[{"language":[{"iso":"eng"}],"article_processing_charge":"No","volume":220,"has_accepted_license":"1","month":"03","issue":"4","article_number":"e202003052","file":[{"success":1,"relation":"main_file","creator":"dernst","checksum":"4739ffd90f2c7e05ac5b00f057c58aa2","file_id":"9310","file_size":9019720,"access_level":"open_access","content_type":"application/pdf","date_updated":"2021-04-06T10:39:08Z","date_created":"2021-04-06T10:39:08Z","file_name":"2021_JCB_Dobramysl.pdf"}],"author":[{"last_name":"Dobramysl","first_name":"Ulrich","full_name":"Dobramysl, Ulrich"},{"first_name":"Iris Katharina","last_name":"Jarsch","full_name":"Jarsch, Iris Katharina"},{"last_name":"Inoue","first_name":"Yoshiko","full_name":"Inoue, Yoshiko"},{"first_name":"Hanae","last_name":"Shimo","full_name":"Shimo, Hanae"},{"full_name":"Richier, Benjamin","last_name":"Richier","first_name":"Benjamin"},{"full_name":"Gadsby, Jonathan R.","last_name":"Gadsby","first_name":"Jonathan R."},{"last_name":"Mason","first_name":"Julia","full_name":"Mason, Julia"},{"full_name":"Szałapak, Alicja","first_name":"Alicja","last_name":"Szałapak"},{"first_name":"Pantelis Savvas","last_name":"Ioannou","full_name":"Ioannou, Pantelis Savvas"},{"full_name":"Correia, Guilherme Pereira","first_name":"Guilherme Pereira","last_name":"Correia"},{"full_name":"Walrant, Astrid","first_name":"Astrid","last_name":"Walrant"},{"first_name":"Richard","last_name":"Butler","full_name":"Butler, Richard"},{"id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","full_name":"Hannezo, Edouard B","last_name":"Hannezo","first_name":"Edouard B","orcid":"0000-0001-6005-1561"},{"first_name":"Benjamin D.","last_name":"Simons","full_name":"Simons, Benjamin D."},{"full_name":"Gallop, Jennifer L.","first_name":"Jennifer L.","last_name":"Gallop"}],"project":[{"call_identifier":"FWF","grant_number":"P31639","_id":"268294B6-B435-11E9-9278-68D0E5697425","name":"Active mechano-chemical description of the cell cytoskeleton"}],"quality_controlled":"1","oa_version":"Published Version","publication_identifier":{"eissn":["15408140"]},"status":"public","date_created":"2021-04-04T22:01:21Z","type":"journal_article","_id":"9306","article_type":"original","publisher":"Rockefeller University Press","date_published":"2021-03-19T00:00:00Z","file_date_updated":"2021-04-06T10:39:08Z","pmid":1,"title":"Stochastic combinations of actin regulatory proteins are sufficient to drive filopodia formation","abstract":[{"text":"Assemblies of actin and its regulators underlie the dynamic morphology of all eukaryotic cells. To understand how actin regulatory proteins work together to generate actin-rich structures such as filopodia, we analyzed the localization of diverse actin regulators within filopodia in Drosophila embryos and in a complementary in vitro system of filopodia-like structures (FLSs). We found that the composition of the regulatory protein complex where actin is incorporated (the filopodial tip complex) is remarkably heterogeneous both in vivo and in vitro. Our data reveal that different pairs of proteins correlate with each other and with actin bundle length, suggesting the presence of functional subcomplexes. This is consistent with a theoretical framework where three or more redundant subcomplexes join the tip complex stochastically, with any two being sufficient to drive filopodia formation. We provide an explanation for the observed heterogeneity and suggest that a mechanism based on multiple components allows stereotypical filopodial dynamics to arise from diverse upstream signaling pathways.","lang":"eng"}],"publication_status":"published","ddc":["576"],"isi":1,"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"external_id":{"pmid":["33740033"],"isi":["000663160600002"]},"date_updated":"2023-08-07T14:32:28Z","department":[{"_id":"EdHa"}],"citation":{"apa":"Dobramysl, U., Jarsch, I. K., Inoue, Y., Shimo, H., Richier, B., Gadsby, J. R., … Gallop, J. L. (2021). Stochastic combinations of actin regulatory proteins are sufficient to drive filopodia formation. <i>Journal of Cell Biology</i>. Rockefeller University Press. <a href=\"https://doi.org/10.1083/jcb.202003052\">https://doi.org/10.1083/jcb.202003052</a>","ista":"Dobramysl U, Jarsch IK, Inoue Y, Shimo H, Richier B, Gadsby JR, Mason J, Szałapak A, Ioannou PS, Correia GP, Walrant A, Butler R, Hannezo EB, Simons BD, Gallop JL. 2021. Stochastic combinations of actin regulatory proteins are sufficient to drive filopodia formation. Journal of Cell Biology. 220(4), e202003052.","ama":"Dobramysl U, Jarsch IK, Inoue Y, et al. Stochastic combinations of actin regulatory proteins are sufficient to drive filopodia formation. <i>Journal of Cell Biology</i>. 2021;220(4). doi:<a href=\"https://doi.org/10.1083/jcb.202003052\">10.1083/jcb.202003052</a>","chicago":"Dobramysl, Ulrich, Iris Katharina Jarsch, Yoshiko Inoue, Hanae Shimo, Benjamin Richier, Jonathan R. Gadsby, Julia Mason, et al. “Stochastic Combinations of Actin Regulatory Proteins Are Sufficient to Drive Filopodia Formation.” <i>Journal of Cell Biology</i>. Rockefeller University Press, 2021. <a href=\"https://doi.org/10.1083/jcb.202003052\">https://doi.org/10.1083/jcb.202003052</a>.","ieee":"U. Dobramysl <i>et al.</i>, “Stochastic combinations of actin regulatory proteins are sufficient to drive filopodia formation,” <i>Journal of Cell Biology</i>, vol. 220, no. 4. Rockefeller University Press, 2021.","short":"U. Dobramysl, I.K. Jarsch, Y. Inoue, H. Shimo, B. Richier, J.R. Gadsby, J. Mason, A. Szałapak, P.S. Ioannou, G.P. Correia, A. Walrant, R. Butler, E.B. Hannezo, B.D. Simons, J.L. Gallop, Journal of Cell Biology 220 (2021).","mla":"Dobramysl, Ulrich, et al. “Stochastic Combinations of Actin Regulatory Proteins Are Sufficient to Drive Filopodia Formation.” <i>Journal of Cell Biology</i>, vol. 220, no. 4, e202003052, Rockefeller University Press, 2021, doi:<a href=\"https://doi.org/10.1083/jcb.202003052\">10.1083/jcb.202003052</a>."},"intvolume":"       220","publication":"Journal of Cell Biology","scopus_import":"1","acknowledgement":"This work was supported by European Research Council grant 281971, Wellcome Trust Research Career Development Fellowship WT095829AIA and Wellcome Trust Senior Research\r\nFellowship 219482/Z/19/Z to J.L. Gallop, a Wellcome Trust Senior Investigator Award 098357 to B.D. Simons, and an Austrian Science Fund grant (P31639) to E. Hannezo. We acknowledge\r\ncore funding by the Wellcome Trust (092096) and Cancer Research UK (C6946/A14492). U. Dobramysl was supported by a Wellcome Trust Junior Interdisciplinary Fellowship grant\r\n(105602/Z/14/Z) and a Herchel Smith Postdoctoral Fellowship. H. Shimo was supported by a Funai Foundation Overseas scholarship.","doi":"10.1083/jcb.202003052","year":"2021","day":"19","oa":1},{"publisher":"Springer Nature","file_date_updated":"2021-04-06T09:31:28Z","date_published":"2021-03-21T00:00:00Z","title":"Finite time extinction for the 1D stochastic porous medium equation with transport noise","abstract":[{"text":"We establish finite time extinction with probability one for weak solutions of the Cauchy–Dirichlet problem for the 1D stochastic porous medium equation with Stratonovich transport noise and compactly supported smooth initial datum. Heuristically, this is expected to hold because Brownian motion has average spread rate O(t12) whereas the support of solutions to the deterministic PME grows only with rate O(t1m+1). The rigorous proof relies on a contraction principle up to time-dependent shift for Wong–Zakai type approximations, the transformation to a deterministic PME with two copies of a Brownian path as the lateral boundary, and techniques from the theory of viscosity solutions.","lang":"eng"}],"publication_status":"published","ddc":["510"],"isi":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","external_id":{"isi":["000631001700001"]},"date_updated":"2023-08-07T14:31:59Z","department":[{"_id":"JuFi"}],"citation":{"apa":"Hensel, S. (2021). Finite time extinction for the 1D stochastic porous medium equation with transport noise. <i>Stochastics and Partial Differential Equations: Analysis and Computations</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s40072-021-00188-9\">https://doi.org/10.1007/s40072-021-00188-9</a>","chicago":"Hensel, Sebastian. “Finite Time Extinction for the 1D Stochastic Porous Medium Equation with Transport Noise.” <i>Stochastics and Partial Differential Equations: Analysis and Computations</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1007/s40072-021-00188-9\">https://doi.org/10.1007/s40072-021-00188-9</a>.","ista":"Hensel S. 2021. Finite time extinction for the 1D stochastic porous medium equation with transport noise. Stochastics and Partial Differential Equations: Analysis and Computations. 9, 892–939.","ama":"Hensel S. Finite time extinction for the 1D stochastic porous medium equation with transport noise. <i>Stochastics and Partial Differential Equations: Analysis and Computations</i>. 2021;9:892–939. doi:<a href=\"https://doi.org/10.1007/s40072-021-00188-9\">10.1007/s40072-021-00188-9</a>","ieee":"S. Hensel, “Finite time extinction for the 1D stochastic porous medium equation with transport noise,” <i>Stochastics and Partial Differential Equations: Analysis and Computations</i>, vol. 9. Springer Nature, pp. 892–939, 2021.","short":"S. Hensel, Stochastics and Partial Differential Equations: Analysis and Computations 9 (2021) 892–939.","mla":"Hensel, Sebastian. “Finite Time Extinction for the 1D Stochastic Porous Medium Equation with Transport Noise.” <i>Stochastics and Partial Differential Equations: Analysis and Computations</i>, vol. 9, Springer Nature, 2021, pp. 892–939, doi:<a href=\"https://doi.org/10.1007/s40072-021-00188-9\">10.1007/s40072-021-00188-9</a>."},"intvolume":"         9","publication":"Stochastics and Partial Differential Equations: Analysis and Computations","scopus_import":"1","acknowledgement":"This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Grant Agreement No. 665385 . I am very grateful to M. Gerencsér and J. Maas for proposing this problem as well as helpful discussions. Special thanks go to F. Cornalba for suggesting the additional κ-truncation in Proposition 5. I am also indebted to an anonymous referee for pointing out a gap in a previous version of the proof of Lemma 9 (concerning the treatment of the noise term). The issue is resolved in this version.","day":"21","page":"892–939","doi":"10.1007/s40072-021-00188-9","year":"2021","oa":1,"language":[{"iso":"eng"}],"article_processing_charge":"Yes (via OA deal)","volume":9,"month":"03","has_accepted_license":"1","file":[{"access_level":"open_access","file_size":727005,"checksum":"6529b609c9209861720ffa4685111bc6","file_id":"9309","creator":"dernst","success":1,"relation":"main_file","file_name":"2021_StochPartDiffEquation_Hensel.pdf","date_created":"2021-04-06T09:31:28Z","date_updated":"2021-04-06T09:31:28Z","content_type":"application/pdf"}],"author":[{"last_name":"Hensel","first_name":"Sebastian","orcid":"0000-0001-7252-8072","id":"4D23B7DA-F248-11E8-B48F-1D18A9856A87","full_name":"Hensel, Sebastian"}],"project":[{"grant_number":"665385","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","name":"International IST Doctoral Program","call_identifier":"H2020"}],"quality_controlled":"1","oa_version":"Published Version","ec_funded":1,"status":"public","publication_identifier":{"eissn":["2194-041X"],"issn":["2194-0401"]},"date_created":"2021-04-04T22:01:21Z","_id":"9307","type":"journal_article","article_type":"original"},{"issue":"2","article_number":"75","month":"03","article_processing_charge":"No","volume":76,"language":[{"iso":"eng"}],"oa_version":"None","quality_controlled":"1","author":[{"last_name":"Iyiola","first_name":"Olaniyi S.","full_name":"Iyiola, Olaniyi S."},{"full_name":"Shehu, Yekini","id":"3FC7CB58-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-9224-7139","first_name":"Yekini","last_name":"Shehu"}],"_id":"9315","type":"journal_article","article_type":"original","date_created":"2021-04-11T22:01:14Z","publication_identifier":{"issn":["1422-6383"],"eissn":["1420-9012"]},"status":"public","isi":1,"abstract":[{"text":"We consider inertial iteration methods for Fermat–Weber location problem and primal–dual three-operator splitting in real Hilbert spaces. To do these, we first obtain weak convergence analysis and nonasymptotic O(1/n) convergence rate of the inertial Krasnoselskii–Mann iteration for fixed point of nonexpansive operators in infinite dimensional real Hilbert spaces under some seemingly easy to implement conditions on the iterative parameters. One of our contributions is that the convergence analysis and rate of convergence results are obtained using conditions which appear not complicated and restrictive as assumed in other previous related results in the literature. We then show that Fermat–Weber location problem and primal–dual three-operator splitting are special cases of fixed point problem of nonexpansive mapping and consequently obtain the convergence analysis of inertial iteration methods for Fermat–Weber location problem and primal–dual three-operator splitting in real Hilbert spaces. Some numerical implementations are drawn from primal–dual three-operator splitting to support the theoretical analysis.","lang":"eng"}],"publication_status":"published","title":"New convergence results for inertial Krasnoselskii–Mann iterations in Hilbert spaces with applications","date_published":"2021-03-25T00:00:00Z","publisher":"Springer Nature","citation":{"ieee":"O. S. Iyiola and Y. Shehu, “New convergence results for inertial Krasnoselskii–Mann iterations in Hilbert spaces with applications,” <i>Results in Mathematics</i>, vol. 76, no. 2. Springer Nature, 2021.","apa":"Iyiola, O. S., &#38; Shehu, Y. (2021). New convergence results for inertial Krasnoselskii–Mann iterations in Hilbert spaces with applications. <i>Results in Mathematics</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00025-021-01381-x\">https://doi.org/10.1007/s00025-021-01381-x</a>","ista":"Iyiola OS, Shehu Y. 2021. New convergence results for inertial Krasnoselskii–Mann iterations in Hilbert spaces with applications. Results in Mathematics. 