[{"isi":1,"date_updated":"2024-03-25T23:30:22Z","volume":87,"date_created":"2018-12-11T11:44:20Z","abstract":[{"text":"Plant hormones as signalling molecules play an essential role in the control of plant growth and development. Typically, sites of hormonal action are usually distant from the site of biosynthesis thus relying on efficient transport mechanisms. Over the last decades, molecular identification of proteins and protein complexes involved in hormonal transport has started. Advanced screens for genes involved in hormonal transport in combination with transport assays using heterologous systems such as yeast, insect, or tobacco BY2 cells or Xenopus oocytes provided important insights into mechanisms underlying distribution of hormones in plant body and led to identification of principal transporters for each hormone. This review gives a short overview of the mechanisms of hormonal transport and transporters identified in Arabidopsis thaliana.","lang":"eng"}],"language":[{"iso":"eng"}],"department":[{"_id":"EvBe"}],"publisher":"Elsevier","_id":"47","day":"01","citation":{"ieee":"R. Abualia, E. Benková, and B. Lacombe, “Transporters and mechanisms of hormone transport in arabidopsis,” <i>Advances in Botanical Research</i>, vol. 87. Elsevier, pp. 115–138, 2018.","ista":"Abualia R, Benková E, Lacombe B. 2018. Transporters and mechanisms of hormone transport in arabidopsis. Advances in Botanical Research. 87, 115–138.","mla":"Abualia, Rashed, et al. “Transporters and Mechanisms of Hormone Transport in Arabidopsis.” <i>Advances in Botanical Research</i>, vol. 87, Elsevier, 2018, pp. 115–38, doi:<a href=\"https://doi.org/10.1016/bs.abr.2018.09.007\">10.1016/bs.abr.2018.09.007</a>.","chicago":"Abualia, Rashed, Eva Benková, and Benoît Lacombe. “Transporters and Mechanisms of Hormone Transport in Arabidopsis.” <i>Advances in Botanical Research</i>. Elsevier, 2018. <a href=\"https://doi.org/10.1016/bs.abr.2018.09.007\">https://doi.org/10.1016/bs.abr.2018.09.007</a>.","short":"R. Abualia, E. Benková, B. Lacombe, Advances in Botanical Research 87 (2018) 115–138.","ama":"Abualia R, Benková E, Lacombe B. Transporters and mechanisms of hormone transport in arabidopsis. <i>Advances in Botanical Research</i>. 2018;87:115-138. doi:<a href=\"https://doi.org/10.1016/bs.abr.2018.09.007\">10.1016/bs.abr.2018.09.007</a>","apa":"Abualia, R., Benková, E., &#38; Lacombe, B. (2018). Transporters and mechanisms of hormone transport in arabidopsis. <i>Advances in Botanical Research</i>. Elsevier. <a href=\"https://doi.org/10.1016/bs.abr.2018.09.007\">https://doi.org/10.1016/bs.abr.2018.09.007</a>"},"page":"115 - 138","title":"Transporters and mechanisms of hormone transport in arabidopsis","status":"public","scopus_import":"1","publist_id":"8007","type":"journal_article","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","date_published":"2018-01-01T00:00:00Z","publication":"Advances in Botanical Research","external_id":{"isi":["000453657800006"]},"quality_controlled":"1","intvolume":"        87","author":[{"last_name":"Abualia","id":"4827E134-F248-11E8-B48F-1D18A9856A87","full_name":"Abualia, Rashed","orcid":"0000-0002-9357-9415","first_name":"Rashed"},{"orcid":"0000-0002-8510-9739","first_name":"Eva","full_name":"Benková, Eva","id":"38F4F166-F248-11E8-B48F-1D18A9856A87","last_name":"Benková"},{"first_name":"Benoît","full_name":"Lacombe, Benoît","last_name":"Lacombe"}],"month":"01","year":"2018","doi":"10.1016/bs.abr.2018.09.007","related_material":{"record":[{"relation":"dissertation_contains","status":"public","id":"10303"}]},"oa_version":"None","publication_status":"published","article_processing_charge":"No"},{"ddc":["573"],"doi":"10.15479/AT:ISTA:th_1042","has_accepted_license":"1","file":[{"embargo_to":"open_access","checksum":"7db4415e435590fa33542c7b0a0321d7","file_size":7666687,"file_id":"6236","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","date_updated":"2021-02-11T23:30:22Z","relation":"source_file","access_level":"closed","creator":"dernst","file_name":"2018_Thesis_Gridchyn_source.docx","date_created":"2019-04-08T13:36:01Z"},{"access_level":"open_access","creator":"dernst","file_name":"2018_Thesis_Gridchyn.pdf","date_created":"2019-04-08T13:36:01Z","date_updated":"2021-02-11T11:17:18Z","file_id":"6237","content_type":"application/pdf","embargo":"2019-08-29","relation":"main_file","file_size":6034153,"checksum":"f96f3fe8979f7b1e6db6acaca962b10c"}],"year":"2018","supervisor":[{"orcid":"0000-0002-5193-4036","full_name":"Csicsvari, Jozsef L","first_name":"Jozsef L","id":"3FA14672-F248-11E8-B48F-1D18A9856A87","last_name":"Csicsvari"}],"article_processing_charge":"No","publication_status":"published","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"oa_version":"Published Version","date_published":"2018-08-27T00:00:00Z","degree_awarded":"PhD","month":"08","author":[{"first_name":"Igor","orcid":"0000-0002-1807-1929","full_name":"Gridchyn, Igor","last_name":"Gridchyn","id":"4B60654C-F248-11E8-B48F-1D18A9856A87"}],"publist_id":"8006","type":"dissertation","page":"104","publication_identifier":{"issn":["2663-337X"]},"status":"public","title":"Reactivation content is important for consolidation of spatial memory","file_date_updated":"2021-02-11T23:30:22Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","license":"https://creativecommons.org/licenses/by/4.0/","language":[{"iso":"eng"}],"abstract":[{"text":"The hippocampus is a key brain region for spatial memory and navigation and is needed at all stages of memory, including encoding, consolidation, and recall. Hippocampal place cells selectively discharge at specific locations of the environment to form a cognitive map of the space. During the rest period and sleep following spatial navigation and/or learning, the waking activity of the place cells is reactivated within high synchrony events. This reactivation is thought to be important for memory consolidation and stabilization of the spatial representations. The aim of my thesis was to directly test whether the reactivation content encoded in firing patterns of place cells is important for consolidation of spatial memories. In particular, I aimed to test whether, in cases when multiple spatial memory traces are acquired during learning, the specific disruption of the reactivation of a subset of these memories leads to the selective disruption of the corresponding memory traces or through memory interference the other learned memories are disrupted as well. In this thesis, using a modified cheeseboard paradigm and a closed-loop recording setup with feedback optogenetic stimulation, I examined how the disruption of the reactivation of specific spiking patterns affects consolidation of the corresponding memory traces. To obtain multiple distinctive memories, animals had to perform a spatial task in two distinct cheeseboard environments and the reactivation of spiking patterns associated with one of the environments (target) was disrupted after learning during four hours rest period using a real-time decoding method. This real-time decoding method was capable of selectively affecting the firing rates and cofiring correlations of the target environment-encoding cells. The selective disruption led to behavioural impairment in the memory tests after the rest periods in the target environment but not in the other undisrupted control environment. In addition, the map of the target environment was less stable in the impaired memory tests compared to the learning session before than the map of the control environment. However, when the animal relearned the task, the same map recurred in the target environment that was present during learning before the disruption. Altogether my work demonstrated that the reactivation content is important: assembly-related disruption of reactivation can lead to a selective memory impairment and deficiency in map stability. These findings indeed suggest that reactivated assembly patterns reflect processes associated with the consolidation of memory traces. ","lang":"eng"}],"date_created":"2018-12-11T11:44:21Z","date_updated":"2023-09-07T12:42:44Z","oa":1,"citation":{"ista":"Gridchyn I. 2018. Reactivation content is important for consolidation of spatial memory. Institute of Science and Technology Austria.","chicago":"Gridchyn, Igor. “Reactivation Content Is Important for Consolidation of Spatial Memory.” Institute of Science and Technology Austria, 2018. <a href=\"https://doi.org/10.15479/AT:ISTA:th_1042\">https://doi.org/10.15479/AT:ISTA:th_1042</a>.","mla":"Gridchyn, Igor. <i>Reactivation Content Is Important for Consolidation of Spatial Memory</i>. Institute of Science and Technology Austria, 2018, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th_1042\">10.15479/AT:ISTA:th_1042</a>.","ieee":"I. Gridchyn, “Reactivation content is important for consolidation of spatial memory,” Institute of Science and Technology Austria, 2018.","short":"I. Gridchyn, Reactivation Content Is Important for Consolidation of Spatial Memory, Institute of Science and Technology Austria, 2018.","apa":"Gridchyn, I. (2018). <i>Reactivation content is important for consolidation of spatial memory</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:th_1042\">https://doi.org/10.15479/AT:ISTA:th_1042</a>","ama":"Gridchyn I. Reactivation content is important for consolidation of spatial memory. 2018. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th_1042\">10.15479/AT:ISTA:th_1042</a>"},"pubrep_id":"1042","_id":"48","publisher":"Institute of Science and Technology Austria","day":"27","alternative_title":["ISTA Thesis"],"department":[{"_id":"JoCs"}]},{"date_published":"2018-07-30T00:00:00Z","degree_awarded":"PhD","month":"07","author":[{"full_name":"Watzinger, Hannes","first_name":"Hannes","last_name":"Watzinger","id":"35DF8E50-F248-11E8-B48F-1D18A9856A87"}],"doi":"10.15479/AT:ISTA:th_1033","file":[{"relation":"main_file","content_type":"application/pdf","file_id":"6249","date_updated":"2020-07-14T12:46:35Z","file_name":"2018_Thesis_Watzinger.pdf","date_created":"2019-04-09T07:13:28Z","creator":"dernst","access_level":"open_access","checksum":"b653b5216251f938ddbeafd1de88667c","file_size":85539748},{"access_level":"closed","date_created":"2019-04-09T07:13:27Z","file_name":"2018_Thesis_Watzinger_source.zip","creator":"dernst","date_updated":"2020-07-14T12:46:35Z","content_type":"application/zip","file_id":"6250","relation":"source_file","checksum":"39bcf8de7ac5b1bb516b11ce2f966785","file_size":21830697}],"has_accepted_license":"1","year":"2018","supervisor":[{"full_name":"Katsaros, Georgios","orcid":"0000-0001-8342-202X","first_name":"Georgios","last_name":"Katsaros","id":"38DB5788-F248-11E8-B48F-1D18A9856A87"}],"ddc":["530"],"oa_version":"Published Version","article_processing_charge":"No","publication_status":"published","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"date_updated":"2023-09-07T12:27:43Z","oa":1,"language":[{"iso":"eng"}],"date_created":"2018-12-11T11:44:21Z","abstract":[{"lang":"eng","text":"Nowadays, quantum computation is receiving more and more attention as an alternative to the classical way of computing. For realizing a quantum computer, different devices are investigated as potential quantum bits. In this thesis, the focus is on Ge hut wires, which turned out to be promising candidates for implementing hole spin quantum bits. The advantages of Ge as a material system are the low hyperfine interaction for holes and the strong spin orbit coupling, as well as the compatibility with the highly developed CMOS processes in industry. In addition, Ge can also be isotopically purified which is expected to boost the spin coherence times. The strong spin orbit interaction for holes in Ge on the one hand enables the full electrical control of the quantum bit and on the other hand should allow short spin manipulation times. Starting with a bare Si wafer, this work covers the entire process reaching from growth over the fabrication and characterization of hut wire devices up to the demonstration of hole spin resonance. From experiments with single quantum dots, a large g-factor anisotropy between the in-plane and the out-of-plane direction was found. A comparison to a theoretical model unveiled the heavy-hole character of the lowest energy states. The second part of the thesis addresses double quantum dot devices, which were realized by adding two gate electrodes to a hut wire. In such devices, Pauli spin blockade was observed, which can serve as a read-out mechanism for spin quantum bits. Applying oscillating electric fields in spin blockade allowed the demonstration of continuous spin rotations and the extraction of a lower bound for the spin dephasing time. Despite the strong spin orbit coupling in Ge, the obtained value for the dephasing time is comparable to what has been recently reported for holes in Si. All in all, the presented results point out the high potential of Ge hut wires as a platform for long-lived, fast and fully electrically tunable hole spin quantum bits."