@inproceedings{12979,
  abstract     = {Color and gloss are fundamental aspects of surface appearance. State-of-the-art fabrication techniques can manipulate both properties of the printed 3D objects. However, in the context of appearance reproduction, perceptual aspects of color and gloss are usually handled separately, even though previous perceptual studies suggest their interaction. Our work is motivated by previous studies demonstrating a perceived color shift due to a change in the object's gloss, i.e., two samples with the same color but different surface gloss appear as they have different colors. In this paper, we conduct new experiments which support this observation and provide insights into the magnitude and direction of the perceived color change. We use the observations as guidance to design a new method that estimates and corrects the color shift enabling the fabrication of objects with the same perceived color but different surface gloss. We formulate the problem as an optimization procedure solved using differentiable rendering. We evaluate the effectiveness of our method in perceptual experiments with 3D objects fabricated using a multi-material 3D printer and demonstrate potential applications. },
  author       = {Condor, Jorge and Piovarci, Michael and Bickel, Bernd and Didyk, Piotr},
  booktitle    = {SIGGRAPH ’23 Conference Proceedings},
  isbn         = {9798400701597},
  keywords     = {color, gloss, perception, color compensation, color management},
  location     = {Los Angeles, CA, United States},
  publisher    = {Association for Computing Machinery},
  title        = {{Gloss-aware color correction for 3D printing}},
  doi          = {10.1145/3588432.3591546},
  year         = {2023},
}

@article{12984,
  abstract     = {Tattoos are a highly popular medium, with both artistic and medical applications. Although the mechanical process of tattoo application has evolved historically, the results are reliant on the artisanal skill of the artist. This can be especially challenging for some skin tones, or in cases where artists lack experience. We provide the first systematic overview of tattooing as a computational fabrication technique. We built an automated tattooing rig and a recipe for the creation of silicone sheets mimicking realistic skin tones, which allowed us to create an accurate model predicting tattoo appearance. This enables several exciting applications including tattoo previewing, color retargeting, novel ink spectra optimization, color-accurate prosthetics, and more.},
  author       = {Piovarci, Michael and Chapiro, Alexandre and Bickel, Bernd},
  issn         = {1557-7368},
  journal      = {Transactions on Graphics},
  keywords     = {appearance, modeling, reproduction, tattoo, skin color, gamut mapping, ink-optimization, prosthetic},
  location     = {Los Angeles, CA, United States},
  number       = {4},
  publisher    = {Association for Computing Machinery},
  title        = {{Skin-Screen: A computational fabrication framework for color tattoos}},
  doi          = {10.1145/3592432},
  volume       = {42},
  year         = {2023},
}

@article{13033,
  abstract     = {Current methods for assessing cell proliferation in 3D scaffolds rely on changes in metabolic activity or total DNA, however, direct quantification of cell number in 3D scaffolds remains a challenge. To address this issue, we developed an unbiased stereology approach that uses systematic-random sampling and thin focal-plane optical sectioning of the scaffolds followed by estimation of total cell number (StereoCount). This approach was validated against an indirect method for measuring the total DNA (DNA content); and the Bürker counting chamber, the current reference method for quantifying cell number. We assessed the total cell number for cell seeding density (cells per unit volume) across four values and compared the methods in terms of accuracy, ease-of-use and time demands. The accuracy of StereoCount markedly outperformed the DNA content for cases with ~ 10,000 and ~ 125,000 cells/scaffold. For cases with ~ 250,000 and ~ 375,000 cells/scaffold both StereoCount and DNA content showed lower accuracy than the Bürker but did not differ from each other. In terms of ease-of-use, there was a strong advantage for the StereoCount due to output in terms of absolute cell numbers along with the possibility for an overview of cell distribution and future use of automation for high throughput analysis. Taking together, the StereoCount method is an efficient approach for direct cell quantification in 3D collagen scaffolds. Its major benefit is that automated StereoCount could accelerate research using 3D scaffolds focused on drug discovery for a wide variety of human diseases.},
  author       = {Zavadakova, Anna and Vistejnova, Lucie and Belinova, Tereza and Tichanek, Filip and Bilikova, Dagmar and Mouton, Peter R.},
  issn         = {2045-2322},
  journal      = {Scientific Reports},
  keywords     = {Multidisciplinary},
  number       = {1},
  publisher    = {Springer Nature},
  title        = {{Novel stereological method for estimation of cell counts in 3D collagen scaffolds}},
  doi          = {10.1038/s41598-023-35162-z},
  volume       = {13},
  year         = {2023},
}

