---
_id: '13166'
abstract:
- lang: eng
text: Brachyury, a member of T-box gene family, is widely known for its major role
in mesoderm specification in bilaterians. It is also present in non-bilaterian
metazoans, such as cnidarians, where it acts as a component of an axial patterning
system. In this study, we present a phylogenetic analysis of Brachyury genes within
phylum Cnidaria, investigate differential expression and address a functional
framework of Brachyury paralogs in hydrozoan Dynamena pumila. Our analysis indicates
two duplication events of Brachyury within the cnidarian lineage. The first duplication
likely appeared in the medusozoan ancestor, resulting in two copies in medusozoans,
while the second duplication arose in the hydrozoan ancestor, resulting in three
copies in hydrozoans. Brachyury1 and 2 display a conservative expression pattern
marking the oral pole of the body axis in D. pumila. On the contrary, Brachyury3
expression was detected in scattered presumably nerve cells of the D. pumila larva.
Pharmacological modulations indicated that Brachyury3 is not under regulation
of cWnt signaling in contrast to the other two Brachyury genes. Divergence in
expression patterns and regulation suggest neofunctionalization of Brachyury3
in hydrozoans.
acknowledgement: "We thank N.A. Pertsov White Sea Biological Station of Moscow State
University for the help and support in obtaining samples and providing access to
all required facilities and equipment of the “Center of Microscopy WSBS MSU”. We
are grateful to Dr. Amro Hamdoun for pCS2+8 plasmid (Addgene plasmid # 34931).\r\nWork
in the Walentek lab is supported by the Deutsche Forschungsgemeinschaft (DFG) under
the Emmy Noether Programme (grant WA3365/2-2) and under Germany’s Excellence Strategy
(CIBSS-EXC-2189-Project ID 390939984). SK is supported by the project No. 0088-2021-0009
of the Koltzov Institute of Developmental Biology of the RAS. The study of molecular
patterning of D. pumila colony was funded by RFBR, project number 20-04-00978a (to
S.K.)."
article_number: '9382'
article_processing_charge: No
article_type: original
author:
- first_name: Alexandra A.
full_name: Vetrova, Alexandra A.
last_name: Vetrova
- first_name: Daria M.
full_name: Kupaeva, Daria M.
last_name: Kupaeva
- first_name: Alena
full_name: Kizenko, Alena
id: a521c60b-0815-11ed-9b02-b8bd522477c8
last_name: Kizenko
- first_name: Tatiana S.
full_name: Lebedeva, Tatiana S.
last_name: Lebedeva
- first_name: Peter
full_name: Walentek, Peter
last_name: Walentek
- first_name: Nikoloz
full_name: Tsikolia, Nikoloz
last_name: Tsikolia
- first_name: Stanislav V.
full_name: Kremnyov, Stanislav V.
last_name: Kremnyov
citation:
ama: Vetrova AA, Kupaeva DM, Kizenko A, et al. The evolutionary history of Brachyury
genes in Hydrozoa involves duplications, divergence, and neofunctionalization.
Scientific Reports. 2023;13. doi:10.1038/s41598-023-35979-8
apa: Vetrova, A. A., Kupaeva, D. M., Kizenko, A., Lebedeva, T. S., Walentek, P.,
Tsikolia, N., & Kremnyov, S. V. (2023). The evolutionary history of Brachyury
genes in Hydrozoa involves duplications, divergence, and neofunctionalization.
Scientific Reports. Springer Nature. https://doi.org/10.1038/s41598-023-35979-8
chicago: Vetrova, Alexandra A., Daria M. Kupaeva, Alena Kizenko, Tatiana S. Lebedeva,
Peter Walentek, Nikoloz Tsikolia, and Stanislav V. Kremnyov. “The Evolutionary
History of Brachyury Genes in Hydrozoa Involves Duplications, Divergence, and
Neofunctionalization.” Scientific Reports. Springer Nature, 2023. https://doi.org/10.1038/s41598-023-35979-8.
ieee: A. A. Vetrova et al., “The evolutionary history of Brachyury genes
in Hydrozoa involves duplications, divergence, and neofunctionalization,” Scientific
Reports, vol. 13. Springer Nature, 2023.