}],"department":[{"_id":"GeKa"}],"alternative_title":["ISTA Thesis"],"citation":{"ama":"Watzinger H. Ge hut wires - from growth to hole spin resonance. 2018. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th_1033\">10.15479/AT:ISTA:th_1033</a>","apa":"Watzinger, H. (2018). <i>Ge hut wires - from growth to hole spin resonance</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:th_1033\">https://doi.org/10.15479/AT:ISTA:th_1033</a>","short":"H. Watzinger, Ge Hut Wires - from Growth to Hole Spin Resonance, Institute of Science and Technology Austria, 2018.","ieee":"H. Watzinger, “Ge hut wires - from growth to hole spin resonance,” Institute of Science and Technology Austria, 2018.","mla":"Watzinger, Hannes. <i>Ge Hut Wires - from Growth to Hole Spin Resonance</i>. Institute of Science and Technology Austria, 2018, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th_1033\">10.15479/AT:ISTA:th_1033</a>.","ista":"Watzinger H. 2018. Ge hut wires - from growth to hole spin resonance. Institute of Science and Technology Austria.","chicago":"Watzinger, Hannes. “Ge Hut Wires - from Growth to Hole Spin Resonance.” Institute of Science and Technology Austria, 2018. <a href=\"https://doi.org/10.15479/AT:ISTA:th_1033\">https://doi.org/10.15479/AT:ISTA:th_1033</a>."},"_id":"49","pubrep_id":"1033","publisher":"Institute of Science and Technology Austria","day":"30","publist_id":"8005","type":"dissertation","page":"77","status":"public","publication_identifier":{"issn":["2663-337X"]},"title":"Ge hut wires - from growth to hole spin resonance","file_date_updated":"2020-07-14T12:46:35Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1"},{"publication_status":"published","article_processing_charge":"No","oa_version":"Published Version","ddc":["570","591","596"],"related_material":{"record":[{"status":"public","relation":"part_of_dissertation","id":"1100"},{"status":"public","relation":"part_of_dissertation","id":"661"},{"id":"676","relation":"part_of_dissertation","status":"public"}]},"year":"2018","supervisor":[{"last_name":"Heisenberg","id":"39427864-F248-11E8-B48F-1D18A9856A87","first_name":"Carl-Philipp J","orcid":"0000-0002-0912-4566","full_name":"Heisenberg, Carl-Philipp J"}],"doi":"10.15479/AT:ISTA:TH_1031","has_accepted_license":"1","file":[{"file_size":31576521,"checksum":"d3eca3dcacb67bffdde6e6609c31cdd0","access_level":"open_access","file_name":"2018_Thesis_Capek.pdf","date_created":"2019-04-08T13:42:26Z","creator":"dernst","embargo":"2019-06-25","file_id":"6238","date_updated":"2021-02-11T11:17:17Z","content_type":"application/pdf","relation":"main_file"},{"content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","date_updated":"2021-02-11T23:30:21Z","file_id":"6239","relation":"source_file","access_level":"closed","date_created":"2019-04-08T13:42:27Z","file_name":"2018_Thesis_Capek_source.docx","creator":"dernst","embargo_to":"open_access","file_size":38992956,"checksum":"876deb14067e638aba65d209668bd821"}],"month":"06","author":[{"last_name":"Capek","id":"31C42484-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5199-9940","full_name":"Capek, Daniel","first_name":"Daniel"}],"date_published":"2018-06-22T00:00:00Z","degree_awarded":"PhD","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","file_date_updated":"2021-02-11T23:30:21Z","page":"95","title":"Optogenetic Frizzled 7 reveals a permissive function of Wnt/PCP signaling in directed mesenchymal cell migration","publication_identifier":{"issn":["2663-337X"]},"status":"public","publist_id":"8004","type":"dissertation","_id":"50","publisher":"Institute of Science and Technology Austria","pubrep_id":"1031","day":"22","citation":{"ama":"Capek D. Optogenetic Frizzled 7 reveals a permissive function of Wnt/PCP signaling in directed mesenchymal cell migration. 2018. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:TH_1031\">10.15479/AT:ISTA:TH_1031</a>","apa":"Capek, D. (2018). <i>Optogenetic Frizzled 7 reveals a permissive function of Wnt/PCP signaling in directed mesenchymal cell migration</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:TH_1031\">https://doi.org/10.15479/AT:ISTA:TH_1031</a>","short":"D. Capek, Optogenetic Frizzled 7 Reveals a Permissive Function of Wnt/PCP Signaling in Directed Mesenchymal Cell Migration, Institute of Science and Technology Austria, 2018.","ieee":"D. Capek, “Optogenetic Frizzled 7 reveals a permissive function of Wnt/PCP signaling in directed mesenchymal cell migration,” Institute of Science and Technology Austria, 2018.","chicago":"Capek, Daniel. “Optogenetic Frizzled 7 Reveals a Permissive Function of Wnt/PCP Signaling in Directed Mesenchymal Cell Migration.” Institute of Science and Technology Austria, 2018. <a href=\"https://doi.org/10.15479/AT:ISTA:TH_1031\">https://doi.org/10.15479/AT:ISTA:TH_1031</a>.","ista":"Capek D. 2018. Optogenetic Frizzled 7 reveals a permissive function of Wnt/PCP signaling in directed mesenchymal cell migration. Institute of Science and Technology Austria.","mla":"Capek, Daniel. <i>Optogenetic Frizzled 7 Reveals a Permissive Function of Wnt/PCP Signaling in Directed Mesenchymal Cell Migration</i>. Institute of Science and Technology Austria, 2018, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:TH_1031\">10.15479/AT:ISTA:TH_1031</a>."},"alternative_title":["ISTA Thesis"],"department":[{"_id":"CaHe"}],"abstract":[{"lang":"eng","text":"The Wnt/planar cell polarity (Wnt/PCP) pathway determines planar polarity of epithelial cells in both vertebrates and invertebrates. The role that Wnt/PCP signaling plays in mesenchymal contexts, however, is only poorly understood. While previous studies have demonstrated the capacity of Wnt/PCP signaling to polarize and guide directed migration of mesenchymal cells, it remains unclear whether endogenous Wnt/PCP signaling performs these functions instructively, as it does in epithelial cells. Here we developed a light-switchable version of the Wnt/PCP receptor Frizzled 7 (Fz7) to unambiguously distinguish between an instructive and a permissive role of Wnt/PCP signaling for the directional collective migration of mesendoderm progenitor cells during zebrafish gastrulation. We show that prechordal plate (ppl) cell migration is defective in maternal-zygotic fz7a and fz7b (MZ fz7a,b) double mutant embryos, and that Fz7 functions cell-autonomously in this process by promoting ppl cell protrusion formation and directed migration. We further show that local activation of Fz7 can direct ppl cell migration both in vitro and in vivo. Surprisingly, however, uniform Fz7 activation is sufficient to fully rescue the ppl cell migration defect in MZ fz7a,b mutant embryos, indicating that Wnt/PCP signaling functions permissively rather than instructively in directed mesendoderm cell migration during zebrafish gastrulation."}],"date_created":"2018-12-11T11:44:21Z","language":[{"iso":"eng"}],"oa":1,"date_updated":"2023-09-07T12:48:16Z"},{"date_published":"2018-02-20T00:00:00Z","publication":"Journal of Biotechnology","external_id":{"isi":["000425715100006"]},"acknowledgement":"We thank R Chait and M Lagator for sharing Bacillus subtilis CR_Y1 and pZS*_2R-cIPtet-Venus-Prm, respectively. We are grateful to T Pilizota and all members of the Guet lab for critically reading the manuscript. We also thank the Bioimaging facility at IST Austria for assistance using the FACSAria III system.\r\n\r\n","quality_controlled":"1","month":"02","author":[{"first_name":"Kathrin","full_name":"Tomasek, Kathrin","orcid":"0000-0003-3768-877X","last_name":"Tomasek","id":"3AEC8556-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Tobias","orcid":"0000-0001-5396-4346","full_name":"Bergmiller, Tobias","last_name":"Bergmiller","id":"2C471CFA-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Guet, Calin C","first_name":"Calin C","orcid":"0000-0001-6220-2052","id":"47F8433E-F248-11E8-B48F-1D18A9856A87","last_name":"Guet"}],"intvolume":"       268","year":"2018","doi":"10.1016/j.jbiotec.2018.01.008","oa_version":"None","publication_status":"published","article_processing_charge":"No","isi":1,"date_updated":"2023-09-13T08:24:51Z","abstract":[{"text":"Buffers are essential for diluting bacterial cultures for flow cytometry analysis in order to study bacterial physiology and gene expression parameters based on fluorescence signals. Using a variety of constitutively expressed fluorescent proteins in Escherichia coli K-12 strain MG1655, we found strong artifactual changes in fluorescence levels after dilution into the commonly used flow cytometry buffer phosphate-buffered saline (PBS) and two other buffer solutions, Tris-HCl and M9 salts. These changes appeared very rapidly after dilution, and were linked to increased membrane permeability and loss in cell viability. We observed buffer-related effects in several different E. coli strains, K-12, C and W, but not E. coli B, which can be partially explained by differences in lipopolysaccharide (LPS) and outer membrane composition. Supplementing the buffers with divalent cations responsible for outer membrane stability, Mg2+ and Ca2+, preserved fluorescence signals, membrane integrity and viability of E. coli. Thus, stabilizing the bacterial outer membrane is essential for precise and unbiased measurements of fluorescence parameters using flow cytometry.","lang":"eng"}],"volume":268,"date_created":"2018-12-11T11:46:50Z","language":[{"iso":"eng"}],"department":[{"_id":"CaGu"}],"day":"20","publisher":"Elsevier","_id":"503","citation":{"short":"K. Tomasek, T. Bergmiller, C.C. Guet, Journal of Biotechnology 268 (2018) 40–52.","ama":"Tomasek K, Bergmiller T, Guet CC. Lack of cations in flow cytometry buffers affect fluorescence signals by reducing membrane stability and viability of Escherichia coli strains. <i>Journal of Biotechnology</i>. 2018;268:40-52. doi:<a href=\"https://doi.org/10.1016/j.jbiotec.2018.01.008\">10.1016/j.jbiotec.2018.01.008</a>","apa":"Tomasek, K., Bergmiller, T., &#38; Guet, C. C. (2018). Lack of cations in flow cytometry buffers affect fluorescence signals by reducing membrane stability and viability of Escherichia coli strains. <i>Journal of Biotechnology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.jbiotec.2018.01.008\">https://doi.org/10.1016/j.jbiotec.2018.01.008</a>","ieee":"K. Tomasek, T. Bergmiller, and C. C. Guet, “Lack of cations in flow cytometry buffers affect fluorescence signals by reducing membrane stability and viability of Escherichia coli strains,” <i>Journal of Biotechnology</i>, vol. 268. Elsevier, pp. 40–52, 2018.","chicago":"Tomasek, Kathrin, Tobias Bergmiller, and Calin C Guet. “Lack of Cations in Flow Cytometry Buffers Affect Fluorescence Signals by Reducing Membrane Stability and Viability of Escherichia Coli Strains.” <i>Journal of Biotechnology</i>. Elsevier, 2018. <a href=\"https://doi.org/10.1016/j.jbiotec.2018.01.008\">https://doi.org/10.1016/j.jbiotec.2018.01.008</a>.","mla":"Tomasek, Kathrin, et al. “Lack of Cations in Flow Cytometry Buffers Affect Fluorescence Signals by Reducing Membrane Stability and Viability of Escherichia Coli Strains.” <i>Journal of Biotechnology</i>, vol. 268, Elsevier, 2018, pp. 40–52, doi:<a href=\"https://doi.org/10.1016/j.jbiotec.2018.01.008\">10.1016/j.jbiotec.2018.01.008</a>.","ista":"Tomasek K, Bergmiller T, Guet CC. 2018. Lack of cations in flow cytometry buffers affect fluorescence signals by reducing membrane stability and viability of Escherichia coli strains. Journal of Biotechnology. 268, 40–52."