[{"volume":10,"acknowledgement":"This work is supported by the Max-Planck-Gesellschaft (MPG). We greatly appreciate computational resources from Deutsches Klimarechenzentrum (DKRZ) and the Jülich Supercomputing Centre (JSC). ICONA/O simulations are funded through the NextGEMS project by the EU’s Horizon 2020 programme (grant agreement no. 101003470). ICONA simulations are funded through the MONSOON-2.0 project (grant agreement no. 01LP1927A) which is supported from German Federal Ministry of Education and Research (BMBF). J.B. acknowledges funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant (grant agreement no. 101034413). B.S. acknowledges funding from the EU’s Horizon 2020 programme (grant agreement no. 101003470). C.M. gratefully acknowledges funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (Project CLUSTER, grant agreement no. 805041).","ddc":["550"],"year":"2024","citation":{"chicago":"Bao, Jiawei, Bjorn Stevens, Lukas Kluft, and Caroline J Muller. “Intensification of Daily Tropical Precipitation Extremes from More Organized Convection.” <i>Science Advances</i>. American Association for the Advancement of Science, 2024. <a href=\"https://doi.org/10.1126/sciadv.adj6801\">https://doi.org/10.1126/sciadv.adj6801</a>.","ieee":"J. Bao, B. Stevens, L. Kluft, and C. J. Muller, “Intensification of daily tropical precipitation extremes from more organized convection,” <i>Science Advances</i>, vol. 10, no. 8. American Association for the Advancement of Science, 2024.","apa":"Bao, J., Stevens, B., Kluft, L., &#38; Muller, C. J. (2024). Intensification of daily tropical precipitation extremes from more organized convection. <i>Science Advances</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/sciadv.adj6801\">https://doi.org/10.1126/sciadv.adj6801</a>","ama":"Bao J, Stevens B, Kluft L, Muller CJ. Intensification of daily tropical precipitation extremes from more organized convection. <i>Science Advances</i>. 2024;10(8). doi:<a href=\"https://doi.org/10.1126/sciadv.adj6801\">10.1126/sciadv.adj6801</a>","ista":"Bao J, Stevens B, Kluft L, Muller CJ. 2024. Intensification of daily tropical precipitation extremes from more organized convection. Science Advances. 10(8), eadj6801.","short":"J. Bao, B. Stevens, L. Kluft, C.J. Muller, Science Advances 10 (2024).","mla":"Bao, Jiawei, et al. “Intensification of Daily Tropical Precipitation Extremes from More Organized Convection.” <i>Science Advances</i>, vol. 10, no. 8, eadj6801, American Association for the Advancement of Science, 2024, doi:<a href=\"https://doi.org/10.1126/sciadv.adj6801\">10.1126/sciadv.adj6801</a>."},"date_updated":"2024-03-05T09:26:47Z","external_id":{"pmid":["38394192"]},"day":"23","doi":"10.1126/sciadv.adj6801","abstract":[{"text":"Tropical precipitation extremes and their changes with surface warming are investigated using global storm resolving simulations and high-resolution observations. The simulations demonstrate that the mesoscale organization of convection, a process that cannot be physically represented by conventional global climate models, is important for the variations of tropical daily accumulated precipitation extremes. In both the simulations and observations, daily precipitation extremes increase in a more organized state, in association with larger, but less frequent, storms. Repeating the simulations for a warmer climate results in a robust increase in monthly-mean daily precipitation extremes. Higher precipitation percentiles have a greater sensitivity to convective organization, which is predicted to increase with warming. Without changes in organization, the strongest daily precipitation extremes over the tropical oceans increase at a rate close to Clausius-Clapeyron (CC) scaling. Thus, in a future warmer state with increased organization, the strongest daily precipitation extremes over oceans increase at a faster rate than CC scaling.","lang":"eng"}],"quality_controlled":"1","ec_funded":1,"file_date_updated":"2024-03-04T07:34:00Z","publisher":"American Association for the Advancement of Science","article_type":"original","scopus_import":"1","pmid":1,"_id":"15047","issue":"8","author":[{"full_name":"Bao, Jiawei","first_name":"Jiawei","last_name":"Bao","id":"bb9a7399-fefd-11ed-be3c-ae648fd1d160"},{"last_name":"Stevens","first_name":"Bjorn","full_name":"Stevens, Bjorn"},{"first_name":"Lukas","last_name":"Kluft","full_name":"Kluft, Lukas"},{"id":"f978ccb0-3f7f-11eb-b193-b0e2bd13182b","last_name":"Muller","first_name":"Caroline J","full_name":"Muller, Caroline J","orcid":"0000-0001-5836-5350"}],"department":[{"_id":"CaMu"}],"date_created":"2024-03-03T23:00:50Z","article_processing_charge":"Yes","publication_status":"published","intvolume":"        10","title":"Intensification of daily tropical precipitation extremes from more organized convection","file":[{"date_updated":"2024-03-04T07:34:00Z","content_type":"application/pdf","file_name":"2024_ScienceAdv_Bao.pdf","date_created":"2024-03-04T07:34:00Z","checksum":"d4ec4f05a6d14745057e14d1b8bf45ae","file_size":800926,"file_id":"15051","creator":"dernst","relation":"main_file","success":1,"access_level":"open_access"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","related_material":{"link":[{"description":"News