ista: Vetrova AA, Kupaeva DM, Kizenko A, Lebedeva TS, Walentek P, Tsikolia N, Kremnyov
SV. 2023. The evolutionary history of Brachyury genes in Hydrozoa involves duplications,
divergence, and neofunctionalization. Scientific Reports. 13, 9382.
mla: Vetrova, Alexandra A., et al. “The Evolutionary History of Brachyury Genes
in Hydrozoa Involves Duplications, Divergence, and Neofunctionalization.” Scientific
Reports, vol. 13, 9382, Springer Nature, 2023, doi:10.1038/s41598-023-35979-8.
short: A.A. Vetrova, D.M. Kupaeva, A. Kizenko, T.S. Lebedeva, P. Walentek, N. Tsikolia,
S.V. Kremnyov, Scientific Reports 13 (2023).
date_created: 2023-06-25T22:00:46Z
date_published: 2023-06-09T00:00:00Z
date_updated: 2023-08-02T06:17:18Z
day: '09'
ddc:
- '570'
department:
- _id: GradSch
doi: 10.1038/s41598-023-35979-8
external_id:
isi:
- '001006690200045'
pmid:
- '37296138'
file:
- access_level: open_access
checksum: baddf6b2fa9adf88263d4a3b0998f0f2
content_type: application/pdf
creator: dernst
date_created: 2023-06-26T09:58:53Z
date_updated: 2023-06-26T09:58:53Z
file_id: '13170'
file_name: 2023_ScientificReports_Vetrova.pdf
file_size: 4844149
relation: main_file
success: 1
file_date_updated: 2023-06-26T09:58:53Z
has_accepted_license: '1'
intvolume: ' 13'
isi: 1
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
pmid: 1
publication: Scientific Reports
publication_identifier:
eissn:
- 2045-2322
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: The evolutionary history of Brachyury genes in Hydrozoa involves duplications,
divergence, and neofunctionalization
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 13
year: '2023'
...
---
_id: '12329'
abstract:
- lang: eng
text: In this article, we develop two independent and new approaches to model epidemic
spread in a network. Contrary to the most studied models, those developed here
allow for contacts with different probabilities of transmitting the disease (transmissibilities).
We then examine each of these models using some mean field type approximations.
The first model looks at the late-stage effects of an epidemic outbreak and allows
for the computation of the probability that a given vertex was infected. This
computation is based on a mean field approximation and only depends on the number
of contacts and their transmissibilities. This approach shares many similarities
with percolation models in networks. The second model we develop is a dynamic
model which we analyze using a mean field approximation which highly reduces the
dimensionality of the system. In particular, the original system which individually
analyses each vertex of the network is reduced to one with as many equations as
different transmissibilities. Perhaps the greatest contribution of this article
is the observation that, in both these models, the existence and size of an epidemic
outbreak are linked to the properties of a matrix which we call the R-matrix.
This is a generalization of the basic reproduction number which more precisely
characterizes the main routes of infection.
acknowledgement: Gonçalo Oliveira is supported by the NOMIS Foundation, Fundação Serrapilheira
1812-27395, by CNPq grants 428959/2018-0 and 307475/2018-2, and by FAPERJ through
the grant Jovem Cientista do Nosso Estado E-26/202.793/2019.
article_number: '468'
article_processing_charge: No
article_type: original
author:
- first_name: Arturo
full_name: Gómez, Arturo
last_name: Gómez
- first_name: Goncalo
full_name: Oliveira, Goncalo
id: 58abbde8-f455-11eb-a497-98c8fd71b905
last_name: Oliveira
citation:
ama: Gómez A, Oliveira G. New approaches to epidemic modeling on networks. Scientific
Reports. 2023;13. doi:10.1038/s41598-022-19827-9
apa: Gómez, A., & Oliveira, G. (2023). New approaches to epidemic modeling on
networks. Scientific Reports. Springer Nature. https://doi.org/10.1038/s41598-022-19827-9
chicago: Gómez, Arturo, and Goncalo Oliveira. “New Approaches to Epidemic Modeling
on Networks.” Scientific Reports. Springer Nature, 2023. https://doi.org/10.1038/s41598-022-19827-9.
ieee: A. Gómez and G. Oliveira, “New approaches to epidemic modeling on networks,”
Scientific Reports, vol. 13. Springer Nature, 2023.
ista: Gómez A, Oliveira G. 2023. New approaches to epidemic modeling on networks.