76(2), 75.","chicago":"Iyiola, Olaniyi S., and Yekini Shehu. “New Convergence Results for Inertial Krasnoselskii–Mann Iterations in Hilbert Spaces with Applications.” <i>Results in Mathematics</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1007/s00025-021-01381-x\">https://doi.org/10.1007/s00025-021-01381-x</a>.","ama":"Iyiola OS, Shehu Y. New convergence results for inertial Krasnoselskii–Mann iterations in Hilbert spaces with applications. <i>Results in Mathematics</i>. 2021;76(2). doi:<a href=\"https://doi.org/10.1007/s00025-021-01381-x\">10.1007/s00025-021-01381-x</a>","mla":"Iyiola, Olaniyi S., and Yekini Shehu. “New Convergence Results for Inertial Krasnoselskii–Mann Iterations in Hilbert Spaces with Applications.” <i>Results in Mathematics</i>, vol. 76, no. 2, 75, Springer Nature, 2021, doi:<a href=\"https://doi.org/10.1007/s00025-021-01381-x\">10.1007/s00025-021-01381-x</a>.","short":"O.S. Iyiola, Y. Shehu, Results in Mathematics 76 (2021)."},"date_updated":"2023-10-10T09:47:33Z","department":[{"_id":"VlKo"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","external_id":{"isi":["000632917700001"]},"scopus_import":"1","publication":"Results in Mathematics","intvolume":"        76","day":"25","doi":"10.1007/s00025-021-01381-x","year":"2021","acknowledgement":"The research of this author is supported by the Postdoctoral Fellowship from Institute of Science and Technology (IST), Austria."},{"status":"public","publication_identifier":{"issn":["00928674"],"eissn":["10974172"]},"date_created":"2021-04-11T22:01:14Z","type":"journal_article","_id":"9316","article_type":"original","ec_funded":1,"author":[{"full_name":"Petridou, Nicoletta","id":"2A003F6C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8451-1195","first_name":"Nicoletta","last_name":"Petridou"},{"id":"43BE2298-F248-11E8-B48F-1D18A9856A87","full_name":"Corominas-Murtra, Bernat","last_name":"Corominas-Murtra","first_name":"Bernat","orcid":"0000-0001-9806-5643"},{"full_name":"Heisenberg, Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0912-4566","first_name":"Carl-Philipp J","last_name":"Heisenberg"},{"id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","full_name":"Hannezo, Edouard B","first_name":"Edouard B","last_name":"Hannezo","orcid":"0000-0001-6005-1561"}],"quality_controlled":"1","project":[{"name":"Interaction and feedback between cell mechanics and fate specification in vertebrate gastrulation","grant_number":"742573","_id":"260F1432-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"},{"call_identifier":"H2020","name":"Design Principles of Branching Morphogenesis","grant_number":"851288","_id":"05943252-7A3F-11EA-A408-12923DDC885E"},{"name":"Tissue material properties in embryonic development","grant_number":"V00736","_id":"2693FD8C-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"}],"oa_version":"Published Version","language":[{"iso":"eng"}],"article_processing_charge":"No","acknowledged_ssus":[{"_id":"Bio"},{"_id":"PreCl"}],"volume":184,"month":"04","has_accepted_license":"1","issue":"7","file":[{"success":1,"relation":"main_file","creator":"cziletti","checksum":"1e5295fbd9c2a459173ec45a0e8a7c2e","file_id":"9534","file_size":11405875,"access_level":"open_access","content_type":"application/pdf","date_updated":"2021-06-08T10:04:10Z","date_created":"2021-06-08T10:04:10Z","file_name":"2021_Cell_Petridou.pdf"}],"acknowledgement":"We thank Carl Goodrich and the members of the Heisenberg and Hannezo groups, in particular Reka Korei, for help, technical advice, and discussions; and the Bioimaging and zebrafish facilities of the IST Austria for continuous support. This work was supported by the Elise Richter Program of Austrian Science Fund (FWF) to N.I.P. ( V 736-B26 ) and the European Union (European Research Council Advanced Grant 742573 to C.-P.H. and European Research Council Starting Grant 851288 to E.H.).","year":"2021","day":"01","doi":"10.1016/j.cell.2021.02.017","page":"1914-1928.e19","oa":1,"intvolume":"       184","publication":"Cell","related_material":{"link":[{"description":"News on IST Homepage","url":"https://ist.ac.at/en/news/embryonic-tissue-undergoes-phase-transition/","relation":"press_release"}]},"scopus_import":"1","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"external_id":{"isi":["000636734000022"],"pmid":["33730596"]},"date_updated":"2023-08-07T14:33:59Z","department":[{"_id":"CaHe"},{"_id":"EdHa"}],"citation":{"ista":"Petridou N, Corominas-Murtra B, Heisenberg C-PJ, Hannezo EB. 2021. Rigidity percolation uncovers a structural basis for embryonic tissue phase transitions. Cell. 184(7), 1914–1928.e19.","ama":"Petridou N, Corominas-Murtra B, Heisenberg C-PJ, Hannezo EB. Rigidity percolation uncovers a structural basis for embryonic tissue phase transitions. <i>Cell</i>. 2021;184(7):1914-1928.e19. doi:<a href=\"https://doi.org/10.1016/j.cell.2021.02.017\">10.1016/j.cell.2021.02.017</a>","chicago":"Petridou, Nicoletta, Bernat Corominas-Murtra, Carl-Philipp J Heisenberg, and Edouard B Hannezo. “Rigidity Percolation Uncovers a Structural Basis for Embryonic Tissue Phase Transitions.” <i>Cell</i>. Elsevier, 2021. <a href=\"https://doi.org/10.1016/j.cell.2021.02.017\">https://doi.org/10.1016/j.cell.2021.02.017</a>.","apa":"Petridou, N., Corominas-Murtra, B., Heisenberg, C.-P. J., &#38; Hannezo, E. B. (2021). Rigidity percolation uncovers a structural basis for embryonic tissue phase transitions. <i>Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cell.2021.02.017\">https://doi.org/10.1016/j.cell.2021.02.017</a>","ieee":"N. Petridou, B. Corominas-Murtra, C.-P. J. Heisenberg, and E. B. Hannezo, “Rigidity percolation uncovers a structural basis for embryonic tissue phase transitions,” <i>Cell</i>, vol. 184, no. 7. Elsevier, p. 1914–1928.e19, 2021.","short":"N. Petridou, B. Corominas-Murtra, C.-P.J. Heisenberg, E.B. Hannezo, Cell 184 (2021) 1914–1928.e19.","mla":"Petridou, Nicoletta, et al. “Rigidity Percolation Uncovers a Structural Basis for Embryonic Tissue Phase Transitions.” <i>Cell</i>, vol. 184, no. 7, Elsevier, 2021, p. 1914–1928.e19, doi:<a href=\"https://doi.org/10.1016/j.cell.2021.02.017\">10.1016/j.cell.2021.02.017</a>."},"publisher":"Elsevier","file_date_updated":"2021-06-08T10:04:10Z","date_published":"2021-04-01T00:00:00Z","pmid":1,"title":"Rigidity percolation uncovers a structural basis for embryonic tissue phase transitions","abstract":[{"lang":"eng","text":"Embryo morphogenesis is impacted by dynamic changes in tissue material properties, which have been proposed to occur via processes akin to phase transitions (PTs). Here, we show that rigidity percolation provides a simple and robust theoretical framework to predict material/structural PTs of embryonic tissues from local cell connectivity. By using percolation theory, combined with directly monitoring dynamic changes in tissue rheology and cell contact mechanics, we demonstrate that the zebrafish blastoderm undergoes a genuine rigidity PT, brought about by a small reduction in adhesion-dependent cell connectivity below a critical value. We quantitatively predict and experimentally verify hallmarks of PTs, including power-law exponents and associated discontinuities of macroscopic observables. Finally, we show that this uniform PT depends on blastoderm cells undergoing meta-synchronous divisions causing random and, consequently, uniform changes in cell connectivity. Collectively, our theoretical and experimental findings reveal the structural basis of material PTs in an organismal context."}],"publication_status":"published","ddc":["570"],"isi":1},{"publication":"Discrete and Computational Geometry","intvolume":"        65","related_material":{"record":[{"status":"public","id":"187","relation":"earlier_version"}]},"scopus_import":"1","year":"2021","doi":"10.1007/s00454-021-00281-9","page":"1296–1313","day":"31","acknowledgement":"This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant Agreement No. 78818 Alpha), and by the DFG Collaborative Research Center TRR 109, ‘Discretization in Geometry and Dynamics’, through Grant No. I02979-N35 of the Austrian Science Fund (FWF)\r\nOpen Access funding provided by the Institute of Science and Technology (IST Austria).","oa":1,"title":"The multi-cover persistence of Euclidean balls","publisher":"Springer Nature","file_date_updated":"2021-12-01T10:56:53Z","date_published":"2021-03-31T00:00:00Z","isi":1,"ddc":["516"],"abstract":[{"lang":"eng","text":"Given a locally finite X⊆Rd and a radius r≥0, the k-fold cover of X and r consists of all points in Rd that have k or more points of X within distance r. We consider two filtrations—one in scale obtained by fixing k and increasing r, and the other in depth obtained by fixing r and decreasing k—and we compute the persistence diagrams of both. While standard methods suffice for the filtration in scale, we need novel geometric and topological concepts for the filtration in depth. In particular, we introduce a rhomboid tiling in Rd+1 whose horizontal integer slices are the order-k Delaunay mosaics of X, and construct a zigzag module of Delaunay mosaics that is isomorphic to the persistence module of the multi-covers."}],"publication_status":"published","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"external_id":{"isi":["000635460400001"]},"citation":{"short":"H. Edelsbrunner, G.F. Osang, Discrete and Computational Geometry 65 (2021) 1296–1313.","mla":"Edelsbrunner, Herbert, and Georg F. Osang. “The Multi-Cover Persistence of Euclidean Balls.” <i>Discrete and Computational Geometry</i>, vol. 65, Springer Nature, 2021, pp. 1296–1313, doi:<a href=\"https://doi.org/10.1007/s00454-021-00281-9\">10.1007/s00454-021-00281-9</a>.","ista":"Edelsbrunner H, Osang GF. 2021. The multi-cover persistence of Euclidean balls. Discrete and Computational Geometry. 65, 1296–1313.","chicago":"Edelsbrunner, Herbert, and Georg F Osang. “The Multi-Cover Persistence of Euclidean Balls.” <i>Discrete and Computational Geometry</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1007/s00454-021-00281-9\">https://doi.org/10.1007/s00454-021-00281-9</a>.","ama":"Edelsbrunner H, Osang GF. The multi-cover persistence of Euclidean balls. <i>Discrete and Computational Geometry</i>. 2021;65:1296–1313. doi:<a href=\"https://doi.org/10.1007/s00454-021-00281-9\">10.1007/s00454-021-00281-9</a>","apa":"Edelsbrunner, H., &#38; Osang, G. F. (2021). The multi-cover persistence of Euclidean balls. <i>Discrete and Computational Geometry</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00454-021-00281-9\">https://doi.org/10.1007/s00454-021-00281-9</a>","ieee":"H. Edelsbrunner and G. F. Osang, “The multi-cover persistence of Euclidean balls,” <i>Discrete and Computational Geometry</i>, vol. 65. Springer Nature, pp. 1296–1313, 2021."