on ISTA Website","relation":"press_release","url":"https://ista.ac.at/en/news/cloud-clustering-causes-more-extreme-rain/"}]},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"type":"journal_article","date_published":"2024-02-23T00:00:00Z","publication_identifier":{"eissn":["2375-2548"]},"oa":1,"language":[{"iso":"eng"}],"has_accepted_license":"1","publication":"Science Advances","project":[{"grant_number":"101034413","name":"IST-BRIDGE: International postdoctoral program","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","call_identifier":"H2020"},{"_id":"629205d8-2b32-11ec-9570-e1356ff73576","call_identifier":"H2020","name":"organization of CLoUdS, and implications of Tropical  cyclones and for the Energetics of the tropics, in current and waRming climate","grant_number":"805041"}],"oa_version":"Published Version","article_number":"eadj6801","month":"02"},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","file":[{"success":1,"access_level":"open_access","relation":"main_file","file_id":"13338","creator":"dernst","date_created":"2023-08-01T06:40:35Z","file_size":1759993,"checksum":"f59217e1083767777318b5d0cc5e141d","date_updated":"2023-08-01T06:40:35Z","content_type":"application/pdf","file_name":"2023_ScienceAdvance_Ogura.pdf"}],"date_published":"2023-07-07T00:00:00Z","type":"journal_article","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"oa":1,"publication_identifier":{"eissn":["2375-2548"]},"language":[{"iso":"eng"}],"publication":"Science Advances","has_accepted_license":"1","month":"07","oa_version":"Published Version","ddc":["580"],"volume":9,"acknowledgement":"Wethank Y.Iwayama, K.Ohtawa, K.Fukumoto,andN. Mataga (RIKENRRD) for technical assistance in Quartz-Seq2analyses; M. Mouri(RIKENCSRS)for technical support with plasmid construction and transactivation assay; Y. Ikeda (NAIST) for technical support with tissue culture; and A. Furuta for technical support in bulk RNA-seq analysis. We also thank the Single-cell Omics Laboratory for technical consultation in scRNA-seq analyses, the members of the Laboratory for Bioinformatics Research at the RIKEN Center for Biosystems Dynamics Research, and A. Matsushima and T. Ichikawa for IT infrastructure management. This work was supported by JSPS KAKENHI(17K15146,19H05670,20K06712,20H04894,20H05431,and 22H04713 to M.I. and 20H03284 and 20H05911 to K.S.), by the JST FOREST Program (JPMJFR214H to M.I.), by The Naito Foundation to M.I.; by Takeda Science Foundation to M.I,and by the Shiseido Female Researcher Science Grant to M.I. This work was partially supported by RIKENE pigenome Control Program, Medical Research Center Initiative for High Depth Omics, and JST CREST(JPMJCR16G3and JPMJCR1926)to I.N.","isi":1,"external_id":{"isi":["001030983100012"],"pmid":["37418524"]},"date_updated":"2023-12-13T11:59:29Z","citation":{"apa":"Ogura, N., Sasagawa, Y., Ito, T., Tameshige, T., Kawai, S., Sano, M., … Ikeuchi, M. (2023). WUSCHEL-RELATED HOMEOBOX 13 suppresses de novo shoot regeneration via cell fate control of pluripotent callus. <i>Science Advances</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/sciadv.adg6983\">https://doi.org/10.1126/sciadv.adg6983</a>","ama":"Ogura N, Sasagawa Y, Ito T, et al. WUSCHEL-RELATED HOMEOBOX 13 suppresses de novo shoot regeneration via cell fate control of pluripotent callus. <i>Science Advances</i>. 2023;9(27):eadg6983. doi:<a href=\"https://doi.org/10.1126/sciadv.adg6983\">10.1126/sciadv.adg6983</a>","ieee":"N. Ogura <i>et al.</i>, “WUSCHEL-RELATED HOMEOBOX 13 suppresses de novo shoot regeneration via cell fate control of pluripotent callus,” <i>Science Advances</i>, vol. 9, no. 27. American Association for the Advancement of Science, p. eadg6983, 2023.","chicago":"Ogura, Nao, Yohei Sasagawa, Tasuku Ito, Toshiaki Tameshige, Satomi Kawai, Masaki Sano, Yuki Doll, et al. “WUSCHEL-RELATED HOMEOBOX 13 Suppresses de Novo Shoot Regeneration via Cell Fate Control of Pluripotent Callus.” <i>Science Advances</i>. American Association for the Advancement of Science, 2023. <a href=\"https://doi.org/10.1126/sciadv.adg6983\">https://doi.org/10.1126/sciadv.adg6983</a>.","short":"N. Ogura, Y. Sasagawa, T. Ito, T. Tameshige, S. Kawai, M. Sano, Y. Doll, A. Iwase, A. Kawamura, T. Suzuki, I. Nikaido, K. Sugimoto, M. Ikeuchi, Science Advances 9 (2023) eadg6983.","mla":"Ogura, Nao, et al. “WUSCHEL-RELATED HOMEOBOX 13 Suppresses de Novo Shoot Regeneration via Cell Fate Control of Pluripotent Callus.” <i>Science Advances</i>, vol. 9, no. 27, American Association for the Advancement of Science, 2023, p. eadg6983, doi:<a href=\"https://doi.org/10.1126/sciadv.adg6983\">10.1126/sciadv.adg6983</a>.","ista":"Ogura N, Sasagawa Y, Ito T, Tameshige T, Kawai S, Sano M, Doll Y, Iwase A, Kawamura A, Suzuki T, Nikaido I, Sugimoto K, Ikeuchi M. 2023. WUSCHEL-RELATED HOMEOBOX 13 suppresses de novo shoot regeneration via cell fate control of pluripotent callus. Science Advances. 9(27), eadg6983."