@article{13039,
  abstract     = {We calculate reflectivities of dynamically compressed water, water-ethanol mixtures, and ammonia at infrared and optical wavelengths with density functional theory and molecular dynamics simulations. The influence of the exchange-correlation functional on the results is examined in detail. Our findings indicate that the consistent use of the HSE hybrid functional reproduces experimental results much better than the commonly used PBE functional. The HSE functional offers not only a more accurate description of the electronic band gap but also shifts the onset of molecular dissociation in the molecular dynamics simulations to significantly higher pressures. We also highlight the importance of using accurate reference standards in reflectivity experiments and reanalyze infrared and optical reflectivity data from recent experiments. Thus, our combined theoretical and experimental work explains and resolves lingering discrepancies between calculations and measurements for the investigated molecular substances under shock compression.},
  author       = {French, Martin and Bethkenhagen, Mandy and Ravasio, Alessandra and Hernandez, Jean Alexis},
  issn         = {2469-9969},
  journal      = {Physical Review B},
  number       = {13},
  publisher    = {American Physical Society},
  title        = {{Ab initio calculation of the reflectivity of molecular fluids under shock compression}},
  doi          = {10.1103/PhysRevB.107.134109},
  volume       = {107},
  year         = {2023},
}

@article{13041,
  abstract     = {A series of triarylamines was synthesised and screened for their suitability as catholytes in redox flow batteries using cyclic voltammetry (CV). Tris(4-aminophenyl)amine was found to be the strongest candidate. Solubility and initial electrochemical performance were promising; however, polymerisation was observed during electrochemical cycling leading to rapid capacity fade prescribed to a loss of accessible active material and the limitation of ion transport processes within the cell. A mixed electrolyte system of H3PO4 and HCl was found to inhibit polymerisation producing oligomers that consumed less active material reducing rates of degradation in the redox flow battery. Under these conditions Coulombic efficiency improved by over 4 %, the maximum number of cycles more than quadrupled and an additional theoretical capacity of 20 % was accessed. This paper is, to our knowledge, the first example of triarylamines as catholytes in all-aqueous redox flow batteries and emphasises the impact supporting electrolytes can have on electrochemical performance.},
  author       = {Farag, Nadia L. and Jethwa, Rajesh B and Beardmore, Alice E. and Insinna, Teresa and O'Keefe, Christopher A. and Klusener, Peter A.A. and Grey, Clare P. and Wright, Dominic S.},
  issn         = {1864-564X},
  journal      = {ChemSusChem},
  number       = {13},
  publisher    = {Wiley},
  title        = {{Triarylamines as catholytes in aqueous organic redox flow batteries}},
  doi          = {10.1002/cssc.202300128},
  volume       = {16},
  year         = {2023},
}

@article{13042,
  abstract     = {Let Lc,n denote the size of the longest cycle in G(n, c/n),c >1 constant.  We show that there exists a continuous function f(c) such that Lc,n/n→f(c) a.s.  for c>20,  thus  extending  a  result  of  Frieze  and  the  author  to  smaller  values  of c. Thereafter,  for c>20,  we  determine  the  limit  of  the  probability  that G(n, c/n)contains  cycles  of  every  length  between  the  length  of  its  shortest  and  its  longest cycles as n→∞.},
  author       = {Anastos, Michael},
  issn         = {1077-8926},
  journal      = {Electronic Journal of Combinatorics},
  number       = {2},
  publisher    = {Electronic Journal of Combinatorics},
  title        = {{A note on long cycles in sparse random graphs}},
  doi          = {10.37236/11471},
  volume       = {30},
  year         = {2023},
}