},"date_updated":"2023-08-07T14:35:44Z","department":[{"_id":"HeEd"}],"ec_funded":1,"status":"public","publication_identifier":{"issn":["0179-5376"],"eissn":["1432-0444"]},"_id":"9317","type":"journal_article","article_type":"original","date_created":"2021-04-11T22:01:15Z","article_processing_charge":"Yes (via OA deal)","volume":65,"language":[{"iso":"eng"}],"file":[{"date_created":"2021-12-01T10:56:53Z","date_updated":"2021-12-01T10:56:53Z","content_type":"application/pdf","file_name":"2021_DisCompGeo_Edelsbrunner_Osang.pdf","success":1,"relation":"main_file","access_level":"open_access","file_size":677704,"file_id":"10394","checksum":"59b4e1e827e494209bcb4aae22e1d347","creator":"cchlebak"}],"month":"03","has_accepted_license":"1","author":[{"orcid":"0000-0002-9823-6833","last_name":"Edelsbrunner","first_name":"Herbert","full_name":"Edelsbrunner, Herbert","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Osang, Georg F","id":"464B40D6-F248-11E8-B48F-1D18A9856A87","first_name":"Georg F","last_name":"Osang"}],"oa_version":"Published Version","project":[{"grant_number":"788183","_id":"266A2E9E-B435-11E9-9278-68D0E5697425","name":"Alpha Shape Theory Extended","call_identifier":"H2020"},{"call_identifier":"FWF","grant_number":"I02979-N35","_id":"2561EBF4-B435-11E9-9278-68D0E5697425","name":"Persistence and stability of geometric complexes"}],"quality_controlled":"1"},{"type":"journal_article","_id":"9318","article_type":"original","date_created":"2021-04-11T22:01:15Z","publication_identifier":{"eissn":["20505094"]},"status":"public","ec_funded":1,"oa_version":"Published Version","project":[{"call_identifier":"H2020","_id":"260C2330-B435-11E9-9278-68D0E5697425","grant_number":"754411","name":"ISTplus - Postdoctoral Fellowships"},{"call_identifier":"H2020","name":"Analysis of quantum many-body systems","_id":"25C6DC12-B435-11E9-9278-68D0E5697425","grant_number":"694227"}],"quality_controlled":"1","author":[{"id":"A2E3BCBE-5FCC-11E9-AA4B-76F3E5697425","full_name":"Bossmann, Lea","last_name":"Bossmann","first_name":"Lea","orcid":"0000-0002-6854-1343"},{"full_name":"Petrat, Sören P","id":"40AC02DC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-9166-5889","first_name":"Sören P","last_name":"Petrat"},{"id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","full_name":"Seiringer, Robert","last_name":"Seiringer","first_name":"Robert","orcid":"0000-0002-6781-0521"}],"file":[{"relation":"main_file","success":1,"file_size":883851,"access_level":"open_access","creator":"dernst","file_id":"9319","checksum":"17a3e6786d1e930cf0c14a880a6d7e92","date_updated":"2021-04-12T07:15:58Z","date_created":"2021-04-12T07:15:58Z","content_type":"application/pdf","file_name":"2021_ForumMath_Bossmann.pdf"}],"article_number":"e28","has_accepted_license":"1","month":"03","article_processing_charge":"Yes (via OA deal)","volume":9,"language":[{"iso":"eng"}],"oa":1,"day":"26","year":"2021","doi":"10.1017/fms.2021.22","acknowledgement":"The first author gratefully acknowledges funding from the European Union’s Horizon 2020 research and innovation programme under Marie Skłodowska-Curie Grant Agreement No. 754411. The third author was supported by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant Agreement No. 694227).","scopus_import":"1","publication":"Forum of Mathematics, Sigma","intvolume":"         9","citation":{"ieee":"L. Bossmann, S. P. Petrat, and R. Seiringer, “Asymptotic expansion of low-energy excitations for weakly interacting bosons,” <i>Forum of Mathematics, Sigma</i>, vol. 9. Cambridge University Press, 2021.","ama":"Bossmann L, Petrat SP, Seiringer R. Asymptotic expansion of low-energy excitations for weakly interacting bosons. <i>Forum of Mathematics, Sigma</i>. 2021;9. doi:<a href=\"https://doi.org/10.1017/fms.2021.22\">10.1017/fms.2021.22</a>","chicago":"Bossmann, Lea, Sören P Petrat, and Robert Seiringer. “Asymptotic Expansion of Low-Energy Excitations for Weakly Interacting Bosons.” <i>Forum of Mathematics, Sigma</i>. Cambridge University Press, 2021. <a href=\"https://doi.org/10.1017/fms.2021.22\">https://doi.org/10.1017/fms.2021.22</a>.","ista":"Bossmann L, Petrat SP, Seiringer R. 2021. Asymptotic expansion of low-energy excitations for weakly interacting bosons. Forum of Mathematics, Sigma. 9, e28.","apa":"Bossmann, L., Petrat, S. P., &#38; Seiringer, R. (2021). Asymptotic expansion of low-energy excitations for weakly interacting bosons. <i>Forum of Mathematics, Sigma</i>. Cambridge University Press. <a href=\"https://doi.org/10.1017/fms.2021.22\">https://doi.org/10.1017/fms.2021.22</a>","mla":"Bossmann, Lea, et al. “Asymptotic Expansion of Low-Energy Excitations for Weakly Interacting Bosons.” <i>Forum of Mathematics, Sigma</i>, vol. 9, e28, Cambridge University Press, 2021, doi:<a href=\"https://doi.org/10.1017/fms.2021.22\">10.1017/fms.2021.22</a>.","short":"L. Bossmann, S.P. Petrat, R. Seiringer, Forum of Mathematics, Sigma 9 (2021)."},"date_updated":"2023-08-07T14:35:06Z","department":[{"_id":"RoSe"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"external_id":{"isi":["000634006900001"]},"ddc":["510"],"isi":1,"abstract":[{"text":"We consider a system of N bosons in the mean-field scaling regime for a class of interactions including the repulsive Coulomb potential. We derive an asymptotic expansion of the low-energy eigenstates and the corresponding energies, which provides corrections to Bogoliubov theory to any order in 1/N.","lang":"eng"}],"publication_status":"published","title":"Asymptotic expansion of low-energy excitations for weakly interacting bosons","file_date_updated":"2021-04-12T07:15:58Z","publisher":"Cambridge University Press","date_published":"2021-03-26T00:00:00Z"},{"author":[{"first_name":"Daniel","last_name":"Jirovec","orcid":"0000-0002-7197-4801","id":"4C473F58-F248-11E8-B48F-1D18A9856A87","full_name":"Jirovec, Daniel"}],"tmp":{"short":"CC0 (1.0)","name":"Creative Commons Public Domain Dedication (CC0 1.0)","legal_code_url":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","image":"/images/cc_0.png"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2024-02-21T12:39:15Z","department":[{"_id":"GradSch"},{"_id":"GeKa"}],"citation":{"apa":"Jirovec, D. (2021). Research data for “A singlet-triplet hole spin qubit planar Ge.” Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:9323\">https://doi.org/10.15479/AT:ISTA:9323</a>","ista":"Jirovec D. 2021. Research data for ‘A singlet-triplet hole spin qubit planar Ge’, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:9323\">10.15479/AT:ISTA:9323</a>.","ama":"Jirovec D. Research data for “A singlet-triplet hole spin qubit planar Ge.” 2021. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:9323\">10.15479/AT:ISTA:9323</a>","chicago":"Jirovec, Daniel. “Research Data for ‘A Singlet-Triplet Hole Spin Qubit Planar Ge.’” Institute of Science and Technology Austria, 2021. <a href=\"https://doi.org/10.15479/AT:ISTA:9323\">https://doi.org/10.15479/AT:ISTA:9323</a>.","ieee":"D. Jirovec, “Research data for ‘A singlet-triplet hole spin qubit planar Ge.’” Institute of Science and Technology Austria, 2021.","mla":"Jirovec, Daniel. <i>Research Data for “A Singlet-Triplet Hole Spin Qubit Planar Ge.”</i> Institute of Science and Technology Austria, 2021, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:9323\">10.15479/AT:ISTA:9323</a>.","short":"D. Jirovec, (2021)."},"oa_version":"Published Version","contributor":[{"contributor_type":"project_member","id":"4C473F58-F248-11E8-B48F-1D18A9856A87","last_name":"Jirovec","first_name":"Daniel"}],"date_published":"2021-04-14T00:00:00Z","publisher":"Institute of Science and Technology Austria","file_date_updated":"2021-04-14T09:49:30Z","article_processing_charge":"No","title":"Research data for \"A singlet-triplet hole spin qubit planar Ge\"","abstract":[{"text":"This .zip File contains the data for figures presented in the main text and supplementary material of \"A singlet triplet hole spin qubit in planar Ge\" by D. Jirovec, et. al. The measurements were done using Labber Software and the data is stored in the hdf5 file format. The files can be opened using either the Labber Log Browser (https://labber.org/overview/) or Labber Python API (http://labber.org/online-doc/api/LogFile.html). A single file is acquired with QCodes and features the corresponding data type. XRD data are in .dat format and a code to open the data is provided. The code for simulations is as well provided in Python.","lang":"eng"}],"has_accepted_license":"1","month":"04","ddc":["530"],"file":[{"success":1,"relation":"main_file","file_size":221832287,"access_level":"open_access","creator":"djirovec","file_id":"9324","checksum":"c569d2a2ce1694445cdbca19cf8ae023","date_updated":"2021-04-14T09:48:47Z","date_created":"2021-04-14T09:48:47Z","content_type":"application/x-zip-compressed","file_name":"DataRepositorySTqubit.zip"},{"access_level":"open_access","file_size":4323,"file_id":"9325","checksum":"845bdf87430718ad6aff47eda7b5fc92","creator":"djirovec","relation":"main_file","success":1,"file_name":"ReadMe","date_created":"2021-04-14T09:49:30Z","date_updated":"2021-04-14T09:49:30Z","content_type":"application/octet-stream"}],"license":"https://creativecommons.org/publicdomain/zero/1.0/","doi":"10.15479/AT:ISTA:9323","year":"2021","day":"14","status":"public","oa":1,"date_created":"2021-04-14T09:50:22Z","_id":"9323","type":"research_data","related_material":{"record":[{"id":"8909","relation":"used_in_publication","status":"public"}]}},{"author":[{"id":"4DD40360-F248-11E8-B48F-1D18A9856A87","full_name":"Sperl, Georg","last_name":"Sperl","first_name":"Georg"},{"full_name":"Narain, Rahul","last_name":"Narain","first_name":"Rahul"},{"id":"3C61F1D2-F248-11E8-B48F-1D18A9856A87","full_name":"Wojtan, Christopher J","last_name":"Wojtan","first_name":"Christopher J","orcid":"0000-0001-6646-5546"}],"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","tmp":{"legal_code_url":"https://opensource.org/licenses/MIT","short":"MIT","name":"The MIT License"},"gitlab_url":"https://git.ist.ac.at/gsperl/MADYPG","date_updated":"2023-08-10T14:24:36Z","department":[{"_id":"GradSch"},{"_id":"ChWo"}],"citation":{"ieee":"G. Sperl, R. Narain, and C. Wojtan, “Mechanics-Aware Deformation of Yarn Pattern Geometry (Additional Animation/Model Data).” IST Austria, 2021.","chicago":"Sperl, Georg, Rahul Narain, and Chris Wojtan. “Mechanics-Aware Deformation of Yarn Pattern Geometry (Additional Animation/Model Data).” IST Austria, 2021. <a href=\"https://doi.org/10.15479/AT:ISTA:9327\">https://doi.org/10.15479/AT:ISTA:9327</a>.","ista":"Sperl G, Narain R, Wojtan C. 2021. Mechanics-Aware Deformation of Yarn Pattern Geometry (Additional Animation/Model Data), IST Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:9327\">10.15479/AT:ISTA:9327</a>.","ama":"Sperl G, Narain R, Wojtan C. Mechanics-Aware Deformation of Yarn Pattern Geometry (Additional Animation/Model Data). 2021. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:9327\">10.15479/AT:ISTA:9327</a>","apa":"Sperl, G., Narain, R., &#38; Wojtan, C. (2021). Mechanics-Aware Deformation of Yarn Pattern Geometry (Additional Animation/Model Data). IST Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:9327\">https://doi.org/10.15479/AT:ISTA:9327</a>","short":"G. Sperl, R. Narain, C. Wojtan, (2021).","mla":"Sperl, Georg, et al. <i>Mechanics-Aware Deformation of Yarn Pattern Geometry (Additional Animation/Model Data)</i>. IST Austria, 2021, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:9327\">10.15479/AT:ISTA:9327</a>."},"file_date_updated":"2021-04-26T09:33:44Z","publisher":"IST Austria","date_published":"2021-05-01T00:00:00Z","title":"Mechanics-Aware Deformation of Yarn Pattern Geometry (Additional Animation/Model Data)","abstract":[{"text":"This archive contains the missing sweater mesh animations and displacement models for the code of \"Mechanics-Aware Deformation of Yarn Pattern Geometry\"\r\n\r\nCode Repository: https://git.ist.ac.at/gsperl/MADYPG","lang":"eng"}],"has_accepted_license":"1","month":"05","file":[{"relation":"main_file","success":1,"file_id":"9328","checksum":"0324cb519273371708743f3282e7c081","creator":"gsperl","access_level":"open_access","file_size":802586232,"content_type":"application/zip","date_created":"2021-04-16T14:15:12Z","date_updated":"2021-04-16T14:15:12Z","file_name":"MADYPG_extra_data.zip"},{"file_name":"MADYPG.zip","content_type":"application/gzip","date_updated":"2021-04-26T09:33:44Z","date_created":"2021-04-26T09:33:44Z","creator":"pub-gitlab-bot","checksum":"4c224551adf852b136ec21a4e13f0c1b","file_id":"9353","file_size":64962865,"access_level":"open_access","relation":"main_file"}],"ddc":["005"],"gitlab_commit_id":"6a77e7e22769230ae5f5edaa090fb4b828e57573","status":"public","license":"https://opensource.org/licenses/MIT","doi":"10.15479/AT:ISTA:9327","year":"2021","date_created":"2021-04-16T14:26:19Z","oa":1,"type":"software","_id":"9327","related_material":{"record":[{"status":"public","id":"9818","relation":"used_for_analysis_in"}]}},{"date_created":"2021-04-18T22:01:39Z","type":"journal_article","_id":"9329","article_type":"original","status":"public","publication_identifier":{"eissn":["1872-678X"],"issn":["0165-0270"]},"ec_funded":1,"project":[{"_id":"25B7EB9E-B435-11E9-9278-68D0E5697425","grant_number":"692692","name":"Biophysics and circuit function of a giant cortical glumatergic synapse","call_identifier":"H2020"},{"grant_number":"Z00312","_id":"25C5A090-B435-11E9-9278-68D0E5697425","name":"The Wittgenstein Prize","call_identifier":"FWF"}],"quality_controlled":"1","oa_version":"Published Version","author":[{"first_name":"Xiaomin","last_name":"Zhang","id":"423EC9C2-F248-11E8-B48F-1D18A9856A87","full_name":"Zhang, Xiaomin"},{"first_name":"Alois","last_name":"Schlögl","orcid":"0000-0002-5621-8100","id":"45BF87EE-F248-11E8-B48F-1D18A9856A87","full_name":"Schlögl, Alois"},{"first_name":"David H","last_name":"Vandael","orcid":"0000-0001-7577-1676","id":"3AE48E0A-F248-11E8-B48F-1D18A9856A87","full_name":"Vandael, David H"},{"orcid":"0000-0001-5001-4804","last_name":"Jonas","first_name":"Peter M","full_name":"Jonas, Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87"}],"month":"03","has_accepted_license":"1","issue":"6","file":[{"success":1,"relation":"main_file","checksum":"2a5800d91b96d08b525e17319dcd5e44","file_id":"9339","creator":"dernst","access_level":"open_access","file_size":6924738,"content_type":"application/pdf","date_created":"2021-04-19T08:30:22Z","date_updated":"2021-04-19T08:30:22Z","file_name":"2021_JourNeuroscienceMeth_Zhang.pdf"}],"article_number":"109125","language":[{"iso":"eng"}],"article_processing_charge":"Yes (via OA deal)","acknowledged_ssus":[{"_id":"SSU"}],"volume":357,"oa":1,"acknowledgement":"This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement number 692692 to P.J.) and the Fond zur Förderung der Wissenschaftlichen Forschung (Z 312-B27, Wittgenstein award to P.J.). We thank Drs. Jozsef Csicsvari, Christoph Lampert, and Federico Stella for critically reading previous manuscript versions. We are also grateful to Drs. Josh Merel and Ben Shababo for their help with applying the Bayesian detection method to our data. We also thank Florian Marr for technical assistance, Eleftheria Kralli-Beller for manuscript editing, and the Scientific Service Units of IST Austria for efficient support.","day":"09","year":"2021","doi":"10.1016/j.jneumeth.2021.109125","scopus_import":"1","intvolume":"       357","publication":"Journal of Neuroscience Methods","date_updated":"2023-08-07T14:36:14Z","department":[{"_id":"PeJo"},{"_id":"ScienComp"}],"citation":{"short":"X. Zhang, A. Schlögl, D.H. Vandael, P.M. Jonas, Journal of Neuroscience Methods 357 (2021).","mla":"Zhang, Xiaomin, et al. “MOD: A Novel Machine-Learning Optimal-Filtering Method for Accurate and Efficient Detection of Subthreshold Synaptic Events in Vivo.” <i>Journal of Neuroscience Methods</i>, vol. 357, no. 6, 109125, Elsevier, 2021, doi:<a href=\"https://doi.org/10.1016/j.jneumeth.2021.109125\">10.1016/j.jneumeth.2021.109125</a>.","ieee":"X. Zhang, A. Schlögl, D. H. Vandael, and P. M. Jonas, “MOD: A novel machine-learning optimal-filtering method for accurate and efficient detection of subthreshold synaptic events in vivo,” <i>Journal of Neuroscience Methods</i>, vol. 357, no. 6. Elsevier, 2021.","chicago":"Zhang, Xiaomin, Alois Schlögl, David H Vandael, and Peter M Jonas. “MOD: A Novel Machine-Learning Optimal-Filtering Method for Accurate and Efficient Detection of Subthreshold Synaptic Events in Vivo.” <i>Journal of Neuroscience Methods</i>. Elsevier, 2021. <a href=\"https://doi.org/10.1016/j.jneumeth.2021.109125\">https://doi.org/10.1016/j.jneumeth.2021.109125</a>.","ista":"Zhang X, Schlögl A, Vandael DH, Jonas PM. 2021. MOD: A novel machine-learning optimal-filtering method for accurate and efficient detection of subthreshold synaptic events in vivo. Journal of Neuroscience Methods. 