},"year":"2023","abstract":[{"text":"Plants can regenerate their bodies via de novo establishment of shoot apical meristems (SAMs) from pluripotent callus. Only a small fraction of callus cells is eventually specified into SAMs but the molecular mechanisms underlying fate specification remain obscure. The expression of WUSCHEL (WUS) is an early hallmark of SAM fate acquisition. Here, we show that a WUS paralog, WUSCHEL-RELATED HOMEOBOX 13 (WOX13), negatively regulates SAM formation from callus in Arabidopsis thaliana. WOX13 promotes non-meristematic cell fate via transcriptional repression of WUS and other SAM regulators and activation of cell wall modifiers. Our Quartz-Seq2–based single cell transcriptome revealed that WOX13 plays key roles in determining cellular identity of callus cell population. We propose that reciprocal inhibition between WUS and WOX13 mediates critical cell fate determination in pluripotent cell population, which has a major impact on regeneration efficiency.","lang":"eng"}],"doi":"10.1126/sciadv.adg6983","day":"07","file_date_updated":"2023-08-01T06:40:35Z","page":"eadg6983","quality_controlled":"1","article_type":"original","publisher":"American Association for the Advancement of Science","author":[{"full_name":"Ogura, Nao","last_name":"Ogura","first_name":"Nao"},{"last_name":"Sasagawa","first_name":"Yohei","full_name":"Sasagawa, Yohei"},{"first_name":"Tasuku","last_name":"Ito","orcid":"0000-0002-2482-9089","full_name":"Ito, Tasuku","id":"d5a17a4a-e534-11eb-93ec-91fa2aa9bd57"},{"full_name":"Tameshige, Toshiaki","last_name":"Tameshige","first_name":"Toshiaki"},{"first_name":"Satomi","last_name":"Kawai","full_name":"Kawai, Satomi"},{"full_name":"Sano, Masaki","first_name":"Masaki","last_name":"Sano"},{"first_name":"Yuki","last_name":"Doll","full_name":"Doll, Yuki"},{"first_name":"Akira","last_name":"Iwase","full_name":"Iwase, Akira"},{"last_name":"Kawamura","first_name":"Ayako","full_name":"Kawamura, Ayako"},{"full_name":"Suzuki, Takamasa","last_name":"Suzuki","first_name":"Takamasa"},{"full_name":"Nikaido, Itoshi","first_name":"Itoshi","last_name":"Nikaido"},{"last_name":"Sugimoto","first_name":"Keiko","full_name":"Sugimoto, Keiko"},{"first_name":"Momoko","last_name":"Ikeuchi","full_name":"Ikeuchi, Momoko"}],"issue":"27","pmid":1,"_id":"13259","scopus_import":"1","title":"WUSCHEL-RELATED HOMEOBOX 13 suppresses de novo shoot regeneration via cell fate control of pluripotent callus","intvolume":"         9","publication_status":"published","article_processing_charge":"Yes","date_created":"2023-07-23T22:01:11Z"},{"language":[{"iso":"eng"}],"article_number":"eade5224","month":"03","project":[{"call_identifier":"H2020","_id":"eba2549b-77a9-11ec-83b8-a81e493eae4e","grant_number":"802960","name":"Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines"}],"oa_version":"Published Version","has_accepted_license":"1","publication":"Science Advances","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","status":"public","file":[{"date_updated":"2023-03-27T06:24:49Z","file_name":"2023_ScienceAdvances_Hurtig.pdf","content_type":"application/pdf","date_created":"2023-03-27T06:24:49Z","checksum":"6d7dbe9ed86a116c8a002d62971202c5","file_size":1826471,"file_id":"12768","creator":"dernst","success":1,"access_level":"open_access","relation":"main_file"}],"oa":1,"publication_identifier":{"eissn":["2375-2548"]},"type":"journal_article","date_published":"2023-03-17T00:00:00Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"article_type":"original","publisher":"American Association for the Advancement of Science","file_date_updated":"2023-03-27T06:24:49Z","quality_controlled":"1","ec_funded":1,"intvolume":"         9","title":"The patterned assembly and stepwise Vps4-mediated disassembly of composite ESCRT-III polymers drives archaeal cell division","date_created":"2023-03-26T22:01:06Z","article_processing_charge":"No","department":[{"_id":"AnSa"}],"publication_status":"published","issue":"11","author":[{"first_name":"Fredrik","last_name":"Hurtig","full_name":"Hurtig, Fredrik"},{"last_name":"Burgers","first_name":"Thomas C.Q.","full_name":"Burgers, Thomas C.Q."},{"last_name":"Cezanne","first_name":"Alice","full_name":"Cezanne, Alice"},{"full_name":"Jiang, Xiuyun","last_name":"Jiang","first_name":"Xiuyun"},{"full_name":"Mol, Frank N.","last_name":"Mol","first_name":"Frank N."},{"full_name":"Traparić, Jovan","last_name":"Traparić","first_name":"Jovan"},{"full_name":"Pulschen, Andre Arashiro","first_name":"Andre Arashiro","last_name":"Pulschen"},{"last_name":"Nierhaus","first_name":"Tim","full_name":"Nierhaus, Tim"},{"last_name":"Tarrason-Risa","first_name":"Gabriel","full_name":"Tarrason-Risa, Gabriel"},{"full_name":"Harker-Kirschneck, Lena","last_name":"Harker-Kirschneck","first_name":"Lena"},{"full_name":"Löwe, Jan","last_name":"Löwe","first_name":"Jan"},{"first_name":"Anđela","last_name":"Šarić","orcid":"0000-0002-7854-2139","full_name":"Šarić, Anđela","id":"bf63d406-f056-11eb-b41d-f263a6566d8b"},{"full_name":"Vlijm, Rifka","first_name":"Rifka","last_name":"Vlijm"},{"full_name":"Baum, Buzz","last_name":"Baum","first_name":"Buzz"}],"scopus_import":"1","_id":"12756","ddc":["570"],"acknowledgement":"We thank Y. Liu and V. Hale for help with electron cryotomography; the Medical Research Council (MRC) LMB Electron Microscopy Facility for access, training, and support; and T. Darling and J. Grimmett at the MRC LMB for help with computing infrastructure. We also thank the Flow Cytometry Facility and the MRC LMB for training and support.