[{"publication":"Evolution Letters","year":"2021","language":[{"iso":"eng"}],"day":"07","ec_funded":1,"file_date_updated":"2021-10-15T08:26:02Z","issue":"3","author":[{"first_name":"Eva L.","last_name":"Koch","full_name":"Koch, Eva L."},{"full_name":"Morales, Hernán E.","last_name":"Morales","first_name":"Hernán E."},{"full_name":"Larsson, Jenny","last_name":"Larsson","first_name":"Jenny"},{"full_name":"Westram, Anja M","id":"3C147470-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1050-4969","first_name":"Anja M","last_name":"Westram"},{"first_name":"Rui","last_name":"Faria","full_name":"Faria, Rui"},{"last_name":"Lemmon","first_name":"Alan R.","full_name":"Lemmon, Alan R."},{"first_name":"E. Moriarty","last_name":"Lemmon","full_name":"Lemmon, E. Moriarty"},{"full_name":"Johannesson, Kerstin","first_name":"Kerstin","last_name":"Johannesson"},{"full_name":"Butlin, Roger K.","first_name":"Roger K.","last_name":"Butlin"}],"date_published":"2021-05-07T00:00:00Z","abstract":[{"lang":"eng","text":"Chromosomal inversions have long been recognized for their role in local adaptation. By suppressing recombination in heterozygous individuals, they can maintain coadapted gene complexes and protect them from homogenizing effects of gene flow. However, to fully understand their importance for local adaptation we need to know their influence on phenotypes under divergent selection. For this, the marine snail Littorina saxatilis provides an ideal study system. Divergent ecotypes adapted to wave action and crab predation occur in close proximity on intertidal shores with gene flow between them. Here, we used F2 individuals obtained from crosses between the ecotypes to test for associations between genomic regions and traits distinguishing the Crab‐/Wave‐adapted ecotypes including size, shape, shell thickness, and behavior. We show that most of these traits are influenced by two previously detected inversion regions that are divergent between ecotypes. We thus gain a better understanding of one important underlying mechanism responsible for the rapid and repeated formation of ecotypes: divergent selection acting on inversions. We also found that some inversions contributed to more than one trait suggesting that they may contain several loci involved in adaptation, consistent with the hypothesis that suppression of recombination within inversions facilitates differentiation in the presence of gene flow."}],"volume":5,"article_type":"original","project":[{"_id":"265B41B8-B435-11E9-9278-68D0E5697425","name":"Theoretical and empirical approaches to understanding Parallel Adaptation","call_identifier":"H2020","grant_number":"797747"}],"date_created":"2021-05-16T22:01:47Z","file":[{"success":1,"content_type":"application/pdf","date_updated":"2021-10-15T08:26:02Z","file_size":3021108,"access_level":"open_access","file_name":"2021_EvolutionLetters_Koch.pdf","file_id":"10142","relation":"main_file","checksum":"023b1608e311f0fda30593ba3d0a4e0b","creator":"cchlebak","date_created":"2021-10-15T08:26:02Z"}],"publisher":"Wiley","scopus_import":"1","oa_version":"Published Version","month":"05","related_material":{"record":[{"relation":"research_data","id":"12987","status":"public"}]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publication_status":"published","oa":1,"publication_identifier":{"eissn":["2056-3744"]},"ddc":["570"],"date_updated":"2023-08-08T13:34:08Z","has_accepted_license":"1","external_id":{"isi":["000647846200001"]},"doi":"10.1002/evl3.227","intvolume":"         5","_id":"9394","license":"https://creativecommons.org/licenses/by/4.0/","page":"196-213","quality_controlled":"1","acknowledgement":"We are very grateful to Irena Senčić for technical assistance and to Michelle Kortyna and Sean Holland at the Center for Anchored Phylogenomics for assistance with data collection. RKB was funded by the Natural Environment Research Council and by the European Research Council. KJ was funded by the Swedish Research Councils VR and Formas (Linnaeus Grant: 217‐2008‐1719). JL was funded by a studentship from the Leverhulme Centre for Advanced Biological Modelling. AMW was funded by the European Union's Horizon 2020 research and innovation program under Marie Skłodowska‐Curie Grant agreement no. 797747. RF was funded by the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska‐Curie Grant agreement No. 706376 and by FEDER Funds through the Operational Competitiveness Factors Program—COMPETE and by National Funds through FCT—Foundation for Science and Technology within the scope of the project “Hybrabbid” (PTDC/BIA‐EVL/30628/2017‐ POCI‐01‐0145‐FEDER‐030628). We are grateful to other members of the Littorina research group for helpful discussions. We thank Claire Mérot and an anonymous referee for insightful comments on an earlier version. ","department":[{"_id":"NiBa"}],"article_processing_charge":"No","citation":{"apa":"Koch, E. L., Morales, H. E., Larsson, J., Westram, A. M., Faria, R., Lemmon, A. R., … Butlin, R. K. (2021). Genetic variation for adaptive traits is associated with polymorphic inversions in Littorina saxatilis. <i>Evolution Letters</i>. Wiley. <a href=\"https://doi.org/10.1002/evl3.227\">https://doi.org/10.1002/evl3.227</a>","mla":"Koch, Eva L., et al. “Genetic Variation for Adaptive Traits Is Associated with Polymorphic Inversions in Littorina Saxatilis.” <i>Evolution Letters</i>, vol. 5, no. 3, Wiley, 2021, pp. 196–213, doi:<a href=\"https://doi.org/10.1002/evl3.227\">10.1002/evl3.227</a>.","ama":"Koch EL, Morales HE, Larsson J, et al. Genetic variation for adaptive traits is associated with polymorphic inversions in Littorina saxatilis. <i>Evolution Letters</i>. 2021;5(3):196-213. doi:<a href=\"https://doi.org/10.1002/evl3.227\">10.1002/evl3.227</a>","short":"E.L. Koch, H.E. Morales, J. Larsson, A.M. Westram, R. Faria, A.R. Lemmon, E.M. Lemmon, K. Johannesson, R.K. Butlin, Evolution Letters 5 (2021) 196–213.","chicago":"Koch, Eva L., Hernán E. Morales, Jenny Larsson, Anja M Westram, Rui Faria, Alan R. Lemmon, E. Moriarty Lemmon, Kerstin Johannesson, and Roger K. Butlin. “Genetic Variation for Adaptive Traits Is Associated with Polymorphic Inversions in Littorina Saxatilis.” <i>Evolution Letters</i>. Wiley, 2021. <a href=\"https://doi.org/10.1002/evl3.227\">https://doi.org/10.1002/evl3.227</a>.","ista":"Koch EL, Morales HE, Larsson J, Westram AM, Faria R, Lemmon AR, Lemmon EM, Johannesson K, Butlin RK. 2021. Genetic variation for adaptive traits is associated with polymorphic inversions in Littorina saxatilis. Evolution Letters. 5(3), 196–213.","ieee":"E. L. Koch <i>et al.</i>, “Genetic variation for adaptive traits is associated with polymorphic inversions in Littorina saxatilis,” <i>Evolution Letters</i>, vol. 5, no. 3. Wiley, pp. 196–213, 2021."},"isi":1,"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"title":"Genetic variation for adaptive traits is associated with polymorphic inversions in Littorina saxatilis","type":"journal_article","status":"public"},{"date_created":"2021-05-17T12:31:30Z","publisher":"Institute of Science and Technology Austria","file":[{"file_name":"KHuljev_Thesis_corrections.docx","file_size":47799741,"access_level":"closed","date_updated":"2022-05-21T22:30:04Z","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","embargo_to":"open_access","creator":"khuljev","date_created":"2021-05-17T12:29:12Z","checksum":"7f98532f5324a0b2f3fa8de2967baa19","relation":"source_file","file_id":"9398"},{"file_size":16542131,"access_level":"open_access","file_name":"new_KHuljev_Thesis_corrections.pdf","content_type":"application/pdf","date_updated":"2022-05-21T22:30:04Z","checksum":"bf512f8a1e572a543778fc4b227c01ba","relation":"main_file","date_created":"2021-05-18T14:50:28Z","creator":"khuljev","file_id":"9401","embargo":"2022-05-20"}],"supervisor":[{"orcid":"0000-0002-0912-4566","last_name":"Heisenberg","first_name":"Carl-Philipp J","full_name":"Heisenberg, Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87"}],"language":[{"iso":"eng"}],"year":"2021","day":"18","file_date_updated":"2022-05-21T22:30:04Z","author":[{"last_name":"Huljev","first_name":"Karla","full_name":"Huljev, Karla","id":"44C6F6A6-F248-11E8-B48F-1D18A9856A87"}],"date_published":"2021-05-18T00:00:00Z","abstract":[{"text":"Accumulation of interstitial fluid (IF) between embryonic cells is a common phenomenon in vertebrate embryogenesis. Unlike other model systems, where these accumulations coalesce into a large central cavity – the blastocoel, in zebrafish, IF is more uniformly distributed between the deep cells (DC) before the onset of gastrulation. This is likely due to the presence of a large extraembryonic structure – the yolk cell (YC) at the position where the blastocoel typically forms in other model organisms. IF has long been speculated to play a role in tissue morphogenesis during embryogenesis, but direct evidence supporting such function is still sparse. Here we show that the relocalization of IF to the interface between the YC and DC/epiblast is critical for axial mesendoderm (ME) cell protrusion formation and migration along this interface, a key process in embryonic axis formation. We further demonstrate that axial ME cell migration and IF relocalization engage in a positive feedback loop, where axial ME migration triggers IF accumulation ahead of the advancing axial ME tissue by mechanically compressing the overlying epiblast cell layer. Upon compression, locally induced flow relocalizes the IF through the porous epiblast tissue resulting in an IF accumulation ahead of the leading axial ME. This IF accumulation, in turn, promotes cell protrusion formation and migration of the leading axial ME cells, thereby facilitating axial ME extension. Our findings reveal a central role of dynamic IF relocalization in orchestrating germ layer morphogenesis during gastrulation.","lang":"eng"}],"doi":"10.15479/at:ista:9397","_id":"9397","page":"101","degree_awarded":"PhD","department":[{"_id":"CaHe"},{"_id":"GradSch"}],"citation":{"ista":"Huljev K. 2021. Coordinated spatiotemporal reorganization of interstitial fluid is required for axial mesendoderm migration in zebrafish gastrulation. Institute of Science and Technology Austria.","ieee":"K. Huljev, “Coordinated spatiotemporal reorganization of interstitial fluid is required for axial mesendoderm migration in zebrafish gastrulation,” Institute of Science and Technology Austria, 2021.","short":"K. Huljev, Coordinated Spatiotemporal Reorganization of Interstitial Fluid Is Required for Axial Mesendoderm Migration in Zebrafish Gastrulation, Institute of Science and Technology Austria, 2021.","chicago":"Huljev, Karla. “Coordinated Spatiotemporal Reorganization of Interstitial Fluid Is Required for Axial Mesendoderm Migration in Zebrafish Gastrulation.” Institute of Science and Technology Austria, 2021. <a href=\"https://doi.org/10.15479/at:ista:9397\">https://doi.org/10.15479/at:ista:9397</a>.","ama":"Huljev K. Coordinated spatiotemporal reorganization of interstitial fluid is required for axial mesendoderm migration in zebrafish gastrulation. 2021. doi:<a href=\"https://doi.org/10.15479/at:ista:9397\">10.15479/at:ista:9397</a>","mla":"Huljev, Karla. <i>Coordinated Spatiotemporal Reorganization of Interstitial Fluid Is Required for Axial Mesendoderm Migration in Zebrafish Gastrulation</i>. Institute of Science and Technology Austria, 2021, doi:<a href=\"https://doi.org/10.15479/at:ista:9397\">10.15479/at:ista:9397</a>.","apa":"Huljev, K. (2021). <i>Coordinated spatiotemporal reorganization of interstitial fluid is required for axial mesendoderm migration in zebrafish gastrulation</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:9397\">https://doi.org/10.15479/at:ista:9397</a>"},"article_processing_charge":"No","title":"Coordinated spatiotemporal reorganization of interstitial fluid is required for axial mesendoderm migration in zebrafish gastrulation","type":"dissertation","status":"public","oa_version":"Published Version","month":"05","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","oa":1,"publication_status":"published","publication_identifier":{"issn":["2663-337X"]},"ddc":["571"],"date_updated":"2023-09-07T13:32:32Z","has_accepted_license":"1","alternative_title":["ISTA Thesis"]},{"file_date_updated":"2023-11-07T08:27:23Z","issue":"10","author":[{"first_name":"Laura","last_name":"Schmid","orcid":"0000-0002-6978-7329","id":"38B437DE-F248-11E8-B48F-1D18A9856A87","full_name":"Schmid, Laura"},{"full_name":"Chatterjee, Krishnendu","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4561-241X","first_name":"Krishnendu","last_name":"Chatterjee"},{"id":"2FDF8F3C-F248-11E8-B48F-1D18A9856A87","full_name":"Hilbe, Christian","last_name":"Hilbe","first_name":"Christian","orcid":"0000-0001-5116-955X"},{"first_name":"Martin A.","last_name":"Nowak","full_name":"Nowak, Martin A."