@article{13043,
  abstract     = {We derive a weak-strong uniqueness principle for BV solutions to multiphase mean curvature flow of triple line clusters in three dimensions. Our proof is based on the explicit construction
of a gradient flow calibration in the sense of the recent work of Fischer et al. (2020) for any such
cluster. This extends the two-dimensional construction to the three-dimensional case of surfaces
meeting along triple junctions.},
  author       = {Hensel, Sebastian and Laux, Tim},
  issn         = {1463-9971},
  journal      = {Interfaces and Free Boundaries},
  number       = {1},
  pages        = {37--107},
  publisher    = {EMS Press},
  title        = {{Weak-strong uniqueness for the mean curvature flow of double bubbles}},
  doi          = {10.4171/IFB/484},
  volume       = {25},
  year         = {2023},
}

@article{13044,
  abstract     = {Singlet oxygen (1O2) formation is now recognised as a key aspect of non-aqueous oxygen redox chemistry. For identifying 1O2, chemical trapping via 9,10-dimethylanthracene (DMA) to form the endoperoxide (DMA-O2) has become the mainstay method due to its sensitivity, selectivity, and ease of use. While DMA has been shown to be selective for 1O2, rather than forming DMA-O2 with a wide variety of potentially reactive O-containing species, false positives might hypothetically be obtained in the presence of previously overlooked species. Here, we first give unequivocal direct spectroscopic proof by the 1O2-specific near infrared (NIR) emission at 1270 nm for the previously proposed 1O2 formation pathways, which centre around superoxide disproportionation. We then show that peroxocarbonates, common intermediates in metal-O2 and metal carbonate electrochemistry, do not produce false-positive DMA-O2. Moreover, we identify a previously unreported 1O2-forming pathway through the reaction of CO2 with superoxide. Overall, we give unequivocal proof for 1O2 formation in non-aqueous oxygen redox and show that chemical trapping with DMA is a reliable method to assess 1O2 formation.},
  author       = {Mondal, Soumyadip and Jethwa, Rajesh B and Pant, Bhargavi and Hauschild, Robert and Freunberger, Stefan Alexander},
  issn         = {1364-5498},
  journal      = {Faraday Discussions},
  keywords     = {Physical and Theoretical Chemistry},
  publisher    = {Royal Society of Chemistry},
  title        = {{Singlet oxygen in non-aqueous oxygen redox: Direct spectroscopic evidence for formation pathways and reliability of chemical probes}},
  doi          = {10.1039/d3fd00088e},
  year         = {2023},
}

@inproceedings{13048,
  abstract     = {In this paper we introduce a pruning of the medial axis called the (λ,α)-medial axis (axλα). We prove that the (λ,α)-medial axis of a set K is stable in a Gromov-Hausdorff sense under weak assumptions. More formally we prove that if K and K′ are close in the Hausdorff (dH) sense then the (λ,α)-medial axes of K and K′ are close as metric spaces, that is the Gromov-Hausdorff distance (dGH) between the two is 1/4-Hölder in the sense that dGH (axλα(K),axλα(K′)) ≲ dH(K,K′)1/4. The Hausdorff distance between the two medial axes is also bounded, by dH (axλα(K),λα(K′)) ≲ dH(K,K′)1/2. These quantified stability results provide guarantees for practical computations of medial axes from approximations. Moreover, they provide key ingredients for studying the computability of the medial axis in the context of computable analysis.},
  author       = {Lieutier, André and Wintraecken, Mathijs},
  booktitle    = {Proceedings of the 55th Annual ACM Symposium on Theory of Computing},
  isbn         = {9781450399135},
  location     = {Orlando, FL, United States},
  pages        = {1768--1776},
  publisher    = {Association for Computing Machinery},
  title        = {{Hausdorff and Gromov-Hausdorff stable subsets of the medial axis}},
  doi          = {10.1145/3564246.3585113},
  year         = {2023},
}