\r\n F.H. and G.T.-R. were supported by a grant from the Wellcome Trust (203276/Z/16/Z). A.C. was supported by an EMBO long-term fellowship: ALTF_1041-2021. J.T. was supported by a grant from the VW Foundation (94933). A.A.P. was supported by the Wellcome Trust (203276/Z/16/Z) and the HFSP (LT001027/2019). B.B. received support from the MRC LMB, the Wellcome Trust (203276/Z/16/Z), the VW Foundation (94933), the Life Sciences–Moore-Simons Foundation (735929LPI), and a Gordon and Betty Moore Foundation’s Symbiosis in Aquatic Systems Initiative (9346). A.Š. and X.J. acknowledge funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant no. 802960). L.H.-K. acknowledges support from Biotechnology and Biological Sciences Research Council LIDo Programme. T.N. and J.L. were supported by the MRC (U105184326) and the Wellcome Trust (203276/Z/16/Z).","volume":9,"abstract":[{"text":"ESCRT-III family proteins form composite polymers that deform and cut membrane tubes in the context of a wide range of cell biological processes across the tree of life. In reconstituted systems, sequential changes in the composition of ESCRT-III polymers induced by the AAA–adenosine triphosphatase Vps4 have been shown to remodel membranes. However, it is not known how composite ESCRT-III polymers are organized and remodeled in space and time in a cellular context. Taking advantage of the relative simplicity of the ESCRT-III–dependent division system in Sulfolobus acidocaldarius, one of the closest experimentally tractable prokaryotic relatives of eukaryotes, we use super-resolution microscopy, electron microscopy, and computational modeling to show how CdvB/CdvB1/CdvB2 proteins form a precisely patterned composite ESCRT-III division ring, which undergoes stepwise Vps4-dependent disassembly and contracts to cut cells into two. These observations lead us to suggest sequential changes in a patterned composite polymer as a general mechanism of ESCRT-III–dependent membrane remodeling.","lang":"eng"}],"day":"17","doi":"10.1126/sciadv.ade5224","external_id":{"isi":["000968083500010"]},"isi":1,"citation":{"short":"F. Hurtig, T.C.Q. Burgers, A. Cezanne, X. Jiang, F.N. Mol, J. Traparić, A.A. Pulschen, T. Nierhaus, G. Tarrason-Risa, L. Harker-Kirschneck, J. Löwe, A. Šarić, R. Vlijm, B. Baum, Science Advances 9 (2023).","mla":"Hurtig, Fredrik, et al. “The Patterned Assembly and Stepwise Vps4-Mediated Disassembly of Composite ESCRT-III Polymers Drives Archaeal Cell Division.” <i>Science Advances</i>, vol. 9, no. 11, eade5224, American Association for the Advancement of Science, 2023, doi:<a href=\"https://doi.org/10.1126/sciadv.ade5224\">10.1126/sciadv.ade5224</a>.","ista":"Hurtig F, Burgers TCQ, Cezanne A, Jiang X, Mol FN, Traparić J, Pulschen AA, Nierhaus T, Tarrason-Risa G, Harker-Kirschneck L, Löwe J, Šarić A, Vlijm R, Baum B. 2023. The patterned assembly and stepwise Vps4-mediated disassembly of composite ESCRT-III polymers drives archaeal cell division. Science Advances. 9(11), eade5224.","ama":"Hurtig F, Burgers TCQ, Cezanne A, et al. The patterned assembly and stepwise Vps4-mediated disassembly of composite ESCRT-III polymers drives archaeal cell division. <i>Science Advances</i>. 2023;9(11). doi:<a href=\"https://doi.org/10.1126/sciadv.ade5224\">10.1126/sciadv.ade5224</a>","apa":"Hurtig, F., Burgers, T. C. Q., Cezanne, A., Jiang, X., Mol, F. N., Traparić, J., … Baum, B. (2023). The patterned assembly and stepwise Vps4-mediated disassembly of composite ESCRT-III polymers drives archaeal cell division. <i>Science Advances</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/sciadv.ade5224\">https://doi.org/10.1126/sciadv.ade5224</a>","ieee":"F. Hurtig <i>et al.</i>, “The patterned assembly and stepwise Vps4-mediated disassembly of composite ESCRT-III polymers drives archaeal cell division,” <i>Science Advances</i>, vol. 9, no. 11. American Association for the Advancement of Science, 2023.","chicago":"Hurtig, Fredrik, Thomas C.Q. Burgers, Alice Cezanne, Xiuyun Jiang, Frank N. Mol, Jovan Traparić, Andre Arashiro Pulschen, et al. “The Patterned Assembly and Stepwise Vps4-Mediated Disassembly of Composite ESCRT-III Polymers Drives Archaeal Cell Division.” <i>Science Advances</i>. American Association for the Advancement of Science, 2023. <a href=\"https://doi.org/10.1126/sciadv.ade5224\">https://doi.org/10.1126/sciadv.ade5224</a>."