}],"volume":5,"abstract":[{"text":"Direct and indirect reciprocity are key mechanisms for the evolution of cooperation. Direct reciprocity means that individuals use their own experience to decide whether to cooperate with another person. Indirect reciprocity means that they also consider the experiences of others. Although these two mechanisms are intertwined, they are typically studied in isolation. Here, we introduce a mathematical framework that allows us to explore both kinds of reciprocity simultaneously. We show that the well-known ‘generous tit-for-tat’ strategy of direct reciprocity has a natural analogue in indirect reciprocity, which we call ‘generous scoring’. Using an equilibrium analysis, we characterize under which conditions either of the two strategies can maintain cooperation. With simulations, we additionally explore which kind of reciprocity evolves when members of a population engage in social learning to adapt to their environment. Our results draw unexpected connections between direct and indirect reciprocity while highlighting important differences regarding their evolvability.","lang":"eng"}],"date_published":"2021-05-13T00:00:00Z","publication":"Nature Human Behaviour","day":"13","language":[{"iso":"eng"}],"year":"2021","ec_funded":1,"publisher":"Springer Nature","file":[{"file_name":"2021_NatureHumanBehaviour_Schmid_accepted.pdf","file_size":5232761,"access_level":"open_access","date_updated":"2023-11-07T08:27:23Z","content_type":"application/pdf","creator":"dernst","date_created":"2023-11-07T08:27:23Z","relation":"main_file","checksum":"34f55e173f90dc1dab731063458ac780","file_id":"14496","success":1}],"pmid":1,"scopus_import":"1","project":[{"name":"Formal Methods for Stochastic Models: Algorithms and Applications","_id":"0599E47C-7A3F-11EA-A408-12923DDC885E","call_identifier":"H2020","grant_number":"863818"},{"grant_number":"279307","call_identifier":"FP7","name":"Quantitative Graph Games: Theory and Applications","_id":"2581B60A-B435-11E9-9278-68D0E5697425"}],"date_created":"2021-05-18T16:56:57Z","article_type":"original","has_accepted_license":"1","oa_version":"Submitted Version","month":"05","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","related_material":{"link":[{"url":"https://ist.ac.at/en/news/the-emergence-of-cooperation/","relation":"press_release","description":"News on IST Homepage"}],"record":[{"status":"public","relation":"dissertation_contains","id":"10293"}]},"publication_status":"published","oa":1,"date_updated":"2025-07-14T09:10:09Z","ddc":["000"],"publication_identifier":{"eissn":["2397-3374"]},"article_processing_charge":"No","citation":{"ama":"Schmid L, Chatterjee K, Hilbe C, Nowak MA. A unified framework of direct and indirect reciprocity. <i>Nature Human Behaviour</i>. 2021;5(10):1292–1302. doi:<a href=\"https://doi.org/10.1038/s41562-021-01114-8\">10.1038/s41562-021-01114-8</a>","short":"L. Schmid, K. Chatterjee, C. Hilbe, M.A. Nowak, Nature Human Behaviour 5 (2021) 1292–1302.","chicago":"Schmid, Laura, Krishnendu Chatterjee, Christian Hilbe, and Martin A. Nowak. “A Unified Framework of Direct and Indirect Reciprocity.” <i>Nature Human Behaviour</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s41562-021-01114-8\">https://doi.org/10.1038/s41562-021-01114-8</a>.","mla":"Schmid, Laura, et al. “A Unified Framework of Direct and Indirect Reciprocity.” <i>Nature Human Behaviour</i>, vol. 5, no. 10, Springer Nature, 2021, pp. 1292–1302, doi:<a href=\"https://doi.org/10.1038/s41562-021-01114-8\">10.1038/s41562-021-01114-8</a>.","apa":"Schmid, L., Chatterjee, K., Hilbe, C., &#38; Nowak, M. A. (2021). A unified framework of direct and indirect reciprocity. <i>Nature Human Behaviour</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41562-021-01114-8\">https://doi.org/10.1038/s41562-021-01114-8</a>","ista":"Schmid L, Chatterjee K, Hilbe C, Nowak MA. 2021. A unified framework of direct and indirect reciprocity. Nature Human Behaviour. 5(10), 1292–1302.","ieee":"L. Schmid, K. Chatterjee, C. Hilbe, and M. A. Nowak, “A unified framework of direct and indirect reciprocity,” <i>Nature Human Behaviour</i>, vol. 5, no. 10. Springer Nature, pp. 1292–1302, 2021."},"isi":1,"title":"A unified framework of direct and indirect reciprocity","status":"public","type":"journal_article","doi":"10.1038/s41562-021-01114-8","external_id":{"pmid":["33986519"],"isi":["000650304000002"]},"_id":"9402","page":"1292–1302","intvolume":"         5","acknowledgement":"This work was supported by the European Research Council CoG 863818 (ForM-SMArt) (to K.C.), the European Research Council Start Grant 279307: Graph Games (to K.C.), and the European Research Council Starting Grant 850529: E-DIRECT (to C.H.). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.","quality_controlled":"1","department":[{"_id":"KrCh"},{"_id":"GradSch"}]},{"oa":1,"date_updated":"2023-02-23T13:57:04Z","publication_identifier":{"isbn":["978-0-262-04559-9"]},"publication":"Deliberate Ignorance: Choosing Not To Know","oa_version":"Published Version","month":"03","day":"01","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","language":[{"iso":"eng"}],"year":"2021","author":[{"id":"38B437DE-F248-11E8-B48F-1D18A9856A87","full_name":"Schmid, Laura","orcid":"0000-0002-6978-7329","last_name":"Schmid","first_name":"Laura"},{"first_name":"Christian","last_name":"Hilbe","full_name":"Hilbe, Christian"}],"abstract":[{"lang":"eng","text":"Optimal decision making requires individuals to know their available options and to anticipate correctly what consequences these options have. In many social interactions, however, we refrain from gathering all relevant information, even if this information would help us make better decisions and is costless to obtain. This chapter examines several examples of “deliberate ignorance.” Two simple models are proposed to illustrate how ignorance can evolve among self-interested and payoff - maximizing individuals, and open problems are highlighted that lie ahead for future research to explore."}],"volume":29,"date_published":"2021-03-01T00:00:00Z","quality_controlled":"1","department":[{"_id":"GradSch"},{"_id":"KrCh"}],"editor":[{"last_name":"Hertwig","first_name":"Ralph","full_name":"Hertwig, Ralph"},{"full_name":"Engel, Christoph","last_name":"Engel","first_name":"Christoph"}],"date_created":"2021-05-19T12:25:42Z","_id":"9403","page":"139-152","intvolume":"        29","series_title":"Strüngmann Forum Reports","title":"The evolution of strategic ignorance in strategic interaction","status":"public","type":"book_chapter","publisher":"MIT Press","citation":{"ista":"Schmid L, Hilbe C. 2021.The evolution of strategic ignorance in strategic interaction. In: Deliberate Ignorance: Choosing Not To Know. vol. 29, 139–152.","ieee":"L. Schmid and C. Hilbe, “The evolution of strategic ignorance in strategic interaction,” in <i>Deliberate Ignorance: Choosing Not To Know</i>, vol. 29, R. Hertwig and C. Engel, Eds. MIT Press, 2021, pp. 139–152.","ama":"Schmid L, Hilbe C. The evolution of strategic ignorance in strategic interaction. In: Hertwig R, Engel C, eds. <i>Deliberate Ignorance: Choosing Not To Know</i>. Vol 29. Strüngmann Forum Reports. MIT Press; 2021:139-152.","chicago":"Schmid, Laura, and Christian Hilbe. “The Evolution of Strategic Ignorance in Strategic Interaction.” In <i>Deliberate Ignorance: Choosing Not To Know</i>, edited by Ralph Hertwig and Christoph Engel, 29:139–52. Strüngmann Forum Reports. MIT Press, 2021.","short":"L. Schmid, C. Hilbe, in:, R. Hertwig, C. Engel (Eds.), Deliberate Ignorance: Choosing Not To Know, MIT Press, 2021, pp. 139–152.","mla":"Schmid, Laura, and Christian Hilbe. “The Evolution of Strategic Ignorance in Strategic Interaction.” <i>Deliberate Ignorance: Choosing Not To Know</i>, edited by Ralph Hertwig and Christoph Engel, vol. 29, MIT Press, 2021, pp. 139–52.","apa":"Schmid, L., &#38; Hilbe, C. (2021). The evolution of strategic ignorance in strategic interaction. In R. Hertwig &#38; C. Engel (Eds.), <i>Deliberate Ignorance: Choosing Not To Know</i> (Vol. 29, pp. 139–152). MIT Press."},"main_file_link":[{"url":"https://esforum.de/publications/PDFs/sfr29/SFR29_09_Hilbe%20and%20Schmid.pdf","open_access":"1"}],"article_processing_charge":"No"},{"article_number":"2586","has_accepted_license":"1","publication_status":"published","oa":1,"ddc":["570"],"date_updated":"2023-08-08T13:45:13Z","publication_identifier":{"eissn":["20411723"]},"oa_version":"Published Version","month":"05","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","related_material":{"link":[{"url":"https://ist.ac.at/en/news/smashing-the-covid-curve/","description":"News on IST Homepage","relation":"press_release"}]},"title":"Discontinuous epidemic transition due to limited testing","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"status":"public","type":"journal_article","article_processing_charge":"No","citation":{"short":"D. Scarselli, N.B. Budanur, M. Timme, B. Hof, Nature Communications 12 (2021).","ama":"Scarselli D, Budanur NB, Timme M, Hof B. Discontinuous epidemic transition due to limited testing. <i>Nature Communications</i>. 2021;12(1). doi:<a href=\"https://doi.org/10.1038/s41467-021-22725-9\">10.1038/s41467-021-22725-9</a>","chicago":"Scarselli, Davide, Nazmi B Budanur, Marc Timme, and Björn Hof. “Discontinuous Epidemic Transition Due to Limited Testing.” <i>Nature Communications</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s41467-021-22725-9\">https://doi.org/10.1038/s41467-021-22725-9</a>.","apa":"Scarselli, D., Budanur, N. B., Timme, M., &#38; Hof, B. (2021). Discontinuous epidemic transition due to limited testing. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-021-22725-9\">https://doi.org/10.1038/s41467-021-22725-9</a>","mla":"Scarselli, Davide, et al. “Discontinuous Epidemic Transition Due to Limited Testing.” <i>Nature Communications</i>, vol. 12, no. 1, 2586, Springer Nature, 2021, doi:<a href=\"https://doi.org/10.1038/s41467-021-22725-9\">10.1038/s41467-021-22725-9</a>.","ista":"Scarselli D, Budanur NB, Timme M, Hof B. 2021. Discontinuous epidemic transition due to limited testing. Nature Communications. 12(1), 2586.","ieee":"D. Scarselli, N. B. Budanur, M. Timme, and B. Hof, “Discontinuous epidemic transition due to limited testing,” <i>Nature Communications</i>, vol. 12, no. 1. Springer Nature, 2021."},"isi":1,"acknowledgement":"The authors thank Malte Schröder for valuable discussions and creating the scale-free network topologies. B.H. thanks Mukund Vasudevan for helpful discussion. The research by M.T. was supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany´s Excellence Strategy–EXC-2068–390729961–Cluster of Excellence Physics of Life of TU Dresden.","quality_controlled":"1","department":[{"_id":"BjHo"}],"doi":"10.1038/s41467-021-22725-9","external_id":{"isi":["000687305500044"]},"_id":"9407","intvolume":"        12","author":[{"full_name":"Scarselli, Davide","id":"40315C30-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5227-4271","last_name":"Scarselli","first_name":"Davide"},{"last_name":"Budanur","first_name":"Nazmi B","orcid":"0000-0003-0423-5010","full_name":"Budanur, Nazmi B","id":"3EA1010E-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Timme, Marc","first_name":"Marc","last_name":"Timme"},{"id":"3A374330-F248-11E8-B48F-1D18A9856A87","full_name":"Hof, Björn","orcid":"0000-0003-2057-2754","first_name":"Björn","last_name":"Hof"}],"abstract":[{"text":"High impact epidemics constitute one of the largest threats humanity is facing in the 21st century. In the absence of pharmaceutical interventions, physical distancing together with testing, contact tracing and quarantining are crucial in slowing down epidemic dynamics. Yet, here we show that if testing capacities are limited, containment may fail dramatically because such combined countermeasures drastically change the rules of the epidemic transition: Instead of continuous, the response to countermeasures becomes discontinuous. Rather than following the conventional exponential growth, the outbreak that is initially strongly suppressed eventually accelerates and scales faster than exponential during an explosive growth period. As a consequence, containment measures either suffice to stop the outbreak at low total case numbers or fail catastrophically if marginally too weak, thus implying large uncertainties in reliably estimating overall epidemic dynamics, both during initial phases and during second wave scenarios.","lang":"eng"}],"volume":12,"date_published":"2021-05-10T00:00:00Z","file_date_updated":"2021-05-25T14:18:40Z","issue":"1","publication":"Nature Communications","day":"10","language":[{"iso":"eng"}],"year":"2021","scopus_import":"1","file":[{"success":1,"file_size":1176573,"access_level":"open_access","file_name":"2021_NatureCommunications_Scarselli.pdf","content_type":"application/pdf","date_updated":"2021-05-25T14:18:40Z","checksum":"fe26c1b8a7da1ae07a6c03f80ff06ea1","relation":"main_file","creator":"kschuh","date_created":"2021-05-25T14:18:40Z","file_id":"9426"}],"publisher":"Springer Nature","article_type":"original","date_created":"2021-05-23T22:01:42Z"},{"file_date_updated":"2021-05-25T15:08:49Z","issue":"6","author":[{"full_name":"Feng, Xudong","first_name":"Xudong","last_name":"Feng"},{"first_name":"Jiafeng","last_name":"Liu","full_name":"Liu, Jiafeng"},{"last_name":"Wang","first_name":"Huamin","full_name":"Wang, Huamin"},{"full_name":"Yang, Yin","first_name":"Yin","last_name":"Yang"},{"last_name":"Bao","first_name":"Hujun","full_name":"Bao, Hujun"},{"full_name":"Bickel, Bernd","id":"49876194-F248-11E8-B48F-1D18A9856A87","first_name":"Bernd","last_name":"Bickel","orcid":"0000-0001-6511-9385"},{"full_name":"Xu, Weiwei","first_name":"Weiwei","last_name":"Xu"}],"date_published":"2021-06-01T00:00:00Z","volume":27,"abstract":[{"lang":"eng","text":"We present a computational design system that assists users to model, optimize, and fabricate quad-robots with soft skins. Our system addresses the challenging task of predicting their physical behavior by fully integrating the multibody dynamics of the mechanical skeleton and the elastic behavior of the soft skin. The developed motion control strategy uses an alternating optimization scheme to avoid expensive full space time-optimization, interleaving space-time optimization for the skeleton, and frame-by-frame optimization for the full dynamics. The output are motor torques to drive the robot to achieve a user prescribed motion trajectory. We also provide a collection of convenient engineering tools and empirical manufacturing guidance to support the fabrication of the designed quad-robot. We validate the feasibility of designs generated with our system through physics simulations and with a physically-fabricated prototype."