Scientific Reports. 13, 468.
mla: Gómez, Arturo, and Goncalo Oliveira. “New Approaches to Epidemic Modeling on
Networks.” Scientific Reports, vol. 13, 468, Springer Nature, 2023, doi:10.1038/s41598-022-19827-9.
short: A. Gómez, G. Oliveira, Scientific Reports 13 (2023).
date_created: 2023-01-22T23:00:55Z
date_published: 2023-01-10T00:00:00Z
date_updated: 2023-08-01T12:31:40Z
day: '10'
ddc:
- '510'
department:
- _id: TaHa
doi: 10.1038/s41598-022-19827-9
external_id:
isi:
- '001003345000051'
file:
- access_level: open_access
checksum: a8b83739f4a951e83e0b2a778f03b327
content_type: application/pdf
creator: dernst
date_created: 2023-01-23T07:53:23Z
date_updated: 2023-01-23T07:53:23Z
file_id: '12336'
file_name: 2023_ScientificReports_Gomez.pdf
file_size: 2167792
relation: main_file
success: 1
file_date_updated: 2023-01-23T07:53:23Z
has_accepted_license: '1'
intvolume: ' 13'
isi: 1
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
publication: Scientific Reports
publication_identifier:
eissn:
- 2045-2322
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: New approaches to epidemic modeling on networks
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 13
year: '2023'
...
---
_id: '10731'
abstract:
- lang: eng
text: Motivated by COVID-19, we develop and analyze a simple stochastic model for
the spread of disease in human population. We track how the number of infected
and critically ill people develops over time in order to estimate the demand that
is imposed on the hospital system. To keep this demand under control, we consider
a class of simple policies for slowing down and reopening society and we compare
their efficiency in mitigating the spread of the virus from several different
points of view. We find that in order to avoid overwhelming of the hospital system,
a policy must impose a harsh lockdown or it must react swiftly (or both). While
reacting swiftly is universally beneficial, being harsh pays off only when the
country is patient about reopening and when the neighboring countries coordinate
their mitigation efforts. Our work highlights the importance of acting decisively
when closing down and the importance of patience and coordination between neighboring
countries when reopening.
acknowledgement: 'K.C. acknowledges support from ERC Consolidator Grant No. (863818:
ForM-SMart). A.P. acknowledges support from FWF Grant No. J-4220. M.A.N. acknowledges
support from Office of Naval Research grant N00014-16-1-2914 and from the John Templeton
Foundation.'
article_number: '1526'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Jakub
full_name: Svoboda, Jakub
id: 130759D2-D7DD-11E9-87D2-DE0DE6697425
last_name: Svoboda
orcid: 0000-0002-1419-3267
- first_name: Josef
full_name: Tkadlec, Josef
last_name: Tkadlec
- first_name: Andreas
full_name: Pavlogiannis, Andreas
id: 49704004-F248-11E8-B48F-1D18A9856A87
last_name: Pavlogiannis
orcid: 0000-0002-8943-0722
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Martin A.
full_name: Nowak, Martin A.
last_name: Nowak
citation:
ama: Svoboda J, Tkadlec J, Pavlogiannis A, Chatterjee K, Nowak MA. Infection dynamics
of COVID-19 virus under lockdown and reopening. Scientific Reports. 2022;12(1).
doi:10.1038/s41598-022-05333-5
apa: Svoboda, J., Tkadlec, J., Pavlogiannis, A., Chatterjee, K., & Nowak, M.
