[{"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","status":"public","publication_identifier":{"eissn":["2522-5820"]},"date_published":"2023-07-01T00:00:00Z","type":"journal_article","language":[{"iso":"eng"}],"month":"07","oa_version":"None","publication":"Nature Reviews Physics","acknowledgement":"The authors acknowledge support from the Institute for the Physics of Living Systems, University College London (T.C.T.M.), the Swedish Research Council (2015-00143) (S.L.), the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013) through the ERC grant PhysProt (agreement no. 337969) (T.P.J.K.), the BBSRC (T.P.J.K.), the Newman Foundation (T.P.J.K.) and the Wellcome Trust Collaborative Award 203249/Z/16/Z (T.P.J.K.). The authors thank C. Flandoli for help with illustrations.","volume":5,"abstract":[{"lang":"eng","text":"The formation of amyloid fibrils is a general class of protein self-assembly behaviour, which is associated with both functional biology and the development of a number of disorders, such as Alzheimer and Parkinson diseases. In this Review, we discuss how general physical concepts from the study of phase transitions can be used to illuminate the fundamental mechanisms of amyloid self-assembly. We summarize progress in the efforts to describe the essential biophysical features of amyloid self-assembly as a nucleation-and-growth process and discuss how master equation approaches can reveal the key molecular pathways underlying this process, including the role of secondary nucleation. Additionally, we outline how non-classical aspects of aggregate formation involving oligomers or biomolecular condensates have emerged, inspiring developments in understanding, modelling and modulating complex protein assembly pathways. Finally, we consider how these concepts can be applied to kinetics-based drug discovery and therapeutic design to develop treatments for protein aggregation diseases."}],"doi":"10.1038/s42254-023-00598-9","day":"01","isi":1,"external_id":{"isi":["001017539800001"]},"date_updated":"2023-08-02T06:28:38Z","year":"2023","citation":{"apa":"Michaels, T. C. T., Qian, D., Šarić, A., Vendruscolo, M., Linse, S., &#38; Knowles, T. P. J. (2023). Amyloid formation as a protein phase transition. <i>Nature Reviews Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s42254-023-00598-9\">https://doi.org/10.1038/s42254-023-00598-9</a>","ama":"Michaels TCT, Qian D, Šarić A, Vendruscolo M, Linse S, Knowles TPJ. Amyloid formation as a protein phase transition. <i>Nature Reviews Physics</i>. 2023;5:379–397. doi:<a href=\"https://doi.org/10.1038/s42254-023-00598-9\">10.1038/s42254-023-00598-9</a>","chicago":"Michaels, Thomas C.T., Daoyuan Qian, Anđela Šarić, Michele Vendruscolo, Sara Linse, and Tuomas P.J. Knowles. “Amyloid Formation as a Protein Phase Transition.” <i>Nature Reviews Physics</i>. Springer Nature, 2023. <a href=\"https://doi.org/10.1038/s42254-023-00598-9\">https://doi.org/10.1038/s42254-023-00598-9</a>.","ieee":"T. C. T. Michaels, D. Qian, A. Šarić, M. Vendruscolo, S. Linse, and T. P. J. Knowles, “Amyloid formation as a protein phase transition,” <i>Nature Reviews Physics</i>, vol. 5. Springer Nature, pp. 379–397, 2023.","mla":"Michaels, Thomas C. T., et al. “Amyloid Formation as a Protein Phase Transition.” <i>Nature Reviews Physics</i>, vol. 5, Springer Nature, 2023, pp. 379–397, doi:<a href=\"https://doi.org/10.1038/s42254-023-00598-9\">10.1038/s42254-023-00598-9</a>.","short":"T.C.T. Michaels, D. Qian, A. Šarić, M. Vendruscolo, S. Linse, T.P.J. Knowles, Nature Reviews Physics 5 (2023) 379–397.","ista":"Michaels TCT, Qian D, Šarić A, Vendruscolo M, Linse S, Knowles TPJ. 2023. Amyloid formation as a protein phase transition. Nature Reviews Physics. 5, 379–397."