---
_id: '10792'
abstract:
- lang: eng
  text: "Background\r\nProper cerebral cortical development depends on the tightly
    orchestrated migration of newly born neurons from the inner ventricular and subventricular
    zones to the outer cortical plate. Any disturbance in this process during prenatal
    stages may lead to neuronal migration disorders (NMDs), which can vary in extent
    from focal to global. Furthermore, NMDs show a substantial comorbidity with other
    neurodevelopmental disorders, notably autism spectrum disorders (ASDs). Our previous
    work demonstrated focal neuronal migration defects in mice carrying loss-of-function
    alleles of the recognized autism risk gene WDFY3. However, the cellular origins
    of these defects in Wdfy3 mutant mice remain elusive and uncovering it will provide
    critical insight into WDFY3-dependent disease pathology .\r\nMethods\r\nHere,
    in an effort to untangle the origins of NMDs in Wdfy3lacZ mice, we employed mosaic
    analysis with double markers (MADM). MADM technology enabled us to genetically
    distinctly track and phenotypically analyze mutant and wild type cells concomitantly
    in vivo using immunofluorescent techniques.\r\nResults\r\nWe revealed a cell autonomous
    requirement of WDFY3 for accurate laminar positioning of cortical projection neurons
    and elimination of mispositioned cells during early postnatal life. In addition,
    we identified significant deviations in dendritic arborization, as well as synaptic
    density and morphology between wild type, heterozygous, and homozygous Wdfy3 mutant
    neurons in Wdfy3-MADM reporter mice at postnatal stages. Limitations While Wdfy3
    mutant mice have provided valuable insight into prenatal aspects of ASD pathology
    that remain inaccessible to investigation in humans, like most animal models,
    they do not a perfectly replicate all aspects of human ASD biology. The lack of
    human data makes it indeterminate whether morphological deviations described here
    apply to ASD patients.\r\nConclusions\r\n\uFEFFOur genetic approach revealed several
    cell autonomous requirements of Wdfy3 in neuronal development that could underly
    the pathogenic mechanisms of WDFY3-related ASD conditions. The results are also
    consistent with findings in other ASD animal models and patients and suggest an
    important role for Wdfy3 in regulating neuronal function and interconnectivity
    in postnatal life."
article_processing_charge: No
author:
- first_name: Zachary
  full_name: Schaaf, Zachary
  last_name: Schaaf
- first_name: Lyvin
  full_name: Tat, Lyvin
  last_name: Tat
- first_name: Noemi
  full_name: Cannizzaro, Noemi
  last_name: Cannizzaro
- first_name: Ralph
  full_name: Green, Ralph
  last_name: Green
- first_name: Thomas
  full_name: Rülicke, Thomas
  last_name: Rülicke
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
- first_name: K
  full_name: Zarbalis, K
  last_name: Zarbalis
citation:
  ama: Schaaf Z, Tat L, Cannizzaro N, et al. WDFY3 cell autonomously controls neuronal
    migration. doi:<a href="https://doi.org/10.21203/rs.3.rs-1316167/v1">10.21203/rs.3.rs-1316167/v1</a>
  apa: Schaaf, Z., Tat, L., Cannizzaro, N., Green, R., Rülicke, T., Hippenmeyer, S.,
    &#38; Zarbalis, K. (n.d.). WDFY3 cell autonomously controls neuronal migration.
    Research Square. <a href="https://doi.org/10.21203/rs.3.rs-1316167/v1">https://doi.org/10.21203/rs.3.rs-1316167/v1</a>
  chicago: Schaaf, Zachary, Lyvin Tat, Noemi Cannizzaro, Ralph Green, Thomas Rülicke,
    Simon Hippenmeyer, and K Zarbalis. “WDFY3 Cell Autonomously Controls Neuronal
    Migration.” Research Square, n.d. <a href="https://doi.org/10.21203/rs.3.rs-1316167/v1">https://doi.org/10.21203/rs.3.rs-1316167/v1</a>.
  ieee: Z. Schaaf <i>et al.</i>, “WDFY3 cell autonomously controls neuronal migration.”
    Research Square.
  ista: Schaaf Z, Tat L, Cannizzaro N, Green R, Rülicke T, Hippenmeyer S, Zarbalis
    K. WDFY3 cell autonomously controls neuronal migration. <a href="https://doi.org/10.21203/rs.3.rs-1316167/v1">10.21203/rs.3.rs-1316167/v1</a>.
  mla: Schaaf, Zachary, et al. <i>WDFY3 Cell Autonomously Controls Neuronal Migration</i>.
    Research Square, doi:<a href="https://doi.org/10.21203/rs.3.rs-1316167/v1">10.21203/rs.3.rs-1316167/v1</a>.
  short: Z. Schaaf, L. Tat, N. Cannizzaro, R. Green, T. Rülicke, S. Hippenmeyer, K.
    Zarbalis, (n.d.).
date_created: 2022-02-25T07:53:26Z
date_published: 2022-02-16T00:00:00Z
date_updated: 2023-10-17T13:06:52Z
day: '16'
department:
- _id: SiHi
doi: 10.21203/rs.3.rs-1316167/v1
external_id:
  pmid:
  - PPR454733
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.21203/rs.3.rs-1316167/v1
month: '02'
oa: 1
oa_version: Preprint
page: '30'
pmid: 1
publication_identifier:
  eissn:
  - 2693-5015
publication_status: submitted
publisher: Research Square
status: public
title: WDFY3 cell autonomously controls neuronal migration
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2022'
...
