---
_id: '8131'
abstract:
- lang: eng
  text: The possibility to generate construct valid animal models enabled the development
    and testing of therapeutic strategies targeting the core features of autism spectrum
    disorders (ASDs). At the same time, these studies highlighted the necessity of
    identifying sensitive developmental time windows for successful therapeutic interventions.
    Animal and human studies also uncovered the possibility to stratify the variety
    of ASDs in molecularly distinct subgroups, potentially facilitating effective
    treatment design. Here, we focus on the molecular pathways emerging as commonly
    affected by mutations in diverse ASD-risk genes, on their role during critical
    windows of brain development and the potential treatments targeting these biological
    processes.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Bernadette
  full_name: Basilico, Bernadette
  id: 36035796-5ACA-11E9-A75E-7AF2E5697425
  last_name: Basilico
  orcid: 0000-0003-1843-3173
- first_name: Jasmin
  full_name: Morandell, Jasmin
  id: 4739D480-F248-11E8-B48F-1D18A9856A87
  last_name: Morandell
- first_name: Gaia
  full_name: Novarino, Gaia
  id: 3E57A680-F248-11E8-B48F-1D18A9856A87
  last_name: Novarino
  orcid: 0000-0002-7673-7178
citation:
  ama: Basilico B, Morandell J, Novarino G. Molecular mechanisms for targeted ASD
    treatments. <i>Current Opinion in Genetics and Development</i>. 2020;65(12):126-137.
    doi:<a href="https://doi.org/10.1016/j.gde.2020.06.004">10.1016/j.gde.2020.06.004</a>
  apa: Basilico, B., Morandell, J., &#38; Novarino, G. (2020). Molecular mechanisms
    for targeted ASD treatments. <i>Current Opinion in Genetics and Development</i>.
    Elsevier. <a href="https://doi.org/10.1016/j.gde.2020.06.004">https://doi.org/10.1016/j.gde.2020.06.004</a>
  chicago: Basilico, Bernadette, Jasmin Morandell, and Gaia Novarino. “Molecular Mechanisms
    for Targeted ASD Treatments.” <i>Current Opinion in Genetics and Development</i>.
    Elsevier, 2020. <a href="https://doi.org/10.1016/j.gde.2020.06.004">https://doi.org/10.1016/j.gde.2020.06.004</a>.
  ieee: B. Basilico, J. Morandell, and G. Novarino, “Molecular mechanisms for targeted
    ASD treatments,” <i>Current Opinion in Genetics and Development</i>, vol. 65,
    no. 12. Elsevier, pp. 126–137, 2020.
  ista: Basilico B, Morandell J, Novarino G. 2020. Molecular mechanisms for targeted
    ASD treatments. Current Opinion in Genetics and Development. 65(12), 126–137.
  mla: Basilico, Bernadette, et al. “Molecular Mechanisms for Targeted ASD Treatments.”
    <i>Current Opinion in Genetics and Development</i>, vol. 65, no. 12, Elsevier,
    2020, pp. 126–37, doi:<a href="https://doi.org/10.1016/j.gde.2020.06.004">10.1016/j.gde.2020.06.004</a>.
  short: B. Basilico, J. Morandell, G. Novarino, Current Opinion in Genetics and Development
    65 (2020) 126–137.
date_created: 2020-07-19T22:00:58Z
date_published: 2020-12-01T00:00:00Z
date_updated: 2024-09-10T12:04:25Z
day: '01'
ddc:
- '570'
department:
- _id: GaNo
doi: 10.1016/j.gde.2020.06.004
ec_funded: 1
external_id:
  isi:
  - '000598918900019'
  pmid:
  - '32659636'
file:
- access_level: open_access
  content_type: application/pdf
  creator: dernst
  date_created: 2020-07-22T06:47:45Z
  date_updated: 2020-07-22T06:47:45Z
  file_id: '8146'
  file_name: 2020_CurrentOpGenetics_Basilico.pdf
  file_size: 1381545
  relation: main_file
  success: 1
file_date_updated: 2020-07-22T06:47:45Z
has_accepted_license: '1'
intvolume: '        65'
isi: 1
issue: '12'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: 126-137
pmid: 1
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '754411'
  name: ISTplus - Postdoctoral Fellowships
- _id: 2548AE96-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: W1232-B24
  name: Molecular Drug Targets
- _id: 05A0D778-7A3F-11EA-A408-12923DDC885E
  grant_number: F07807
  name: Neural stem cells in autism and epilepsy
publication: Current Opinion in Genetics and Development
publication_identifier:
  eissn:
  - '18790380'
  issn:
  - 0959437X
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
  record:
  - id: '8620'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Molecular mechanisms for targeted ASD treatments
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 65
year: '2020'
...