[{"_id":"7219","scopus_import":"1","external_id":{"isi":["000508637500001"],"pmid":["31843370"]},"type":"journal_article","author":[{"first_name":"Guanghui","full_name":"Xiao, Guanghui","last_name":"Xiao"},{"orcid":"0000-0003-2627-6956","id":"3B6137F2-F248-11E8-B48F-1D18A9856A87","first_name":"Yuzhou","full_name":"Zhang, Yuzhou","last_name":"Zhang"}],"citation":{"chicago":"Xiao, Guanghui, and Yuzhou Zhang. “Adaptive Growth: Shaping Auxin-Mediated Root System Architecture.” <i>Trends in Plant Science</i>. Elsevier, 2020. <a href=\"https://doi.org/10.1016/j.tplants.2019.12.001\">https://doi.org/10.1016/j.tplants.2019.12.001</a>.","short":"G. Xiao, Y. Zhang, Trends in Plant Science 25 (2020) P121-123.","ama":"Xiao G, Zhang Y. Adaptive growth: Shaping auxin-mediated root system architecture. <i>Trends in Plant Science</i>. 2020;25(2):P121-123. doi:<a href=\"https://doi.org/10.1016/j.tplants.2019.12.001\">10.1016/j.tplants.2019.12.001</a>","ieee":"G. Xiao and Y. Zhang, “Adaptive growth: Shaping auxin-mediated root system architecture,” <i>Trends in Plant Science</i>, vol. 25, no. 2. Elsevier, pp. P121-123, 2020.","mla":"Xiao, Guanghui, and Yuzhou Zhang. “Adaptive Growth: Shaping Auxin-Mediated Root System Architecture.” <i>Trends in Plant Science</i>, vol. 25, no. 2, Elsevier, 2020, pp. P121-123, doi:<a href=\"https://doi.org/10.1016/j.tplants.2019.12.001\">10.1016/j.tplants.2019.12.001</a>.","apa":"Xiao, G., &#38; Zhang, Y. (2020). Adaptive growth: Shaping auxin-mediated root system architecture. <i>Trends in Plant Science</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.tplants.2019.12.001\">https://doi.org/10.1016/j.tplants.2019.12.001</a>","ista":"Xiao G, Zhang Y. 2020. Adaptive growth: Shaping auxin-mediated root system architecture. Trends in Plant Science. 25(2), P121-123."},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","department":[{"_id":"JiFr"}],"date_updated":"2023-08-17T14:14:50Z","oa_version":"None","quality_controlled":"1","title":"Adaptive growth: Shaping auxin-mediated root system architecture","date_published":"2020-02-01T00:00:00Z","date_created":"2019-12-29T23:00:48Z","article_processing_charge":"No","volume":25,"publication":"Trends in Plant Science","year":"2020","publication_identifier":{"issn":["13601385"]},"status":"public","pmid":1,"doi":"10.1016/j.tplants.2019.12.001","abstract":[{"text":"Root system architecture (RSA), governed by the phytohormone auxin, endows plants with an adaptive advantage in particular environments. Using geographically representative arabidopsis (Arabidopsis thaliana) accessions as a resource for GWA mapping, Waidmann et al. and Ogura et al. recently identified two novel components involved in modulating auxin-mediated RSA and conferring plant fitness in particular habitats.","lang":"eng"}],"issue":"2","month":"02","isi":1,"day":"01","publication_status":"published","publisher":"Elsevier","article_type":"original","page":"P121-123","intvolume":"        25","language":[{"iso":"eng"}]},{"oa_version":"None","date_updated":"2023-08-17T14:14:23Z","department":[{"_id":"BeBi"}],"citation":{"mla":"Dodier, Philippe, et al. “Novel Software-Derived Workflow in Extracranial–Intracranial Bypass Surgery Validated by Transdural Indocyanine Green Videoangiography.” <i>World Neurosurgery</i>, vol. 134, no. 2, Elsevier, 2020, pp. e892–902, doi:<a href=\"https://doi.org/10.1016/j.wneu.2019.11.038\">10.1016/j.wneu.2019.11.038</a>.","apa":"Dodier, P., Auzinger, T., Mistelbauer, G., Wang, W. T., Ferraz-Leite, H., Gruber, A., … Bavinzski, G. (2020). Novel software-derived workflow in extracranial–intracranial bypass surgery validated by transdural indocyanine green videoangiography. <i>World Neurosurgery</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.wneu.2019.11.038\">https://doi.org/10.1016/j.wneu.2019.11.038</a>","ista":"Dodier P, Auzinger T, Mistelbauer G, Wang WT, Ferraz-Leite H, Gruber A, Marik W, Winter F, Fischer G, Frischer JM, Bavinzski G. 2020. Novel software-derived workflow in extracranial–intracranial bypass surgery validated by transdural indocyanine green videoangiography. World Neurosurgery. 134(2), e892–e902.","chicago":"Dodier, Philippe, Thomas Auzinger, Gabriel Mistelbauer, Wei Te Wang, Heber Ferraz-Leite, Andreas Gruber, Wolfgang Marik, et al. “Novel Software-Derived Workflow in Extracranial–Intracranial Bypass Surgery Validated by Transdural Indocyanine Green Videoangiography.” <i>World Neurosurgery</i>. Elsevier, 2020. <a href=\"https://doi.org/10.1016/j.wneu.2019.11.038\">https://doi.org/10.1016/j.wneu.2019.11.038</a>.","short":"P. Dodier, T. Auzinger, G. Mistelbauer, W.T. Wang, H. Ferraz-Leite, A. Gruber, W. Marik, F. Winter, G. Fischer, J.M. Frischer, G. Bavinzski, World Neurosurgery 134 (2020) e892–e902.","ama":"Dodier P, Auzinger T, Mistelbauer G, et al. Novel software-derived workflow in extracranial–intracranial bypass surgery validated by transdural indocyanine green videoangiography. <i>World Neurosurgery</i>. 2020;134(2):e892-e902. doi:<a href=\"https://doi.org/10.1016/j.wneu.2019.11.038\">10.1016/j.wneu.2019.11.038</a>","ieee":"P. Dodier <i>et al.</i>, “Novel software-derived workflow in extracranial–intracranial bypass surgery validated by transdural indocyanine green videoangiography,” <i>World Neurosurgery</i>, vol. 134, no. 2. Elsevier, pp. e892–e902, 2020."},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","author":[{"last_name":"Dodier","first_name":"Philippe","full_name":"Dodier, Philippe"},{"last_name":"Auzinger","orcid":"0000-0002-1546-3265","first_name":"Thomas","full_name":"Auzinger, Thomas","id":"4718F954-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Mistelbauer","full_name":"Mistelbauer, Gabriel","first_name":"Gabriel"},{"full_name":"Wang, Wei Te","first_name":"Wei Te","last_name":"Wang"},{"first_name":"Heber","full_name":"Ferraz-Leite, Heber","last_name":"Ferraz-Leite"},{"last_name":"Gruber","full_name":"Gruber, Andreas","first_name":"Andreas"},{"last_name":"Marik","first_name":"Wolfgang","full_name":"Marik, Wolfgang"},{"full_name":"Winter, Fabian","first_name":"Fabian","last_name":"Winter"},{"last_name":"Fischer","first_name":"Gerrit","full_name":"Fischer, Gerrit"},{"first_name":"Josa M.","full_name":"Frischer, Josa M.","last_name":"Frischer"},{"last_name":"Bavinzski","first_name":"Gerhard","full_name":"Bavinzski, Gerhard"}],"type":"journal_article","external_id":{"isi":["000512878200104"],"pmid":["31733380"]},"scopus_import":"1","_id":"7220","year":"2020","publication":"World Neurosurgery","volume":134,"article_processing_charge":"No","date_created":"2019-12-29T23:00:48Z","title":"Novel software-derived workflow in extracranial–intracranial bypass surgery validated by transdural indocyanine green videoangiography","date_published":"2020-02-01T00:00:00Z","quality_controlled":"1","publication_status":"published","day":"01","isi":1,"month":"02","issue":"2","doi":"10.1016/j.wneu.2019.11.038","abstract":[{"lang":"eng","text":"BACKGROUND:The introduction of image-guided methods to bypass surgery has resulted in optimized preoperative identification of the recipients and excellent patency rates. However, the recently presented methods have also been resource-consuming. In the present study, we have reported a cost-efficient planning workflow for extracranial-intracranial (EC-IC) revascularization combined with transdural indocyanine green videoangiography (tICG-VA). METHODS:We performed a retrospective review at a single tertiary referral center from 2011 to 2018. A novel software-derived workflow was applied for 25 of 92 bypass procedures during the study period. The precision and accuracy were assessed using tICG-VA identification of the cortical recipients and a comparison of the virtual and actual data. The data from a control group of 25 traditionally planned procedures were also matched. RESULTS:The intraoperative transfer time of the calculated coordinates averaged 0.8 minute (range, 0.4-1.9 minutes). The definitive recipients matched the targeted branches in 80%, and a neighboring branch was used in 16%. Our workflow led to a significant craniotomy size reduction in the study group compared with that in the control group (P = 0.005). tICG-VA was successfully applied in 19 cases. An average of 2 potential recipient arteries were identified transdurally, resulting in tailored durotomy and 3 craniotomy adjustments. Follow-up patency results were available for 49 bypass surgeries, comprising 54 grafts. The overall patency rate was 91% at a median follow-up period of 26 months. No significant difference was found in the patency rate between the study and control groups (P = 0.317). CONCLUSIONS:Our clinical results have validated the presented planning and surgical workflow and support the routine implementation of tICG-VA for recipient identification before durotomy."}],"status":"public","pmid":1,"publication_identifier":{"eissn":["1878-8769"],"issn":["1878-8750"]},"language":[{"iso":"eng"}],"intvolume":"       134","article_type":"original","page":"e892-e902","publisher":"Elsevier"},{"isi":1,"month":"03","publication_status":"published","day":"01","ec_funded":1,"status":"public","publication_identifier":{"issn":["1461-023X"],"eissn":["1461-0248"]},"license":"https://creativecommons.org/licenses/by/4.0/","issue":"3","doi":"10.1111/ele.13450","abstract":[{"lang":"eng","text":"Habitat loss is one of the key drivers of the ongoing decline of biodiversity. However, ecologists still argue about how fragmentation of habitat (independent of habitat loss) affects species richness. The recently proposed habitat amount hypothesis posits that species richness only depends on the total amount of habitat in a local landscape. In contrast, empirical studies report contrasting patterns: some find positive and others negative effects of fragmentation per se on species richness. To explain this apparent disparity, we devise a stochastic, spatially explicit model of competitive species communities in heterogeneous habitats. The model shows that habitat loss and fragmentation have complex effects on species diversity in competitive communities. When the total amount of habitat is large, fragmentation per se tends to increase species diversity, but if the total amount of habitat is small, the situation is reversed: fragmentation per se decreases species diversity."}],"intvolume":"        23","article_type":"original","page":"506-517","language":[{"iso":"eng"}],"publisher":"Wiley","type":"journal_article","oa_version":"Published Version","date_updated":"2023-09-05T16:04:30Z","department":[{"_id":"DaAl"}],"file":[{"checksum":"372f67f2744f4b6049e9778364766c22","relation":"main_file","creator":"dernst","access_level":"open_access","file_id":"7486","date_created":"2020-02-14T12:02:50Z","file_name":"2020_EcologyLetters_Rybicki.pdf","content_type":"application/pdf","date_updated":"2020-07-14T12:47:54Z","file_size":3005474}],"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","citation":{"apa":"Rybicki, J., Abrego, N., &#38; Ovaskainen, O. (2020). Habitat fragmentation and species diversity in competitive communities. <i>Ecology Letters</i>. Wiley. <a href=\"https://doi.org/10.1111/ele.13450\">https://doi.org/10.1111/ele.13450</a>","mla":"Rybicki, Joel, et al. “Habitat Fragmentation and Species Diversity in Competitive Communities.” <i>Ecology Letters</i>, vol. 23, no. 3, Wiley, 2020, pp. 506–17, doi:<a href=\"https://doi.org/10.1111/ele.13450\">10.1111/ele.13450</a>.","ista":"Rybicki J, Abrego N, Ovaskainen O. 2020. Habitat fragmentation and species diversity in competitive communities. Ecology Letters. 23(3), 506–517.","chicago":"Rybicki, Joel, Nerea Abrego, and Otso Ovaskainen. “Habitat Fragmentation and Species Diversity in Competitive Communities.” <i>Ecology Letters</i>. Wiley, 2020. <a href=\"https://doi.org/10.1111/ele.13450\">https://doi.org/10.1111/ele.13450</a>.","ama":"Rybicki J, Abrego N, Ovaskainen O. Habitat fragmentation and species diversity in competitive communities. <i>Ecology Letters</i>. 2020;23(3):506-517. doi:<a href=\"https://doi.org/10.1111/ele.13450\">10.1111/ele.13450</a>","short":"J. Rybicki, N. Abrego, O. Ovaskainen, Ecology Letters 23 (2020) 506–517.","ieee":"J. Rybicki, N. Abrego, and O. Ovaskainen, “Habitat fragmentation and species diversity in competitive communities,” <i>Ecology Letters</i>, vol. 23, no. 3. Wiley, pp. 506–517, 2020."