357(6), 109125.","ama":"Zhang X, Schlögl A, Vandael DH, Jonas PM. MOD: A novel machine-learning optimal-filtering method for accurate and efficient detection of subthreshold synaptic events in vivo. <i>Journal of Neuroscience Methods</i>. 2021;357(6). doi:<a href=\"https://doi.org/10.1016/j.jneumeth.2021.109125\">10.1016/j.jneumeth.2021.109125</a>","apa":"Zhang, X., Schlögl, A., Vandael, D. H., &#38; Jonas, P. M. (2021). MOD: A novel machine-learning optimal-filtering method for accurate and efficient detection of subthreshold synaptic events in vivo. <i>Journal of Neuroscience Methods</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.jneumeth.2021.109125\">https://doi.org/10.1016/j.jneumeth.2021.109125</a>"},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)"},"external_id":{"isi":["000661088500005"]},"abstract":[{"text":"Background: To understand information coding in single neurons, it is necessary to analyze subthreshold synaptic events, action potentials (APs), and their interrelation in different behavioral states. However, detecting excitatory postsynaptic potentials (EPSPs) or currents (EPSCs) in behaving animals remains challenging, because of unfavorable signal-to-noise ratio, high frequency, fluctuating amplitude, and variable time course of synaptic events.\r\nNew method: We developed a method for synaptic event detection, termed MOD (Machine-learning Optimal-filtering Detection-procedure), which combines concepts of supervised machine learning and optimal Wiener filtering. Experts were asked to manually score short epochs of data. The algorithm was trained to obtain the optimal filter coefficients of a Wiener filter and the optimal detection threshold. Scored and unscored data were then processed with the optimal filter, and events were detected as peaks above threshold.\r\nResults: We challenged MOD with EPSP traces in vivo in mice during spatial navigation and EPSC traces in vitro in slices under conditions of enhanced transmitter release. The area under the curve (AUC) of the receiver operating characteristics (ROC) curve was, on average, 0.894 for in vivo and 0.969 for in vitro data sets, indicating high detection accuracy and efficiency.\r\nComparison with existing methods: When benchmarked using a (1 − AUC)−1 metric, MOD outperformed previous methods (template-fit, deconvolution, and Bayesian methods) by an average factor of 3.13 for in vivo data sets, but showed comparable (template-fit, deconvolution) or higher (Bayesian) computational efficacy.\r\nConclusions: MOD may become an important new tool for large-scale, real-time analysis of synaptic activity.","lang":"eng"}],"publication_status":"published","isi":1,"ddc":["570"],"file_date_updated":"2021-04-19T08:30:22Z","date_published":"2021-03-09T00:00:00Z","publisher":"Elsevier","title":"MOD: A novel machine-learning optimal-filtering method for accurate and efficient detection of subthreshold synaptic events in vivo"},{"acknowledgement":"We thank Arnold Schwartz for providing α2δ-1 knockout mice; Ariane Benedetti, Sabine Baumgartner, Sandra Demetz, and Irene Mahlknecht for technical support; Nadine Ortner and Andreas Lieb for electrophysiological experiments; the team of the Electron Microscopy Facility at the Institute of Science and Technology Austria for technical support related to ultrastructural analysis; Hermann Dietrich and Anja Beierfuß and her team for animal care; Jutta Engel and Jörg Striessnig for critical discussions; and Bruno Benedetti and Bernhard Flucher for critical discussions and reading the manuscript. This study was supported by Austrian Science Fund Grants P24079, F44060, F44150, and DOC30-B30 (to G.J.O.) and T855 (to M.C.), European Research Council Grant AdG 694539 (to R.S.), Deutsche Forschungsgemeinschaft\r\nGrant SFB1348-TP A03 (to M.M.), and Interdisziplinäre Zentrum für Klinische Forschung Münster Grant Mi3/004/19 (to M.M.). This work is part of the PhD theses of C.L.S., S.M.G., and C.A.","doi":"10.1073/pnas.1920827118","day":"06","year":"2021","oa":1,"intvolume":"       118","publication":"PNAS","scopus_import":"1","external_id":{"isi":["000637398300002"]},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","department":[{"_id":"EM-Fac"},{"_id":"RySh"}],"date_updated":"2023-08-08T13:08:47Z","citation":{"short":"C.L. Schöpf, C. Ablinger, S.M. Geisler, R.I. Stanika, M. Campiglio, W. Kaufmann, B. Nimmervoll, B. Schlick, J. Brockhaus, M. Missler, R. Shigemoto, G.J. Obermair, PNAS 118 (2021).","mla":"Schöpf, Clemens L., et al. “Presynaptic Α2δ Subunits Are Key Organizers of Glutamatergic Synapses.” <i>PNAS</i>, vol. 118, no. 14, National Academy of Sciences, 2021, doi:<a href=\"https://doi.org/10.1073/pnas.1920827118\">10.1073/pnas.1920827118</a>.","chicago":"Schöpf, Clemens L., Cornelia Ablinger, Stefanie M. Geisler, Ruslan I. Stanika, Marta Campiglio, Walter Kaufmann, Benedikt Nimmervoll, et al. “Presynaptic Α2δ Subunits Are Key Organizers of Glutamatergic Synapses.” <i>PNAS</i>. National Academy of Sciences, 2021. <a href=\"https://doi.org/10.1073/pnas.1920827118\">https://doi.org/10.1073/pnas.1920827118</a>.","ama":"Schöpf CL, Ablinger C, Geisler SM, et al. Presynaptic α2δ subunits are key organizers of glutamatergic synapses. <i>PNAS</i>. 2021;118(14). doi:<a href=\"https://doi.org/10.1073/pnas.1920827118\">10.1073/pnas.1920827118</a>","ista":"Schöpf CL, Ablinger C, Geisler SM, Stanika RI, Campiglio M, Kaufmann W, Nimmervoll B, Schlick B, Brockhaus J, Missler M, Shigemoto R, Obermair GJ. 2021. Presynaptic α2δ subunits are key organizers of glutamatergic synapses. PNAS. 118(14).","apa":"Schöpf, C. L., Ablinger, C., Geisler, S. M., Stanika, R. I., Campiglio, M., Kaufmann, W., … Obermair, G. J. (2021). Presynaptic α2δ subunits are key organizers of glutamatergic synapses. <i>PNAS</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.1920827118\">https://doi.org/10.1073/pnas.1920827118</a>","ieee":"C. L. Schöpf <i>et al.</i>, “Presynaptic α2δ subunits are key organizers of glutamatergic synapses,” <i>PNAS</i>, vol. 118, no. 14. National Academy of Sciences, 2021."},"publisher":"National Academy of Sciences","date_published":"2021-04-06T00:00:00Z","file_date_updated":"2021-04-19T10:10:56Z","title":"Presynaptic α2δ subunits are key organizers of glutamatergic synapses","publication_status":"published","abstract":[{"lang":"eng","text":"In nerve cells the genes encoding for α2δ subunits of voltage-gated calcium channels have been linked to synaptic functions and neurological disease. Here we show that α2δ subunits are essential for the formation and organization of glutamatergic synapses. Using a cellular α2δ subunit triple-knockout/knockdown model, we demonstrate a failure in presynaptic differentiation evidenced by defective presynaptic calcium channel clustering and calcium influx, smaller presynaptic active zones, and a strongly reduced accumulation of presynaptic vesicle-associated proteins (synapsin and vGLUT). The presynaptic defect is associated with the downscaling of postsynaptic AMPA receptors and the postsynaptic density. The role of α2δ isoforms as synaptic organizers is highly redundant, as each individual α2δ isoform can rescue presynaptic calcium channel trafficking and expression of synaptic proteins. Moreover, α2δ-2 and α2δ-3 with mutated metal ion-dependent adhesion sites can fully rescue presynaptic synapsin expression but only partially calcium channel trafficking, suggesting that the regulatory role of α2δ subunits is independent from its role as a calcium channel subunit. Our findings influence the current view on excitatory synapse formation. First, our study suggests that postsynaptic differentiation is secondary to presynaptic differentiation. Second, the dependence of presynaptic differentiation on α2δ implicates α2δ subunits as potential nucleation points for the organization of synapses. Finally, our results suggest that α2δ subunits act as transsynaptic organizers of glutamatergic synapses, thereby aligning the synaptic active zone with the postsynaptic density."}],"isi":1,"ddc":["570"],"status":"public","publication_identifier":{"eissn":["1091-6490"]},"date_created":"2021-04-18T22:01:40Z","article_type":"original","_id":"9330","type":"journal_article","ec_funded":1,"author":[{"full_name":"Schöpf, Clemens L.","first_name":"Clemens L.","last_name":"Schöpf"},{"first_name":"Cornelia","last_name":"Ablinger","full_name":"Ablinger, Cornelia"},{"full_name":"Geisler, Stefanie M.","first_name":"Stefanie M.","last_name":"Geisler"},{"full_name":"Stanika, Ruslan I.","last_name":"Stanika","first_name":"Ruslan I."},{"full_name":"Campiglio, Marta","first_name":"Marta","last_name":"Campiglio"},{"id":"3F99E422-F248-11E8-B48F-1D18A9856A87","full_name":"Kaufmann, Walter","first_name":"Walter","last_name":"Kaufmann","orcid":"0000-0001-9735-5315"},{"first_name":"Benedikt","last_name":"Nimmervoll","full_name":"Nimmervoll, Benedikt"},{"full_name":"Schlick, Bettina","first_name":"Bettina","last_name":"Schlick"},{"last_name":"Brockhaus","first_name":"Johannes","full_name":"Brockhaus, Johannes"},{"last_name":"Missler","first_name":"Markus","full_name":"Missler, Markus"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi","last_name":"Shigemoto","first_name":"Ryuichi","orcid":"0000-0001-8761-9444"},{"last_name":"Obermair","first_name":"Gerald J.","full_name":"Obermair, Gerald J."}],"quality_controlled":"1","project":[{"call_identifier":"H2020","_id":"25CA28EA-B435-11E9-9278-68D0E5697425","grant_number":"694539","name":"In situ analysis of single channel subunit composition in neurons: physiological implication in synaptic plasticity and behaviour"}],"oa_version":"Published Version","language":[{"iso":"eng"}],"volume":118,"acknowledged_ssus":[{"_id":"EM-Fac"}],"article_processing_charge":"No","month":"04","has_accepted_license":"1","file":[{"file_name":"2021_PNAS_Schoepf.pdf","date_created":"2021-04-19T10:10:56Z","date_updated":"2021-04-19T10:10:56Z","content_type":"application/pdf","access_level":"open_access","file_size":2603911,"file_id":"9340","checksum":"dd014f68ae9d7d8d8fc4139a24e04506","creator":"dernst","success":1,"relation":"main_file"}],"issue":"14"},{"quality_controlled":"1","oa_version":"Preprint","author":[{"last_name":"Szigeti","first_name":"Stuart S.","full_name":"Szigeti, Stuart S."},{"orcid":"0000-0002-2031-204X","first_name":"Onur","last_name":"Hosten","full_name":"Hosten, Onur","id":"4C02D85E-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Haine","first_name":"Simon A.","full_name":"Haine, Simon A."}],"month":"04","issue":"14","article_number":"140501","language":[{"iso":"eng"}],"article_processing_charge":"No","volume":118,"date_created":"2021-04-18T22:01:40Z","type":"journal_article","_id":"9331","article_type":"original","main_file_link":[{"url":"https://arxiv.org/abs/2010.09168","open_access":"1"}],"publication_identifier":{"issn":["00036951"]},"status":"public","date_updated":"2023-08-07T14:36:42Z","department":[{"_id":"OnHo"}],"citation":{"short":"S.S. Szigeti, O. Hosten, S.A. Haine, Applied Physics Letters 118 (2021).","mla":"Szigeti, Stuart S., et al. “Improving Cold-Atom Sensors with Quantum Entanglement: Prospects and Challenges.” <i>Applied Physics Letters</i>, vol. 118, no. 14, 140501, AIP Publishing, 2021, doi:<a href=\"https://doi.org/10.1063/5.0050235\">10.1063/5.0050235</a>.","ieee":"S. S. Szigeti, O. Hosten, and S. A. Haine, “Improving cold-atom sensors with quantum entanglement: Prospects and challenges,” <i>Applied Physics Letters</i>, vol. 118, no. 14. AIP Publishing, 2021.","ista":"Szigeti SS, Hosten O, Haine SA. 2021. Improving cold-atom sensors with quantum entanglement: Prospects and challenges. Applied Physics Letters. 