}],"publication":"IEEE Transactions on Visualization and Computer Graphics","language":[{"iso":"eng"}],"year":"2021","day":"01","ec_funded":1,"pmid":1,"file":[{"success":1,"file_id":"9427","checksum":"a78e6ac94e33ade4ffaea66943d5f7dc","relation":"main_file","creator":"kschuh","date_created":"2021-05-25T15:08:49Z","content_type":"application/pdf","date_updated":"2021-05-25T15:08:49Z","file_size":6183002,"access_level":"open_access","file_name":"2021_TVCG_Feng.pdf"}],"publisher":"IEEE","scopus_import":"1","project":[{"name":"MATERIALIZABLE: Intelligent fabrication-oriented Computational Design and Modeling","_id":"24F9549A-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"715767"}],"date_created":"2021-05-23T22:01:42Z","has_accepted_license":"1","article_number":"2881-2895","oa_version":"Published Version","month":"06","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publication_status":"published","oa":1,"publication_identifier":{"eissn":["10772626"],"issn":["19410506"]},"date_updated":"2023-08-08T13:45:46Z","ddc":["000"],"article_processing_charge":"No","citation":{"ieee":"X. Feng <i>et al.</i>, “Computational design of skinned Quad-Robots,” <i>IEEE Transactions on Visualization and Computer Graphics</i>, vol. 27, no. 6. IEEE, 2021.","ista":"Feng X, Liu J, Wang H, Yang Y, Bao H, Bickel B, Xu W. 2021. Computational design of skinned Quad-Robots. IEEE Transactions on Visualization and Computer Graphics. 27(6), 2881–2895.","short":"X. Feng, J. Liu, H. Wang, Y. Yang, H. Bao, B. Bickel, W. Xu, IEEE Transactions on Visualization and Computer Graphics 27 (2021).","chicago":"Feng, Xudong, Jiafeng Liu, Huamin Wang, Yin Yang, Hujun Bao, Bernd Bickel, and Weiwei Xu. “Computational Design of Skinned Quad-Robots.” <i>IEEE Transactions on Visualization and Computer Graphics</i>. IEEE, 2021. <a href=\"https://doi.org/10.1109/TVCG.2019.2957218\">https://doi.org/10.1109/TVCG.2019.2957218</a>.","ama":"Feng X, Liu J, Wang H, et al. Computational design of skinned Quad-Robots. <i>IEEE Transactions on Visualization and Computer Graphics</i>. 2021;27(6). doi:<a href=\"https://doi.org/10.1109/TVCG.2019.2957218\">10.1109/TVCG.2019.2957218</a>","mla":"Feng, Xudong, et al. “Computational Design of Skinned Quad-Robots.” <i>IEEE Transactions on Visualization and Computer Graphics</i>, vol. 27, no. 6, 2881–2895, IEEE, 2021, doi:<a href=\"https://doi.org/10.1109/TVCG.2019.2957218\">10.1109/TVCG.2019.2957218</a>.","apa":"Feng, X., Liu, J., Wang, H., Yang, Y., Bao, H., Bickel, B., &#38; Xu, W. (2021). Computational design of skinned Quad-Robots. <i>IEEE Transactions on Visualization and Computer Graphics</i>. IEEE. <a href=\"https://doi.org/10.1109/TVCG.2019.2957218\">https://doi.org/10.1109/TVCG.2019.2957218</a>"},"isi":1,"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"title":"Computational design of skinned Quad-Robots","status":"public","type":"journal_article","external_id":{"pmid":["31804937"],"isi":["000649620700009"]},"doi":"10.1109/TVCG.2019.2957218","intvolume":"        27","_id":"9408","quality_controlled":"1","acknowledgement":"The authors would like to thank anonymous reviewers for their constructive comments. Weiwei Xu is partially supported by Zhejiang Lab. Yin Yang is partially spported by NSF under Grant Nos. CHS 1845024 and 1717972. Weiwei Xu and Hujun Bao are supported by Fundamental Research Funds for the Central Universities. This project has received funding from the European Research Council (ERC) under the European Unions Horizon 2020 research and innovation programme (Grant agreement No 715767).","department":[{"_id":"BeBi"}]},{"file_date_updated":"2021-05-25T14:09:03Z","issue":"5","author":[{"first_name":"Mato","last_name":"Lagator","id":"345D25EC-F248-11E8-B48F-1D18A9856A87","full_name":"Lagator, Mato"},{"orcid":"0000-0001-9435-2813","last_name":"Uecker","first_name":"Hildegard","id":"2DB8F68A-F248-11E8-B48F-1D18A9856A87","full_name":"Uecker, Hildegard"},{"first_name":"Paul","last_name":"Neve","full_name":"Neve, Paul"}],"date_published":"2021-05-12T00:00:00Z","volume":17,"abstract":[{"text":"Antibiotic concentrations vary dramatically in the body and the environment. Hence, understanding the dynamics of resistance evolution along antibiotic concentration gradients is critical for predicting and slowing the emergence and spread of resistance. While it has been shown that increasing the concentration of an antibiotic slows resistance evolution, how adaptation to one antibiotic concentration correlates with fitness at other points along the gradient has not received much attention. Here, we selected populations of Escherichia coli at several points along a concentration gradient for three different antibiotics, asking how rapidly resistance evolved and whether populations became specialized to the antibiotic concentration they were selected on. Populations selected at higher concentrations evolved resistance more slowly but exhibited equal or higher fitness across the whole gradient. Populations selected at lower concentrations evolved resistance rapidly, but overall fitness in the presence of antibiotics was lower. However, these populations readily adapted to higher concentrations upon subsequent selection. Our results indicate that resistance management strategies must account not only for the rates of resistance evolution but also for the fitness of evolved strains.","lang":"eng"}],"publication":"Biology letters","language":[{"iso":"eng"}],"year":"2021","day":"12","ec_funded":1,"pmid":1,"file":[{"relation":"main_file","checksum":"9c13c1f5af7609c97c741f11d293188a","date_created":"2021-05-25T14:09:03Z","creator":"kschuh","file_id":"9425","access_level":"open_access","file_size":726759,"file_name":"2021_BiologyLetters_Lagator.pdf","content_type":"application/pdf","date_updated":"2021-05-25T14:09:03Z","success":1}],"publisher":"Royal Society of London","scopus_import":"1","date_created":"2021-05-23T22:01:43Z","project":[{"_id":"25B07788-B435-11E9-9278-68D0E5697425","name":"Limits to selection in biology and in evolutionary computation","call_identifier":"FP7","grant_number":"250152"}],"has_accepted_license":"1","article_number":"20200913","oa_version":"Published Version","month":"05","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publication_status":"published","oa":1,"publication_identifier":{"eissn":["1744957X"]},"ddc":["570"],"date_updated":"2025-05-28T11:42:50Z","citation":{"ieee":"M. Lagator, H. Uecker, and P. Neve, “Adaptation at different points along antibiotic concentration gradients,” <i>Biology letters</i>, vol. 17, no. 5. Royal Society of London, 2021.","ista":"Lagator M, Uecker H, Neve P. 2021. Adaptation at different points along antibiotic concentration gradients. Biology letters. 17(5), 20200913.","mla":"Lagator, Mato, et al. “Adaptation at Different Points along Antibiotic Concentration Gradients.” <i>Biology Letters</i>, vol. 17, no. 5, 20200913, Royal Society of London, 2021, doi:<a href=\"https://doi.org/10.1098/rsbl.2020.0913\">10.1098/rsbl.2020.0913</a>.","apa":"Lagator, M., Uecker, H., &#38; Neve, P. (2021). Adaptation at different points along antibiotic concentration gradients. <i>Biology Letters</i>. Royal Society of London. <a href=\"https://doi.org/10.1098/rsbl.2020.0913\">https://doi.org/10.1098/rsbl.2020.0913</a>","chicago":"Lagator, Mato, Hildegard Uecker, and Paul Neve. “Adaptation at Different Points along Antibiotic Concentration Gradients.” <i>Biology Letters</i>. Royal Society of London, 2021. <a href=\"https://doi.org/10.1098/rsbl.2020.0913\">https://doi.org/10.1098/rsbl.2020.0913</a>.","short":"M. Lagator, H. Uecker, P. Neve, Biology Letters 17 (2021).","ama":"Lagator M, Uecker H, Neve P. Adaptation at different points along antibiotic concentration gradients. <i>Biology letters</i>. 2021;17(5). doi:<a href=\"https://doi.org/10.1098/rsbl.2020.0913\">10.1098/rsbl.2020.0913</a>"},"article_processing_charge":"No","isi":1,"title":"Adaptation at different points along antibiotic concentration gradients","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"type":"journal_article","status":"public","external_id":{"pmid":[" 33975485"],"isi":["000651501400001"]},"doi":"10.1098/rsbl.2020.0913","intvolume":"        17","_id":"9410","quality_controlled":"1","acknowledgement":"We would like to thank Martin Ackermann, Camilo Barbosa, Nick Barton, Jonathan Bollback, Sebastian Bonhoeffer, Nick Colegrave, Calin Guet, Alex Hall, Sally Otto, Tiago Paixao, Srdjan Sarikas, Hinrich Schulenburg, Marjon de Vos and Michael Whitlock for insightful support.","department":[{"_id":"NiBa"}]},{"day":"24","language":[{"iso":"eng"}],"year":"2021","publication":"European Physical Journal E","issue":"4","file_date_updated":"2021-05-25T11:32:14Z","abstract":[{"text":"The dynamics of a triangular magnetocapillary swimmer is studied using the lattice Boltzmann method. We extend on our previous work, which deals with the self-assembly and a specific type of the swimmer motion characterized by the swimmer’s maximum velocity centred around the particle’s inverse viscous time. Here, we identify additional regimes of motion. First, modifying the ratio of surface tension and magnetic forces allows to study the swimmer propagation in the regime of significantly lower frequencies mainly defined by the strength of the magnetocapillary potential. Second, introducing a constant magnetic contribution in each of the particles in addition to their magnetic moment induced by external fields leads to another regime characterized by strong in-plane swimmer reorientations that resemble experimental observations.","lang":"eng"}],"volume":44,"date_published":"2021-04-24T00:00:00Z","author":[{"full_name":"Sukhov, Alexander","last_name":"Sukhov","first_name":"Alexander"},{"last_name":"Hubert","first_name":"Maxime","full_name":"Hubert, Maxime"},{"orcid":"0000-0001-5154-417X","last_name":"Grosjean","first_name":"Galien M","id":"0C5FDA4A-9CF6-11E9-8939-FF05E6697425","full_name":"Grosjean, Galien M"},{"full_name":"Trosman, Oleg","first_name":"Oleg","last_name":"Trosman"},{"first_name":"Sebastian","last_name":"Ziegler","full_name":"Ziegler, Sebastian"},{"full_name":"Collard, Ylona","first_name":"Ylona","last_name":"Collard"},{"full_name":"Vandewalle, Nicolas","last_name":"Vandewalle","first_name":"Nicolas"},{"full_name":"Smith, Ana Sunčana","first_name":"Ana Sunčana","last_name":"Smith"},{"last_name":"Harting","first_name":"Jens","full_name":"Harting, Jens"}],"date_created":"2021-05-23T22:01:44Z","file":[{"success":1,"file_id":"9422","creator":"kschuh","date_created":"2021-05-25T11:32:14Z","checksum":"0ef342d011afbe3c5cb058fda9a3f395","relation":"main_file","date_updated":"2021-05-25T11:32:14Z","content_type":"application/pdf","file_name":"2021_EPJE_Sukhov.pdf","access_level":"open_access","file_size":2507870}],"publisher":"Springer","scopus_import":"1","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","oa_version":"Published Version","month":"04","ddc":["530"],"date_updated":"2023-08-08T13:36:28Z","publication_identifier":{"issn":["12928941"],"eissn":["1292895X"]},"publication_status":"published","oa":1,"has_accepted_license":"1","article_number":"59","_id":"9411","intvolume":"        44","doi":"10.1140/epje/s10189-021-00065-2","external_id":{"isi":["000643251300001"]},"department":[{"_id":"ScWa"}],"acknowledgement":"This work was financially supported by the DFG Priority Programme SPP 1726 “Microswimmers–From Single Particle Motion to Collective Behaviour” (HA 4382/5-1). We further acknowledge the Jülich Supercomputing Centre (JSC) and the High Performance Computing Centre Stuttgart (HLRS) for the allocation of computing time.","quality_controlled":"1","isi":1,"article_processing_charge":"No","citation":{"ista":"Sukhov A, Hubert M, Grosjean GM, Trosman O, Ziegler S, Collard Y, Vandewalle N, Smith AS, Harting J. 2021. Regimes of motion of magnetocapillary swimmers. European Physical Journal E. 44(4), 59.","ieee":"A. Sukhov <i>et al.</i>, “Regimes of motion of magnetocapillary swimmers,” <i>European Physical Journal E</i>, vol. 44, no. 4. Springer, 2021.","apa":"Sukhov, A., Hubert, M., Grosjean, G. M., Trosman, O., Ziegler, S., Collard, Y., … Harting, J. (2021). Regimes of motion of magnetocapillary swimmers. <i>European Physical Journal E</i>. Springer. <a href=\"https://doi.org/10.1140/epje/s10189-021-00065-2\">https://doi.org/10.1140/epje/s10189-021-00065-2</a>","mla":"Sukhov, Alexander, et al. “Regimes of Motion of Magnetocapillary Swimmers.” <i>European Physical Journal E</i>, vol. 44, no. 4, 59, Springer, 2021, doi:<a href=\"https://doi.org/10.1140/epje/s10189-021-00065-2\">10.1140/epje/s10189-021-00065-2</a>.","short":"A. Sukhov, M. Hubert, G.M. Grosjean, O. Trosman, S. Ziegler, Y. Collard, N. Vandewalle, A.S. Smith, J. Harting, European Physical Journal E 44 (2021).","chicago":"Sukhov, Alexander, Maxime Hubert, Galien M Grosjean, Oleg Trosman, Sebastian Ziegler, Ylona Collard, Nicolas Vandewalle, Ana Sunčana Smith, and Jens Harting. “Regimes of Motion of Magnetocapillary Swimmers.” <i>European Physical Journal E</i>. Springer, 2021. <a href=\"https://doi.org/10.1140/epje/s10189-021-00065-2\">https://doi.org/10.1140/epje/s10189-021-00065-2</a>.","ama":"Sukhov A, Hubert M, Grosjean GM, et al. Regimes of motion of magnetocapillary swimmers. <i>European Physical Journal E</i>. 