},"has_accepted_license":"1","author":[{"id":"334EFD2E-F248-11E8-B48F-1D18A9856A87","full_name":"Rybicki, Joel","first_name":"Joel","orcid":"0000-0002-6432-6646","last_name":"Rybicki"},{"last_name":"Abrego","first_name":"Nerea","full_name":"Abrego, Nerea"},{"full_name":"Ovaskainen, Otso","first_name":"Otso","last_name":"Ovaskainen"}],"oa":1,"_id":"7224","external_id":{"isi":["000503625200001"]},"file_date_updated":"2020-07-14T12:47:54Z","scopus_import":"1","ddc":["000"],"date_created":"2020-01-04T11:04:30Z","year":"2020","publication":"Ecology Letters","volume":23,"article_processing_charge":"Yes (via OA deal)","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"project":[{"_id":"260C2330-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"754411","name":"ISTplus - Postdoctoral Fellowships"},{"name":"Coordination in constrained and natural distributed systems","grant_number":"840605","_id":"26A5D39A-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"}],"title":"Habitat fragmentation and species diversity in competitive communities","date_published":"2020-03-01T00:00:00Z","quality_controlled":"1"},{"publisher":"Elsevier","language":[{"iso":"eng"}],"intvolume":"       136","page":"343-375","doi":"10.1016/bs.ctdb.2019.10.009","abstract":[{"text":"Gastrulation entails specification and formation of three embryonic germ layers—ectoderm, mesoderm and endoderm—thereby establishing the basis for the future body plan. In zebrafish embryos, germ layer specification occurs during blastula and early gastrula stages (Ho & Kimmel, 1993), a period when the main morphogenetic movements underlying gastrulation are initiated. Hence, the signals driving progenitor cell fate specification, such as Nodal ligands from the TGF-β family, also play key roles in regulating germ layer progenitor cell segregation (Carmany-Rampey & Schier, 2001; David & Rosa, 2001; Feldman et al., 2000; Gritsman et al., 1999; Keller et al., 2008). In this review, we summarize and discuss the main signaling pathways involved in germ layer progenitor cell fate specification and segregation, specifically focusing on recent advances in understanding the interplay between mesoderm and endoderm specification and the internalization movements at the onset of zebrafish gastrulation.","lang":"eng"}],"status":"public","pmid":1,"publication_identifier":{"issn":["00702153"]},"acknowledgement":"We thank Alexandra Schauer, Nicoletta Petridou and Feyza Nur Arslan for comments on the manuscript. Research in the Heisenberg laboratory is supported by an ERC Advanced Grant (MECSPEC 742573), ANR/FWF (I03601) and FWF/DFG (I03196) International Cooperation Grants. D. Pinheiro acknowledges a fellowship from EMBO ALTF (850-2017) and is currently supported by HFSP LTF (LT000429/2018-L2).","publication_status":"published","ec_funded":1,"day":"01","alternative_title":["Current Topics in Developmental Biology"],"month":"06","isi":1,"title":"Zebrafish gastrulation: Putting fate in motion","date_published":"2020-06-01T00:00:00Z","project":[{"call_identifier":"H2020","_id":"260F1432-B435-11E9-9278-68D0E5697425","grant_number":"742573","name":"Interaction and feedback between cell mechanics and fate specification in vertebrate gastrulation"},{"grant_number":"I03601","name":"Control of embryonic cleavage pattern","_id":"2646861A-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"},{"_id":"2608FC64-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","name":"Control of epithelial cell layer spreading in zebrafish","grant_number":"I03196"},{"name":"Coordination of mesendoderm fate specification and internalization during zebrafish gastrulation","grant_number":"LT000429","_id":"266BC5CE-B435-11E9-9278-68D0E5697425"},{"grant_number":"ALTF 850-2017","name":"Coordination of mesendoderm cell fate specification and internalization during zebrafish gastrulation","_id":"26520D1E-B435-11E9-9278-68D0E5697425"}],"quality_controlled":"1","year":"2020","article_processing_charge":"No","volume":136,"publication":"Gastrulation: From Embryonic Pattern to Form","date_created":"2020-01-05T23:00:46Z","external_id":{"pmid":["31959295"],"isi":["000611830600013"]},"scopus_import":"1","_id":"7227","department":[{"_id":"CaHe"}],"oa_version":"None","date_updated":"2023-09-06T14:54:36Z","author":[{"last_name":"Nunes Pinheiro","orcid":"0000-0003-4333-7503","id":"2E839F16-F248-11E8-B48F-1D18A9856A87","first_name":"Diana C","full_name":"Nunes Pinheiro, Diana C"},{"orcid":"0000-0002-0912-4566","id":"39427864-F248-11E8-B48F-1D18A9856A87","full_name":"Heisenberg, Carl-Philipp J","first_name":"Carl-Philipp J","last_name":"Heisenberg"}],"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","citation":{"chicago":"Nunes Pinheiro, Diana C, and Carl-Philipp J Heisenberg. “Zebrafish Gastrulation: Putting Fate in Motion.” In <i>Gastrulation: From Embryonic Pattern to Form</i>, 136:343–75. Elsevier, 2020. <a href=\"https://doi.org/10.1016/bs.ctdb.2019.10.009\">https://doi.org/10.1016/bs.ctdb.2019.10.009</a>.","short":"D.C. Nunes Pinheiro, C.-P.J. Heisenberg, in:, Gastrulation: From Embryonic Pattern to Form, Elsevier, 2020, pp. 343–375.","ama":"Nunes Pinheiro DC, Heisenberg C-PJ. Zebrafish gastrulation: Putting fate in motion. In: <i>Gastrulation: From Embryonic Pattern to Form</i>. Vol 136. Elsevier; 2020:343-375. doi:<a href=\"https://doi.org/10.1016/bs.ctdb.2019.10.009\">10.1016/bs.ctdb.2019.10.009</a>","ieee":"D. C. Nunes Pinheiro and C.-P. J. Heisenberg, “Zebrafish gastrulation: Putting fate in motion,” in <i>Gastrulation: From Embryonic Pattern to Form</i>, vol. 136, Elsevier, 2020, pp. 343–375.","apa":"Nunes Pinheiro, D. C., &#38; Heisenberg, C.-P. J. (2020). Zebrafish gastrulation: Putting fate in motion. In <i>Gastrulation: From Embryonic Pattern to Form</i> (Vol. 136, pp. 343–375). Elsevier. <a href=\"https://doi.org/10.1016/bs.ctdb.2019.10.009\">https://doi.org/10.1016/bs.ctdb.2019.10.009</a>","mla":"Nunes Pinheiro, Diana C., and Carl-Philipp J. Heisenberg. “Zebrafish Gastrulation: Putting Fate in Motion.” <i>Gastrulation: From Embryonic Pattern to Form</i>, vol. 136, Elsevier, 2020, pp. 343–75, doi:<a href=\"https://doi.org/10.1016/bs.ctdb.2019.10.009\">10.1016/bs.ctdb.2019.10.009</a>.","ista":"Nunes Pinheiro DC, Heisenberg C-PJ. 2020.Zebrafish gastrulation: Putting fate in motion. In: Gastrulation: From Embryonic Pattern to Form. Current Topics in Developmental Biology, vol. 136, 343–375."},"type":"book_chapter"},{"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"quality_controlled":"1","title":"Partial loss of actin nucleator actin-related protein 2/3 activity triggers blebbing in primary T lymphocytes","date_published":"2020-02-01T00:00:00Z","date_created":"2020-01-05T23:00:48Z","ddc":["570"],"article_processing_charge":"No","volume":98,"publication":"Immunology and Cell Biology","year":"2020","_id":"7234","scopus_import":"1","file_date_updated":"2020-11-19T11:22:33Z","external_id":{"isi":["000503885600001"],"pmid":["31698518"]},"type":"journal_article","oa":1,"author":[{"last_name":"Obeidy","full_name":"Obeidy, Peyman","first_name":"Peyman"},{"first_name":"Lining A.","full_name":"Ju, Lining A.","last_name":"Ju"},{"last_name":"Oehlers","full_name":"Oehlers, Stefan H.","first_name":"Stefan H."},{"last_name":"Zulkhernain","first_name":"Nursafwana S.","full_name":"Zulkhernain, Nursafwana S."},{"first_name":"Quintin","full_name":"Lee, Quintin","last_name":"Lee"},{"last_name":"Galeano Niño","full_name":"Galeano Niño, Jorge L.","first_name":"Jorge L."},{"first_name":"Rain Y.Q.","full_name":"Kwan, Rain Y.Q.","last_name":"Kwan"},{"first_name":"Shweta","full_name":"Tikoo, Shweta","last_name":"Tikoo"},{"last_name":"Cavanagh","first_name":"Lois L.","full_name":"Cavanagh, Lois L."},{"last_name":"Mrass","full_name":"Mrass, Paulus","first_name":"Paulus"},{"full_name":"Cook, Adam J.L.","first_name":"Adam J.L.","last_name":"Cook"},{"full_name":"Jackson, Shaun P.","first_name":"Shaun P.","last_name":"Jackson"},{"full_name":"Biro, Maté","first_name":"Maté","last_name":"Biro"},{"last_name":"Roediger","first_name":"Ben","full_name":"Roediger, Ben"},{"last_name":"Sixt","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","first_name":"Michael K","full_name":"Sixt, Michael K","orcid":"0000-0002-6620-9179"},{"last_name":"Weninger","first_name":"Wolfgang","full_name":"Weninger, Wolfgang"}],"has_accepted_license":"1","citation":{"ista":"Obeidy P, Ju LA, Oehlers SH, Zulkhernain NS, Lee Q, Galeano Niño JL, Kwan RYQ, Tikoo S, Cavanagh LL, Mrass P, Cook AJL, Jackson SP, Biro M, Roediger B, Sixt MK, Weninger W. 2020. Partial loss of actin nucleator actin-related protein 2/3 activity triggers blebbing in primary T lymphocytes. Immunology and Cell Biology. 98(2), 93–113.","apa":"Obeidy, P., Ju, L. A., Oehlers, S. H., Zulkhernain, N. S., Lee, Q., Galeano Niño, J. L., … Weninger, W. (2020). Partial loss of actin nucleator actin-related protein 2/3 activity triggers blebbing in primary T lymphocytes. <i>Immunology and Cell Biology</i>. Wiley. <a href=\"https://doi.org/10.1111/imcb.12304\">https://doi.org/10.1111/imcb.12304</a>","mla":"Obeidy, Peyman, et al. “Partial Loss of Actin Nucleator Actin-Related Protein 2/3 Activity Triggers Blebbing in Primary T Lymphocytes.” <i>Immunology and Cell Biology</i>, vol. 98, no. 2, Wiley, 2020, pp. 93–113, doi:<a href=\"https://doi.org/10.1111/imcb.12304\">10.1111/imcb.12304</a>.","short":"P. Obeidy, L.A. Ju, S.H. Oehlers, N.S. Zulkhernain, Q. Lee, J.L. Galeano Niño, R.Y.Q. Kwan, S. Tikoo, L.L. Cavanagh, P. Mrass, A.J.L. Cook, S.P. Jackson, M. Biro, B. Roediger, M.K. Sixt, W. Weninger, Immunology and Cell Biology 98 (2020) 93–113.","ama":"Obeidy P, Ju LA, Oehlers SH, et al. Partial loss of actin nucleator actin-related protein 2/3 activity triggers blebbing in primary T lymphocytes. <i>Immunology and Cell Biology</i>. 2020;98(2):93-113. doi:<a href=\"https://doi.org/10.1111/imcb.12304\">10.1111/imcb.12304</a>","chicago":"Obeidy, Peyman, Lining A. Ju, Stefan H. Oehlers, Nursafwana S. Zulkhernain, Quintin Lee, Jorge L. Galeano Niño, Rain Y.Q. Kwan, et al. “Partial Loss of Actin Nucleator Actin-Related Protein 2/3 Activity Triggers Blebbing in Primary T Lymphocytes.” <i>Immunology and Cell Biology</i>. Wiley, 2020. <a href=\"https://doi.org/10.1111/imcb.12304\">https://doi.org/10.1111/imcb.12304</a>.","ieee":"P. Obeidy <i>et al.</i>, “Partial loss of actin nucleator actin-related protein 2/3 activity triggers blebbing in primary T lymphocytes,” <i>Immunology and Cell Biology</i>, vol. 98, no. 2. Wiley, pp. 93–113, 2020."},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","file":[{"relation":"main_file","checksum":"c389477b4b52172ef76afff8a06c6775","creator":"dernst","access_level":"open_access","date_created":"2020-11-19T11:22:33Z","success":1,"file_id":"8775","file_name":"2020_ImmunologyCellBio_Obeidy.pdf","file_size":8569945,"date_updated":"2020-11-19T11:22:33Z","content_type":"application/pdf"}],"department":[{"_id":"MiSi"}],"date_updated":"2023-08-17T14:21:12Z","oa_version":"Published Version","publisher":"Wiley","page":"93-113","article_type":"original","intvolume":"        98","language":[{"iso":"eng"}],"publication_identifier":{"issn":["08189641"],"eissn":["14401711"]},"status":"public","pmid":1,"abstract":[{"lang":"eng","text":"T lymphocytes utilize amoeboid migration to navigate effectively within complex microenvironments. The precise rearrangement of the actin cytoskeleton required for cellular forward propulsion is mediated by actin regulators, including the actin‐related protein 2/3 (Arp2/3) complex, a macromolecular machine that nucleates branched actin filaments at the leading edge. The consequences of modulating Arp2/3 activity on the biophysical properties of the actomyosin cortex and downstream T cell function are incompletely understood. We report that even a moderate decrease of Arp3 levels in T cells profoundly affects actin cortex integrity. Reduction in total F‐actin content leads to reduced cortical tension and disrupted lamellipodia formation. Instead, in Arp3‐knockdown cells, the motility mode is dominated by blebbing migration characterized by transient, balloon‐like protrusions at the leading edge. Although this migration mode seems to be compatible with interstitial migration in three‐dimensional environments, diminished locomotion kinetics and impaired cytotoxicity interfere with optimal T cell function. These findings define the importance of finely tuned, Arp2/3‐dependent mechanophysical membrane integrity in cytotoxic effector T lymphocyte activities."}],"doi":"10.1111/imcb.12304","issue":"2","month":"02","isi":1,"day":"01","publication_status":"published"},{"page":"23-33","article_type":"original","intvolume":"       180","language":[{"iso":"eng"}],"publisher":"Springer Nature","month":"09","isi":1,"ec_funded":1,"day":"01","acknowledgement":"Open access funding provided by Institute of Science and Technology (IST Austria). Financial support through the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant Agreement No. 694227; R.S.) is gratefully acknowledged.","publication_status":"published","publication_identifier":{"issn":["0022-4715"],"eissn":["1572-9613"]},"status":"public","doi":"10.1007/s10955-019-02322-3","abstract":[{"text":"We consider the Fröhlich model of a polaron, and show that its effective mass diverges in thestrong coupling limit.","lang":"eng"}],"date_created":"2020-01-07T09:42:03Z","ddc":["510","530"],"volume":180,"article_processing_charge":"Yes (via OA deal)","publication":"Journal of Statistical Physics","year":"2020","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"quality_controlled":"1","date_published":"2020-09-01T00:00:00Z","title":"Divergence of the effective mass of a polaron in the strong coupling limit","project":[{"_id":"B67AFEDC-15C9-11EA-A837-991A96BB2854","name":"IST Austria Open Access Fund"},{"grant_number":"694227","name":"Analysis of quantum many-body systems","call_identifier":"H2020","_id":"25C6DC12-B435-11E9-9278-68D0E5697425"}],"type":"journal_article","author":[{"last_name":"Lieb","full_name":"Lieb, Elliott H.","first_name":"Elliott H."