---
_id: '10705'
abstract:
- lang: eng
  text: Although rigidity and jamming transitions have been widely studied in physics
    and material science, their importance in a number of biological processes, including
    embryo development, tissue homeostasis, wound healing, and disease progression,
    has only begun to be recognized in the past few years. The hypothesis that biological
    systems can undergo rigidity/jamming transitions is attractive, as it would allow
    these systems to change their material properties rapidly and strongly. However,
    whether such transitions indeed occur in biological systems, how they are being
    regulated, and what their physiological relevance might be, is still being debated.
    Here, we review theoretical and experimental advances from the past few years,
    focusing on the regulation and role of potential tissue rigidity transitions in
    different biological processes.
acknowledgement: We thank present and former members of the Heisenberg and Hannezo
  groups, in particular Bernat Corominas-Murtra and Nicoletta Petridou, for helpful
  discussions, and Claudia Flandoli for the artwork. We apologize for not being able
  to cite a number of highly relevant studies, to stay within the maximum allowed
  number of citations.
article_processing_charge: No
article_type: original
author:
- first_name: Edouard B
  full_name: Hannezo, Edouard B
  id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
  last_name: Hannezo
  orcid: 0000-0001-6005-1561
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
citation:
  ama: Hannezo EB, Heisenberg C-PJ. Rigidity transitions in development and disease.
    <i>Trends in Cell Biology</i>. 2022;32(5):P433-444. doi:<a href="https://doi.org/10.1016/j.tcb.2021.12.006">10.1016/j.tcb.2021.12.006</a>
  apa: Hannezo, E. B., &#38; Heisenberg, C.-P. J. (2022). Rigidity transitions in
    development and disease. <i>Trends in Cell Biology</i>. Cell Press. <a href="https://doi.org/10.1016/j.tcb.2021.12.006">https://doi.org/10.1016/j.tcb.2021.12.006</a>
  chicago: Hannezo, Edouard B, and Carl-Philipp J Heisenberg. “Rigidity Transitions
    in Development and Disease.” <i>Trends in Cell Biology</i>. Cell Press, 2022.
    <a href="https://doi.org/10.1016/j.tcb.2021.12.006">https://doi.org/10.1016/j.tcb.2021.12.006</a>.
  ieee: E. B. Hannezo and C.-P. J. Heisenberg, “Rigidity transitions in development
    and disease,” <i>Trends in Cell Biology</i>, vol. 32, no. 5. Cell Press, pp. P433-444,
    2022.
  ista: Hannezo EB, Heisenberg C-PJ. 2022. Rigidity transitions in development and
    disease. Trends in Cell Biology. 32(5), P433-444.
  mla: Hannezo, Edouard B., and Carl-Philipp J. Heisenberg. “Rigidity Transitions
    in Development and Disease.” <i>Trends in Cell Biology</i>, vol. 32, no. 5, Cell
    Press, 2022, pp. P433-444, doi:<a href="https://doi.org/10.1016/j.tcb.2021.12.006">10.1016/j.tcb.2021.12.006</a>.
  short: E.B. Hannezo, C.-P.J. Heisenberg, Trends in Cell Biology 32 (2022) P433-444.
date_created: 2022-01-30T23:01:34Z
date_published: 2022-05-01T00:00:00Z
date_updated: 2023-08-02T14:03:53Z
day: '01'
department:
- _id: EdHa
- _id: CaHe
doi: 10.1016/j.tcb.2021.12.006
external_id:
  isi:
  - '000795773900009'
  pmid:
  - '35058104'
intvolume: '        32'
isi: 1
issue: '5'
language:
- iso: eng
month: '05'
oa_version: None
page: P433-444
pmid: 1
publication: Trends in Cell Biology
publication_identifier:
  eissn:
  - 1879-3088
  issn:
  - 0962-8924
publication_status: published
publisher: Cell Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Rigidity transitions in development and disease
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 32
year: '2022'
...