---
_id: '14080'
abstract:
- lang: eng
  text: Extracellular signal-regulated kinase (ERK) has been recognized as a critical
    regulator in various physiological and pathological processes. Extensive research
    has elucidated the signaling mechanisms governing ERK activation via biochemical
    regulations with upstream molecules, particularly receptor tyrosine kinases (RTKs).
    However, recent advances have highlighted the role of mechanical forces in activating
    the RTK–ERK signaling pathways, thereby opening new avenues of research into mechanochemical
    interplay in multicellular tissues. Here, we review the force-induced ERK activation
    in cells and propose possible mechanosensing mechanisms underlying the mechanoresponsive
    ERK activation. We conclude that mechanical forces are not merely passive factors
    shaping cells and tissues but also active regulators of cellular signaling pathways
    controlling collective cell behaviors.
acknowledgement: TH was supported by JSPS KAKENHI Grant (no. 21H05290) and the Ministry
  of Education under the Research Centres of Excellence programme through the Mechanobiology
  Institute at National University of Singapore and by Department of Physiology at
  National University of Singapore. NH was supported by JSPS KAKENHI Grant (no. 20K22653).
  KA was supported by JSPS KAKENHI Grants (no. 19H05798 and no. 22H02625). MM was
  supported by JSPS KAKENHI Grants (no. 19H00993 and no. 20H05898) and JST Moonshot
  R&D Grant JPMJPS2022. We appreciate Virgile Viasnoff and the lab members for their
  valuable comments on the manuscript. We apologize to authors whose work could not
  be highlighted due to space limitations.
article_number: '102217'
article_processing_charge: Yes (in subscription journal)
article_type: review
author:
- first_name: Tsuyoshi
  full_name: Hirashima, Tsuyoshi
  last_name: Hirashima
- first_name: Naoya
  full_name: Hino, Naoya
  id: 5299a9ce-7679-11eb-a7bc-d1e62b936307
  last_name: Hino
- first_name: Kazuhiro
  full_name: Aoki, Kazuhiro
  last_name: Aoki
- first_name: Michiyuki
  full_name: Matsuda, Michiyuki
  last_name: Matsuda
citation:
  ama: Hirashima T, Hino N, Aoki K, Matsuda M. Stretching the limits of extracellular
    signal-related kinase (ERK) signaling — Cell mechanosensing to ERK activation.
    <i>Current Opinion in Cell Biology</i>. 2023;84(10). doi:<a href="https://doi.org/10.1016/j.ceb.2023.102217">10.1016/j.ceb.2023.102217</a>
  apa: Hirashima, T., Hino, N., Aoki, K., &#38; Matsuda, M. (2023). Stretching the
    limits of extracellular signal-related kinase (ERK) signaling — Cell mechanosensing
    to ERK activation. <i>Current Opinion in Cell Biology</i>. Elsevier. <a href="https://doi.org/10.1016/j.ceb.2023.102217">https://doi.org/10.1016/j.ceb.2023.102217</a>
  chicago: Hirashima, Tsuyoshi, Naoya Hino, Kazuhiro Aoki, and Michiyuki Matsuda.
    “Stretching the Limits of Extracellular Signal-Related Kinase (ERK) Signaling
    — Cell Mechanosensing to ERK Activation.” <i>Current Opinion in Cell Biology</i>.
    Elsevier, 2023. <a href="https://doi.org/10.1016/j.ceb.2023.102217">https://doi.org/10.1016/j.ceb.2023.102217</a>.
  ieee: T. Hirashima, N. Hino, K. Aoki, and M. Matsuda, “Stretching the limits of
    extracellular signal-related kinase (ERK) signaling — Cell mechanosensing to ERK
    activation,” <i>Current Opinion in Cell Biology</i>, vol. 84, no. 10. Elsevier,
    2023.
  ista: Hirashima T, Hino N, Aoki K, Matsuda M. 2023. Stretching the limits of extracellular
    signal-related kinase (ERK) signaling — Cell mechanosensing to ERK activation.
    Current Opinion in Cell Biology. 84(10), 102217.
  mla: Hirashima, Tsuyoshi, et al. “Stretching the Limits of Extracellular Signal-Related
    Kinase (ERK) Signaling — Cell Mechanosensing to ERK Activation.” <i>Current Opinion
    in Cell Biology</i>, vol. 84, no. 10, 102217, Elsevier, 2023, doi:<a href="https://doi.org/10.1016/j.ceb.2023.102217">10.1016/j.ceb.2023.102217</a>.
  short: T. Hirashima, N. Hino, K. Aoki, M. Matsuda, Current Opinion in Cell Biology
    84 (2023).
date_created: 2023-08-20T22:01:12Z
date_published: 2023-10-01T00:00:00Z
date_updated: 2024-01-30T12:52:42Z
day: '01'
ddc:
- '570'
department:
- _id: CaHe
doi: 10.1016/j.ceb.2023.102217
external_id:
  isi:
  - '001054692200001'
  pmid:
  - '37574635'
file:
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  creator: dernst
  date_created: 2024-01-30T12:52:12Z
  date_updated: 2024-01-30T12:52:12Z
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file_date_updated: 2024-01-30T12:52:12Z
has_accepted_license: '1'
intvolume: '        84'
isi: 1
issue: '10'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
pmid: 1
publication: Current Opinion in Cell Biology
publication_identifier:
  eissn:
  - 1879-0410
  issn:
  - 0955-0674
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Stretching the limits of extracellular signal-related kinase (ERK) signaling
  — Cell mechanosensing to ERK activation
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 84
year: '2023'
...