@article{15047,
  abstract     = {Tropical precipitation extremes and their changes with surface warming are investigated using global storm resolving simulations and high-resolution observations. The simulations demonstrate that the mesoscale organization of convection, a process that cannot be physically represented by conventional global climate models, is important for the variations of tropical daily accumulated precipitation extremes. In both the simulations and observations, daily precipitation extremes increase in a more organized state, in association with larger, but less frequent, storms. Repeating the simulations for a warmer climate results in a robust increase in monthly-mean daily precipitation extremes. Higher precipitation percentiles have a greater sensitivity to convective organization, which is predicted to increase with warming. Without changes in organization, the strongest daily precipitation extremes over the tropical oceans increase at a rate close to Clausius-Clapeyron (CC) scaling. Thus, in a future warmer state with increased organization, the strongest daily precipitation extremes over oceans increase at a faster rate than CC scaling.},
  author       = {Bao, Jiawei and Stevens, Bjorn and Kluft, Lukas and Muller, Caroline J},
  issn         = {2375-2548},
  journal      = {Science Advances},
  number       = {8},
  publisher    = {American Association for the Advancement of Science},
  title        = {{Intensification of daily tropical precipitation extremes from more organized convection}},
  doi          = {10.1126/sciadv.adj6801},
  volume       = {10},
  year         = {2024},
}

@article{13259,
  abstract     = {Plants can regenerate their bodies via de novo establishment of shoot apical meristems (SAMs) from pluripotent callus. Only a small fraction of callus cells is eventually specified into SAMs but the molecular mechanisms underlying fate specification remain obscure. The expression of WUSCHEL (WUS) is an early hallmark of SAM fate acquisition. Here, we show that a WUS paralog, WUSCHEL-RELATED HOMEOBOX 13 (WOX13), negatively regulates SAM formation from callus in Arabidopsis thaliana. WOX13 promotes non-meristematic cell fate via transcriptional repression of WUS and other SAM regulators and activation of cell wall modifiers. Our Quartz-Seq2–based single cell transcriptome revealed that WOX13 plays key roles in determining cellular identity of callus cell population. We propose that reciprocal inhibition between WUS and WOX13 mediates critical cell fate determination in pluripotent cell population, which has a major impact on regeneration efficiency.},
  author       = {Ogura, Nao and Sasagawa, Yohei and Ito, Tasuku and Tameshige, Toshiaki and Kawai, Satomi and Sano, Masaki and Doll, Yuki and Iwase, Akira and Kawamura, Ayako and Suzuki, Takamasa and Nikaido, Itoshi and Sugimoto, Keiko and Ikeuchi, Momoko},
  issn         = {2375-2548},
  journal      = {Science Advances},
  number       = {27},
  pages        = {eadg6983},
  publisher    = {American Association for the Advancement of Science},
  title        = {{WUSCHEL-RELATED HOMEOBOX 13 suppresses de novo shoot regeneration via cell fate control of pluripotent callus}},
  doi          = {10.1126/sciadv.adg6983},
  volume       = {9},
  year         = {2023},
}

@article{12756,
  abstract     = {ESCRT-III family proteins form composite polymers that deform and cut membrane tubes in the context of a wide range of cell biological processes across the tree of life. In reconstituted systems, sequential changes in the composition of ESCRT-III polymers induced by the AAA–adenosine triphosphatase Vps4 have been shown to remodel membranes. However, it is not known how composite ESCRT-III polymers are organized and remodeled in space and time in a cellular context. Taking advantage of the relative simplicity of the ESCRT-III–dependent division system in Sulfolobus acidocaldarius, one of the closest experimentally tractable prokaryotic relatives of eukaryotes, we use super-resolution microscopy, electron microscopy, and computational modeling to show how CdvB/CdvB1/CdvB2 proteins form a precisely patterned composite ESCRT-III division ring, which undergoes stepwise Vps4-dependent disassembly and contracts to cut cells into two. These observations lead us to suggest sequential changes in a patterned composite polymer as a general mechanism of ESCRT-III–dependent membrane remodeling.},
  author       = {Hurtig, Fredrik and Burgers, Thomas C.Q. and Cezanne, Alice and Jiang, Xiuyun and Mol, Frank N. and Traparić, Jovan and Pulschen, Andre Arashiro and Nierhaus, Tim and Tarrason-Risa, Gabriel and Harker-Kirschneck, Lena and Löwe, Jan and Šarić, Anđela and Vlijm, Rifka and Baum, Buzz},
  issn         = {2375-2548},
  journal      = {Science Advances},
  number       = {11},
  publisher    = {American Association for the Advancement of Science},
  title        = {{The patterned assembly and stepwise Vps4-mediated disassembly of composite ESCRT-III polymers drives archaeal cell division}},
  doi          = {10.1126/sciadv.ade5224},
  volume       = {9},
  year         = {2023},
}