},"scopus_import":"1","title":"Lack of cations in flow cytometry buffers affect fluorescence signals by reducing membrane stability and viability of Escherichia coli strains","status":"public","page":"40 - 52","publist_id":"7317","type":"journal_article","acknowledged_ssus":[{"_id":"Bio"}],"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1"},{"doi":"10.15479/AT:ISTA:th_1032","file":[{"embargo_to":"open_access","file_size":141270528,"checksum":"dcc7b55619d8509dd62b8e99d6cdee44","relation":"source_file","content_type":"application/msword","file_id":"6251","date_updated":"2021-02-11T23:30:13Z","creator":"dernst","file_name":"2018_Thesis_Case_Source.doc","date_created":"2019-04-09T07:16:26Z","access_level":"closed"},{"access_level":"open_access","creator":"dernst","file_name":"2018_Thesis_Case.pdf","date_created":"2019-04-09T07:16:23Z","file_id":"6252","content_type":"application/pdf","date_updated":"2021-02-11T11:17:14Z","embargo":"2019-07-05","relation":"main_file","file_size":15193621,"checksum":"f69fdd5c8709c4e618aa8c1a1221153d"}],"has_accepted_license":"1","year":"2018","supervisor":[{"first_name":"Ryuichi","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto"}],"related_material":{"record":[{"id":"682","relation":"part_of_dissertation","status":"public"}]},"ddc":["571","576"],"oa_version":"Published Version","article_processing_charge":"No","publication_status":"published","date_published":"2018-06-27T00:00:00Z","degree_awarded":"PhD","author":[{"first_name":"Matthew J","full_name":"Case, Matthew J","id":"44B7CA5A-F248-11E8-B48F-1D18A9856A87","last_name":"Case"}],"month":"06","type":"dissertation","publist_id":"8003","page":"186","title":"From the left to the right: A tale of asymmetries, environments, and hippocampal development","status":"public","publication_identifier":{"issn":["2663-337X"]},"file_date_updated":"2021-02-11T23:30:13Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","date_updated":"2023-09-07T12:39:22Z","oa":1,"language":[{"iso":"eng"}],"date_created":"2018-12-11T11:44:22Z","abstract":[{"lang":"eng","text":"Asymmetries have long been known about in the central nervous system. From gross anatomical differences, such as the presence of the parapineal organ in only one hemisphere of the developing zebrafish, to more subtle differences in activity between both hemispheres, as seen in freely roaming animals or human participants under PET and fMRI imaging analysis. The presence of asymmetries has been demonstrated to have huge behavioural implications, with their disruption often leading to the generation of neurological disorders, memory problems, changes in personality, and in an organism's health and well-being. For my Ph.D. work I aimed to tackle two important avenues of research. The first being the process of input-side dependency in the hippocampus, with the goal of finding a key gene responsible for its development (Gene X). The second project was to do with experience-induced laterality formation in the hippocampus. Specifically, how laterality in the synapse density of the CA1 stratum radiatum (s.r.) could be induced purely through environmental enrichment. Through unilateral tracer injections into the CA3, I was able to selectively measure the properties of synapses within the CA1 and investigate how they differed based upon which hemisphere the presynaptic neurone originated. Having found the existence of a previously unreported reversed (left-isomerism) i.v. mutant, through morpholocal examination of labelled terminals in the CA1 s.r., I aimed to elucidate a key gene responsible for the process of left or right determination of inputs to the CA1 s.r.. This work relates to the previous finding of input-side dependent asymmetry in the wild-type rodent, where the origin of the projecting neurone to the CA1 will determine the morphology of a synapse, to a greater degree than the hemisphere in which the projection terminates. Using left- and right-isomerism i.v. mice, in combination with whole genome sequence analysis, I highlight Ena/VASP-like (Evl) as a potential target for Gene X. In relation to this topic, I also highlight my work in the recently published paper of how knockout of PirB can lead to a lack of input-side dependency in the murine hippocampus. For the second question, I show that the environmental enrichment paradigm will lead to an asymmetry in the synapse densities in the hippocampus of mice. I also highlight that the nature of the enrichment is of less consequence than the process of enrichment itself. I demonstrate that the CA3 region will dramatically alter its projection targets, in relation to environmental stimulation, with the asymmetry in synaptic density, caused by enrichment, relying heavily on commissural fibres. I also highlight the vital importance of input-side dependent asymmetry, as a necessary component of experience-dependent laterality formation in the CA1 s.r.. However, my results suggest that it isn't the only cause, as there appears to be a CA1 dependent mechanism also at play. Upon further investigation, I highlight the significant, and highly important, finding that the changes seen in the CA1 s.r. were predominantly caused through projections from the left-CA3, with the right-CA3 having less involvement in this mechanism."}],"alternative_title":["ISTA Thesis"],"department":[{"_id":"RySh"}],"citation":{"ama":"Case MJ. From the left to the right: A tale of asymmetries, environments, and hippocampal development. 2018. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th_1032\">10.15479/AT:ISTA:th_1032</a>","apa":"Case, M. J. (2018). <i>From the left to the right: A tale of asymmetries, environments, and hippocampal development</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:th_1032\">https://doi.org/10.15479/AT:ISTA:th_1032</a>","short":"M.J. Case, From the Left to the Right: A Tale of Asymmetries, Environments, and Hippocampal Development, Institute of Science and Technology Austria, 2018.","ieee":"M. J. Case, “From the left to the right: A tale of asymmetries, environments, and hippocampal development,” Institute of Science and Technology Austria, 2018.","ista":"Case MJ. 2018. From the left to the right: A tale of asymmetries, environments, and hippocampal development. Institute of Science and Technology Austria.","mla":"Case, Matthew J. <i>From the Left to the Right: A Tale of Asymmetries, Environments, and Hippocampal Development</i>. Institute of Science and Technology Austria, 2018, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th_1032\">10.15479/AT:ISTA:th_1032</a>.","chicago":"Case, Matthew J. “From the Left to the Right: A Tale of Asymmetries, Environments, and Hippocampal Development.” Institute of Science and Technology Austria, 2018. <a href=\"https://doi.org/10.15479/AT:ISTA:th_1032\">https://doi.org/10.15479/AT:ISTA:th_1032</a>."},"_id":"51","pubrep_id":"1032","publisher":"Institute of Science and Technology Austria","day":"27"},{"quality_controlled":"1","month":"04","author":[{"last_name":"Altmeyer","id":"2EE67FDC-F248-11E8-B48F-1D18A9856A87","first_name":"Sebastian","orcid":"0000-0001-5964-0203","full_name":"Altmeyer, Sebastian"}],"intvolume":"       452","date_published":"2018-04-15T00:00:00Z","publication":"Journal of Magnetism and Magnetic Materials","external_id":{"isi":["000425547700061"]},"acknowledgement":"S.Altmeyer is a Serra Húnter Fellow","oa_version":"Submitted Version","publication_status":"published","article_processing_charge":"No","year":"2018","has_accepted_license":"1","file":[{"relation":"main_file","date_updated":"2020-07-14T12:46:37Z","file_id":"7838","content_type":"application/pdf","creator":"dernst","file_name":"2018_Magnetism_Altmeyer.pdf","date_created":"2020-05-14T14:41:17Z","access_level":"open_access","file_size":17309535,"checksum":"431f5cd4a628d7ca21161f82b14ccb4f"}],"doi":"10.1016/j.jmmm.2017.12.073","ddc":["530"],"department":[{"_id":"BjHo"}],"day":"15","publisher":"Elsevier","_id":"519","citation":{"ieee":"S. Altmeyer, “Non-linear dynamics and alternating ‘flip’ solutions in ferrofluidic Taylor-Couette flow,” <i>Journal of Magnetism and Magnetic Materials</i>, vol. 452. Elsevier, pp. 427–441, 2018.","ista":"Altmeyer S. 2018. Non-linear dynamics and alternating ‘flip’ solutions in ferrofluidic Taylor-Couette flow. Journal of Magnetism and Magnetic Materials. 452, 427–441.","chicago":"Altmeyer, Sebastian. “Non-Linear Dynamics and Alternating ‘Flip’ Solutions in Ferrofluidic Taylor-Couette Flow.” <i>Journal of Magnetism and Magnetic Materials</i>. Elsevier, 2018. <a href=\"https://doi.org/10.1016/j.jmmm.2017.12.073\">https://doi.org/10.1016/j.jmmm.2017.12.073</a>.","mla":"Altmeyer, Sebastian. “Non-Linear Dynamics and Alternating ‘Flip’ Solutions in Ferrofluidic Taylor-Couette Flow.” <i>Journal of Magnetism and Magnetic Materials</i>, vol. 452, Elsevier, 2018, pp. 427–41, doi:<a href=\"https://doi.org/10.1016/j.jmmm.2017.12.073\">10.1016/j.jmmm.2017.12.073</a>.","short":"S. Altmeyer, Journal of Magnetism and Magnetic Materials 452 (2018) 427–441.","ama":"Altmeyer S. Non-linear dynamics and alternating ‘flip’ solutions in ferrofluidic Taylor-Couette flow. <i>Journal of Magnetism and Magnetic Materials</i>. 2018;452:427-441. doi:<a href=\"https://doi.org/10.1016/j.jmmm.2017.12.073\">10.1016/j.jmmm.2017.12.073</a>","apa":"Altmeyer, S. (2018). Non-linear dynamics and alternating ‘flip’ solutions in ferrofluidic Taylor-Couette flow. <i>Journal of Magnetism and Magnetic Materials</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.jmmm.2017.12.073\">https://doi.org/10.1016/j.jmmm.2017.12.073</a>"},"isi":1,"oa":1,"article_type":"original","date_updated":"2023-09-13T09:03:44Z","volume":452,"date_created":"2018-12-11T11:46:56Z","abstract":[{"text":"This study treats with the influence of a symmetry-breaking transversal magnetic field on the nonlinear dynamics of ferrofluidic Taylor-Couette flow – flow confined between two concentric independently rotating cylinders. We detected alternating ‘flip’ solutions which are flow states featuring typical characteristics of slow-fast-dynamics in dynamical systems. The flip corresponds to a temporal change in the axial wavenumber and we find them to appear either as pure 2-fold axisymmetric (due to the symmetry-breaking nature of the applied transversal magnetic field) or involving non-axisymmetric, helical modes in its interim solution. The latter ones show features of typical ribbon solutions. In any case the flip solutions have a preferential first axial wavenumber which corresponds to the more stable state (slow dynamics) and second axial wavenumber, corresponding to the short appearing more unstable state (fast dynamics). However, in both cases the flip time grows exponential with increasing the magnetic field strength before the flip solutions, living on 2-tori invariant manifolds, cease to exist, with lifetime going to infinity. Further we show that ferrofluidic flow turbulence differ from the classical, ordinary (usually at high Reynolds number) turbulence. The applied magnetic field hinders the free motion of ferrofluid partials and therefore smoothen typical turbulent quantities and features so that speaking of mildly chaotic dynamics seems to be a more appropriate expression for the observed motion. ","lang":"eng"}],"language":[{"iso":"eng"}],"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","file_date_updated":"2020-07-14T12:46:37Z","status":"public","title":"Non-linear dynamics and alternating ‘flip’ solutions in ferrofluidic Taylor-Couette flow","scopus_import":"1","page":"427 - 441","type":"journal_article","publist_id":"7297"},{"type":"dissertation","publist_id":"8002","publication_identifier":{"issn":["2663-337X"]},"status":"public","title":"Point interactions in systems of fermions","page":"115","file_date_updated":"2020-07-14T12:46:37Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","date_updated":"2023-09-27T12:34:14Z","oa":1,"language":[{"iso":"eng"}],"date_created":"2018-12-11T11:44:22Z","abstract":[{"lang":"eng","text":"In this thesis we will discuss systems of point interacting fermions, their stability and other spectral properties. Whereas for bosons a point interacting system is always unstable this ques- tion is more subtle for a gas of two species of fermions. In particular the answer depends on the mass ratio between these two species. Most of this work will be focused on the N + M model which consists of two species of fermions with N, M particles respectively which interact via point interactions. We will introduce this model using a formal limit and discuss the N + 1 system in more detail. In particular, we will show that for mass ratios above a critical one, which does not depend on the particle number, the N + 1 system is stable. In the context of this model we will prove rigorous versions of Tan relations which relate various quantities of the point-interacting model. By restricting the N + 1 system to a box we define a finite density model with point in- teractions. In the context of this system we will discuss the energy change when introducing a point-interacting impurity into a system of non-interacting fermions. We will see that this change in energy is bounded independently of the particle number and in particular the bound only depends on the density and the scattering length. As another special case of the N + M model we will show stability of the 2 + 2 model for mass ratios in an interval around one. Further we will investigate a different model of point interactions which was discussed before in the literature and which is, contrary to the N + M model, not given by a limiting procedure but is based on a Dirichlet form. We will show that this system behaves trivially in the thermodynamic limit, i.e. the free energy per particle is the same as the one of the non-interacting system."}],"department":[{"_id":"RoSe"}],"alternative_title":["ISTA Thesis"],"citation":{"mla":"Moser, Thomas. <i>Point Interactions in Systems of Fermions</i>. Institute of Science and Technology Austria, 2018, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th_1043\">10.15479/AT:ISTA:th_1043</a>.","ista":"Moser T. 2018. Point interactions in systems of fermions. Institute of Science and Technology Austria.","chicago":"Moser, Thomas. “Point Interactions in Systems of Fermions.” Institute of Science and Technology Austria, 2018. <a href=\"https://doi.org/10.15479/AT:ISTA:th_1043\">https://doi.org/10.15479/AT:ISTA:th_1043</a>.","ieee":"T. Moser, “Point interactions in systems of fermions,” Institute of Science and Technology Austria, 2018.","apa":"Moser, T. (2018). <i>Point interactions in systems of fermions</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:th_1043\">https://doi.org/10.15479/AT:ISTA:th_1043</a>","ama":"Moser T. Point interactions in systems of fermions. 