---
_id: '9978'
abstract:
- lang: eng
  text: Redox mediators could catalyse otherwise slow and energy-inefficient cycling
    of Li-S and Li-O 2 batteries by shuttling electrons/holes between the electrode
    and the solid insulating storage materials. For mediators to work efficiently
    they need to oxidize the solid with fast kinetics yet the lowest possible overpotential.
    Here, we found that when the redox potentials of mediators are tuned via, e.g.,
    Li + concentration in the electrolyte, they exhibit distinct threshold potentials,
    where the kinetics accelerate several-fold within a range as small as 10 mV. This
    phenomenon is independent of types of mediators and electrolyte. The acceleration
    originates from the overpotentials required to activate fast Li + /e – extraction
    and the following chemical step at specific abundant surface facets. Efficient
    redox catalysis at insulating solids requires therefore carefully considering
    the surface conditions of the storage materials and electrolyte-dependent redox
    potentials, which may be tuned by salt concentrations or solvents.
acknowledgement: 'This work was financially supported by the National Natural Science
  Foundation of China (51773092, 21975124, 11874254, 51802187, U2030206). S.A.F. is
  indebted to IST Austria for support. '
article_processing_charge: No
author:
- first_name: Deqing
  full_name: Cao, Deqing
  last_name: Cao
- first_name: Xiaoxiao
  full_name: Shen, Xiaoxiao
  last_name: Shen
- first_name: Aiping
  full_name: Wang, Aiping
  last_name: Wang
- first_name: Fengjiao
  full_name: Yu, Fengjiao
  last_name: Yu
- first_name: Yuping
  full_name: Wu, Yuping
  last_name: Wu
- first_name: Siqi
  full_name: Shi, Siqi
  last_name: Shi
- first_name: Stefan Alexander
  full_name: Freunberger, Stefan Alexander
  id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
  last_name: Freunberger
  orcid: 0000-0003-2902-5319
- first_name: Yuhui
  full_name: Chen, Yuhui
  last_name: Chen
citation:
  ama: Cao D, Shen X, Wang A, et al. Sharp kinetic acceleration potentials during
    mediated redox catalysis of insulators. <i>Research Square</i>. doi:<a href="https://doi.org/10.21203/rs.3.rs-750965/v1">10.21203/rs.3.rs-750965/v1</a>
  apa: Cao, D., Shen, X., Wang, A., Yu, F., Wu, Y., Shi, S., … Chen, Y. (n.d.). Sharp
    kinetic acceleration potentials during mediated redox catalysis of insulators.
    <i>Research Square</i>. Research Square. <a href="https://doi.org/10.21203/rs.3.rs-750965/v1">https://doi.org/10.21203/rs.3.rs-750965/v1</a>
  chicago: Cao, Deqing, Xiaoxiao Shen, Aiping Wang, Fengjiao Yu, Yuping Wu, Siqi Shi,
    Stefan Alexander Freunberger, and Yuhui Chen. “Sharp Kinetic Acceleration Potentials
    during Mediated Redox Catalysis of Insulators.” <i>Research Square</i>. Research
    Square, n.d. <a href="https://doi.org/10.21203/rs.3.rs-750965/v1">https://doi.org/10.21203/rs.3.rs-750965/v1</a>.
  ieee: D. Cao <i>et al.</i>, “Sharp kinetic acceleration potentials during mediated
    redox catalysis of insulators,” <i>Research Square</i>. Research Square.
  ista: Cao D, Shen X, Wang A, Yu F, Wu Y, Shi S, Freunberger SA, Chen Y. Sharp kinetic
    acceleration potentials during mediated redox catalysis of insulators. Research
    Square, <a href="https://doi.org/10.21203/rs.3.rs-750965/v1">10.21203/rs.3.rs-750965/v1</a>.
  mla: Cao, Deqing, et al. “Sharp Kinetic Acceleration Potentials during Mediated
    Redox Catalysis of Insulators.” <i>Research Square</i>, Research Square, doi:<a
    href="https://doi.org/10.21203/rs.3.rs-750965/v1">10.21203/rs.3.rs-750965/v1</a>.
  short: D. Cao, X. Shen, A. Wang, F. Yu, Y. Wu, S. Shi, S.A. Freunberger, Y. Chen,
    Research Square (n.d.).
date_created: 2021-08-31T12:54:16Z
date_published: 2021-08-18T00:00:00Z
date_updated: 2023-10-17T13:06:29Z
day: '18'
ddc:
- '541'
department:
- _id: StFr
doi: 10.21203/rs.3.rs-750965/v1
file:
- access_level: open_access
  checksum: 1878e91c29d5769ed5a827b0b7addf00
  content_type: application/pdf
  creator: cchlebak
  date_created: 2021-08-31T14:02:19Z
  date_updated: 2021-08-31T14:02:19Z
  file_id: '9979'
  file_name: 2021_ResearchSquare_Cao.pdf
  file_size: 1019662
  relation: main_file
  success: 1
file_date_updated: 2021-08-31T14:02:19Z
has_accepted_license: '1'
keyword:
- Catalysis
- Energy engineering
- Materials theory and modeling
language:
- iso: eng
month: '08'
oa: 1
oa_version: Preprint
page: '21'
publication: Research Square
publication_identifier:
  eissn:
  - 2693-5015
publication_status: submitted
publisher: Research Square
related_material:
  record:
  - id: '10813'
    relation: later_version
    status: public
status: public
title: Sharp kinetic acceleration potentials during mediated redox catalysis of insulators
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2021'
...