A. (2022). Infection dynamics of COVID-19 virus under lockdown and reopening.
Scientific Reports. Springer Nature. https://doi.org/10.1038/s41598-022-05333-5
chicago: Svoboda, Jakub, Josef Tkadlec, Andreas Pavlogiannis, Krishnendu Chatterjee,
and Martin A. Nowak. “Infection Dynamics of COVID-19 Virus under Lockdown and
Reopening.” Scientific Reports. Springer Nature, 2022. https://doi.org/10.1038/s41598-022-05333-5.
ieee: J. Svoboda, J. Tkadlec, A. Pavlogiannis, K. Chatterjee, and M. A. Nowak, “Infection
dynamics of COVID-19 virus under lockdown and reopening,” Scientific Reports,
vol. 12, no. 1. Springer Nature, 2022.
ista: Svoboda J, Tkadlec J, Pavlogiannis A, Chatterjee K, Nowak MA. 2022. Infection
dynamics of COVID-19 virus under lockdown and reopening. Scientific Reports. 12(1),
1526.
mla: Svoboda, Jakub, et al. “Infection Dynamics of COVID-19 Virus under Lockdown
and Reopening.” Scientific Reports, vol. 12, no. 1, 1526, Springer Nature,
2022, doi:10.1038/s41598-022-05333-5.
short: J. Svoboda, J. Tkadlec, A. Pavlogiannis, K. Chatterjee, M.A. Nowak, Scientific
Reports 12 (2022).
date_created: 2022-02-06T23:01:30Z
date_published: 2022-01-27T00:00:00Z
date_updated: 2025-07-14T09:10:12Z
day: '27'
ddc:
- '570'
department:
- _id: KrCh
doi: 10.1038/s41598-022-05333-5
ec_funded: 1
external_id:
arxiv:
- '2012.15155'
isi:
- '000749198000039'
file:
- access_level: open_access
checksum: 247afd30c173390940f099ead35a28ed
content_type: application/pdf
creator: alisjak
date_created: 2022-02-07T14:57:59Z
date_updated: 2022-02-07T14:57:59Z
file_id: '10744'
file_name: 2022_ScientificReports_Svoboda.pdf
file_size: 2971922
relation: main_file
success: 1
file_date_updated: 2022-02-07T14:57:59Z
has_accepted_license: '1'
intvolume: ' 12'
isi: 1
issue: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
project:
- _id: 0599E47C-7A3F-11EA-A408-12923DDC885E
call_identifier: H2020
grant_number: '863818'
name: 'Formal Methods for Stochastic Models: Algorithms and Applications'
publication: Scientific Reports
publication_identifier:
eissn:
- 2045-2322
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Infection dynamics of COVID-19 virus under lockdown and reopening
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 12
year: '2022'
...
---
_id: '10069'
abstract:
- lang: eng
text: 'The extent to which women differ in the course of blood cell counts throughout
pregnancy, and the importance of these changes to pregnancy outcomes has not been
well defined. Here, we develop a series of statistical analyses of repeated measures
data to reveal the degree to which women differ in the course of pregnancy, predict
the changes that occur, and determine the importance of these changes for post-partum
hemorrhage (PPH) which is one of the leading causes of maternal mortality. We
present a prospective cohort of 4082 births recorded at the University Hospital,
Lausanne, Switzerland between 2009 and 2014 where full labour records could be
obtained, along with complete blood count data taken at hospital admission. We
find significant differences, at a [Formula: see text] level, among women in how
blood count values change through pregnancy for mean corpuscular hemoglobin, mean
corpuscular volume, mean platelet volume, platelet count and red cell distribution
width. We find evidence that almost all complete blood count values show trimester-specific
associations with PPH. For example, high platelet count (OR 1.20, 95% CI 1.01-1.53),
high mean platelet volume (OR 1.58, 95% CI 1.04-2.08), and high erythrocyte levels
(OR 1.36, 95% CI 1.01-1.57) in trimester 1 increased PPH, but high values in trimester
3 decreased PPH risk (OR 0.85, 0.79, 0.67 respectively). We show that differences
among women in the course of blood cell counts throughout pregnancy have an important
role in shaping pregnancy outcome and tracking blood count value changes through
pregnancy improves identification of women at increased risk of postpartum hemorrhage.