@article{13049,
  abstract     = {We propose a computational design approach for covering a surface with individually addressable RGB LEDs, effectively forming a low-resolution surface screen. To achieve a low-cost and scalable approach, we propose creating designs from flat PCB panels bent in-place along the surface of a 3D printed core. Working with standard rigid PCBs enables the use of
established PCB manufacturing services, allowing the fabrication of designs with several hundred LEDs. 
Our approach optimizes the PCB geometry for folding, and then jointly optimizes the LED packing, circuit and routing, solving a challenging layout problem under strict manufacturing requirements. Unlike paper, PCBs cannot bend beyond a certain point without breaking. Therefore, we introduce parametric cut patterns acting as hinges, designed to allow bending while remaining compact. To tackle the joint optimization of placement, circuit and routing, we propose a specialized algorithm that splits the global problem into one sub-problem per triangle, which is then individually solved.
Our technique generates PCB blueprints in a completely automated way. After being fabricated by a PCB manufacturing service, the boards are bent and glued by the user onto the 3D printed support. We demonstrate our technique on a range of physical models and virtual examples, creating intricate surface light patterns from hundreds of LEDs.},
  author       = {Freire, Marco and Bhargava, Manas and Schreck, Camille and Hugron, Pierre-Alexandre and Bickel, Bernd and Lefebvre, Sylvain},
  issn         = {1557-7368},
  journal      = {Transactions on Graphics},
  keywords     = {PCB design and layout, Mesh geometry models},
  location     = {Los Angeles, CA, United States},
  number       = {4},
  publisher    = {Association for Computing Machinery},
  title        = {{PCBend: Light up your 3D shapes with foldable circuit boards}},
  doi          = {10.1145/3592411},
  volume       = {42},
  year         = {2023},
}

@inbook{13052,
  abstract     = {Imaging of the immunological synapse (IS) between dendritic cells (DCs) and T cells in suspension is hampered by suboptimal alignment of cell-cell contacts along the vertical imaging plane. This requires optical sectioning that often results in unsatisfactory resolution in time and space. Here, we present a workflow where DCs and T cells are confined between a layer of glass and polydimethylsiloxane (PDMS) that orients the cells along one, horizontal imaging plane, allowing for fast en-face-imaging of the DC-T cell IS.},
  author       = {Leithner, Alexander F and Merrin, Jack and Sixt, Michael K},
  booktitle    = {The Immune Synapse},
  editor       = {Baldari, Cosima and Dustin, Michael},
  isbn         = {9781071631348},
  issn         = {1940-6029},
  pages        = {137--147},
  publisher    = {Springer Nature},
  title        = {{En-Face Imaging of T Cell-Dendritic Cell Immunological Synapses}},
  doi          = {10.1007/978-1-0716-3135-5_9},
  volume       = {2654},
  year         = {2023},
}