},{"last_name":"Seiringer","full_name":"Seiringer, Robert","first_name":"Robert","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6781-0521"}],"oa":1,"has_accepted_license":"1","citation":{"short":"E.H. Lieb, R. Seiringer, Journal of Statistical Physics 180 (2020) 23–33.","ama":"Lieb EH, Seiringer R. Divergence of the effective mass of a polaron in the strong coupling limit. <i>Journal of Statistical Physics</i>. 2020;180:23-33. doi:<a href=\"https://doi.org/10.1007/s10955-019-02322-3\">10.1007/s10955-019-02322-3</a>","chicago":"Lieb, Elliott H., and Robert Seiringer. “Divergence of the Effective Mass of a Polaron in the Strong Coupling Limit.” <i>Journal of Statistical Physics</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1007/s10955-019-02322-3\">https://doi.org/10.1007/s10955-019-02322-3</a>.","ieee":"E. H. Lieb and R. Seiringer, “Divergence of the effective mass of a polaron in the strong coupling limit,” <i>Journal of Statistical Physics</i>, vol. 180. Springer Nature, pp. 23–33, 2020.","ista":"Lieb EH, Seiringer R. 2020. Divergence of the effective mass of a polaron in the strong coupling limit. Journal of Statistical Physics. 180, 23–33.","mla":"Lieb, Elliott H., and Robert Seiringer. “Divergence of the Effective Mass of a Polaron in the Strong Coupling Limit.” <i>Journal of Statistical Physics</i>, vol. 180, Springer Nature, 2020, pp. 23–33, doi:<a href=\"https://doi.org/10.1007/s10955-019-02322-3\">10.1007/s10955-019-02322-3</a>.","apa":"Lieb, E. H., &#38; Seiringer, R. (2020). Divergence of the effective mass of a polaron in the strong coupling limit. <i>Journal of Statistical Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s10955-019-02322-3\">https://doi.org/10.1007/s10955-019-02322-3</a>"},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","file":[{"creator":"dernst","relation":"main_file","checksum":"1e67bee6728592f7bdcea2ad2d9366dc","success":1,"date_created":"2020-11-19T11:13:55Z","file_id":"8774","access_level":"open_access","file_size":279749,"content_type":"application/pdf","date_updated":"2020-11-19T11:13:55Z","file_name":"2020_JourStatPhysics_Lieb.pdf"}],"department":[{"_id":"RoSe"}],"date_updated":"2023-09-05T14:57:29Z","oa_version":"Published Version","_id":"7235","scopus_import":"1","file_date_updated":"2020-11-19T11:13:55Z","external_id":{"isi":["000556199700003"]}},{"type":"journal_article","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","has_accepted_license":"1","citation":{"apa":"Baskett, C., Schroeder, L., Weber, M. G., &#38; Schemske, D. W. (2020). Multiple metrics of latitudinal patterns in insect pollination and herbivory for a tropical‐temperate congener pair. <i>Ecological Monographs</i>. Wiley. <a href=\"https://doi.org/10.1002/ecm.1397\">https://doi.org/10.1002/ecm.1397</a>","mla":"Baskett, Carina, et al. “Multiple Metrics of Latitudinal Patterns in Insect Pollination and Herbivory for a Tropical‐temperate Congener Pair.” <i>Ecological Monographs</i>, vol. 90, no. 1, e01397, Wiley, 2020, doi:<a href=\"https://doi.org/10.1002/ecm.1397\">10.1002/ecm.1397</a>.","ista":"Baskett C, Schroeder L, Weber MG, Schemske DW. 2020. Multiple metrics of latitudinal patterns in insect pollination and herbivory for a tropical‐temperate congener pair. Ecological Monographs. 90(1), e01397.","chicago":"Baskett, Carina, Lucy Schroeder, Marjorie G. Weber, and Douglas W. Schemske. “Multiple Metrics of Latitudinal Patterns in Insect Pollination and Herbivory for a Tropical‐temperate Congener Pair.” <i>Ecological Monographs</i>. Wiley, 2020. <a href=\"https://doi.org/10.1002/ecm.1397\">https://doi.org/10.1002/ecm.1397</a>.","ama":"Baskett C, Schroeder L, Weber MG, Schemske DW. Multiple metrics of latitudinal patterns in insect pollination and herbivory for a tropical‐temperate congener pair. <i>Ecological Monographs</i>. 2020;90(1). doi:<a href=\"https://doi.org/10.1002/ecm.1397\">10.1002/ecm.1397</a>","short":"C. Baskett, L. Schroeder, M.G. Weber, D.W. Schemske, Ecological Monographs 90 (2020).","ieee":"C. Baskett, L. Schroeder, M. G. Weber, and D. W. Schemske, “Multiple metrics of latitudinal patterns in insect pollination and herbivory for a tropical‐temperate congener pair,” <i>Ecological Monographs</i>, vol. 90, no. 1. Wiley, 2020."},"oa":1,"author":[{"last_name":"Baskett","orcid":"0000-0002-7354-8574","full_name":"Baskett, Carina","id":"3B4A7CE2-F248-11E8-B48F-1D18A9856A87","first_name":"Carina"},{"full_name":"Schroeder, Lucy","first_name":"Lucy","last_name":"Schroeder"},{"first_name":"Marjorie G.","full_name":"Weber, Marjorie G.","last_name":"Weber"},{"full_name":"Schemske, Douglas W.","first_name":"Douglas W.","last_name":"Schemske"}],"oa_version":"Published Version","date_updated":"2023-09-05T15:43:19Z","file":[{"access_level":"open_access","date_created":"2020-02-10T08:18:14Z","file_id":"7469","file_name":"2020_EcologMono_Baskett.pdf","file_size":537941,"content_type":"application/pdf","date_updated":"2020-07-14T12:47:54Z","relation":"main_file","checksum":"ab8130c6e68101f5a091d05324c36f08","creator":"dernst"}],"department":[{"_id":"NiBa"}],"_id":"7236","file_date_updated":"2020-07-14T12:47:54Z","scopus_import":"1","external_id":{"isi":["000508511600001"]},"ddc":["570"],"date_created":"2020-01-07T12:47:07Z","publication":"Ecological Monographs","volume":90,"article_processing_charge":"Yes (via OA deal)","year":"2020","tmp":{"image":"/images/cc_by_nc.png","short":"CC BY-NC (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)"},"quality_controlled":"1","project":[{"name":"ISTplus - Postdoctoral Fellowships","grant_number":"754411","call_identifier":"H2020","_id":"260C2330-B435-11E9-9278-68D0E5697425"}],"title":"Multiple metrics of latitudinal patterns in insect pollination and herbivory for a tropical‐temperate congener pair","date_published":"2020-02-01T00:00:00Z","isi":1,"month":"02","day":"01","ec_funded":1,"publication_status":"published","publication_identifier":{"eissn":["1557-7015"],"issn":["0012-9615"]},"status":"public","abstract":[{"lang":"eng","text":"The biotic interactions hypothesis posits that biotic interactions are more important drivers of adaptation closer to the equator, evidenced by “stronger” contemporary interactions (e.g. greater interaction rates) and/or patterns of trait evolution consistent with a history of stronger interactions. Support for the hypothesis is mixed, but few studies span tropical and temperate regions while experimentally controlling for evolutionary history. Here, we integrate field observations and common garden experiments to quantify the relative importance of pollination and herbivory in a pair of tropical‐temperate congeneric perennial herbs. Phytolacca rivinoides and P. americana are pioneer species native to the Neotropics and the eastern USA, respectively. We compared plant‐pollinator and plant‐herbivore interactions between three tropical populations of P. rivinoides from Costa Rica and three temperate populations of P. americana from its northern range edge in Michigan and Ohio. For some metrics of interaction importance, we also included three subtropical populations of P. americana from its southern range edge in Florida. This approach confounds species and region but allows us, uniquely, to measure complementary proxies of interaction importance across a tropical‐temperate range in one system. To test the prediction that lower‐latitude plants are more reliant on insect pollinators, we quantified floral display and reward, insect visitation rates, and self‐pollination ability (autogamy). To test the prediction that lower‐latitude plants experience more herbivore pressure, we quantified herbivory rates, herbivore abundance, and leaf palatability. We found evidence supporting the biotic interactions hypothesis for most comparisons between P. rivinoides and north‐temperate P. americana (floral display, insect visitation, autogamy, herbivory, herbivore abundance, and young‐leaf palatability). Results for subtropical P. americana populations, however, were typically not intermediate between P. rivinoides and north‐temperate P. americana, as would be predicted by a linear latitudinal gradient in interaction importance. Subtropical young‐leaf palatability was intermediate, but subtropical mature leaves were the least palatable, and pollination‐related traits did not differ between temperate and subtropical regions. These nonlinear patterns of interaction importance suggest future work to relate interaction importance to climatic or biotic thresholds. In sum, we found that the biotic interactions hypothesis was more consistently supported at the larger spatial scale of our study."}],"doi":"10.1002/ecm.1397","license":"https://creativecommons.org/licenses/by-nc/4.0/","issue":"1","article_type":"original","article_number":"e01397","intvolume":"        90","language":[{"iso":"eng"}],"publisher":"Wiley"},{"type":"journal_article","oa_version":"Published Version","date_updated":"2023-08-17T14:23:41Z","file":[{"file_id":"7261","date_created":"2020-01-13T07:42:31Z","access_level":"open_access","content_type":"application/pdf","date_updated":"2020-07-14T12:47:54Z","file_size":8063333,"file_name":"2020_NatureComm_Laukoter.pdf","creator":"dernst","checksum":"ebf1ed522f4e0be8d94c939c1806a709","relation":"main_file"}],"department":[{"_id":"SiHi"}],"has_accepted_license":"1","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","citation":{"chicago":"Laukoter, Susanne, Robert J Beattie, Florian Pauler, Nicole Amberg, Keiichi I. Nakayama, and Simon Hippenmeyer. “Imprinted Cdkn1c Genomic Locus Cell-Autonomously Promotes Cell Survival in Cerebral Cortex Development.” <i>Nature Communications</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41467-019-14077-2\">https://doi.org/10.1038/s41467-019-14077-2</a>.","short":"S. Laukoter, R.J. Beattie, F. Pauler, N. Amberg, K.I. Nakayama, S. Hippenmeyer, Nature Communications 11 (2020).","ama":"Laukoter S, Beattie RJ, Pauler F, Amberg N, Nakayama KI, Hippenmeyer S. Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development. <i>Nature Communications</i>. 2020;11. doi:<a href=\"https://doi.org/10.1038/s41467-019-14077-2\">10.1038/s41467-019-14077-2</a>","ieee":"S. Laukoter, R. J. Beattie, F. Pauler, N. Amberg, K. I. Nakayama, and S. Hippenmeyer, “Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development,” <i>Nature Communications</i>, vol. 11. Springer Nature, 2020.","apa":"Laukoter, S., Beattie, R. J., Pauler, F., Amberg, N., Nakayama, K. I., &#38; Hippenmeyer, S. (2020). Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-019-14077-2\">https://doi.org/10.1038/s41467-019-14077-2</a>","mla":"Laukoter, Susanne, et al. “Imprinted Cdkn1c Genomic Locus Cell-Autonomously Promotes Cell Survival in Cerebral Cortex Development.” <i>Nature Communications</i>, vol. 11, 195, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1038/s41467-019-14077-2\">10.1038/s41467-019-14077-2</a>.","ista":"Laukoter S, Beattie RJ, Pauler F, Amberg N, Nakayama KI, Hippenmeyer S. 2020. Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development. Nature Communications. 11, 195."},"oa":1,"author":[{"orcid":"0000-0002-7903-3010","full_name":"Laukoter, Susanne","id":"2D6B7A9A-F248-11E8-B48F-1D18A9856A87","first_name":"Susanne","last_name":"Laukoter"},{"orcid":"0000-0002-8483-8753","first_name":"Robert J","id":"2E26DF60-F248-11E8-B48F-1D18A9856A87","full_name":"Beattie, Robert J","last_name":"Beattie"},{"last_name":"Pauler","full_name":"Pauler, Florian","first_name":"Florian","id":"48EA0138-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-7462-0048"},{"last_name":"Amberg","first_name":"Nicole","id":"4CD6AAC6-F248-11E8-B48F-1D18A9856A87","full_name":"Amberg, Nicole","orcid":"0000-0002-3183-8207"},{"first_name":"Keiichi I.","full_name":"Nakayama, Keiichi I.","last_name":"Nakayama"},{"last_name":"Hippenmeyer","first_name":"Simon","id":"37B36620-F248-11E8-B48F-1D18A9856A87","full_name":"Hippenmeyer, Simon","orcid":"0000-0003-2279-1061"}],"_id":"7253","external_id":{"isi":["000551459000005"]},"file_date_updated":"2020-07-14T12:47:54Z","scopus_import":"1","ddc":["570"],"date_created":"2020-01-11T10:42:48Z","year":"2020","publication":"Nature Communications","article_processing_charge":"No","volume":11,"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"project":[{"name":"Role of Eed in neural stem cell lineage progression","grant_number":"T0101031","call_identifier":"FWF","_id":"268F8446-B435-11E9-9278-68D0E5697425"},{"name":"Molecular Mechanisms Regulating Gliogenesis in the Cerebral Cortex","grant_number":"M02416","call_identifier":"FWF","_id":"264E56E2-B435-11E9-9278-68D0E5697425"},{"name":"Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development","grant_number":"725780","call_identifier":"H2020","_id":"260018B0-B435-11E9-9278-68D0E5697425"},{"_id":"25D92700-B435-11E9-9278-68D0E5697425","name":"Mapping Cell-Type Specificity of the Genomic Imprintome in the Brain","grant_number":"LS13-002"}],"title":"Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development","date_published":"2020-01-10T00:00:00Z","quality_controlled":"1","isi":1,"related_material":{"link":[{"description":"News on IST Homepage","relation":"press_release","url":"https://ist.ac.at/en/news/new-function-for-potential-tumour-suppressor-in-brain-development/"}]},"month":"01","publication_status":"published","day":"10","ec_funded":1,"status":"public","publication_identifier":{"issn":["2041-1723"]},"acknowledged_ssus":[{"_id":"PreCl"}],"doi":"10.1038/s41467-019-14077-2","abstract":[{"lang":"eng","text":"The cyclin-dependent kinase inhibitor p57KIP2 is encoded by the imprinted Cdkn1c locus, exhibits maternal expression, and is essential for cerebral cortex development. How Cdkn1c regulates corticogenesis is however not clear. To this end we employ Mosaic Analysis with Double Markers (MADM) technology to genetically dissect Cdkn1c gene function in corticogenesis at single cell resolution. We find that the previously described growth-inhibitory Cdkn1c function is a non-cell-autonomous one, acting on the whole organism. In contrast we reveal a growth-promoting cell-autonomous Cdkn1c function which at the mechanistic level mediates radial glial progenitor cell and nascent projection neuron survival. Strikingly, the growth-promoting function of Cdkn1c is highly dosage sensitive but not subject to genomic imprinting. Collectively, our results suggest that the Cdkn1c locus regulates cortical development through distinct cell-autonomous and non-cell-autonomous mechanisms. More generally, our study highlights the importance to probe the relative contributions of cell intrinsic gene function and tissue-wide mechanisms to the overall phenotype."