@article{13237,
  abstract     = {The formation of amyloid fibrils is a general class of protein self-assembly behaviour, which is associated with both functional biology and the development of a number of disorders, such as Alzheimer and Parkinson diseases. In this Review, we discuss how general physical concepts from the study of phase transitions can be used to illuminate the fundamental mechanisms of amyloid self-assembly. We summarize progress in the efforts to describe the essential biophysical features of amyloid self-assembly as a nucleation-and-growth process and discuss how master equation approaches can reveal the key molecular pathways underlying this process, including the role of secondary nucleation. Additionally, we outline how non-classical aspects of aggregate formation involving oligomers or biomolecular condensates have emerged, inspiring developments in understanding, modelling and modulating complex protein assembly pathways. Finally, we consider how these concepts can be applied to kinetics-based drug discovery and therapeutic design to develop treatments for protein aggregation diseases.},
  author       = {Michaels, Thomas C.T. and Qian, Daoyuan and Šarić, Anđela and Vendruscolo, Michele and Linse, Sara and Knowles, Tuomas P.J.},
  issn         = {2522-5820},
  journal      = {Nature Reviews Physics},
  pages        = {379–397},
  publisher    = {Springer Nature},
  title        = {{Amyloid formation as a protein phase transition}},
  doi          = {10.1038/s42254-023-00598-9},
  volume       = {5},
  year         = {2023},
}

@article{12165,
  abstract     = {It may come as a surprise that a phenomenon as ubiquitous and prominent as the transition from laminar to turbulent flow has resisted combined efforts by physicists, engineers and mathematicians, and remained unresolved for almost one and a half centuries. In recent years, various studies have proposed analogies to directed percolation, a well-known universality class in statistical mechanics, which describes a non-equilibrium phase transition from a fluctuating active phase into an absorbing state. It is this unlikely relation between the multiscale, high-dimensional dynamics that signify the transition process in virtually all flows of practical relevance, and the arguably most basic non-equilibrium phase transition, that so far has mainly been the subject of model studies, which I review in this Perspective.},
  author       = {Hof, Björn},
  issn         = {2522-5820},
  journal      = {Nature Reviews Physics},
  keywords     = {General Physics and Astronomy},
  pages        = {62--72},
  publisher    = {Springer Nature},
  title        = {{Directed percolation and the transition to turbulence}},
  doi          = {10.1038/s42254-022-00539-y},
  volume       = {5},
  year         = {2023},
}