@article{14653,
  abstract     = {Mass spectrometry imaging (MSI) is a powerful analytical technique for the two-dimensional (2D) localization of chemicals on surfaces. Conventional MSI experiments require to predefine the surface of interest based on photographic or microscopic images. Typically, these boundaries can no longer be changed or adjusted once the experiment has been started. In terms of a more interactive approach we recently developed a pen-like ionization interface which is directly connected to the mass spectrometer. The device allows the user to ionize chemicals by desorption electrospray ionization (DESI) and to freely move the interface over a surface of interest. A mini camera, which is mounted on the tip of the pen, magnifies the desorption area and enables a simple positioning of the pen. The combination of optical data from the camera module and chemical data obtained by mass analysis facilitates a novel type of imaging experiment: interactive mass spectrometry imaging (IMSI). For this application, we present a novel approach for a robust, optical flow-based motion detection. While the live video stream from the camera is used to track the pen's motion across the surface a post-acquisition algorithm correlates the coordinates of the pen trajectory with respective mass spectra obtained from a simultaneous mass spectrometric data acquisition. This algorithm is no longer dependent on a single, manually applied optical marker on the sample surface, which has to be visible on all video frames throughout the analysis. The advanced DESI-IMSI method was successfully tested on inkjet-printed letters as well as mouse brain tissue samples. Validation of the results was done by comparing DESI-IMSI with standard DESI-MSI data.},
  author       = {Kluibenschedl, Florian and Ploner, Anna and Meisenbichler, Christina and Konrat, Robert and Müller, Thomas},
  issn         = {1387-3806},
  journal      = {International Journal of Mass Spectrometry},
  publisher    = {Elsevier},
  title        = {{Advanced motion tracking for interactive mass spectrometry imaging (IMSI)}},
  doi          = {10.1016/j.ijms.2023.117168},
  volume       = {495},
  year         = {2023},
}

@article{10656,
  abstract     = {Idealized simulations of the tropical atmosphere have predicted that clouds can spontaneously clump together in space, despite perfectly homogeneous settings. This phenomenon has been called self-aggregation, and it results in a state where a moist cloudy region with intense deep convective storms is surrounded by extremely dry subsiding air devoid of deep clouds. We review here the main findings from theoretical work and idealized models of this phenomenon, highlighting the physical processes believed to play a key role in convective self-aggregation. We also review the growing literature on the importance and implications of this phenomenon for the tropical atmosphere, notably, for the hydrological cycle and for precipitation extremes, in our current and in a warming climate.},
  author       = {Muller, Caroline J and Yang, Da and Craig, George and Cronin, Timothy and Fildier, Benjamin and Haerter, Jan O. and Hohenegger, Cathy and Mapes, Brian and Randall, David and Shamekh, Sara and Sherwood, Steven C.},
  issn         = {1545-4479},
  journal      = {Annual Review of Fluid Mechanics},
  pages        = {133--157},
  publisher    = {Annual Reviews},
  title        = {{Spontaneous aggregation of convective storms}},
  doi          = {10.1146/annurev-fluid-022421-011319},
  volume       = {54},
  year         = {2022},
}

@article{10658,
  abstract     = {We analyse how migration from a large mainland influences genetic load and population numbers on an island, in a scenario where fitness-affecting variants are unconditionally deleterious, and where numbers decline with increasing load. Our analysis shows that migration can have qualitatively different effects, depending on the total mutation target and fitness effects of deleterious variants. In particular, we find that populations exhibit a genetic Allee effect across a wide range of parameter combinations, when variants are partially recessive, cycling between low-load (large-population) and high-load (sink) states. Increased migration reduces load in the sink state (by increasing heterozygosity) but further inflates load in the large-population state (by hindering purging). We identify various critical parameter thresholds at which one or other stable state collapses, and discuss how these thresholds are influenced by the genetic versus demographic effects of migration. Our analysis is based on a ‘semi-deterministic’ analysis, which accounts for genetic drift but neglects demographic stochasticity. We also compare against simulations which account for both demographic stochasticity and drift. Our results clarify the importance of gene flow as a key determinant of extinction risk in peripheral populations, even in the absence of ecological gradients. This article is part of the theme issue ‘Species’ ranges in the face of changing environments (part I)’.},
  author       = {Sachdeva, Himani and Olusanya, Oluwafunmilola O and Barton, Nicholas H},
  issn         = {1471-2970},
  journal      = {Philosophical Transactions of the Royal Society B},
  number       = {1846},
  publisher    = {The Royal Society},
  title        = {{Genetic load and extinction in peripheral populations: The roles of migration, drift and demographic stochasticity}},
  doi          = {10.1098/rstb.2021.0010},
  volume       = {377},
  year         = {2022},
}