}],"article_number":"195","intvolume":"        11","article_type":"original","language":[{"iso":"eng"}],"publisher":"Springer Nature"},{"type":"dissertation","oa":1,"author":[{"last_name":"Scarselli","id":"40315C30-F248-11E8-B48F-1D18A9856A87","first_name":"Davide","full_name":"Scarselli, Davide","orcid":"0000-0001-5227-4271"}],"has_accepted_license":"1","citation":{"short":"D. Scarselli, New Approaches to Reduce Friction in Turbulent Pipe Flow, Institute of Science and Technology Austria, 2020.","ama":"Scarselli D. New approaches to reduce friction in turbulent pipe flow. 2020. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:7258\">10.15479/AT:ISTA:7258</a>","chicago":"Scarselli, Davide. “New Approaches to Reduce Friction in Turbulent Pipe Flow.” Institute of Science and Technology Austria, 2020. <a href=\"https://doi.org/10.15479/AT:ISTA:7258\">https://doi.org/10.15479/AT:ISTA:7258</a>.","ieee":"D. Scarselli, “New approaches to reduce friction in turbulent pipe flow,” Institute of Science and Technology Austria, 2020.","ista":"Scarselli D. 2020. New approaches to reduce friction in turbulent pipe flow. Institute of Science and Technology Austria.","mla":"Scarselli, Davide. <i>New Approaches to Reduce Friction in Turbulent Pipe Flow</i>. Institute of Science and Technology Austria, 2020, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:7258\">10.15479/AT:ISTA:7258</a>.","apa":"Scarselli, D. (2020). <i>New approaches to reduce friction in turbulent pipe flow</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:7258\">https://doi.org/10.15479/AT:ISTA:7258</a>"},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","file":[{"file_id":"7259","date_created":"2020-01-12T15:57:14Z","access_level":"closed","date_updated":"2021-01-13T23:30:05Z","content_type":"application/zip","file_size":26640830,"embargo_to":"open_access","file_name":"2020_Scarselli_Thesis.zip","creator":"dscarsel","checksum":"4df1ab24e9896635106adde5a54615bf","relation":"source_file"},{"embargo":"2021-01-12","creator":"dscarsel","relation":"main_file","checksum":"48659ab98e3414293c7a721385c2fd1c","date_created":"2020-01-12T15:56:14Z","file_id":"7260","access_level":"open_access","file_size":8515844,"date_updated":"2021-01-13T23:30:05Z","content_type":"application/pdf","file_name":"2020_Scarselli_Thesis.pdf"}],"department":[{"_id":"BjHo"}],"date_updated":"2023-09-15T12:20:08Z","oa_version":"None","_id":"7258","file_date_updated":"2021-01-13T23:30:05Z","date_created":"2020-01-12T16:07:26Z","ddc":["532"],"article_processing_charge":"No","year":"2020","title":"New approaches to reduce friction in turbulent pipe flow","date_published":"2020-01-13T00:00:00Z","project":[{"_id":"25152F3A-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","grant_number":"306589","name":"Decoding the complexity of turbulence at its origin"},{"call_identifier":"H2020","_id":"25104D44-B435-11E9-9278-68D0E5697425","name":"Eliminating turbulence in oil pipelines","grant_number":"737549"},{"_id":"25136C54-B435-11E9-9278-68D0E5697425","grant_number":"HO 4393/1-2","name":"Experimental studies of the turbulence transition and transport processes in turbulent Taylor-Couette currents"}],"related_material":{"record":[{"status":"public","id":"6228","relation":"part_of_dissertation"},{"status":"public","id":"6486","relation":"part_of_dissertation"},{"id":"461","relation":"part_of_dissertation","status":"public"},{"relation":"part_of_dissertation","id":"422","status":"public"}]},"month":"01","alternative_title":["ISTA Thesis"],"ec_funded":1,"day":"13","publication_status":"published","publication_identifier":{"issn":["2663-337X"]},"degree_awarded":"PhD","status":"public","abstract":[{"lang":"eng","text":"Many flows encountered in nature and applications are characterized by a chaotic motion known as turbulence. Turbulent flows generate intense friction with pipe walls and are responsible for considerable amounts of energy losses at world scale. The nature of turbulent friction and techniques aimed at reducing it have been subject of extensive research over the last century, but no definite answer has been found yet. In this thesis we show that in pipes at moderate turbulent Reynolds numbers friction is better described by the power law first introduced by Blasius and not by the Prandtl–von Kármán formula. At higher Reynolds numbers, large scale motions gradually become more important in the flow and can be related to the change in scaling of friction. Next, we present a series of new techniques that can relaminarize turbulence by suppressing a key mechanism that regenerates it at walls, the lift–up effect. In addition, we investigate the process of turbulence decay in several experiments and discuss the drag reduction potential. Finally, we examine the behavior of friction under pulsating conditions inspired by the human heart cycle and we show that under such circumstances turbulent friction can be reduced to produce energy savings."}],"doi":"10.15479/AT:ISTA:7258","page":"174","language":[{"iso":"eng"}],"publisher":"Institute of Science and Technology Austria","supervisor":[{"last_name":"Hof","first_name":"Björn","id":"3A374330-F248-11E8-B48F-1D18A9856A87","full_name":"Hof, Björn","orcid":"0000-0003-2057-2754"}]},{"publisher":"Springer Nature","article_number":"237","intvolume":"        11","article_type":"original","language":[{"iso":"eng"}],"status":"public","publication_identifier":{"issn":["2041-1723"]},"abstract":[{"text":"Advances in shape-morphing materials, such as hydrogels, shape-memory polymers and light-responsive polymers have enabled prescribing self-directed deformations of initially flat geometries. However, most proposed solutions evolve towards a target geometry without considering time-dependent actuation paths. To achieve more complex geometries and avoid self-collisions, it is critical to encode a spatial and temporal shape evolution within the initially flat shell. Recent realizations of time-dependent morphing are limited to the actuation of few, discrete hinges and cannot form doubly curved surfaces. Here, we demonstrate a method for encoding temporal shape evolution in architected shells that assume complex shapes and doubly curved geometries. The shells are non-periodic tessellations of pre-stressed contractile unit cells that soften in water at rates prescribed locally by mesostructure geometry. The ensuing midplane contraction is coupled to the formation of encoded curvatures. We propose an inverse design tool based on a data-driven model for unit cells’ temporal responses.","lang":"eng"}],"doi":"10.1038/s41467-019-14015-2","isi":1,"related_material":{"link":[{"description":"News on IST Homepage","relation":"press_release","url":"https://ist.ac.at/en/news/geometry-meets-time/"}],"record":[{"relation":"dissertation_contains","id":"8366","status":"public"},{"id":"7154","relation":"research_data","status":"public"}]},"month":"01","publication_status":"published","day":"13","ec_funded":1,"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"project":[{"name":"ISTplus - Postdoctoral Fellowships","grant_number":"754411","call_identifier":"H2020","_id":"260C2330-B435-11E9-9278-68D0E5697425"},{"name":"MATERIALIZABLE: Intelligent fabrication-oriented Computational Design and Modeling","grant_number":"715767","call_identifier":"H2020","_id":"24F9549A-B435-11E9-9278-68D0E5697425"}],"title":"Programming temporal morphing of self-actuated shells","date_published":"2020-01-13T00:00:00Z","keyword":["Design","Synthesis and processing","Mechanical engineering","Polymers"],"quality_controlled":"1","ddc":["000"],"date_created":"2020-01-13T16:54:26Z","year":"2020","publication":"Nature Communications","article_processing_charge":"No","volume":11,"_id":"7262","external_id":{"isi":["000511916800015"]},"file_date_updated":"2020-07-14T12:47:55Z","scopus_import":"1","type":"journal_article","oa_version":"Published Version","date_updated":"2024-02-21T12:45:02Z","file":[{"relation":"main_file","checksum":"7db23fef2f4cda712f17f1004116ddff","creator":"rguseino","file_name":"2020_NatureComm_Guseinov.pdf","file_size":1315270,"date_updated":"2020-07-14T12:47:55Z","content_type":"application/pdf","access_level":"open_access","date_created":"2020-01-15T14:35:34Z","file_id":"7336"}],"department":[{"_id":"BeBi"}],"citation":{"ista":"Guseinov R, McMahan C, Perez Rodriguez J, Daraio C, Bickel B. 2020. Programming temporal morphing of self-actuated shells. Nature Communications. 11, 237.","apa":"Guseinov, R., McMahan, C., Perez Rodriguez, J., Daraio, C., &#38; Bickel, B. (2020). Programming temporal morphing of self-actuated shells. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-019-14015-2\">https://doi.org/10.1038/s41467-019-14015-2</a>","mla":"Guseinov, Ruslan, et al. “Programming Temporal Morphing of Self-Actuated Shells.” <i>Nature Communications</i>, vol. 11, 237, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1038/s41467-019-14015-2\">10.1038/s41467-019-14015-2</a>.","ieee":"R. Guseinov, C. McMahan, J. Perez Rodriguez, C. Daraio, and B. Bickel, “Programming temporal morphing of self-actuated shells,” <i>Nature Communications</i>, vol. 11. Springer Nature, 2020.","short":"R. Guseinov, C. McMahan, J. Perez Rodriguez, C. Daraio, B. Bickel, Nature Communications 11 (2020).","ama":"Guseinov R, McMahan C, Perez Rodriguez J, Daraio C, Bickel B. Programming temporal morphing of self-actuated shells. <i>Nature Communications</i>. 2020;11. doi:<a href=\"https://doi.org/10.1038/s41467-019-14015-2\">10.1038/s41467-019-14015-2</a>","chicago":"Guseinov, Ruslan, Connor McMahan, Jesus Perez Rodriguez, Chiara Daraio, and Bernd Bickel. “Programming Temporal Morphing of Self-Actuated Shells.” <i>Nature Communications</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41467-019-14015-2\">https://doi.org/10.1038/s41467-019-14015-2</a>."},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","has_accepted_license":"1","author":[{"orcid":"0000-0001-9819-5077","full_name":"Guseinov, Ruslan","first_name":"Ruslan","id":"3AB45EE2-F248-11E8-B48F-1D18A9856A87","last_name":"Guseinov"},{"first_name":"Connor","full_name":"McMahan, Connor","last_name":"McMahan"},{"full_name":"Perez Rodriguez, Jesus","id":"2DC83906-F248-11E8-B48F-1D18A9856A87","first_name":"Jesus","last_name":"Perez Rodriguez"},{"first_name":"Chiara","full_name":"Daraio, Chiara","last_name":"Daraio"},{"first_name":"Bernd","full_name":"Bickel, Bernd","id":"49876194-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6511-9385","last_name":"Bickel"}],"oa":1},{"month":"01","type":"conference","department":[{"_id":"DaAl"}],"oa_version":"Published Version","publication_status":"published","date_updated":"2021-01-11T15:25:48Z","oa":1,"author":[{"full_name":"Arbel-Raviv, Maya","first_name":"Maya","last_name":"Arbel-Raviv"},{"id":"3569F0A0-F248-11E8-B48F-1D18A9856A87","first_name":"Trevor A","full_name":"Brown, Trevor A","last_name":"Brown"},{"first_name":"Adam","full_name":"Morrison, Adam","last_name":"Morrison"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"ista":"Arbel-Raviv M, Brown TA, Morrison A. 2020. Getting to the root of concurrent binary search tree performance. Proceedings of the 2018 USENIX Annual Technical Conference. USENIX: Annual Technical Conference, 295–306.","mla":"Arbel-Raviv, Maya, et al. “Getting to the Root of Concurrent Binary Search Tree Performance.” <i>Proceedings of the 2018 USENIX Annual Technical Conference</i>, USENIX Association, 2020, pp. 295–306.","apa":"Arbel-Raviv, M., Brown, T. A., &#38; Morrison, A. (2020). Getting to the root of concurrent binary search tree performance. In <i>Proceedings of the 2018 USENIX Annual Technical Conference</i> (pp. 295–306). Boston, MA, United States: USENIX Association.","ieee":"M. Arbel-Raviv, T. A. Brown, and A. Morrison, “Getting to the root of concurrent binary search tree performance,” in <i>Proceedings of the 2018 USENIX Annual Technical Conference</i>, Boston, MA, United States, 2020, pp. 295–306.","short":"M. Arbel-Raviv, T.A. Brown, A. Morrison, in:, Proceedings of the 2018 USENIX Annual Technical Conference, USENIX Association, 2020, pp. 295–306.","ama":"Arbel-Raviv M, Brown TA, Morrison A. Getting to the root of concurrent binary search tree performance. In: <i>Proceedings of the 2018 USENIX Annual Technical Conference</i>. USENIX Association; 2020:295-306.","chicago":"Arbel-Raviv, Maya, Trevor A Brown, and Adam Morrison. “Getting to the Root of Concurrent Binary Search Tree Performance.” In <i>Proceedings of the 2018 USENIX Annual Technical Conference</i>, 295–306. USENIX Association, 2020."