---
_id: '11986'
abstract:
- lang: eng
  text: Carbon nitride materials have emerged as an efficient and sustainable class
    of heterogeneous photocatalysts, particularly when paired with nickel in dual
    catalytic cross-coupling reactions. Performing these transformations on larger
    scales using a continuous process is difficult due to the problems associated
    with handling solids in flow. By combining an oscillatory pump with a microstructured
    plug flow photoreactor, a stable suspension of the photocatalyst can be maintained,
    circumventing clogging of the reactor channels. Through careful tuning of the
    oscillator properties, the residence time distribution (RTD) was optimized, whilst
    maintaining a stable catalyst suspension. Short residence times (20 min) were
    achieved using optimized conditions and the recyclability of the photocatalyst
    was demonstrated over 10 cycles with no loss of activity. During a stable 4.5
    hour scale-out demonstration, the model substrate could be isolated on 12 g scale
    (90% yield, 2.67 g h−1). Moreover, the method was applied for the gram scale synthesis
    of an intermediate of the active pharmaceutical ingredient tetracaine.
article_processing_charge: No
article_type: original
author:
- first_name: Cristian
  full_name: Rosso, Cristian
  last_name: Rosso
- first_name: Sebastian
  full_name: Gisbertz, Sebastian
  last_name: Gisbertz
- first_name: Jason D.
  full_name: Williams, Jason D.
  last_name: Williams
- first_name: Hannes P. L.
  full_name: Gemoets, Hannes P. L.
  last_name: Gemoets
- first_name: Wouter
  full_name: Debrouwer, Wouter
  last_name: Debrouwer
- first_name: Bartholomäus
  full_name: Pieber, Bartholomäus
  id: 93e5e5b2-0da6-11ed-8a41-af589a024726
  last_name: Pieber
  orcid: 0000-0001-8689-388X
- first_name: C. Oliver
  full_name: Kappe, C. Oliver
  last_name: Kappe
citation:
  ama: Rosso C, Gisbertz S, Williams JD, et al. An oscillatory plug flow photoreactor
    facilitates semi-heterogeneous dual nickel/carbon nitride photocatalytic C–N couplings.
    <i>Reaction Chemistry and Engineering</i>. 2020;5(3):597-604. doi:<a href="https://doi.org/10.1039/d0re00036a">10.1039/d0re00036a</a>
  apa: Rosso, C., Gisbertz, S., Williams, J. D., Gemoets, H. P. L., Debrouwer, W.,
    Pieber, B., &#38; Kappe, C. O. (2020). An oscillatory plug flow photoreactor facilitates
    semi-heterogeneous dual nickel/carbon nitride photocatalytic C–N couplings. <i>Reaction
    Chemistry and Engineering</i>. Royal Society of Chemistry. <a href="https://doi.org/10.1039/d0re00036a">https://doi.org/10.1039/d0re00036a</a>
  chicago: Rosso, Cristian, Sebastian Gisbertz, Jason D. Williams, Hannes P. L. Gemoets,
    Wouter Debrouwer, Bartholomäus Pieber, and C. Oliver Kappe. “An Oscillatory Plug
    Flow Photoreactor Facilitates Semi-Heterogeneous Dual Nickel/Carbon Nitride Photocatalytic
    C–N Couplings.” <i>Reaction Chemistry and Engineering</i>. Royal Society of Chemistry,
    2020. <a href="https://doi.org/10.1039/d0re00036a">https://doi.org/10.1039/d0re00036a</a>.
  ieee: C. Rosso <i>et al.</i>, “An oscillatory plug flow photoreactor facilitates
    semi-heterogeneous dual nickel/carbon nitride photocatalytic C–N couplings,” <i>Reaction
    Chemistry and Engineering</i>, vol. 5, no. 3. Royal Society of Chemistry, pp.
    597–604, 2020.
  ista: Rosso C, Gisbertz S, Williams JD, Gemoets HPL, Debrouwer W, Pieber B, Kappe
    CO. 2020. An oscillatory plug flow photoreactor facilitates semi-heterogeneous
    dual nickel/carbon nitride photocatalytic C–N couplings. Reaction Chemistry and
    Engineering. 5(3), 597–604.
  mla: Rosso, Cristian, et al. “An Oscillatory Plug Flow Photoreactor Facilitates
    Semi-Heterogeneous Dual Nickel/Carbon Nitride Photocatalytic C–N Couplings.” <i>Reaction
    Chemistry and Engineering</i>, vol. 5, no. 3, Royal Society of Chemistry, 2020,
    pp. 597–604, doi:<a href="https://doi.org/10.1039/d0re00036a">10.1039/d0re00036a</a>.
  short: C. Rosso, S. Gisbertz, J.D. Williams, H.P.L. Gemoets, W. Debrouwer, B. Pieber,
    C.O. Kappe, Reaction Chemistry and Engineering 5 (2020) 597–604.
date_created: 2022-08-25T11:45:02Z
date_published: 2020-03-01T00:00:00Z
date_updated: 2023-02-21T10:10:28Z
day: '01'
doi: 10.1039/d0re00036a
extern: '1'
intvolume: '         5'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1039/D0RE00036A
month: '03'
oa: 1
oa_version: Published Version
page: 597-604
publication: Reaction Chemistry and Engineering
publication_identifier:
  eissn:
  - 2058-9883
publication_status: published
publisher: Royal Society of Chemistry
quality_controlled: '1'
scopus_import: '1'
status: public
title: An oscillatory plug flow photoreactor facilitates semi-heterogeneous dual nickel/carbon
  nitride photocatalytic C–N couplings
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5
year: '2020'
...