@article{10702,
  abstract     = {Background: Blood-based markers of cognitive functioning might provide an accessible way to track neurodegeneration years prior to clinical manifestation of cognitive impairment and dementia. Results: Using blood-based epigenome-wide analyses of general cognitive function, we show that individual differences in DNA methylation (DNAm) explain 35.0% of the variance in general cognitive function (g). A DNAm predictor explains ~4% of the variance, independently of a polygenic score, in two external cohorts. It also associates with circulating levels of neurology- and inflammation-related proteins, global brain imaging metrics, and regional cortical volumes. Conclusions: As sample sizes increase, the ability to assess cognitive function from DNAm data may be informative in settings where cognitive testing is unreliable or unavailable.},
  author       = {McCartney, Daniel L. and Hillary, Robert F. and Conole, Eleanor L.S. and Banos, Daniel Trejo and Gadd, Danni A. and Walker, Rosie M. and Nangle, Cliff and Flaig, Robin and Campbell, Archie and Murray, Alison D. and Maniega, Susana Muñoz and Valdés-Hernández, María Del C. and Harris, Mathew A. and Bastin, Mark E. and Wardlaw, Joanna M. and Harris, Sarah E. and Porteous, David J. and Tucker-Drob, Elliot M. and McIntosh, Andrew M. and Evans, Kathryn L. and Deary, Ian J. and Cox, Simon R. and Robinson, Matthew Richard and Marioni, Riccardo E.},
  issn         = {1474-760X},
  journal      = {Genome Biology},
  number       = {1},
  publisher    = {Springer Nature},
  title        = {{Blood-based epigenome-wide analyses of cognitive abilities}},
  doi          = {10.1186/s13059-021-02596-5},
  volume       = {23},
  year         = {2022},
}

@article{10703,
  abstract     = {When crawling through the body, leukocytes often traverse tissues that are densely packed with extracellular matrix and other cells, and this raises the question: How do leukocytes overcome compressive mechanical loads? Here, we show that the actin cortex of leukocytes is mechanoresponsive and that this responsiveness requires neither force sensing via the nucleus nor adhesive interactions with a substrate. Upon global compression of the cell body as well as local indentation of the plasma membrane, Wiskott-Aldrich syndrome protein (WASp) assembles into dot-like structures, providing activation platforms for Arp2/3 nucleated actin patches. These patches locally push against the external load, which can be obstructing collagen fibers or other cells, and thereby create space to facilitate forward locomotion. We show in vitro and in vivo that this WASp function is rate limiting for ameboid leukocyte migration in dense but not in loose environments and is required for trafficking through diverse tissues such as skin and lymph nodes.},
  author       = {Gaertner, Florian and Reis-Rodrigues, Patricia and De Vries, Ingrid and Hons, Miroslav and Aguilera, Juan and Riedl, Michael and Leithner, Alexander F and Tasciyan, Saren and Kopf, Aglaja and Merrin, Jack and Zheden, Vanessa and Kaufmann, Walter and Hauschild, Robert and Sixt, Michael K},
  issn         = {1878-1551},
  journal      = {Developmental Cell},
  number       = {1},
  pages        = {47--62.e9},
  publisher    = {Cell Press ; Elsevier},
  title        = {{WASp triggers mechanosensitive actin patches to facilitate immune cell migration in dense tissues}},
  doi          = {10.1016/j.devcel.2021.11.024},
  volume       = {57},
  year         = {2022},
}