},"day":"01","_id":"7272","status":"public","publication_identifier":{"isbn":["9781939133021"]},"scopus_import":"1","abstract":[{"lang":"eng","text":"Many systems rely on optimistic concurrent search trees for multi-core scalability. In principle, optimistic trees have a simple performance story: searches are read-only and so run in parallel, with writes to shared memory occurring only when modifying the data structure. However, this paper shows that in practice, obtaining the full performance benefits of optimistic search trees is not so simple.\r\n\r\nWe focus on optimistic binary search trees (BSTs) and perform a detailed performance analysis of 10 state-of-the-art BSTs on large scale x86-64 hardware, using both microbenchmarks and an in-memory database system. We find and explain significant unexpected performance differences between BSTs with similar tree structure and search implementations, which we trace to subtle performance-degrading interactions of BSTs with systems software and hardware subsystems. We further derive a prescriptive approach to avoid this performance degradation, as well as algorithmic insights on optimistic BST design. Our work underlines the gap between the theory and practice of multi-core performance, and calls for further research to help bridge this gap."}],"date_created":"2020-01-14T07:27:08Z","ddc":["000"],"page":"295-306","year":"2020","main_file_link":[{"url":"https://www.usenix.org/system/files/conference/atc18/atc18-arbel-raviv.pdf","open_access":"1"}],"language":[{"iso":"eng"}],"article_processing_charge":"No","publication":"Proceedings of the 2018 USENIX Annual Technical Conference","conference":{"end_date":"2018-07-13","start_date":"2018-07-11","location":"Boston, MA, United States","name":"USENIX: Annual Technical Conference"},"publisher":"USENIX Association","date_published":"2020-01-01T00:00:00Z","title":"Getting to the root of concurrent binary search tree performance","project":[{"name":"NSERC Postdoctoral fellowship","_id":"26450934-B435-11E9-9278-68D0E5697425"}],"quality_controlled":"1"},{"date_updated":"2023-08-17T14:25:23Z","oa_version":"Published Version","department":[{"_id":"RySh"}],"file":[{"relation":"main_file","checksum":"92f5e8a47f454fc131fb94cd7f106e60","creator":"dernst","access_level":"open_access","date_created":"2020-01-20T14:44:10Z","file_id":"7345","file_name":"2020_JourNeuroscience_Piriya.pdf","file_size":4460781,"content_type":"application/pdf","date_updated":"2020-07-14T12:47:56Z"}],"citation":{"short":"L. Piriya Ananda Babu, H.Y. Wang, K. Eguchi, L. Guillaud, T. Takahashi, Journal of Neuroscience 40 (2020) 131–142.","ama":"Piriya Ananda Babu L, Wang HY, Eguchi K, Guillaud L, Takahashi T. Microtubule and actin differentially regulate synaptic vesicle cycling to maintain high-frequency neurotransmission. <i>Journal of neuroscience</i>. 2020;40(1):131-142. doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.1571-19.2019\">10.1523/JNEUROSCI.1571-19.2019</a>","chicago":"Piriya Ananda Babu, Lashmi, Han Ying Wang, Kohgaku Eguchi, Laurent Guillaud, and Tomoyuki Takahashi. “Microtubule and Actin Differentially Regulate Synaptic Vesicle Cycling to Maintain High-Frequency Neurotransmission.” <i>Journal of Neuroscience</i>. Society for Neuroscience, 2020. <a href=\"https://doi.org/10.1523/JNEUROSCI.1571-19.2019\">https://doi.org/10.1523/JNEUROSCI.1571-19.2019</a>.","ieee":"L. Piriya Ananda Babu, H. Y. Wang, K. Eguchi, L. Guillaud, and T. Takahashi, “Microtubule and actin differentially regulate synaptic vesicle cycling to maintain high-frequency neurotransmission,” <i>Journal of neuroscience</i>, vol. 40, no. 1. Society for Neuroscience, pp. 131–142, 2020.","ista":"Piriya Ananda Babu L, Wang HY, Eguchi K, Guillaud L, Takahashi T. 2020. Microtubule and actin differentially regulate synaptic vesicle cycling to maintain high-frequency neurotransmission. Journal of neuroscience. 40(1), 131–142.","apa":"Piriya Ananda Babu, L., Wang, H. Y., Eguchi, K., Guillaud, L., &#38; Takahashi, T. (2020). Microtubule and actin differentially regulate synaptic vesicle cycling to maintain high-frequency neurotransmission. <i>Journal of Neuroscience</i>. Society for Neuroscience. <a href=\"https://doi.org/10.1523/JNEUROSCI.1571-19.2019\">https://doi.org/10.1523/JNEUROSCI.1571-19.2019</a>","mla":"Piriya Ananda Babu, Lashmi, et al. “Microtubule and Actin Differentially Regulate Synaptic Vesicle Cycling to Maintain High-Frequency Neurotransmission.” <i>Journal of Neuroscience</i>, vol. 40, no. 1, Society for Neuroscience, 2020, pp. 131–42, doi:<a href=\"https://doi.org/10.1523/JNEUROSCI.1571-19.2019\">10.1523/JNEUROSCI.1571-19.2019</a>."},"has_accepted_license":"1","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","author":[{"last_name":"Piriya Ananda Babu","first_name":"Lashmi","full_name":"Piriya Ananda Babu, Lashmi"},{"first_name":"Han Ying","full_name":"Wang, Han Ying","last_name":"Wang"},{"last_name":"Eguchi","first_name":"Kohgaku","id":"2B7846DC-F248-11E8-B48F-1D18A9856A87","full_name":"Eguchi, Kohgaku","orcid":"0000-0002-6170-2546"},{"last_name":"Guillaud","first_name":"Laurent","full_name":"Guillaud, Laurent"},{"last_name":"Takahashi","first_name":"Tomoyuki","full_name":"Takahashi, Tomoyuki"}],"oa":1,"type":"journal_article","external_id":{"isi":["000505167600013"],"pmid":["31767677"]},"file_date_updated":"2020-07-14T12:47:56Z","scopus_import":"1","_id":"7339","year":"2020","publication":"Journal of neuroscience","volume":40,"article_processing_charge":"No","ddc":["570"],"date_created":"2020-01-19T23:00:38Z","date_published":"2020-01-02T00:00:00Z","title":"Microtubule and actin differentially regulate synaptic vesicle cycling to maintain high-frequency neurotransmission","quality_controlled":"1","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publication_status":"published","day":"02","isi":1,"month":"01","issue":"1","abstract":[{"text":"Cytoskeletal filaments such as microtubules (MTs) and filamentous actin (F-actin) dynamically support cell structure and functions. In central presynaptic terminals, F-actin is expressed along the release edge and reportedly plays diverse functional roles, but whether axonal MTs extend deep into terminals and play any physiological role remains controversial. At the calyx of Held in rats of either sex, confocal and high-resolution microscopy revealed that MTs enter deep into presynaptic terminal swellings and partially colocalize with a subset of synaptic vesicles (SVs). Electrophysiological analysis demonstrated that depolymerization of MTs specifically prolonged the slow-recovery time component of EPSCs from short-term depression induced by a train of high-frequency stimulation, whereas depolymerization of F-actin specifically prolonged the fast-recovery component. In simultaneous presynaptic and postsynaptic action potential recordings, depolymerization of MTs or F-actin significantly impaired the fidelity of high-frequency neurotransmission. We conclude that MTs and F-actin differentially contribute to slow and fast SV replenishment, thereby maintaining high-frequency neurotransmission.","lang":"eng"}],"doi":"10.1523/JNEUROSCI.1571-19.2019","status":"public","pmid":1,"publication_identifier":{"eissn":["15292401"]},"language":[{"iso":"eng"}],"intvolume":"        40","page":"131-142","article_type":"original","publisher":"Society for Neuroscience"},{"tmp":{"image":"/images/cc_by_nc.png","short":"CC BY-NC (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)"},"date_published":"2020-03-01T00:00:00Z","title":"Social immunity modulates competition between coinfecting pathogens","project":[{"name":"International IST Postdoc Fellowship Programme","grant_number":"291734","call_identifier":"FP7","_id":"25681D80-B435-11E9-9278-68D0E5697425"},{"grant_number":"CR-118/3-1","name":"Host-Parasite Coevolution","_id":"25DAF0B2-B435-11E9-9278-68D0E5697425"}],"quality_controlled":"1","date_created":"2020-01-20T13:32:12Z","ddc":["570"],"year":"2020","article_processing_charge":"Yes (via OA deal)","volume":23,"publication":"Ecology Letters","_id":"7343","external_id":{"isi":["000507515900001"]},"scopus_import":"1","file_date_updated":"2020-11-19T11:27:10Z","type":"journal_article","department":[{"_id":"SyCr"},{"_id":"KrCh"}],"file":[{"file_size":561749,"content_type":"application/pdf","date_updated":"2020-11-19T11:27:10Z","file_name":"2020_EcologyLetters_Milutinovic.pdf","date_created":"2020-11-19T11:27:10Z","success":1,"file_id":"8776","access_level":"open_access","creator":"dernst","relation":"main_file","checksum":"0cd8be386fa219db02845b7c3991ce04"}],"date_updated":"2023-09-05T16:04:49Z","oa_version":"Published Version","oa":1,"author":[{"last_name":"Milutinovic","orcid":"0000-0002-8214-4758","id":"2CDC32B8-F248-11E8-B48F-1D18A9856A87","first_name":"Barbara","full_name":"Milutinovic, Barbara"},{"full_name":"Stock, Miriam","id":"42462816-F248-11E8-B48F-1D18A9856A87","first_name":"Miriam","last_name":"Stock"},{"first_name":"Anna V","full_name":"Grasse, Anna V","id":"406F989C-F248-11E8-B48F-1D18A9856A87","last_name":"Grasse"},{"first_name":"Elisabeth","full_name":"Naderlinger, Elisabeth","id":"31757262-F248-11E8-B48F-1D18A9856A87","last_name":"Naderlinger"},{"orcid":"0000-0001-5116-955X","full_name":"Hilbe, Christian","id":"2FDF8F3C-F248-11E8-B48F-1D18A9856A87","first_name":"Christian","last_name":"Hilbe"},{"orcid":"0000-0002-2193-3868","full_name":"Cremer, Sylvia","first_name":"Sylvia","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","last_name":"Cremer"}],"citation":{"apa":"Milutinovic, B., Stock, M., Grasse, A. V., Naderlinger, E., Hilbe, C., &#38; Cremer, S. (2020). Social immunity modulates competition between coinfecting pathogens. <i>Ecology Letters</i>. Wiley. <a href=\"https://doi.org/10.1111/ele.13458\">https://doi.org/10.1111/ele.13458</a>","mla":"Milutinovic, Barbara, et al. “Social Immunity Modulates Competition between Coinfecting Pathogens.” <i>Ecology Letters</i>, vol. 23, no. 3, Wiley, 2020, pp. 565–74, doi:<a href=\"https://doi.org/10.1111/ele.13458\">10.1111/ele.13458</a>.","ista":"Milutinovic B, Stock M, Grasse AV, Naderlinger E, Hilbe C, Cremer S. 2020. Social immunity modulates competition between coinfecting pathogens. Ecology Letters. 23(3), 565–574.","chicago":"Milutinovic, Barbara, Miriam Stock, Anna V Grasse, Elisabeth Naderlinger, Christian Hilbe, and Sylvia Cremer. “Social Immunity Modulates Competition between Coinfecting Pathogens.” <i>Ecology Letters</i>. Wiley, 2020. <a href=\"https://doi.org/10.1111/ele.13458\">https://doi.org/10.1111/ele.13458</a>.","ama":"Milutinovic B, Stock M, Grasse AV, Naderlinger E, Hilbe C, Cremer S. Social immunity modulates competition between coinfecting pathogens. <i>Ecology Letters</i>. 2020;23(3):565-574. doi:<a href=\"https://doi.org/10.1111/ele.13458\">10.1111/ele.13458</a>","short":"B. Milutinovic, M. Stock, A.V. Grasse, E. Naderlinger, C. Hilbe, S. Cremer, Ecology Letters 23 (2020) 565–574.","ieee":"B. Milutinovic, M. Stock, A. V. Grasse, E. Naderlinger, C. Hilbe, and S. Cremer, “Social immunity modulates competition between coinfecting pathogens,” <i>Ecology Letters</i>, vol. 23, no. 3. Wiley, pp. 565–574, 2020."},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","has_accepted_license":"1","publisher":"Wiley","intvolume":"        23","page":"565-574","article_type":"letter_note","language":[{"iso":"eng"}],"status":"public","publication_identifier":{"eissn":["1461-0248"],"issn":["1461-023X"]},"acknowledged_ssus":[{"_id":"LifeSc"}],"issue":"3","abstract":[{"text":"Coinfections with multiple pathogens can result in complex within‐host dynamics affecting virulence and transmission. While multiple infections are intensively studied in solitary hosts, it is so far unresolved how social host interactions interfere with pathogen competition, and if this depends on coinfection diversity. We studied how the collective disease defences of ants – their social immunity – influence pathogen competition in coinfections of same or different fungal pathogen species. Social immunity reduced virulence for all pathogen combinations, but interfered with spore production only in different‐species coinfections. Here, it decreased overall pathogen sporulation success while increasing co‐sporulation on individual cadavers and maintaining a higher pathogen diversity at the community level. Mathematical modelling revealed that host sanitary care alone can modulate competitive outcomes between pathogens, giving advantage to fast‐germinating, thus less grooming‐sensitive ones. Host social interactions can hence modulate infection dynamics in coinfected group members, thereby altering pathogen communities at the host level and population level.","lang":"eng"}],"doi":"10.1111/ele.13458","related_material":{"record":[{"status":"public","id":"13060","relation":"research_data"}],"link":[{"description":"News on IST Homepage","url":"https://ist.ac.at/en/news/social-ants-shapes-disease-outcome/","relation":"press_release"}]},"month":"03","isi":1,"acknowledgement":"We thank Bernhardt Steinwender and Jorgen Eilenberg for the fungal strains, Xavier Espadaler, Mireia Diaz, Christiane Wanke, Lumi Viljakainen and the Social Immunity Team at IST Austria, for help with ant collection, and Wanda Gorecka and Gertraud Stift of the IST Austria Life Science Facility for technical support. We are thankful to Dieter Ebert for input at all stages of the project, Roger Mundry for statistical advice, Hinrich Schulenburg, Paul Schmid-Hempel, Yuko\r\nUlrich and Joachim Kurtz for project discussion, Bor Kavcic for advice on growth curves, Marcus Roper for advice on modelling work and comments on the manuscript, as well as Marjon de Vos, Weini Huang and the Social Immunity Team for comments on the manuscript.