This study provides greater understanding of the complex changes in blood count
values that occur through pregnancy and provides indicators to guide the stratification
of patients into risk groups.'
acknowledgement: This project was funded by an SNSF Eccellenza Grant to MRR (PCEGP3-181181),
and by core funding from the Institute of Science and Technology Austria. We would
like to thank the participants of the study and all the midwives and doctors for
the computerized obstetrical data.
article_number: '19238'
article_processing_charge: Yes
article_type: original
author:
- first_name: Matthew Richard
full_name: Robinson, Matthew Richard
id: E5D42276-F5DA-11E9-8E24-6303E6697425
last_name: Robinson
orcid: 0000-0001-8982-8813
- first_name: Marion
full_name: Patxot, Marion
last_name: Patxot
- first_name: Miloš
full_name: Stojanov, Miloš
last_name: Stojanov
- first_name: Sabine
full_name: Blum, Sabine
last_name: Blum
- first_name: David
full_name: Baud, David
last_name: Baud
citation:
ama: Robinson MR, Patxot M, Stojanov M, Blum S, Baud D. Postpartum hemorrhage risk
is driven by changes in blood composition through pregnancy. Scientific Reports.
2021;11. doi:10.1038/s41598-021-98411-z
apa: Robinson, M. R., Patxot, M., Stojanov, M., Blum, S., & Baud, D. (2021).
Postpartum hemorrhage risk is driven by changes in blood composition through pregnancy.
Scientific Reports. Springer Nature. https://doi.org/10.1038/s41598-021-98411-z
chicago: Robinson, Matthew Richard, Marion Patxot, Miloš Stojanov, Sabine Blum,
and David Baud. “Postpartum Hemorrhage Risk Is Driven by Changes in Blood Composition
through Pregnancy.” Scientific Reports. Springer Nature, 2021. https://doi.org/10.1038/s41598-021-98411-z.
ieee: M. R. Robinson, M. Patxot, M. Stojanov, S. Blum, and D. Baud, “Postpartum
hemorrhage risk is driven by changes in blood composition through pregnancy,”
Scientific Reports, vol. 11. Springer Nature, 2021.
ista: Robinson MR, Patxot M, Stojanov M, Blum S, Baud D. 2021. Postpartum hemorrhage
risk is driven by changes in blood composition through pregnancy. Scientific Reports.
11, 19238.
mla: Robinson, Matthew Richard, et al. “Postpartum Hemorrhage Risk Is Driven by
Changes in Blood Composition through Pregnancy.” Scientific Reports, vol.
11, 19238, Springer Nature, 2021, doi:10.1038/s41598-021-98411-z.
short: M.R. Robinson, M. Patxot, M. Stojanov, S. Blum, D. Baud, Scientific Reports
11 (2021).
date_created: 2021-10-03T22:01:21Z
date_published: 2021-09-28T00:00:00Z
date_updated: 2023-08-14T07:05:15Z
day: '28'
ddc:
- '618'
department:
- _id: MaRo
doi: 10.1038/s41598-021-98411-z
external_id:
isi:
- '000701575500083'
pmid:
- '34584125'
file:
- access_level: open_access
checksum: f002ec22f609f58e1263b79e7f79601e
content_type: application/pdf
creator: cchlebak
date_created: 2021-10-05T14:56:48Z
date_updated: 2021-10-05T14:56:48Z
file_id: '10091'
file_name: 2021_ScientificReports_Robinson.pdf
file_size: 6970368
relation: main_file
success: 1
file_date_updated: 2021-10-05T14:56:48Z
has_accepted_license: '1'
intvolume: ' 11'
isi: 1
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
pmid: 1
publication: Scientific Reports
publication_identifier:
eissn:
- 2045-2322
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Postpartum hemorrhage risk is driven by changes in blood composition through
pregnancy
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 11
year: '2021'
...
---
_id: '9997'
abstract:
- lang: eng
text: Indirect reciprocity is a mechanism for the evolution of cooperation based
on social norms. This mechanism requires that individuals in a population observe
and judge each other’s behaviors. Individuals with a good reputation are more
likely to receive help from others. Previous work suggests that indirect reciprocity
is only effective when all relevant information is reliable and publicly available.
