---
_id: '13347'
abstract:
- lang: eng
  text: Confining molecules within well-defined nanosized spaces can profoundly alter
    their physicochemical characteristics. For example, the controlled aggregation
    of chromophores into discrete oligomers has been shown to tune their optical properties
    whereas encapsulation of reactive species within molecular hosts can increase
    their stability. The resazurin/resorufin pair has been widely used for detecting
    redox processes in biological settings; yet, how tight confinement affects the
    properties of these two dyes remains to be explored. Here, we show that a flexible
    Pd<jats:sup>II</jats:sup><jats:sub>6</jats:sub>L<jats:sub>4</jats:sub> coordination
    cage can efficiently encapsulate both resorufin and resazurin in the form of dimers,
    dramatically modulating their optical properties. Furthermore, binding within
    the cage significantly decreases the reduction rate of resazurin to resorufin,
    and the rate of the subsequent reduction of resorufin to dihydroresorufin. During
    our studies, we also found that upon dilution, the Pd<jats:sup>II</jats:sup><jats:sub>6</jats:sub>L<jats:sub>4</jats:sub>
    cage disassembles to afford Pd<jats:sup>II</jats:sup><jats:sub>2</jats:sub>L<jats:sub>2</jats:sub>
    species, which lacks the ability to form inclusion complexes – a process that
    can be reversed upon the addition of the strongly binding resorufin/resazurin
    guests. We expect that the herein disclosed ability of a water-soluble cage to
    reversibly modulate the optical and chemical properties of a molecular redox probe
    will expand the versatility of synthetic fluorescent probes in biologically relevant
    environments.
article_number: '44'
article_processing_charge: No
article_type: original
author:
- first_name: Oksana
  full_name: Yanshyna, Oksana
  last_name: Yanshyna
- first_name: Michał J.
  full_name: Białek, Michał J.
  last_name: Białek
- first_name: Oleg V.
  full_name: Chashchikhin, Oleg V.
  last_name: Chashchikhin
- first_name: Rafal
  full_name: Klajn, Rafal
  id: 8e84690e-1e48-11ed-a02b-a1e6fb8bb53b
  last_name: Klajn
citation:
  ama: Yanshyna O, Białek MJ, Chashchikhin OV, Klajn R. Encapsulation within a coordination
    cage modulates the reactivity of redox-active dyes. <i>Communications Chemistry</i>.
    2022;5. doi:<a href="https://doi.org/10.1038/s42004-022-00658-8">10.1038/s42004-022-00658-8</a>
  apa: Yanshyna, O., Białek, M. J., Chashchikhin, O. V., &#38; Klajn, R. (2022). Encapsulation
    within a coordination cage modulates the reactivity of redox-active dyes. <i>Communications
    Chemistry</i>. Springer Nature. <a href="https://doi.org/10.1038/s42004-022-00658-8">https://doi.org/10.1038/s42004-022-00658-8</a>
  chicago: Yanshyna, Oksana, Michał J. Białek, Oleg V. Chashchikhin, and Rafal Klajn.
    “Encapsulation within a Coordination Cage Modulates the Reactivity of Redox-Active
    Dyes.” <i>Communications Chemistry</i>. Springer Nature, 2022. <a href="https://doi.org/10.1038/s42004-022-00658-8">https://doi.org/10.1038/s42004-022-00658-8</a>.
  ieee: O. Yanshyna, M. J. Białek, O. V. Chashchikhin, and R. Klajn, “Encapsulation
    within a coordination cage modulates the reactivity of redox-active dyes,” <i>Communications
    Chemistry</i>, vol. 5. Springer Nature, 2022.
  ista: Yanshyna O, Białek MJ, Chashchikhin OV, Klajn R. 2022. Encapsulation within
    a coordination cage modulates the reactivity of redox-active dyes. Communications
    Chemistry. 5, 44.
  mla: Yanshyna, Oksana, et al. “Encapsulation within a Coordination Cage Modulates
    the Reactivity of Redox-Active Dyes.” <i>Communications Chemistry</i>, vol. 5,
    44, Springer Nature, 2022, doi:<a href="https://doi.org/10.1038/s42004-022-00658-8">10.1038/s42004-022-00658-8</a>.
  short: O. Yanshyna, M.J. Białek, O.V. Chashchikhin, R. Klajn, Communications Chemistry
    5 (2022).
date_created: 2023-08-01T09:30:47Z
date_published: 2022-03-30T00:00:00Z
date_updated: 2023-08-02T06:41:54Z
day: '30'
doi: 10.1038/s42004-022-00658-8
extern: '1'
intvolume: '         5'
keyword:
- Materials Chemistry
- Biochemistry
- Environmental Chemistry
- General Chemistry
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1038/s42004-022-00658-8
month: '03'
oa: 1
oa_version: Published Version
publication: Communications Chemistry
publication_identifier:
  eissn:
  - 2399-3669
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Encapsulation within a coordination cage modulates the reactivity of redox-active
  dyes
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5
year: '2022'
...