\r\nThis study was funded by the German Research Foundation (DFG) within the Priority Programme 1399 Host-parasite Coevolution (CR 118/3 to S.C.) and the People Programme\r\n(Marie Curie Actions) of the European Union’s Seventh Framework Programme (FP7/2007-2013) under REA grant agreement no 291734 (ISTFELLOW to B.M.). ","publication_status":"published","ec_funded":1,"day":"01"},{"article_number":"21","intvolume":"       153","arxiv":1,"language":[{"iso":"eng"}],"publisher":"Schloss Dagstuhl - Leibniz-Zentrum für Informatik","alternative_title":["LIPIcs"],"month":"02","publication_status":"published","day":"10","status":"public","abstract":[{"lang":"eng","text":"The Price of Anarchy (PoA) is a well-established game-theoretic concept to shed light on coordination issues arising in open distributed systems. Leaving agents to selfishly optimize comes with the risk of ending up in sub-optimal states (in terms of performance and/or costs), compared to a centralized system design. However, the PoA relies on strong assumptions about agents' rationality (e.g., resources and information) and interactions, whereas in many distributed systems agents interact locally with bounded resources. They do so repeatedly over time (in contrast to \"one-shot games\"), and their strategies may evolve. Using a more realistic evolutionary game model, this paper introduces a realized evolutionary Price of Anarchy (ePoA). The ePoA allows an exploration of equilibrium selection in dynamic distributed systems with multiple equilibria, based on local interactions of simple memoryless agents. Considering a fundamental game related to virus propagation on networks, we present analytical bounds on the ePoA in basic network topologies and for different strategy update dynamics. In particular, deriving stationary distributions of the stochastic evolutionary process, we find that the Nash equilibria are not always the most abundant states, and that different processes can feature significant off-equilibrium behavior, leading to a significantly higher ePoA compared to the PoA studied traditionally in the literature. "}],"doi":"10.4230/LIPIcs.OPODIS.2019.21","ddc":["000"],"date_created":"2020-01-21T16:00:26Z","year":"2020","publication":"Proceedings of the 23rd International Conference on Principles of Distributed Systems","article_processing_charge":"No","volume":153,"conference":{"name":"OPODIS: International Conference on Principles of Distributed Systems","location":"Neuchâtel, Switzerland","start_date":"2019-12-17","end_date":"2019-12-19"},"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"project":[{"name":"Rigorous Systems Engineering","grant_number":"S 11407_N23","call_identifier":"FWF","_id":"25832EC2-B435-11E9-9278-68D0E5697425"}],"title":"The evolutionary price of anarchy: Locally bounded agents in a dynamic virus game","date_published":"2020-02-10T00:00:00Z","quality_controlled":"1","type":"conference","date_updated":"2023-02-23T13:05:49Z","oa_version":"Preprint","department":[{"_id":"KrCh"}],"file":[{"creator":"dernst","checksum":"9a91916ac2c21ab42458fcda39ef0b8d","relation":"main_file","file_id":"7608","date_created":"2020-03-23T09:14:06Z","access_level":"open_access","content_type":"application/pdf","date_updated":"2020-07-14T12:47:56Z","file_size":630752,"file_name":"2019_LIPIcS_Schmid.pdf"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"ista":"Schmid L, Chatterjee K, Schmid S. 2020. The evolutionary price of anarchy: Locally bounded agents in a dynamic virus game. Proceedings of the 23rd International Conference on Principles of Distributed Systems. OPODIS: International Conference on Principles of Distributed Systems, LIPIcs, vol. 153, 21.","mla":"Schmid, Laura, et al. “The Evolutionary Price of Anarchy: Locally Bounded Agents in a Dynamic Virus Game.” <i>Proceedings of the 23rd International Conference on Principles of Distributed Systems</i>, vol. 153, 21, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2020, doi:<a href=\"https://doi.org/10.4230/LIPIcs.OPODIS.2019.21\">10.4230/LIPIcs.OPODIS.2019.21</a>.","apa":"Schmid, L., Chatterjee, K., &#38; Schmid, S. (2020). The evolutionary price of anarchy: Locally bounded agents in a dynamic virus game. In <i>Proceedings of the 23rd International Conference on Principles of Distributed Systems</i> (Vol. 153). Neuchâtel, Switzerland: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. <a href=\"https://doi.org/10.4230/LIPIcs.OPODIS.2019.21\">https://doi.org/10.4230/LIPIcs.OPODIS.2019.21</a>","ama":"Schmid L, Chatterjee K, Schmid S. The evolutionary price of anarchy: Locally bounded agents in a dynamic virus game. In: <i>Proceedings of the 23rd International Conference on Principles of Distributed Systems</i>. Vol 153. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2020. doi:<a href=\"https://doi.org/10.4230/LIPIcs.OPODIS.2019.21\">10.4230/LIPIcs.OPODIS.2019.21</a>","short":"L. Schmid, K. Chatterjee, S. Schmid, in:, Proceedings of the 23rd International Conference on Principles of Distributed Systems, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2020.","chicago":"Schmid, Laura, Krishnendu Chatterjee, and Stefan Schmid. “The Evolutionary Price of Anarchy: Locally Bounded Agents in a Dynamic Virus Game.” In <i>Proceedings of the 23rd International Conference on Principles of Distributed Systems</i>, Vol. 153. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2020. <a href=\"https://doi.org/10.4230/LIPIcs.OPODIS.2019.21\">https://doi.org/10.4230/LIPIcs.OPODIS.2019.21</a>.","ieee":"L. Schmid, K. Chatterjee, and S. Schmid, “The evolutionary price of anarchy: Locally bounded agents in a dynamic virus game,” in <i>Proceedings of the 23rd International Conference on Principles of Distributed Systems</i>, Neuchâtel, Switzerland, 2020, vol. 153."},"has_accepted_license":"1","oa":1,"author":[{"orcid":"0000-0002-6978-7329","id":"38B437DE-F248-11E8-B48F-1D18A9856A87","first_name":"Laura","full_name":"Schmid, Laura","last_name":"Schmid"},{"last_name":"Chatterjee","first_name":"Krishnendu","full_name":"Chatterjee, Krishnendu","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4561-241X"},{"last_name":"Schmid","first_name":"Stefan","full_name":"Schmid, Stefan"}],"_id":"7346","external_id":{"arxiv":["1906.00110"]},"file_date_updated":"2020-07-14T12:47:56Z","scopus_import":"1"},{"ddc":["000"],"date_created":"2020-01-21T11:22:21Z","year":"2020","publication":"28th EACSL Annual Conference on Computer Science Logic","volume":152,"article_processing_charge":"No","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"conference":{"location":"Barcelona, Spain","start_date":"2020-01-13","end_date":"2020-01-16","name":"CSL: Computer Science Logic"},"project":[{"_id":"25F2ACDE-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","name":"Rigorous Systems Engineering","grant_number":"S11402-N23"},{"_id":"25F42A32-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","name":"The Wittgenstein Prize","grant_number":"Z211"}],"date_published":"2020-01-15T00:00:00Z","title":"Monitoring event frequencies","quality_controlled":"1","type":"conference","oa_version":"Published Version","date_updated":"2021-01-12T08:13:12Z","department":[{"_id":"ToHe"}],"file":[{"creator":"bkragl","relation":"main_file","checksum":"b9a691d658d075c6369d3304d17fb818","date_created":"2020-01-21T11:21:04Z","file_id":"7349","access_level":"open_access","file_size":617206,"date_updated":"2020-07-14T12:47:56Z","content_type":"application/pdf","file_name":"main.pdf"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"apa":"Ferrere, T., Henzinger, T. A., &#38; Kragl, B. (2020). Monitoring event frequencies. In <i>28th EACSL Annual Conference on Computer Science Logic</i> (Vol. 152). Barcelona, Spain: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. <a href=\"https://doi.org/10.4230/LIPIcs.CSL.2020.20\">https://doi.org/10.4230/LIPIcs.CSL.2020.20</a>","mla":"Ferrere, Thomas, et al. “Monitoring Event Frequencies.” <i>28th EACSL Annual Conference on Computer Science Logic</i>, vol. 152, 20, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2020, doi:<a href=\"https://doi.org/10.4230/LIPIcs.CSL.2020.20\">10.4230/LIPIcs.CSL.2020.20</a>.","ista":"Ferrere T, Henzinger TA, Kragl B. 2020. Monitoring event frequencies. 28th EACSL Annual Conference on Computer Science Logic. CSL: Computer Science Logic, LIPIcs, vol. 152, 20.","ieee":"T. Ferrere, T. A. Henzinger, and B. Kragl, “Monitoring event frequencies,” in <i>28th EACSL Annual Conference on Computer Science Logic</i>, Barcelona, Spain, 2020, vol. 152.","chicago":"Ferrere, Thomas, Thomas A Henzinger, and Bernhard Kragl. “Monitoring Event Frequencies.” In <i>28th EACSL Annual Conference on Computer Science Logic</i>, Vol. 152. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2020. <a href=\"https://doi.org/10.4230/LIPIcs.CSL.2020.20\">https://doi.org/10.4230/LIPIcs.CSL.2020.20</a>.","ama":"Ferrere T, Henzinger TA, Kragl B. Monitoring event frequencies. In: <i>28th EACSL Annual Conference on Computer Science Logic</i>. Vol 152. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2020. doi:<a href=\"https://doi.org/10.4230/LIPIcs.CSL.2020.20\">10.4230/LIPIcs.CSL.2020.20</a>","short":"T. Ferrere, T.A. Henzinger, B. Kragl, in:, 28th EACSL Annual Conference on Computer Science Logic, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2020."},"has_accepted_license":"1","author":[{"orcid":"0000-0001-5199-3143","id":"40960E6E-F248-11E8-B48F-1D18A9856A87","full_name":"Ferrere, Thomas","first_name":"Thomas","last_name":"Ferrere"},{"first_name":"Thomas A","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","full_name":"Henzinger, Thomas A","orcid":"0000−0002−2985−7724","last_name":"Henzinger"},{"orcid":"0000-0001-7745-9117","id":"320FC952-F248-11E8-B48F-1D18A9856A87","first_name":"Bernhard","full_name":"Kragl, Bernhard","last_name":"Kragl"}],"oa":1,"_id":"7348","external_id":{"arxiv":["1910.06097"]},"file_date_updated":"2020-07-14T12:47:56Z","scopus_import":1,"article_number":"20","intvolume":"       152","arxiv":1,"language":[{"iso":"eng"}],"publisher":"Schloss Dagstuhl - Leibniz-Zentrum für Informatik","alternative_title":["LIPIcs"],"month":"01","publication_status":"published","day":"15","status":"public","publication_identifier":{"isbn":["9783959771320"],"issn":["1868-8969"]},"abstract":[{"text":"The monitoring of event frequencies can be used to recognize behavioral anomalies, to identify trends, and to deduce or discard hypotheses about the underlying system. For example, the performance of a web server may be monitored based on the ratio of the total count of requests from the least and most active clients. Exact frequency monitoring, however, can be prohibitively expensive; in the above example it would require as many counters as there are clients. In this paper, we propose the efficient probabilistic monitoring of common frequency properties, including the mode (i.e., the most common event) and the median of an event sequence. We define a logic to express composite frequency properties as a combination of atomic frequency properties. Our main contribution is an algorithm that, under suitable probabilistic assumptions, can be used to monitor these important frequency properties with four counters, independent of the number of different events. Our algorithm samples longer and longer subwords of an infinite event sequence. We prove the almost-sure convergence of our algorithm by generalizing ergodic theory from increasing-length prefixes to increasing-length subwords of an infinite sequence. A similar algorithm could be used to learn a connected Markov chain of a given structure from observing its outputs, to arbitrary precision, for a given confidence. ","lang":"eng"}],"doi":"10.4230/LIPIcs.CSL.2020.20"},{"abstract":[{"lang":"eng","text":"The ability to sense environmental temperature and to coordinate growth and development accordingly, is critical to the reproductive success of plants. Flowering time is regulated at the level of gene expression by a complex network of factors that integrate environmental and developmental cues. One of the main players, involved in modulating flowering time in response to changes in ambient temperature is FLOWERING LOCUS M (FLM). FLM transcripts can undergo extensive alternative splicing producing multiple variants, of which FLM-β and FLM-δ are the most representative. While FLM-β codes for the flowering repressor FLM protein, translation of FLM-δ has the opposite effect on flowering. Here we show that the cyclin-dependent kinase G2 (CDKG2), together with its cognate cyclin, CYCLYN L1 (CYCL1) affects the alternative splicing of FLM, balancing the levels of FLM-β and FLM-δ across the ambient temperature range. In the absence of the CDKG2/CYCL1 complex, FLM-β expression is reduced while FLM-δ is increased in a temperature dependent manner and these changes are associated with an early flowering phenotype in the cdkg2 mutant lines. In addition, we found that transcript variants retaining the full FLM intron 1 are sequestered in the cell nucleus. Strikingly, FLM intron 1 splicing is also regulated by CDKG2/CYCL1. Our results provide evidence that temperature and CDKs regulate the alternative splicing of FLM, contributing to flowering time definition."