2018. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th_1043\">10.15479/AT:ISTA:th_1043</a>","short":"T. Moser, Point Interactions in Systems of Fermions, Institute of Science and Technology Austria, 2018."},"day":"04","pubrep_id":"1043","_id":"52","publisher":"Institute of Science and Technology Austria","file":[{"access_level":"open_access","creator":"dernst","date_created":"2019-04-09T07:45:38Z","file_name":"2018_Thesis_Moser.pdf","file_id":"6256","date_updated":"2020-07-14T12:46:37Z","content_type":"application/pdf","relation":"main_file","checksum":"fbd8c747d148b468a21213b7cf175225","file_size":851164},{"date_updated":"2020-07-14T12:46:37Z","file_id":"6257","content_type":"application/zip","relation":"source_file","access_level":"closed","file_name":"2018_Thesis_Moser_Source.zip","date_created":"2019-04-09T07:45:38Z","creator":"dernst","checksum":"c28e16ecfc1126d3ce324ec96493c01e","file_size":1531516}],"has_accepted_license":"1","doi":"10.15479/AT:ISTA:th_1043","supervisor":[{"orcid":"0000-0002-6781-0521","full_name":"Seiringer, Robert","first_name":"Robert","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","last_name":"Seiringer"}],"year":"2018","related_material":{"record":[{"status":"public","relation":"part_of_dissertation","id":"5856"},{"status":"public","relation":"part_of_dissertation","id":"154"},{"id":"1198","status":"public","relation":"part_of_dissertation"},{"id":"741","relation":"part_of_dissertation","status":"public"}]},"ddc":["515","530","519"],"project":[{"name":"Structure of the Excitation Spectrum for Many-Body Quantum Systems","grant_number":"P27533_N27","call_identifier":"FWF","_id":"25C878CE-B435-11E9-9278-68D0E5697425"}],"oa_version":"Published Version","article_processing_charge":"No","publication_status":"published","degree_awarded":"PhD","date_published":"2018-09-04T00:00:00Z","month":"09","author":[{"first_name":"Thomas","full_name":"Moser, Thomas","id":"2B5FC9A4-F248-11E8-B48F-1D18A9856A87","last_name":"Moser"}]},{"author":[{"id":"406048EC-F248-11E8-B48F-1D18A9856A87","last_name":"Petritsch","orcid":"0000-0003-2724-4614","full_name":"Petritsch, Barbara","first_name":"Barbara"},{"first_name":"Jana","full_name":"Porsche, Jana","last_name":"Porsche","id":"3252EDC2-F248-11E8-B48F-1D18A9856A87"}],"intvolume":"        71","month":"10","date_published":"2018-10-01T00:00:00Z","publication":"VÖB Mitteilungen","oa_version":"Published Version","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"publication_status":"published","year":"2018","file":[{"file_size":509434,"checksum":"7ac61bade5f37db011ca435ebcf86797","creator":"dernst","file_name":"2018_VOEB_Petritsch.pdf","date_created":"2018-12-17T12:40:27Z","access_level":"open_access","relation":"main_file","file_id":"5702","date_updated":"2020-07-14T12:46:38Z","content_type":"application/pdf"}],"has_accepted_license":"1","doi":"10.31263/voebm.v71i1.1993","ddc":["020"],"department":[{"_id":"E-Lib"}],"day":"01","publisher":"Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare","_id":"53","citation":{"chicago":"Petritsch, Barbara, and Jana Porsche. “IST PubRep and IST DataRep: The Institutional Repositories at IST Austria.” <i>VÖB Mitteilungen</i>. Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare, 2018. <a href=\"https://doi.org/10.31263/voebm.v71i1.1993\">https://doi.org/10.31263/voebm.v71i1.1993</a>.","ista":"Petritsch B, Porsche J. 2018. IST PubRep and IST DataRep: the institutional repositories at IST Austria. VÖB Mitteilungen. 71(1), 199–206.","mla":"Petritsch, Barbara, and Jana Porsche. “IST PubRep and IST DataRep: The Institutional Repositories at IST Austria.” <i>VÖB Mitteilungen</i>, vol. 71, no. 1, Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare, 2018, pp. 199–206, doi:<a href=\"https://doi.org/10.31263/voebm.v71i1.1993\">10.31263/voebm.v71i1.1993</a>.","ieee":"B. Petritsch and J. Porsche, “IST PubRep and IST DataRep: the institutional repositories at IST Austria,” <i>VÖB Mitteilungen</i>, vol. 71, no. 1. Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare, pp. 199–206, 2018.","apa":"Petritsch, B., &#38; Porsche, J. (2018). IST PubRep and IST DataRep: the institutional repositories at IST Austria. <i>VÖB Mitteilungen</i>. Vereinigung Österreichischer Bibliothekarinnen und Bibliothekare. <a href=\"https://doi.org/10.31263/voebm.v71i1.1993\">https://doi.org/10.31263/voebm.v71i1.1993</a>","ama":"Petritsch B, Porsche J. IST PubRep and IST DataRep: the institutional repositories at IST Austria. <i>VÖB Mitteilungen</i>. 2018;71(1):199-206. doi:<a href=\"https://doi.org/10.31263/voebm.v71i1.1993\">10.31263/voebm.v71i1.1993</a>","short":"B. Petritsch, J. Porsche, VÖB Mitteilungen 71 (2018) 199–206."},"oa":1,"date_updated":"2021-01-12T08:01:26Z","date_created":"2018-12-11T11:44:22Z","volume":71,"abstract":[{"lang":"eng","text":"In 2013, a publication repository was implemented at IST Austria and 2015 after a thorough preparation phase a data repository was implemented - both based on the Open Source Software EPrints. In this text, designed as field report, we will reflect on our experiences with Open Source Software in general and specifically with EPrints regarding technical aspects but also regarding their characteristics of the user community. The second part is a pleading for including the end users in the process of implementation, adaption and evaluation."}],"language":[{"iso":"eng"}],"issue":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file_date_updated":"2020-07-14T12:46:38Z","status":"public","scopus_import":1,"title":"IST PubRep and IST DataRep: the institutional repositories at IST Austria","page":"199 - 206","type":"journal_article","publist_id":"8001"},{"date_created":"2018-12-11T11:46:59Z","abstract":[{"lang":"eng","text":"Inclusion–exclusion is an effective method for computing the volume of a union of measurable sets. We extend it to multiple coverings, proving short inclusion–exclusion formulas for the subset of Rn covered by at least k balls in a finite set. We implement two of the formulas in dimension n=3 and report on results obtained with our software."}],"volume":68,"language":[{"iso":"eng"}],"isi":1,"oa":1,"date_updated":"2023-09-13T08:59:00Z","day":"01","publisher":"Elsevier","_id":"530","citation":{"apa":"Edelsbrunner, H., &#38; Iglesias Ham, M. (2018). Multiple covers with balls I: Inclusion–exclusion. <i>Computational Geometry: Theory and Applications</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.comgeo.2017.06.014\">https://doi.org/10.1016/j.comgeo.2017.06.014</a>","ama":"Edelsbrunner H, Iglesias Ham M. Multiple covers with balls I: Inclusion–exclusion. <i>Computational Geometry: Theory and Applications</i>. 2018;68:119-133. doi:<a href=\"https://doi.org/10.1016/j.comgeo.2017.06.014\">10.1016/j.comgeo.2017.06.014</a>","short":"H. Edelsbrunner, M. Iglesias Ham, Computational Geometry: Theory and Applications 68 (2018) 119–133.","ista":"Edelsbrunner H, Iglesias Ham M. 2018. Multiple covers with balls I: Inclusion–exclusion. Computational Geometry: Theory and Applications. 68, 119–133.","chicago":"Edelsbrunner, Herbert, and Mabel Iglesias Ham. “Multiple Covers with Balls I: Inclusion–Exclusion.” <i>Computational Geometry: Theory and Applications</i>. Elsevier, 2018. <a href=\"https://doi.org/10.1016/j.comgeo.2017.06.014\">https://doi.org/10.1016/j.comgeo.2017.06.014</a>.","mla":"Edelsbrunner, Herbert, and Mabel Iglesias Ham. “Multiple Covers with Balls I: Inclusion–Exclusion.” <i>Computational Geometry: Theory and Applications</i>, vol. 68, Elsevier, 2018, pp. 119–33, doi:<a href=\"https://doi.org/10.1016/j.comgeo.2017.06.014\">10.1016/j.comgeo.2017.06.014</a>.","ieee":"H. Edelsbrunner and M. Iglesias Ham, “Multiple covers with balls I: Inclusion–exclusion,” <i>Computational Geometry: Theory and Applications</i>, vol. 68. Elsevier, pp. 119–133, 2018."},"department":[{"_id":"HeEd"}],"status":"public","title":"Multiple covers with balls I: Inclusion–exclusion","scopus_import":"1","page":"119 - 133","publist_id":"7289","type":"journal_article","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","ec_funded":1,"file_date_updated":"2020-07-14T12:46:38Z","date_published":"2018-03-01T00:00:00Z","external_id":{"isi":["000415778300010"]},"publication":"Computational Geometry: Theory and Applications","month":"03","author":[{"last_name":"Edelsbrunner","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","full_name":"Edelsbrunner, Herbert","orcid":"0000-0002-9823-6833","first_name":"Herbert"},{"full_name":"Iglesias Ham, Mabel","first_name":"Mabel","id":"41B58C0C-F248-11E8-B48F-1D18A9856A87","last_name":"Iglesias Ham"}],"intvolume":"        68","quality_controlled":"1","ddc":["000"],"year":"2018","file":[{"relation":"main_file","file_id":"5953","date_updated":"2020-07-14T12:46:38Z","content_type":"application/pdf","creator":"dernst","date_created":"2019-02-12T06:47:52Z","file_name":"2018_Edelsbrunner.pdf","access_level":"open_access","file_size":708357,"checksum":"1c8d58cd489a66cd3e2064c1141c8c5e"}],"has_accepted_license":"1","doi":"10.1016/j.comgeo.2017.06.014","publication_status":"published","article_processing_charge":"No","oa_version":"Preprint","project":[{"grant_number":"318493","name":"Topological Complex Systems","_id":"255D761E-B435-11E9-9278-68D0E5697425","call_identifier":"FP7"}]},{"issue":"6","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","file_date_updated":"2020-07-14T12:46:38Z","scopus_import":1,"status":"public","title":"Communication-efficient randomized consensus","publication_identifier":{"issn":["01782770"]},"page":"489-501","type":"journal_article","publist_id":"7281","department":[{"_id":"DaAl"}],"day":"01","_id":"536","publisher":"Springer","citation":{"short":"D.-A. Alistarh, J. Aspnes, V. King, J. Saia, Distributed Computing 31 (2018) 489–501.","apa":"Alistarh, D.-A., Aspnes, J., King, V., &#38; Saia, J. (2018). Communication-efficient randomized consensus. <i>Distributed Computing</i>. Springer. <a href=\"https://doi.org/10.1007/s00446-017-0315-1\">https://doi.org/10.1007/s00446-017-0315-1</a>","ama":"Alistarh D-A, Aspnes J, King V, Saia J. Communication-efficient randomized consensus. <i>Distributed Computing</i>. 2018;31(6):489-501. doi:<a href=\"https://doi.org/10.1007/s00446-017-0315-1\">10.1007/s00446-017-0315-1</a>","ista":"Alistarh D-A, Aspnes J, King V, Saia J. 2018. Communication-efficient randomized consensus. Distributed Computing. 31(6), 489–501.","mla":"Alistarh, Dan-Adrian, et al. “Communication-Efficient Randomized Consensus.” <i>Distributed Computing</i>, vol. 31, no. 6, Springer, 2018, pp. 489–501, doi:<a href=\"https://doi.org/10.1007/s00446-017-0315-1\">10.1007/s00446-017-0315-1</a>.","chicago":"Alistarh, Dan-Adrian, James Aspnes, Valerie King, and Jared Saia. “Communication-Efficient Randomized Consensus.” <i>Distributed Computing</i>. Springer, 2018. <a href=\"https://doi.org/10.1007/s00446-017-0315-1\">https://doi.org/10.1007/s00446-017-0315-1</a>.","ieee":"D.-A. Alistarh, J. Aspnes, V. King, and J. Saia, “Communication-efficient randomized consensus,” <i>Distributed Computing</i>, vol. 31, no. 6. Springer, pp. 489–501, 2018."