118(14), 140501.","ama":"Szigeti SS, Hosten O, Haine SA. Improving cold-atom sensors with quantum entanglement: Prospects and challenges. <i>Applied Physics Letters</i>. 2021;118(14). doi:<a href=\"https://doi.org/10.1063/5.0050235\">10.1063/5.0050235</a>","chicago":"Szigeti, Stuart S., Onur Hosten, and Simon A. Haine. “Improving Cold-Atom Sensors with Quantum Entanglement: Prospects and Challenges.” <i>Applied Physics Letters</i>. AIP Publishing, 2021. <a href=\"https://doi.org/10.1063/5.0050235\">https://doi.org/10.1063/5.0050235</a>.","apa":"Szigeti, S. S., Hosten, O., &#38; Haine, S. A. (2021). Improving cold-atom sensors with quantum entanglement: Prospects and challenges. <i>Applied Physics Letters</i>. AIP Publishing. <a href=\"https://doi.org/10.1063/5.0050235\">https://doi.org/10.1063/5.0050235</a>"},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","external_id":{"isi":["000637702100001"],"arxiv":["2010.09168"]},"abstract":[{"lang":"eng","text":"Quantum entanglement has been generated and verified in cold-atom experiments and used to make atom-interferometric measurements below the shot-noise limit. However, current state-of-the-art cold-atom devices exploit separable (i.e., unentangled) atomic states. This perspective piece asks the question: can entanglement usefully improve cold-atom sensors, in the sense that it gives new sensing capabilities unachievable with current state-of-the-art devices? We briefly review the state-of-the-art in precision cold-atom sensing, focusing on clocks and inertial sensors, identifying the potential benefits entanglement could bring to these devices, and the challenges that need to be overcome to realize these benefits. We survey demonstrated methods of generating metrologically useful entanglement in cold-atom systems, note their relative strengths and weaknesses, and assess their prospects for near-to-medium term quantum-enhanced cold-atom sensing."}],"publication_status":"published","isi":1,"date_published":"2021-04-07T00:00:00Z","publisher":"AIP Publishing","title":"Improving cold-atom sensors with quantum entanglement: Prospects and challenges","oa":1,"acknowledgement":"We acknowledge fruitful discussions with John Close, Chris Freier, Kyle Hardman, Joseph Hope, and Paul Wigley, and insightful suggestions made by Franck Pereira dos Santos on behalf of the Atom Interferometry and Inertial Sensors team at SYRTE. S.S.S. was supported by an Australian Research Council Discovery Early Career Researcher Award (DECRA), Project No. DE200100495. O.H. was supported by IST Austria.","year":"2021","day":"07","doi":"10.1063/5.0050235","scopus_import":"1","intvolume":"       118","arxiv":1,"publication":"Applied Physics Letters"},{"intvolume":"        22","publication":"International Journal of Molecular Sciences","scopus_import":"1","acknowledgement":"This research was supported by a postdoctoral fellowship of the Carl Tryggers Foundation (to K.Ö.) and by grants from Vetenskapsrådet (Nr.: 621-2004-2921 to L.B.) and VINNOVA (to L.B. and S.R.).\r\nWe thank Frederic Berger, Hidehiro Fukaki, Malcolm Bennett, Claudia Köhler, Jiri Friml for providing pRBR1::RBR1-RFP, ssl2-1, slr-1, pPKL::PKL-GFP seeds and the DR5 expressing vector, respectively. Authors are grateful to Hayashi Kenichiro for providing the auxinol compound and to Rishi Bhalerao for stimulating discussions. The technical help of Adeline Rigal and Thomas Vain with the auxinol experiments is much appreciated.","doi":"10.3390/ijms22083862","year":"2021","day":"08","oa":1,"file_date_updated":"2021-04-19T10:54:55Z","date_published":"2021-04-08T00:00:00Z","publisher":"MDPI","title":"Pickle recruits retinoblastoma related 1 to control lateral root formation in arabidopsis","publication_status":"published","abstract":[{"text":"Lateral root (LR) formation is an example of a plant post-embryonic organogenesis event. LRs are issued from non-dividing cells entering consecutive steps of formative divisions, proliferation and elongation. The chromatin remodeling protein PICKLE (PKL) negatively regulates auxin-mediated LR formation through a mechanism that is not yet known. Here we show that PKL interacts with RETINOBLASTOMA-RELATED 1 (RBR1) to repress the LATERAL ORGAN BOUNDARIES-DOMAIN 16 (LBD16) promoter activity. Since LBD16 function is required for the formative division of LR founder cells, repression mediated by the PKL–RBR1 complex negatively regulates formative division and LR formation. Inhibition of LR formation by PKL–RBR1 is counteracted by auxin, indicating that, in addition to auxin-mediated transcriptional responses, the fine-tuned process of LR formation is also controlled at the chromatin level in an auxin-signaling dependent manner.","lang":"eng"}],"isi":1,"ddc":["570"],"external_id":{"isi":["000644394800001"]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"department":[{"_id":"EvBe"}],"date_updated":"2023-08-08T13:09:58Z","citation":{"ieee":"K. Ötvös <i>et al.</i>, “Pickle recruits retinoblastoma related 1 to control lateral root formation in arabidopsis,” <i>International Journal of Molecular Sciences</i>, vol. 22, no. 8. MDPI, 2021.","apa":"Ötvös, K., Miskolczi, P., Marhavý, P., Cruz-Ramírez, A., Benková, E., Robert, S., &#38; Bakó, L. (2021). Pickle recruits retinoblastoma related 1 to control lateral root formation in arabidopsis. <i>International Journal of Molecular Sciences</i>. MDPI. <a href=\"https://doi.org/10.3390/ijms22083862\">https://doi.org/10.3390/ijms22083862</a>","ista":"Ötvös K, Miskolczi P, Marhavý P, Cruz-Ramírez A, Benková E, Robert S, Bakó L. 2021. Pickle recruits retinoblastoma related 1 to control lateral root formation in arabidopsis. International Journal of Molecular Sciences. 22(8), 3862.","chicago":"Ötvös, Krisztina, Pál Miskolczi, Peter Marhavý, Alfredo Cruz-Ramírez, Eva Benková, Stéphanie Robert, and László Bakó. “Pickle Recruits Retinoblastoma Related 1 to Control Lateral Root Formation in Arabidopsis.” <i>International Journal of Molecular Sciences</i>. MDPI, 2021. <a href=\"https://doi.org/10.3390/ijms22083862\">https://doi.org/10.3390/ijms22083862</a>.","ama":"Ötvös K, Miskolczi P, Marhavý P, et al. Pickle recruits retinoblastoma related 1 to control lateral root formation in arabidopsis. <i>International Journal of Molecular Sciences</i>. 2021;22(8). doi:<a href=\"https://doi.org/10.3390/ijms22083862\">10.3390/ijms22083862</a>","short":"K. Ötvös, P. Miskolczi, P. Marhavý, A. Cruz-Ramírez, E. Benková, S. Robert, L. Bakó, International Journal of Molecular Sciences 22 (2021).","mla":"Ötvös, Krisztina, et al. “Pickle Recruits Retinoblastoma Related 1 to Control Lateral Root Formation in Arabidopsis.” <i>International Journal of Molecular Sciences</i>, vol. 22, no. 8, 3862, MDPI, 2021, doi:<a href=\"https://doi.org/10.3390/ijms22083862\">10.3390/ijms22083862</a>."},"status":"public","publication_identifier":{"issn":["1661-6596"],"eissn":["1422-0067"]},"date_created":"2021-04-18T22:01:41Z","article_type":"original","type":"journal_article","_id":"9332","language":[{"iso":"eng"}],"volume":22,"article_processing_charge":"No","month":"04","has_accepted_license":"1","file":[{"file_name":"2021_JourMolecularScience_Oetvoes.pdf","content_type":"application/pdf","date_created":"2021-04-19T10:54:55Z","date_updated":"2021-04-19T10:54:55Z","file_id":"9342","checksum":"26ada2531ad1f9c01a1664de0431f1fe","creator":"dernst","access_level":"open_access","file_size":2769717,"success":1,"relation":"main_file"}],"article_number":"3862","issue":"8","author":[{"id":"29B901B0-F248-11E8-B48F-1D18A9856A87","full_name":"Ötvös, Krisztina","first_name":"Krisztina","last_name":"Ötvös","orcid":"0000-0002-5503-4983"},{"full_name":"Miskolczi, Pál","first_name":"Pál","last_name":"Miskolczi"},{"last_name":"Marhavý","first_name":"Peter","orcid":"0000-0001-5227-5741","id":"3F45B078-F248-11E8-B48F-1D18A9856A87","full_name":"Marhavý, Peter"},{"full_name":"Cruz-Ramírez, Alfredo","first_name":"Alfredo","last_name":"Cruz-Ramírez"},{"first_name":"Eva","last_name":"Benková","orcid":"0000-0002-8510-9739","id":"38F4F166-F248-11E8-B48F-1D18A9856A87","full_name":"Benková, Eva"},{"first_name":"Stéphanie","last_name":"Robert","full_name":"Robert, Stéphanie"},{"full_name":"Bakó, László","first_name":"László","last_name":"Bakó"}],"quality_controlled":"1","oa_version":"Published Version"},{"day":"05","year":"2021","doi":"10.1007/s11005-021-01380-7","acknowledgement":"I thank Marcel Griesemer for many interesting discussions about the Fröhlich polaron and also for valuable comments on this manuscript. Helpful discussions with Nikolai Leopold and Robert Seiringer are also gratefully acknowledged. This work was partially supported by the Deutsche Forschungsgemeinschaft (DFG) through the Research Training Group 1838: Spectral Theory and Dynamics of Quantum Systems. Open Access funding enabled and organized by Projekt DEAL.","oa":1,"publication":"Letters in Mathematical Physics","intvolume":"       111","scopus_import":"1","external_id":{"isi":["000637359300002"]},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","citation":{"short":"D.J. Mitrouskas, Letters in Mathematical Physics 111 (2021).","mla":"Mitrouskas, David Johannes. “A Note on the Fröhlich Dynamics in the Strong Coupling Limit.” <i>Letters in Mathematical Physics</i>, vol. 111, 45, Springer Nature, 2021, doi:<a href=\"https://doi.org/10.1007/s11005-021-01380-7\">10.1007/s11005-021-01380-7</a>.","ista":"Mitrouskas DJ. 2021. A note on the Fröhlich dynamics in the strong coupling limit. Letters in Mathematical Physics. 111, 45.","chicago":"Mitrouskas, David Johannes. “A Note on the Fröhlich Dynamics in the Strong Coupling Limit.” <i>Letters in Mathematical Physics</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1007/s11005-021-01380-7\">https://doi.org/10.1007/s11005-021-01380-7</a>.","ama":"Mitrouskas DJ. A note on the Fröhlich dynamics in the strong coupling limit. <i>Letters in Mathematical Physics</i>. 2021;111. doi:<a href=\"https://doi.org/10.1007/s11005-021-01380-7\">10.1007/s11005-021-01380-7</a>","apa":"Mitrouskas, D. J. (2021). A note on the Fröhlich dynamics in the strong coupling limit. <i>Letters in Mathematical Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s11005-021-01380-7\">https://doi.org/10.1007/s11005-021-01380-7</a>","ieee":"D. J. Mitrouskas, “A note on the Fröhlich dynamics in the strong coupling limit,” <i>Letters in Mathematical Physics</i>, vol. 111. Springer Nature, 2021."},"department":[{"_id":"RoSe"}],"date_updated":"2023-08-08T13:09:28Z","title":"A note on the Fröhlich dynamics in the strong coupling limit","file_date_updated":"2021-04-19T10:40:01Z","date_published":"2021-04-05T00:00:00Z","publisher":"Springer Nature","isi":1,"ddc":["510"],"publication_status":"published","abstract":[{"text":"We revise a previous result about the Fröhlich dynamics in the strong coupling limit obtained in Griesemer (Rev Math Phys 29(10):1750030, 2017). In the latter it was shown that the Fröhlich time evolution applied to the initial state φ0⊗ξα, where φ0 is the electron ground state of the Pekar energy functional and ξα the associated coherent state of the phonons, can be approximated by a global phase for times small compared to α2. In the present note we prove that a similar approximation holds for t=O(α2) if one includes a nontrivial effective dynamics for the phonons that is generated by an operator proportional to α−2 and quadratic in creation and annihilation operators. Our result implies that the electron ground state remains close to its initial state for times of order α2, while the phonon fluctuations around the coherent state ξα can be described by a time-dependent Bogoliubov transformation.","lang":"eng"}],"publication_identifier":{"issn":["03779017"],"eissn":["15730530"]},"status":"public","article_type":"original","_id":"9333","type":"journal_article","date_created":"2021-04-18T22:01:41Z","author":[{"last_name":"Mitrouskas","first_name":"David Johannes","full_name":"Mitrouskas, David Johannes","id":"cbddacee-2b11-11eb-a02e-a2e14d04e52d"}],"oa_version":"Published Version","quality_controlled":"1","volume":111,"article_processing_charge":"No","language":[{"iso":"eng"}],"file":[{"file_name":"2021_LettersMathPhysics_Mitrouskas.pdf","content_type":"application/pdf","date_updated":"2021-04-19T10:40:01Z","date_created":"2021-04-19T10:40:01Z","creator":"dernst","file_id":"9341","checksum":"be56c0845a43c0c5c772ee0b5053f7d7","file_size":438084,"access_level":"open_access","success":1,"relation":"main_file"}],"article_number":"45","month":"04","has_accepted_license":"1"},{"date_updated":"2023-08-08T13:11:31Z","department":[{"_id":"NanoFab"}],"citation":{"apa":"Duan, J., Álvarez-Pérez, G., Voronin, K. V., Prieto Gonzalez, I., Taboada-Gutiérrez, J., Volkov, V. S., … Alonso-González, P. (2021). Enabling propagation of anisotropic polaritons along forbidden directions via a topological transition. <i>Science Advances</i>. AAAS. <a href=\"https://doi.org/10.1126/sciadv.abf2690\">https://doi.org/10.1126/sciadv.abf2690</a>","ista":"Duan J, Álvarez-Pérez G, Voronin KV, Prieto Gonzalez I, Taboada-Gutiérrez J, Volkov VS, Martín-Sánchez J, Nikitin AY, Alonso-González P. 2021. Enabling propagation of anisotropic polaritons along forbidden directions via a topological transition. Science Advances. 