2021;44(4). doi:<a href=\"https://doi.org/10.1140/epje/s10189-021-00065-2\">10.1140/epje/s10189-021-00065-2</a>"},"type":"journal_article","status":"public","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"title":"Regimes of motion of magnetocapillary swimmers"},{"type":"journal_article","status":"public","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"title":"Fluctuation around the circular law for random matrices with real entries","isi":1,"citation":{"ieee":"G. Cipolloni, L. Erdös, and D. J. Schröder, “Fluctuation around the circular law for random matrices with real entries,” <i>Electronic Journal of Probability</i>, vol. 26. Institute of Mathematical Statistics, 2021.","ista":"Cipolloni G, Erdös L, Schröder DJ. 2021. Fluctuation around the circular law for random matrices with real entries. Electronic Journal of Probability. 26, 24.","apa":"Cipolloni, G., Erdös, L., &#38; Schröder, D. J. (2021). Fluctuation around the circular law for random matrices with real entries. <i>Electronic Journal of Probability</i>. Institute of Mathematical Statistics. <a href=\"https://doi.org/10.1214/21-EJP591\">https://doi.org/10.1214/21-EJP591</a>","mla":"Cipolloni, Giorgio, et al. “Fluctuation around the Circular Law for Random Matrices with Real Entries.” <i>Electronic Journal of Probability</i>, vol. 26, 24, Institute of Mathematical Statistics, 2021, doi:<a href=\"https://doi.org/10.1214/21-EJP591\">10.1214/21-EJP591</a>.","ama":"Cipolloni G, Erdös L, Schröder DJ. Fluctuation around the circular law for random matrices with real entries. <i>Electronic Journal of Probability</i>. 2021;26. doi:<a href=\"https://doi.org/10.1214/21-EJP591\">10.1214/21-EJP591</a>","chicago":"Cipolloni, Giorgio, László Erdös, and Dominik J Schröder. “Fluctuation around the Circular Law for Random Matrices with Real Entries.” <i>Electronic Journal of Probability</i>. Institute of Mathematical Statistics, 2021. <a href=\"https://doi.org/10.1214/21-EJP591\">https://doi.org/10.1214/21-EJP591</a>.","short":"G. Cipolloni, L. Erdös, D.J. Schröder, Electronic Journal of Probability 26 (2021)."},"article_processing_charge":"No","department":[{"_id":"LaEr"}],"quality_controlled":"1","intvolume":"        26","_id":"9412","external_id":{"isi":["000641855600001"],"arxiv":["2002.02438"]},"doi":"10.1214/21-EJP591","article_number":"24","arxiv":1,"has_accepted_license":"1","publication_identifier":{"eissn":["10836489"]},"date_updated":"2023-08-08T13:39:19Z","ddc":["510"],"publication_status":"published","oa":1,"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","oa_version":"Published Version","month":"03","scopus_import":"1","publisher":"Institute of Mathematical Statistics","file":[{"checksum":"864ab003ad4cffea783f65aa8c2ba69f","relation":"main_file","date_created":"2021-05-25T13:24:19Z","creator":"kschuh","file_id":"9423","file_size":865148,"access_level":"open_access","file_name":"2021_EJP_Cipolloni.pdf","content_type":"application/pdf","date_updated":"2021-05-25T13:24:19Z","success":1}],"date_created":"2021-05-23T22:01:44Z","project":[{"grant_number":"665385","call_identifier":"H2020","name":"International IST Doctoral Program","_id":"2564DBCA-B435-11E9-9278-68D0E5697425"}],"date_published":"2021-03-23T00:00:00Z","volume":26,"abstract":[{"lang":"eng","text":"We extend our recent result [22] on the central limit theorem for the linear eigenvalue statistics of non-Hermitian matrices X with independent, identically distributed complex entries to the real symmetry class. We find that the expectation and variance substantially differ from their complex counterparts, reflecting (i) the special spectral symmetry of real matrices onto the real axis; and (ii) the fact that real i.i.d. matrices have many real eigenvalues. Our result generalizes the previously known special cases where either the test function is analytic [49] or the first four moments of the matrix elements match the real Gaussian [59, 44]. The key element of the proof is the analysis of several weakly dependent Dyson Brownian motions (DBMs). The conceptual novelty of the real case compared with [22] is that the correlation structure of the stochastic differentials in each individual DBM is non-trivial, potentially even jeopardising its well-posedness."}],"author":[{"id":"42198EFA-F248-11E8-B48F-1D18A9856A87","full_name":"Cipolloni, Giorgio","last_name":"Cipolloni","first_name":"Giorgio","orcid":"0000-0002-4901-7992"},{"orcid":"0000-0001-5366-9603","first_name":"László","last_name":"Erdös","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","full_name":"Erdös, László"},{"full_name":"Schröder, Dominik J","id":"408ED176-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2904-1856","first_name":"Dominik J","last_name":"Schröder"}],"file_date_updated":"2021-05-25T13:24:19Z","ec_funded":1,"language":[{"iso":"eng"}],"year":"2021","day":"23","publication":"Electronic Journal of Probability"},{"ec_funded":1,"day":"19","language":[{"iso":"eng"}],"year":"2021","publication":"Molecular Biology of the Cell","volume":32,"abstract":[{"text":"Microtubule plus-end depolymerization rate is a potentially important target of physiological regulation, but it has been challenging to measure, so its role in spatial organization is poorly understood. Here we apply a method for tracking plus ends based on time difference imaging to measure depolymerization rates in large interphase asters growing in Xenopus egg extract. We observed strong spatial regulation of depolymerization rates, which were higher in the aster interior compared with the periphery, and much less regulation of polymerization or catastrophe rates. We interpret these data in terms of a limiting component model, where aster growth results in lower levels of soluble tubulin and microtubule-associated proteins (MAPs) in the interior cytosol compared with that at the periphery. The steady-state polymer fraction of tubulin was ∼30%, so tubulin is not strongly depleted in the aster interior. We propose that the limiting component for microtubule assembly is a MAP that inhibits depolymerization, and that egg asters are tuned to low microtubule density.","lang":"eng"}],"date_published":"2021-04-19T00:00:00Z","author":[{"full_name":"Ishihara, Keisuke","last_name":"Ishihara","first_name":"Keisuke"},{"first_name":"Franziska","last_name":"Decker","full_name":"Decker, Franziska"},{"last_name":"Dos Santos Caldas","first_name":"Paulo R","orcid":"0000-0001-6730-4461","id":"38FCDB4C-F248-11E8-B48F-1D18A9856A87","full_name":"Dos Santos Caldas, Paulo R"},{"first_name":"James F.","last_name":"Pelletier","full_name":"Pelletier, James F."},{"last_name":"Loose","first_name":"Martin","orcid":"0000-0001-7309-9724","id":"462D4284-F248-11E8-B48F-1D18A9856A87","full_name":"Loose, Martin"},{"last_name":"Brugués","first_name":"Jan","full_name":"Brugués, Jan"},{"last_name":"Mitchison","first_name":"Timothy J.","full_name":"Mitchison, Timothy J."}],"issue":"9","project":[{"_id":"2595697A-B435-11E9-9278-68D0E5697425","name":"Self-Organization of the Bacterial Cell","call_identifier":"H2020","grant_number":"679239"},{"name":"Reconstitution of Bacterial Cell Division Using Purified Components","_id":"260D98C8-B435-11E9-9278-68D0E5697425"}],"date_created":"2021-05-23T22:01:45Z","article_type":"original","scopus_import":"1","publisher":"American Society for Cell Biology","main_file_link":[{"open_access":"1","url":"https://www.molbiolcell.org/doi/10.1091/mbc.E20-11-0723"}],"date_updated":"2023-08-08T13:36:02Z","publication_identifier":{"issn":["1059-1524"],"eissn":["1939-4586"]},"publication_status":"published","oa":1,"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","oa_version":"Published Version","month":"04","department":[{"_id":"MaLo"}],"acknowledgement":"The authors thank the members of Mitchison, Brugués, and Jay Gatlin groups (University of Wyoming) for discussions. We thank Heino Andreas (MPI-CBG) for frog maintenance. We thank Nikon for microscopy support at Marine Biological Laboratory (MBL). K.I. was supported by fellowships from the Honjo International Scholarship Foundation and Center of Systems Biology Dresden. F.D. was supported by the DIGGS-BB fellowship provided by the German Research Foundation (DFG). P.C. is supported by a Boehringer Ingelheim Fonds PhD fellowship. J.F.P. was supported by a fellowship from the Fannie and John Hertz Foundation. M.L.’s research is supported by European Research Council (ERC) Grant no. ERC-2015-StG-679239. J.B.’s research is supported by the Human Frontiers Science Program (CDA00074/2014). T.J.M.’s research is supported by National Institutes of Health Grant no. R35GM131753.","quality_controlled":"1","page":"869-879","license":"https://creativecommons.org/licenses/by-nc-sa/3.0/","_id":"9414","intvolume":"        32","doi":"10.1091/MBC.E20-11-0723","external_id":{"isi":["000641574700005"]},"status":"public","type":"journal_article","tmp":{"image":"/images/cc_by_nc_sa.png","short":"CC BY-NC-SA (3.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/3.0/legalcode","name":"Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)"},"title":"Spatial variation of microtubule depolymerization in large asters","isi":1,"citation":{"ama":"Ishihara K, Decker F, Dos Santos Caldas PR, et al. Spatial variation of microtubule depolymerization in large asters. <i>Molecular Biology of the Cell</i>. 2021;32(9):869-879. doi:<a href=\"https://doi.org/10.1091/MBC.E20-11-0723\">10.1091/MBC.E20-11-0723</a>","chicago":"Ishihara, Keisuke, Franziska Decker, Paulo R Dos Santos Caldas, James F. Pelletier, Martin Loose, Jan Brugués, and Timothy J. Mitchison. “Spatial Variation of Microtubule Depolymerization in Large Asters.” <i>Molecular Biology of the Cell</i>. American Society for Cell Biology, 2021. <a href=\"https://doi.org/10.1091/MBC.E20-11-0723\">https://doi.org/10.1091/MBC.E20-11-0723</a>.","short":"K. Ishihara, F. Decker, P.R. Dos Santos Caldas, J.F. Pelletier, M. Loose, J. Brugués, T.J. Mitchison, Molecular Biology of the Cell 32 (2021) 869–879.","mla":"Ishihara, Keisuke, et al. “Spatial Variation of Microtubule Depolymerization in Large Asters.” <i>Molecular Biology of the Cell</i>, vol. 32, no. 9, American Society for Cell Biology, 2021, pp. 869–79, doi:<a href=\"https://doi.org/10.1091/MBC.E20-11-0723\">10.1091/MBC.E20-11-0723</a>.","apa":"Ishihara, K., Decker, F., Dos Santos Caldas, P. R., Pelletier, J. F., Loose, M., Brugués, J., &#38; Mitchison, T. J. (2021). Spatial variation of microtubule depolymerization in large asters. <i>Molecular Biology of the Cell</i>. American Society for Cell Biology. <a href=\"https://doi.org/10.1091/MBC.E20-11-0723\">https://doi.org/10.1091/MBC.E20-11-0723</a>","ista":"Ishihara K, Decker F, Dos Santos Caldas PR, Pelletier JF, Loose M, Brugués J, Mitchison TJ. 2021. Spatial variation of microtubule depolymerization in large asters. Molecular Biology of the Cell. 32(9), 869–879.","ieee":"K. Ishihara <i>et al.</i>, “Spatial variation of microtubule depolymerization in large asters,” <i>Molecular Biology of the Cell</i>, vol. 32, no. 9. American Society for Cell Biology, pp. 869–879, 2021."},"article_processing_charge":"No"},{"file":[{"creator":"bphuong","date_created":"2021-05-24T11:15:57Z","relation":"main_file","checksum":"f34ff17017527db5ba6927f817bdd125","file_id":"9417","file_name":"iclr2021_conference.pdf","access_level":"open_access","file_size":502356,"date_updated":"2021-05-24T11:15:57Z","content_type":"application/pdf"}],"article_processing_charge":"No","main_file_link":[{"url":"https://openreview.net/pdf?id=krz7T0xU9Z_","open_access":"1"}],"citation":{"ista":"Phuong M, Lampert C. 2021. The inductive bias of ReLU networks on orthogonally separable data. 9th International Conference on Learning Representations.  ICLR: International Conference on Learning Representations.","ieee":"M. Phuong and C. Lampert, “The inductive bias of ReLU networks on orthogonally separable data,” in <i>9th International Conference on Learning Representations</i>, Virtual, 2021.","mla":"Phuong, Mary, and Christoph Lampert. “The Inductive Bias of ReLU Networks on Orthogonally Separable Data.” <i>9th International Conference on Learning Representations</i>, 2021.","apa":"Phuong, M., &#38; Lampert, C. (2021). The inductive bias of ReLU networks on orthogonally separable data. In <i>9th International Conference on Learning Representations</i>. Virtual.","chicago":"Phuong, Mary, and Christoph Lampert. “The Inductive Bias of ReLU Networks on Orthogonally Separable Data.” In <i>9th International Conference on Learning Representations</i>, 2021.","short":"M. Phuong, C. Lampert, in:, 9th International Conference on Learning Representations, 2021.","ama":"Phuong M, Lampert C. The inductive bias of ReLU networks on orthogonally separable data. In: <i>9th International Conference on Learning Representations</i>. ; 2021."},"status":"public","type":"conference","title":"The inductive bias of ReLU networks on orthogonally separable data","scopus_import":"1","_id":"9416","date_created":"2021-05-24T11:16:46Z","department":[{"_id":"GradSch"},{"_id":"ChLa"}],"quality_controlled":"1","has_accepted_license":"1","file_date_updated":"2021-05-24T11:15:57Z","abstract":[{"lang":"eng","text":"We study the inductive bias of two-layer ReLU networks trained by gradient flow. We identify a class of easy-to-learn (`orthogonally separable') datasets, and characterise the solution that ReLU networks trained on such datasets converge to. Irrespective of network width, the solution turns out to be a combination of two max-margin classifiers: one corresponding to the positive data subset and one corresponding to the negative data subset. The proof is based on the recently introduced concept of extremal sectors, for which we prove a number of properties in the context of orthogonal separability. In particular, we prove stationarity of activation patterns from some time  onwards, which enables a reduction of the ReLU network to an ensemble of linear subnetworks."