},"oa":1,"date_updated":"2023-02-23T12:23:25Z","volume":31,"abstract":[{"text":"We consider the problem of consensus in the challenging classic model. In this model, the adversary is adaptive; it can choose which processors crash at any point during the course of the algorithm. Further, communication is via asynchronous message passing: there is no known upper bound on the time to send a message from one processor to another, and all messages and coin flips are seen by the adversary. We describe a new randomized consensus protocol with expected message complexity O(n2log2n) when fewer than n / 2 processes may fail by crashing. This is an almost-linear improvement over the best previously known protocol, and within logarithmic factors of a known Ω(n2) message lower bound. The protocol further ensures that no process sends more than O(nlog3n) messages in expectation, which is again within logarithmic factors of optimal. We also present a generalization of the algorithm to an arbitrary number of failures t, which uses expected O(nt+t2log2t) total messages. Our approach is to build a message-efficient, resilient mechanism for aggregating individual processor votes, implementing the message-passing equivalent of a weak shared coin. Roughly, in our protocol, a processor first announces its votes to small groups, then propagates them to increasingly larger groups as it generates more and more votes. To bound the number of messages that an individual process might have to send or receive, the protocol progressively increases the weight of generated votes. The main technical challenge is bounding the impact of votes that are still “in flight” (generated, but not fully propagated) on the final outcome of the shared coin, especially since such votes might have different weights. We achieve this by leveraging the structure of the algorithm, and a technical argument based on martingale concentration bounds. Overall, we show that it is possible to build an efficient message-passing implementation of a shared coin, and in the process (almost-optimally) solve the classic consensus problem in the asynchronous message-passing model.","lang":"eng"}],"date_created":"2018-12-11T11:47:01Z","language":[{"iso":"eng"}],"oa_version":"Published Version","project":[{"_id":"B67AFEDC-15C9-11EA-A837-991A96BB2854","name":"IST Austria Open Access Fund"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"publication_status":"published","article_processing_charge":"Yes (via OA deal)","year":"2018","file":[{"file_size":595707,"checksum":"69b46e537acdcac745237ddb853fcbb5","file_name":"2017_DistribComp_Alistarh.pdf","date_created":"2019-01-22T07:25:51Z","creator":"dernst","access_level":"open_access","relation":"main_file","content_type":"application/pdf","file_id":"5867","date_updated":"2020-07-14T12:46:38Z"}],"has_accepted_license":"1","doi":"10.1007/s00446-017-0315-1","ddc":["000"],"quality_controlled":"1","author":[{"orcid":"0000-0003-3650-940X","first_name":"Dan-Adrian","full_name":"Alistarh, Dan-Adrian","id":"4A899BFC-F248-11E8-B48F-1D18A9856A87","last_name":"Alistarh"},{"full_name":"Aspnes, James","first_name":"James","last_name":"Aspnes"},{"last_name":"King","first_name":"Valerie","full_name":"King, Valerie"},{"full_name":"Saia, Jared","first_name":"Jared","last_name":"Saia"}],"month":"11","intvolume":"        31","date_published":"2018-11-01T00:00:00Z","publication":"Distributed Computing"},{"doi":"10.1038/s41467-018-06899-3","has_accepted_license":"1","file":[{"checksum":"9fe2a63bd95a5067d896c087d07998f3","file_size":4651930,"file_id":"5715","date_updated":"2020-07-14T12:45:28Z","content_type":"application/pdf","relation":"main_file","access_level":"open_access","date_created":"2018-12-17T15:41:57Z","file_name":"2018_NatureComm_Espinoza.pdf","creator":"dernst"}],"year":"2018","related_material":{"link":[{"relation":"press_release","url":"https://ist.ac.at/en/news/lateral-inhibition-keeps-similar-memories-apart/","description":"News on IST Homepage"}],"record":[{"id":"6363","relation":"dissertation_contains","status":"public"}]},"ddc":["570"],"project":[{"_id":"25B7EB9E-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"692692","name":"Biophysics and circuit function of a giant cortical glumatergic synapse"},{"call_identifier":"FWF","_id":"25C5A090-B435-11E9-9278-68D0E5697425","name":"The Wittgenstein Prize","grant_number":"Z00312"}],"oa_version":"Published Version","article_processing_charge":"No","publication_status":"published","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"publication":"Nature Communications","external_id":{"isi":["000449069700009"]},"date_published":"2018-11-02T00:00:00Z","acknowledgement":"This project received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 692692) and the Fond zur Förderung der Wissenschaftlichen Forschung (Z 312-B27, Wittgenstein award), both to P.J..","quality_controlled":"1","article_number":"4605","intvolume":"         9","month":"11","author":[{"last_name":"Espinoza Martinez","id":"31FFEE2E-F248-11E8-B48F-1D18A9856A87","first_name":"Claudia ","orcid":"0000-0003-4710-2082","full_name":"Espinoza Martinez, Claudia "},{"full_name":"Guzmán, José","first_name":"José","orcid":"0000-0003-2209-5242","id":"30CC5506-F248-11E8-B48F-1D18A9856A87","last_name":"Guzmán"},{"last_name":"Zhang","id":"423EC9C2-F248-11E8-B48F-1D18A9856A87","first_name":"Xiaomin","full_name":"Zhang, Xiaomin"},{"last_name":"Jonas","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","full_name":"Jonas, Peter M","orcid":"0000-0001-5001-4804","first_name":"Peter M"}],"publist_id":"8034","type":"journal_article","title":"Parvalbumin+ interneurons obey unique connectivity rules and establish a powerful lateral-inhibition microcircuit in dentate gyrus","status":"public","scopus_import":"1","issue":"1","ec_funded":1,"file_date_updated":"2020-07-14T12:45:28Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","article_type":"original","date_updated":"2024-03-25T23:30:16Z","oa":1,"isi":1,"language":[{"iso":"eng"}],"date_created":"2018-12-11T11:44:12Z","volume":9,"abstract":[{"text":"Parvalbumin-positive (PV+) GABAergic interneurons in hippocampal microcircuits are thought to play a key role in several higher network functions, such as feedforward and feedback inhibition, network oscillations, and pattern separation. Fast lateral inhibition mediated by GABAergic interneurons may implement a winner-takes-all mechanism in the hippocampal input layer. However, it is not clear whether the functional connectivity rules of granule cells (GCs) and interneurons in the dentate gyrus are consistent with such a mechanism. Using simultaneous patch-clamp recordings from up to seven GCs and up to four PV+ interneurons in the dentate gyrus, we find that connectivity is structured in space, synapse-specific, and enriched in specific disynaptic motifs. In contrast to the neocortex, lateral inhibition in the dentate gyrus (in which a GC inhibits neighboring GCs via a PV+ interneuron) is ~ 10-times more abundant than recurrent inhibition (in which a GC inhibits itself). Thus, unique connectivity rules may enable the dentate gyrus to perform specific higher-order computations","lang":"eng"}],"department":[{"_id":"PeJo"}],"citation":{"ieee":"C. Espinoza Martinez, J. Guzmán, X. Zhang, and P. M. Jonas, “Parvalbumin+ interneurons obey unique connectivity rules and establish a powerful lateral-inhibition microcircuit in dentate gyrus,” <i>Nature Communications</i>, vol. 9, no. 1. Nature Publishing Group, 2018.","chicago":"Espinoza Martinez, Claudia , José Guzmán, Xiaomin Zhang, and Peter M Jonas. “Parvalbumin+ Interneurons Obey Unique Connectivity Rules and Establish a Powerful Lateral-Inhibition Microcircuit in Dentate Gyrus.” <i>Nature Communications</i>. Nature Publishing Group, 2018. <a href=\"https://doi.org/10.1038/s41467-018-06899-3\">https://doi.org/10.1038/s41467-018-06899-3</a>.","mla":"Espinoza Martinez, Claudia, et al. “Parvalbumin+ Interneurons Obey Unique Connectivity Rules and Establish a Powerful Lateral-Inhibition Microcircuit in Dentate Gyrus.” <i>Nature Communications</i>, vol. 9, no. 1, 4605, Nature Publishing Group, 2018, doi:<a href=\"https://doi.org/10.1038/s41467-018-06899-3\">10.1038/s41467-018-06899-3</a>.","ista":"Espinoza Martinez C, Guzmán J, Zhang X, Jonas PM. 2018. Parvalbumin+ interneurons obey unique connectivity rules and establish a powerful lateral-inhibition microcircuit in dentate gyrus. Nature Communications. 9(1), 4605.","ama":"Espinoza Martinez C, Guzmán J, Zhang X, Jonas PM. Parvalbumin+ interneurons obey unique connectivity rules and establish a powerful lateral-inhibition microcircuit in dentate gyrus. <i>Nature Communications</i>. 2018;9(1). doi:<a href=\"https://doi.org/10.1038/s41467-018-06899-3\">10.1038/s41467-018-06899-3</a>","apa":"Espinoza Martinez, C., Guzmán, J., Zhang, X., &#38; Jonas, P. M. (2018). Parvalbumin+ interneurons obey unique connectivity rules and establish a powerful lateral-inhibition microcircuit in dentate gyrus. <i>Nature Communications</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/s41467-018-06899-3\">https://doi.org/10.1038/s41467-018-06899-3</a>","short":"C. Espinoza Martinez, J. Guzmán, X. Zhang, P.M. Jonas, Nature Communications 9 (2018)."},"_id":"21","publisher":"Nature Publishing Group","day":"02"},{"language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"Conventional ultra-high sensitivity detectors in the millimeter-wave range are usually cooled as their own thermal noise at room temperature would mask the weak received radiation. The need for cryogenic systems increases the cost and complexity of the instruments, hindering the development of, among others, airborne and space applications. In this work, the nonlinear parametric upconversion of millimeter-wave radiation to the optical domain inside high-quality (Q) lithium niobate whispering-gallery mode (WGM) resonators is proposed for ultra-low noise detection. We experimentally demonstrate coherent upconversion of millimeter-wave signals to a 1550 nm telecom carrier, with a photon conversion efficiency surpassing the state-of-the-art by 2 orders of magnitude. Moreover, a theoretical model shows that the thermal equilibrium of counterpropagating WGMs is broken by overcoupling the millimeter-wave WGM, effectively cooling the upconverted mode and allowing ultra-low noise detection. By theoretically estimating the sensitivity of a correlation radiometer based on the presented scheme, it is found that room-temperature radiometers with better sensitivity than state-of-the-art high-electron-mobility transistor (HEMT)-based radiometers can be designed. This detection paradigm can be used to develop room-temperature instrumentation for radio astronomy, earth observation, planetary missions, and imaging systems."}],"date_created":"2018-12-11T11:44:12Z","volume":5,"main_file_link":[{"url":"www.doi.org/10.1364/OPTICA.5.001210 ","open_access":"1"}],"article_type":"original","date_updated":"2023-10-17T12:12:40Z","isi":1,"oa":1,"citation":{"ama":"Botello G, Sedlmeir F, Rueda Sanchez AR, et al. Sensitivity limits of millimeter-wave photonic radiometers based on efficient electro-optic upconverters. <i>Optica</i>. 2018;5(10):1210-1219. doi:<a href=\"https://doi.org/10.1364/OPTICA.5.001210\">10.1364/OPTICA.5.001210</a>","apa":"Botello, G., Sedlmeir, F., Rueda Sanchez, A. R., Abdalmalak, K., Brown, E., Leuchs, G., … Schwefel, H. (2018). Sensitivity limits of millimeter-wave photonic radiometers based on efficient electro-optic upconverters. <i>Optica</i>. <a href=\"https://doi.org/10.1364/OPTICA.5.001210\">https://doi.org/10.1364/OPTICA.5.001210</a>","short":"G. Botello, F. Sedlmeir, A.R. Rueda Sanchez, K. Abdalmalak, E. Brown, G. Leuchs, S. Preu, D. Segovia Vargas, D. Strekalov, L. Munoz, H. Schwefel, Optica 5 (2018) 1210–1219.","ieee":"G. Botello <i>et al.</i>, “Sensitivity limits of millimeter-wave photonic radiometers based on efficient electro-optic upconverters,” <i>Optica</i>, vol. 5, no. 10. pp. 1210–1219, 2018.","ista":"Botello G, Sedlmeir F, Rueda Sanchez AR, Abdalmalak K, Brown E, Leuchs G, Preu S, Segovia Vargas D, Strekalov D, Munoz L, Schwefel H. 2018. Sensitivity limits of millimeter-wave photonic radiometers based on efficient electro-optic upconverters. Optica. 5(10), 1210–1219.","mla":"Botello, Gabriel, et al. “Sensitivity Limits of Millimeter-Wave Photonic Radiometers Based on Efficient Electro-Optic Upconverters.” <i>Optica</i>, vol. 5, no. 10, 2018, pp. 1210–19, doi:<a href=\"https://doi.org/10.1364/OPTICA.5.001210\">10.1364/OPTICA.5.001210</a>.","chicago":"Botello, Gabriel, Florian Sedlmeir, Alfredo R Rueda Sanchez, Kerlos Abdalmalak, Elliott Brown, Gerd Leuchs, Sascha Preu, et al. “Sensitivity Limits of Millimeter-Wave Photonic Radiometers Based on Efficient Electro-Optic Upconverters.” <i>Optica</i>, 2018. <a href=\"https://doi.org/10.1364/OPTICA.5.001210\">https://doi.org/10.1364/OPTICA.5.001210</a>."