@article{13992,
  abstract     = {Understanding the chirality of molecular reaction pathways is essential for a broad range of fundamental and applied sciences. However, the current ability to probe chirality on the time scale of primary processes underlying chemical reactions remains very limited. Here, we demonstrate time-resolved photoelectron circular dichroism (TRPECD) with ultrashort circularly polarized vacuum-ultraviolet (VUV) pulses from a tabletop source. We demonstrate the capabilities of VUV-TRPECD by resolving the chirality changes in time during the photodissociation of atomic iodine from two chiral molecules. We identify several general key features of TRPECD, which include the ability to probe dynamical chirality along the complete photochemical reaction path, the sensitivity to the local chirality of the evolving scattering potential, and the influence of electron scattering off dissociating photofragments. Our results are interpreted by comparison with high-level ab-initio calculations of transient PECDs from molecular photoionization calculations. Our experimental and theoretical techniques define a general approach to femtochirality.},
  author       = {Svoboda, Vít and Ram, Niraghatam Bhargava and Baykusheva, Denitsa Rangelova and Zindel, Daniel and Waters, Max D. J. and Spenger, Benjamin and Ochsner, Manuel and Herburger, Holger and Stohner, Jürgen and Wörner, Hans Jakob},
  issn         = {2375-2548},
  journal      = {Science Advances},
  keywords     = {Multidisciplinary},
  number       = {28},
  publisher    = {American Association for the Advancement of Science},
  title        = {{Femtosecond photoelectron circular dichroism of chemical reactions}},
  doi          = {10.1126/sciadv.abq2811},
  volume       = {8},
  year         = {2022},
}

@article{13995,
  abstract     = {Shape resonances play a central role in many areas of science, but the real-time measurement of the associated many-body dynamics remains challenging. Here, we present measurements of recoil frame angle-resolved photoionization delays in the vicinity of shape resonances of CF4. This technique provides insights into the spatiotemporal photoionization dynamics of molecular shape resonances. We find delays of up to ∼600 as in the ionization out of the highest occupied molecular orbital (HOMO) with a strong dependence on the emission direction and a pronounced asymmetry along the dissociation axis. Comparison with quantum-scattering calculations traces the asymmetries to the interference of a small subset of partial waves at low kinetic energies and, additionally, to the interference of two overlapping shape resonances in the HOMO-1 channel. Our experimental and theoretical results establish a broadly applicable approach to space- and time-resolved photoionization dynamics in the molecular frame.},
  author       = {Heck, Saijoscha and Baykusheva, Denitsa Rangelova and Han, Meng and Ji, Jia-Bao and Perry, Conaill and Gong, Xiaochun and Wörner, Hans Jakob},
  issn         = {2375-2548},
  journal      = {Science Advances},
  keywords     = {Multidisciplinary},
  number       = {49},
  publisher    = {American Association for the Advancement of Science},
  title        = {{Attosecond interferometry of shape resonances in the recoil frame of CF4}},
  doi          = {10.1126/sciadv.abj8121},
  volume       = {7},
  year         = {2021},
}

@article{8986,
  abstract     = {Flowering plants display the highest diversity among plant species and have notably shaped terrestrial landscapes. Nonetheless, the evolutionary origin of their unprecedented morphological complexity remains largely an enigma. Here, we show that the coevolution of cis-regulatory and coding regions of PIN-FORMED (PIN) auxin transporters confined their expression to certain cell types and directed their subcellular localization to particular cell sides, which together enabled dynamic auxin gradients across tissues critical to the complex architecture of flowering plants. Extensive intraspecies and interspecies genetic complementation experiments with PINs from green alga up to flowering plant lineages showed that PIN genes underwent three subsequent, critical evolutionary innovations and thus acquired a triple function to regulate the development of three essential components of the flowering plant Arabidopsis: shoot/root, inflorescence, and floral organ. Our work highlights the critical role of functional innovations within the PIN gene family as essential prerequisites for the origin of flowering plants.},
  author       = {Zhang, Yuzhou and Rodriguez Solovey, Lesia and Li, Lanxin and Zhang, Xixi and Friml, Jiří},
  issn         = {2375-2548},
  journal      = {Science Advances},
  number       = {50},
  publisher    = {AAAS},
  title        = {{Functional innovations of PIN auxin transporters mark crucial evolutionary transitions during rise of flowering plants}},
  doi          = {10.1126/sciadv.abc8895},
  volume       = {6},
  year         = {2020},
}

@article{15057,
  abstract     = {Vaccinia virus–related kinase (VRK) is an evolutionarily conserved nuclear protein kinase. VRK-1, the single Caenorhabditis elegans VRK ortholog, functions in cell division and germline proliferation. However, the role of VRK-1 in postmitotic cells and adult life span remains unknown. Here, we show that VRK-1 increases organismal longevity by activating the cellular energy sensor, AMP-activated protein kinase (AMPK), via direct phosphorylation. We found that overexpression of vrk-1 in the soma of adult C. elegans increased life span and, conversely, inhibition of vrk-1 decreased life span. In addition, vrk-1 was required for longevity conferred by mutations that inhibit C. elegans mitochondrial respiration, which requires AMPK. VRK-1 directly phosphorylated and up-regulated AMPK in both C. elegans and cultured human cells. Thus, our data show that the somatic nuclear kinase, VRK-1, promotes longevity through AMPK activation, and this function appears to be conserved between C. elegans and humans.},
  author       = {Park, Sangsoon and Artan, Murat and Han, Seung Hyun and Park, Hae-Eun H. and Jung, Yoonji and Hwang, Ara B. and Shin, Won Sik and Kim, Kyong-Tai and Lee, Seung-Jae V.},
  issn         = {2375-2548},
  journal      = {Science Advances},
  number       = {27},
  publisher    = {American Association for the Advancement of Science},
  title        = {{VRK-1 extends life span by activation of AMPK via phosphorylation}},
  doi          = {10.1126/sciadv.aaw7824},
  volume       = {6},
  year         = {2020},
}