}],"date_published":"2021-05-01T00:00:00Z","author":[{"id":"3EC6EE64-F248-11E8-B48F-1D18A9856A87","full_name":"Bui Thi Mai, Phuong","last_name":"Bui Thi Mai","first_name":"Phuong"},{"id":"40C20FD2-F248-11E8-B48F-1D18A9856A87","full_name":"Lampert, Christoph","orcid":"0000-0001-8622-7887","first_name":"Christoph","last_name":"Lampert"}],"day":"01","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"9418"}]},"language":[{"iso":"eng"}],"year":"2021","publication":"9th International Conference on Learning Representations","month":"05","oa_version":"Published Version","ddc":["000"],"date_updated":"2023-09-07T13:29:50Z","publication_status":"published","oa":1,"conference":{"end_date":"2021-05-07","name":" ICLR: International Conference on Learning Representations","start_date":"2021-05-03","location":"Virtual"}},{"abstract":[{"lang":"eng","text":"Deep learning is best known for its empirical success across a wide range of applications\r\nspanning computer vision, natural language processing and speech. Of equal significance,\r\nthough perhaps less known, are its ramifications for learning theory: deep networks have\r\nbeen observed to perform surprisingly well in the high-capacity regime, aka the overfitting\r\nor underspecified regime. Classically, this regime on the far right of the bias-variance curve\r\nis associated with poor generalisation; however, recent experiments with deep networks\r\nchallenge this view.\r\n\r\nThis thesis is devoted to investigating various aspects of underspecification in deep learning.\r\nFirst, we argue that deep learning models are underspecified on two levels: a) any given\r\ntraining dataset can be fit by many different functions, and b) any given function can be\r\nexpressed by many different parameter configurations. We refer to the second kind of\r\nunderspecification as parameterisation redundancy and we precisely characterise its extent.\r\nSecond, we characterise the implicit criteria (the inductive bias) that guide learning in the\r\nunderspecified regime. Specifically, we consider a nonlinear but tractable classification\r\nsetting, and show that given the choice, neural networks learn classifiers with a large margin.\r\nThird, we consider learning scenarios where the inductive bias is not by itself sufficient to\r\ndeal with underspecification. We then study different ways of ‘tightening the specification’: i)\r\nIn the setting of representation learning with variational autoencoders, we propose a hand-\r\ncrafted regulariser based on mutual information. ii) In the setting of binary classification, we\r\nconsider soft-label (real-valued) supervision. We derive a generalisation bound for linear\r\nnetworks supervised in this way and verify that soft labels facilitate fast learning. Finally, we\r\nexplore an application of soft-label supervision to the training of multi-exit models."}],"date_published":"2021-05-30T00:00:00Z","author":[{"full_name":"Bui Thi Mai, Phuong","id":"3EC6EE64-F248-11E8-B48F-1D18A9856A87","first_name":"Phuong","last_name":"Bui Thi Mai"}],"file_date_updated":"2021-05-24T11:56:02Z","day":"30","year":"2021","language":[{"iso":"eng"}],"supervisor":[{"full_name":"Lampert, Christoph","id":"40C20FD2-F248-11E8-B48F-1D18A9856A87","first_name":"Christoph","last_name":"Lampert","orcid":"0000-0001-8622-7887"}],"file":[{"file_id":"9419","date_created":"2021-05-24T11:22:29Z","creator":"bphuong","checksum":"4f0abe64114cfed264f9d36e8d1197e3","relation":"main_file","date_updated":"2021-05-24T11:22:29Z","content_type":"application/pdf","file_name":"mph-thesis-v519-pdfimages.pdf","file_size":2673905,"access_level":"open_access","success":1},{"content_type":"application/zip","date_updated":"2021-05-24T11:56:02Z","access_level":"closed","file_size":92995100,"file_name":"thesis.zip","file_id":"9420","relation":"source_file","checksum":"f5699e876bc770a9b0df8345a77720a2","date_created":"2021-05-24T11:56:02Z","creator":"bphuong"}],"publisher":"Institute of Science and Technology Austria","date_created":"2021-05-24T13:06:23Z","alternative_title":["ISTA Thesis"],"has_accepted_license":"1","date_updated":"2023-09-08T11:11:12Z","ddc":["000"],"publication_identifier":{"issn":["2663-337X"]},"publication_status":"published","oa":1,"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","related_material":{"record":[{"relation":"part_of_dissertation","id":"7435","status":"deleted"},{"id":"7481","relation":"part_of_dissertation","status":"public"},{"status":"public","id":"9416","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","id":"7479","status":"public"}]},"oa_version":"Published Version","month":"05","type":"dissertation","status":"public","title":"Underspecification in deep learning","acknowledged_ssus":[{"_id":"ScienComp"},{"_id":"CampIT"},{"_id":"E-Lib"}],"article_processing_charge":"No","citation":{"ista":"Phuong M. 2021. Underspecification in deep learning. Institute of Science and Technology Austria.","ieee":"M. Phuong, “Underspecification in deep learning,” Institute of Science and Technology Austria, 2021.","chicago":"Phuong, Mary. “Underspecification in Deep Learning.” Institute of Science and Technology Austria, 2021. <a href=\"https://doi.org/10.15479/AT:ISTA:9418\">https://doi.org/10.15479/AT:ISTA:9418</a>.","ama":"Phuong M. Underspecification in deep learning. 2021. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:9418\">10.15479/AT:ISTA:9418</a>","short":"M. Phuong, Underspecification in Deep Learning, Institute of Science and Technology Austria, 2021.","apa":"Phuong, M. (2021). <i>Underspecification in deep learning</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:9418\">https://doi.org/10.15479/AT:ISTA:9418</a>","mla":"Phuong, Mary. <i>Underspecification in Deep Learning</i>. Institute of Science and Technology Austria, 2021, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:9418\">10.15479/AT:ISTA:9418</a>."},"department":[{"_id":"GradSch"},{"_id":"ChLa"}],"degree_awarded":"PhD","_id":"9418","page":"125","doi":"10.15479/AT:ISTA:9418"},{"year":"2021","language":[{"iso":"eng"}],"day":"01","publication":"Nature Physics","ec_funded":1,"issue":"6","file_date_updated":"2021-12-02T23:30:03Z","date_published":"2021-06-01T00:00:00Z","abstract":[{"text":"Thermalization is the inevitable fate of many complex quantum systems, whose dynamics allow them to fully explore the vast configuration space regardless of the initial state---the behaviour known as quantum ergodicity. In a quest for experimental realizations of coherent long-time dynamics, efforts have focused on ergodicity-breaking mechanisms, such as integrability and localization. The recent discovery of persistent revivals in quantum simulators based on Rydberg atoms have pointed to the existence of a new type of behaviour where the system rapidly relaxes for most initial conditions, while certain initial states give rise to non-ergodic dynamics. This collective effect has been named ”quantum many-body scarring’by analogy with a related form of weak ergodicity breaking that occurs for a single particle inside a stadium billiard potential. In this Review, we provide a pedagogical introduction to quantum many-body scars and highlight the emerging connections with the semiclassical quantization of many-body systems. We discuss the relation between scars and more general routes towards weak violations of ergodicity due to embedded algebras and non-thermal eigenstates, and highlight possible applications of scars in quantum technology.","lang":"eng"}],"volume":17,"author":[{"full_name":"Serbyn, Maksym","id":"47809E7E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2399-5827","first_name":"Maksym","last_name":"Serbyn"},{"full_name":"Abanin, Dmitry A.","first_name":"Dmitry A.","last_name":"Abanin"},{"full_name":"Papić, Zlatko","last_name":"Papić","first_name":"Zlatko"}],"date_created":"2021-05-28T09:03:50Z","article_type":"review","project":[{"_id":"23841C26-32DE-11EA-91FC-C7463DDC885E","name":"Non-Ergodic Quantum Matter: Universality, Dynamics and Control","call_identifier":"H2020","grant_number":"850899"}],"file":[{"file_id":"10026","checksum":"316ed42ea1b42b0f1a3025bb476266fc","relation":"main_file","date_created":"2021-09-20T09:27:43Z","creator":"patrickd","content_type":"application/pdf","date_updated":"2021-12-02T23:30:03Z","access_level":"open_access","file_size":10028836,"file_name":"RevisedQMBSreview.pdf","embargo":"2021-12-01"}],"publisher":"Nature Research","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"Preprint","month":"06","publication_identifier":{"eissn":["1745-2481"]},"ddc":["539"],"date_updated":"2023-10-18T08:20:59Z","oa":1,"publication_status":"published","arxiv":1,"has_accepted_license":"1","intvolume":"        17","_id":"9428","page":"675–685","external_id":{"isi":["000655563800002"],"arxiv":["2011.09486"]},"doi":"10.1038/s41567-021-01230-2","department":[{"_id":"MaSe"}],"quality_controlled":"1","acknowledgement":"We thank our collaborators K. Bull, S. Choi, J.-Y. Desaules, W. W. Ho, A. Hudomal, M. Lukin, I. Martin, H. Pichler, N. Regnault, I. Vasić and in particular A. Michailidis and C. Turner, without whom this work would not have been possible. We also benefited from discussions with E. Altman, B. A. Bernevig, A. Chandran, P. Fendley, V. Khemani and L. Motrunich. M.S. was supported by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 850899). D.A.A. was supported by the Swiss National Science Foundation and by the ERC under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 864597). Z.P. acknowledges support by the Leverhulme Trust Research Leadership Award RL-2019-015.","isi":1,"article_processing_charge":"No","citation":{"apa":"Serbyn, M., Abanin, D. A., &#38; Papić, Z. (2021). Quantum many-body scars and weak breaking of ergodicity. <i>Nature Physics</i>. Nature Research. <a href=\"https://doi.org/10.1038/s41567-021-01230-2\">https://doi.org/10.1038/s41567-021-01230-2</a>","mla":"Serbyn, Maksym, et al. “Quantum Many-Body Scars and Weak Breaking of Ergodicity.” <i>Nature Physics</i>, vol. 17, no. 6, Nature Research, 2021, pp. 675–685, doi:<a href=\"https://doi.org/10.1038/s41567-021-01230-2\">10.1038/s41567-021-01230-2</a>.","ama":"Serbyn M, Abanin DA, Papić Z. Quantum many-body scars and weak breaking of ergodicity. <i>Nature Physics</i>. 2021;17(6):675–685. doi:<a href=\"https://doi.org/10.1038/s41567-021-01230-2\">10.1038/s41567-021-01230-2</a>","chicago":"Serbyn, Maksym, Dmitry A. Abanin, and Zlatko Papić. “Quantum Many-Body Scars and Weak Breaking of Ergodicity.” <i>Nature Physics</i>. Nature Research, 2021. <a href=\"https://doi.org/10.1038/s41567-021-01230-2\">https://doi.org/10.1038/s41567-021-01230-2</a>.","short":"M. Serbyn, D.A. Abanin, Z. Papić, Nature Physics 17 (2021) 675–685.","ista":"Serbyn M, Abanin DA, Papić Z. 2021. Quantum many-body scars and weak breaking of ergodicity. Nature Physics. 17(6), 675–685.","ieee":"M. Serbyn, D. A. Abanin, and Z. Papić, “Quantum many-body scars and weak breaking of ergodicity,” <i>Nature Physics</i>, vol. 17, no. 6. Nature Research, pp. 675–685, 2021."},"type":"journal_article","status":"public","title":"Quantum many-body scars and weak breaking of ergodicity"},{"file":[{"success":1,"file_id":"9430","checksum":"337e0f7959c35ec959984cacdcb472ba","relation":"main_file","creator":"kschuh","date_created":"2021-05-28T12:39:43Z","content_type":"application/pdf","date_updated":"2021-05-28T12:39:43Z","file_size":9358599,"access_level":"open_access","file_name":"2021_NatureCommunications_Morandell.pdf"}],"publisher":"Springer Nature","article_type":"original","project":[{"grant_number":"754411","call_identifier":"H2020","name":"ISTplus - Postdoctoral Fellowships","_id":"260C2330-B435-11E9-9278-68D0E5697425"},{"name":"Probing the Reversibility of Autism Spectrum Disorders by Employing in vivo and in vitro Models","_id":"25444568-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"715508"},{"grant_number":"W1232-B24","call_identifier":"FWF","name":"Molecular Drug Targets","_id":"2548AE96-B435-11E9-9278-68D0E5697425"},{"_id":"05A0D778-7A3F-11EA-A408-12923DDC885E","name":"Neural stem cells in autism and epilepsy","grant_number":"F07807"},{"name":"Optical control of synaptic function via adhesion molecules","_id":"265CB4D0-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","grant_number":"I03600"}],"date_created":"2021-05-28T11:49:46Z","author":[{"last_name":"Morandell","first_name":"Jasmin","id":"4739D480-F248-11E8-B48F-1D18A9856A87","full_name":"Morandell, Jasmin"},{"full_name":"Schwarz, Lena A","id":"29A8453C-F248-11E8-B48F-1D18A9856A87","first_name":"Lena A","last_name":"Schwarz"},{"last_name":"Basilico","first_name":"Bernadette","orcid":"0000-0003-1843-3173","full_name":"Basilico, Bernadette","id":"36035796-5ACA-11E9-A75E-7AF2E5697425"},{"full_name":"Tasciyan, Saren","id":"4323B49C-F248-11E8-B48F-1D18A9856A87","first_name":"Saren","last_name":"Tasciyan","orcid":"0000-0003-1671-393X"},{"id":"38C393BE-F248-11E8-B48F-1D18A9856A87","full_name":"Dimchev, Georgi A","orcid":"0000-0001-8370-6161","last_name":"Dimchev","first_name":"Georgi A"},{"id":"2A103192-F248-11E8-B48F-1D18A9856A87","full_name":"Nicolas, Armel","first_name":"Armel","last_name":"Nicolas"},{"last_name":"Sommer","first_name":"Christoph M","orcid":"0000-0003-1216-9105","full_name":"Sommer, Christoph M","id":"4DF26D8C-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Kreuzinger, Caroline","id":"382077BA-F248-11E8-B48F-1D18A9856A87","first_name":"Caroline","last_name":"Kreuzinger"},{"id":"4C66542E-F248-11E8-B48F-1D18A9856A87","full_name":"Dotter, Christoph","first_name":"Christoph","last_name":"Dotter","orcid":"0000-0002-9033-9096"},{"first_name":"Lisa","last_name":"Knaus","id":"3B2ABCF4-F248-11E8-B48F-1D18A9856A87","full_name":"Knaus, Lisa"},{"full_name":"Dobler, Zoe","id":"D23090A2-9057-11EA-883A-A8396FC7A38F","last_name":"Dobler","first_name":"Zoe"},{"last_name":"Cacci","first_name":"Emanuele","full_name":"Cacci, Emanuele"},{"full_name":"Schur, Florian