Otherwise, individuals may disagree on how to assess others, even if they all
apply the same social norm. Such disagreements can lead to a breakdown of cooperation.
Here we explore whether the predominantly studied ‘leading eight’ social norms
of indirect reciprocity can be made more robust by equipping them with an element
of generosity. To this end, we distinguish between two kinds of generosity. According
to assessment generosity, individuals occasionally assign a good reputation to
group members who would usually be regarded as bad. According to action generosity,
individuals occasionally cooperate with group members with whom they would usually
defect. Using individual-based simulations, we show that the two kinds of generosity
have a very different effect on the resulting reputation dynamics. Assessment
generosity tends to add to the overall noise and allows defectors to invade. In
contrast, a limited amount of action generosity can be beneficial in a few cases.
However, even when action generosity is beneficial, the respective simulations
do not result in full cooperation. Our results suggest that while generosity can
favor cooperation when individuals use the most simple strategies of reciprocity,
it is disadvantageous when individuals use more complex social norms.
acknowledgement: 'This work was supported by the European Research Council CoG 863818
(ForM-SMArt) (to K.C.) and the European Research Council Starting Grant 850529:
E-DIRECT (to C.H.). L.S. received additional partial support by the Austrian Science
Fund (FWF) under Grant Z211-N23 (Wittgenstein Award).'
article_number: '17443'
article_processing_charge: Yes
article_type: original
author:
- first_name: Laura
full_name: Schmid, Laura
id: 38B437DE-F248-11E8-B48F-1D18A9856A87
last_name: Schmid
orcid: 0000-0002-6978-7329
- first_name: Pouya
full_name: Shati, Pouya
last_name: Shati
- first_name: Christian
full_name: Hilbe, Christian
last_name: Hilbe
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
citation:
ama: Schmid L, Shati P, Hilbe C, Chatterjee K. The evolution of indirect reciprocity
under action and assessment generosity. Scientific Reports. 2021;11(1).
doi:10.1038/s41598-021-96932-1
apa: Schmid, L., Shati, P., Hilbe, C., & Chatterjee, K. (2021). The evolution
of indirect reciprocity under action and assessment generosity. Scientific
Reports. Springer Nature. https://doi.org/10.1038/s41598-021-96932-1
chicago: Schmid, Laura, Pouya Shati, Christian Hilbe, and Krishnendu Chatterjee.
“The Evolution of Indirect Reciprocity under Action and Assessment Generosity.”
Scientific Reports. Springer Nature, 2021. https://doi.org/10.1038/s41598-021-96932-1.
ieee: L. Schmid, P. Shati, C. Hilbe, and K. Chatterjee, “The evolution of indirect
reciprocity under action and assessment generosity,” Scientific Reports,
vol. 11, no. 1. Springer Nature, 2021.
ista: Schmid L, Shati P, Hilbe C, Chatterjee K. 2021. The evolution of indirect
reciprocity under action and assessment generosity. Scientific Reports. 11(1),
17443.
mla: Schmid, Laura, et al. “The Evolution of Indirect Reciprocity under Action and
Assessment Generosity.” Scientific Reports, vol. 11, no. 1, 17443, Springer
Nature, 2021, doi:10.1038/s41598-021-96932-1.
short: L. Schmid, P. Shati, C. Hilbe, K. Chatterjee, Scientific Reports 11 (2021).
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relation: dissertation_contains
status: public
status: public
title: The evolution of indirect reciprocity under action and assessment generosity
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name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
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...
---
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abstract:
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text: BAX, a member of the BCL2 gene family, controls the committed step of the
intrinsic apoptotic program. Mitochondrial fragmentation is a commonly observed
feature of apoptosis, which occurs through the process of mitochondrial fission.
BAX has consistently been associated with mitochondrial fission, yet how BAX participates
in the process of mitochondrial fragmentation during apoptosis remains to be tested.
