in optic nerve disease. Cells. 10(7), 1593.
mla: Muench, Nicole A., et al. “The Influence of Mitochondrial Dynamics and Function
on Retinal Ganglion Cell Susceptibility in Optic Nerve Disease.” Cells,
vol. 10, no. 7, 1593, MDPI, 2021, doi:10.3390/cells10071593.
short: N.A. Muench, S. Patel, M.E. Maes, R.J. Donahue, A. Ikeda, R.W. Nickells,
Cells 10 (2021).
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title: The influence of mitochondrial dynamics and function on retinal ganglion cell
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