KM","id":"48AD8942-F248-11E8-B48F-1D18A9856A87","last_name":"Schur","first_name":"Florian KM","orcid":"0000-0003-4790-8078"},{"last_name":"Danzl","first_name":"Johann G","orcid":"0000-0001-8559-3973","id":"42EFD3B6-F248-11E8-B48F-1D18A9856A87","full_name":"Danzl, Johann G"},{"full_name":"Novarino, Gaia","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-7673-7178","last_name":"Novarino","first_name":"Gaia"}],"abstract":[{"text":"De novo loss of function mutations in the ubiquitin ligase-encoding gene Cullin3 lead to autism spectrum disorder (ASD). In mouse, constitutive haploinsufficiency leads to motor coordination deficits as well as ASD-relevant social and cognitive impairments. However, induction of Cul3 haploinsufficiency later in life does not lead to ASD-relevant behaviors, pointing to an important role of Cul3 during a critical developmental window. Here we show that Cul3 is essential to regulate neuronal migration and, therefore, constitutive Cul3 heterozygous mutant mice display cortical lamination abnormalities. At the molecular level, we found that Cul3 controls neuronal migration by tightly regulating the amount of Plastin3 (Pls3), a previously unrecognized player of neural migration. Furthermore, we found that Pls3 cell-autonomously regulates cell migration by regulating actin cytoskeleton organization, and its levels are inversely proportional to neural migration speed. Finally, we provide evidence that cellular phenotypes associated with autism-linked gene haploinsufficiency can be rescued by transcriptional activation of the intact allele in vitro, offering a proof of concept for a potential therapeutic approach for ASDs.","lang":"eng"}],"volume":12,"date_published":"2021-05-24T00:00:00Z","file_date_updated":"2021-05-28T12:39:43Z","issue":"1","keyword":["General Biochemistry","Genetics and Molecular Biology"],"ec_funded":1,"publication":"Nature Communications","day":"24","year":"2021","language":[{"iso":"eng"}],"title":"Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"type":"journal_article","status":"public","article_processing_charge":"No","citation":{"ista":"Morandell J, Schwarz LA, Basilico B, Tasciyan S, Dimchev GA, Nicolas A, Sommer CM, Kreuzinger C, Dotter C, Knaus L, Dobler Z, Cacci E, Schur FK, Danzl JG, Novarino G. 2021. Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development. Nature Communications. 12(1), 3058.","ieee":"J. Morandell <i>et al.</i>, “Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development,” <i>Nature Communications</i>, vol. 12, no. 1. Springer Nature, 2021.","short":"J. Morandell, L.A. Schwarz, B. Basilico, S. Tasciyan, G.A. Dimchev, A. Nicolas, C.M. Sommer, C. Kreuzinger, C. Dotter, L. Knaus, Z. Dobler, E. Cacci, F.K. Schur, J.G. Danzl, G. Novarino, Nature Communications 12 (2021).","chicago":"Morandell, Jasmin, Lena A Schwarz, Bernadette Basilico, Saren Tasciyan, Georgi A Dimchev, Armel Nicolas, Christoph M Sommer, et al. “Cul3 Regulates Cytoskeleton Protein Homeostasis and Cell Migration during a Critical Window of Brain Development.” <i>Nature Communications</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s41467-021-23123-x\">https://doi.org/10.1038/s41467-021-23123-x</a>.","ama":"Morandell J, Schwarz LA, Basilico B, et al. Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development. <i>Nature Communications</i>. 2021;12(1). doi:<a href=\"https://doi.org/10.1038/s41467-021-23123-x\">10.1038/s41467-021-23123-x</a>","apa":"Morandell, J., Schwarz, L. A., Basilico, B., Tasciyan, S., Dimchev, G. A., Nicolas, A., … Novarino, G. (2021). Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-021-23123-x\">https://doi.org/10.1038/s41467-021-23123-x</a>","mla":"Morandell, Jasmin, et al. “Cul3 Regulates Cytoskeleton Protein Homeostasis and Cell Migration during a Critical Window of Brain Development.” <i>Nature Communications</i>, vol. 12, no. 1, 3058, Springer Nature, 2021, doi:<a href=\"https://doi.org/10.1038/s41467-021-23123-x\">10.1038/s41467-021-23123-x</a>."},"isi":1,"acknowledged_ssus":[{"_id":"PreCl"}],"acknowledgement":"We thank A. Coll Manzano, F. Freeman, M. Ladron de Guevara, and A. Ç. Yahya for technical assistance, S. Deixler, A. Lepold, and A. Schlerka for the management of our animal colony, as well as M. Schunn and the Preclinical Facility team for technical assistance. We thank K. Heesom and her team at the University of Bristol Proteomics Facility for the proteomics sample preparation, data generation, and analysis support. We thank Y. B. Simon for kindly providing the plasmid for lentiviral labeling. Further, we thank M. Sixt for his advice regarding cell migration and the fruitful discussions. This work was supported by the ISTPlus postdoctoral fellowship (Grant Agreement No. 754411) to B.B., by the European Union’s Horizon 2020 research and innovation program (ERC) grant 715508 (REVERSEAUTISM), and by the Austrian Science Fund (FWF) to G.N. (DK W1232-B24 and SFB F7807-B) and to J.G.D (I3600-B27).","quality_controlled":"1","department":[{"_id":"GaNo"},{"_id":"JoDa"},{"_id":"FlSc"},{"_id":"MiSi"},{"_id":"LifeSc"},{"_id":"Bio"}],"doi":"10.1038/s41467-021-23123-x","external_id":{"isi":["000658769900010"]},"_id":"9429","intvolume":"        12","article_number":"3058","has_accepted_license":"1","publication_status":"published","oa":1,"date_updated":"2024-09-10T12:04:26Z","ddc":["572"],"publication_identifier":{"eissn":["2041-1723"]},"oa_version":"Published Version","month":"05","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","related_material":{"record":[{"status":"public","relation":"earlier_version","id":"7800"},{"id":"12401","relation":"dissertation_contains","status":"public"}],"link":[{"relation":"press_release","url":"https://ist.ac.at/en/news/defective-gene-slows-down-brain-cells/"}]}},{"acknowledgement":"This work was funded by the National Institute of Allergy and Infectious Diseases under awards R01AI147890 to R.A.D., R01AI150454 to V.M.V, R35GM136258 in support of J-P.R.F, and the Austrian Science Fund (FWF) grant P31445 to F.K.M.S. Access to high-resolution cryo-ET data acquisition at EMBL Heidelberg was supported by iNEXT (grant no. 653706), funded by the Horizon 2020 program of the European Union (PID 4246). We thank Wim Hagen and Felix Weis at EMBL Heidelberg for support in cryo-ET data acquisition. This work made use of the Cornell Center for Materials Research Shared Facilities, which are supported through the NSF MRSEC program (DMR-179875). This research was also supported by the Scientific Service Units (SSUs) of IST Austria through resources provided by Scientific Computing (SciComp), the Life Science Facility (LSF), and the Electron Microscopy Facility (EMF).","quality_controlled":"1","department":[{"_id":"FlSc"}],"doi":"10.1038/s41467-021-23506-0","external_id":{"isi":["000659145000011"]},"_id":"9431","intvolume":"        12","title":"Structure of the mature Rous sarcoma virus lattice reveals a role for IP6 in the formation of the capsid hexamer","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"type":"journal_article","status":"public","article_processing_charge":"No","citation":{"ieee":"M. Obr <i>et al.</i>, “Structure of the mature Rous sarcoma virus lattice reveals a role for IP6 in the formation of the capsid hexamer,” <i>Nature Communications</i>, vol. 12, no. 1. Nature Research, 2021.","ista":"Obr M, Ricana CL, Nikulin N, Feathers J-PR, Klanschnig M, Thader A, Johnson MC, Vogt VM, Schur FK, Dick RA. 2021. Structure of the mature Rous sarcoma virus lattice reveals a role for IP6 in the formation of the capsid hexamer. Nature Communications. 12(1), 3226.","short":"M. Obr, C.L. Ricana, N. Nikulin, J.-P.R. Feathers, M. Klanschnig, A. Thader, M.C. Johnson, V.M. Vogt, F.K. Schur, R.A. Dick, Nature Communications 12 (2021).","ama":"Obr M, Ricana CL, Nikulin N, et al. Structure of the mature Rous sarcoma virus lattice reveals a role for IP6 in the formation of the capsid hexamer. <i>Nature Communications</i>. 2021;12(1). doi:<a href=\"https://doi.org/10.1038/s41467-021-23506-0\">10.1038/s41467-021-23506-0</a>","chicago":"Obr, Martin, Clifton L. Ricana, Nadia Nikulin, Jon-Philip R. Feathers, Marco Klanschnig, Andreas Thader, Marc C. Johnson, Volker M. Vogt, Florian KM Schur, and Robert A. Dick. “Structure of the Mature Rous Sarcoma Virus Lattice Reveals a Role for IP6 in the Formation of the Capsid Hexamer.” <i>Nature Communications</i>. Nature Research, 2021. <a href=\"https://doi.org/10.1038/s41467-021-23506-0\">https://doi.org/10.1038/s41467-021-23506-0</a>.","mla":"Obr, Martin, et al. “Structure of the Mature Rous Sarcoma Virus Lattice Reveals a Role for IP6 in the Formation of the Capsid Hexamer.” <i>Nature Communications</i>, vol. 12, no. 1, 3226, Nature Research, 2021, doi:<a href=\"https://doi.org/10.1038/s41467-021-23506-0\">10.1038/s41467-021-23506-0</a>.","apa":"Obr, M., Ricana, C. L., Nikulin, N., Feathers, J.-P. R., Klanschnig, M., Thader, A., … Dick, R. A. (2021). Structure of the mature Rous sarcoma virus lattice reveals a role for IP6 in the formation of the capsid hexamer. <i>Nature Communications</i>. Nature Research. <a href=\"https://doi.org/10.1038/s41467-021-23506-0\">https://doi.org/10.1038/s41467-021-23506-0</a>"},"isi":1,"acknowledged_ssus":[{"_id":"ScienComp"},{"_id":"LifeSc"},{"_id":"EM-Fac"}],"oa":1,"publication_status":"published","ddc":["570"],"date_updated":"2023-08-08T13:53:53Z","publication_identifier":{"eissn":["2041-1723"]},"oa_version":"Published Version","month":"05","related_material":{"link":[{"description":"News on IST Homepage","relation":"press_release","url":"https://ist.ac.at/en/news/how-retroviruses-become-infectious/"}]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","article_number":"3226","has_accepted_license":"1","project":[{"call_identifier":"FWF","grant_number":"P31445","name":"Structural conservation and diversity in retroviral capsid","_id":"26736D6A-B435-11E9-9278-68D0E5697425"}],"article_type":"original","date_created":"2021-05-28T14:25:50Z","scopus_import":"1","publisher":"Nature Research","file":[{"success":1,"file_name":"2021_NatureCommunications_Obr.pdf","access_level":"open_access","file_size":6166295,"date_updated":"2021-06-09T15:21:14Z","content_type":"application/pdf","date_created":"2021-06-09T15:21:14Z","creator":"kschuh","relation":"main_file","checksum":"53ccc53d09a9111143839dbe7784e663","file_id":"9538"}],"keyword":["General Biochemistry","Genetics and Molecular Biology","General Physics and Astronomy","General Chemistry"],"publication":"Nature Communications","day":"28","language":[{"iso":"eng"}],"year":"2021","author":[{"last_name":"Obr","first_name":"Martin","full_name":"Obr, Martin","id":"4741CA5A-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Ricana","first_name":"Clifton L.","full_name":"Ricana, Clifton L."},{"full_name":"Nikulin, Nadia","last_name":"Nikulin","first_name":"Nadia"},{"last_name":"Feathers","first_name":"Jon-Philip R.","full_name":"Feathers, Jon-Philip R."},{"last_name":"Klanschnig","first_name":"Marco","full_name":"Klanschnig, Marco"},{"id":"3A18A7B8-F248-11E8-B48F-1D18A9856A87","full_name":"Thader, Andreas","last_name":"Thader","first_name":"Andreas"},{"full_name":"Johnson, Marc C.","first_name":"Marc C.","last_name":"Johnson"},{"first_name":"Volker M.","last_name":"Vogt","full_name":"Vogt, Volker M."},{"full_name":"Schur, Florian KM","id":"48AD8942-F248-11E8-B48F-1D18A9856A87","first_name":"Florian KM","last_name":"Schur","orcid":"0000-0003-4790-8078"},{"last_name":"Dick","first_name":"Robert A.","full_name":"Dick, Robert A."}],"volume":12,"abstract":[{"text":"Inositol hexakisphosphate (IP6) is an assembly cofactor for HIV-1. We report here that IP6 is also used for assembly of Rous sarcoma virus (RSV), a retrovirus from a different genus. IP6 is ~100-fold more potent at promoting RSV mature capsid protein (CA) assembly than observed for HIV-1 and removal of IP6 in cells reduces infectivity by 100-fold. Here, visualized by cryo-electron tomography and subtomogram averaging, mature capsid-like particles show an IP6-like density in the CA hexamer, coordinated by rings of six lysines and six arginines. Phosphate and IP6 have opposing effects on CA in vitro assembly, inducing formation of T = 1 icosahedrons and tubes, respectively, implying that phosphate promotes pentamer and IP6 hexamer formation. Subtomogram averaging and classification optimized for analysis of pleomorphic retrovirus particles reveal that the heterogeneity of mature RSV CA polyhedrons results from an unexpected, intrinsic CA hexamer flexibility. In contrast, the CA pentamer forms rigid units organizing the local architecture. These different features of hexamers and pentamers determine the structural mechanism to form CA polyhedrons of variable shape in mature RSV particles.","lang":"eng"}],"date_published":"2021-05-28T00:00:00Z","file_date_updated":"2021-06-09T15:21:14Z","issue":"1"},{"abstract":[{"text":"For any given positive integer l, we prove that every plane deformation of a circlewhich preserves the 1/2and 1/ (2l + 1) -rational caustics is trivial i.e. the deformationconsists only of similarities (rescalings and isometries).","lang":"eng"}],"date_published":"2021-01-01T00:00:00Z","author":[{"last_name":"Kaloshin","first_name":"Vadim","orcid":"0000-0002-6051-2628","full_name":"Kaloshin, Vadim","id":"FE553552-CDE8-11E9-B324-C0EBE5697425"},{"full_name":"Koudjinan, Edmond","id":"52DF3E68-AEFA-11EA-95A4-124A3DDC885E","first_name":"Edmond","last_name":"Koudjinan","orcid":"0000-0003-2640-4049"}],"has_accepted_license":"1","file_date_updated":"2021-05-30T13:57:37Z","date_updated":"2021-06-01T09:10:22Z","ddc":["500"],"oa":1,"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","language":[{"iso":"eng"}],"year":"2021","oa_version":"Submitted Version","type":"preprint","status":"public","title":"Non co-preservation of the 1/2 and  1/(2l+1)-rational caustics along deformations of circles","file":[{"file_name":"CoExistence 2&3 caustics 3_17_6_2_3.pdf","file_size":353431,"access_level":"open_access","date_updated":"2021-05-30T13:57:37Z","content_type":"application/pdf","date_created":"2021-05-30T13:57:37Z","creator":"ekoudjin","checksum":"b281b5c2e3e90de0646c3eafcb2c6c25","relation":"main_file","file_id":"9436"}],"citation":{"ista":"Kaloshin V, Koudjinan E. 2021. Non co-preservation of the 1/2 and  1/(2l+1)-rational caustics along deformations of circles.","ieee":"V. Kaloshin and E. Koudjinan, “Non co-preservation of the 1/2 and  1/(2l+1)-rational caustics along deformations of circles.” 