7(14), eabf2690.","chicago":"Duan, J., G. Álvarez-Pérez, K. V. Voronin, Ivan Prieto Gonzalez, J. Taboada-Gutiérrez, V. S. Volkov, J. Martín-Sánchez, A. Y. Nikitin, and P. Alonso-González. “Enabling Propagation of Anisotropic Polaritons along Forbidden Directions via a Topological Transition.” <i>Science Advances</i>. AAAS, 2021. <a href=\"https://doi.org/10.1126/sciadv.abf2690\">https://doi.org/10.1126/sciadv.abf2690</a>.","ama":"Duan J, Álvarez-Pérez G, Voronin KV, et al. Enabling propagation of anisotropic polaritons along forbidden directions via a topological transition. <i>Science Advances</i>. 2021;7(14). doi:<a href=\"https://doi.org/10.1126/sciadv.abf2690\">10.1126/sciadv.abf2690</a>","ieee":"J. Duan <i>et al.</i>, “Enabling propagation of anisotropic polaritons along forbidden directions via a topological transition,” <i>Science Advances</i>, vol. 7, no. 14. AAAS, 2021.","mla":"Duan, J., et al. “Enabling Propagation of Anisotropic Polaritons along Forbidden Directions via a Topological Transition.” <i>Science Advances</i>, vol. 7, no. 14, eabf2690, AAAS, 2021, doi:<a href=\"https://doi.org/10.1126/sciadv.abf2690\">10.1126/sciadv.abf2690</a>.","short":"J. Duan, G. Álvarez-Pérez, K.V. Voronin, I. Prieto Gonzalez, J. Taboada-Gutiérrez, V.S. Volkov, J. Martín-Sánchez, A.Y. Nikitin, P. Alonso-González, Science Advances 7 (2021)."},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","short":"CC BY-NC (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png"},"external_id":{"pmid":["33811076"],"isi":["000636455600027"]},"abstract":[{"lang":"eng","text":"Polaritons with directional in-plane propagation and ultralow losses in van der Waals (vdW) crystals promise unprecedented manipulation of light at the nanoscale. However, these polaritons present a crucial limitation: their directional propagation is intrinsically determined by the crystal structure of the host material, imposing forbidden directions of propagation. Here, we demonstrate that directional polaritons (in-plane hyperbolic phonon polaritons) in a vdW crystal (α-phase molybdenum trioxide) can be directed along forbidden directions by inducing an optical topological transition, which emerges when the slab is placed on a substrate with a given negative permittivity (4H–silicon carbide). By visualizing the transition in real space, we observe exotic polaritonic states between mutually orthogonal hyperbolic regimes, which unveil the topological origin of the transition: a gap opening in the dispersion. This work provides insights into optical topological transitions in vdW crystals, which introduce a route to direct light at the nanoscale."}],"publication_status":"published","isi":1,"ddc":["530"],"file_date_updated":"2021-04-19T11:17:29Z","publisher":"AAAS","date_published":"2021-04-02T00:00:00Z","pmid":1,"title":"Enabling propagation of anisotropic polaritons along forbidden directions via a topological transition","oa":1,"acknowledgement":"G.Á.-P. and J.T.-G. acknowledge support through the Severo Ochoa Program from the government of the Principality of Asturias (grant nos. PA20-PF-BP19-053 and PA-18-PF-BP17-126, respectively). K.V.V. and V.S.V. acknowledge the Ministry of Science and Higher Education of the Russian Federation (no. 0714-2020-0002). J. M.-S. acknowledges financial support through the Ramón y Cajal Program from the government of Spain and FSE (RYC2018-026196-I). A.Y.N. acknowledges the Spanish Ministry of Science, Innovation and Universities (national project no. MAT201788358-C3-3-R), and the Basque Department of Education (PIBA-2020-1-0014). P.A.-G. acknowledges support from the European Research Council under starting grant no. 715496, 2DNANOPTICA. ","day":"02","year":"2021","doi":"10.1126/sciadv.abf2690","scopus_import":"1","intvolume":"         7","publication":"Science Advances","quality_controlled":"1","oa_version":"Published Version","author":[{"full_name":"Duan, J.","last_name":"Duan","first_name":"J."},{"full_name":"Álvarez-Pérez, G.","first_name":"G.","last_name":"Álvarez-Pérez"},{"first_name":"K. V.","last_name":"Voronin","full_name":"Voronin, K. V."},{"id":"2A307FE2-F248-11E8-B48F-1D18A9856A87","full_name":"Prieto Gonzalez, Ivan","first_name":"Ivan","last_name":"Prieto Gonzalez","orcid":"0000-0002-7370-5357"},{"full_name":"Taboada-Gutiérrez, J.","last_name":"Taboada-Gutiérrez","first_name":"J."},{"full_name":"Volkov, V. S.","last_name":"Volkov","first_name":"V. S."},{"last_name":"Martín-Sánchez","first_name":"J.","full_name":"Martín-Sánchez, J."},{"last_name":"Nikitin","first_name":"A. Y.","full_name":"Nikitin, A. Y."},{"last_name":"Alonso-González","first_name":"P.","full_name":"Alonso-González, P."}],"has_accepted_license":"1","month":"04","issue":"14","article_number":"eabf2690","file":[{"file_name":"2021_ScienceAdv_Duan.pdf","date_created":"2021-04-19T11:17:29Z","date_updated":"2021-04-19T11:17:29Z","content_type":"application/pdf","access_level":"open_access","file_size":717489,"file_id":"9343","checksum":"4b383d4a1d484a71bbc64ecf401bbdbb","creator":"dernst","relation":"main_file","success":1}],"language":[{"iso":"eng"}],"article_processing_charge":"No","volume":7,"date_created":"2021-04-18T22:01:42Z","type":"journal_article","_id":"9334","article_type":"original","status":"public","publication_identifier":{"eissn":["23752548"]}},{"oa":1,"acknowledgement":"This research was supported by the DFG Collaborative Research Center TRR 109, “Discretization in Geometry and Dynamics”.","page":"60-87","year":"2021","doi":"10.1137/19M1300017","day":"01","scopus_import":"1","arxiv":1,"intvolume":"        59","publication":"SIAM Journal on Numerical Analysis","department":[{"_id":"JuFi"}],"date_updated":"2023-08-08T13:10:40Z","citation":{"mla":"Fischer, Julian L., and Daniel Matthes. “The Waiting Time Phenomenon in Spatially Discretized Porous Medium and Thin Film Equations.” <i>SIAM Journal on Numerical Analysis</i>, vol. 59, no. 1, Society for Industrial and Applied Mathematics, 2021, pp. 60–87, doi:<a href=\"https://doi.org/10.1137/19M1300017\">10.1137/19M1300017</a>.","short":"J.L. Fischer, D. Matthes, SIAM Journal on Numerical Analysis 59 (2021) 60–87.","apa":"Fischer, J. L., &#38; Matthes, D. (2021). The waiting time phenomenon in spatially discretized porous medium and thin film equations. <i>SIAM Journal on Numerical Analysis</i>. Society for Industrial and Applied Mathematics. <a href=\"https://doi.org/10.1137/19M1300017\">https://doi.org/10.1137/19M1300017</a>","ista":"Fischer JL, Matthes D. 2021. The waiting time phenomenon in spatially discretized porous medium and thin film equations. SIAM Journal on Numerical Analysis. 59(1), 60–87.","ama":"Fischer JL, Matthes D. The waiting time phenomenon in spatially discretized porous medium and thin film equations. <i>SIAM Journal on Numerical Analysis</i>. 2021;59(1):60-87. doi:<a href=\"https://doi.org/10.1137/19M1300017\">10.1137/19M1300017</a>","chicago":"Fischer, Julian L, and Daniel Matthes. “The Waiting Time Phenomenon in Spatially Discretized Porous Medium and Thin Film Equations.” <i>SIAM Journal on Numerical Analysis</i>. Society for Industrial and Applied Mathematics, 2021. <a href=\"https://doi.org/10.1137/19M1300017\">https://doi.org/10.1137/19M1300017</a>.","ieee":"J. L. Fischer and D. Matthes, “The waiting time phenomenon in spatially discretized porous medium and thin film equations,” <i>SIAM Journal on Numerical Analysis</i>, vol. 59, no. 1. Society for Industrial and Applied Mathematics, pp. 60–87, 2021."},"external_id":{"arxiv":["1911.04185"],"isi":["000625044600003"]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publication_status":"published","abstract":[{"text":"Various degenerate diffusion equations exhibit a waiting time phenomenon: depending on the “flatness” of the compactly supported initial datum at the boundary of the support, the support of the solution may not expand for a certain amount of time. We show that this phenomenon is captured by particular Lagrangian discretizations of the porous medium and the thin film equations, and we obtain sufficient criteria for the occurrence of waiting times that are consistent with the known ones for the original PDEs. For the spatially discrete solution, the waiting time phenomenon refers to a deviation of the edge of support from its original position by a quantity comparable to the mesh width, over a mesh-independent time interval. Our proof is based on estimates on the fluid velocity in Lagrangian coordinates. Combining weighted entropy estimates with an iteration technique à la Stampacchia leads to upper bounds on free boundary propagation. Numerical simulations show that the phenomenon is already clearly visible for relatively coarse discretizations.","lang":"eng"}],"isi":1,"date_published":"2021-01-01T00:00:00Z","publisher":"Society for Industrial and Applied Mathematics","title":"The waiting time phenomenon in spatially discretized porous medium and thin film equations","date_created":"2021-04-18T22:01:42Z","article_type":"original","type":"journal_article","_id":"9335","main_file_link":[{"url":"https://arxiv.org/abs/1911.04185","open_access":"1"}],"status":"public","publication_identifier":{"issn":["0036-1429"]},"quality_controlled":"1","oa_version":"Preprint","author":[{"last_name":"Fischer","first_name":"Julian L","orcid":"0000-0002-0479-558X","id":"2C12A0B0-F248-11E8-B48F-1D18A9856A87","full_name":"Fischer, Julian L"},{"full_name":"Matthes, Daniel","first_name":"Daniel","last_name":"Matthes"}],"month":"01","issue":"1","language":[{"iso":"eng"}],"volume":59,"article_processing_charge":"No"},{"oa":1,"year":"2021","day":"05","doi":"10.1111/febs.15823","acknowledgement":"The authors thank Nicholas Asby of the University of Chicago for valuable comments on an earlier version of this work. A.P.S. was partially supported by the NARSAD Young Investigator Grant 27705. S.J.H was supported by the National Institutes of Health grant R35GM133732.","scopus_import":"1","publication":"FEBS Journal","citation":{"ista":"Sarabipour S, Hainer SJ, Arslan FN, De Winde CM, Furlong E, Bielczyk N, Jadavji NM, Shah AP, Davla S. 2021. Building and sustaining mentor interactions as a mentee. FEBS Journal.","chicago":"Sarabipour, Sarvenaz, Sarah J. Hainer, Feyza N Arslan, Charlotte M. De Winde, Emily Furlong, Natalia Bielczyk, Nafisa M. Jadavji, Aparna P. Shah, and Sejal Davla. “Building and Sustaining Mentor Interactions as a Mentee.” <i>FEBS Journal</i>. Wiley, 2021. <a href=\"https://doi.org/10.1111/febs.15823\">https://doi.org/10.1111/febs.15823</a>.","ama":"Sarabipour S, Hainer SJ, Arslan FN, et al. Building and sustaining mentor interactions as a mentee. <i>FEBS Journal</i>. 2021. doi:<a href=\"https://doi.org/10.1111/febs.15823\">10.1111/febs.15823</a>","apa":"Sarabipour, S., Hainer, S. J., Arslan, F. N., De Winde, C. M., Furlong, E., Bielczyk, N., … Davla, S. (2021). Building and sustaining mentor interactions as a mentee. <i>FEBS Journal</i>. Wiley. <a href=\"https://doi.org/10.1111/febs.15823\">https://doi.org/10.1111/febs.15823</a>","ieee":"S. Sarabipour <i>et al.</i>, “Building and sustaining mentor interactions as a mentee,” <i>FEBS Journal</i>. Wiley, 2021.","short":"S. Sarabipour, S.J. Hainer, F.N. Arslan, C.M. De Winde, E. Furlong, N. Bielczyk, N.M. Jadavji, A.P. Shah, S. Davla, FEBS Journal (2021).","mla":"Sarabipour, Sarvenaz, et al. “Building and Sustaining Mentor Interactions as a Mentee.” <i>FEBS Journal</i>, Wiley, 2021, doi:<a href=\"https://doi.org/10.1111/febs.15823\">10.1111/febs.15823</a>."},"date_updated":"2023-08-08T13:12:55Z","department":[{"_id":"CaHe"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","external_id":{"isi":["000636678800001"],"pmid":["33818917"]},"alternative_title":["Words of Advice"],"isi":1,"abstract":[{"lang":"eng","text":"Mentorship is experience and/or knowledge‐based guidance. Mentors support, sponsor and advocate for mentees. Having one or more mentors when you seek advice can significantly influence and improve your research endeavours, well‐being and career development. Positive mentee–mentor relationships are vital for maintaining work–life balance and success in careers. Early‐career researchers (ECRs), in particular, can benefit from mentorship to navigate challenges in academic and nonacademic life and careers. Yet, strategies for selecting mentors and maintaining interactions with them are often underdiscussed within research environments. In this Words of Advice, we provide recommendations for ECRs to seek and manage mentorship interactions. Our article draws from our experiences as ECRs and published work, to provide suggestions for mentees to proactively promote beneficial mentorship interactions. The recommended practices highlight the importance of identifying mentorship needs, planning and selecting multiple and diverse mentors, setting goals, and maintaining constructive, and mutually beneficial working relationships with mentors."}],"publication_status":"published","title":"Building and sustaining mentor interactions as a mentee","date_published":"2021-04-05T00:00:00Z","publisher":"Wiley","pmid":1,"type":"journal_article","_id":"9336","article_type":"original","date_created":"2021-04-18T22:01:43Z","main_file_link":[{"url":"https://doi.org/10.1111/febs.15823","open_access":"1"}],"publication_identifier":{"eissn":["1742-4658"],"issn":["1742-464X"]},"status":"public","oa_version":"Published Version","quality_controlled":"1","author":[{"full_name":"Sarabipour, Sarvenaz","last_name":"Sarabipour","first_name":"Sarvenaz"},{"full_name":"Hainer, Sarah J.","last_name":"Hainer","first_name":"Sarah J."