},"year":"2023","date_updated":"2023-08-01T13:45:54Z"},{"doi":"10.1126/sciadv.abq2811","arxiv":1,"day":"15","abstract":[{"lang":"eng","text":"Understanding the chirality of molecular reaction pathways is essential for a broad range of fundamental and applied sciences. However, the current ability to probe chirality on the time scale of primary processes underlying chemical reactions remains very limited. Here, we demonstrate time-resolved photoelectron circular dichroism (TRPECD) with ultrashort circularly polarized vacuum-ultraviolet (VUV) pulses from a tabletop source. We demonstrate the capabilities of VUV-TRPECD by resolving the chirality changes in time during the photodissociation of atomic iodine from two chiral molecules. We identify several general key features of TRPECD, which include the ability to probe dynamical chirality along the complete photochemical reaction path, the sensitivity to the local chirality of the evolving scattering potential, and the influence of electron scattering off dissociating photofragments. Our results are interpreted by comparison with high-level ab-initio calculations of transient PECDs from molecular photoionization calculations. Our experimental and theoretical techniques define a general approach to femtochirality."}],"date_updated":"2023-08-22T07:24:01Z","citation":{"ista":"Svoboda V, Ram NB, Baykusheva DR, Zindel D, Waters MDJ, Spenger B, Ochsner M, Herburger H, Stohner J, Wörner HJ. 2022. Femtosecond photoelectron circular dichroism of chemical reactions. Science Advances. 8(28), abq2811.","mla":"Svoboda, Vít, et al. “Femtosecond Photoelectron Circular Dichroism of Chemical Reactions.” <i>Science Advances</i>, vol. 8, no. 28, abq2811, American Association for the Advancement of Science, 2022, doi:<a href=\"https://doi.org/10.1126/sciadv.abq2811\">10.1126/sciadv.abq2811</a>.","short":"V. Svoboda, N.B. Ram, D.R. Baykusheva, D. Zindel, M.D.J. Waters, B. Spenger, M. Ochsner, H. Herburger, J. Stohner, H.J. Wörner, Science Advances 8 (2022).","chicago":"Svoboda, Vít, Niraghatam Bhargava Ram, Denitsa Rangelova Baykusheva, Daniel Zindel, Max D. J. Waters, Benjamin Spenger, Manuel Ochsner, Holger Herburger, Jürgen Stohner, and Hans Jakob Wörner. “Femtosecond Photoelectron Circular Dichroism of Chemical Reactions.” <i>Science Advances</i>. American Association for the Advancement of Science, 2022. <a href=\"https://doi.org/10.1126/sciadv.abq2811\">https://doi.org/10.1126/sciadv.abq2811</a>.","ieee":"V. Svoboda <i>et al.</i>, “Femtosecond photoelectron circular dichroism of chemical reactions,” <i>Science Advances</i>, vol. 8, no. 28. American Association for the Advancement of Science, 2022.","ama":"Svoboda V, Ram NB, Baykusheva DR, et al. Femtosecond photoelectron circular dichroism of chemical reactions. <i>Science Advances</i>. 2022;8(28). doi:<a href=\"https://doi.org/10.1126/sciadv.abq2811\">10.1126/sciadv.abq2811</a>","apa":"Svoboda, V., Ram, N. B., Baykusheva, D. R., Zindel, D., Waters, M. D. J., Spenger, B., … Wörner, H. J. (2022). Femtosecond photoelectron circular dichroism of chemical reactions. <i>Science Advances</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/sciadv.abq2811\">https://doi.org/10.1126/sciadv.abq2811</a>"},"year":"2022","external_id":{"arxiv":["2206.04099"],"pmid":["35857523"]},"volume":8,"extern":"1","publication_status":"published","date_created":"2023-08-09T13:08:04Z","article_processing_charge":"No","title":"Femtosecond photoelectron circular dichroism of chemical reactions","intvolume":"         8","pmid":1,"_id":"13992","scopus_import":"1","author":[{"first_name":"Vít","last_name":"Svoboda","full_name":"Svoboda, Vít"},{"full_name":"Ram, Niraghatam Bhargava","last_name":"Ram","first_name":"Niraghatam Bhargava"},{"id":"71b4d059-2a03-11ee-914d-dfa3beed6530","last_name":"Baykusheva","first_name":"Denitsa Rangelova","full_name":"Baykusheva, Denitsa Rangelova"},{"full_name":"Zindel, Daniel","first_name":"Daniel","last_name":"Zindel"},{"last_name":"Waters","first_name":"Max D. J.","full_name":"Waters, Max D. J."},{"first_name":"Benjamin","last_name":"Spenger","full_name":"Spenger, Benjamin"},{"first_name":"Manuel","last_name":"Ochsner","full_name":"Ochsner, Manuel"},{"full_name":"Herburger, Holger","last_name":"Herburger","first_name":"Holger"},{"last_name":"Stohner","first_name":"Jürgen","full_name":"Stohner, Jürgen"},{"full_name":"Wörner, Hans Jakob","first_name":"Hans Jakob","last_name":"Wörner"}],"issue":"28","publisher":"American Association for the Advancement of Science","article_type":"original","quality_controlled":"1","publication_identifier":{"eissn":["2375-2548"]},"oa":1,"date_published":"2022-07-15T00:00:00Z","type":"journal_article","main_file_link":[{"url":"https://doi.org/10.1126/sciadv.abq2811","open_access":"1"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","oa_version":"Published Version","month":"07","article_number":"abq2811","publication":"Science Advances","language":[{"iso":"eng"}],"keyword":["Multidisciplinary"]},{"article_type":"original","publisher":"American Association for the Advancement of Science","quality_controlled":"1","title":"Attosecond interferometry of shape resonances in the recoil frame of CF4","intvolume":"         7","publication_status":"published","date_created":"2023-08-09T13:09:02Z","article_processing_charge":"No","author":[{"last_name":"Heck","first_name":"Saijoscha","full_name":"Heck, Saijoscha"},{"first_name":"Denitsa Rangelova","last_name":"Baykusheva","full_name":"Baykusheva, Denitsa Rangelova","id":"71b4d059-2a03-11ee-914d-dfa3beed6530"},{"full_name":"Han, Meng","first_name":"Meng","last_name":"Han"},{"full_name":"Ji, Jia-Bao","last_name":"Ji","first_name":"Jia-Bao"},{"full_name":"Perry, Conaill","first_name":"Conaill","last_name":"Perry"},{"first_name":"Xiaochun","last_name":"Gong","full_name":"Gong, Xiaochun"},{"first_name":"Hans