},"article_type":"original","publisher":"Springer Nature","page":"379–397","quality_controlled":"1","title":"Amyloid formation as a protein phase transition","intvolume":"         5","publication_status":"published","date_created":"2023-07-16T22:01:12Z","department":[{"_id":"AnSa"}],"article_processing_charge":"No","author":[{"first_name":"Thomas C.T.","last_name":"Michaels","full_name":"Michaels, Thomas C.T."},{"first_name":"Daoyuan","last_name":"Qian","full_name":"Qian, Daoyuan"},{"first_name":"Anđela","last_name":"Šarić","orcid":"0000-0002-7854-2139","full_name":"Šarić, Anđela","id":"bf63d406-f056-11eb-b41d-f263a6566d8b"},{"full_name":"Vendruscolo, Michele","first_name":"Michele","last_name":"Vendruscolo"},{"full_name":"Linse, Sara","last_name":"Linse","first_name":"Sara"},{"first_name":"Tuomas P.J.","last_name":"Knowles","full_name":"Knowles, Tuomas P.J."}],"_id":"13237","scopus_import":"1"},{"publisher":"Springer Nature","article_type":"original","quality_controlled":"1","page":"62-72","article_processing_charge":"No","date_created":"2023-01-12T12:10:18Z","department":[{"_id":"BjHo"}],"publication_status":"published","intvolume":"         5","title":"Directed percolation and the transition to turbulence","scopus_import":"1","_id":"12165","author":[{"id":"3A374330-F248-11E8-B48F-1D18A9856A87","full_name":"Hof, Björn","orcid":"0000-0003-2057-2754","last_name":"Hof","first_name":"Björn"}],"volume":5,"day":"01","doi":"10.1038/s42254-022-00539-y","abstract":[{"text":"It may come as a surprise that a phenomenon as ubiquitous and prominent as the transition from laminar to turbulent flow has resisted combined efforts by physicists, engineers and mathematicians, and remained unresolved for almost one and a half centuries. In recent years, various studies have proposed analogies to directed percolation, a well-known universality class in statistical mechanics, which describes a non-equilibrium phase transition from a fluctuating active phase into an absorbing state. It is this unlikely relation between the multiscale, high-dimensional dynamics that signify the transition process in virtually all flows of practical relevance, and the arguably most basic non-equilibrium phase transition, that so far has mainly been the subject of model studies, which I review in this Perspective.","lang":"eng"}],"citation":{"chicago":"Hof, Björn. “Directed Percolation and the Transition to Turbulence.” <i>Nature Reviews Physics</i>. Springer Nature, 2023. <a href=\"https://doi.org/10.1038/s42254-022-00539-y\">https://doi.org/10.1038/s42254-022-00539-y</a>.","ieee":"B. Hof, “Directed percolation and the transition to turbulence,” <i>Nature Reviews Physics</i>, vol. 5. Springer Nature, pp. 62–72, 2023.","apa":"Hof, B. (2023). Directed percolation and the transition to turbulence. <i>Nature Reviews Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s42254-022-00539-y\">https://doi.org/10.1038/s42254-022-00539-y</a>","ama":"Hof B. Directed percolation and the transition to turbulence. <i>Nature Reviews Physics</i>. 2023;5:62-72. doi:<a href=\"https://doi.org/10.1038/s42254-022-00539-y\">10.1038/s42254-022-00539-y</a>","ista":"Hof B. 2023. Directed percolation and the transition to turbulence. Nature Reviews Physics. 5, 62–72.","mla":"Hof, Björn. “Directed Percolation and the Transition to Turbulence.” <i>Nature Reviews Physics</i>, vol. 5, Springer Nature, 2023, pp. 62–72, doi:<a href=\"https://doi.org/10.1038/s42254-022-00539-y\">10.1038/s42254-022-00539-y</a>.","short":"B. Hof, Nature Reviews Physics 5 (2023) 62–72."},"year":"2023","date_updated":"2023-08-01T12:50:48Z","external_id":{"isi":["000890148700002"]},"isi":1,"keyword":["General Physics and Astronomy"],"language":[{"iso":"eng"}],"oa_version":"None","month":"01","publication":"Nature Reviews Physics","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","status":"public","publication_identifier":{"eissn":["2522-5820"]},"type":"journal_article","date_published":"2023-01-01T00:00:00Z"}]