},{"id":"49DA7910-F248-11E8-B48F-1D18A9856A87","full_name":"Arslan, Feyza N","first_name":"Feyza N","last_name":"Arslan","orcid":"0000-0001-5809-9566"},{"full_name":"De Winde, Charlotte M.","first_name":"Charlotte M.","last_name":"De Winde"},{"last_name":"Furlong","first_name":"Emily","full_name":"Furlong, Emily"},{"first_name":"Natalia","last_name":"Bielczyk","full_name":"Bielczyk, Natalia"},{"first_name":"Nafisa M.","last_name":"Jadavji","full_name":"Jadavji, Nafisa M."},{"full_name":"Shah, Aparna P.","last_name":"Shah","first_name":"Aparna P."},{"full_name":"Davla, Sejal","first_name":"Sejal","last_name":"Davla"}],"month":"04","article_processing_charge":"No","language":[{"iso":"eng"}]},{"article_processing_charge":"No","volume":189,"language":[{"iso":"eng"}],"file":[{"file_size":3117435,"access_level":"open_access","creator":"mwintrae","checksum":"1787baef1523d6d93753b90d0c109a6d","file_id":"9346","relation":"main_file","success":1,"file_name":"df_socg_final_version.pdf","date_updated":"2021-04-22T08:08:14Z","date_created":"2021-04-22T08:08:14Z","content_type":"application/pdf"}],"has_accepted_license":"1","month":"06","author":[{"last_name":"Edelsbrunner","first_name":"Herbert","orcid":"0000-0002-9823-6833","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","full_name":"Edelsbrunner, Herbert"},{"full_name":"Heiss, Teresa","id":"4879BB4E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-1780-2689","last_name":"Heiss","first_name":"Teresa"},{"full_name":" Kurlin , Vitaliy","first_name":"Vitaliy","last_name":" Kurlin "},{"last_name":"Smith","first_name":"Philip","full_name":"Smith, Philip"},{"id":"307CFBC8-F248-11E8-B48F-1D18A9856A87","full_name":"Wintraecken, Mathijs","first_name":"Mathijs","last_name":"Wintraecken","orcid":"0000-0002-7472-2220"}],"oa_version":"Published Version","project":[{"call_identifier":"H2020","name":"Alpha Shape Theory Extended","_id":"266A2E9E-B435-11E9-9278-68D0E5697425","grant_number":"788183"},{"name":"Discretization in Geometry and Dynamics","grant_number":"I4887","_id":"0aa4bc98-070f-11eb-9043-e6fff9c6a316"},{"_id":"25C5A090-B435-11E9-9278-68D0E5697425","grant_number":"Z00312","name":"The Wittgenstein Prize","call_identifier":"FWF"},{"_id":"260C2330-B435-11E9-9278-68D0E5697425","grant_number":"754411","name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020"}],"quality_controlled":"1","ec_funded":1,"conference":{"location":"Virtual","name":"SoCG: Symposium on Computational Geometry","start_date":"2021-06-07","end_date":"2021-06-11"},"status":"public","publication_identifier":{"issn":["1868-8969"]},"type":"conference","_id":"9345","date_created":"2021-04-22T08:09:58Z","title":"The density fingerprint of a periodic point set","publisher":"Schloss Dagstuhl - Leibniz-Zentrum für Informatik","file_date_updated":"2021-04-22T08:08:14Z","date_published":"2021-06-02T00:00:00Z","ddc":["004","516"],"abstract":[{"text":"Modeling a crystal as a periodic point set, we present a fingerprint consisting of density functionsthat facilitates the efficient search for new materials and material properties. We prove invarianceunder isometries, continuity, and completeness in the generic case, which are necessary featuresfor the reliable comparison of crystals. The proof of continuity integrates methods from discretegeometry and lattice theory, while the proof of generic completeness combines techniques fromgeometry with analysis. The fingerprint has a fast algorithm based on Brillouin zones and relatedinclusion-exclusion formulae. We have implemented the algorithm and describe its application tocrystal structure prediction.","lang":"eng"}],"publication_status":"published","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"user_id":"D865714E-FA4E-11E9-B85B-F5C5E5697425","alternative_title":["LIPIcs"],"citation":{"ieee":"H. Edelsbrunner, T. Heiss, V.  Kurlin , P. Smith, and M. Wintraecken, “The density fingerprint of a periodic point set,” in <i>37th International Symposium on Computational Geometry (SoCG 2021)</i>, Virtual, 2021, vol. 189, p. 32:1-32:16.","ista":"Edelsbrunner H, Heiss T,  Kurlin  V, Smith P, Wintraecken M. 2021. The density fingerprint of a periodic point set. 37th International Symposium on Computational Geometry (SoCG 2021). SoCG: Symposium on Computational Geometry, LIPIcs, vol. 189, 32:1-32:16.","ama":"Edelsbrunner H, Heiss T,  Kurlin  V, Smith P, Wintraecken M. The density fingerprint of a periodic point set. In: <i>37th International Symposium on Computational Geometry (SoCG 2021)</i>. Vol 189. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2021:32:1-32:16. doi:<a href=\"https://doi.org/10.4230/LIPIcs.SoCG.2021.32\">10.4230/LIPIcs.SoCG.2021.32</a>","chicago":"Edelsbrunner, Herbert, Teresa Heiss, Vitaliy  Kurlin , Philip Smith, and Mathijs Wintraecken. “The Density Fingerprint of a Periodic Point Set.” In <i>37th International Symposium on Computational Geometry (SoCG 2021)</i>, 189:32:1-32:16. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2021. <a href=\"https://doi.org/10.4230/LIPIcs.SoCG.2021.32\">https://doi.org/10.4230/LIPIcs.SoCG.2021.32</a>.","apa":"Edelsbrunner, H., Heiss, T.,  Kurlin , V., Smith, P., &#38; Wintraecken, M. (2021). The density fingerprint of a periodic point set. In <i>37th International Symposium on Computational Geometry (SoCG 2021)</i> (Vol. 189, p. 32:1-32:16). Virtual: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. <a href=\"https://doi.org/10.4230/LIPIcs.SoCG.2021.32\">https://doi.org/10.4230/LIPIcs.SoCG.2021.32</a>","short":"H. Edelsbrunner, T. Heiss, V.  Kurlin , P. Smith, M. Wintraecken, in:, 37th International Symposium on Computational Geometry (SoCG 2021), Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2021, p. 32:1-32:16.","mla":"Edelsbrunner, Herbert, et al. “The Density Fingerprint of a Periodic Point Set.” <i>37th International Symposium on Computational Geometry (SoCG 2021)</i>, vol. 189, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2021, p. 32:1-32:16, doi:<a href=\"https://doi.org/10.4230/LIPIcs.SoCG.2021.32\">10.4230/LIPIcs.SoCG.2021.32</a>."},"date_updated":"2023-02-23T13:55:40Z","department":[{"_id":"HeEd"}],"publication":"37th International Symposium on Computational Geometry (SoCG 2021)","intvolume":"       189","year":"2021","page":"32:1-32:16","day":"02","doi":"10.4230/LIPIcs.SoCG.2021.32","acknowledgement":"The authors thank Janos Pach for insightful discussions on the topic of thispaper, Morteza Saghafian for finding the one-dimensional counterexample mentioned in Section 5,and Larry Andrews for generously sharing his crystallographic perspective.","oa":1},{"publication":"Journal of Functional Analysis","arxiv":1,"intvolume":"       281","scopus_import":"1","year":"2021","day":"07","doi":"10.1016/j.jfa.2021.109029","acknowledgement":"GDG gratefully acknowledges the financial support of HIM Bonn in the framework of the 2019 Junior Trimester Programs “Kinetic Theory” and “Randomness, PDEs and Nonlinear Fluctuations” and the hospitality at the University of Rome La Sapienza during his frequent visits.","oa":1,"title":"Sharp tunneling estimates for a double-well model in infinite dimension","publisher":"Elsevier","date_published":"2021-04-07T00:00:00Z","isi":1,"publication_status":"published","abstract":[{"lang":"eng","text":"We consider the stochastic quantization of a quartic double-well energy functional in the semiclassical regime and derive optimal asymptotics for the exponentially small splitting of the ground state energy. Our result provides an infinite-dimensional version of some sharp tunneling estimates known in finite dimensions for semiclassical Witten Laplacians in degree zero. From a stochastic point of view it proves that the L2 spectral gap of the stochastic one-dimensional Allen-Cahn equation in finite volume satisfies a Kramers-type formula in the limit of vanishing noise. We work with finite-dimensional lattice approximations and establish semiclassical estimates which are uniform in the dimension. Our key estimate shows that the constant separating the two exponentially small eigenvalues from the rest of the spectrum can be taken independently of the dimension."}],"external_id":{"isi":["000644702800005"],"arxiv":["1911.03187"]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","citation":{"ieee":"M. Brooks and G. Di Gesù, “Sharp tunneling estimates for a double-well model in infinite dimension,” <i>Journal of Functional Analysis</i>, vol. 281, no. 3. Elsevier, 2021.","apa":"Brooks, M., &#38; Di Gesù, G. (2021). Sharp tunneling estimates for a double-well model in infinite dimension. <i>Journal of Functional Analysis</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.jfa.2021.109029\">https://doi.org/10.1016/j.jfa.2021.109029</a>","ama":"Brooks M, Di Gesù G. Sharp tunneling estimates for a double-well model in infinite dimension. <i>Journal of Functional Analysis</i>. 2021;281(3). doi:<a href=\"https://doi.org/10.1016/j.jfa.2021.109029\">10.1016/j.jfa.2021.109029</a>","chicago":"Brooks, Morris, and Giacomo Di Gesù. “Sharp Tunneling Estimates for a Double-Well Model in Infinite Dimension.” <i>Journal of Functional Analysis</i>. Elsevier, 2021. <a href=\"https://doi.org/10.1016/j.jfa.2021.109029\">https://doi.org/10.1016/j.jfa.2021.109029</a>.","ista":"Brooks M, Di Gesù G. 2021. Sharp tunneling estimates for a double-well model in infinite dimension. Journal of Functional Analysis. 281(3), 109029.","mla":"Brooks, Morris, and Giacomo Di Gesù. “Sharp Tunneling Estimates for a Double-Well Model in Infinite Dimension.” <i>Journal of Functional Analysis</i>, vol. 281, no. 3, 109029, Elsevier, 2021, doi:<a href=\"https://doi.org/10.1016/j.jfa.2021.109029\">10.1016/j.jfa.2021.109029</a>.","short":"M. Brooks, G. Di Gesù, Journal of Functional Analysis 281 (2021)."},"department":[{"_id":"RoSe"}],"date_updated":"2023-08-08T13:15:11Z","publication_identifier":{"eissn":["1096-0783"],"issn":["0022-1236"]},"status":"public","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1911.03187"}],"article_type":"original","type":"journal_article","_id":"9348","date_created":"2021-04-25T22:01:29Z","volume":281,"article_processing_charge":"No","language":[{"iso":"eng"}],"article_number":"109029","issue":"3","month":"04","author":[{"id":"B7ECF9FC-AA38-11E9-AC9A-0930E6697425","full_name":"Brooks, Morris","last_name":"Brooks","first_name":"Morris","orcid":"0000-0002-6249-0928"},{"full_name":"Di Gesù, Giacomo","first_name":"Giacomo","last_name":"Di Gesù"}],"oa_version":"Preprint","quality_controlled":"1"},{"year":"2021","day":"14","doi":"10.1088/1478-3975/abd0db","acknowledgement":"The AK group is supported by IST Austria and by the ERC under European Union Horizon 2020 research and innovation programme Grant 680037. Apologies to those whose work could not be mentioned due to limited space. We thank all my lab members, both past and present, for stimulating discussion. This work was funded by a Singapore Ministry of Education Tier 3 Grant, MOE2016-T3-1-005. We thank Francis Corson for continuous discussion and collaboration contributing to these views and for figure 4(A). PC is sponsored by the Institut Pasteur and the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie Grant Agreement No. 665807. Research in JG's laboratory is funded by the European Research Council under the European Union's Seventh Framework Programme (FP7/2007-2013)/ERC Grant Agreement No. 337635, Institut Pasteur, CNRS, Cercle FSER, Fondation pour la Recherche Medicale, the Vallee Foundation and the ANR-19-CE-13-0024 Grant. We thank Erez Braun and Alex Mogilner for comments on the manuscript and Niv Ierushalmi for help with figure 5. This project has received funding from the European Union's Horizon 2020 research and innovation programme under Grant Agreement No. ERC-2018-COG Grant 819174-HydraMechanics awarded to KK. EH thanks all lab members, as well as Pierre Recho, Tsuyoshi Hirashima, Diana Pinheiro and Carl-Philip Heisenberg, for fruitful discussions on these topics—and apologize for not being able to cite many very relevant publications due to the strict 10-reference limit. EH acknowledges the support of Austrian Science Fund (FWF) (P 31639) and the European Research Council under the European Union's Horizon 2020 Research and Innovation Programme Grant Agreements (851288). The authors acknowledge the inspiring scientists whose work could not be cited in this perspective due to space constraints; the members of the Gartner Lab for helpful discussions; the Barbara and Gerson Bakar Foundation, the Chan Zuckerberg Biohub Investigators Programme, the National Institute of Health, and the Centre for Cellular Construction, an NSF Science and Technology Centre. The Minc laboratory is currently funded by the CNRS and the European Research Council (CoG Forcaster No. 647073). Research in the lab of J-LM is supported by the Institut Curie, the Centre National de la Recherche Scientifique (CNRS), the Institut National de la Santé Et de la Recherche Médicale (INSERM), and is funded by grants from the ATIP-Avenir programme, the Fondation Schlumberger pour l'Éducation et la Recherche via the Fondation pour la Recherche Médicale, the European Research Council Starting Grant ERC-2017-StG 757557, the European Molecular Biology Organization Young Investigator programme (EMBO YIP), the INSERM transversal programme Human Development Cell Atlas (HuDeCA), Paris Sciences Lettres (PSL) 'nouvelle équipe' and QLife (17-CONV-0005) grants and Labex DEEP (ANR-11-LABX-0044) which are part of the IDEX PSL (ANR-10-IDEX-0001-02). We acknowledge useful discussions with Massimo Vergassola, Sebastian Streichan and my lab members. Work in my laboratory on Drosophila embryogenesis is partly supported by NIH-R01GM122936. The authors acknowledge the support by a grant from the European Research Council (Grant No. 682161). Lenne group is funded by a grant from the 'Investissements d'Avenir' French Government programme managed by the French National Research Agency (ANR-16-CONV-0001) and by the Excellence Initiative of Aix-Marseille University—A*MIDEX, and ANR projects MechaResp (ANR-17-CE13-0032) and AdGastrulo (ANR-19-CE13-0022).","oa":1,"publication":"Physical biology","intvolume":"        18","related_material":{"record":[{"status":"public","id":"13081","relation":"dissertation_contains"}]},"scopus_import":"1","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"external_id":{"pmid":["33276350"],"isi":["000640396400001"]},"citation":{"mla":"Lenne, Pierre François, et al. “Roadmap for the Multiscale Coupling of Biochemical and Mechanical Signals during Development.” <i>Physical Biology</i>, vol. 18, no. 4, 041501, IOP Publishing, 2021, doi:<a href=\"https://doi.org/10.1088/1478-3975/abd0db\">10.1088/1478-3975/abd0db</a>.","short":"P.F. Lenne, E. Munro, I. Heemskerk, A. Warmflash, L. Bocanegra, K. Kishi, A. Kicheva, Y. Long, A. Fruleux, A. Boudaoud, T.E. Saunders, P. Caldarelli, A. Michaut, J. Gros, Y. Maroudas-Sacks, K. Keren, E.B. Hannezo, Z.J. Gartner, B. Stormo, A. Gladfelter, A. Rodrigues, A. Shyer, N. Minc, J.L. Maître, S. Di Talia, B. Khamaisi, D. Sprinzak, S. Tlili, Physical Biology 18 (2021).","apa":"Lenne, P. F., Munro, E., Heemskerk, I., Warmflash, A., Bocanegra, L., Kishi, K., … Tlili, S. (2021). Roadmap for the multiscale coupling of biochemical and mechanical signals during development. <i>Physical Biology</i>. IOP Publishing. <a href=\"https://doi.org/10.1088/1478-3975/abd0db\">https://doi.org/10.1088/1478-3975/abd0db</a>","chicago":"Lenne, Pierre François, Edwin Munro, Idse Heemskerk, Aryeh Warmflash, Laura Bocanegra, Kasumi Kishi, Anna Kicheva, et al. “Roadmap for the Multiscale Coupling of Biochemical and Mechanical Signals during Development.” <i>Physical Biology</i>. IOP Publishing, 2021. <a href=\"https://doi.org/10.1088/1478-3975/abd0db\">https://doi.org/10.1088/1478-3975/abd0db</a>.","ama":"Lenne PF, Munro E, Heemskerk I, et al. Roadmap for the multiscale coupling of biochemical and mechanical signals during development. <i>Physical biology</i>. 2021;18(4). doi:<a href=\"https://doi.org/10.1088/1478-3975/abd0db\">10.1088/1478-3975/abd0db</a>","ista":"Lenne PF, Munro E, Heemskerk I, Warmflash A, Bocanegra L, Kishi K, Kicheva A, Long Y, Fruleux A, Boudaoud A, Saunders TE, Caldarelli P, Michaut A, Gros J, Maroudas-Sacks Y, Keren K, Hannezo EB, Gartner ZJ, Stormo B, Gladfelter A, Rodrigues A, Shyer A, Minc N, Maître JL, Di Talia S, Khamaisi B, Sprinzak D, Tlili S. 2021. Roadmap for the multiscale coupling of biochemical and mechanical signals during development. Physical biology. 18(4), 041501.","ieee":"P. F. Lenne <i>et al.</i>, “Roadmap for the multiscale coupling of biochemical and mechanical signals during development,” <i>Physical biology</i>, vol. 18, no. 4. IOP Publishing, 2021."},"date_updated":"2023-08-08T13:15:46Z","department":[{"_id":"AnKi"},{"_id":"EdHa"}],"title":"Roadmap for the multiscale coupling of biochemical and mechanical signals during development","publisher":"IOP Publishing","date_published":"2021-04-14T00:00:00Z","file_date_updated":"2021-04-27T08:38:35Z","pmid":1,"isi":1,"ddc":["570"],"abstract":[{"lang":"eng","text":"The way in which interactions between mechanics and biochemistry lead to the emergence of complex cell and tissue organization is an old question that has recently attracted renewed interest from biologists, physicists, mathematicians and computer scientists. Rapid advances in optical physics, microscopy and computational image analysis have greatly enhanced our ability to observe and quantify spatiotemporal patterns of signalling, force generation, deformation, and flow in living cells and tissues. Powerful new tools for genetic, biophysical and optogenetic manipulation are allowing us to perturb the underlying machinery that generates these patterns in increasingly sophisticated ways. Rapid advances in theory and computing have made it possible to construct predictive models that describe how cell and tissue organization and dynamics emerge from the local coupling of biochemistry and mechanics. Together, these advances have opened up a wealth of new opportunities to explore how mechanochemical patterning shapes organismal development. In this roadmap, we present a series of forward-looking case studies on mechanochemical patterning in development, written by scientists working at the interface between the physical and biological sciences, and covering a wide range of spatial and temporal scales, organisms, and modes of development. Together, these contributions highlight the many ways in which the dynamic coupling of mechanics and biochemistry shapes biological dynamics: from mechanoenzymes that sense force to tune their activity and motor output, to collectives of cells in tissues that flow and redistribute biochemical signals during development."}],"publication_status":"published","status":"public","publication_identifier":{"eissn":["1478-3975"]},"_id":"9349","type":"journal_article","article_type":"original","date_created":"2021-04-25T22:01:29Z","ec_funded":1,"author":[{"last_name":"Lenne","first_name":"Pierre François","full_name":"Lenne, Pierre François"},{"full_name":"Munro, Edwin","last_name":"Munro","first_name":"Edwin"},{"last_name":"Heemskerk","first_name":"Idse","full_name":"Heemskerk, Idse"},{"first_name":"Aryeh","last_name":"Warmflash","full_name":"Warmflash, Aryeh"},{"id":"4896F754-F248-11E8-B48F-1D18A9856A87","full_name":"Bocanegra, Laura","first_name":"Laura","last_name":"Bocanegra"},{"id":"3065DFC4-F248-11E8-B48F-1D18A9856A87","full_name":"Kishi, Kasumi","last_name":"Kishi","first_name":"Kasumi"},{"id":"3959A2A0-F248-11E8-B48F-1D18A9856A87","full_name":"Kicheva, Anna","last_name":"Kicheva","first_name":"Anna","orcid":"0000-0003-4509-4998"},{"first_name":"Yuchen","last_name":"Long","full_name":"Long, Yuchen"},{"last_name":"Fruleux","first_name":"Antoine","full_name":"Fruleux, Antoine"},{"full_name":"Boudaoud, Arezki","first_name":"Arezki","last_name":"Boudaoud"},{"full_name":"Saunders, Timothy E.","last_name":"Saunders","first_name":"Timothy E."},{"last_name":"Caldarelli","first_name":"Paolo","full_name":"Caldarelli, Paolo"},{"full_name":"Michaut, Arthur","last_name":"Michaut","first_name":"Arthur"},{"last_name":"Gros","first_name":"Jerome","full_name":"Gros, Jerome"},{"first_name":"Yonit","last_name":"Maroudas-Sacks","full_name":"Maroudas-Sacks, Yonit"},{"full_name":"Keren, Kinneret","first_name":"Kinneret","last_name":"Keren"},{"last_name":"Hannezo","first_name":"Edouard B","orcid":"0000-0001-6005-1561","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","full_name":"Hannezo, Edouard B"},{"last_name":"Gartner","first_name":"Zev J.","full_name":"Gartner, Zev J."},{"first_name":"Benjamin","last_name":"Stormo","full_name":"Stormo, Benjamin"},{"first_name":"Amy","last_name":"Gladfelter","full_name":"Gladfelter, Amy"},{"first_name":"Alan","last_name":"Rodrigues","full_name":"Rodrigues, Alan"},{"full_name":"Shyer, Amy","last_name":"Shyer","first_name":"Amy"},{"first_name":"Nicolas","last_name":"Minc","full_name":"Minc, Nicolas"},{"last_name":"Maître","first_name":"Jean Léon","full_name":"Maître, Jean Léon"},{"first_name":"Stefano","last_name":"Di Talia","full_name":"Di Talia, Stefano"},{"first_name":"Bassma","last_name":"Khamaisi","full_name":"Khamaisi, Bassma"},{"full_name":"Sprinzak, David","last_name":"Sprinzak","first_name":"David"},{"last_name":"Tlili","first_name":"Sham","full_name":"Tlili, Sham"}],"oa_version":"Published Version","project":[{"call_identifier":"H2020","name":"Coordination of Patterning And Growth In the Spinal Cord","grant_number":"680037","_id":"B6FC0238-B512-11E9-945C-1524E6697425"},{"name":"Active mechano-chemical description of the cell cytoskeleton","_id":"268294B6-B435-11E9-9278-68D0E5697425","grant_number":"P31639","call_identifier":"FWF"},{"name":"Design Principles of Branching Morphogenesis","grant_number":"851288","_id":"05943252-7A3F-11EA-A408-12923DDC885E","call_identifier":"H2020"}],"quality_controlled":"1","article_processing_charge":"No","volume":18,"language":[{"iso":"eng"}],"issue":"4","file":[{"file_size":6296324,"access_level":"open_access","creator":"cziletti","file_id":"9355","checksum":"4f52082549d3561c4c15d4d8d84ca5d8","success":1,"relation":"main_file","file_name":"2021_PhysBio_Lenne.pdf","date_updated":"2021-04-27T08:38:35Z","date_created":"2021-04-27T08:38:35Z","content_type":"application/pdf"}],"article_number":"041501","has_accepted_license":"1","month":"04"},{"acknowledgement":"T.S. acknowledges funding by the research program “The Active Matter Physics of Collective Metastasis,” which is financed by the Dutch Research Council (NWO).","day":"05","page":"4182-4192","year":"2021","doi":"10.1016/j.bpj.2021.03.025","oa":1,"intvolume":"       120","publication":"Biophysical Journal","scopus_import":"1","related_material":{"record":[{"id":"12368","relation":"dissertation_contains","status":"public"}]},"external_id":{"isi":["000704646900006"],"pmid":["33794149"]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","department":[{"_id":"CaHe"}],"date_updated":"2023-08-08T13:14:10Z","citation":{"short":"F.N. Arslan, J. Eckert, T. Schmidt, C.-P.J. Heisenberg, Biophysical Journal 120 (2021) 4182–4192.","mla":"Arslan, Feyza N., et al. “Holding It Together: When Cadherin Meets Cadherin.” <i>Biophysical Journal</i>, vol. 120, Biophysical Society, 2021, pp. 4182–92, doi:<a href=\"https://doi.org/10.1016/j.bpj.2021.03.025\">10.1016/j.bpj.2021.03.025</a>.","apa":"Arslan, F. N., Eckert, J., Schmidt, T., &#38; Heisenberg, C.-P. J. (2021). Holding it together: when cadherin meets cadherin. <i>Biophysical Journal</i>. Biophysical Society. <a href=\"https://doi.org/10.1016/j.bpj.2021.03.025\">https://doi.org/10.1016/j.bpj.2021.03.025</a>","chicago":"Arslan, Feyza N, Julia Eckert, Thomas Schmidt, and Carl-Philipp J Heisenberg. “Holding It Together: When Cadherin Meets Cadherin.” <i>Biophysical Journal</i>. Biophysical Society, 2021. <a href=\"https://doi.org/10.1016/j.bpj.2021.03.025\">https://doi.org/10.1016/j.bpj.2021.03.025</a>.","ista":"Arslan FN, Eckert J, Schmidt T, Heisenberg C-PJ. 2021. Holding it together: when cadherin meets cadherin. Biophysical Journal. 120, 4182–4192.","ama":"Arslan FN, Eckert J, Schmidt T, Heisenberg C-PJ. Holding it together: when cadherin meets cadherin. <i>Biophysical Journal</i>. 2021;120:4182-4192. doi:<a href=\"https://doi.org/10.1016/j.bpj.2021.03.025\">10.1016/j.bpj.2021.03.025</a>","ieee":"F. N. Arslan, J. Eckert, T. Schmidt, and C.-P. J. Heisenberg, “Holding it together: when cadherin meets cadherin,” <i>Biophysical Journal</i>, vol. 120. Biophysical Society, pp. 4182–4192, 2021."},"pmid":1,"publisher":"Biophysical Society","date_published":"2021-10-05T00:00:00Z","title":"Holding it together: when cadherin meets cadherin","publication_status":"published","abstract":[{"text":"Intercellular adhesion is the key to multicellularity, and its malfunction plays an important role in various developmental and disease-related processes. Although it has been intensively studied by both biologists and physicists, a commonly accepted definition of cell-cell adhesion is still being debated. Cell-cell adhesion has been described at the molecular scale as a function of adhesion receptors controlling binding affinity, at the cellular scale as resistance to detachment forces or modulation of surface tension, and at the tissue scale as a regulator of cellular rearrangements and morphogenesis. In this review, we aim to summarize and discuss recent advances in the molecular, cellular, and theoretical description of cell-cell adhesion, ranging from biomimetic models to the complexity of cells and tissues in an organismal context. In particular, we will focus on cadherin-mediated cell-cell adhesion and the role of adhesion signaling and mechanosensation therein, two processes central for understanding the biological and physical basis of cell-cell adhesion.","lang":"eng"}],"isi":1,"status":"public","publication_identifier":{"issn":["0006-3495"],"eissn":["1542-0086"]},"main_file_link":[{"url":"https://scholarlypublications.universiteitleiden.nl/access/item%3A3251048/view","open_access":"1"}],"date_created":"2021-04-25T22:01:30Z","article_type":"original","_id":"9350","type":"journal_article","author":[{"orcid":"0000-0001-5809-9566","last_name":"Arslan","first_name":"Feyza N","full_name":"Arslan, Feyza N","id":"49DA7910-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Eckert, Julia","last_name":"Eckert","first_name":"Julia"},{"first_name":"Thomas","last_name":"Schmidt","full_name":"Schmidt, Thomas"},{"full_name":"Heisenberg, Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0912-4566","last_name":"Heisenberg","first_name":"Carl-Philipp J"}],"quality_controlled":"1","oa_version":"Published Version","language":[{"iso":"eng"}],"volume":120,"article_processing_charge":"No","month":"10"}]