---
_id: '8579'
abstract:
- lang: eng
  text: Copper (Cu) is an essential trace element for all living organisms and used
    as cofactor in key enzymes of important biological processes, such as aerobic
    respiration or superoxide dismutation. However, due to its toxicity, cells have
    developed elaborate mechanisms for Cu homeostasis, which balance Cu supply for
    cuproprotein biogenesis with the need to remove excess Cu. This review summarizes
    our current knowledge on bacterial Cu homeostasis with a focus on Gram-negative
    bacteria and describes the multiple strategies that bacteria use for uptake, storage
    and export of Cu. We furthermore describe general mechanistic principles that
    aid the bacterial response to toxic Cu concentrations and illustrate dedicated
    Cu relay systems that facilitate Cu delivery for cuproenzyme biogenesis. Progress
    in understanding how bacteria avoid Cu poisoning while maintaining a certain Cu
    quota for cell proliferation is of particular importance for microbial pathogens
    because Cu is utilized by the host immune system for attenuating pathogen survival
    in host cells.
article_number: '242'
article_processing_charge: No
article_type: original
author:
- first_name: Andreea
  full_name: Andrei, Andreea
  last_name: Andrei
- first_name: Yavuz
  full_name: Öztürk, Yavuz
  last_name: Öztürk
- first_name: Bahia
  full_name: Khalfaoui-Hassani, Bahia
  last_name: Khalfaoui-Hassani
- first_name: Juna
  full_name: Rauch, Juna
  last_name: Rauch
- first_name: Dorian
  full_name: Marckmann, Dorian
  last_name: Marckmann
- first_name: Petru Iulian
  full_name: Trasnea, Petru Iulian
  id: D560034C-10C4-11EA-ABF4-A4B43DDC885E
  last_name: Trasnea
- first_name: Fevzi
  full_name: Daldal, Fevzi
  last_name: Daldal
- first_name: Hans-Georg
  full_name: Koch, Hans-Georg
  last_name: Koch
citation:
  ama: 'Andrei A, Öztürk Y, Khalfaoui-Hassani B, et al. Cu homeostasis in bacteria:
    The ins and outs. <i>Membranes</i>. 2020;10(9). doi:<a href="https://doi.org/10.3390/membranes10090242">10.3390/membranes10090242</a>'
  apa: 'Andrei, A., Öztürk, Y., Khalfaoui-Hassani, B., Rauch, J., Marckmann, D., Trasnea,
    P. I., … Koch, H.-G. (2020). Cu homeostasis in bacteria: The ins and outs. <i>Membranes</i>.
    MDPI. <a href="https://doi.org/10.3390/membranes10090242">https://doi.org/10.3390/membranes10090242</a>'
  chicago: 'Andrei, Andreea, Yavuz Öztürk, Bahia Khalfaoui-Hassani, Juna Rauch, Dorian
    Marckmann, Petru Iulian Trasnea, Fevzi Daldal, and Hans-Georg Koch. “Cu Homeostasis
    in Bacteria: The Ins and Outs.” <i>Membranes</i>. MDPI, 2020. <a href="https://doi.org/10.3390/membranes10090242">https://doi.org/10.3390/membranes10090242</a>.'
  ieee: 'A. Andrei <i>et al.</i>, “Cu homeostasis in bacteria: The ins and outs,”
    <i>Membranes</i>, vol. 10, no. 9. MDPI, 2020.'
  ista: 'Andrei A, Öztürk Y, Khalfaoui-Hassani B, Rauch J, Marckmann D, Trasnea PI,
    Daldal F, Koch H-G. 2020. Cu homeostasis in bacteria: The ins and outs. Membranes.
    10(9), 242.'
  mla: 'Andrei, Andreea, et al. “Cu Homeostasis in Bacteria: The Ins and Outs.” <i>Membranes</i>,
    vol. 10, no. 9, 242, MDPI, 2020, doi:<a href="https://doi.org/10.3390/membranes10090242">10.3390/membranes10090242</a>.'
  short: A. Andrei, Y. Öztürk, B. Khalfaoui-Hassani, J. Rauch, D. Marckmann, P.I.
    Trasnea, F. Daldal, H.-G. Koch, Membranes 10 (2020).
date_created: 2020-09-28T08:59:26Z
date_published: 2020-09-01T00:00:00Z
date_updated: 2023-08-22T09:34:06Z
day: '01'
ddc:
- '570'
department:
- _id: LeSa
doi: 10.3390/membranes10090242
external_id:
  isi:
  - '000581446000001'
file:
- access_level: open_access
  checksum: ceb43d7554e712dea6f36f9287271737
  content_type: application/pdf
  creator: dernst
  date_created: 2020-09-28T11:36:50Z
  date_updated: 2020-09-28T11:36:50Z
  file_id: '8583'
  file_name: 2020_Membranes_Andrei.pdf
  file_size: 4612258
  relation: main_file
  success: 1
file_date_updated: 2020-09-28T11:36:50Z
has_accepted_license: '1'
intvolume: '        10'
isi: 1
issue: '9'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '09'
oa: 1
oa_version: Published Version
publication: Membranes
publication_identifier:
  eissn:
  - '20770375'
publication_status: published
publisher: MDPI
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Cu homeostasis in bacteria: The ins and outs'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 10
year: '2020'
...