}],"doi":"10.3389/fpls.2019.01680","publication_identifier":{"issn":["1664-462X"]},"status":"public","day":"22","publication_status":"published","month":"01","isi":1,"publisher":"Frontiers Media","language":[{"iso":"eng"}],"article_type":"original","intvolume":"        10","article_number":"1680","scopus_import":"1","file_date_updated":"2020-07-14T12:47:56Z","external_id":{"isi":["000511376000001"]},"_id":"7350","oa":1,"author":[{"first_name":"Candida","full_name":"Nibau, Candida","last_name":"Nibau"},{"last_name":"Gallemi","full_name":"Gallemi, Marçal","first_name":"Marçal","id":"460C6802-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-4675-6893"},{"full_name":"Dadarou, Despoina","first_name":"Despoina","last_name":"Dadarou"},{"first_name":"John H.","full_name":"Doonan, John H.","last_name":"Doonan"},{"last_name":"Cavallari","full_name":"Cavallari, Nicola","first_name":"Nicola","id":"457160E6-F248-11E8-B48F-1D18A9856A87"}],"has_accepted_license":"1","citation":{"short":"C. Nibau, M. Gallemi, D. Dadarou, J.H. Doonan, N. Cavallari, Frontiers in Plant Science 10 (2020).","ama":"Nibau C, Gallemi M, Dadarou D, Doonan JH, Cavallari N. Thermo-sensitive alternative splicing of FLOWERING LOCUS M is modulated by cyclin-dependent kinase G2. <i>Frontiers in Plant Science</i>. 2020;10. doi:<a href=\"https://doi.org/10.3389/fpls.2019.01680\">10.3389/fpls.2019.01680</a>","chicago":"Nibau, Candida, Marçal Gallemi, Despoina Dadarou, John H. Doonan, and Nicola Cavallari. “Thermo-Sensitive Alternative Splicing of FLOWERING LOCUS M Is Modulated by Cyclin-Dependent Kinase G2.” <i>Frontiers in Plant Science</i>. Frontiers Media, 2020. <a href=\"https://doi.org/10.3389/fpls.2019.01680\">https://doi.org/10.3389/fpls.2019.01680</a>.","ieee":"C. Nibau, M. Gallemi, D. Dadarou, J. H. Doonan, and N. Cavallari, “Thermo-sensitive alternative splicing of FLOWERING LOCUS M is modulated by cyclin-dependent kinase G2,” <i>Frontiers in Plant Science</i>, vol. 10. Frontiers Media, 2020.","ista":"Nibau C, Gallemi M, Dadarou D, Doonan JH, Cavallari N. 2020. Thermo-sensitive alternative splicing of FLOWERING LOCUS M is modulated by cyclin-dependent kinase G2. Frontiers in Plant Science. 10, 1680.","apa":"Nibau, C., Gallemi, M., Dadarou, D., Doonan, J. H., &#38; Cavallari, N. (2020). Thermo-sensitive alternative splicing of FLOWERING LOCUS M is modulated by cyclin-dependent kinase G2. <i>Frontiers in Plant Science</i>. Frontiers Media. <a href=\"https://doi.org/10.3389/fpls.2019.01680\">https://doi.org/10.3389/fpls.2019.01680</a>","mla":"Nibau, Candida, et al. “Thermo-Sensitive Alternative Splicing of FLOWERING LOCUS M Is Modulated by Cyclin-Dependent Kinase G2.” <i>Frontiers in Plant Science</i>, vol. 10, 1680, Frontiers Media, 2020, doi:<a href=\"https://doi.org/10.3389/fpls.2019.01680\">10.3389/fpls.2019.01680</a>."},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","file":[{"file_name":"2020_FrontiersPlantScience_Nibau.pdf","file_size":1951438,"content_type":"application/pdf","date_updated":"2020-07-14T12:47:56Z","access_level":"open_access","date_created":"2020-01-27T09:07:02Z","file_id":"7366","relation":"main_file","checksum":"d1f92e60a713fbd15097ce895e5c7ccb","creator":"dernst"}],"department":[{"_id":"EvBe"}],"oa_version":"Published Version","date_updated":"2023-08-17T14:21:45Z","type":"journal_article","quality_controlled":"1","date_published":"2020-01-22T00:00:00Z","title":"Thermo-sensitive alternative splicing of FLOWERING LOCUS M is modulated by cyclin-dependent kinase G2","tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"article_processing_charge":"No","volume":10,"publication":"Frontiers in Plant Science","year":"2020","date_created":"2020-01-22T15:23:57Z","ddc":["580"]},{"publication_status":"published","day":"17","isi":1,"month":"01","license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","abstract":[{"lang":"eng","text":"We present nsCouette, a highly scalable software tool to solve the Navier–Stokes equations for incompressible fluid flow between differentially heated and independently rotating, concentric cylinders. It is based on a pseudospectral spatial discretization and dynamic time-stepping. It is implemented in modern Fortran with a hybrid MPI-OpenMP parallelization scheme and thus designed to compute turbulent flows at high Reynolds and Rayleigh numbers. An additional GPU implementation (C-CUDA) for intermediate problem sizes and a version for pipe flow (nsPipe) are also provided."}],"doi":"10.1016/j.softx.2019.100395","status":"public","publication_identifier":{"eissn":["23527110"]},"arxiv":1,"language":[{"iso":"eng"}],"article_number":"100395","intvolume":"        11","article_type":"original","publisher":"Elsevier","oa_version":"Published Version","date_updated":"2023-08-17T14:29:59Z","file":[{"access_level":"open_access","file_id":"7365","date_created":"2020-01-27T07:32:46Z","file_name":"2020_SoftwareX_Lopez.pdf","date_updated":"2020-07-14T12:47:56Z","content_type":"application/pdf","file_size":679707,"checksum":"2af1a1a3cc33557b345145276f221668","relation":"main_file","creator":"dernst"}],"department":[{"_id":"BjHo"}],"citation":{"mla":"Lopez Alonso, Jose M., et al. “NsCouette – A High-Performance Code for Direct Numerical Simulations of Turbulent Taylor–Couette Flow.” <i>SoftwareX</i>, vol. 11, 100395, Elsevier, 2020, doi:<a href=\"https://doi.org/10.1016/j.softx.2019.100395\">10.1016/j.softx.2019.100395</a>.","apa":"Lopez Alonso, J. M., Feldmann, D., Rampp, M., Vela-Martín, A., Shi, L., &#38; Avila, M. (2020). nsCouette – A high-performance code for direct numerical simulations of turbulent Taylor–Couette flow. <i>SoftwareX</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.softx.2019.100395\">https://doi.org/10.1016/j.softx.2019.100395</a>","ista":"Lopez Alonso JM, Feldmann D, Rampp M, Vela-Martín A, Shi L, Avila M. 2020. nsCouette – A high-performance code for direct numerical simulations of turbulent Taylor–Couette flow. SoftwareX. 11, 100395.","chicago":"Lopez Alonso, Jose M, Daniel Feldmann, Markus Rampp, Alberto Vela-Martín, Liang Shi, and Marc Avila. “NsCouette – A High-Performance Code for Direct Numerical Simulations of Turbulent Taylor–Couette Flow.” <i>SoftwareX</i>. Elsevier, 2020. <a href=\"https://doi.org/10.1016/j.softx.2019.100395\">https://doi.org/10.1016/j.softx.2019.100395</a>.","ama":"Lopez Alonso JM, Feldmann D, Rampp M, Vela-Martín A, Shi L, Avila M. nsCouette – A high-performance code for direct numerical simulations of turbulent Taylor–Couette flow. <i>SoftwareX</i>. 2020;11. doi:<a href=\"https://doi.org/10.1016/j.softx.2019.100395\">10.1016/j.softx.2019.100395</a>","short":"J.M. Lopez Alonso, D. Feldmann, M. Rampp, A. Vela-Martín, L. Shi, M. Avila, SoftwareX 11 (2020).","ieee":"J. M. Lopez Alonso, D. Feldmann, M. Rampp, A. Vela-Martín, L. Shi, and M. Avila, “nsCouette – A high-performance code for direct numerical simulations of turbulent Taylor–Couette flow,” <i>SoftwareX</i>, vol. 11. Elsevier, 2020."},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","has_accepted_license":"1","oa":1,"author":[{"id":"40770848-F248-11E8-B48F-1D18A9856A87","first_name":"Jose M","full_name":"Lopez Alonso, Jose M","orcid":"0000-0002-0384-2022","last_name":"Lopez Alonso"},{"last_name":"Feldmann","full_name":"Feldmann, Daniel","first_name":"Daniel"},{"first_name":"Markus","full_name":"Rampp, Markus","last_name":"Rampp"},{"full_name":"Vela-Martín, Alberto","first_name":"Alberto","last_name":"Vela-Martín"},{"full_name":"Shi, Liang","first_name":"Liang","id":"374A3F1A-F248-11E8-B48F-1D18A9856A87","last_name":"Shi"},{"last_name":"Avila","first_name":"Marc","full_name":"Avila, Marc"}],"type":"journal_article","external_id":{"isi":["000552271200011"],"arxiv":["1908.00587"]},"file_date_updated":"2020-07-14T12:47:56Z","scopus_import":"1","_id":"7364","year":"2020","publication":"SoftwareX","article_processing_charge":"No","volume":11,"ddc":["000"],"date_created":"2020-01-26T23:00:35Z","title":"nsCouette – A high-performance code for direct numerical simulations of turbulent Taylor–Couette flow","date_published":"2020-01-17T00:00:00Z","quality_controlled":"1","tmp":{"image":"/images/cc_by_nc_nd.png","short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)"}},{"_id":"7369","external_id":{"isi":["000515321800006"]},"file_date_updated":"2020-07-14T12:47:56Z","scopus_import":"1","type":"journal_article","oa_version":"Published Version","date_updated":"2023-08-17T14:35:22Z","department":[{"_id":"SaSi"}],"file":[{"checksum":"036e9451d6cd0c190ad25791bf82393b","relation":"supplementary_material","creator":"rcubero","access_level":"open_access","file_id":"7380","date_created":"2020-01-28T09:31:09Z","file_name":"10827_2020_740_MOESM1_ESM.pdf","content_type":"application/pdf","date_updated":"2020-07-14T12:47:56Z","file_size":1941355},{"creator":"rcubero","checksum":"4dd8b1fd4b54486f79d82ac7b2a412b2","relation":"main_file","date_updated":"2020-07-14T12:47:56Z","content_type":"application/pdf","file_size":3257880,"file_name":"Cubero2020_Article_MultiscaleRelevanceAndInformat.pdf","file_id":"7381","date_created":"2020-01-28T09:31:09Z","access_level":"open_access"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","citation":{"apa":"Cubero, R. J., Marsili, M., &#38; Roudi, Y. (2020). Multiscale relevance and informative encoding in neuronal spike trains. <i>Journal of Computational Neuroscience</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s10827-020-00740-x\">https://doi.org/10.1007/s10827-020-00740-x</a>","mla":"Cubero, Ryan J., et al. “Multiscale Relevance and Informative Encoding in Neuronal Spike Trains.” <i>Journal of Computational Neuroscience</i>, vol. 48, Springer Nature, 2020, pp. 85–102, doi:<a href=\"https://doi.org/10.1007/s10827-020-00740-x\">10.1007/s10827-020-00740-x</a>.","ista":"Cubero RJ, Marsili M, Roudi Y. 2020. Multiscale relevance and informative encoding in neuronal spike trains. Journal of Computational Neuroscience. 48, 85–102.","ieee":"R. J. Cubero, M. Marsili, and Y. Roudi, “Multiscale relevance and informative encoding in neuronal spike trains,” <i>Journal of Computational Neuroscience</i>, vol. 48. Springer Nature, pp. 85–102, 2020.","chicago":"Cubero, Ryan J, Matteo Marsili, and Yasser Roudi. “Multiscale Relevance and Informative Encoding in Neuronal Spike Trains.” <i>Journal of Computational Neuroscience</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1007/s10827-020-00740-x\">https://doi.org/10.1007/s10827-020-00740-x</a>.","ama":"Cubero RJ, Marsili M, Roudi Y. Multiscale relevance and informative encoding in neuronal spike trains. <i>Journal of Computational Neuroscience</i>. 2020;48:85-102. doi:<a href=\"https://doi.org/10.1007/s10827-020-00740-x\">10.1007/s10827-020-00740-x</a>","short":"R.J. Cubero, M. Marsili, Y. Roudi, Journal of Computational Neuroscience 48 (2020) 85–102."},"has_accepted_license":"1","oa":1,"author":[{"last_name":"Cubero","first_name":"Ryan J","id":"850B2E12-9CD4-11E9-837F-E719E6697425","full_name":"Cubero, Ryan J","orcid":"0000-0003-0002-1867"},{"last_name":"Marsili","first_name":"Matteo","full_name":"Marsili, Matteo"},{"last_name":"Roudi","full_name":"Roudi, Yasser","first_name":"Yasser"}],"tmp":{"image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"project":[{"call_identifier":"H2020","_id":"260C2330-B435-11E9-9278-68D0E5697425","grant_number":"754411","name":"ISTplus - Postdoctoral Fellowships"}],"keyword":["Time series analysis","Multiple time scale analysis","Spike train data","Information theory","Bayesian decoding"],"title":"Multiscale relevance and informative encoding in neuronal spike trains","date_published":"2020-02-01T00:00:00Z","quality_controlled":"1","ddc":["004","519","570"],"date_created":"2020-01-28T10:34:00Z","year":"2020","publication":"Journal of Computational Neuroscience","article_processing_charge":"Yes (via OA deal)","volume":48,"status":"public","publication_identifier":{"issn":["0929-5313"],"eissn":["1573-6873"]},"abstract":[{"lang":"eng","text":"Neuronal responses to complex stimuli and tasks can encompass a wide range of time scales. Understanding these responses requires measures that characterize how the information on these response patterns are represented across multiple temporal resolutions. In this paper we propose a metric – which we call multiscale relevance (MSR) – to capture the dynamical variability of the activity of single neurons across different time scales. The MSR is a non-parametric, fully featureless indicator in that it uses only the time stamps of the firing activity without resorting to any a priori covariate or invoking any specific structure in the tuning curve for neural activity. When applied to neural data from the mEC and from the ADn and PoS regions of freely-behaving rodents, we found that neurons having low MSR tend to have low mutual information and low firing sparsity across the correlates that are believed to be encoded by the region of the brain where the recordings were made. In addition, neurons with high MSR contain significant information on spatial navigation and allow to decode spatial position or head direction as efficiently as those neurons whose firing activity has high mutual information with the covariate to be decoded and significantly better than the set of neurons with high local variations in their interspike intervals. Given these results, we propose that the MSR can be used as a measure to rank and select neurons for their information content without the need to appeal to any a priori covariate."