},"day":"20","_id":"22","department":[{"_id":"JoFi"}],"type":"journal_article","publist_id":"8033","publication_identifier":{"issn":["23342536"]},"scopus_import":"1","status":"public","title":"Sensitivity limits of millimeter-wave photonic radiometers based on efficient electro-optic upconverters","page":"1210 - 1219","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","issue":"10","publication":"Optica","external_id":{"isi":["000447853100007"]},"date_published":"2018-10-20T00:00:00Z","intvolume":"         5","author":[{"full_name":"Botello, Gabriel","first_name":"Gabriel","last_name":"Botello"},{"full_name":"Sedlmeir, Florian","first_name":"Florian","last_name":"Sedlmeir"},{"last_name":"Rueda Sanchez","id":"3B82B0F8-F248-11E8-B48F-1D18A9856A87","full_name":"Rueda Sanchez, Alfredo R","orcid":"0000-0001-6249-5860","first_name":"Alfredo R"},{"full_name":"Abdalmalak, Kerlos","first_name":"Kerlos","last_name":"Abdalmalak"},{"last_name":"Brown","full_name":"Brown, Elliott","first_name":"Elliott"},{"last_name":"Leuchs","first_name":"Gerd","full_name":"Leuchs, Gerd"},{"full_name":"Preu, Sascha","first_name":"Sascha","last_name":"Preu"},{"first_name":"Daniel","full_name":"Segovia Vargas, Daniel","last_name":"Segovia Vargas"},{"last_name":"Strekalov","full_name":"Strekalov, Dmitry","first_name":"Dmitry"},{"last_name":"Munoz","first_name":"Luis","full_name":"Munoz, Luis"},{"first_name":"Harald","full_name":"Schwefel, Harald","last_name":"Schwefel"}],"month":"10","quality_controlled":"1","doi":"10.1364/OPTICA.5.001210","year":"2018","article_processing_charge":"No","publication_status":"published","oa_version":"Published Version"},{"quality_controlled":"1","author":[{"first_name":"Lada","full_name":"Vukušić, Lada","orcid":"0000-0003-2424-8636","last_name":"Vukušić","id":"31E9F056-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Josip","full_name":"Kukucka, Josip","last_name":"Kukucka","id":"3F5D8856-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Hannes","full_name":"Watzinger, Hannes","last_name":"Watzinger","id":"35DF8E50-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Milem","id":"4CDE0A96-F248-11E8-B48F-1D18A9856A87","full_name":"Milem, Joshua M","first_name":"Joshua M"},{"last_name":"Schäffler","first_name":"Friedrich","full_name":"Schäffler, Friedrich"},{"full_name":"Katsaros, Georgios","orcid":"0000-0001-8342-202X","first_name":"Georgios","id":"38DB5788-F248-11E8-B48F-1D18A9856A87","last_name":"Katsaros"}],"month":"10","intvolume":"        18","publication":"Nano Letters","external_id":{"pmid":["30359041"],"isi":["000451102100064"]},"date_published":"2018-10-25T00:00:00Z","pmid":1,"project":[{"name":"Towards Spin qubits and Majorana fermions in Germanium selfassembled hut-wires","grant_number":"335497","call_identifier":"FP7","_id":"25517E86-B435-11E9-9278-68D0E5697425"}],"oa_version":"Published Version","article_processing_charge":"No","publication_status":"published","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"doi":"10.1021/acs.nanolett.8b03217","file":[{"file_size":1361441,"checksum":"3e6034a94c6b5335e939145d88bdb371","access_level":"open_access","creator":"system","date_created":"2018-12-12T10:16:08Z","file_name":"IST-2018-1065-v1+1_ACS_nanoletters_8b03217.pdf","content_type":"application/pdf","file_id":"5194","date_updated":"2020-07-14T12:45:37Z","relation":"main_file"}],"has_accepted_license":"1","year":"2018","related_material":{"record":[{"id":"7977","relation":"popular_science"},{"id":"69","status":"public","relation":"dissertation_contains"},{"status":"public","relation":"dissertation_contains","id":"7996"}]},"ddc":["530"],"department":[{"_id":"GeKa"}],"citation":{"ieee":"L. Vukušić, J. Kukucka, H. Watzinger, J. M. Milem, F. Schäffler, and G. Katsaros, “Single-shot readout of hole spins in Ge,” <i>Nano Letters</i>, vol. 18, no. 11. American Chemical Society, pp. 7141–7145, 2018.","mla":"Vukušić, Lada, et al. “Single-Shot Readout of Hole Spins in Ge.” <i>Nano Letters</i>, vol. 18, no. 11, American Chemical Society, 2018, pp. 7141–45, doi:<a href=\"https://doi.org/10.1021/acs.nanolett.8b03217\">10.1021/acs.nanolett.8b03217</a>.","ista":"Vukušić L, Kukucka J, Watzinger H, Milem JM, Schäffler F, Katsaros G. 2018. Single-shot readout of hole spins in Ge. Nano Letters. 18(11), 7141–7145.","chicago":"Vukušić, Lada, Josip Kukucka, Hannes Watzinger, Joshua M Milem, Friedrich Schäffler, and Georgios Katsaros. “Single-Shot Readout of Hole Spins in Ge.” <i>Nano Letters</i>. American Chemical Society, 2018. <a href=\"https://doi.org/10.1021/acs.nanolett.8b03217\">https://doi.org/10.1021/acs.nanolett.8b03217</a>.","ama":"Vukušić L, Kukucka J, Watzinger H, Milem JM, Schäffler F, Katsaros G. Single-shot readout of hole spins in Ge. <i>Nano Letters</i>. 2018;18(11):7141-7145. doi:<a href=\"https://doi.org/10.1021/acs.nanolett.8b03217\">10.1021/acs.nanolett.8b03217</a>","apa":"Vukušić, L., Kukucka, J., Watzinger, H., Milem, J. M., Schäffler, F., &#38; Katsaros, G. (2018). Single-shot readout of hole spins in Ge. <i>Nano Letters</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acs.nanolett.8b03217\">https://doi.org/10.1021/acs.nanolett.8b03217</a>","short":"L. Vukušić, J. Kukucka, H. Watzinger, J.M. Milem, F. Schäffler, G. Katsaros, Nano Letters 18 (2018) 7141–7145."},"_id":"23","pubrep_id":"1065","publisher":"American Chemical Society","day":"25","date_updated":"2023-09-18T09:30:37Z","oa":1,"isi":1,"language":[{"iso":"eng"}],"volume":18,"date_created":"2018-12-11T11:44:13Z","abstract":[{"text":"The strong atomistic spin–orbit coupling of holes makes single-shot spin readout measurements difficult because it reduces the spin lifetimes. By integrating the charge sensor into a high bandwidth radio frequency reflectometry setup, we were able to demonstrate single-shot readout of a germanium quantum dot hole spin and measure the spin lifetime. Hole spin relaxation times of about 90 μs at 500 mT are reported, with a total readout visibility of about 70%. By analyzing separately the spin-to-charge conversion and charge readout fidelities, we have obtained insight into the processes limiting the visibilities of hole spins. The analyses suggest that high hole visibilities are feasible at realistic experimental conditions, underlying the potential of hole spins for the realization of viable qubit devices.","lang":"eng"}],"issue":"11","file_date_updated":"2020-07-14T12:45:37Z","ec_funded":1,"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","acknowledged_ssus":[{"_id":"M-Shop"},{"_id":"NanoFab"}],"type":"journal_article","publist_id":"8032","page":"7141 - 7145","status":"public","scopus_import":"1","publication_identifier":{"issn":["15306984"]},"title":"Single-shot readout of hole spins in Ge"},{"quality_controlled":"1","month":"07","intvolume":"      2018","author":[{"id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","last_name":"Chatterjee","first_name":"Krishnendu","orcid":"0000-0002-4561-241X","full_name":"Chatterjee, Krishnendu"},{"id":"4A2E9DBA-F248-11E8-B48F-1D18A9856A87","last_name":"Elgyütt","full_name":"Elgyütt, Adrian","first_name":"Adrian"},{"full_name":"Novotny, Petr","first_name":"Petr","id":"3CC3B868-F248-11E8-B48F-1D18A9856A87","last_name":"Novotny"},{"last_name":"Rouillé","first_name":"Owen","full_name":"Rouillé, Owen"}],"date_published":"2018-07-01T00:00:00Z","conference":{"start_date":"2018-07-13","end_date":"2018-07-19","name":"IJCAI: International Joint Conference on Artificial Intelligence","location":"Stockholm, Sweden"},"external_id":{"isi":["000764175404117"],"arxiv":["1804.10601"]},"acknowledgement":"This research was supported by the Vienna Science and Technology Fund (WWTF) grant ICT15-003; Austrian Science Fund (FWF): S11407-N23(RiSE/SHiNE);and an ERC Start Grant (279307:Graph Games).\r\n","arxiv":1,"oa_version":"Preprint","project":[{"_id":"25892FC0-B435-11E9-9278-68D0E5697425","grant_number":"ICT15-003","name":"Efficient Algorithms for Computer Aided Verification"},{"call_identifier":"FWF","_id":"25832EC2-B435-11E9-9278-68D0E5697425","name":"Rigorous Systems Engineering","grant_number":"S 11407_N23"},{"_id":"2581B60A-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","grant_number":"279307","name":"Quantitative Graph Games: Theory and Applications"}],"publication_status":"published","article_processing_charge":"No","year":"2018","doi":"10.24963/ijcai.2018/652","department":[{"_id":"KrCh"},{"_id":"ToHe"}],"_id":"24","publisher":"IJCAI","day":"01","citation":{"apa":"Chatterjee, K., Elgyütt, A., Novotný, P., &#38; Rouillé, O. (2018). Expectation optimization with probabilistic guarantees in POMDPs with discounted-sum objectives (Vol. 2018, pp. 4692–4699). Presented at the IJCAI: International Joint Conference on Artificial Intelligence, Stockholm, Sweden: IJCAI. <a href=\"https://doi.org/10.24963/ijcai.2018/652\">https://doi.org/10.24963/ijcai.2018/652</a>","ama":"Chatterjee K, Elgyütt A, Novotný P, Rouillé O. Expectation optimization with probabilistic guarantees in POMDPs with discounted-sum objectives. In: Vol 2018. IJCAI; 2018:4692-4699. doi:<a href=\"https://doi.org/10.24963/ijcai.2018/652\">10.24963/ijcai.2018/652</a>","short":"K. Chatterjee, A. Elgyütt, P. Novotný, O. Rouillé, in:, IJCAI, 2018, pp. 4692–4699.","ista":"Chatterjee K, Elgyütt A, Novotný P, Rouillé O. 2018. Expectation optimization with probabilistic guarantees in POMDPs with discounted-sum objectives. IJCAI: International Joint Conference on Artificial Intelligence vol. 2018, 4692–4699.","chicago":"Chatterjee, Krishnendu, Adrian Elgyütt, Petr Novotný, and Owen Rouillé. “Expectation Optimization with Probabilistic Guarantees in POMDPs with Discounted-Sum Objectives,” 2018:4692–99. IJCAI, 2018. <a href=\"https://doi.org/10.24963/ijcai.2018/652\">https://doi.org/10.24963/ijcai.2018/652</a>.","mla":"Chatterjee, Krishnendu, et al. <i>Expectation Optimization with Probabilistic Guarantees in POMDPs with Discounted-Sum Objectives</i>. Vol. 2018, IJCAI, 2018, pp. 4692–99, doi:<a href=\"https://doi.org/10.24963/ijcai.2018/652\">10.24963/ijcai.2018/652</a>.","ieee":"K. Chatterjee, A. Elgyütt, P. Novotný, and O. Rouillé, “Expectation optimization with probabilistic guarantees in POMDPs with discounted-sum objectives,” presented at the IJCAI: International Joint Conference on Artificial Intelligence, Stockholm, Sweden, 2018, vol. 2018, pp. 4692–4699."},"oa":1,"isi":1,"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1804.10601"}],"date_updated":"2025-06-02T08:53:48Z","abstract":[{"text":"Partially-observable Markov decision processes (POMDPs) with discounted-sum payoff are a standard framework to model a wide range of problems related to decision making under uncertainty. Traditionally, the goal has been to obtain policies that optimize the expectation of the discounted-sum payoff. A key drawback of the expectation measure is that even low probability events with extreme payoff can significantly affect the expectation, and thus the obtained policies are not necessarily risk-averse. An alternate approach is to optimize the probability that the payoff is above a certain threshold, which allows obtaining risk-averse policies, but ignores optimization of the expectation. We consider the expectation optimization with probabilistic guarantee (EOPG) problem, where the goal is to optimize the expectation ensuring that the payoff is above a given threshold with at least a specified probability. We present several results on the EOPG problem, including the first algorithm to solve it.","lang":"eng"}],"volume":2018,"date_created":"2018-12-11T11:44:13Z","language":[{"iso":"eng"}],"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","ec_funded":1,"page":"4692 - 4699","title":"Expectation optimization with probabilistic guarantees in POMDPs with discounted-sum objectives","scopus_import":"1","status":"public","type":"conference","publist_id":"8031"},{"quality_controlled":"1","author":[{"first_name":"Karel","full_name":"Horák, Karel","last_name":"Horák"},{"first_name":"Branislav","full_name":"Bošanský, Branislav","last_name":"Bošanský"},{"id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","last_name":"Chatterjee","full_name":"Chatterjee, Krishnendu","orcid":"0000-0002-4561-241X","first_name":"Krishnendu"}],"month":"07","external_id":{"isi":["000764175404127"]},"publication":"Proceedings of the Twenty-Seventh International Joint Conference on Artificial Intelligence","conference":{"name":"IJCAI: International Joint Conference on Artificial Intelligence","location":"Stockholm, Sweden","start_date":"2018-07-13","end_date":"2018-07-19"},"date_published":"2018-07-01T00:00:00Z","acknowledgement":"∗This work has been supported by Vienna Science and Technology Fund (WWTF) Project ICT15-003, Austrian Science Fund (FWF) NFN Grant No S11407-N23 (RiSE/SHiNE), and ERC Starting grant (279307: Graph Games). This research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-13-2-0045 (ARL Cyber Security CRA). ","oa_version":"Published Version","project":[{"name":"Efficient Algorithms for Computer Aided Verification","grant_number":"ICT15-003","_id":"25892FC0-B435-11E9-9278-68D0E5697425"},{"_id":"25832EC2-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","grant_number":"S 11407_N23","name":"Rigorous Systems Engineering"},{"name":"Quantitative Graph Games: Theory and Applications","grant_number":"279307","call_identifier":"FP7","_id":"2581B60A-B435-11E9-9278-68D0E5697425"}],"article_processing_charge":"No","publication_status":"published","doi":"10.24963/ijcai.2018/662","year":"2018","department":[{"_id":"KrCh"}],"citation":{"short":"K. Horák, B. Bošanský, K. Chatterjee, in:, Proceedings of the Twenty-Seventh International Joint Conference on Artificial Intelligence, IJCAI, 2018, pp. 4764–4770.","apa":"Horák, K., Bošanský, B., &#38; Chatterjee, K. (2018). Goal-HSVI: Heuristic search value iteration for goal-POMDPs. In <i>Proceedings of the Twenty-Seventh International Joint Conference on Artificial Intelligence</i> (Vol. 2018–July, pp. 4764–4770). Stockholm, Sweden: IJCAI. <a href=\"https://doi.org/10.24963/ijcai.2018/662\">https://doi.org/10.24963/ijcai.2018/662</a>","ama":"Horák K, Bošanský B, Chatterjee K. Goal-HSVI: Heuristic search value iteration for goal-POMDPs. In: <i>Proceedings of the Twenty-Seventh International Joint Conference on Artificial Intelligence</i>. Vol 2018-July. IJCAI; 2018:4764-4770. doi:<a href=\"https://doi.org/10.24963/ijcai.2018/662\">10.24963/ijcai.2018/662</a>","chicago":"Horák, Karel, Branislav Bošanský, and Krishnendu Chatterjee. “Goal-HSVI: Heuristic Search Value Iteration for Goal-POMDPs.” In <i>Proceedings of the Twenty-Seventh International Joint Conference on Artificial Intelligence</i>, 2018–July:4764–70. IJCAI, 2018. <a href=\"https://doi.org/10.24963/ijcai.2018/662\">https://doi.org/10.24963/ijcai.2018/662</a>.","mla":"Horák, Karel, et al. “Goal-HSVI: Heuristic Search Value Iteration for Goal-POMDPs.” <i>Proceedings of the Twenty-Seventh International Joint Conference on Artificial Intelligence</i>, vol. 2018–July, IJCAI, 2018, pp. 4764–70, doi:<a href=\"https://doi.org/10.24963/ijcai.2018/662\">10.24963/ijcai.2018/662</a>.","ista":"Horák K, Bošanský B, Chatterjee K. 2018. Goal-HSVI: Heuristic search value iteration for goal-POMDPs. Proceedings of the Twenty-Seventh International Joint Conference on Artificial Intelligence. IJCAI: International Joint Conference on Artificial Intelligence vol. 2018–July, 4764–4770.","ieee":"K. Horák, B. Bošanský, and K. Chatterjee, “Goal-HSVI: Heuristic search value iteration for goal-POMDPs,” in <i>Proceedings of the Twenty-Seventh International Joint Conference on Artificial Intelligence</i>, Stockholm, Sweden, 2018, vol. 2018–July, pp. 4764–4770."