Jakob","last_name":"Wörner","full_name":"Wörner, Hans Jakob"}],"issue":"49","pmid":1,"_id":"13995","scopus_import":"1","extern":"1","volume":7,"abstract":[{"lang":"eng","text":"Shape resonances play a central role in many areas of science, but the real-time measurement of the associated many-body dynamics remains challenging. Here, we present measurements of recoil frame angle-resolved photoionization delays in the vicinity of shape resonances of CF4. This technique provides insights into the spatiotemporal photoionization dynamics of molecular shape resonances. We find delays of up to ∼600 as in the ionization out of the highest occupied molecular orbital (HOMO) with a strong dependence on the emission direction and a pronounced asymmetry along the dissociation axis. Comparison with quantum-scattering calculations traces the asymmetries to the interference of a small subset of partial waves at low kinetic energies and, additionally, to the interference of two overlapping shape resonances in the HOMO-1 channel. Our experimental and theoretical results establish a broadly applicable approach to space- and time-resolved photoionization dynamics in the molecular frame."}],"doi":"10.1126/sciadv.abj8121","day":"03","external_id":{"pmid":["34860540"]},"date_updated":"2023-08-22T07:30:25Z","citation":{"chicago":"Heck, Saijoscha, Denitsa Rangelova Baykusheva, Meng Han, Jia-Bao Ji, Conaill Perry, Xiaochun Gong, and Hans Jakob Wörner. “Attosecond Interferometry of Shape Resonances in the Recoil Frame of CF4.” <i>Science Advances</i>. American Association for the Advancement of Science, 2021. <a href=\"https://doi.org/10.1126/sciadv.abj8121\">https://doi.org/10.1126/sciadv.abj8121</a>.","ieee":"S. Heck <i>et al.</i>, “Attosecond interferometry of shape resonances in the recoil frame of CF4,” <i>Science Advances</i>, vol. 7, no. 49. American Association for the Advancement of Science, 2021.","ama":"Heck S, Baykusheva DR, Han M, et al. Attosecond interferometry of shape resonances in the recoil frame of CF4. <i>Science Advances</i>. 2021;7(49). doi:<a href=\"https://doi.org/10.1126/sciadv.abj8121\">10.1126/sciadv.abj8121</a>","apa":"Heck, S., Baykusheva, D. R., Han, M., Ji, J.-B., Perry, C., Gong, X., &#38; Wörner, H. J. (2021). Attosecond interferometry of shape resonances in the recoil frame of CF4. <i>Science Advances</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/sciadv.abj8121\">https://doi.org/10.1126/sciadv.abj8121</a>","ista":"Heck S, Baykusheva DR, Han M, Ji J-B, Perry C, Gong X, Wörner HJ. 2021. Attosecond interferometry of shape resonances in the recoil frame of CF4. Science Advances. 7(49), abj8121.","mla":"Heck, Saijoscha, et al. “Attosecond Interferometry of Shape Resonances in the Recoil Frame of CF4.” <i>Science Advances</i>, vol. 7, no. 49, abj8121, American Association for the Advancement of Science, 2021, doi:<a href=\"https://doi.org/10.1126/sciadv.abj8121\">10.1126/sciadv.abj8121</a>.","short":"S. Heck, D.R. Baykusheva, M. Han, J.-B. Ji, C. Perry, X. Gong, H.J. Wörner, Science Advances 7 (2021)."},"year":"2021","language":[{"iso":"eng"}],"keyword":["Multidisciplinary"],"month":"12","article_number":"abj8121","oa_version":"Published Version","publication":"Science Advances","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","main_file_link":[{"url":"https://doi.org/10.1126/sciadv.abj8121","open_access":"1"}],"oa":1,"publication_identifier":{"eissn":["2375-2548"]},"date_published":"2021-12-03T00:00:00Z","type":"journal_article"},{"pmid":1,"_id":"8986","scopus_import":"1","author":[{"last_name":"Zhang","first_name":"Yuzhou","full_name":"Zhang, Yuzhou","orcid":"0000-0003-2627-6956","id":"3B6137F2-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0002-7244-7237","full_name":"Rodriguez Solovey, Lesia","first_name":"Lesia","last_name":"Rodriguez Solovey","id":"3922B506-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Li, Lanxin","orcid":"0000-0002-5607-272X","last_name":"Li","first_name":"Lanxin","id":"367EF8FA-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Xixi","last_name":"Zhang","orcid":"0000-0001-7048-4627","full_name":"Zhang, Xixi","id":"61A66458-47E9-11EA-85BA-8AEAAF14E49A"},{"orcid":"0000-0002-8302-7596","full_name":"Friml, Jiří","first_name":"Jiří","last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87"}],"issue":"50","publication_status":"published","date_created":"2021-01-03T23:01:23Z","department":[{"_id":"JiFr"}],"article_processing_charge":"No","title":"Functional innovations of PIN auxin transporters mark crucial evolutionary transitions during rise of flowering plants","intvolume":"         6","quality_controlled":"1","ec_funded":1,"file_date_updated":"2021-01-07T12:44:33Z","publisher":"AAAS","article_type":"original","date_updated":"2024-10-29T10:22:43Z","year":"2020","citation":{"chicago":"Zhang, Yuzhou, Lesia Rodriguez Solovey, Lanxin Li, Xixi Zhang, and Jiří Friml. “Functional Innovations of PIN Auxin Transporters Mark Crucial Evolutionary Transitions during Rise of Flowering Plants.” <i>Science Advances</i>. AAAS, 2020. <a href=\"https://doi.org/10.1126/sciadv.abc8895\">https://doi.org/10.1126/sciadv.abc8895</a>.","ieee":"Y. Zhang, L. Rodriguez Solovey, L. Li, X. Zhang, and J. Friml, “Functional innovations of PIN auxin transporters mark crucial evolutionary transitions during rise of flowering plants,” <i>Science Advances</i>, vol. 6, no. 50. AAAS, 2020.","ama":"Zhang Y, Rodriguez Solovey L, Li L, Zhang X, Friml J. Functional innovations of PIN auxin transporters mark crucial evolutionary transitions during rise of flowering plants. <i>Science Advances</i>. 