Time-lapse imaging of BAX recruitment and mitochondrial fragmentation demonstrates
that rapid mitochondrial fragmentation during apoptosis occurs after the complete
recruitment of BAX to the mitochondrial outer membrane (MOM). The requirement
of a fully functioning BAX protein for the fission process was demonstrated further
in BAX/BAK-deficient HCT116 cells expressing a P168A mutant of BAX. The mutant
performed fusion to restore the mitochondrial network. but was not demonstrably
recruited to the MOM after apoptosis induction. Under these conditions, mitochondrial
fragmentation was blocked. Additionally, we show that loss of the fission protein,
dynamin-like protein 1 (DRP1), does not temporally affect the initiation time
or rate of BAX recruitment, but does reduce the final level of BAX recruited to
the MOM during the late phase of BAX recruitment. These correlative observations
suggest a model where late-stage BAX oligomers play a functional part of the mitochondrial
fragmentation machinery in apoptotic cells.
article_number: '16565'
article_processing_charge: No
article_type: original
author:
- first_name: Margaret E
full_name: Maes, Margaret E
id: 3838F452-F248-11E8-B48F-1D18A9856A87
last_name: Maes
orcid: 0000-0001-9642-1085
- first_name: J. A.
full_name: Grosser, J. A.
last_name: Grosser
- first_name: R. L.
full_name: Fehrman, R. L.
last_name: Fehrman
- first_name: C. L.
full_name: Schlamp, C. L.
last_name: Schlamp
- first_name: R. W.
full_name: Nickells, R. W.
last_name: Nickells
citation:
ama: Maes ME, Grosser JA, Fehrman RL, Schlamp CL, Nickells RW. Completion of BAX
recruitment correlates with mitochondrial fission during apoptosis. Scientific
Reports. 2019;9. doi:10.1038/s41598-019-53049-w
apa: Maes, M. E., Grosser, J. A., Fehrman, R. L., Schlamp, C. L., & Nickells,
R. W. (2019). Completion of BAX recruitment correlates with mitochondrial fission
during apoptosis. Scientific Reports. Springer Nature. https://doi.org/10.1038/s41598-019-53049-w
chicago: Maes, Margaret E, J. A. Grosser, R. L. Fehrman, C. L. Schlamp, and R. W.
Nickells. “Completion of BAX Recruitment Correlates with Mitochondrial Fission
during Apoptosis.” Scientific Reports. Springer Nature, 2019. https://doi.org/10.1038/s41598-019-53049-w.
ieee: M. E. Maes, J. A. Grosser, R. L. Fehrman, C. L. Schlamp, and R. W. Nickells,
“Completion of BAX recruitment correlates with mitochondrial fission during apoptosis,”
Scientific Reports, vol. 9. Springer Nature, 2019.
ista: Maes ME, Grosser JA, Fehrman RL, Schlamp CL, Nickells RW. 2019. Completion
of BAX recruitment correlates with mitochondrial fission during apoptosis. Scientific
Reports. 9, 16565.
mla: Maes, Margaret E., et al. “Completion of BAX Recruitment Correlates with Mitochondrial
Fission during Apoptosis.” Scientific Reports, vol. 9, 16565, Springer
Nature, 2019, doi:10.1038/s41598-019-53049-w.
short: M.E. Maes, J.A. Grosser, R.L. Fehrman, C.L. Schlamp, R.W. Nickells, Scientific
Reports 9 (2019).
date_created: 2019-11-25T07:45:17Z
date_published: 2019-11-12T00:00:00Z
date_updated: 2023-08-30T07:26:54Z
day: '12'
ddc:
- '570'
department:
- _id: SaSi
doi: 10.1038/s41598-019-53049-w
external_id:
isi:
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pmid:
- '31719602'
file:
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checksum: 9ab397ed9c1c454b34bffb8cc863d734
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creator: dernst
date_created: 2019-11-25T07:49:52Z
date_updated: 2020-07-14T12:47:49Z
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file_name: 2019_ScientificReports_Maes.pdf
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intvolume: ' 9'
isi: 1
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: Scientific Reports
publication_identifier:
eissn:
- 2045-2322
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Completion of BAX recruitment correlates with mitochondrial fission during
apoptosis
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 9
year: '2019'
...