---
_id: '10326'
abstract:
- lang: eng
  text: Strigolactones (SLs) are carotenoid-derived plant hormones that control shoot
    branching and communications between host plants and symbiotic fungi or root parasitic
    plants. Extensive studies have identified the key components participating in
    SL biosynthesis and signalling, whereas the catabolism or deactivation of endogenous
    SLs in planta remains largely unknown. Here, we report that the Arabidopsis carboxylesterase
    15 (AtCXE15) and its orthologues function as efficient hydrolases of SLs. We show
    that overexpression of AtCXE15 promotes shoot branching by dampening SL-inhibited
    axillary bud outgrowth. We further demonstrate that AtCXE15 could bind and efficiently
    hydrolyse SLs both in vitro and in planta. We also provide evidence that AtCXE15
    is capable of catalysing hydrolysis of diverse SL analogues and that such CXE15-dependent
    catabolism of SLs is evolutionarily conserved in seed plants. These results disclose
    a catalytic mechanism underlying homoeostatic regulation of SLs in plants, which
    also provides a rational approach to spatial-temporally manipulate the endogenous
    SLs and thus architecture of crops and ornamental plants.
acknowledgement: We thank J. Li (Institute of Genetics and Developmental Biology,
  China) for providing the at14-1, atmax2-1, atmax3-9, atmax4-1, atmax1-1, kai2-2
  (Col-0 background) mutants and B. Xu for providing the complementary DNA of P. patens.
  We are grateful to L. Wang for assistance with MST, B. Han for assistance with UPLC–MS,
  J. Li for assistance with confocal microscopy and B. Mikael and J. Zhang for their
  comments on the manuscript. This work was supported by grants from Strategic Priority
  Research Program of Chinese Academy of Sciences (Y.H., XDB27030102) and the National
  Natural Science Foundation of China (E.X., 31700253; Y.H., 31830055).
article_processing_charge: No
article_type: original
author:
- first_name: Enjun
  full_name: Xu, Enjun
  last_name: Xu
- first_name: Liang
  full_name: Chai, Liang
  last_name: Chai
- first_name: Shiqi
  full_name: Zhang, Shiqi
  last_name: Zhang
- first_name: Ruixue
  full_name: Yu, Ruixue
  last_name: Yu
- first_name: Xixi
  full_name: Zhang, Xixi
  id: 61A66458-47E9-11EA-85BA-8AEAAF14E49A
  last_name: Zhang
  orcid: 0000-0001-7048-4627
- first_name: Chongyi
  full_name: Xu, Chongyi
  last_name: Xu
- first_name: Yuxin
  full_name: Hu, Yuxin
  last_name: Hu
citation:
  ama: Xu E, Chai L, Zhang S, et al. Catabolism of strigolactones by a carboxylesterase.
    <i>Nature Plants</i>. 2021;7:1495–1504. doi:<a href="https://doi.org/10.1038/s41477-021-01011-y">10.1038/s41477-021-01011-y</a>
  apa: Xu, E., Chai, L., Zhang, S., Yu, R., Zhang, X., Xu, C., &#38; Hu, Y. (2021).
    Catabolism of strigolactones by a carboxylesterase. <i>Nature Plants</i>. Springer
    Nature. <a href="https://doi.org/10.1038/s41477-021-01011-y">https://doi.org/10.1038/s41477-021-01011-y</a>
  chicago: Xu, Enjun, Liang Chai, Shiqi Zhang, Ruixue Yu, Xixi Zhang, Chongyi Xu,
    and Yuxin Hu. “Catabolism of Strigolactones by a Carboxylesterase.” <i>Nature
    Plants</i>. Springer Nature, 2021. <a href="https://doi.org/10.1038/s41477-021-01011-y">https://doi.org/10.1038/s41477-021-01011-y</a>.
  ieee: E. Xu <i>et al.</i>, “Catabolism of strigolactones by a carboxylesterase,”
    <i>Nature Plants</i>, vol. 7. Springer Nature, pp. 1495–1504, 2021.
  ista: Xu E, Chai L, Zhang S, Yu R, Zhang X, Xu C, Hu Y. 2021. Catabolism of strigolactones
    by a carboxylesterase. Nature Plants. 7, 1495–1504.
  mla: Xu, Enjun, et al. “Catabolism of Strigolactones by a Carboxylesterase.” <i>Nature
    Plants</i>, vol. 7, Springer Nature, 2021, pp. 1495–1504, doi:<a href="https://doi.org/10.1038/s41477-021-01011-y">10.1038/s41477-021-01011-y</a>.
  short: E. Xu, L. Chai, S. Zhang, R. Yu, X. Zhang, C. Xu, Y. Hu, Nature Plants 7
    (2021) 1495–1504.
date_created: 2021-11-21T23:01:30Z
date_published: 2021-11-11T00:00:00Z
date_updated: 2023-08-14T11:54:02Z
day: '11'
department:
- _id: JiFr
doi: 10.1038/s41477-021-01011-y
external_id:
  isi:
  - '000717408000002'
  pmid:
  - '34764442'
intvolume: '         7'
isi: 1
language:
- iso: eng
month: '11'
oa_version: None
page: '1495–1504 '
pmid: 1
publication: Nature Plants
publication_identifier:
  eissn:
  - 2055-0278
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Catabolism of strigolactones by a carboxylesterase
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 7
year: '2021'
...