2020;6(50). doi:<a href=\"https://doi.org/10.1126/sciadv.abc8895\">10.1126/sciadv.abc8895</a>","apa":"Zhang, Y., Rodriguez Solovey, L., Li, L., Zhang, X., &#38; Friml, J. (2020). Functional innovations of PIN auxin transporters mark crucial evolutionary transitions during rise of flowering plants. <i>Science Advances</i>. AAAS. <a href=\"https://doi.org/10.1126/sciadv.abc8895\">https://doi.org/10.1126/sciadv.abc8895</a>","ista":"Zhang Y, Rodriguez Solovey L, Li L, Zhang X, Friml J. 2020. Functional innovations of PIN auxin transporters mark crucial evolutionary transitions during rise of flowering plants. Science Advances. 6(50), eabc8895.","mla":"Zhang, Yuzhou, et al. “Functional Innovations of PIN Auxin Transporters Mark Crucial Evolutionary Transitions during Rise of Flowering Plants.” <i>Science Advances</i>, vol. 6, no. 50, eabc8895, AAAS, 2020, doi:<a href=\"https://doi.org/10.1126/sciadv.abc8895\">10.1126/sciadv.abc8895</a>.","short":"Y. Zhang, L. Rodriguez Solovey, L. Li, X. Zhang, J. Friml, Science Advances 6 (2020)."},"isi":1,"external_id":{"isi":["000599903600014"],"pmid":["33310852"]},"doi":"10.1126/sciadv.abc8895","day":"11","abstract":[{"lang":"eng","text":"Flowering plants display the highest diversity among plant species and have notably shaped terrestrial landscapes. Nonetheless, the evolutionary origin of their unprecedented morphological complexity remains largely an enigma. Here, we show that the coevolution of cis-regulatory and coding regions of PIN-FORMED (PIN) auxin transporters confined their expression to certain cell types and directed their subcellular localization to particular cell sides, which together enabled dynamic auxin gradients across tissues critical to the complex architecture of flowering plants. Extensive intraspecies and interspecies genetic complementation experiments with PINs from green alga up to flowering plant lineages showed that PIN genes underwent three subsequent, critical evolutionary innovations and thus acquired a triple function to regulate the development of three essential components of the flowering plant Arabidopsis: shoot/root, inflorescence, and floral organ. Our work highlights the critical role of functional innovations within the PIN gene family as essential prerequisites for the origin of flowering plants."}],"acknowledgement":"We thank C.Löhne (Botanic Gardens, University of Bonn) for providing us with A. trichopoda. We would like to thank T.Han, A.Mally (IST, Austria), and C.Hartinger (University of Oxford) for constructive comment and careful reading. Funding: The research leading to these results has received funding from the European Union’s Horizon 2020 Research and Innovation Programme (ERC grant agreement number 742985), Austrian Science Fund (FWF, grant number I 3630-B25), DOC Fellowship of the Austrian Academy of Sciences, and IST Fellow program. ","volume":6,"ddc":["580"],"publication":"Science Advances","has_accepted_license":"1","oa_version":"Published Version","project":[{"grant_number":"742985","name":"Tracing Evolution of Auxin Transport and Polarity in Plants","call_identifier":"H2020","_id":"261099A6-B435-11E9-9278-68D0E5697425"},{"call_identifier":"FWF","_id":"26538374-B435-11E9-9278-68D0E5697425","grant_number":"I03630","name":"Molecular mechanisms of endocytic cargo recognition in plants"},{"_id":"26B4D67E-B435-11E9-9278-68D0E5697425","name":"A Case Study of Plant Growth Regulation: Molecular Mechanism of Auxin-mediated Rapid Growth Inhibition in Arabidopsis Root","grant_number":"25351"}],"month":"12","article_number":"eabc8895","language":[{"iso":"eng"}],"tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","image":"/images/cc_by_nc.png","short":"CC BY-NC (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode"},"date_published":"2020-12-11T00:00:00Z","type":"journal_article","publication_identifier":{"eissn":["2375-2548"]},"oa":1,"file":[{"checksum":"5ac2500b191c08ef6dab5327f40ff663","file_size":10578145,"date_created":"2021-01-07T12:44:33Z","content_type":"application/pdf","file_name":"2020_ScienceAdvances_Zhang.pdf","date_updated":"2021-01-07T12:44:33Z","relation":"main_file","access_level":"open_access","success":1,"creator":"dernst","file_id":"8994"}],"related_material":{"record":[{"id":"10083","relation":"dissertation_contains","status":"public"}]},"status":"public","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8"},{"citation":{"short":"S. Park, M. Artan, S.H. Han, H.-E.H. Park, Y. Jung, A.B. Hwang, W.S. Shin, K.-T. Kim, S.