@article{10704,
  abstract     = {We define and study the existence of very stable Higgs bundles on Riemann surfaces, how it implies a precise formula for the multiplicity of the very stable components of the global nilpotent cone and its relationship to mirror symmetry. The main ingredients are the Bialynicki-Birula theory of C∗-actions on semiprojective varieties, C∗ characters of indices of C∗-equivariant coherent sheaves, Hecke transformation for Higgs bundles, relative Fourier–Mukai transform along the Hitchin fibration, hyperholomorphic structures on universal bundles and cominuscule Higgs bundles.},
  author       = {Hausel, Tamás and Hitchin, Nigel},
  issn         = {1432-1297},
  journal      = {Inventiones Mathematicae},
  pages        = {893--989},
  publisher    = {Springer Nature},
  title        = {{Very stable Higgs bundles, equivariant multiplicity and mirror symmetry}},
  doi          = {10.1007/s00222-021-01093-7},
  volume       = {228},
  year         = {2022},
}

@article{10705,
  abstract     = {Although rigidity and jamming transitions have been widely studied in physics and material science, their importance in a number of biological processes, including embryo development, tissue homeostasis, wound healing, and disease progression, has only begun to be recognized in the past few years. The hypothesis that biological systems can undergo rigidity/jamming transitions is attractive, as it would allow these systems to change their material properties rapidly and strongly. However, whether such transitions indeed occur in biological systems, how they are being regulated, and what their physiological relevance might be, is still being debated. Here, we review theoretical and experimental advances from the past few years, focusing on the regulation and role of potential tissue rigidity transitions in different biological processes.},
  author       = {Hannezo, Edouard B and Heisenberg, Carl-Philipp J},
  issn         = {1879-3088},
  journal      = {Trends in Cell Biology},
  number       = {5},
  pages        = {P433--444},
  publisher    = {Cell Press},
  title        = {{Rigidity transitions in development and disease}},
  doi          = {10.1016/j.tcb.2021.12.006},
  volume       = {32},
  year         = {2022},
}

@article{10706,
  abstract     = {This is a collection of problems composed by some participants of the workshop “Differential Geometry, Billiards, and Geometric Optics” that took place at CIRM on October 4–8, 2021.},
  author       = {Bialy, Misha and Fiorebe, Corentin and Glutsyuk, Alexey and Levi, Mark and Plakhov, Alexander and Tabachnikov, Serge},
  issn         = {2199-6806},
  journal      = {Arnold Mathematical Journal},
  location     = {Hybrid},
  pages        = {411--422},
  publisher    = {Springer Nature},
  title        = {{Open problems on billiards and geometric optics}},
  doi          = {10.1007/s40598-022-00198-y},
  volume       = {8},
  year         = {2022},
}

@article{10712,
  abstract     = {Solute carriers are increasingly recognized as participating in a plethora of pathologies, including cancer. We describe here the involvement of the orphan solute carrier MFSD1 in the regulation of tumor cell migration. Loss of MFSD1 enabled higher levels of metastasis in a mouse model. We identified an increased migratory potential in MFSD1-/- tumor cells which was mediated by increased focal adhesion turn-over, reduced stability of mature inactive β1 integrin, and the resulting increased integrin activation index. We show that MFSD1 promoted recycling to the cell surface of endocytosed inactive β1 integrin and thereby protected β1 integrin from proteolytic degradation; this led to dampening of the integrin activation index. Furthermore, down-regulation of MFSD1 expression was observed during early steps of tumorigenesis and higher MFSD1 expression levels correlate with a better cancer patient prognosis. In sum, we describe a requirement for endolysosomal MFSD1 in efficient β1 integrin recycling to suppress tumor spread.},
  author       = {Roblek, Marko and Bicher, Julia and van Gogh, Merel and György, Attila and Seeböck, Rita and Szulc, Bozena and Damme, Markus and Olczak, Mariusz and Borsig, Lubor and Siekhaus, Daria E},
  issn         = {2234-943X},
  journal      = {Frontiers in Oncology},
  publisher    = {Frontiers},
  title        = {{The solute carrier MFSD1 decreases β1 integrin’s activation status and thus tumor metastasis}},
  doi          = {10.3389/fonc.2022.777634},
  volume       = {12},
  year         = {2022},
}