},"day":"01","_id":"25","publisher":"IJCAI","date_updated":"2025-06-02T08:53:40Z","main_file_link":[{"url":"https://doi.org/10.24963/ijcai.2018/662","open_access":"1"}],"isi":1,"oa":1,"language":[{"iso":"eng"}],"date_created":"2018-12-11T11:44:13Z","abstract":[{"lang":"eng","text":"Partially observable Markov decision processes (POMDPs) are the standard models for planning under uncertainty with both finite and infinite horizon. Besides the well-known discounted-sum objective, indefinite-horizon objective (aka Goal-POMDPs) is another classical objective for POMDPs. In this case, given a set of target states and a positive cost for each transition, the optimization objective is to minimize the expected total cost until a target state is reached. In the literature, RTDP-Bel or heuristic search value iteration (HSVI) have been used for solving Goal-POMDPs. Neither of these algorithms has theoretical convergence guarantees, and HSVI may even fail to terminate its trials. We give the following contributions: (1) We discuss the challenges introduced in Goal-POMDPs and illustrate how they prevent the original HSVI from converging. (2) We present a novel algorithm inspired by HSVI, termed Goal-HSVI, and show that our algorithm has convergence guarantees. (3) We show that Goal-HSVI outperforms RTDP-Bel on a set of well-known examples."}],"volume":"2018-July","ec_funded":1,"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","type":"conference","publist_id":"8030","status":"public","title":"Goal-HSVI: Heuristic search value iteration for goal-POMDPs","scopus_import":"1","page":"4764 - 4770"},{"doi":"10.15479/AT:ISTA:th1059","has_accepted_license":"1","file":[{"access_level":"closed","file_name":"Thesis_Steinrueck_final.docx","date_created":"2019-02-08T10:51:22Z","creator":"dernst","date_updated":"2020-07-14T12:45:43Z","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","file_id":"5941","relation":"source_file","file_size":9190845,"checksum":"413cbce1cd1debeae3abe2a25dbc70d1","embargo_to":"open_access"},{"file_size":7521973,"checksum":"3def8b7854c8b42d643597ce0215efac","relation":"main_file","date_updated":"2021-02-11T11:17:14Z","file_id":"5942","content_type":"application/pdf","embargo":"2019-11-02","creator":"dernst","file_name":"Thesis_Steinrueck_final.pdf","date_created":"2019-02-08T10:51:22Z","access_level":"open_access"}],"supervisor":[{"full_name":"Guet, Calin C","first_name":"Calin C","orcid":"0000-0001-6220-2052","last_name":"Guet","id":"47F8433E-F248-11E8-B48F-1D18A9856A87"}],"year":"2018","related_material":{"record":[{"id":"704","relation":"part_of_dissertation","status":"public"}]},"ddc":["576","579"],"oa_version":"Published Version","article_processing_charge":"No","publication_status":"published","date_published":"2018-10-30T00:00:00Z","degree_awarded":"PhD","author":[{"orcid":"0000-0003-1229-9719","first_name":"Magdalena","full_name":"Steinrück, Magdalena","id":"2C023F40-F248-11E8-B48F-1D18A9856A87","last_name":"Steinrück"}],"month":"10","type":"dissertation","publist_id":"8029","page":"109","title":"The influence of sequence context on the evolution of bacterial gene expression","status":"public","publication_identifier":{"issn":["2663-337X"]},"file_date_updated":"2021-02-11T11:17:14Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","date_updated":"2023-09-07T12:48:43Z","oa":1,"language":[{"iso":"eng"}],"date_created":"2018-12-11T11:44:14Z","abstract":[{"lang":"eng","text":"Expression of genes is a fundamental molecular phenotype that is subject to evolution by different types of mutations. Both the rate and the effect of mutations may depend on the DNA sequence context of a particular gene or a particular promoter sequence. In this thesis I investigate the nature of this dependence using simple genetic systems in Escherichia coli. With these systems I explore the evolution of constitutive gene expression from random starting sequences at different loci on the chromosome and at different locations in sequence space. First, I dissect chromosomal neighborhood effects that underlie locus-dependent differences in the potential of a gene under selection to become more highly expressed. Next, I find that the effects of point mutations in promoter sequences are dependent on sequence context, and that an existing energy matrix model performs poorly in predicting relative expression of unrelated sequences. Finally, I show that a substantial fraction of random sequences contain functional promoters and I present an extended thermodynamic model that predicts promoter strength in full sequence space. Taken together, these results provide new insights and guides on how to integrate information on sequence context to improve our qualitative and quantitative understanding of bacterial gene expression, with implications for rapid evolution of drug resistance, de novo evolution of genes, and horizontal gene transfer."}],"alternative_title":["ISTA Thesis"],"department":[{"_id":"CaGu"}],"citation":{"short":"M. Steinrück, The Influence of Sequence Context on the Evolution of Bacterial Gene Expression, Institute of Science and Technology Austria, 2018.","apa":"Steinrück, M. (2018). <i>The influence of sequence context on the evolution of bacterial gene expression</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:th1059\">https://doi.org/10.15479/AT:ISTA:th1059</a>","ama":"Steinrück M. The influence of sequence context on the evolution of bacterial gene expression. 2018. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th1059\">10.15479/AT:ISTA:th1059</a>","mla":"Steinrück, Magdalena. <i>The Influence of Sequence Context on the Evolution of Bacterial Gene Expression</i>. Institute of Science and Technology Austria, 2018, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th1059\">10.15479/AT:ISTA:th1059</a>.","ista":"Steinrück M. 2018. The influence of sequence context on the evolution of bacterial gene expression. Institute of Science and Technology Austria.","chicago":"Steinrück, Magdalena. “The Influence of Sequence Context on the Evolution of Bacterial Gene Expression.” Institute of Science and Technology Austria, 2018. <a href=\"https://doi.org/10.15479/AT:ISTA:th1059\">https://doi.org/10.15479/AT:ISTA:th1059</a>.","ieee":"M. Steinrück, “The influence of sequence context on the evolution of bacterial gene expression,” Institute of Science and Technology Austria, 2018."},"pubrep_id":"1059","_id":"26","publisher":"Institute of Science and Technology Austria","day":"30"},{"_id":"273","publisher":"IEEE","day":"28","citation":{"apa":"Mohapatra, P., Rolinek, M., Jawahar, C. V., Kolmogorov, V., &#38; Kumar, M. P. (2018). Efficient optimization for rank-based loss functions. In <i>2018 IEEE/CVF Conference on Computer Vision and Pattern Recognition</i> (pp. 3693–3701). Salt Lake City, UT, USA: IEEE. <a href=\"https://doi.org/10.1109/cvpr.2018.00389\">https://doi.org/10.1109/cvpr.2018.00389</a>","ama":"Mohapatra P, Rolinek M, Jawahar CV, Kolmogorov V, Kumar MP. Efficient optimization for rank-based loss functions. In: <i>2018 IEEE/CVF Conference on Computer Vision and Pattern Recognition</i>. IEEE; 2018:3693-3701. doi:<a href=\"https://doi.org/10.1109/cvpr.2018.00389\">10.1109/cvpr.2018.00389</a>","short":"P. Mohapatra, M. Rolinek, C.V. Jawahar, V. Kolmogorov, M.P. Kumar, in:, 2018 IEEE/CVF Conference on Computer Vision and Pattern Recognition, IEEE, 2018, pp. 3693–3701.","mla":"Mohapatra, Pritish, et al. “Efficient Optimization for Rank-Based Loss Functions.” <i>2018 IEEE/CVF Conference on Computer Vision and Pattern Recognition</i>, IEEE, 2018, pp. 3693–701, doi:<a href=\"https://doi.org/10.1109/cvpr.2018.00389\">10.1109/cvpr.2018.00389</a>.","chicago":"Mohapatra, Pritish, Michal Rolinek, C V Jawahar, Vladimir Kolmogorov, and M Pawan Kumar. “Efficient Optimization for Rank-Based Loss Functions.” In <i>2018 IEEE/CVF Conference on Computer Vision and Pattern Recognition</i>, 3693–3701. IEEE, 2018. <a href=\"https://doi.org/10.1109/cvpr.2018.00389\">https://doi.org/10.1109/cvpr.2018.00389</a>.","ista":"Mohapatra P, Rolinek M, Jawahar CV, Kolmogorov V, Kumar MP. 2018. Efficient optimization for rank-based loss functions. 2018 IEEE/CVF Conference on Computer Vision and Pattern Recognition. CVPR: Conference on Computer Vision and Pattern Recognition, 3693–3701.","ieee":"P. Mohapatra, M. Rolinek, C. V. Jawahar, V. Kolmogorov, and M. P. Kumar, “Efficient optimization for rank-based loss functions,” in <i>2018 IEEE/CVF Conference on Computer Vision and Pattern Recognition</i>, Salt Lake City, UT, USA, 2018, pp. 3693–3701."},"department":[{"_id":"VlKo"}],"abstract":[{"lang":"eng","text":"The accuracy of information retrieval systems is often measured using complex loss functions such as the average precision (AP) or the normalized discounted cumulative gain (NDCG). Given a set of positive and negative samples, the parameters of a retrieval system can be estimated by minimizing these loss functions. However, the non-differentiability and non-decomposability of these loss functions does not allow for simple gradient based optimization algorithms. This issue is generally circumvented by either optimizing a structured hinge-loss upper bound to the loss function or by using asymptotic methods like the direct-loss minimization framework. Yet, the high computational complexity of loss-augmented inference, which is necessary for both the frameworks, prohibits its use in large training data sets. To alleviate this deficiency, we present a novel quicksort flavored algorithm for a large class of non-decomposable loss functions. We provide a complete characterization of the loss functions that are amenable to our algorithm, and show that it includes both AP and NDCG based loss functions. Furthermore, we prove that no comparison based algorithm can improve upon the computational complexity of our approach asymptotically. We demonstrate the effectiveness of our approach in the context of optimizing the structured hinge loss upper bound of AP and NDCG loss for learning models for a variety of vision tasks. We show that our approach provides significantly better results than simpler decomposable loss functions, while requiring a comparable training time."