-J.V. Lee, Science Advances 6 (2020).","mla":"Park, Sangsoon, et al. “VRK-1 Extends Life Span by Activation of AMPK via Phosphorylation.” <i>Science Advances</i>, vol. 6, no. 27, aaw7824, American Association for the Advancement of Science, 2020, doi:<a href=\"https://doi.org/10.1126/sciadv.aaw7824\">10.1126/sciadv.aaw7824</a>.","ista":"Park S, Artan M, Han SH, Park H-EH, Jung Y, Hwang AB, Shin WS, Kim K-T, Lee S-JV. 2020. VRK-1 extends life span by activation of AMPK via phosphorylation. Science Advances. 6(27), aaw7824.","ama":"Park S, Artan M, Han SH, et al. VRK-1 extends life span by activation of AMPK via phosphorylation. <i>Science Advances</i>. 2020;6(27). doi:<a href=\"https://doi.org/10.1126/sciadv.aaw7824\">10.1126/sciadv.aaw7824</a>","apa":"Park, S., Artan, M., Han, S. H., Park, H.-E. H., Jung, Y., Hwang, A. B., … Lee, S.-J. V. (2020). VRK-1 extends life span by activation of AMPK via phosphorylation. <i>Science Advances</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/sciadv.aaw7824\">https://doi.org/10.1126/sciadv.aaw7824</a>","chicago":"Park, Sangsoon, Murat Artan, Seung Hyun Han, Hae-Eun H. Park, Yoonji Jung, Ara B. Hwang, Won Sik Shin, Kyong-Tai Kim, and Seung-Jae V. Lee. “VRK-1 Extends Life Span by Activation of AMPK via Phosphorylation.” <i>Science Advances</i>. American Association for the Advancement of Science, 2020. <a href=\"https://doi.org/10.1126/sciadv.aaw7824\">https://doi.org/10.1126/sciadv.aaw7824</a>.","ieee":"S. Park <i>et al.</i>, “VRK-1 extends life span by activation of AMPK via phosphorylation,” <i>Science Advances</i>, vol. 6, no. 27. American Association for the Advancement of Science, 2020."},"year":"2020","date_updated":"2024-03-04T09:52:09Z","day":"01","doi":"10.1126/sciadv.aaw7824","abstract":[{"text":"Vaccinia virus–related kinase (VRK) is an evolutionarily conserved nuclear protein kinase. VRK-1, the single Caenorhabditis elegans VRK ortholog, functions in cell division and germline proliferation. However, the role of VRK-1 in postmitotic cells and adult life span remains unknown. Here, we show that VRK-1 increases organismal longevity by activating the cellular energy sensor, AMP-activated protein kinase (AMPK), via direct phosphorylation. We found that overexpression of vrk-1 in the soma of adult C. elegans increased life span and, conversely, inhibition of vrk-1 decreased life span. In addition, vrk-1 was required for longevity conferred by mutations that inhibit C. elegans mitochondrial respiration, which requires AMPK. VRK-1 directly phosphorylated and up-regulated AMPK in both C. elegans and cultured human cells. Thus, our data show that the somatic nuclear kinase, VRK-1, promotes longevity through AMPK activation, and this function appears to be conserved between C. elegans and humans.","lang":"eng"}],"volume":6,"acknowledgement":"This research was supported by grants NRF-2019R1A3B2067745 and NRF-2017R1A5A1015366 funded by the Korean Government (MSIT) through the National Research Foundation (NRF) of Korea to S.-J.V.L. and by grant Basic Science Research Program (No. 2019R1A2C2009440) funded by the Korean Government (MSIT) through the NRF of Korea to K.-T.K. ","ddc":["570"],"_id":"15057","issue":"27","author":[{"full_name":"Park, Sangsoon","first_name":"Sangsoon","last_name":"Park"},{"id":"C407B586-6052-11E9-B3AE-7006E6697425","first_name":"Murat","last_name":"Artan","orcid":"0000-0001-8945-6992","full_name":"Artan, Murat"},{"last_name":"Han","first_name":"Seung Hyun","full_name":"Han, Seung Hyun"},{"first_name":"Hae-Eun H.","last_name":"Park","full_name":"Park, Hae-Eun H."},{"full_name":"Jung, Yoonji","last_name":"Jung","first_name":"Yoonji"},{"full_name":"Hwang, Ara B.","first_name":"Ara B.","last_name":"Hwang"},{"full_name":"Shin, Won Sik","last_name":"Shin","first_name":"Won Sik"},{"first_name":"Kyong-Tai","last_name":"Kim","full_name":"Kim, Kyong-Tai"},{"last_name":"Lee","first_name":"Seung-Jae V.","full_name":"Lee, Seung-Jae V."}],"article_processing_charge":"No","department":[{"_id":"MaDe"}],"date_created":"2024-03-04T09:41:57Z","publication_status":"published","intvolume":"         6","title":"VRK-1 extends life span by activation of AMPK via phosphorylation","quality_controlled":"1","file_date_updated":"2024-03-04T09:46:41Z","publisher":"American Association for the Advancement of Science","article_type":"original","tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","image":"/images/cc_by_nc.png","short":"CC BY-NC (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode"},"type":"journal_article","date_published":"2020-07-01T00:00:00Z","publication_identifier":{"eissn":["2375-2548"]},"oa":1,"file":[{"date_created":"2024-03-04T09:46:41Z","file_size":1864415,"checksum":"a37157cd0de709dce5fe03f4a31cd0b6","date_updated":"2024-03-04T09:46:41Z","file_name":"2020_ScienceAdvances_Park.pdf","content_type":"application/pdf","access_level":"open_access","success":1,"relation":"main_file","file_id":"15058","creator":"dernst"}],"status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","has_accepted_license":"1","publication":"Science Advances","oa_version":"Published Version","article_number":"aaw7824","month":"07","language":[{"iso":"eng"}]}]