---
_id: '9535'
abstract:
- lang: eng
  text: The most well-studied function of DNA methylation in eukaryotic cells is the
    transcriptional silencing of genes and transposons. More recent results showed
    that many eukaryotes methylate the bodies of genes as well and that this methylation
    correlates with transcriptional activity rather than repression. The purpose of
    gene body methylation remains mysterious, but is potentially related to the histone
    variant H2A.Z. Studies in plants and animals have shown that the genome-wide distributions
    of H2A.Z and DNA methylation are strikingly anticorrelated. Furthermore, we and
    other investigators have shown that this relationship is likely to be the result
    of an ancient but unknown mechanism by which DNA methylation prevents the incorporation
    of H2A.Z. Recently, we discovered strong correlations between the presence of
    H2A.Z within gene bodies, the degree to which a gene's expression varies across
    tissue types or environmental conditions, and transcriptional misregulation in
    an h2a.z mutant. We propose that one basal function of gene body methylation is
    the establishment of constitutive expression patterns within housekeeping genes
    by excluding H2A.Z from their bodies.
article_processing_charge: No
article_type: review
author:
- first_name: D.
  full_name: Coleman-Derr, D.
  last_name: Coleman-Derr
- first_name: Daniel
  full_name: Zilberman, Daniel
  id: 6973db13-dd5f-11ea-814e-b3e5455e9ed1
  last_name: Zilberman
  orcid: 0000-0002-0123-8649
citation:
  ama: Coleman-Derr D, Zilberman D. DNA methylation, H2A.Z, and the regulation of
    constitutive expression. <i>Cold Spring Harbor Symposia on Quantitative Biology</i>.
    2012;77:147-154. doi:<a href="https://doi.org/10.1101/sqb.2012.77.014944">10.1101/sqb.2012.77.014944</a>
  apa: Coleman-Derr, D., &#38; Zilberman, D. (2012). DNA methylation, H2A.Z, and the
    regulation of constitutive expression. <i>Cold Spring Harbor Symposia on Quantitative
    Biology</i>. Cold Spring Harbor Laboratory Press. <a href="https://doi.org/10.1101/sqb.2012.77.014944">https://doi.org/10.1101/sqb.2012.77.014944</a>
  chicago: Coleman-Derr, D., and Daniel Zilberman. “DNA Methylation, H2A.Z, and the
    Regulation of Constitutive Expression.” <i>Cold Spring Harbor Symposia on Quantitative
    Biology</i>. Cold Spring Harbor Laboratory Press, 2012. <a href="https://doi.org/10.1101/sqb.2012.77.014944">https://doi.org/10.1101/sqb.2012.77.014944</a>.
  ieee: D. Coleman-Derr and D. Zilberman, “DNA methylation, H2A.Z, and the regulation
    of constitutive expression,” <i>Cold Spring Harbor Symposia on Quantitative Biology</i>,
    vol. 77. Cold Spring Harbor Laboratory Press, pp. 147–154, 2012.
  ista: Coleman-Derr D, Zilberman D. 2012. DNA methylation, H2A.Z, and the regulation
    of constitutive expression. Cold Spring Harbor Symposia on Quantitative Biology.
    77, 147–154.
  mla: Coleman-Derr, D., and Daniel Zilberman. “DNA Methylation, H2A.Z, and the Regulation
    of Constitutive Expression.” <i>Cold Spring Harbor Symposia on Quantitative Biology</i>,
    vol. 77, Cold Spring Harbor Laboratory Press, 2012, pp. 147–54, doi:<a href="https://doi.org/10.1101/sqb.2012.77.014944">10.1101/sqb.2012.77.014944</a>.
  short: D. Coleman-Derr, D. Zilberman, Cold Spring Harbor Symposia on Quantitative
    Biology 77 (2012) 147–154.
date_created: 2021-06-08T13:01:23Z
date_published: 2012-12-18T00:00:00Z
date_updated: 2021-12-14T08:33:09Z
day: '18'
department:
- _id: DaZi
doi: 10.1101/sqb.2012.77.014944
extern: '1'
external_id:
  pmid:
  - '23250988'
intvolume: '        77'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1101/sqb.2012.77.014944
month: '12'
oa: 1
oa_version: Published Version
page: 147-154
pmid: 1
publication: Cold Spring Harbor Symposia on Quantitative Biology
publication_identifier:
  eissn:
  - 1943-4456
  issn:
  - 0091-7451
publication_status: published
publisher: Cold Spring Harbor Laboratory Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: DNA methylation, H2A.Z, and the regulation of constitutive expression
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 77
year: '2012'
...