}],"date_created":"2018-12-11T11:45:33Z","language":[{"iso":"eng"}],"oa":1,"isi":1,"date_updated":"2023-09-11T13:24:43Z","main_file_link":[{"url":"https://arxiv.org/abs/1604.08269","open_access":"1"}],"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","ec_funded":1,"page":"3693-3701","title":"Efficient optimization for rank-based loss functions","status":"public","scopus_import":"1","publication_identifier":{"isbn":["9781538664209"]},"type":"conference","author":[{"last_name":"Mohapatra","first_name":"Pritish","full_name":"Mohapatra, Pritish"},{"id":"3CB3BC06-F248-11E8-B48F-1D18A9856A87","last_name":"Rolinek","full_name":"Rolinek, Michal","first_name":"Michal"},{"last_name":"Jawahar","full_name":"Jawahar, C V","first_name":"C V"},{"last_name":"Kolmogorov","id":"3D50B0BA-F248-11E8-B48F-1D18A9856A87","first_name":"Vladimir","full_name":"Kolmogorov, Vladimir"},{"last_name":"Kumar","full_name":"Kumar, M Pawan","first_name":"M Pawan"}],"month":"06","quality_controlled":"1","arxiv":1,"date_published":"2018-06-28T00:00:00Z","conference":{"start_date":"2018-06-18","end_date":"2018-06-22","location":"Salt Lake City, UT, USA","name":"CVPR: Conference on Computer Vision and Pattern Recognition"},"external_id":{"arxiv":["1604.08269"],"isi":["000457843603087"]},"publication":"2018 IEEE/CVF Conference on Computer Vision and Pattern Recognition","publication_status":"published","article_processing_charge":"No","project":[{"_id":"25FBA906-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","grant_number":"616160","name":"Discrete Optimization in Computer Vision: Theory and Practice"}],"oa_version":"Preprint","year":"2018","doi":"10.1109/cvpr.2018.00389"},{"acknowledgement":"M. Brown was supported by the Cell Communication in Health and Disease Graduate Study Program of the Austrian Science Fund and Medizinische Universität Wien, M. Sixt by the European Research Council (ERC GA 281556) and an Austrian Science Fund START award, K.L. Bennett by the Austrian Academy of Sciences, D.G. Jackson and L.A. Johnson by Unit Funding (MC_UU_12010/2) and project grants from the Medical Research Council (G1100134 and MR/L008610/1), and M. Detmar by the Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung and Advanced European Research Council grant LYVICAM. K. Vaahtomeri was supported by an Academy of Finland postdoctoral research grant (287853). This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No. 668036 (RELENT).","pmid":1,"date_published":"2018-04-12T00:00:00Z","external_id":{"pmid":["29650776"],"isi":["000438077800026"]},"publication":"Journal of Cell Biology","author":[{"id":"3DAB9AFC-F248-11E8-B48F-1D18A9856A87","last_name":"Brown","first_name":"Markus","full_name":"Brown, Markus"},{"last_name":"Johnson","first_name":"Louise","full_name":"Johnson, Louise"},{"first_name":"Dario","full_name":"Leone, Dario","last_name":"Leone"},{"last_name":"Májek","first_name":"Peter","full_name":"Májek, Peter"},{"id":"368EE576-F248-11E8-B48F-1D18A9856A87","last_name":"Vaahtomeri","full_name":"Vaahtomeri, Kari","orcid":"0000-0001-7829-3518","first_name":"Kari"},{"full_name":"Senfter, Daniel","first_name":"Daniel","last_name":"Senfter"},{"full_name":"Bukosza, Nora","first_name":"Nora","last_name":"Bukosza"},{"last_name":"Schachner","full_name":"Schachner, Helga","first_name":"Helga"},{"full_name":"Asfour, Gabriele","first_name":"Gabriele","last_name":"Asfour"},{"full_name":"Langer, Brigitte","first_name":"Brigitte","last_name":"Langer"},{"id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87","last_name":"Hauschild","first_name":"Robert","full_name":"Hauschild, Robert","orcid":"0000-0001-9843-3522"},{"last_name":"Parapatics","first_name":"Katja","full_name":"Parapatics, Katja"},{"last_name":"Hong","full_name":"Hong, Young","first_name":"Young"},{"last_name":"Bennett","first_name":"Keiryn","full_name":"Bennett, Keiryn"},{"last_name":"Kain","first_name":"Renate","full_name":"Kain, Renate"},{"first_name":"Michael","full_name":"Detmar, Michael","last_name":"Detmar"},{"last_name":"Sixt","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","full_name":"Sixt, Michael K","orcid":"0000-0002-6620-9179","first_name":"Michael K"},{"full_name":"Jackson, David","first_name":"David","last_name":"Jackson"},{"full_name":"Kerjaschki, Dontscho","first_name":"Dontscho","last_name":"Kerjaschki"}],"intvolume":"       217","month":"04","quality_controlled":"1","ddc":["570"],"year":"2018","doi":"10.1083/jcb.201612051","file":[{"creator":"dernst","file_name":"2018_JournalCellBiology_Brown.pdf","date_created":"2018-12-17T12:50:07Z","access_level":"open_access","relation":"main_file","date_updated":"2020-07-14T12:45:45Z","content_type":"application/pdf","file_id":"5704","file_size":2252043,"checksum":"9c7eba51a35c62da8c13f98120b64df4"}],"has_accepted_license":"1","publication_status":"published","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"article_processing_charge":"No","project":[{"name":"Cytoskeletal force generation and transduction of leukocytes (FWF)","grant_number":"Y 564-B12","call_identifier":"FWF","_id":"25A8E5EA-B435-11E9-9278-68D0E5697425"},{"name":"Cytoskeletal force generation and force transduction of migrating leukocytes (EU)","grant_number":"281556","call_identifier":"FP7","_id":"25A603A2-B435-11E9-9278-68D0E5697425"}],"oa_version":"Published Version","date_created":"2018-12-11T11:45:33Z","abstract":[{"lang":"eng","text":"Lymphatic endothelial cells (LECs) release extracellular chemokines to guide the migration of dendritic cells. In this study, we report that LECs also release basolateral exosome-rich endothelial vesicles (EEVs) that are secreted in greater numbers in the presence of inflammatory cytokines and accumulate in the perivascular stroma of small lymphatic vessels in human chronic inflammatory diseases. Proteomic analyses of EEV fractions identified &gt; 1,700 cargo proteins and revealed a dominant motility-promoting protein signature. In vitro and ex vivo EEV fractions augmented cellular protrusion formation in a CX3CL1/fractalkine-dependent fashion and enhanced the directional migratory response of human dendritic cells along guidance cues. We conclude that perilymphatic LEC exosomes enhance exploratory behavior and thus promote directional migration of CX3CR1-expressing cells in complex tissue environments."}],"volume":217,"language":[{"iso":"eng"}],"oa":1,"isi":1,"date_updated":"2023-09-13T08:51:29Z","_id":"275","publisher":"Rockefeller University Press","day":"12","citation":{"apa":"Brown, M., Johnson, L., Leone, D., Májek, P., Vaahtomeri, K., Senfter, D., … Kerjaschki, D. (2018). Lymphatic exosomes promote dendritic cell migration along guidance cues. <i>Journal of Cell Biology</i>. Rockefeller University Press. <a href=\"https://doi.org/10.1083/jcb.201612051\">https://doi.org/10.1083/jcb.201612051</a>","ama":"Brown M, Johnson L, Leone D, et al. Lymphatic exosomes promote dendritic cell migration along guidance cues. <i>Journal of Cell Biology</i>. 2018;217(6):2205-2221. doi:<a href=\"https://doi.org/10.1083/jcb.201612051\">10.1083/jcb.201612051</a>","short":"M. Brown, L. Johnson, D. Leone, P. Májek, K. Vaahtomeri, D. Senfter, N. Bukosza, H. Schachner, G. Asfour, B. Langer, R. Hauschild, K. Parapatics, Y. Hong, K. Bennett, R. Kain, M. Detmar, M.K. Sixt, D. Jackson, D. Kerjaschki, Journal of Cell Biology 217 (2018) 2205–2221.","ista":"Brown M, Johnson L, Leone D, Májek P, Vaahtomeri K, Senfter D, Bukosza N, Schachner H, Asfour G, Langer B, Hauschild R, Parapatics K, Hong Y, Bennett K, Kain R, Detmar M, Sixt MK, Jackson D, Kerjaschki D. 2018. Lymphatic exosomes promote dendritic cell migration along guidance cues. Journal of Cell Biology. 217(6), 2205–2221.","mla":"Brown, Markus, et al. “Lymphatic Exosomes Promote Dendritic Cell Migration along Guidance Cues.” <i>Journal of Cell Biology</i>, vol. 217, no. 6, Rockefeller University Press, 2018, pp. 2205–21, doi:<a href=\"https://doi.org/10.1083/jcb.201612051\">10.1083/jcb.201612051</a>.","chicago":"Brown, Markus, Louise Johnson, Dario Leone, Peter Májek, Kari Vaahtomeri, Daniel Senfter, Nora Bukosza, et al. “Lymphatic Exosomes Promote Dendritic Cell Migration along Guidance Cues.” <i>Journal of Cell Biology</i>. Rockefeller University Press, 2018. <a href=\"https://doi.org/10.1083/jcb.201612051\">https://doi.org/10.1083/jcb.201612051</a>.","ieee":"M. Brown <i>et al.</i>, “Lymphatic exosomes promote dendritic cell migration along guidance cues,” <i>Journal of Cell Biology</i>, vol. 217, no. 6. Rockefeller University Press, pp. 2205–2221, 2018."},"department":[{"_id":"MiSi"},{"_id":"Bio"}],"page":"2205 - 2221","title":"Lymphatic exosomes promote dendritic cell migration along guidance cues","status":"public","scopus_import":"1","type":"journal_article","publist_id":"7627","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","file_date_updated":"2020-07-14T12:45:45Z","ec_funded":1,"issue":"6"},{"issue":"6","file_date_updated":"2020-07-14T12:45:45Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","publist_id":"7626","type":"journal_article","status":"public","scopus_import":"1","title":"Nano-scale microfluidics to study 3D chemotaxis at the single cell level","department":[{"_id":"MiSi"}],"citation":{"ieee":"C. Frick <i>et al.</i>, “Nano-scale microfluidics to study 3D chemotaxis at the single cell level,” <i>PLoS One</i>, vol. 13, no. 6. Public Library of Science, 2018.","mla":"Frick, Corina, et al. “Nano-Scale Microfluidics to Study 3D Chemotaxis at the Single Cell Level.” <i>PLoS One</i>, vol. 13, no. 6, e0198330, Public Library of Science, 2018, doi:<a href=\"https://doi.org/10.1371/journal.pone.0198330\">10.1371/journal.pone.0198330</a>.","ista":"Frick C, Dettinger P, Renkawitz J, Jauch A, Berger C, Recher M, Schroeder T, Mehling M. 2018. Nano-scale microfluidics to study 3D chemotaxis at the single cell level. PLoS One. 13(6), e0198330.","chicago":"Frick, Corina, Philip Dettinger, Jörg Renkawitz, Annaïse Jauch, Christoph Berger, Mike Recher, Timm Schroeder, and Matthias Mehling. “Nano-Scale Microfluidics to Study 3D Chemotaxis at the Single Cell Level.” <i>PLoS One</i>. Public Library of Science, 2018. <a href=\"https://doi.org/10.1371/journal.pone.0198330\">https://doi.org/10.1371/journal.pone.0198330</a>.","ama":"Frick C, Dettinger P, Renkawitz J, et al. Nano-scale microfluidics to study 3D chemotaxis at the single cell level. <i>PLoS One</i>. 2018;13(6). doi:<a href=\"https://doi.org/10.1371/journal.pone.0198330\">10.1371/journal.pone.0198330</a>","apa":"Frick, C., Dettinger, P., Renkawitz, J., Jauch, A., Berger, C., Recher, M., … Mehling, M. (2018). Nano-scale microfluidics to study 3D chemotaxis at the single cell level. <i>PLoS One</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pone.0198330\">https://doi.org/10.1371/journal.pone.0198330</a>","short":"C. Frick, P. Dettinger, J. Renkawitz, A. Jauch, C. Berger, M. Recher, T. Schroeder, M. Mehling, PLoS One 13 (2018)."},"publisher":"Public Library of Science","_id":"276","day":"07","date_updated":"2023-09-13T09:00:15Z","article_type":"original","oa":1,"isi":1,"language":[{"iso":"eng"}],"volume":13,"abstract":[{"text":"Directed migration of cells relies on their ability to sense directional guidance cues and to interact with pericellular structures in order to transduce contractile cytoskeletal- into mechanical forces. These biomechanical processes depend highly on microenvironmental factors such as exposure to 2D surfaces or 3D matrices. In vivo, the majority of cells are exposed to 3D environments. Data on 3D cell migration are mostly derived from intravital microscopy or collagen-based in vitro assays. Both approaches offer only limited controlla-bility of experimental conditions. Here, we developed an automated microfluidic system that allows positioning of cells in 3D microenvironments containing highly controlled diffusion-based chemokine gradients. Tracking migration in such gradients was feasible in real time at the single cell level. Moreover, the setup allowed on-chip immunocytochemistry and thus linking of functional with phenotypical properties in individual cells. Spatially defined retrieval of cells from the device allows down-stream off-chip analysis. Using dendritic cells as a model, our setup specifically allowed us for the first time to quantitate key migration characteristics of cells exposed to identical gradients of the chemokine CCL19 yet placed on 2D vs in 3D environments. Migration properties between 2D and 3D migration were distinct. Morphological features of cells migrating in an in vitro 3D environment were similar to those of cells migrating in animal tissues, but different from cells migrating on a surface. Our system thus offers a highly controllable in vitro-mimic of a 3D environment that cells traffic in vivo.","lang":"eng"}],"date_created":"2018-12-11T11:45:34Z","oa_version":"Published Version","article_processing_charge":"No","publication_status":"published","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"doi":"10.1371/journal.pone.0198330","has_accepted_license":"1","file":[{"checksum":"95fc5dc3938b3ad3b7697d10c83cc143","file_size":7682167,"access_level":"open_access","file_name":"2018_Plos_Frick.pdf","date_created":"2018-12-17T14:10:32Z","creator":"dernst","content_type":"application/pdf","date_updated":"2020-07-14T12:45:45Z","file_id":"5709","relation":"main_file"}],"year":"2018","ddc":["570"],"quality_controlled":"1","article_number":"e0198330","month":"06","intvolume":"        13","author":[{"first_name":"Corina","full_name":"Frick, Corina","last_name":"Frick"},{"last_name":"Dettinger","full_name":"Dettinger, Philip","first_name":"Philip"},{"last_name":"Renkawitz","id":"3F0587C8-F248-11E8-B48F-1D18A9856A87","first_name":"Jörg","orcid":"0000-0003-2856-3369","full_name":"Renkawitz, Jörg"},{"last_name":"Jauch","full_name":"Jauch, Annaïse","first_name":"Annaïse"},{"first_name":"Christoph","full_name":"Berger, Christoph","last_name":"Berger"},{"last_name":"Recher","first_name":"Mike","full_name":"Recher, Mike"},{"last_name":"Schroeder","first_name":"Timm","full_name":"Schroeder, Timm"},{"last_name":"Mehling","full_name":"Mehling, Matthias","first_name":"Matthias"}],"publication":"PLoS One","external_id":{"isi":["000434384900031"]},"date_published":"2018-06-07T00:00:00Z","acknowledgement":"This work was supported by the Swiss National Science Foundation (MD-PhD fellowships, 323530_164221 to C.F.; and 323630_151483 to A.J.; grant PZ00P3_144863 to M.R, grant 31003A_156431 to T.S.; PZ00P3_148000 to C.T.B.; PZ00P3_154733 to M.M.), a Novartis “FreeNovation” grant to M.M. and T.S. and an EMBO long-term fellowship (ALTF 1396-2014) co-funded by the European Commission (LTFCOFUND2013, GA-2013-609409) to J.R.. M.R. was supported by the Gebert Rüf Foundation (GRS 058/14). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."}]