2021.","short":"V. Kaloshin, E. Koudjinan, (2021).","chicago":"Kaloshin, Vadim, and Edmond Koudjinan. “Non Co-Preservation of the 1/2 and  1/(2l+1)-Rational Caustics along Deformations of Circles,” 2021.","ama":"Kaloshin V, Koudjinan E. Non co-preservation of the 1/2 and  1/(2l+1)-rational caustics along deformations of circles. 2021.","mla":"Kaloshin, Vadim, and Edmond Koudjinan. <i>Non Co-Preservation of the 1/2 and  1/(2l+1)-Rational Caustics along Deformations of Circles</i>. 2021.","apa":"Kaloshin, V., &#38; Koudjinan, E. (2021). Non co-preservation of the 1/2 and  1/(2l+1)-rational caustics along deformations of circles."},"article_processing_charge":"No","department":[{"_id":"VaKa"}],"_id":"9435","date_created":"2021-05-30T13:58:13Z"},{"type":"journal_article","status":"public","title":"GABAB receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"isi":1,"citation":{"chicago":"Bhandari, Pradeep, David H Vandael, Diego Fernández-Fernández, Thorsten Fritzius, David Kleindienst, Hüseyin C Önal, Jacqueline-Claire Montanaro-Punzengruber, et al. “GABAB Receptor Auxiliary Subunits Modulate Cav2.3-Mediated Release from Medial Habenula Terminals.” <i>ELife</i>. eLife Sciences Publications, 2021. <a href=\"https://doi.org/10.7554/ELIFE.68274\">https://doi.org/10.7554/ELIFE.68274</a>.","short":"P. Bhandari, D.H. Vandael, D. Fernández-Fernández, T. Fritzius, D. Kleindienst, H.C. Önal, J.-C. Montanaro-Punzengruber, M. Gassmann, P.M. Jonas, A. Kulik, B. Bettler, R. Shigemoto, P. Koppensteiner, ELife 10 (2021).","ama":"Bhandari P, Vandael DH, Fernández-Fernández D, et al. GABAB receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals. <i>eLife</i>. 2021;10. doi:<a href=\"https://doi.org/10.7554/ELIFE.68274\">10.7554/ELIFE.68274</a>","apa":"Bhandari, P., Vandael, D. H., Fernández-Fernández, D., Fritzius, T., Kleindienst, D., Önal, H. C., … Koppensteiner, P. (2021). GABAB receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals. <i>ELife</i>. eLife Sciences Publications. <a href=\"https://doi.org/10.7554/ELIFE.68274\">https://doi.org/10.7554/ELIFE.68274</a>","mla":"Bhandari, Pradeep, et al. “GABAB Receptor Auxiliary Subunits Modulate Cav2.3-Mediated Release from Medial Habenula Terminals.” <i>ELife</i>, vol. 10, e68274, eLife Sciences Publications, 2021, doi:<a href=\"https://doi.org/10.7554/ELIFE.68274\">10.7554/ELIFE.68274</a>.","ista":"Bhandari P, Vandael DH, Fernández-Fernández D, Fritzius T, Kleindienst D, Önal HC, Montanaro-Punzengruber J-C, Gassmann M, Jonas PM, Kulik A, Bettler B, Shigemoto R, Koppensteiner P. 2021. GABAB receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals. eLife. 10, e68274.","ieee":"P. Bhandari <i>et al.</i>, “GABAB receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals,” <i>eLife</i>, vol. 10. eLife Sciences Publications, 2021."},"article_processing_charge":"No","department":[{"_id":"RySh"},{"_id":"PeJo"}],"quality_controlled":"1","acknowledgement":"We are grateful to Akari Hagiwara and Toshihisa Ohtsuka for CAST antibody, and Masahiko Watanabe for neurexin antibody. We thank David Adams for kindly providing the stable Cav2.3 cell line. Cav2.3 KO mice were kindly provided by Tsutomu Tanabe. This project has received funding from the European Research Council (ERC) and European Commission (EC), under the European Union’s Horizon 2020 research and innovation programme (ERC grant agreement no. 694539 to Ryuichi Shigemoto, no. 692692 to Peter Jonas, and the Marie Skłodowska-Curie grant agreement no. 665385 to Cihan Önal), the Swiss National Science Foundation Grant 31003A-172881 to Bernhard Bettler and Deutsche Forschungsgemeinschaft (For 2143) and BIOSS-2 to Akos Kulik.","intvolume":"        10","_id":"9437","external_id":{"isi":["000651761700001"]},"doi":"10.7554/ELIFE.68274","article_number":"e68274","has_accepted_license":"1","publication_identifier":{"eissn":["2050-084X"]},"ddc":["570"],"date_updated":"2024-03-25T23:30:16Z","publication_status":"published","oa":1,"related_material":{"record":[{"status":"public","id":"9562","relation":"dissertation_contains"}],"link":[{"url":"https://doi.org/10.1101/2020.04.16.045112","relation":"earlier_version"}]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","month":"04","oa_version":"Published Version","scopus_import":"1","publisher":"eLife Sciences Publications","file":[{"success":1,"date_updated":"2021-05-31T09:43:09Z","content_type":"application/pdf","file_name":"2021_eLife_Bhandari.pdf","file_size":8174719,"access_level":"open_access","file_id":"9440","creator":"cziletti","date_created":"2021-05-31T09:43:09Z","checksum":"6ebcb79999f889766f7cd79ee134ad28","relation":"main_file"}],"project":[{"call_identifier":"H2020","grant_number":"694539","name":"In situ analysis of single channel subunit composition in neurons: physiological implication in synaptic plasticity and behaviour","_id":"25CA28EA-B435-11E9-9278-68D0E5697425"},{"_id":"25B7EB9E-B435-11E9-9278-68D0E5697425","name":"Biophysics and circuit function of a giant cortical glumatergic synapse","grant_number":"692692","call_identifier":"H2020"},{"grant_number":"665385","call_identifier":"H2020","name":"International IST Doctoral Program","_id":"2564DBCA-B435-11E9-9278-68D0E5697425"}],"article_type":"original","date_created":"2021-05-30T22:01:23Z","date_published":"2021-04-29T00:00:00Z","abstract":[{"text":"The synaptic connection from medial habenula (MHb) to interpeduncular nucleus (IPN) is critical for emotion-related behaviors and uniquely expresses R-type Ca2+ channels (Cav2.3) and auxiliary GABAB receptor (GBR) subunits, the K+-channel tetramerization domain-containing proteins (KCTDs). Activation of GBRs facilitates or inhibits transmitter release from MHb terminals depending on the IPN subnucleus, but the role of KCTDs is unknown. We therefore examined the localization and function of Cav2.3, GBRs, and KCTDs in this pathway in mice. We show in heterologous cells that KCTD8 and KCTD12b directly bind to Cav2.3 and that KCTD8 potentiates Cav2.3 currents in the absence of GBRs. In the rostral IPN, KCTD8, KCTD12b, and Cav2.3 co-localize at the presynaptic active zone. Genetic deletion indicated a bidirectional modulation of Cav2.3-mediated release by these KCTDs with a compensatory increase of KCTD8 in the active zone in KCTD12b-deficient mice. The interaction of Cav2.3 with KCTDs therefore scales synaptic strength independent of GBR activation.","lang":"eng"}],"volume":10,"author":[{"last_name":"Bhandari","first_name":"Pradeep","orcid":"0000-0003-0863-4481","id":"45EDD1BC-F248-11E8-B48F-1D18A9856A87","full_name":"Bhandari, Pradeep"},{"full_name":"Vandael, David H","id":"3AE48E0A-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-7577-1676","last_name":"Vandael","first_name":"David H"},{"full_name":"Fernández-Fernández, Diego","first_name":"Diego","last_name":"Fernández-Fernández"},{"last_name":"Fritzius","first_name":"Thorsten","full_name":"Fritzius, Thorsten"},{"first_name":"David","last_name":"Kleindienst","full_name":"Kleindienst, David","id":"42E121A4-F248-11E8-B48F-1D18A9856A87"},{"id":"4659D740-F248-11E8-B48F-1D18A9856A87","full_name":"Önal, Hüseyin C","orcid":"0000-0002-2771-2011","last_name":"Önal","first_name":"Hüseyin C"},{"id":"3786AB44-F248-11E8-B48F-1D18A9856A87","full_name":"Montanaro-Punzengruber, Jacqueline-Claire","last_name":"Montanaro-Punzengruber","first_name":"Jacqueline-Claire"},{"full_name":"Gassmann, Martin","first_name":"Martin","last_name":"Gassmann"},{"id":"353C1B58-F248-11E8-B48F-1D18A9856A87","full_name":"Jonas, Peter M","last_name":"Jonas","first_name":"Peter M","orcid":"0000-0001-5001-4804"},{"first_name":"Akos","last_name":"Kulik","full_name":"Kulik, Akos"},{"full_name":"Bettler, Bernhard","first_name":"Bernhard","last_name":"Bettler"},{"full_name":"Shigemoto, Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","first_name":"Ryuichi","last_name":"Shigemoto"},{"orcid":"0000-0002-3509-1948","first_name":"Peter","last_name":"Koppensteiner","id":"3B8B25A8-F248-11E8-B48F-1D18A9856A87","full_name":"Koppensteiner, Peter"}],"file_date_updated":"2021-05-31T09:43:09Z","ec_funded":1,"year":"2021","language":[{"iso":"eng"}],"day":"29","publication":"eLife"},{"ddc":["570"],"date_updated":"2023-08-10T22:30:51Z","publication_identifier":{"issn":["17542189"],"eissn":["17502799"]},"oa":1,"publication_status":"published","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","oa_version":"Submitted Version","month":"06","has_accepted_license":"1","department":[{"_id":"PeJo"}],"acknowledgement":"This project received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 692692 to P.J.) and the Fond zur Förderung der Wissenschaftlichen Forschung (Z 312-B27, Wittgenstein award to P.J., V 739-B27 to C.B.M.). We are grateful to F. Marr and C. Altmutter for excellent technical assistance and cell reconstruction, E. Kralli-Beller for manuscript editing, and the Scientific Service Units of IST Austria, especially T. Asenov and Miba machine shop, for maximally efficient support.","quality_controlled":"1","page":"2947–2967","_id":"9438","intvolume":"        16","doi":"10.1038/s41596-021-00526-0","external_id":{"pmid":["33990799"],"isi":["000650528700003"]},"type":"journal_article","status":"public","title":"Subcellular patch-clamp techniques for single-bouton stimulation and simultaneous pre- and postsynaptic recording at cortical synapses","isi":1,"acknowledged_ssus":[{"_id":"M-Shop"}],"article_processing_charge":"No","citation":{"ista":"Vandael DH, Okamoto Y, Borges Merjane C, Vargas Barroso VM, Suter B, Jonas PM. 2021. Subcellular patch-clamp techniques for single-bouton stimulation and simultaneous pre- and postsynaptic recording at cortical synapses. Nature Protocols. 16(6), 2947–2967.","ieee":"D. H. Vandael, Y. Okamoto, C. Borges Merjane, V. M. Vargas Barroso, B. Suter, and P. M. Jonas, “Subcellular patch-clamp techniques for single-bouton stimulation and simultaneous pre- and postsynaptic recording at cortical synapses,” <i>Nature Protocols</i>, vol. 16, no. 6. Springer Nature, pp. 2947–2967, 2021.","apa":"Vandael, D. H., Okamoto, Y., Borges Merjane, C., Vargas Barroso, V. M., Suter, B., &#38; Jonas, P. M. (2021). Subcellular patch-clamp techniques for single-bouton stimulation and simultaneous pre- and postsynaptic recording at cortical synapses. <i>Nature Protocols</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41596-021-00526-0\">https://doi.org/10.1038/s41596-021-00526-0</a>","mla":"Vandael, David H., et al. “Subcellular Patch-Clamp Techniques for Single-Bouton Stimulation and Simultaneous Pre- and Postsynaptic Recording at Cortical Synapses.” <i>Nature Protocols</i>, vol. 16, no. 6, Springer Nature, 2021, pp. 2947–2967, doi:<a href=\"https://doi.org/10.1038/s41596-021-00526-0\">10.1038/s41596-021-00526-0</a>.","ama":"Vandael DH, Okamoto Y, Borges Merjane C, Vargas Barroso VM, Suter B, Jonas PM. Subcellular patch-clamp techniques for single-bouton stimulation and simultaneous pre- and postsynaptic recording at cortical synapses. <i>Nature Protocols</i>. 2021;16(6):2947–2967. doi:<a href=\"https://doi.org/10.1038/s41596-021-00526-0\">10.1038/s41596-021-00526-0</a>","chicago":"Vandael, David H, Yuji Okamoto, Carolina Borges Merjane, Victor M Vargas Barroso, Benjamin Suter, and Peter M Jonas. “Subcellular Patch-Clamp Techniques for Single-Bouton Stimulation and Simultaneous Pre- and Postsynaptic Recording at Cortical Synapses.” <i>Nature Protocols</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s41596-021-00526-0\">https://doi.org/10.1038/s41596-021-00526-0</a>.","short":"D.H. Vandael, Y. Okamoto, C. Borges Merjane, V.M. Vargas Barroso, B. Suter, P.M. Jonas, Nature Protocols 16 (2021) 2947–2967."