}],"doi":"10.1007/s10827-020-00740-x","isi":1,"month":"02","acknowledgement":"This research was supported by the Kavli Foundation and the Centre of Excellence scheme of the Research Council of Norway (Centre for Neural Computation). RJC is currently receiving funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Grant Agreement No. 754411.","publication_status":"published","day":"01","ec_funded":1,"publisher":"Springer Nature","intvolume":"        48","page":"85-102","article_type":"original","language":[{"iso":"eng"}]},{"publisher":"Institute of Science and Technology Austria","date_published":"2020-01-28T00:00:00Z","keyword":["Matlab scripts","analysis of microfluidics","mathematical model"],"title":"Matlab scripts for the Paper: Gene Amplification as a Form of Population-Level Gene Expression regulation","date_created":"2020-01-28T10:41:49Z","article_processing_charge":"No","contributor":[{"last_name":"Guet","id":"47F8433E-F248-11E8-B48F-1D18A9856A87","first_name":"Calin C","contributor_type":"project_leader","orcid":"0000-0001-6220-2052"}],"year":"2020","status":"public","_id":"7383","doi":"10.15479/AT:ISTA:7383","abstract":[{"text":"Organisms cope with change by employing transcriptional regulators. However, when faced with rare environments, the evolution of transcriptional regulators and their promoters may be too slow. We ask whether the intrinsic instability of gene duplication and amplification provides a generic alternative to canonical gene regulation. By real-time monitoring of gene copy number mutations in E. coli, we show that gene duplications and amplifications enable adaptation to fluctuating environments by rapidly generating copy number, and hence expression level, polymorphism. This ‘amplification-mediated gene expression tuning’ occurs on timescales similar to canonical gene regulation and can deal with rapid environmental changes. Mathematical modeling shows that amplifications also tune gene expression in stochastic environments where transcription factor-based schemes are hard to evolve or maintain. The fleeting nature of gene amplifications gives rise to a generic population-level mechanism that relies on genetic heterogeneity to rapidly tune expression of any gene, without leaving any genomic signature.","lang":"eng"}],"file_date_updated":"2020-07-14T12:47:57Z","type":"research_data","month":"01","related_material":{"record":[{"status":"public","id":"7652","relation":"used_in_publication"}]},"citation":{"ieee":"R. Grah, “Matlab scripts for the Paper: Gene Amplification as a Form of Population-Level Gene Expression regulation.” Institute of Science and Technology Austria, 2020.","chicago":"Grah, Rok. “Matlab Scripts for the Paper: Gene Amplification as a Form of Population-Level Gene Expression Regulation.” Institute of Science and Technology Austria, 2020. <a href=\"https://doi.org/10.15479/AT:ISTA:7383\">https://doi.org/10.15479/AT:ISTA:7383</a>.","ama":"Grah R. Matlab scripts for the Paper: Gene Amplification as a Form of Population-Level Gene Expression regulation. 2020. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:7383\">10.15479/AT:ISTA:7383</a>","short":"R. Grah, (2020).","mla":"Grah, Rok. <i>Matlab Scripts for the Paper: Gene Amplification as a Form of Population-Level Gene Expression Regulation</i>. Institute of Science and Technology Austria, 2020, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:7383\">10.15479/AT:ISTA:7383</a>.","apa":"Grah, R. (2020). Matlab scripts for the Paper: Gene Amplification as a Form of Population-Level Gene Expression regulation. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:7383\">https://doi.org/10.15479/AT:ISTA:7383</a>","ista":"Grah R. 2020. Matlab scripts for the Paper: Gene Amplification as a Form of Population-Level Gene Expression regulation, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:7383\">10.15479/AT:ISTA:7383</a>."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","day":"28","has_accepted_license":"1","author":[{"orcid":"0000-0003-2539-3560","id":"483E70DE-F248-11E8-B48F-1D18A9856A87","first_name":"Rok","full_name":"Grah, Rok","last_name":"Grah"}],"oa":1,"oa_version":"Published Version","date_updated":"2024-02-21T12:42:31Z","department":[{"_id":"CaGu"},{"_id":"GaTk"}],"file":[{"access_level":"open_access","date_created":"2020-01-28T10:39:40Z","file_id":"7384","file_name":"Scripts.zip","file_size":73363365,"date_updated":"2020-07-14T12:47:57Z","content_type":"application/zip","relation":"main_file","checksum":"9d292cf5207b3829225f44c044cdb3fd","creator":"rgrah"},{"relation":"main_file","checksum":"4076ceab32ef588cc233802bab24c1ab","creator":"rgrah","file_name":"READ_ME_MAIN.txt","file_size":962,"content_type":"text/plain","date_updated":"2020-07-14T12:47:57Z","access_level":"open_access","date_created":"2020-01-28T10:39:30Z","file_id":"7385"}]},{"_id":"7387","external_id":{"pmid":["31959972"],"isi":["000508584700007"]},"scopus_import":"1","type":"journal_article","date_updated":"2023-10-06T12:22:38Z","oa_version":"Submitted Version","department":[{"_id":"MaLo"}],"citation":{"ieee":"N. S. Baranova <i>et al.</i>, “Diffusion and capture permits dynamic coupling between treadmilling FtsZ filaments and cell division proteins,” <i>Nature Microbiology</i>, vol. 5. Springer Nature, pp. 407–417, 2020.","short":"N.S. Baranova, P. Radler, V.M. Hernández-Rocamora, C. Alfonso, M.D. Lopez Pelegrin, G. Rivas, W. Vollmer, M. Loose, Nature Microbiology 5 (2020) 407–417.","ama":"Baranova NS, Radler P, Hernández-Rocamora VM, et al. Diffusion and capture permits dynamic coupling between treadmilling FtsZ filaments and cell division proteins. <i>Nature Microbiology</i>. 2020;5:407-417. doi:<a href=\"https://doi.org/10.1038/s41564-019-0657-5\">10.1038/s41564-019-0657-5</a>","chicago":"Baranova, Natalia S., Philipp Radler, Víctor M. Hernández-Rocamora, Carlos Alfonso, Maria D Lopez Pelegrin, Germán Rivas, Waldemar Vollmer, and Martin Loose. “Diffusion and Capture Permits Dynamic Coupling between Treadmilling FtsZ Filaments and Cell Division Proteins.” <i>Nature Microbiology</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41564-019-0657-5\">https://doi.org/10.1038/s41564-019-0657-5</a>.","ista":"Baranova NS, Radler P, Hernández-Rocamora VM, Alfonso C, Lopez Pelegrin MD, Rivas G, Vollmer W, Loose M. 2020. Diffusion and capture permits dynamic coupling between treadmilling FtsZ filaments and cell division proteins. Nature Microbiology. 5, 407–417.","apa":"Baranova, N. S., Radler, P., Hernández-Rocamora, V. M., Alfonso, C., Lopez Pelegrin, M. D., Rivas, G., … Loose, M. (2020). Diffusion and capture permits dynamic coupling between treadmilling FtsZ filaments and cell division proteins. <i>Nature Microbiology</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41564-019-0657-5\">https://doi.org/10.1038/s41564-019-0657-5</a>","mla":"Baranova, Natalia S., et al. “Diffusion and Capture Permits Dynamic Coupling between Treadmilling FtsZ Filaments and Cell Division Proteins.” <i>Nature Microbiology</i>, vol. 5, Springer Nature, 2020, pp. 407–17, doi:<a href=\"https://doi.org/10.1038/s41564-019-0657-5\">10.1038/s41564-019-0657-5</a>."},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","oa":1,"author":[{"orcid":"0000-0002-3086-9124","full_name":"Baranova, Natalia S.","id":"38661662-F248-11E8-B48F-1D18A9856A87","first_name":"Natalia S.","last_name":"Baranova"},{"last_name":"Radler","orcid":"0000-0001-9198-2182 ","id":"40136C2A-F248-11E8-B48F-1D18A9856A87","first_name":"Philipp","full_name":"Radler, Philipp"},{"last_name":"Hernández-Rocamora","full_name":"Hernández-Rocamora, Víctor M.","first_name":"Víctor M."},{"full_name":"Alfonso, Carlos","first_name":"Carlos","last_name":"Alfonso"},{"id":"319AA9CE-F248-11E8-B48F-1D18A9856A87","first_name":"Maria D","full_name":"Lopez Pelegrin, Maria D","last_name":"Lopez Pelegrin"},{"full_name":"Rivas, Germán","first_name":"Germán","last_name":"Rivas"},{"last_name":"Vollmer","full_name":"Vollmer, Waldemar","first_name":"Waldemar"},{"last_name":"Loose","first_name":"Martin","full_name":"Loose, Martin","id":"462D4284-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-7309-9724"}],"project":[{"name":"Self-Organization of the Bacterial Cell","grant_number":"679239","call_identifier":"H2020","_id":"2595697A-B435-11E9-9278-68D0E5697425"},{"_id":"259B655A-B435-11E9-9278-68D0E5697425","name":"Reconstitution of bacterial cell wall sythesis","grant_number":"LT000824/2016"},{"_id":"2596EAB6-B435-11E9-9278-68D0E5697425","grant_number":"ALTF 2015-1163","name":"Synthesis of bacterial cell wall"}],"date_published":"2020-01-20T00:00:00Z","title":"Diffusion and capture permits dynamic coupling between treadmilling FtsZ filaments and cell division proteins","quality_controlled":"1","date_created":"2020-01-28T16:14:41Z","main_file_link":[{"open_access":"1","url":"http://europepmc.org/article/PMC/7048620"}],"year":"2020","publication":"Nature Microbiology","volume":5,"article_processing_charge":"No","pmid":1,"status":"public","publication_identifier":{"issn":["2058-5276"]},"doi":"10.1038/s41564-019-0657-5","abstract":[{"text":"Most bacteria accomplish cell division with the help of a dynamic protein complex called the divisome, which spans the cell envelope in the plane of division. Assembly and activation of this machinery are coordinated by the tubulin-related GTPase FtsZ, which was found to form treadmilling filaments on supported bilayers in vitro1, as well as in live cells, in which filaments circle around the cell division site2,3. Treadmilling of FtsZ is thought to actively move proteins around the division septum, thereby distributing peptidoglycan synthesis and coordinating the inward growth of the septum to form the new poles of the daughter cells4. However, the molecular mechanisms underlying this function are largely unknown. Here, to study how FtsZ polymerization dynamics are coupled to downstream proteins, we reconstituted part of the bacterial cell division machinery using its purified components FtsZ, FtsA and truncated transmembrane proteins essential for cell division. We found that the membrane-bound cytosolic peptides of FtsN and FtsQ co-migrated with treadmilling FtsZ–FtsA filaments, but despite their directed collective behaviour, individual peptides showed random motion and transient confinement. Our work suggests that divisome proteins follow treadmilling FtsZ filaments by a diffusion-and-capture mechanism, which can give rise to a moving zone of signalling activity at the division site.","lang":"eng"}],"isi":1,"related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"14280"}],"link":[{"url":"https://ist.ac.at/en/news/little-cell-big-cover-story/","relation":"press_release","description":"News on IST Homepage"}]},"month":"01","acknowledgement":"We acknowledge members of the Loose laboratory at IST Austria for helpful discussions—in particular, P. Caldas for help with the treadmilling analysis, M. Jimenez, A. Raso and N. Ropero for providing Alexa Fluor 488- and Alexa Fluor 647-labelled FtsA for the MST and analytical ultracentrifugation experiments. We thank C. You for providing the DODA-tris-NTA phospholipids, as well as J. Piehler and C. Richter (Department of Biology, University of Osnabruck, Germany) for the SLIMfast single-molecule tracking software and help with the confinement analysis. We thank J. Errington and H. Murray (both at Newcastle University, UK) for critical reading of the manuscript, and J. Brugués (MPI-CBG and MPI-PKS, Dresden, Germany) for help with the MATLAB programming and reading of the manuscript. This work was supported by the European Research Council through grant ERC-2015-StG-679239 to M.L. and grants HFSP LT 000824/2016-L4 and EMBO ALTF 1163-2015 to N.B., a grant from the Ministry of Economy and Competitiveness of the Spanish Government (BFU2016-75471-C2-1-P) to C.A. and G.R., and a Wellcome Trust Senior Investigator award (101824/Z/13/Z) and a grant from the BBSRC (BB/R017409/1) to W.V.","publication_status":"published","day":"20","ec_funded":1,"publisher":"Springer Nature","intvolume":"         5","page":"407-417","article_type":"letter_note","language":[{"iso":"eng"}]}]