},"ec_funded":1,"day":"01","language":[{"iso":"eng"}],"year":"2021","publication":"Nature Protocols","abstract":[{"text":"Rigorous investigation of synaptic transmission requires analysis of unitary synaptic events by simultaneous recording from presynaptic terminals and postsynaptic target neurons. However, this has been achieved at only a limited number of model synapses, including the squid giant synapse and the mammalian calyx of Held. Cortical presynaptic terminals have been largely inaccessible to direct presynaptic recording, due to their small size. Here, we describe a protocol for improved subcellular patch-clamp recording in rat and mouse brain slices, with the synapse in a largely intact environment. Slice preparation takes ~2 h, recording ~3 h and post hoc morphological analysis 2 d. Single presynaptic hippocampal mossy fiber terminals are stimulated minimally invasively in the bouton-attached configuration, in which the cytoplasmic content remains unperturbed, or in the whole-bouton configuration, in which the cytoplasmic composition can be precisely controlled. Paired pre–postsynaptic recordings can be integrated with biocytin labeling and morphological analysis, allowing correlative investigation of synapse structure and function. Paired recordings can be obtained from mossy fiber terminals in slices from both rats and mice, implying applicability to genetically modified synapses. Paired recordings can also be performed together with axon tract stimulation or optogenetic activation, allowing comparison of unitary and compound synaptic events in the same target cell. Finally, paired recordings can be combined with spontaneous event analysis, permitting collection of miniature events generated at a single identified synapse. In conclusion, the subcellular patch-clamp techniques detailed here should facilitate analysis of biophysics, plasticity and circuit function of cortical synapses in the mammalian central nervous system.","lang":"eng"}],"volume":16,"date_published":"2021-06-01T00:00:00Z","author":[{"orcid":"0000-0001-7577-1676","last_name":"Vandael","first_name":"David H","full_name":"Vandael, David H","id":"3AE48E0A-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Okamoto, Yuji","id":"3337E116-F248-11E8-B48F-1D18A9856A87","last_name":"Okamoto","first_name":"Yuji","orcid":"0000-0003-0408-6094"},{"full_name":"Borges Merjane, Carolina","id":"4305C450-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-0005-401X","last_name":"Borges Merjane","first_name":"Carolina"},{"last_name":"Vargas Barroso","first_name":"Victor M","full_name":"Vargas Barroso, Victor M","id":"2F55A9DE-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Suter","first_name":"Benjamin","orcid":"0000-0002-9885-6936","full_name":"Suter, Benjamin","id":"4952F31E-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Jonas","first_name":"Peter M","orcid":"0000-0001-5001-4804","full_name":"Jonas, Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87"}],"issue":"6","file_date_updated":"2021-12-02T23:30:05Z","project":[{"name":"Biophysics and circuit function of a giant cortical glumatergic synapse","_id":"25B7EB9E-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"692692"},{"_id":"25C5A090-B435-11E9-9278-68D0E5697425","name":"The Wittgenstein Prize","grant_number":"Z00312","call_identifier":"FWF"},{"_id":"2696E7FE-B435-11E9-9278-68D0E5697425","name":"Structural plasticity at mossy fiber-CA3 synapses","call_identifier":"FWF","grant_number":"V00739"}],"article_type":"original","date_created":"2021-05-30T22:01:24Z","scopus_import":"1","file":[{"file_id":"9639","date_created":"2021-07-08T12:27:55Z","creator":"cziletti","relation":"main_file","checksum":"7eb580abd8893cdb0b410cf41bc8c263","date_updated":"2021-12-02T23:30:05Z","content_type":"application/pdf","file_name":"VandaeletalAuthorVersion2021.pdf","file_size":38574802,"access_level":"open_access","embargo":"2021-12-01"}],"publisher":"Springer Nature","pmid":1},{"day":"20","language":[{"iso":"eng"}],"year":"2021","publication":"Nature Neuroscience","ec_funded":1,"volume":24,"abstract":[{"lang":"eng","text":"The ability to adapt to changes in stimulus statistics is a hallmark of sensory systems. Here, we developed a theoretical framework that can account for the dynamics of adaptation from an information processing perspective. We use this framework to optimize and analyze adaptive sensory codes, and we show that codes optimized for stationary environments can suffer from prolonged periods of poor performance when the environment changes. To mitigate the adversarial effects of these environmental changes, sensory systems must navigate tradeoffs between the ability to accurately encode incoming stimuli and the ability to rapidly detect and adapt to changes in the distribution of these stimuli. We derive families of codes that balance these objectives, and we demonstrate their close match to experimentally observed neural dynamics during mean and variance adaptation. Our results provide a unifying perspective on adaptation across a range of sensory systems, environments, and sensory tasks."}],"date_published":"2021-05-20T00:00:00Z","author":[{"id":"358A453A-F248-11E8-B48F-1D18A9856A87","full_name":"Mlynarski, Wiktor F","last_name":"Mlynarski","first_name":"Wiktor F"},{"full_name":"Hermundstad, Ann M.","last_name":"Hermundstad","first_name":"Ann M."}],"project":[{"grant_number":"754411","call_identifier":"H2020","name":"ISTplus - Postdoctoral Fellowships","_id":"260C2330-B435-11E9-9278-68D0E5697425"}],"article_type":"original","date_created":"2021-05-30T22:01:24Z","publisher":"Springer Nature","main_file_link":[{"url":"https://doi.org/10.1101/669200 ","open_access":"1"}],"scopus_import":"1","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","month":"05","oa_version":"Preprint","date_updated":"2023-08-08T13:51:14Z","publication_identifier":{"issn":["1097-6256"],"eissn":["1546-1726"]},"publication_status":"published","oa":1,"_id":"9439","page":"998-1009","intvolume":"        24","doi":"10.1038/s41593-021-00846-0","external_id":{"isi":["000652577300003"]},"department":[{"_id":"GaTk"}],"acknowledgement":"We thank D. Kastner and T. Münch for generously providing figures from their work. We also thank V. Jayaraman, M. Noorman, T. Ma, and K. Krishnamurthy for useful discussions and feedback on the manuscript. W.F.M. was funded by the European Union’s Horizon 2020 Research and Innovation Programme under Marie Skłodowska-Curie Grant Agreement No. 754411. A.M.H. was supported by the Howard Hughes Medical Institute.","quality_controlled":"1","isi":1,"citation":{"ieee":"W. F. Mlynarski and A. M. Hermundstad, “Efficient and adaptive sensory codes,” <i>Nature Neuroscience</i>, vol. 24. Springer Nature, pp. 998–1009, 2021.","ista":"Mlynarski WF, Hermundstad AM. 2021. Efficient and adaptive sensory codes. Nature Neuroscience. 24, 998–1009.","apa":"Mlynarski, W. F., &#38; Hermundstad, A. M. (2021). Efficient and adaptive sensory codes. <i>Nature Neuroscience</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41593-021-00846-0\">https://doi.org/10.1038/s41593-021-00846-0</a>","mla":"Mlynarski, Wiktor F., and Ann M. Hermundstad. “Efficient and Adaptive Sensory Codes.” <i>Nature Neuroscience</i>, vol. 24, Springer Nature, 2021, pp. 998–1009, doi:<a href=\"https://doi.org/10.1038/s41593-021-00846-0\">10.1038/s41593-021-00846-0</a>.","ama":"Mlynarski WF, Hermundstad AM. Efficient and adaptive sensory codes. <i>Nature Neuroscience</i>. 2021;24:998-1009. doi:<a href=\"https://doi.org/10.1038/s41593-021-00846-0\">10.1038/s41593-021-00846-0</a>","short":"W.F. Mlynarski, A.M. Hermundstad, Nature Neuroscience 24 (2021) 998–1009.","chicago":"Mlynarski, Wiktor F, and Ann M. Hermundstad. “Efficient and Adaptive Sensory Codes.” <i>Nature Neuroscience</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s41593-021-00846-0\">https://doi.org/10.1038/s41593-021-00846-0</a>."},"article_processing_charge":"No","type":"journal_article","status":"public","title":"Efficient and adaptive sensory codes"},{"author":[{"first_name":"Jean-Daniel","last_name":"Boissonnat","full_name":"Boissonnat, Jean-Daniel"},{"last_name":"Kachanovich","first_name":"Siargey","full_name":"Kachanovich, Siargey"},{"id":"307CFBC8-F248-11E8-B48F-1D18A9856A87","full_name":"Wintraecken, Mathijs","first_name":"Mathijs","last_name":"Wintraecken","orcid":"0000-0002-7472-2220"}],"date_published":"2021-06-02T00:00:00Z","abstract":[{"lang":"eng","text":"Isomanifolds are the generalization of isosurfaces to arbitrary dimension and codimension, i.e. submanifolds of ℝ^d defined as the zero set of some multivariate multivalued smooth function f: ℝ^d → ℝ^{d-n}, where n is the intrinsic dimension of the manifold. A natural way to approximate a smooth isomanifold M is to consider its Piecewise-Linear (PL) approximation M̂ based on a triangulation 𝒯 of the ambient space ℝ^d. In this paper, we describe a simple algorithm to trace isomanifolds from a given starting point. The algorithm works for arbitrary dimensions n and d, and any precision D. Our main result is that, when f (or M) has bounded complexity, the complexity of the algorithm is polynomial in d and δ = 1/D (and unavoidably exponential in n). Since it is known that for δ = Ω (d^{2.5}), M̂ is O(D²)-close and isotopic to M, our algorithm produces a faithful PL-approximation of isomanifolds of bounded complexity in time polynomial in d. Combining this algorithm with dimensionality reduction techniques, the dependency on d in the size of M̂ can be completely removed with high probability. We also show that the algorithm can handle isomanifolds with boundary and, more generally, isostratifolds. The algorithm for isomanifolds with boundary has been implemented and experimental results are reported, showing that it is practical and can handle cases that are far ahead of the state-of-the-art. "}],"volume":189,"file_date_updated":"2021-06-02T10:22:33Z","ec_funded":1,"publication":"37th International Symposium on Computational Geometry (SoCG 2021)","year":"2021","language":[{"iso":"eng"}],"day":"02","series_title":"Leibniz International Proceedings in Informatics (LIPIcs)","file":[{"success":1,"file_id":"9442","checksum":"c322aa48d5d35a35877896cc565705b6","relation":"main_file","creator":"mwintrae","date_created":"2021-06-02T10:22:33Z","content_type":"application/pdf","date_updated":"2021-06-02T10:22:33Z","file_size":1972902,"access_level":"open_access","file_name":"LIPIcs-SoCG-2021-17.pdf"}],"publisher":"Schloss Dagstuhl - Leibniz-Zentrum für Informatik","project":[{"call_identifier":"H2020","grant_number":"754411","name":"ISTplus - Postdoctoral Fellowships","_id":"260C2330-B435-11E9-9278-68D0E5697425"}],"date_created":"2021-06-02T10:10:55Z","has_accepted_license":"1","alternative_title":["LIPIcs"],"conference":{"end_date":"2021-06-11","name":"SoCG: Symposium on Computational Geometry","start_date":"2021-06-07","location":"Virtual"},"oa":1,"publication_status":"published","publication_identifier":{"isbn":["978-3-95977-184-9"],"issn":["1868-8969"]},"date_updated":"2023-10-10T07:34:34Z","ddc":["005","516","514"],"month":"06","oa_version":"Published Version","user_id":"D865714E-FA4E-11E9-B85B-F5C5E5697425","related_material":{"record":[{"id":"12960","relation":"later_version","status":"public"}]},"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"title":"Tracing isomanifolds in Rd in time polynomial in d using Coxeter-Freudenthal-Kuhn triangulations","type":"conference","status":"public","citation":{"ieee":"J.-D. Boissonnat, S. Kachanovich, and M. Wintraecken, “Tracing isomanifolds in Rd in time polynomial in d using Coxeter-Freudenthal-Kuhn triangulations,” in <i>37th International Symposium on Computational Geometry (SoCG 2021)</i>, Virtual, 2021, vol. 189, p. 17:1-17:16.","ista":"Boissonnat J-D, Kachanovich S, Wintraecken M. 2021. Tracing isomanifolds in Rd in time polynomial in d using Coxeter-Freudenthal-Kuhn triangulations. 37th International Symposium on Computational Geometry (SoCG 2021). SoCG: Symposium on Computational GeometryLeibniz International Proceedings in Informatics (LIPIcs), LIPIcs, vol. 189, 17:1-17:16.","apa":"Boissonnat, J.-D., Kachanovich, S., &#38; Wintraecken, M. (2021). Tracing isomanifolds in Rd in time polynomial in d using Coxeter-Freudenthal-Kuhn triangulations. In <i>37th International Symposium on Computational Geometry (SoCG 2021)</i> (Vol. 189, p. 17:1-17:16). Dagstuhl, Germany: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. <a href=\"https://doi.org/10.4230/LIPIcs.SoCG.2021.17\">https://doi.org/10.4230/LIPIcs.SoCG.2021.17</a>","mla":"Boissonnat, Jean-Daniel, et al. “Tracing Isomanifolds in Rd in Time Polynomial in d Using Coxeter-Freudenthal-Kuhn Triangulations.” <i>37th International Symposium on Computational Geometry (SoCG 2021)</i>, vol. 189, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2021, p. 17:1-17:16, doi:<a href=\"https://doi.org/10.4230/LIPIcs.SoCG.2021.17\">10.4230/LIPIcs.SoCG.2021.17</a>.","ama":"Boissonnat J-D, Kachanovich S, Wintraecken M. Tracing isomanifolds in Rd in time polynomial in d using Coxeter-Freudenthal-Kuhn triangulations. In: <i>37th International Symposium on Computational Geometry (SoCG 2021)</i>. Vol 189. Leibniz International Proceedings in Informatics (LIPIcs). Dagstuhl, Germany: Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2021:17:1-17:16. doi:<a href=\"https://doi.org/10.4230/LIPIcs.SoCG.2021.17\">10.4230/LIPIcs.SoCG.2021.17</a>","short":"J.-D. Boissonnat, S. Kachanovich, M. Wintraecken, in:, 37th International Symposium on Computational Geometry (SoCG 2021), Schloss Dagstuhl - Leibniz-Zentrum für Informatik, Dagstuhl, Germany, 2021, p. 17:1-17:16.","chicago":"Boissonnat, Jean-Daniel, Siargey Kachanovich, and Mathijs Wintraecken. “Tracing Isomanifolds in Rd in Time Polynomial in d Using Coxeter-Freudenthal-Kuhn Triangulations.” In <i>37th International Symposium on Computational Geometry (SoCG 2021)</i>, 189:17:1-17:16. Leibniz International Proceedings in Informatics (LIPIcs). Dagstuhl, Germany: Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2021. <a href=\"https://doi.org/10.4230/LIPIcs.SoCG.2021.17\">https://doi.org/10.4230/LIPIcs.SoCG.2021.17</a>."},"article_processing_charge":"No","quality_controlled":"1","acknowledgement":"We thank Dominique Attali, Guilherme de Fonseca, Arijit Ghosh, Vincent Pilaud and Aurélien Alvarez for their comments and suggestions. We also acknowledge the reviewers.","place":"Dagstuhl, Germany","department":[{"_id":"HeEd"}],"doi":"10.4230/LIPIcs.SoCG.2021.17","intvolume":"       189","_id":"9441","page":"17:1-17:16"}]